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1.

Research   Open Access Highly Accessed

Management of bleeding and coagulopathy following major trauma: an updated European guideline

Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2013, 17:R76 (19 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Task Force for Advanced Bleeding Care in Trauma have updated their guidelines on the management of bleeding following traumatic injury, with new recommendations addressing changes made in clinical care.

2.

Research   Open Access Highly Accessed

Renaissance of base deficit for the initial assessment of trauma patients: a base deficit-based classification for hypovolemic shock developed on data from 16,305 patients derived from the TraumaRegister DGU®

Manuel Mutschler, Ulrike Nienaber, Thomas Brockamp, Arasch Wafaisade, Tobias Fabian, Thomas Paffrath, Bertil Bouillon, Marc Maegele, Critical Care 2013, 17:R42 (6 March 2013)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Base deficit (BD)-based shock classification better discriminates the need for early blood transfusion and mortality in severely injured patients than the current Advanced Trauma Life Support (ATLS) protocol.

3.

Research   Open Access Highly Accessed

Management of bleeding following major trauma: an updated European guideline

Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Philip F Stahel, Jean-Louis Vincent, Donat R Spahn Critical Care 2010, 14:R52 (6 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

Research   Open Access Highly Accessed

Management of bleeding following major trauma: a European guideline

Donat R Spahn, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Giovanni Gordini, Philip F Stahel, Beverley J Hunt, Radko Komadina, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2007, 11:R17 (13 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

State-of-the-art guidelines developed by a multidisciplinary task force provide evidence-based recommendations on the acute management of bleeding trauma patients, which when implemented may lead to improved patient outcomes.

5.

Correspondence   Open Access Highly Accessed

How to locate and appraise qualitative research in complementary and alternative medicine

Brigitte Franzel, Martina Schwiegershausen, Peter Heusser, Bettina Berger BMC Complementary and Alternative Medicine 2013, 13:125 (3 June 2013)

Abstract | Provisional PDF | PubMed

6.

Commentary   Subscription Highly Accessed

The STOP the Bleeding Campaign

Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Marc Maegele, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Donat R Spahn, Critical Care 2013, 17:136 (26 April 2013)

Abstract | Full text | PDF | PubMed

7.

Research article   Open Access

Individualised medicine from the perspectives of patients using complementary therapies: a meta-ethnography approach

Brigitte Franzel, Martina Schwiegershausen, Peter Heusser, Bettina Berger BMC Complementary and Alternative Medicine 2013, 13:124 (3 June 2013)

Abstract | Full text | PDF | PubMed

8.

Research article   Open Access Highly Accessed

Safety of higher dosages of Viscum album L. in animals and humans - systematic review of immune changes and safety parameters

Gunver S Kienle, Renate Grugel, Helmut Kiene BMC Complementary and Alternative Medicine 2011, 11:72 (28 August 2011)

Abstract | Full text | PDF | PubMed

9.

Review   Open Access Highly Accessed

A systematic review on the impact of leg ulceration on patients' quality of life

Oliver R Herber, Wilfried Schnepp, Monika A Rieger Health and Quality of Life Outcomes 2007, 5:44 (25 July 2007)

Abstract | Full text | PDF | PubMed | 2 comments

10.

Research article   Open Access Highly Accessed

Patient and physician related factors of adherence to evidence based guidelines in diabetes mellitus type 2, cardiovascular disease and prevention: a cross sectional study

Johanna Fürthauer, Maria Flamm, Andreas Sönnichsen BMC Family Practice 2013, 14:47 (4 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Guidelines for treating chronic conditions like diabetes are followed in the majority of cases, but adherence could still be increased by improving doctors knowledge and patients awareness of these guidelines

11.

