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101.

Study protocol   Open Access Highly Accessed

Pancreatitis of biliary origin, optimal timing of cholecystectomy (PONCHO trial): study protocol for a randomized controlled trial

Stefan A Bouwense, Marc G Besselink, Sandra van Brunschot, Olaf J Bakker, Hjalmar C van Santvoort, Nicolien J Schepers, Marja A Boermeester, Thomas L Bollen, Koop Bosscha, Menno A Brink, Marco J Bruno, Esther C Consten, Cornelis H Dejong, Peter van Duijvendijk, Casper H van Eijck, Jos J Gerritsen, Harry van Goor, Joos Heisterkamp, Ignace H de Hingh, Philip M Kruyt, I Molenaar, Vincent B Nieuwenhuijs, Camiel Rosman, Alexander F Schaapherder, Joris J Scheepers, Marcel BW Spanier, Robin Timmer, Bas L Weusten, Ben J Witteman, Bert van Ramshorst, Hein G Gooszen, Djamila Boerma, et al. Trials 2012, 13:225 (26 November 2012)

Abstract | Full text | PDF | PubMed

102.

Research   Open Access

Specific combination of compound heterozygous mutations in 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency

Hugh J McMillan, Thea Worthylake, Jeremy Schwartzentruber, Chloe C Gottlieb, Sarah E Lawrence, Alex MacKenzie, Chandree L Beaulieu, Petra A W Mooyer, Ronald J A Wanders, Jacek Majewski, Dennis E Bulman, Michael T Geraghty, Sacha Ferdinandusse, Kym M Boycott Orphanet Journal of Rare Diseases 2012, 7:90 (22 November 2012)

Abstract | Full text | PDF | PubMed

103.

Meeting abstract   Open Access

Speeding up research with the Semantic Web

Marco Roos, Erik A Schultes, Barend Mons Orphanet Journal of Rare Diseases 2012, 7(Suppl 2):A11 (22 November 2012)

Full text | PDF

104.

Commentary   Subscription

Glycemic variability is complex - is glucose complexity variable?

Roosmarijn TM van Hooijdonk, Ameen Abu-Hanna, Marcus J Schultz Critical Care 2012, 16:178 (21 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

105.

Review   Subscription Highly Accessed

Clinical review: Circulatory shock - an update: a tribute to Professor Max Harry Weil

Jean-Louis Vincent, Can Ince, Jan Bakker Critical Care 2012, 16:239 (20 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

106.

Research article   Open Access

Home-based HIV counseling and testing: Client experiences and perceptions in Eastern Uganda

David Kyaddondo, Rhoda K Wanyenze, John Kinsman, Anita Hardon BMC Public Health 2012, 12:966 (12 November 2012)

Abstract | Full text | PDF | PubMed

107.

Research   Open Access

Clinical features and predictors for disease natural progression in adults with Pompe disease: a nationwide prospective observational study

Nadine AME van der Beek, Juna M de Vries, Marloes LC Hagemans, Wim CJ Hop, Marian A Kroos, John HJ Wokke, Marianne de Visser, Baziel GM van Engelen, Jan BM Kuks, Anneke J van der Kooi, Nicolette C Notermans, Karin G Faber, Jan JGM Verschuuren, Arnold JJ Reuser, Ans T van der Ploeg, Pieter A van Doorn Orphanet Journal of Rare Diseases 2012, 7:88 (12 November 2012)

Abstract | Full text | PDF | PubMed

108.

Study protocol   Open Access

Individual differences in the efficacy of a short theory of mind intervention for children with autism spectrum disorder: a randomized controlled trial

Elske Hoddenbach, Hans M Koot, Pamela Clifford, Carolien Gevers, Cassandra Clauser, Frits Boer, Sander Begeer Trials 2012, 13:206 (9 November 2012)

Abstract | Full text | PDF | PubMed

109.

