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1.

Research article   Open Access Highly Accessed

Polyploidization increases meiotic recombination frequency in Arabidopsis

Ales Pecinka, Wei Fang, Marc Rehmsmeier, Avraham A Levy, Ortrun Mittelsten Scheid BMC Biology 2011, 9:24 (21 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In evolutionary terms, polyploidy has both costs and benefits for an organism. Help in quantifying these is given by an elegant assay involving fluorescent Arabidopsis seeds, which shows that polyploids have an elevated rate of meiotic recombination.

2.

Research   Open Access Highly Accessed

Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

Hubert Hackl, Thomas Burkard, Alexander Sturn, Renee Rubio, Alexander Schleiffer, Sun Tian, John Quackenbush, Frank Eisenhaber, Zlatko Trajanoski Genome Biology 2005, 6:R108 (19 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

In-depth bioinformatics analyses of expressed sequence tags found to be differentially expressed during differentiation of 3T3-L1 pre-adipocyte cells were combined with de novo functional annotation and mapping onto known pathways to generate a molecular atlas of fat-cell development.

3.

Software   Open Access

MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins

Sebastian Maurer-Stroh, Masaki Gouda, Maria Novatchkova, Alexander Schleiffer, Georg Schneider, Fernanda L Sirota, Michael Wildpaner, Nobuhiro Hayashi, Frank Eisenhaber Genome Biology 2004, 5:R21 (13 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

MYRbase is a database of glycine myristoylation in eukaryotes. This study shows that the functional spectrum of myristoylated proteins has been underestimated and five membrane-attachment factors that occur frequently with myristoylation have been classified.

4.

Software   Open Access

Refinement and prediction of protein prenylation motifs

Sebastian Maurer-Stroh, Frank Eisenhaber Genome Biology 2005, 6:R55 (27 May 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Three prenylation motif predictors are presented that allow discrimination between proteins that are unique substrates of farnesyltransferase (FT) and those that can be alternatively processed by geranylgeranyltransferase I (GGT1).

5.

Methodology article   Open Access Highly Accessed

Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo

Wolfgang Benetka, Manfred Koranda, Sebastian Maurer-Stroh, Fritz Pittner, Frank Eisenhaber BMC Biochemistry 2006, 7:6 (28 February 2006)

Abstract | Full text | PDF | PubMed

6.

Research article   Open Access Highly Accessed

Large-scale mapping of mutations affecting zebrafish development

Robert Geisler, Gerd-Jörg Rauch, Silke Geiger-Rudolph, Andrea Albrecht, Frauke van Bebber, Andrea Berger, Elisabeth Busch-Nentwich, Ralf Dahm, Marcus PS Dekens, Christopher Dooley, Alexandra F Elli, Ines Gehring, Horst Geiger, Maria Geisler, Stefanie Glaser, Scott Holley, Matthias Huber, Andy Kerr, Anette Kirn, Martina Knirsch, Martina Konantz, Axel M Küchler, Florian Maderspacher, Stephan C Neuhauss, Teresa Nicolson, Elke A Ober, Elke Praeg, Russell Ray, Brit Rentzsch, Jens M Rick et al. BMC Genomics 2007, 8:11 (9 January 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Protein family review   Free

Protein prenyltransferases

Sebastian Maurer-Stroh, Stefan Washietl, Frank Eisenhaber Genome Biology 2003, 4:212 (1 April 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Three different protein prenyltransferases catalyze the attachment of prenyl lipid anchors to a variety of eukaryotic proteins. Farnesyltransferase-inhibitor drugs have been developed as anti-cancer agents and may also be able to treat several other diseases.

8.

Protein family review   Free Highly Accessed

The ring between ring fingers (RBR) protein family

Birgit Eisenhaber, Nina Chumak, Frank Eisenhaber, Marie-Theres Hauser Genome Biology 2007, 8:209 (15 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An overview of the large and functionally diverse RBR protein family that mediates protein-protein interactions of various kinds in development and disease.

9.

Software   Open Access

A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database

José L Jiménez, Björn Hegemann, James RA Hutchins, Jan-Michael Peters, Richard Durbin Genome Biology 2007, 8:R90 (23 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

mtcPTM is a new database of phosphorylated protein sequences and atomic models. Analysis of the phosphosites in mtcPTM showed that phosphorylation sites are found in a highly heterogeneous range of structural and sequence contexts.

10.

Review   Free Highly Accessed

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease

Rainer Zenz, Robert Eferl, Clemens Scheinecker, Kurt Redlich, Josef Smolen, Helia B Schonthaler, Lukas Kenner, Erwin Tschachler, Erwin F Wagner Arthritis Research & Therapy 2008, 10:201 (18 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

Methodology article   Open Access Highly Accessed

From an electrophoretic mobility shift assay to isolated transcription factors: a fast genomic-proteomic approach

Astrid R Mach-Aigner, Karin Grosstessner-Hain, Marcio J Poças-Fonseca, Karl Mechtler, Robert L Mach BMC Genomics 2010, 11:644 (18 November 2010)

Abstract | Full text | PDF | PubMed

12.