Research article   Open Access Highly Accessed

Is Europe putting theory into practice? A qualitative study of the level of self-management support in chronic care management approaches

Arianne Elissen, Ellen Nolte, Cécile Knai, Matthias Brunn, Karine Chevreul, Annalijn Conklin, Isabelle Durand-Zaleski, Antje Erler, Maria Flamm, Anne Frølich, Birgit Fullerton, Ramune Jacobsen, Zuleika Saz-Parkinson, Antonio Sarria-Santamera, Andreas Sönnichsen, Hubertus Vrijhoef BMC Health Services Research 2013, 13:117 (26 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A study of self-management support approaches in Europe suggests a need for better understanding of how to encourage patients and health care providers to engage in productive interactions in daily chronic care practice.

12.

Research   Open Access Highly Accessed

The economics of primary prevention of cardiovascular disease – a systematic review of economic evaluations

David LB Schwappach, Till A Boluarte, Marc Suhrcke Cost Effectiveness and Resource Allocation 2007, 5:5 (14 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

Study protocol   Open Access

The effects of dementia care mapping on nursing home residents' quality of life and staff attitudes: design of the quasi-experimental study Leben-QD II

Margareta Halek, Martin Nikolaus Dichter, Tina Quasdorf, Christine Riesner, Sabine Bartholomeyczik BMC Geriatrics 2013, 13:53 (1 June 2013)

Abstract | Provisional PDF | PubMed

14.

Research article   Open Access Highly Accessed

Effects of music therapy in the treatment of children with delayed speech development - results of a pilot study

Wibke Groß, Ulrike Linden, Thomas Ostermann BMC Complementary and Alternative Medicine 2010, 10:39 (21 July 2010)

Abstract | Full text | PDF | PubMed

15.

Resource review   Open Access Highly Accessed

CAMbase – A XML-based bibliographical database on Complementary and Alternative Medicine (CAM)

Thomas Ostermann, Hartmut Zillmann, Christa K Raak, Arndt Buessing, Peter F Matthiessen Biomedical Digital Libraries 2007, 4:2 (3 April 2007)

Abstract | Full text | PDF | PubMed

16.

Correspondence   Open Access Highly Accessed

Checklist for the qualitative evaluation of clinical studies with particular focus on external validity and model validity

Gudrun Bornhöft, Stefanie Maxion-Bergemann, Ursula Wolf, Gunver S Kienle, Andreas Michalsen, Horst C Vollmar, Simon Gilbertson, Peter F Matthiessen BMC Medical Research Methodology 2006, 6:56 (11 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

Review   Open Access Highly Accessed

A unified phylogeny-based nomenclature for histone variants

Paul B Talbert, Kami Ahmad, Geneviève Almouzni, Juan Ausió, Frederic Berger, Prem L Bhalla, William M Bonner, W Cande, Brian P Chadwick, Simon W L Chan, George A M Cross, Liwang Cui, Stefan I Dimitrov, Detlef Doenecke, José M Eirin-López, Martin A Gorovsky, Sandra B Hake, Barbara A Hamkalo, Sarah Holec, Steven E Jacobsen, Kinga Kamieniarz, Saadi Khochbin, Andreas G Ladurner, David Landsman, John A Latham, Benjamin Loppin, Harmit S Malik, William F Marzluff, John R Pehrson, Jan Postberg et al. Epigenetics & Chromatin 2012, 5:7 (31 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In response to an urgent need to rationalize the current schemes for naming histone variants, researchers from over 30 institutions worldwide have developed consistent but flexible naming rules that are informative and database-searchable.

18.

Research   Open Access

Knee injuries in severe trauma patients: a trauma registry study in 3.458 patients

Hagen Andruszkow, Emmanouil Liodakis, Rolf Lefering, Christian Krettek, Frank Hildebrand, Carl Haasper, Journal of Trauma Management & Outcomes 2012, 6:7 (6 August 2012)

Abstract | Full text | PDF | PubMed

19.

Original research   Open Access

Predictors of pulmonary failure following severe trauma: a trauma registry-based analysis

Emanuel V Geiger, Thomas Lustenberger, Sebastian Wutzler, Rolf Lefering, Mark Lehnert, Felix Walcher, Helmut L Laurer, Ingo Marzi, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2013, 21:34 (22 April 2013)

Abstract | Full text | PDF | PubMed

20.

