51.
Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions
Khaled
K
Abu-Amero,
Ali
Hellani,
Ana
M
González,
Jose
M
Larruga,
Vicente
M
Cabrera,
Peter
A
Underhill
BMC Genetics 2009, 10 :59 (22 September 2009)
Abstract | Full text | PDF | PubMed
52.
Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development
James
F
Fries,
Eswar
Krishnan
Arthritis Res Ther 2004, 6 :R250-R255 (18 March 2004)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
The 'uncertainty principle' states that randomised controlled trials are only ethical if true uncertainty exists about which treatment is likely to be superior. Is this principle being violated in industry-sponsored trials?
53.
Mechanisms of stomatal development: an evolutionary view
Anne
Vatén,
Dominique
C
Bergmann
EvoDevo 2012, 3 :11 (12 June 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
54.
Population-specificity of human DNA methylation
Hunter
B
Fraser,
Lucia
L
Lam,
Sarah
M
Neumann,
Michael
S
Kobor
Genome Biology 2012, 13 :R8 (9 February 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Measurement of TSS-proximal DNA methylation in CEU and YRI genomes reveals significant population specificity
55.
Aerosolized amikacin for treatment of pulmonary Mycobacterium avium infections: an observational case series
Kala
K
Davis,
Peter
N
Kao,
Susan
S
Jacobs,
Stephen
J
Ruoss
BMC Pulmonary Medicine 2007, 7 :2 (23 February 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
56.
An interview with Patrick O Brown on the origins and future of open access
Patrick
O
Brown
BMC Biology 2013, 11 :33 (15 April 2013)
Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.
57.
A school-based intervention to promote physical activity among adolescent girls: Rationale, design, and baseline data from the Girls in Sport group randomised controlled trial
Anthony
D
Okely,
Wayne
G
Cotton,
David
R
Lubans,
Philip
J
Morgan,
Lauren
Puglisi,
Judy
Miller,
Jan
Wright,
Marijka
J
Batterham,
Louisa
R
Peralta,
Janine
Perry
BMC Public Health 2011, 11 :658 (19 August 2011)
Abstract | Full text | PDF | PubMed
58.
Is breast cancer a part of Lynch syndrome?
James
M
Ford
Breast Cancer Research 2012, 14 :110 (22 August 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
59.
Identification and characterization of small non-coding RNAs from Chinese fir by high throughput sequencing
Li-Chuan
Wan,
Feng
Wang,
Xiangqian
Guo,
Shanfa
Lu,
Zongbo
Qiu,
Yuanyuan
Zhao,
Haiyan
Zhang,
Jinxing
Lin
BMC Plant Biology 2012, 12 :146 (15 August 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
60.
Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis
Abigail
McGuire,
Brian
Weiner,
Sang
Park,
Ilan
Wapinski,
Sahadevan
Raman,
Gregory
Dolganov,
Matthew
Peterson,
Robert
Riley,
Jeremy
Zucker,
Thomas
Abeel,
Jared
White,
Peter
Sisk,
Christian
Stolte,
Mike
Koehrsen,
Robert
T
Yamamoto,
Milena
Iacobelli-Martinez,
Matthew
J
Kidd,
Andreia
M
Maer,
Gary
K
Schoolnik,
Aviv
Regev,
James
Galagan
BMC Genomics 2012, 13 :120 (28 March 2012)
Abstract | Full text | PDF | PubMed
61.
Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis
Gurkirpal
Singh,
Olivia
Wu,
Peter
Langhorne,
Rajan
Madhok
Arthritis Research & Therapy 2006, 8 :R153 (22 September 2006)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
NSAIDs have been shown to be associated with an increased risk of acute myocardial infarctions, suggesting they should be used with caution in those with risk factors for cardiovascular disease.
62.
The ethics of characterizing difference: guiding principles on using racial categories in human genetics
Sandra
Lee,
Joanna
Mountain,
Barbara
Koenig,
Russ
Altman,
Melissa
Brown,
Albert
Camarillo,
Luca
Cavalli-Sforza,
Mildred
Cho,
Jennifer
Eberhardt,
Marcus
Feldman,
Richard
Ford,
Henry
Greely,
Roy
King,
Hazel
Markus,
Debra
Satz,
Matthew
Snipp,
Claude
Steele,
Peter
Underhill
Genome Biology 2008, 9 :404 (15 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central |
|
Editor’s summary
We are a multidisciplinary group of Stanford faculty who propose ten principles to guide the use of racial and ethnic categories when characterizing group differences in research into human genetic variation.
63.
Chronic kidney disease in gout in a managed care setting
Mahesh
J
Fuldeore,
Aylin
A
Riedel,
Victoria
Zarotsky,
Bhavik
J
Pandya,
Omar
Dabbous,
Eswar
Krishnan
BMC Nephrology 2011, 12 :36 (3 August 2011)
Abstract | Full text | PDF | PubMed
64.