Research   Open Access

Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors

Sara Molatore, Eva Kiermaier, Christian B Jung, Misu Lee, Elke Pulz, Heinz Höfler, Michael J Atkinson, Natalia S Pellegata Molecular Cancer 2010, 9:116 (21 May 2010)

Abstract | Full text | PDF | PubMed

13.

Research   Open Access

Patterns of perceptions of workplace violence in the Portuguese health care sector

Paulo Ferrinho, André Biscaia, Inês Fronteira, Isabel Craveiro, Ana Antunes, Claudia Conceição, Isabel Flores, Osvaldo Santos Human Resources for Health 2003, 1:11 (7 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Research article   Open Access Highly Accessed

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation

Maxime Bouchard, Dominique de Caprona, Meinrad Busslinger, Pinxian Xu, Bernd Fritzsch BMC Developmental Biology 2010, 10:89 (20 August 2010)

Abstract | Full text | PDF | PubMed

15.

Research   Open Access

Reducing the haystack to find the needle: improved protein identification after fast elimination of non-interpretable peptide MS/MS spectra and noise reduction

Nedim Mujezinovic, Georg Schneider, Michael Wildpaner, Karl Mechtler, Frank Eisenhaber BMC Genomics 2010, 11(Suppl 1):S13 (10 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Technical Note   Open Access Highly Accessed

Comparison of different methods for preparation and characterization of total RNA from cartilage samples to uncover osteoarthritis in vivo

Anke Ruettger, Steffi Neumann, Bernd Wiederanders, René Huber BMC Research Notes 2010, 3:7 (18 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

Research   Open Access

Direct cooling of the catheter tip increases safety for CMR-guided electrophysiological procedures

Theresa Reiter, Daniel Gensler, Oliver Ritter, Ingo Weiss, Wolfgang Geistert, Ralf Kaufmann, Sabine Hoffmeister, Michael T Friedrich, Stefan Wintzheimer, Markus Düring, Peter Nordbeck, Peter M Jakob, Mark E Ladd, Harald H Quick, Wolfgang R Bauer Journal of Cardiovascular Magnetic Resonance 2012, 14:12 (1 February 2012)

Abstract | Full text | PDF | PubMed

18.

Methodology article   Open Access

Establishment of a Cre/loxP recombination system for N-terminal epitope tagging of genes in Tetrahymena

Clara Busch, Alexander Vogt, Kazufumi Mochizuki BMC Microbiology 2010, 10:191 (13 July 2010)

Abstract | Full text | PDF | PubMed

19.

Research article   Open Access

Proteins with two SUMO-like domains in chromatin-associated complexes: The RENi (Rad60-Esc2-NIP45) family

Maria Novatchkova, Andreas Bachmair, Birgit Eisenhaber, Frank Eisenhaber BMC Bioinformatics 2005, 6:22 (7 February 2005)

Abstract | Full text | PDF | PubMed

20.

Research article   Open Access

Dynamic localisation of Ran GTPase during the cell cycle

James RA Hutchins, William J Moore, Paul R Clarke BMC Cell Biology 2009, 10:66 (18 September 2009)

Abstract | Full text | PDF | PubMed

21.

Methodology article   Open Access

Application of a sensitive collection heuristic for very large protein families: Evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases

Georg Schneider, Georg Neuberger, Michael Wildpaner, Sun Tian, Igor Berezovsky, Frank Eisenhaber BMC Bioinformatics 2006, 7:164 (21 March 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

Research article   Open Access

Nuclear distribution and chromatin association of DNA polymerase α-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast

Xiaowen Yang, Juraj Gregan, Karola Lindner, Hedi Young, Stephen E Kearsey BMC Molecular Biology 2005, 6:13 (7 June 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

Research article   Open Access

Comparative analysis of sequence features involved in the recognition of tandem splice sites

Ralf Bortfeldt, Stefanie Schindler, Karol Szafranski, Stefan Schuster, Dirk Holste BMC Genomics 2008, 9:202 (30 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Research article   Open Access

Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenoviruses

Stefan Washietl, Frank Eisenhaber BMC Bioinformatics 2003, 4:55 (7 November 2003)

Abstract | Full text | PDF | PubMed

25.

Poster presentation   Open Access

Induction of HIV mucosal immunity at distal sites after encapsulation of NOD1 and NOD2 ligands in biodegradable nanocarriers

V Pavot, N Rochereau, V Lahaye, C Genin, E Perouzel, T Lioux, C Primard, T Delair, S Paul, B Verrier Retrovirology 2012, 9(Suppl 2):P194 (13 September 2012)

Full text | PDF

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