1.
Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors
Kevin
Y
Yip,
Chao
Cheng,
Nitin
Bhardwaj,
James
B
Brown,
Jing
Leng,
Anshul
Kundaje,
Joel
Rozowsky,
Ewan
Birney,
Peter
Bickel,
Michael
Snyder,
Mark
Gerstein
Genome Biology 2012, 13 :R48 (5 September 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Machine learning analysis of ENCODE data for 100 transcription factors reveals six classes of genomic regions
2.
Modeling gene expression using chromatin features in various cellular contexts
Xianjun
Dong,
Melissa
C
Greven,
Anshul
Kundaje,
Sarah
Djebali,
James
B
Brown,
Chao
Cheng,
Thomas
R
Gingeras,
Mark
Gerstein,
Roderic
Guigó,
Ewan
Birney,
Zhiping
Weng
Genome Biology 2012, 13 :R53 (5 September 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Models for linking gene expression with chromatin features vary according to cellular context and RNA measurement method
3.
The Transcription Factor Encyclopedia
Dimas
Yusuf,
Stefanie
L
Butland,
Magdalena
I
Swanson,
Eugene
Bolotin,
Amy
Ticoll,
Warren
A
Cheung,
Xiao
Cindy Zhang,
Christopher
TD
Dickman,
Debra
L
Fulton,
Jonathan
S
Lim,
Jake
M
Schnabl,
Oscar
HP
Ramos,
Mireille
Vasseur-Cognet,
Charles
N
de Leeuw,
Elizabeth
M
Simpson,
Gerhart
U
Ryffel,
Eric
W-F
Lam,
Ralf
Kist,
Miranda
SC
Wilson,
Raquel
Marco-Ferreres,
Jan
J
Brosens,
Leonardo
L
Beccari,
Paola
Bovolenta,
Bérénice
A
Benayoun,
Lara
J
Monteiro,
Helma
DC
Schwenen,
Lars
Grontved,
Elizabeth
Wederell,
Susanne
Mandrup,
Reiner
A
Veitia
et al.
Genome Biology 2012, 13 :R24 (29 March 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central |
|
Editor’s summary
A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system
4.
Model-based Analysis of ChIP-Seq (MACS)
Yong
Zhang,
Tao
Liu,
Clifford
A
Meyer,
Jérôme
Eeckhoute,
David
S
Johnson,
Bradley
E
Bernstein,
Chad
Nusbaum,
Richard
M
Myers,
Myles
Brown,
Wei
Li,
X Shirley
Liu
Genome Biology 2008, 9 :R137 (17 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
MACS performs model-based analysis of ChIP-Seq data generated by short read sequencers.
5.
The Stanford Health Assessment Questionnaire: Dimensions and Practical Applications
Bonnie
Bruce,
James
F
Fries
Health and Quality of Life Outcomes 2003, 1 :20 (9 June 2003)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
6.
An encyclopedia of mouse DNA elements (Mouse ENCODE)
John
A
Stamatoyannopoulos,
Michael
Snyder,
Ross
Hardison,
Bing
Ren,
Thomas
Gingeras,
David
M
Gilbert,
Mark
Groudine,
Michael
Bender,
Rajinder
Kaul,
Theresa
Canfield,
Erica
Giste,
Audra
Johnson,
Mia
Zhang,
Gayathri
Balasundaram,
Rachel
Byron,
Vaughan
Roach,
Peter
J
Sabo,
Richard
Sandstrom,
A Sandra
Stehling,
Robert
E
Thurman,
Sherman
M
Weissman,
Philip
Cayting,
Manoj
Hariharan,
Jin
Lian,
Yong
Cheng,
Stephen
G
Landt,
Zhihai
Ma,
Barbara
J
Wold,
Job
Dekker
et al.
Genome Biology 2012, 13 :418 (13 August 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
The Mouse ENCODE Consortium is applying the same experimental pipelines developed for human ENCODE to annotate the mouse genome
7.
