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51.

Research article   Open Access Highly Accessed

Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions

Khaled K Abu-Amero, Ali Hellani, Ana M González, Jose M Larruga, Vicente M Cabrera, Peter A Underhill BMC Genetics 2009, 10:59 (22 September 2009)

Abstract | Full text | PDF | PubMed

52.

Research article   Open Access Highly Accessed

Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development

James F Fries, Eswar Krishnan Arthritis Res Ther 2004, 6:R250-R255 (18 March 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The 'uncertainty principle' states that randomised controlled trials are only ethical if true uncertainty exists about which treatment is likely to be superior. Is this principle being violated in industry-sponsored trials?

53.

Review   Open Access Highly Accessed

Mechanisms of stomatal development: an evolutionary view

Anne Vatén, Dominique C Bergmann EvoDevo 2012, 3:11 (12 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

54.

Research   Open Access Highly Accessed

Population-specificity of human DNA methylation

Hunter B Fraser, Lucia L Lam, Sarah M Neumann, Michael S Kobor Genome Biology 2012, 13:R8 (9 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Measurement of TSS-proximal DNA methylation in CEU and YRI genomes reveals significant population specificity

55.

Case report   Open Access Highly Accessed

Aerosolized amikacin for treatment of pulmonary Mycobacterium avium infections: an observational case series

Kala K Davis, Peter N Kao, Susan S Jacobs, Stephen J Ruoss BMC Pulmonary Medicine 2007, 7:2 (23 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

56.

Interview   Open Access Highly Accessed

An interview with Patrick O Brown on the origins and future of open access

Patrick O Brown BMC Biology 2013, 11:33 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.

57.

Study protocol   Open Access Highly Accessed

A school-based intervention to promote physical activity among adolescent girls: Rationale, design, and baseline data from the Girls in Sport group randomised controlled trial

Anthony D Okely, Wayne G Cotton, David R Lubans, Philip J Morgan, Lauren Puglisi, Judy Miller, Jan Wright, Marijka J Batterham, Louisa R Peralta, Janine Perry BMC Public Health 2011, 11:658 (19 August 2011)

Abstract | Full text | PDF | PubMed

58.

Editorial   Free Highly Accessed

Is breast cancer a part of Lynch syndrome?

James M Ford Breast Cancer Research 2012, 14:110 (22 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

59.

Research article   Open Access Highly Accessed

Identification and characterization of small non-coding RNAs from Chinese fir by high throughput sequencing

Li-Chuan Wan, Feng Wang, Xiangqian Guo, Shanfa Lu, Zongbo Qiu, Yuanyuan Zhao, Haiyan Zhang, Jinxing Lin BMC Plant Biology 2012, 12:146 (15 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

60.

Research article   Open Access Highly Accessed

Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis

Abigail McGuire, Brian Weiner, Sang Park, Ilan Wapinski, Sahadevan Raman, Gregory Dolganov, Matthew Peterson, Robert Riley, Jeremy Zucker, Thomas Abeel, Jared White, Peter Sisk, Christian Stolte, Mike Koehrsen, Robert T Yamamoto, Milena Iacobelli-Martinez, Matthew J Kidd, Andreia M Maer, Gary K Schoolnik, Aviv Regev, James Galagan BMC Genomics 2012, 13:120 (28 March 2012)

Abstract | Full text | PDF | PubMed

61.

Research article   Open Access Highly Accessed

Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis

Gurkirpal Singh, Olivia Wu, Peter Langhorne, Rajan Madhok Arthritis Research & Therapy 2006, 8:R153 (22 September 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

NSAIDs have been shown to be associated with an increased risk of acute myocardial infarctions, suggesting they should be used with caution in those with risk factors for cardiovascular disease.

62.

Open letter   Free Highly Accessed

The ethics of characterizing difference: guiding principles on using racial categories in human genetics

Sandra Lee, Joanna Mountain, Barbara Koenig, Russ Altman, Melissa Brown, Albert Camarillo, Luca Cavalli-Sforza, Mildred Cho, Jennifer Eberhardt, Marcus Feldman, Richard Ford, Henry Greely, Roy King, Hazel Markus, Debra Satz, Matthew Snipp, Claude Steele, Peter Underhill Genome Biology 2008, 9:404 (15 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

We are a multidisciplinary group of Stanford faculty who propose ten principles to guide the use of racial and ethnic categories when characterizing group differences in research into human genetic variation.

63.