Study protocol   Open Access

The Diabetes Pearl: Diabetes biobanking in The Netherlands

Esther van’t Riet, Miranda T Schram, Evertine J Abbink, Wanda M Admiraal, Marja W Dijk-Schaap, Frits Holleman, Giel Nijpels, Behiye Özcan, Hanno Pijl, Nicolaas C Schaper, Eric JG Sijbrands, Bianca Silvius, Cees J Tack, Harold W de Valk, Bruce HR Wolffenbuttel, Coen DA Stehouwer, Jacqueline M Dekker BMC Public Health 2012, 12:949 (6 November 2012)

Abstract | Full text | PDF | PubMed

110.

Review   Open Access Highly Accessed

The biased nucleotide composition of the HIV genome: a constant factor in a highly variable virus

Antoinette C van der Kuyl, Ben Berkhout Retrovirology 2012, 9:92 (6 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This review discuss all aspects of the lentiviral genome composition, both of the RNA and of its derived double-stranded DNA genome, with a focus on HIV-1, the nucleotide composition over time, the effects of artificially humanized codons as well as contributions of immune system pressure on HIV nucleotide bias.

111.

Original investigation   Open Access

Association between body size and blood pressure in children from different ethnic origins

Marieke LA de Hoog, Manon van Eijsden, Karien Stronks, Reinoud JBJ Gemke, Tanja GM Vrijkotte Cardiovascular Diabetology 2012, 11:136 (5 November 2012)

Abstract | Full text | PDF | PubMed

112.

Position article and guidelines   Open Access Highly Accessed

Research needs in allergy: an EAACI position paper, in collaboration with EFA

Nikolaos G Papadopoulos, Ioana Agache, Sevim Bavbek, Beatrice M Bilo, Fulvio Braido, Victoria Cardona, Adnan Custovic, Jan deMonchy, Pascal Demoly, Philippe Eigenmann, Jacques Gayraud, Clive Grattan, Enrico Heffler, Peter W Hellings, Marek Jutel, Edward Knol, Jan Lötvall, Antonella Muraro, Lars K Poulsen, Graham Roberts, Peter Schmid-Grendelmeier, Chrysanthi Skevaki, Massimo Triggiani, Ronald vanRee, Thomas Werfel, Breda Flood, Susanna Palkonen, Roberta Savli, Pia Allegri, Isabella Annesi-Maesano et al. Clinical and Translational Allergy 2012, 2:21 (2 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

113.

Review   Open Access

CMV and Immunosenescence: from basics to clinics

Rafael Solana, Raquel Tarazona, Allison E Aiello, Arne N Akbar, Victor Appay, Mark Beswick, Jos A Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein, Ann Hill, Mikko Hurme, Florian Kern, Anis Larbi, Miguel López-Botet, Andrea B Maier, Janet E McElhaney, Paul Moss, Elissaveta Naumova, Janko Nikolich-Zugich, Alejandra Pera, Jerrald L Rector, Natalie Riddell, Beatriz Sanchez-Correa, Paolo Sansoni, Delphine Sauce, Rene van Lier, George C Wang, Mark R Wills, Maciej Zieliński, Graham Pawelec et al. Immunity & Ageing 2012, 9:23 (31 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

114.

Research   Open Access

Medical-grade honey does not reduce skin colonization at central venous catheter-insertion sites of critically ill patients: a randomized controlled trial

Paulus H Kwakman, Marcella C Müller, Jan M Binnekade, Johannes P van den Akker, Corianne A de Borgie, Marcus J Schultz, Sebastian A Zaat Critical Care 2012, 16:R214 (30 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

115.

Review   Open Access

The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited: natural history, genetics, treatment and future perspectives

Annet M Bosch, Kevin Stroek, Nico G Abeling, Hans R Waterham, Lodewijk IJlst, Ronald JA Wanders Orphanet Journal of Rare Diseases 2012, 7:83 (29 October 2012)

Abstract | Full text | PDF | PubMed

116.