Changing computational research. The challenges ahead
Cameron
Neylon,
Jan
Aerts,
C
Brown,
Simon
J
Coles,
Les
Hatton,
Daniel
Lemire,
K
Millman,
Peter
Murray-Rust,
Fernando
Perez,
Neil
Saunders,
Nigam
Shah,
Arfon
Smith,
Gaël
Varoquaux,
Egon
Willighagen
Source Code for Biology and Medicine 2012, 7 :2 (28 May 2012)
Abstract | Full text | PDF | PubMed
65.
Pathogenic landscapes: Interactions between land, people, disease vectors, and their animal hosts
Eric
F
Lambin,
Annelise
Tran,
Sophie
O
Vanwambeke,
Catherine
Linard,
Valérie
Soti
International Journal of Health Geographics 2010, 9 :54 (27 October 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology
66.
A DNA microarray survey of gene expression in normal human tissues
Radha
Shyamsundar,
Young
H
Kim,
John
P
Higgins,
Kelli
Montgomery,
Michelle
Jorden,
Anand
Sethuraman,
Matt
van de Rijn,
David
Botstein,
Patrick
O
Brown,
Jonathan
R
Pollack
Genome Biology 2005, 6 :R22 (14 February 2005)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
A systematic survey of gene expression in 115 human tissue samples using cDNA microarrays provides a dataset that can be used as a baseline for comparison with expression in diseased tissue.
67.
Domesticating the beast
Virginia
Walbot
BMC Biology 2013, 11 :35 (15 April 2013)
Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts ?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.
68.
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Jie
Hu,
Zhonghua
Zhang,
Wen-Jun
Shen,
Salman
Azhar
Nutrition & Metabolism 2010, 7 :47 (1 June 2010)
Abstract | Full text | PDF | PubMed
69.
Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes
Walter
L
Eckalbar,
Elizabeth
D
Hutchins,
Glenn
J
Markov,
April
N
Allen,
Jason
J
Corneveaux,
Kerstin
Lindblad-Toh,
Federica
Di Palma,
Jessica
Alföldi,
Matthew
J
Huentelman,
Kenro
Kusumi
BMC Genomics 2013, 14 :49 (23 January 2013)
Abstract | Full text | PDF | PubMed
70.
A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis
Simon
E
Alfred,
Anuradha
Surendra,
Chris
Le,
Ken
Lin,
Alexander
Mok,
Iain
M
Wallace,
Michael
Proctor,
Malene
L
Urbanus,
Guri
Giaever,
Corey
Nislow
Genome Biology 2012, 13 :R105 (18 November 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
An automated small molecule screening method for Chlamydomonas reinhardtii, and its application to identify bioactive compounds for agriculture, biofuels and therapeutics
71.
Use of insecticide-treated nets (ITNs) following a malaria education intervention in Piron, Mali: a control trial with systematic allocation of households
Michelle
Rhee,
Mahamadou
Sissoko,
Sharon
Perry,
Willi
McFarland,
Julie
Parsonnet,
Ogobara
Doumbo
Malaria Journal 2005, 4 :35 (25 July 2005)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Before the advent of long-lasting insecticidal nets, the need to re-impregnate bed nets regularly was a major obstacle for intervention programmes. This study from Mali shows that the education component of such programmes can substantially improve success rates.
72.
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
Aaron
M
Newman,
Natasha
B
Gallo,
Lisa
S
Hancox,
Norma
J
Miller,
Carolyn
M
Radeke,
Michelle
A
Maloney,
James
B
Cooper,
Gregory
S
Hageman,
Don
H
Anderson,
Lincoln
V
Johnson,
Monte
J
Radeke
Genome Medicine 2012, 4 :16 (24 February 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Comparative transcriptome profiling of eye specimens, integrated with functionally enriched protein network analysis reveals candidate drug targets for treating age-related macular degeneration.
73.
The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells
Betty
Y
Chang,
Min
Huang,
Michelle
Francesco,
Jun
Chen,
Jeremy
Sokolove,
Padmaja
Magadala,
William
H
Robinson,
Joseph
J
Buggy
Arthritis Research & Therapy 2011, 13 :R115 (13 July 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
74.
STOP using just GO: a multi-ontology hypothesis generation tool for high throughput experimentation
Tobias
Wittkop,
Emily
TerAvest,
Uday
S
Evani,
K
Fleisch,
Ari
E
Berman,
Corey
Powell,
Nigam
H
Shah,
Sean
D
Mooney
BMC Bioinformatics 2013, 14 :53 (14 February 2013)
Abstract | Full text | PDF | PubMed
75.
Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease
Alvaro
Rada-Iglesias,
Joanna
Wysocka
Genome Medicine 2011, 3 :36 (7 June 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Wysocka and Rada-Iglesias review advances in epigenomic profiling of human pluripotent stem cells, highlighting the roles of regulatory elements and the implications for disease.
76.
A survey of enabling technologies in synthetic biology
Linda
J
Kahl,
Drew
Endy
Journal of Biological Engineering 2013, 7 :13 (10 May 2013)
Abstract | Full text | PDF | PubMed
77.
Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance
Anne
S
Quante,
Alice
S
Whittemore,
Tom
Shriver,
Konstantin
Strauch,
Mary
B
Terry
Breast Cancer Research 2012, 14 :R144 (5 November 2012)
Abstract | Full text | PDF | PubMed
78.
Digital PCR provides sensitive and absolute calibration for high throughput sequencing
Richard
A
White,
Paul
C
Blainey,
H Christina
Fan,
Stephen
R
Quake
BMC Genomics 2009, 10 :116 (19 March 2009)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
79.
Multi-Country analysis of palm oil consumption and cardiovascular disease mortality for countries at different stages of economic development: 1980-1997
Brian
K
Chen,
Benjamin
Seligman,
John
W
Farquhar,
Jeremy
D
Goldhaber-Fiebert
Globalization and Health 2011, 7 :45 (16 December 2011)
Abstract | Full text | PDF | PubMed
80.
Measurement of a model of implementation for health care: toward a testable theory
Joan
M
Cook,
Casey
O’Donnell,
Stephanie
Dinnen,
James
C
Coyne,
Josef
I
Ruzek,
Paula
P
Schnurr
Implementation Science 2012, 7 :59 (3 July 2012)
Abstract | Full text | PDF | PubMed
81.
The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside
Joanne
S
Luciano,
Bosse
Andersson,
Colin
Batchelor,
Olivier
Bodenreider,
Tim
Clark,
Christine
K
Denney,
Christopher
Domarew,
Thomas
Gambet,
Lee
Harland,
Anja
Jentzsch,
Vipul
Kashyap,
Peter
Kos,
Julia
Kozlovsky,
Timothy
Lebo,
Scott
M
Marshall,
James
P
McCusker,
Deborah
L
McGuinness,
Chimezie
Ogbuji,
Elgar
Pichler,
Robert
L
Powers,
Eric
Prud’hommeaux,
Matthias
Samwald,
Lynn
Schriml,
Peter
J
Tonellato,
Patricia
L
Whetzel,
Jun
Zhao,
Susie
Stephens,
Michel
Dumontier
Journal of Biomedical Semantics 2011, 2 (Suppl 2):S1 (17 May 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
82.
Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs
Michelle
Kudron,
Wei
Niu,
Zhi
Lu,
Guilin
Wang,
Mark
Gerstein,
Michael
Snyder,
Valerie
Reinke
Genome Biology 2013, 14 :R5 (23 January 2013)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
The tissue specificity of Rb/E2F binding profiles enables the promotion of both somatic and germline transcriptional programs
83.
Potential for overuse of corticosteroids and vasopressin in septic shock
Joe
L
Hsu,
Vincent
Liu,
Andrew
J
Patterson,
Greg
S
Martin,
Mark
R
Nicolls,
James
A
Russell
Critical Care 2012, 16 :447 (6 September 2012)
Abstract | Full text | PDF | PubMed
84.
Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer
Rachel
L
Dusek,
Jamie
L
Bascom,
Hannes
Vogel,
Sylvain
Baron,
Alexander
D
Borowsky,
Mina
J
Bissell,
Laura
D
Attardi
Breast Cancer Research 2012, 14 :R65 (20 April 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
The protein Perp, associated with desmosomes - the glue that sticks cells together - is involved in suppressing breast cancer and provides a potential new target for future treatment.
85.
OMERACT: An international initiative to improve outcome measurement in rheumatology
Peter
Tugwell,
Maarten
Boers,
Peter
Brooks,
Lee
Simon,
Vibeke
Strand,
Leanne
Idzerda
Trials 2007, 8 :38 (26 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
86.
Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies
Chih
Liu,
Stephanie
Tangsombatvisit,
Jacob
M
Rosenberg,
Gil
Mandelbaum,
Emily
C
Gillespie,
Or
P
Gozani,
Ash
A
Alizadeh,
Paul
J
Utz
Arthritis Research & Therapy 2012, 14 :R25 (2 February 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
87.
Translational bioinformatics in the cloud: an affordable alternative
Joel
T
Dudley,
Yannick
Pouliot,
Rong
Chen,
Alexander
A
Morgan,
Atul
J
Butte
Genome Medicine 2010, 2 :51 (6 August 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central |
|
Editor’s summary
Cloud-based analysis offers a valid alternative both in terms of performance and cost to local computational clusters for the integration and analysis of large-scale genomic datasets relevant for translational research.