Research article   Open Access Highly Accessed

Chronic kidney disease in gout in a managed care setting

Mahesh J Fuldeore, Aylin A Riedel, Victoria Zarotsky, Bhavik J Pandya, Omar Dabbous, Eswar Krishnan BMC Nephrology 2011, 12:36 (3 August 2011)

Abstract | Full text | PDF | PubMed

64.

Editorial   Open Access Highly Accessed

Changing computational research. The challenges ahead

Cameron Neylon, Jan Aerts, C Brown, Simon J Coles, Les Hatton, Daniel Lemire, K Millman, Peter Murray-Rust, Fernando Perez, Neil Saunders, Nigam Shah, Arfon Smith, Gaël Varoquaux, Egon Willighagen Source Code for Biology and Medicine 2012, 7:2 (28 May 2012)

Abstract | Full text | PDF | PubMed

65.

Research   Open Access Highly Accessed

Pathogenic landscapes: Interactions between land, people, disease vectors, and their animal hosts

Eric F Lambin, Annelise Tran, Sophie O Vanwambeke, Catherine Linard, Valérie Soti International Journal of Health Geographics 2010, 9:54 (27 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology

66.

Research   Open Access Highly Accessed

A DNA microarray survey of gene expression in normal human tissues

Radha Shyamsundar, Young H Kim, John P Higgins, Kelli Montgomery, Michelle Jorden, Anand Sethuraman, Matt van de Rijn, David Botstein, Patrick O Brown, Jonathan R Pollack Genome Biology 2005, 6:R22 (14 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A systematic survey of gene expression in 115 human tissue samples using cDNA microarrays provides a dataset that can be used as a baseline for comparison with expression in diseased tissue.

67.

Comment   Open Access Highly Accessed

Domesticating the beast

Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.

68.

Review   Open Access

Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones

Jie Hu, Zhonghua Zhang, Wen-Jun Shen, Salman Azhar Nutrition & Metabolism 2010, 7:47 (1 June 2010)

Abstract | Full text | PDF | PubMed

69.

Research article   Open Access Highly Accessed

Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes

Walter L Eckalbar, Elizabeth D Hutchins, Glenn J Markov, April N Allen, Jason J Corneveaux, Kerstin Lindblad-Toh, Federica Di Palma, Jessica Alföldi, Matthew J Huentelman, Kenro Kusumi BMC Genomics 2013, 14:49 (23 January 2013)

Abstract | Full text | PDF | PubMed

70.

Method   Open Access

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis

Simon E Alfred, Anuradha Surendra, Chris Le, Ken Lin, Alexander Mok, Iain M Wallace, Michael Proctor, Malene L Urbanus, Guri Giaever, Corey Nislow Genome Biology 2012, 13:R105 (18 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

An automated small molecule screening method for Chlamydomonas reinhardtii, and its application to identify bioactive compounds for agriculture, biofuels and therapeutics

71.

Research   Open Access

Use of insecticide-treated nets (ITNs) following a malaria education intervention in Piron, Mali: a control trial with systematic allocation of households

Michelle Rhee, Mahamadou Sissoko, Sharon Perry, Willi McFarland, Julie Parsonnet, Ogobara Doumbo Malaria Journal 2005, 4:35 (25 July 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Before the advent of long-lasting insecticidal nets, the need to re-impregnate bed nets regularly was a major obstacle for intervention programmes. This study from Mali shows that the education component of such programmes can substantially improve success rates.

72.

Research   Open Access Highly Accessed

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

Aaron M Newman, Natasha B Gallo, Lisa S Hancox, Norma J Miller, Carolyn M Radeke, Michelle A Maloney, James B Cooper, Gregory S Hageman, Don H Anderson, Lincoln V Johnson, Monte J Radeke Genome Medicine 2012, 4:16 (24 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Comparative transcriptome profiling of eye specimens, integrated with functionally enriched protein network analysis reveals candidate drug targets for treating age-related macular degeneration.

73.

Research article   Open Access Highly Accessed

The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

Betty Y Chang, Min Huang, Michelle Francesco, Jun Chen, Jeremy Sokolove, Padmaja Magadala, William H Robinson, Joseph J Buggy Arthritis Research & Therapy 2011, 13:R115 (13 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

74.

Methodology article   Open Access Highly Accessed

STOP using just GO: a multi-ontology hypothesis generation tool for high throughput experimentation

Tobias Wittkop, Emily TerAvest, Uday S Evani, K Fleisch, Ari E Berman, Corey Powell, Nigam H Shah, Sean D Mooney BMC Bioinformatics 2013, 14:53 (14 February 2013)

Abstract | Full text | PDF | PubMed

75.

