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151.

Research   Open Access

An in vitro-identified high-affinity nucleosome-positioning signal is capable of transiently positioning a nucleosome in vivo

Lia E Gracey, Zhi-Ying Chen, Jay M Maniar, Anton Valouev, Arend Sidow, Mark A Kay, Andrew Z Fire Epigenetics & Chromatin 2010, 3:13 (1 July 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The introduction of a synthetic high-affinity nucleosome-positioning signal into a DNA plasmid vector in mice results in the strong yet transient positioning of nucleosomes in vivo.

152.

Editorial   Free Highly Accessed

Is breast cancer a part of Lynch syndrome?

James M Ford Breast Cancer Research 2012, 14:110 (22 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

153.

Research article   Open Access Highly Accessed

Occurrence of breast cancer subtypes in adolescent and young adult women

Theresa HM Keegan, Mindy C DeRouen, David J Press, Allison W Kurian, Christina A Clarke Breast Cancer Research 2012, 14:R55 (27 March 2012)

Abstract | Full text | PDF | PubMed

154.

Methodology article   Open Access Highly Accessed

STOP using just GO: a multi-ontology hypothesis generation tool for high throughput experimentation

Tobias Wittkop, Emily TerAvest, Uday S Evani, K Fleisch, Ari E Berman, Corey Powell, Nigam H Shah, Sean D Mooney BMC Bioinformatics 2013, 14:53 (14 February 2013)

Abstract | Full text | PDF | PubMed

155.

Research article   Open Access Highly Accessed

Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

Xiaoyan Zhao, Nwora Okeke, Orr Sharpe, Franak M Batliwalla, Annette T Lee, Peggy P Ho, Beren H Tomooka, Peter K Gregersen, William H Robinson Arthritis Research & Therapy 2008, 10:R94 (18 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

156.

Review   Open Access

Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis

Mohammad Afzal Khan Multidisciplinary Respiratory Medicine 2013, 8:11 (6 February 2013)

Abstract | Full text | PDF | PubMed

157.

Correction   Open Access

Correction: Mechanisms of stomatal development: an evolutionary view

Anne Vatén, Dominique C Bergmann EvoDevo 2013, 4:11 (4 April 2013)

Abstract | Full text | PDF | PubMed

158.

Review   Open Access Highly Accessed

Africa and the global carbon cycle

Christopher A Williams, Niall P Hanan, Jason C Neff, Robert J Scholes, Joseph A Berry, A Scott Denning, David F Baker Carbon Balance and Management 2007, 2:3 (7 March 2007)

Abstract | Full text | PDF | PubMed

159.

Case Report   Open Access Highly Accessed

Complete remission of primary plasma cell leukemia with bortezomib, doxorubicin, and dexamethasone: a case report

Steven M Chan, Tracy George, Athena M Cherry, Bruno C Medeiros Cases Journal 2009, 2:121 (4 February 2009)

Abstract | Full text | PDF | PubMed

160.

Method   Open Access Highly Accessed

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

Maureen E Hillenmeyer, Elke Ericson, Ronald W Davis, Corey Nislow, Daphne Koller, Guri Giaever Genome Biology 2010, 11:R30 (12 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The relationship between co-fitness and co-inhibition of genes in chemicogenomic yeast screens provides insights into gene function and drug target prediction.

161.

Research   Open Access Highly Accessed

Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers

Robert C Spitale, Michelle Y Cheng, Kimberly A Chun, Emily S Gorell, Claudia A Munoz, Dale G Kern, Steve M Wood, Helen E Knaggs, Jacob Wulff, Kirk D Beebe, Anne Lynn S Chang Genome Medicine 2012, 4:14 (23 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A study of the effects of antioxidant dietary supplementation on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.

162.

Research article   Open Access

Atherosclerotic cardiovascular disease and dermatomyositis: an analysis of the Nationwide Inpatient Sample survey

Eleni Linos, David Fiorentino, Bharathi Lingala, Eswar Krishnan, Lorinda Chung Arthritis Research & Therapy 2013, 15:R7 (8 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Patients suffering from both dermatomyositis and an atherosclerotic cardiovascular disease (CVD) are twice as likely to die during inpatient stay compared to controls with CVD, and dermatomyositis patients without CVD.

163.

Research   Open Access

Text mining for biology - the way forward: opinions from leading scientists

Russ B Altman, Casey M Bergman, Judith Blake, Christian Blaschke, Aaron Cohen, Frank Gannon, Les Grivell, Udo Hahn, William Hersh, Lynette Hirschman, Lars Jensen, Martin Krallinger, Barend Mons, Seán I O'Donoghue, Manuel C Peitsch, Dietrich Rebholz-Schuhmann, Hagit Shatkay, Alfonso Valencia Genome Biology 2008, 9(Suppl 2):S7 (1 September 2008)

Abstract | Full text | PDF

164.