Research article   Open Access Highly Accessed

Rotational alignment of the tibial component in total knee arthroplasty is better at the medial third of tibial tuberosity than at the medial border

Jörg Lützner, Frank Krummenauer, Klaus-Peter Günther, Stephan Kirschner BMC Musculoskeletal Disorders 2010, 11:57 (25 March 2010)

Abstract | Full text | PDF | PubMed

21.

Research   Open Access Highly Accessed

Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate

Herbert Schöchl, Ulrike Nienaber, Georg Hofer, Wolfgang Voelckel, Csilla Jambor, Gisela Scharbert, Sibylle Kozek-Langenecker, Cristina Solomon Critical Care 2010, 14:R55 (7 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

Original research   Open Access Highly Accessed

The Utstein template for uniform reporting of data following major trauma: A joint revision by SCANTEM, TARN, DGU-TR and RITG

Kjetil G Ringdal, Timothy J Coats, Rolf Lefering, Stefano Di Bartolomeo, Petter Steen, Olav Røise, Lauri Handolin, Hans Lossius, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2008, 16:7 (28 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment | F1000 Medicine | F1000 Biology

23.

Research   Open Access Highly Accessed

Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy

Herbert Schöchl, Ulrike Nienaber, Marc Maegele, Gerald Hochleitner, Florian Primavesi, Beatrice Steitz, Christian Arndt, Alexander Hanke, Wolfgang Voelckel, Cristina Solomon Critical Care 2011, 15:R83 (4 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Review   Open Access Highly Accessed

Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research

Gunver S Kienle, Anja Glockmann, Michael Schink, Helmut Kiene Journal of Experimental & Clinical Cancer Research 2009, 28:79 (11 June 2009)

Abstract | Full text | PDF | PubMed

25.

Research article   Open Access Highly Accessed

pEPito: a significantly improved non-viral episomal expression vector for mammalian cells

Rudolf Haase, Orestis Argyros, Suet-Ping Wong, Richard P Harbottle, Hans J Lipps, Manfred Ogris, Terese Magnusson, Maria Pinto, Jürgen Haas, Armin Baiker BMC Biotechnology 2010, 10:20 (15 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

pEPito, a novel non-viral protein expression vector is significantly smaller, contains only one transcription unit and 60% less CpG motives in comparison to the prototype pEPI-1 vector, considerably improving efficacy both in vitro and in vivo.

26.

Research article   Open Access Highly Accessed

Survival of cancer patients treated with mistletoe extract (Iscador): a systematic literature review

Thomas Ostermann, Christa Raak, Arndt Büssing BMC Cancer 2009, 9:451 (18 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

Research   Open Access

The oral mucosal surface and blood vessels

Ella A Naumova, Tobias Dierkes, Jürgen Sprang, Wolfgang H Arnold Head & Face Medicine 2013, 9:8 (12 March 2013)

Abstract | Full text | PDF | PubMed

28.

Research   Open Access

Does the care dependency of nursing home residents influence their health-related quality of life?-A cross-sectional study

Manuela Tabali, Thomas Ostermann, Elke Jeschke, Theo Dassen, Cornelia Heinze Health and Quality of Life Outcomes 2013, 11:41 (11 March 2013)

Abstract | Full text | PDF | PubMed

29.

Original investigation   Open Access Highly Accessed

Elevated plasma levels of TNF-alpha and Interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders

Wilfried Dinh, Reiner Füth, Werner Nickl, Thomas Krahn, Peter Ellinghaus, Thomas Scheffold, Lars Bansemir, Alexander Bufe, Michael Coll Barroso, Mark Lankisch Cardiovascular Diabetology 2009, 8:58 (12 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

Research   Open Access

A permissive chromatin structure is adopted prior to site-specific DNA demethylation of developmentally expressed genes involved in macronuclear differentiation

Aneta Bulic, Jan Postberg, Andreas Fischer, Franziska Jönsson, Günter Reuter, Hans J Lipps Epigenetics & Chromatin 2013, 6:5 (5 March 2013)

Abstract | Full text | PDF | PubMed

31.