Review   Free Highly Accessed

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

Alvaro Rada-Iglesias, Joanna Wysocka Genome Medicine 2011, 3:36 (7 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Wysocka and Rada-Iglesias review advances in epigenomic profiling of human pluripotent stem cells, highlighting the roles of regulatory elements and the implications for disease.

76.

Research   Open Access Highly Accessed

A survey of enabling technologies in synthetic biology

Linda J Kahl, Drew Endy Journal of Biological Engineering 2013, 7:13 (10 May 2013)

Abstract | Full text | PDF | PubMed

77.

Research article   Open Access Highly Accessed

Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance

Anne S Quante, Alice S Whittemore, Tom Shriver, Konstantin Strauch, Mary B Terry Breast Cancer Research 2012, 14:R144 (5 November 2012)

Abstract | Full text | PDF | PubMed

78.

Methodology article   Open Access Highly Accessed

Digital PCR provides sensitive and absolute calibration for high throughput sequencing

Richard A White, Paul C Blainey, H Christina Fan, Stephen R Quake BMC Genomics 2009, 10:116 (19 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

79.

Research   Open Access

Multi-Country analysis of palm oil consumption and cardiovascular disease mortality for countries at different stages of economic development: 1980-1997

Brian K Chen, Benjamin Seligman, John W Farquhar, Jeremy D Goldhaber-Fiebert Globalization and Health 2011, 7:45 (16 December 2011)

Abstract | Full text | PDF | PubMed

80.

Research   Open Access Highly Accessed

Measurement of a model of implementation for health care: toward a testable theory

Joan M Cook, Casey O’Donnell, Stephanie Dinnen, James C Coyne, Josef I Ruzek, Paula P Schnurr Implementation Science 2012, 7:59 (3 July 2012)

Abstract | Full text | PDF | PubMed

81.

Proceedings   Open Access Highly Accessed

The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside

Joanne S Luciano, Bosse Andersson, Colin Batchelor, Olivier Bodenreider, Tim Clark, Christine K Denney, Christopher Domarew, Thomas Gambet, Lee Harland, Anja Jentzsch, Vipul Kashyap, Peter Kos, Julia Kozlovsky, Timothy Lebo, Scott M Marshall, James P McCusker, Deborah L McGuinness, Chimezie Ogbuji, Elgar Pichler, Robert L Powers, Eric Prud’hommeaux, Matthias Samwald, Lynn Schriml, Peter J Tonellato, Patricia L Whetzel, Jun Zhao, Susie Stephens, Michel Dumontier Journal of Biomedical Semantics 2011, 2(Suppl 2):S1 (17 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

82.

Research   Open Access

Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs

Michelle Kudron, Wei Niu, Zhi Lu, Guilin Wang, Mark Gerstein, Michael Snyder, Valerie Reinke Genome Biology 2013, 14:R5 (23 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The tissue specificity of Rb/E2F binding profiles enables the promotion of both somatic and germline transcriptional programs

83.

Letter   Free Highly Accessed

Potential for overuse of corticosteroids and vasopressin in septic shock

Joe L Hsu, Vincent Liu, Andrew J Patterson, Greg S Martin, Mark R Nicolls, James A Russell Critical Care 2012, 16:447 (6 September 2012)

Abstract | Full text | PDF | PubMed

84.

Research article   Open Access Highly Accessed

Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer

Rachel L Dusek, Jamie L Bascom, Hannes Vogel, Sylvain Baron, Alexander D Borowsky, Mina J Bissell, Laura D Attardi Breast Cancer Research 2012, 14:R65 (20 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The protein Perp, associated with desmosomes - the glue that sticks cells together - is involved in suppressing breast cancer and provides a potential new target for future treatment.

85.

Commentary   Open Access

OMERACT: An international initiative to improve outcome measurement in rheumatology

Peter Tugwell, Maarten Boers, Peter Brooks, Lee Simon, Vibeke Strand, Leanne Idzerda Trials 2007, 8:38 (26 November 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

86.

Research article   Open Access Highly Accessed

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

Chih Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh, Paul J Utz Arthritis Research & Therapy 2012, 14:R25 (2 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

87.

Correspondence   Open Access Highly Accessed

Translational bioinformatics in the cloud: an affordable alternative

Joel T Dudley, Yannick Pouliot, Rong Chen, Alexander A Morgan, Atul J Butte Genome Medicine 2010, 2:51 (6 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Cloud-based analysis offers a valid alternative both in terms of performance and cost to local computational clusters for the integration and analysis of large-scale genomic datasets relevant for translational research.