Research article   Open Access Highly Accessed

Socioeconomic inequalities in risk factors for non communicable diseases in low-income and middle-income countries: results from the World Health Survey

Ahmad Hosseinpoor, Nicole Bergen, Anton Kunst, Sam Harper, Regina Guthold, Dag Rekve, Edouard d'Espaignet, Nirmala Naidoo, Somnath Chatterji BMC Public Health 2012, 12:912 (28 October 2012)

Abstract | Full text | PDF | PubMed

117.

Research   Open Access Highly Accessed

A comparison of RIFLE with and without urine output criteria for acute kidney injury in critically ill patients

Kama A Wlodzimirow, Ameen Abu-Hanna, Mathilde Slabbekoorn, Robert AFM Chamuleau, Marcus J Schultz, Catherine SC Bouman Critical Care 2012, 16:R200 (18 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

118.

Research article   Open Access Highly Accessed

A systematic review with attempted network meta-analysis of asthma therapy recommended for five to eighteen year olds in GINA steps three and four

Lonneke B van der Mark, PH Edo Lyklema, Ronald B Geskus, Jacob Mohrs, Patrick JE Bindels, Wim MC van Aalderen, Gerben ter Riet BMC Pulmonary Medicine 2012, 12:63 (15 October 2012)

Abstract | Full text | PDF | PubMed

119.

Research   Open Access

Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study

Glenn Hernandez, Tomas Regueira, Alejandro Bruhn, Ricardo Castro, Maximiliano Rovegno, Andrea Fuentealba, Enrique Veas, Dolores Berrutti, Jorge Florez, Eduardo Kattan, Celeste Martin, Can Ince Annals of Intensive Care 2012, 2:44 (15 October 2012)

Abstract | Full text | PDF | PubMed

120.

Research article   Open Access Highly Accessed

Musculoskeletal disorders among construction workers: a one-year follow-up study

Julitta S Boschman, Henk F van der Molen, Judith K Sluiter, Monique HW Frings-Dresen BMC Musculoskeletal Disorders 2012, 13:196 (13 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

121.

Study protocol   Open Access

Comparison of the effectiveness of trauma-focused cognitive behavioral therapy and paroxetine treatment in PTSD patients: Design of a randomized controlled trial

A Polak, Anke B Witteveen, Rogier S Visser, Brent C Opmeer, Nienke Vulink, Martijn Figee, Damiaan Denys, Miranda Olff BMC Psychiatry 2012, 12:166 (9 October 2012)

Abstract | Full text | PDF | PubMed

122.

Technical Note   Open Access

Spatial gene expression quantification: a tool for analysis of in situ hybridizations in sea anemone Nematostella vectensis

Daniel Botman, Jaap A Kaandorp BMC Research Notes 2012, 5:555 (5 October 2012)

Abstract | Full text | PDF | PubMed

123.

Research   Open Access

Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'

Inge de Milliano, Merit M Tabbers, Joris A van der Post, Marc A Benninga Nutrition Journal 2012, 11:80 (4 October 2012)

Abstract | Full text | PDF | PubMed

124.

Research   Open Access

Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening

Liesbeth van der Sluijs Veer, Marlies JE Kempers, Heleen Maurice-Stam, Bob F Last, Tom Vulsma, Martha A Grootenhuis Child and Adolescent Psychiatry and Mental Health 2012, 6:32 (3 October 2012)

Abstract | Full text | PDF | PubMed

125.

Study protocol   Open Access Highly Accessed

Breast density as indicator for the use of mammography or MRI to screen women with familial risk for breast cancer (FaMRIsc): a multicentre randomized controlled trial

Sepideh Saadatmand, Emiel J T Rutgers, RobAEM Tollenaar, Hermien M Zonderland, MargreetGEM Ausems, KristienBMI Keymeulen, Margreet S Schlooz-Vries, Linetta B Koppert, Eveline A M Heijnsdijk, Caroline Seynaeve, Cees Verhoef, Jan C Oosterwijk, Inge-Marie Obdeijn, Harry J de Koning, Madeleine M A Tilanus-Linthorst BMC Cancer 2012, 12:440 (2 October 2012)

Abstract | Full text | PDF | PubMed

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