Research article   Open Access

Evidence for the use of Levomepromazine for symptom control in the palliative care setting: a systematic review

Isabel Dietz, Andrea Schmitz, Ingrid Lampey, Christian Schulz BMC Palliative Care 2013, 12:2 (19 January 2013)

Abstract | Full text | PDF | PubMed

32.

Research   Open Access

Conscious Presence and Self Control as a measure of situational awareness in soldiers – A validation study

Arndt Büssing, Harald Walach, Niko Kohls, Fred Zimmermann, Marion Trousselard International Journal of Mental Health Systems 2013, 7:1 (7 January 2013)

Abstract | Full text | PDF | PubMed

33.

Research article   Open Access Highly Accessed

The european primary care monitor: structure, process and outcome indicators

Dionne S Kringos, Wienke GW Boerma, Yann Bourgueil, Thomas Cartier, Toralf Hasvold, Allen Hutchinson, Margus Lember, Marek Oleszczyk, Danica Pavlic, Igor Svab, Paolo Tedeschi, Andrew Wilson, Adam Windak, Toni Dedeu, Stefan Wilm BMC Family Practice 2010, 11:81 (27 October 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A standardized set of indicators for describing primary care systems is developed based on scientific evidence and consensus among an international panel of experts, suitable for Europe-wide comparison of primary care systems.

34.

Review   Open Access Highly Accessed

Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration

Kerstin Lang, Janina Ratke Cell Communication and Signaling 2009, 7:27 (23 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

Research article   Open Access Highly Accessed

Adaptive coping strategies in patients with chronic pain conditions and their interpretation of disease

Arndt Büssing, Thomas Ostermann, Edmund AM Neugebauer, Peter Heusser BMC Public Health 2010, 10:507 (20 August 2010)

Abstract | Full text | PDF | PubMed

36.

Review   Open Access

Extravasation of leukocytes in comparison to tumor cells

Carina Strell, Frank Entschladen Cell Communication and Signaling 2008, 6:10 (4 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

Technical advance   Open Access

Anterior cruciate ligament (ACL) reconstruction with quadriceps tendon autograft and press-fit fixation using an anteromedial portal technique

Ralph Akoto, Juergen Hoeher BMC Musculoskeletal Disorders 2012, 13:161 (27 August 2012)

Abstract | Full text | PDF | PubMed

38.

Research   Open Access Highly Accessed

Predicting on-going hemorrhage and transfusion requirement after severe trauma: a validation of six scoring systems and algorithms on the TraumaRegister DGU®

Thomas Brockamp, Ulrike Nienaber, Manuel Mutschler, Arasch Wafaisade, Sigune Peiniger, Rolf Lefering, Bertil Bouillon, Marc Maegele, Critical Care 2012, 16:R129 (20 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

Study protocol   Open Access Highly Accessed

The randomized shortened dental arch study (RaSDA): design and protocol

Ralph G Luthardt, Birgit Marré, Achim Heinecke, Joachim Gerss, Hans Aggstaller, Eckhard Busche, Paul Dressler, Ingrid Gitt, Wolfgang Hannak, Sinsa Hartmann, Guido Heydecke, Florentine Jahn, Matthias Kern, Torsten Mundt, Peter Pospiech, Helmut Stark, Bernd Wöstmann, Michael H Walter Trials 2010, 11:15 (19 February 2010)

Abstract | Full text | PDF | PubMed

40.

Research article   Open Access Highly Accessed

Arthroscopy vs. MRI for a detailed assessment of cartilage disease in osteoarthritis: diagnostic value of MRI in clinical practice

Lars V von Engelhardt, Matthias Lahner, André Klussmann, Bertil Bouillon, Andreas Dàvid, Patrick Haage, Thomas K Lichtinger BMC Musculoskeletal Disorders 2010, 11:75 (20 April 2010)

Abstract | Full text | PDF | PubMed

41.