88.

Review   Open Access

Mental health issues in unaccompanied refugee minors

Julia Huemer, Niranjan S Karnik, Sabine Voelkl-Kernstock, Elisabeth Granditsch, Kanita Dervic, Max H Friedrich, Hans Steiner Child and Adolescent Psychiatry and Mental Health 2009, 3:13 (2 April 2009)

Abstract | Full text | PDF | PubMed

89.

Research article   Open Access Highly Accessed

Development of an EGFRvIII specific recombinant antibody

Puja Gupta, Shuang-Yin Han, Marina Holgado-Madruga, Siddhartha S Mitra, Gordon Li, Ryan T Nitta, Albert J Wong BMC Biotechnology 2010, 10:72 (7 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

90.

Method   Open Access Highly Accessed

Modeling non-uniformity in short-read rates in RNA-Seq data

Jun Li, Hui Jiang, Wing Wong Genome Biology 2010, 11:R50 (11 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Methods for modeling read counts from short read RNA-seq data.

91.

Research   Open Access Highly Accessed

Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with Hereditary Ataxia

Wan-Zhang Yang, Yun Zhang, Fang Wu, Min Zhang, SC Cho, Chun-Zhen Li, Shao-Hui Li, Guo-Jian Shu, You-Xiang Sheng, Ning Zhao, Ying Tang, Shu Jiang, Shan Jiang, Matthew Gandjian, Thomas E Ichim, Xiang Hu Journal of Translational Medicine 2011, 9:65 (16 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

92.

Research   Open Access Highly Accessed

Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers

Robert C Spitale, Michelle Y Cheng, Kimberly A Chun, Emily S Gorell, Claudia A Munoz, Dale G Kern, Steve M Wood, Helen E Knaggs, Jacob Wulff, Kirk D Beebe, Anne Lynn S Chang Genome Medicine 2012, 4:14 (23 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A study of the effects of antioxidant dietary supplementation on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.

93.

Research   Open Access

Mediation of Drosophila autosomal dosage effects and compensation by network interactions

John H Malone, Dong-Yeon Cho, Nicolas R Mattiuzzo, Carlo G Artieri, Lichun Jiang, Ryan K Dale, Harold E Smith, Jennifer McDaniel, Sarah Munro, Marc Salit, Justen Andrews, Teresa M Przytycka, Brian Oliver Genome Biology 2012, 13:R28 (24 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A comprehensive RNA-seq analysis of autosomal dosage effects and compensation in 21 autosomal deficiency Drosophila lines

94.

Research   Open Access Highly Accessed

Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder

Christian E Waugh, J Hamilton, Michael C Chen, Jutta Joormann, Ian H Gotlib Biology of Mood & Anxiety Disorders 2012, 2:11 (22 June 2012)

Abstract | Full text | PDF | PubMed

95.

Research article   Open Access Highly Accessed

Cell-type specific gene expression profiles of leukocytes in human peripheral blood

Chana Palmer, Maximilian Diehn, Ash A Alizadeh, Patrick O Brown BMC Genomics 2006, 7:115 (16 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

96.

Comment   Open Access

Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms

Stephen J Benkovic, Julie Theriot, Dagmar Ringe BMC Biology 2013, 11:8 (31 January 2013)

Abstract | Full text | PDF | PubMed

97.

Focus   Open Access

What makes man human: thirty-ninth James Arthur lecture on the evolution of the human brain, 1970

Karl H Pribram Journal of Biomedical Discovery and Collaboration 2006, 1:13 (29 November 2006)

Abstract | Full text | PDF | PubMed

98.

Research   Open Access

Addressing substance abuse and violence in substance use disorder treatment and batterer intervention programs

Christine Timko, Helen Valenstein, Patricia Y Lin, Rudolf H Moos, Gregory L Stuart, Ruth C Cronkite Substance Abuse Treatment, Prevention, and Policy 2012, 7:37 (7 September 2012)

Abstract | Full text | PDF | PubMed

99.

Research article   Open Access Highly Accessed

Evolutionarily consistent families in SCOP: sequence, structure and function

Ralph B Pethica, Michael Levitt, Julian Gough BMC Structural Biology 2012, 12:27 (18 October 2012)

Abstract | Full text | PDF | PubMed

100.

Review   Open Access

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

Reza Ehsanian, Carter Van Waes, Stephan M Feller Cell Communication and Signaling 2011, 9:13 (15 May 2011)

Abstract | Full text | PDF | PubMed

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