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226.

Review   Free Highly Accessed

Direct sequencing of the human microbiome readily reveals community differences

Justin Kuczynski, Elizabeth K Costello, Diana R Nemergut, Jesse Zaneveld, Christian L Lauber, Dan Knights, Omry Koren, Noah Fierer, Scott T Kelley, Ruth E Ley, Jeffrey I Gordon, Rob Knight Genome Biology 2010, 11:210 (5 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Future sequencing of the human microbiota will require greater breadth rather than depth.

227.

Methodology   Open Access

Fluorescence resonance energy transfer sensors for quantitative monitoring of pentose and disaccharide accumulation in bacteria

Thijs Kaper, Ida Lager, Loren L Looger, Diane Chermak, Wolf B Frommer Biotechnology for Biofuels 2008, 1:11 (3 June 2008)

Abstract | Full text | PDF | PubMed

228.

Research article   Open Access Highly Accessed

Multi-exon deletions of the FBN1 gene in Marfan syndrome

Wanguo Liu, Iris Schrijver, Thomas Brenn, Heinz Furthmayr, Uta Francke BMC Medical Genetics 2001, 2:11 (24 October 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

229.

Research   Open Access

Pitting of malaria parasites and spherocyte formation

Samuel B Anyona, Stanley L Schrier, Charity W Gichuki, John N Waitumbi Malaria Journal 2006, 5:64 (31 July 2006)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A tantalizing hypothesis about the relationship between the pitting of malarial parasites and spherocyte formation during malarial infection. This hypothesis, based on in vitro studies, is supported by preliminary clinical findings and is novel inasmuch as it does not recognize a role for the spleen in the process.

230.

Commentary   Open Access

Report from the second cytomegalovirus and immunosenescence workshop

Mark Wills, Arne Akbar, Mark Beswick, Jos A Bosch, Calogero Caruso, Giuseppina Colonna-Romano, Ambarish Dutta, Claudio Franceschi, Tamas Fulop, Effrossyni Gkrania-Klotsas, Joerg Goronzy, Stephen J Griffiths, Sian M Henson, Dietmar Herndler-Brandstetter, Ann Hill, Florian Kern, Paul Klenerman, Derek Macallan, Richard Macaulay, Andrea B Maier, Gavin Mason, David Melzer, Matthew Morgan, Paul Moss, Janko Nikolich-Zugich, Annette Pachnio, Natalie Riddell, Ryan Roberts, Paolo Sansoni, Delphine Sauce, John Sinclair, Rafael Solana, Jan Strindhall, Piotr Trzonkowski, Rene van Lier, Rosanna Vescovini, George Wang, Rudi Westendorp, Graham Pawelec et al. Immunity & Ageing 2011, 8:10 (28 October 2011)

Abstract | Full text | PDF

231.

Research   Open Access Highly Accessed

The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells

Brian A Zabel, Susanna Lewén, Robert D Berahovich, Juan C Jaén, Thomas J Schall Molecular Cancer 2011, 10:73 (14 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

232.

Methodology   Open Access

Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment

Helena Okulski, Birgit Druck, Sheetal Bhalerao, Leonie Ringrose Epigenetics & Chromatin 2011, 4:4 (16 March 2011)

Abstract | Full text | PDF | PubMed

233.

Research   Open Access Highly Accessed

Metabolic-network-driven analysis of bacterial ecological strategies

Shiri Freilich, Anat Kreimer, Elhanan Borenstein, Nir Yosef, Roded Sharan, Uri Gophna, Eytan Ruppin Genome Biology 2009, 10:R61 (5 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Bacterial ecological strategies revealed by metabolic network analysis show that ecological diversity correlates with metabolic flexibility, faster growth rate and intense co-habitation.

234.

Research article   Open Access Highly Accessed

Development and evaluation of a cultural competency training curriculum

David H Thom, Miguel D Tirado, Tommy L Woon, Melen R McBride BMC Medical Education 2006, 6:38 (26 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

235.

Research   Open Access Highly Accessed

Measurement of a model of implementation for health care: toward a testable theory

Joan M Cook, Casey O’Donnell, Stephanie Dinnen, James C Coyne, Josef I Ruzek, Paula P Schnurr Implementation Science 2012, 7:59 (3 July 2012)

Abstract | Full text | PDF | PubMed

236.

Research   Open Access

Evaluation of text-mining systems for biology: overview of the Second BioCreative community challenge

Martin Krallinger, Alexander Morgan, Larry Smith, Florian Leitner, Lorraine Tanabe, John Wilbur, Lynette Hirschman, Alfonso Valencia Genome Biology 2008, 9(Suppl 2):S1 (1 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

237.

Research   Open Access Highly Accessed

Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer

Martin Buess, Dimitry SA Nuyten, Trevor Hastie, Torsten Nielsen, Robert Pesich, Patrick O Brown Genome Biology 2007, 8:R191 (14 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In an effort to deconvolute global gene-expression profiles, an interaction between some breast cancer cells and stromal fibroblasts was found to induce an interferon response, which may be associated with a greater propensity for tumor progression.

238.