Research article   Open Access Highly Accessed

Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.

165.

Study protocol   Open Access Highly Accessed

Inhaled Nitric Oxide in preterm infants: a systematic review and individual patient data meta-analysis

Lisa M Askie, Roberta A Ballard, Gary Cutter, Carlo Dani, Diana Elbourne, David Field, Jean-Michel Hascoet, Anna Hibbs, John P Kinsella, Jean-Christophe Mercier, Wade Rich, Michael D Schreiber, Pimol Srisuparp, Nim V Subhedar, Krisa P Van Meurs, Merryn Voysey, Keith Barrington, Richard A Ehrenkranz, Neil Finer, BMC Pediatrics 2010, 10:15 (23 March 2010)

Abstract | Full text | PDF | PubMed

166.

Research   Open Access Highly Accessed

A Meta-analysis of the effects of Exercise Training on Left Ventricular Remodeling Following Myocardial Infarction: Start early and go longer for greatest exercise benefits on remodeling

Mark Haykowsky, Jessica Scott, Ben Esch, Don Schopflocher, Jonathan Myers, Ian Paterson, Darren Warburton, Lee Jones, Alexander M Clark Trials 2011, 12:92 (4 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

167.

Research article   Open Access Highly Accessed

Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development

James F Fries, Eswar Krishnan Arthritis Res Ther 2004, 6:R250-R255 (18 March 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The 'uncertainty principle' states that randomised controlled trials are only ethical if true uncertainty exists about which treatment is likely to be superior. Is this principle being violated in industry-sponsored trials?

168.

Software   Open Access Highly Accessed

Tools for loading MEDLINE into a local relational database

Diane E Oliver, Gaurav Bhalotia, Ariel S Schwartz, Russ B Altman, Marti A Hearst BMC Bioinformatics 2004, 5:146 (7 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

169.

Review   Open Access Highly Accessed

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria

Christopher V Plowe, Cally Roper, John W Barnwell, Christian T Happi, Hema H Joshi, Wilfred Mbacham, Steven R Meshnick, Kefas Mugittu, Inbarani Naidoo, Ric N Price, Robert W Shafer, Carol H Sibley, Colin J Sutherland, Peter A Zimmerman, Philip J Rosenthal Malaria Journal 2007, 6:121 (6 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The review describes previous successes on using molecular markers of drug resistance and lessons learned. A standardized global database of molecular markers of drug resistance linking up with databases containing in vivo efficacy trial results, in vitro and pharmacokinetic studies could form an essential resource to guide policy makers in choice of first line antimalarial drugs, drugs for intermittent preventive treatment (IPT) and prophylactic drugs for travellers.

170.

Research article   Open Access Highly Accessed

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

Aaron L Sarver, Amy J French, Pedro M Borralho, Venugopal Thayanithy, Ann L Oberg, Kevin AT Silverstein, Bruce W Morlan, Shaun M Riska, Lisa A Boardman, Julie M Cunningham, Subbaya Subramanian, Liang Wang, Tom C Smyrk, Cecilia MP Rodrigues, Stephen N Thibodeau, Clifford J Steer BMC Cancer 2009, 9:401 (18 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

171.

Method   Open Access Highly Accessed

An ontology for cell types

Jonathan Bard, Seung Y Rhee, Michael Ashburner Genome Biology 2005, 6:R21 (14 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An ontology for cell types that covers the prokaryotic, fungal, animal and plant worlds is described. It includes over 680 cell types. These cell types are classified under several generic categories and are organized as a directed acyclic graph.

172.

Software   Open Access Highly Accessed

Isolation by distance, web service

Jeffrey L Jensen, Andrew J Bohonak, Scott T Kelley BMC Genetics 2005, 6:13 (11 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

173.

Editorial   Open Access Highly Accessed

Changing computational research. The challenges ahead

Cameron Neylon, Jan Aerts, C Brown, Simon J Coles, Les Hatton, Daniel Lemire, K Millman, Peter Murray-Rust, Fernando Perez, Neil Saunders, Nigam Shah, Arfon Smith, Gaël Varoquaux, Egon Willighagen Source Code for Biology and Medicine 2012, 7:2 (28 May 2012)

Abstract | Full text | PDF | PubMed

174.

Research article   Open Access Highly Accessed

Restoration of disk height through non-surgical spinal decompression is associated with decreased discogenic low back pain: a retrospective cohort study

Christian C Apfel, Ozlem S Cakmakkaya, William Martin, Charlotte Richmond, Alex Macario, Elizabeth George, Maximilian Schaefer, Joseph V Pergolizzi BMC Musculoskeletal Disorders 2010, 11:155 (8 July 2010)

Abstract | Full text | PDF | PubMed

175.

Research article   Open Access Highly Accessed

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Dong Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi, William H Robinson Arthritis Research & Therapy 2012, 14:R7 (8 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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