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1.

2184
Accesses

Regular article   Open Access

Long trend dynamics in social media

Chunyan Wang, Bernardo A Huberman EPJ Data Science 2012, 1:2 (18 May 2012)

Abstract | Full text | PDF

2.

2094
Accesses

Research   Open Access

Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure

Dale Muzzey, Katja Schwartz, Jonathan S Weissman, Gavin Sherlock Genome Biology 2013, 14:R97 (11 September 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

An assembly of a diploid Candida albicans phased genome helps detect allele-specific events and significantly expands the number of known polymorphisms

3.

1924
Accesses

Musings   Subscription Highly Accessed

Circulating tumor cells versus tumor-derived cell-free DNA: rivals or partners in cancer care in the era of single-cell analysis?

Evelyn Kidess, Stefanie S Jeffrey Genome Medicine 2013, 5:70 (13 August 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Evelyn Kidess and Stefanie Jeffrey muse on the future uses of cell-free DNA and circulating tumor cells in cancer care and speculate that they will be employed at different treatment steps.

4.

1884
Accesses

Research article   Open Access Highly Accessed

Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae

Diane O Inglis, Jonathan Binkley, Marek S Skrzypek, Martha B Arnaud, Gustavo C Cerqueira, Prachi Shah, Farrell Wymore, Jennifer R Wortman, Gavin Sherlock BMC Microbiology 2013, 13:91 (26 April 2013)

Abstract | Full text | PDF | PubMed

5.

1857
Accesses

Research   Open Access Highly Accessed

Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism

Yong-Tao Lv, Yun Zhang, Min Liu, Jia-na-ti Qiuwaxi, Paul Ashwood, Sungho Cho, Ying Huan, Ru-Cun Ge, Xing-Wang Chen, Zhao-Jing Wang, Byung-Jo Kim, Xiang Hu Journal of Translational Medicine 2013, 11:196 (27 August 2013)

Abstract | Full text | PDF | PubMed

6.

1712
Accesses

Review   Open Access Highly Accessed

The Stanford Health Assessment Questionnaire: Dimensions and Practical Applications

Bonnie Bruce, James F Fries Health and Quality of Life Outcomes 2003, 1:20 (9 June 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

1497
Accesses

Research article   Open Access Highly Accessed

Visual inspection with acetic acid as a cervical cancer test: accuracy validated using latent class analysis

Lynne Gaffikin, John A McGrath, Marc Arbyn, Paul D Blumenthal BMC Medical Research Methodology 2007, 7:36 (31 July 2007)

Abstract | Full text | PDF | PubMed | 1 comment

8.

1475
Accesses

Review   Open Access Highly Accessed

Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

Conrad E Johanson, John A Duncan, Petra M Klinge, Thomas Brinker, Edward G Stopa, Gerald D Silverberg Cerebrospinal Fluid Research 2008, 5:10 (14 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

1464
Accesses

Research   Open Access Highly Accessed

A survey of enabling technologies in synthetic biology

Linda J Kahl, Drew Endy Journal of Biological Engineering 2013, 7:13 (10 May 2013)

Abstract | Full text | PDF | PubMed

10.

1427
Accesses

Research article   Open Access Highly Accessed

Family history of later-onset breast cancer, breast healthy behavior and invasive breast cancer among postmenopausal women: a cohort study

Robert Gramling, Timothy L Lash, Kenneth J Rothman, Howard J Cabral, Rebecca Silliman, Mary Roberts, Marcia L Stefanick, Rosanne Harrigan, Monica L Bertoia, Charles B Eaton Breast Cancer Research 2010, 12:R82 (12 October 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Adhering to 'breast healthy' behaviours such as maintaining healthy body weight, being physically active and limiting alcohol intake benefited women with and without a family history of later-onset breast cancer.

11.

1237
Accesses

Forum   Open Access Highly Accessed

What determines cell size?

Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu, Adrienne HK Roeder BMC Biology 2012, 10:101 (14 December 2012)

Abstract | Full text | PDF | PubMed | 2 comments |  Editor’s summary

In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.

12.

1197
Accesses

Method   Open Access Highly Accessed

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang, Tao Liu, Clifford A Meyer, Jérôme Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley Liu Genome Biology 2008, 9:R137 (17 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

MACS performs model-based analysis of ChIP-Seq data generated by short read sequencers.

13.

1188
Accesses

Research   Open Access Highly Accessed

Gene expression changes with age in skin, adipose tissue, blood and brain

Daniel Glass, Ana Viñuela, Matthew N Davies, Adaikalavan Ramasamy, Leopold Parts, David Knowles, Andrew A Brown, Åsa K Hedman, Kerrin S Small, Alfonso Buil, Elin Grundberg, Alexandra C Nica, PaolaDi Meglio, Frank O Nestle, Mina Ryten, Richard Durbin, Mark I McCarthy, Panagiotis Deloukas, Emmanouil T Dermitzakis, Michael E Weale, Veronique Bataille, Tim D Spector Genome Biology 2013, 14:R75 (26 July 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Analysis of microarray experiments in subjects of varying age shows that gene expression in four different tissues changes with time

14.