Evaluation of lifestyle interventions to treat elevated cardiometabolic risk in primary care (E-LITE): a randomized controlled trial
Jun
Ma,
Abby
C
King,
Sandra
R
Wilson,
Lan
Xiao,
Randall
S
Stafford
BMC Family Practice 2009, 10 :71 (12 November 2009)
Abstract | Full text | PDF | PubMed
8.
Engineered cell-cell communication via DNA messaging
Monica
E
Ortiz,
Drew
Endy
Journal of Biological Engineering 2012, 6 :16 (7 September 2012)
Abstract | Full text | PDF | PubMed
9.
Transcriptional profiling of lncRNAs and novel transcribed regions across a diverse panel of archived human cancers
Alayne
L
Brunner,
Andrew
H
Beck,
Badreddin
Edris,
Robert
T
Sweeney,
Shirley
X
Zhu,
Rui
Li,
Kelli
Montgomery,
Sushama
Varma,
Thea
Gilks,
Xiangqian
Guo,
Joseph
W
Foley,
Daniela
M
Witten,
Craig
P
Giacomini,
Ryan
A
Flynn,
Jonathan
R
Pollack,
Robert
Tibshirani,
Howard
Y
Chang,
Matt
van de Rijn,
Robert
B
West
Genome Biology 2012, 13 :R75 (28 August 2012)
Abstract | Provisional PDF
| PubMed | Cited on BioMed Central
|
Editor’s summary
Transcript sequencings from 64 solid tumours of 17 diagnostic classes reveals cancer-specific lncRNAs
10.
What determines cell size?
Wallace
F
Marshall,
Kevin
D
Young,
Matthew
Swaffer,
Elizabeth
Wood,
Paul
Nurse,
Akatsuki
Kimura,
Joseph
Frankel,
John
Wallingford,
Virginia
Walbot,
Xian
Qu,
Adrienne
HK
Roeder
BMC Biology 2012, 10 :101 (14 December 2012)
Abstract | Full text | PDF | PubMed |
|
Editor’s summary
In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.
11.
Moving pictures of the human microbiome
J Gregory
Caporaso,
Christian
L
Lauber,
Elizabeth
K
Costello,
Donna
Berg-Lyons,
Antonio
Gonzalez,
Jesse
Stombaugh,
Dan
Knights,
Pawel
Gajer,
Jacques
Ravel,
Noah
Fierer,
Jeffrey
I
Gordon,
Rob
Knight
Genome Biology 2011, 12 :R50 (30 May 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology
|
Editor’s summary
The dynamism of microbiome populations is seen in daily samples from a landmark multi-body site, multi-individual study
12.
Are we training pit bulls to review our manuscripts?
Virginia
Walbot
Journal of Biology 2009, 8 :24 (9 March 2009)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central |
|
Editor’s summary
Virginia Walbot accepts some of the blame for remorselessly negative reviewers, and suggests a training program for graduate students and post docs that will deliver a fairer assessment of manuscripts.
13.
Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features
Ko
Tsutsui,
Takashi
Kanbayashi,
Keiko
Tanaka,
Shuken
Boku,
Wakako
Ito,
Jun
Tokunaga,
Akane
Mori,
Yasuo
Hishikawa,
Tetsuo
Shimizu,
Seiji
Nishino
BMC Psychiatry 2012, 12 :37 (8 May 2012)
Abstract | Full text | PDF | PubMed
14.
Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans
Qi
Zhou,
Hong-mei
Zhu,
Quan-fei
Huang,
Li
Zhao,
Guo-jie
Zhang,
Scott
W
Roy,
Beatriz
Vicoso,
Zhao-lin
Xuan,
Jue
Ruan,
Yue
Zhang,
Ruo-ping
Zhao,
Chen
Ye,
Xiu-qing
Zhang,
Jun
Wang,
Wen
Wang,
Doris
Bachtrog
BMC Genomics 2012, 13 :109 (22 March 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Analysis of the genome of Drosophila albomicans, shows the extremely young neo-sex chromosomes already have an accumulation of excess deleterious mutations and the B chromosomes have an origin in sex chromosome-autosome fusion.
15.