Research   Open Access Highly Accessed

Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli

Brian J Peter, Javier Arsuaga, Adam M Breier, Arkady B Khodursky, Patrick O Brown, Nicholas R Cozzarelli Genome Biology 2004, 5:R87 (1 November 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Microarray analysis shows that transcription of 306 E. Coli genes is affected by changes in the level of chromosome supercoiling, suggesting that supercoiling transmits regulatory signals from the environment to many cellular pathways.

239.

Research Article   Open Access

Accelerating Seismic Computations Using Customized Number Representations on FPGAs

Haohuan Fu, William Osborne, RobertG Clapp, Oskar Mencer, Wayne Luk EURASIP Journal on Embedded Systems 2009, 2009:382983 (10 December 2008)

Abstract | Full text | PDF

240.

Research   Open Access Highly Accessed

Male reproductive development: gene expression profiling of maize anther and pollen ontogeny

Jiong Ma, David S Skibbe, John Fernandes, Virginia Walbot Genome Biology 2008, 9:R181 (19 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Analysis of global gene expression profiles of seven stages of maize anther development reveals expression of many genes

241.

Research article   Open Access Highly Accessed

The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer

Esther M John, John L Hopper, Jeanne C Beck, Julia A Knight, Susan L Neuhausen, Ruby T Senie, Argyrios Ziogas, Irene L Andrulis, Hoda Anton-Culver, Norman Boyd, Saundra S Buys, Mary B Daly, Frances P O'Malley, Regina M Santella, Melissa C Southey, Vickie L Venne, Deon J Venter, Dee W West, Alice S Whittemore, Daniela Seminara, Breast Cancer Res 2004, 6:R375-R389 (19 May 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

242.

Research   Open Access

Walkability parameters, active transportation and objective physical activity: moderating and mediating effects of motor vehicle ownership in a cross-sectional study

Ulf Eriksson, Daniel Arvidsson, Klaus Gebel, Henrik Ohlsson, Kristina Sundquist International Journal of Behavioral Nutrition and Physical Activity 2012, 9:123 (5 October 2012)

Abstract | Full text | PDF | PubMed

243.

Review   Open Access

Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia

Jan M Eckermann, Paul R Krafft, Lorelei Shoemaker, Robert E Lieberson, Steven D Chang, Austin Colohan Medical Gas Research 2012, 2:11 (19 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

244.

Research article   Open Access

Predicting environmental chemical factors associated with disease-related gene expression data

Chirag J Patel, Atul J Butte BMC Medical Genomics 2010, 3:17 (6 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

245.

Research article   Open Access

A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses

Xuefeng B Ling, Kenneth Lau, John T Kanegaye , Zheng Pan, Sihua Peng, Jun Ji, Gigi Liu, Yuichiro Sato, Tom TS Yu, John C Whitin, James Schilling, Jane C Burns, Harvey J Cohen BMC Medicine 2011, 9:130 (6 December 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Diagnosis of Kawasaki disease, an acute vasculitis of infants and young children characterized by an array of symptoms that can mimic other benign conditions, may be easier with a new multi-step algorithm

246.

Research   Open Access Highly Accessed

Identification of sepsis subtypes in critically ill adults using gene expression profiling

David M Maslove, Benjamin M Tang, Anthony S McLean Critical Care 2012, 16:R183 (4 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

247.

Research article   Open Access Highly Accessed

Cardiovascular diseases and Type 2 Diabetes in Bangladesh: A systematic review and meta-analysis of studies between 1995 and 2010

Nazmus Saquib, Juliann Saquib, Tahmeed Ahmed, Masuma Khanam, Mark R Cullen BMC Public Health 2012, 12:434 (13 June 2012)

Abstract | Full text | PDF | PubMed

248.

Research   Open Access

Human and environmental controls over aboveground carbon storage in Madagascar

Gregory P Asner, John K Clark, Joseph Mascaro, Romuald Vaudry, K Dana Chadwick, Ghislain Vieilledent, Maminiaina Rasamoelina, Aravindh Balaji, Ty Kennedy-Bowdoin, Léna Maatoug, Matthew S Colgan, David E Knapp Carbon Balance and Management 2012, 7:2 (30 January 2012)

Abstract | Full text | PDF | PubMed

249.

Research   Open Access Highly Accessed

Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent

Crissey L Pascale, Miles C Miller, Catherine Chiu, Matthew Boylan, Ilias N Caralopoulos, Liliana Gonzalez, Conrad E Johanson, Gerald D Silverberg Fluids and Barriers of the CNS 2011, 8:21 (8 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Amyloid-beta peptide efflux transporters are significantly increased at the blood-cerebrospinal fluid barrier with advancing age, suggesting a role in the prevention of amyloid-beta peptide accumulation and associated neurodegenerative disease.

250.

Methodology   Open Access

A proteomic approach for the identification of novel lysine methyltransferase substrates

Dan Levy, Chih Long Liu, Ze Yang, Aaron M Newman, Ash A Alizadeh, Paul J Utz, Or Gozani Epigenetics & Chromatin 2011, 4:19 (24 October 2011)

Abstract | Full text | PDF | PubMed

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