1179
Accesses

Research article   Open Access

A method for inferring medical diagnoses from patient similarities

Assaf Gottlieb, Gideon Y Stein, Eytan Ruppin, Russ B Altman, Roded Sharan BMC Medicine 2013, 11:194 (2 September 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A new method using detailed population based information in electronic health records, can accurately predict discharge diagnosis of patients with acute and chronic diseases and can assist physicians with medical decisions.

15.

1074
Accesses

Research article   Open Access Highly Accessed

Integrative genomic and functional profiling of the pancreatic cancer genome

A Shain, Keyan Salari, Craig P Giacomini, Jonathan R Pollack BMC Genomics 2013, 14:624 (16 September 2013)

Abstract | Full text | PDF | PubMed

16.

1009
Accesses

Research   Open Access Highly Accessed

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers

Alayne L Brunner, Andrew H Beck, Badreddin Edris, Robert T Sweeney, Shirley X Zhu, Rui Li, Kelli Montgomery, Sushama Varma, Thea Gilks, Xiangqian Guo, Joseph W Foley, Daniela M Witten, Craig P Giacomini, Ryan A Flynn, Jonathan R Pollack, Robert Tibshirani, Howard Y Chang, Matt van de Rijn, Robert B West Genome Biology 2012, 13:R75 (28 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Transcript sequencings from 64 solid tumours of 17 diagnostic classes reveals cancer-specific lncRNAs

17.

982
Accesses

Research article   Open Access Highly Accessed

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

Chih Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh, Paul J Utz Arthritis Research & Therapy 2012, 14:R25 (2 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

960
Accesses

Research article   Open Access Highly Accessed

Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila

Penelope Coggill, Ruth Y Eberhardt, Robert D Finn, Yuanyuan Chang, Lukasz Jaroszewski, Adam Godzik, Debanu Das, Qingping Xu, Herbert L Axelrod, L Aravind, Alexey G Murzin, Alex Bateman BMC Bioinformatics 2013, 14:265 (3 September 2013)

Abstract | Full text | PDF | PubMed

19.

933
Accesses

Review   Open Access Highly Accessed

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

Philipp A Jaeger, Tony Wyss-Coray Molecular Neurodegeneration 2009, 4:16 (6 April 2009)

Abstract | Full text | PDF | PubMed

20.

927
Accesses

Research highlight   Subscription Highly Accessed

Microbiota's 'little helpers': bacteriophages and antibiotic-associated responses in the gut microbiome

Christine L Sun, David A Relman Genome Biology 2013, 14:127 (30 July 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

David Relman and Christine Sun discuss recent research into how bacteriophage mediate the impact of antibiotics on the gut microbiome

21.

888
Accesses

Research article   Open Access Highly Accessed

Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized controlled trial

Vibeke Strand, Philip Mease, Gerd R Burmester, Enkeleida Nikaï, Geoffroy Coteur, Ronald van Vollenhoven, Bernard Combe, Edward C Keystone, Arthur Kavanaugh Arthritis Research & Therapy 2009, 11:R170 (12 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

879
Accesses

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

23.

875
Accesses

Research   Open Access

Comparison of the canine and human olfactory receptor gene repertoires

Pascale Quignon, Ewen Kirkness, Edouard Cadieu, Nizar Touleimat, Richard Guyon, Corinne Renier, Christophe Hitte, Catherine André, Claire Fraser, Francis Galibert Genome Biology 2003, 4:R80 (28 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In this study, 817 novel canine olfactory receptor (OR) sequences were identified, and 640 have been characterized. Of the 661 characterized OR sequences, representing half of the canine repertoire, 18% are predicted to be pseudogenes, compared with 63% in human and 20% in mouse.

24.

866
Accesses

Research article   Open Access Highly Accessed

A survey study of the association between mobile phone use and daytime sleepiness in California high school students

Nila Nathan, Jamie Zeitzer BMC Public Health 2013, 13:840 (12 September 2013)

Abstract | Full text | PDF | PubMed

25.

849
Accesses

Research   Open Access Highly Accessed

Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status

Jason P Awe, Patrick C Lee, Cyril Ramathal, Agustin Vega-Crespo, Jens Durruthy-Durruthy, Aaron Cooper, Saravanan Karumbayaram, William E Lowry, Amander T Clark, Jerome A Zack, Vittorio Sebastiano, Donald B Kohn, April D Pyle, Martin G Martin, Gerald S Lipshutz, Patricia E Phelps, Renee A Reijo Pera, James A Byrne Stem Cell Research & Therapy 2013, 4:87 (26 July 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Transgene-free human induced pluripotent stem cells (iPSCs) generated using the stem cell cassette vector were fully characterized, differentiated into therapeutically relevant cell lineages, and converted to putative clinical-grade conditions.

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