BioWarehouse: a bioinformatics database warehouse toolkit
Thomas
J
Lee,
Yannick
Pouliot,
Valerie
Wagner,
Priyanka
Gupta,
David
WJ
Stringer-Calvert,
Jessica
D
Tenenbaum,
Peter
D
Karp
BMC Bioinformatics 2006, 7 :170 (23 March 2006)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
16.
GC-Content Normalization for RNA-Seq Data
Davide
Risso,
Katja
Schwartz,
Gavin
Sherlock,
Sandrine
Dudoit
BMC Bioinformatics 2011, 12 :480 (17 December 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
The combination of three different strategies for GC-content normalization of RNA-seq data leads to more accurate estimations of gene expression levels and fold-changes, making statistical inference of differential expression less prone to false discoveries.
17.
The effect of a cold beverage during an exercise session combining both strength and energy systems development training on core temperature and markers of performance
Danielle
LaFata,
Amanda
Carlson-Phillips,
Stacy
T
Sims,
Elizabeth
M
Russell
Journal of the International Society of Sports Nutrition 2012, 9 :44 (19 September 2012)
Abstract | Full text | PDF | PubMed
18.
Gene expression patterns associated with blood-feeding in the malaria mosquito Anopheles gambiae
Ali
N
Dana,
Young
S
Hong,
Marcia
K
Kern,
Maureen
E
Hillenmeyer,
Brent
W
Harker,
Neil
F
Lobo,
James
R
Hogan,
Patricia
Romans,
Frank
H
Collins
BMC Genomics 2005, 6 :5 (14 January 2005)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Expression patterns of genes affected by the female malaria mosquito's physiological responses to blood feeding are defined.
19.
Q & A: the Snyderome
Michael
Snyder
Genome Biology 2012, 13 :147 (16 March 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Michael Snyder answers Genome Biology's questions on the human and professional stories underlying his Snyderome integrative omics project
20.
Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
Conrad
E
Johanson,
John
A
Duncan,
Petra
M
Klinge,
Thomas
Brinker,
Edward
G
Stopa,
Gerald
D
Silverberg
Cerebrospinal Fluid Research 2008, 5 :10 (14 May 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
21.
Categorization of humans in biomedical research: genes, race and disease
Neil
Risch,
Esteban
Burchard,
Elad
Ziv,
Hua
Tang
Genome Biology 2002, 3 :comment2007-comment2007.12 (1 July 2002)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
A debate has arisen regarding the validity of racial/ethnic categories for biomedical and genetic research. An epidemiologic perspective on the issue of human categorization in biomedical and genetic research strongly supports the continued use of self-identified race and ethnicity.
22.
How do miRNAs mediate translational repression?
Shuo
Gu,
Mark
A
Kay
Silence 2010, 1 :11 (7 May 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
23.
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
Aaron
M
Newman,
Natasha
B
Gallo,
Lisa
S
Hancox,
Norma
J
Miller,
Carolyn
M
Radeke,
Michelle
A
Maloney,
James
B
Cooper,
Gregory
S
Hageman,
Don
H
Anderson,
Lincoln
V
Johnson,
Monte
J
Radeke
Genome Medicine 2012, 4 :16 (24 February 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Comparative transcriptome profiling of eye specimens, integrated with functionally enriched protein network analysis reveals candidate drug targets for treating age-related macular degeneration.
24.
The real cost of sequencing: higher than you think!
Andrea
Sboner,
Xinmeng
Mu,
Dov
Greenbaum,
Raymond
K
Auerbach,
Mark
B
Gerstein
Genome Biology 2011, 12 :125 (25 August 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The sharp decrease in the cost of 'data generation' has not been matched by a comparable decrease in the cost of the computational infrastructure required to mine the data
25.
Population-specificity of human DNA methylation
Hunter
B
Fraser,
Lucia
L
Lam,
Sarah
M
Neumann,
Michael
S
Kobor
Genome Biology 2012, 13 :R8 (9 February 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Measurement of TSS-proximal DNA methylation in CEU and YRI genomes reveals significant population specificity