88.
Mental health issues in unaccompanied refugee minors
Julia
Huemer,
Niranjan
S
Karnik,
Sabine
Voelkl-Kernstock,
Elisabeth
Granditsch,
Kanita
Dervic,
Max
H
Friedrich,
Hans
Steiner
Child and Adolescent Psychiatry and Mental Health 2009, 3 :13 (2 April 2009)
Abstract | Full text | PDF | PubMed
89.
Development of an EGFRvIII specific recombinant antibody
Puja
Gupta,
Shuang-Yin
Han,
Marina
Holgado-Madruga,
Siddhartha
S
Mitra,
Gordon
Li,
Ryan
T
Nitta,
Albert
J
Wong
BMC Biotechnology 2010, 10 :72 (7 October 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
90.
Modeling non-uniformity in short-read rates in RNA-Seq data
Jun
Li,
Hui
Jiang,
Wing
Wong
Genome Biology 2010, 11 :R50 (11 May 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Methods for modeling read counts from short read RNA-seq data.
91.
Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with Hereditary Ataxia
Wan-Zhang
Yang,
Yun
Zhang,
Fang
Wu,
Min
Zhang,
SC
Cho,
Chun-Zhen
Li,
Shao-Hui
Li,
Guo-Jian
Shu,
You-Xiang
Sheng,
Ning
Zhao,
Ying
Tang,
Shu
Jiang,
Shan
Jiang,
Matthew
Gandjian,
Thomas
E
Ichim,
Xiang
Hu
Journal of Translational Medicine 2011, 9 :65 (16 May 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
92.
Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers
Robert
C
Spitale,
Michelle
Y
Cheng,
Kimberly
A
Chun,
Emily
S
Gorell,
Claudia
A
Munoz,
Dale
G
Kern,
Steve
M
Wood,
Helen
E
Knaggs,
Jacob
Wulff,
Kirk
D
Beebe,
Anne Lynn
S
Chang
Genome Medicine 2012, 4 :14 (23 February 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
A study of the effects of antioxidant dietary supplementation
on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.
93.
Mediation of Drosophila autosomal dosage effects and compensation by network interactions
John
H
Malone,
Dong-Yeon
Cho,
Nicolas
R
Mattiuzzo,
Carlo
G
Artieri,
Lichun
Jiang,
Ryan
K
Dale,
Harold
E
Smith,
Jennifer
McDaniel,
Sarah
Munro,
Marc
Salit,
Justen
Andrews,
Teresa
M
Przytycka,
Brian
Oliver
Genome Biology 2012, 13 :R28 (24 April 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
A comprehensive RNA-seq analysis of autosomal dosage effects and compensation in 21 autosomal deficiency Drosophila lines
94.
Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder
Christian
E
Waugh,
J
Hamilton,
Michael
C
Chen,
Jutta
Joormann,
Ian
H
Gotlib
Biology of Mood & Anxiety Disorders 2012, 2 :11 (22 June 2012)
Abstract | Full text | PDF | PubMed
95.
Cell-type specific gene expression profiles of leukocytes in human peripheral blood
Chana
Palmer,
Maximilian
Diehn,
Ash
A
Alizadeh,
Patrick
O
Brown
BMC Genomics 2006, 7 :115 (16 May 2006)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
96.
Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms
Stephen
J
Benkovic,
Julie
Theriot,
Dagmar
Ringe
BMC Biology 2013, 11 :8 (31 January 2013)
Abstract | Full text | PDF | PubMed
97.
What makes man human: thirty-ninth James Arthur lecture on the evolution of the human brain, 1970
Karl
H
Pribram
Journal of Biomedical Discovery and Collaboration 2006, 1 :13 (29 November 2006)
Abstract | Full text | PDF | PubMed
98.
Addressing substance abuse and violence in substance use disorder treatment and batterer intervention programs
Christine
Timko,
Helen
Valenstein,
Patricia
Y
Lin,
Rudolf
H
Moos,
Gregory
L
Stuart,
Ruth
C
Cronkite
Substance Abuse Treatment, Prevention, and Policy 2012, 7 :37 (7 September 2012)
Abstract | Full text | PDF | PubMed
99.
Evolutionarily consistent families in SCOP: sequence, structure and function
Ralph
B
Pethica,
Michael
Levitt,
Julian
Gough
BMC Structural Biology 2012, 12 :27 (18 October 2012)
Abstract | Full text | PDF | PubMed
100.
Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
Reza
Ehsanian,
Carter
Van Waes,
Stephan
M
Feller
Cell Communication and Signaling 2011, 9 :13 (15 May 2011)
Abstract | Full text | PDF | PubMed