Research article   Open Access Highly Accessed

Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism

Melanie J Voss, Mischa F Möller, Desmond G Powe, Bernd Niggemann, Kurt S Zänker, Frank Entschladen BMC Cancer 2011, 11:158 (2 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

42.

Research   Open Access Highly Accessed

Reappraising the concept of massive transfusion in trauma

Simon J Stanworth, Timothy P Morris, Christine Gaarder, J Carel Goslings, Marc Maegele, Mitchell J Cohen, Thomas C König, Ross A Davenport, Jean-Francois Pittet, Pär I Johansson, Shubha Allard, Tony Johnson, Karim Brohi Critical Care 2010, 14:R239 (30 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

43.

Research   Open Access Highly Accessed

FIBTEM provides early prediction of massive transfusion in trauma

Herbert Schöchl, Bryan Cotton, Kenji Inaba, Ulrike Nienaber, Henrik Fischer, Wolfgang Voelckel, Cristina Solomon Critical Care 2011, 15:R265 (11 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

Research   Open Access Highly Accessed

Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury

Sigune Peiniger, Ulrike Nienaber, Rolf Lefering, Maximilian Braun, Arasch Wafaisade, Sebastian Wutzler, Matthew Borgmann, Philip C Spinella, Marc Maegele, Critical Care 2011, 15:R68 (22 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

45.

Research   Open Access Highly Accessed

Acute management and outcome of multiple trauma patients with pelvic disruptions

Markus Burkhardt, Ulrike Nienaber, Antonius Pizanis, Marc Maegele, Ulf Culemann, Bertil Bouillon, Sascha Flohé, Tim Pohlemann, Thomas Paffrath, Critical Care 2012, 16:R163 (22 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Low volume resuscitation does not yet seem to be accepted practice in the management of multiple trauma patients with pelvic disruption, despite initial massive fluid resuscitation being associated with worse outcomes.

46.

Research   Open Access Highly Accessed

Cardiopulmonary resuscitation traumatic cardiac arrest - there are survivors. An analysis of two national emergency registries

Jan-Thorsten Gräsner, Jan Wnent, Stephan Seewald, Patrick Meybohm, Matthias Fischer, Thomas Paffrath, Arasch Wafaisade, Berthold Bein, Rolf Lefering, Critical Care 2011, 15:R276 (22 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

47.

Research article   Open Access Highly Accessed

Individual and occupational risk factors for knee osteoarthritis: results of a case-control study in Germany

André Klussmann, Hansjürgen Gebhardt, Matthias Nübling, Falk Liebers, Emilio Quirós Perea, Wolfgang Cordier, Lars V von Engelhardt, Markus Schubert, Andreas Dávid, Bertil Bouillon, Monika A Rieger Arthritis Research & Therapy 2010, 12:R88 (14 May 2010)

Abstract | Full text | PDF | PubMed

48.

Research   Open Access Highly Accessed

Choice of hospital after out-of-hospital cardiac arrest - a decision with far-reaching consequences: a study in a large German city

Jan Wnent, Stephan Seewald, Matthias Heringlake, Hans Lemke, Kirk Brauer, Rolf Lefering, Matthias Fischer, Tanja Jantzen, Berthold Bein, Martin Messelken, Jan-Thorsten Gräsner Critical Care 2012, 16:R164 (12 September 2012)

Abstract | Full text | PDF | PubMed

49.

Research article   Open Access

Understanding, comprehensibility and acceptance of an evidence-based consumer information brochure on fall prevention in old age: a focus group study

Sabine Lins, Andrea Icks, Gabriele Meyer BMC Geriatrics 2011, 11:26 (20 May 2011)

Abstract | Full text | PDF | PubMed | 1 comment

50.

Research article   Open Access

Effect of pH of amine fluoride containing toothpastes on enamel remineralization in vitro

Wolfgang H Arnold, Anabel Haase, Julia Hacklaender, Zeno Gintner, Jolan Bánóczy, Peter Gaengler BMC Oral Health 2007, 7:14 (17 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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