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1.

Research article   Open Access Highly Accessed

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model

Bhupinder Virk, Gonçalo Correia, David P Dixon, Inna Feyst, Jie Jia, Nikolin Oberleitner, Zoe Briggs, Emily Hodge, Robert Edwards, John Ward, David Gems, David Weinkove BMC Biology 2012, 10:67 (31 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

David Weinkove and colleagues report an accidental discovery in C. elegans that has led them to a series of studies implicating folate in excess of needs in limiting lifespan, with interesting hints from the effects of sulfonamide drugs that the same may apply to mammals.

2.

Protocol   Open Access Highly Accessed

Tackling inequalities in obesity: a protocol for a systematic review of the effectiveness of public health interventions at reducing socioeconomic inequalities in obesity amongst children

Clare L Bambra, Frances C Hillier, Helen J Moore, Carolyn D Summerbell Systematic Reviews 2012, 1:16 (23 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

Research article   Open Access Highly Accessed

Do students learn to be more conscientious at medical school?

Andrew T Chaytor, Jacqueline Spence, Ann Armstrong, John C McLachlan BMC Medical Education 2012, 12:54 (11 July 2012)

Abstract | Full text | PDF | PubMed

4.

Methodology   Open Access Highly Accessed

An improved method for preparing Agrobacterium cells that simplifies the Arabidopsis transformation protocol

Elke Logemann, Rainer P Birkenbihl, Bekir Ülker, Imre E Somssich Plant Methods 2006, 2:16 (24 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

Research article   Open Access Highly Accessed

Migration experiences, employment status and psychological distress among Somali immigrants: a mixed-method international study

Nasir Warfa, Sarah Curtis, Charles Watters, Ken Carswell, David Ingleby, Kamaldeep Bhui BMC Public Health 2012, 12:749 (7 September 2012)

Abstract | Full text | PDF | PubMed

6.

Study protocol   Open Access

UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial

Fiona F Craig, Kim S Thomas, Eleanor J Mitchell, Hywel C Williams, John Norrie, James M Mason, Anthony D Ormerod, Trials 2012, 13:51 (28 April 2012)

Abstract | Full text | PDF | PubMed

7.

Research   Open Access Highly Accessed

Larvicidal effects of a neem (Azadirachta indica) oil formulation on the malaria vector Anopheles gambiae

Fredros O Okumu, Bart GJ Knols, Ulrike Fillinger Malaria Journal 2007, 6:63 (22 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Neem oil has good larvicidal properties for mosquitoes and suppresses successful adult emergence at very low concentrations. Considering the wide distribution and availability of this tree and its products along the East African coast, this may prove a readily available and cheap alternative to conventional larvicides.

8.

Research article   Open Access Highly Accessed

Reconstructing the ups and downs of primate brain evolution: implications for adaptive hypotheses and Homo floresiensis

Stephen H Montgomery, Isabella Capellini, Robert A Barton, Nicholas I Mundy BMC Biology 2010, 8:9 (27 January 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Brain expansion began early in primate evolution and has occurred in all major clades, however in some lineages this trend has been reversed, accomodating plausible scenarios for the evolution of the small-brained hominin, Homo floresiensis.

9.

Research   Open Access

What helps and hinders midwives in engaging with pregnant women about stopping smoking? A cross-sectional survey of perceived implementation difficulties among midwives in the North East of England

Jane Beenstock, Falko F Sniehotta, Martin White, Ruth Bell, Eugene MG Milne, Vera Araujo-Soares Implementation Science 2012, 7:36 (24 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

Methodology   Open Access Highly Accessed

A tool box for operational mosquito larval control: preliminary results and early lessons from the Urban Malaria Control Programme in Dar es Salaam, Tanzania

Ulrike Fillinger, Khadija Kannady, George William, Michael J Vanek, Stefan Dongus, Dickson Nyika, Yvonne Geissbühler, Prosper P Chaki, Nico J Govella, Evan M Mathenge, Burton H Singer, Hassan Mshinda, Steven W Lindsay, Marcel Tanner, Deo Mtasiwa, Marcia C de Castro, Gerry F Killeen Malaria Journal 2008, 7:20 (25 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A programme which delegates responsibility for routine mosquito control and surveillance to modestly-paid community members. This pilot study addresses some of the important issues of larviciding in an urban environment.

11.

Protein family review   Free Highly Accessed

Plant glutathione transferases

David P Dixon, Adrian Lapthorn, Robert Edwards Genome Biology 2002, 3:reviews3004-reviews3004.10 (26 February 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The soluble glutathione transferases (GSTs) are a large, conserved family of proteins that use the tripeptide glutathione as a cosubstrate or coenzyme. They are predominantly expressed in the cytosol and have a range of catalytic and non-catalytic functions, including detoxification of herbicides and protection from oxidative stress, and have been implicated in other cellular processes.

12.

Study protocol   Open Access

Psycho-education with problem solving (PEPS) therapy for adults with personality disorder: A pragmatic multi-site community-based randomised clinical trial

Mary McMurran, Mike J Crawford, Joseph G Reilly, Paul McCrone, Paul Moran, Hywel Williams, Clive E Adams, Conor Duggan, Juan Delport, Diane Whitham, Florence Day Trials 2011, 12:198 (24 August 2011)

Abstract | Full text | PDF | PubMed

13.

Methodology   Open Access

Participatory mapping of target areas to enable operational larval source management to suppress malaria vector mosquitoes in Dar es Salaam, Tanzania

Stefan Dongus, Dickson Nyika, Khadija Kannady, Deo Mtasiwa, Hassan Mshinda, Ulrike Fillinger, Axel W Drescher, Marcel Tanner, Marcia C Castro, Gerry F Killeen International Journal of Health Geographics 2007, 6:37 (4 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Research article   Open Access

Forced residential mobility and social support: impacts on psychiatric disorders among Somali migrants

Kamaldeep Bhui, Salaad Mohamud, Nasir Warfa, Sarah Curtis, Stephen Stansfeld, Tom Craig BMC International Health and Human Rights 2012, 12:4 (17 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Residential instability among Somali war refugees living in London is associated with an increased risk of developing psychiatric disorders, though migrants with a stronger social support network may be more resilient.

15.

Review   Open Access

Reinterpretation of evidence advanced for neo-oogenesis in mammals, in terms of a finite oocyte reserve

Elena Notarianni Journal of Ovarian Research 2011, 4:1 (6 January 2011)

Abstract | Full text | PDF | PubMed

16.

Research   Open Access

Challenges to conservation: land use change and local participation in the Al Reem Biosphere Reserve, West Qatar

Paul Sillitoe, Ali A Alshawi, Abdul K Al-Amir Hassan Journal of Ethnobiology and Ethnomedicine 2010, 6:28 (21 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

Research   Open Access Highly Accessed

Identifying the most productive breeding sites for malaria mosquitoes in The Gambia

Ulrike Fillinger, Heleen Sombroek, Silas Majambere, Emiel van Loon, Willem Takken, Steven W Lindsay Malaria Journal 2009, 8:62 (10 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A paper on an important aspect of malaria vector ecology, with relevance to control. The results indicate that anti-larval interventions in this area of The Gambia cannot be targeted in space or time during the rainy season.

18.

Methodology article   Open Access

A specialized ODE integrator for the efficient computation of parameter sensitivities

Pedro Gonnet, Sotiris Dimopoulos, Lukas Widmer, Jörg Stelling BMC Systems Biology 2012, 6:46 (20 May 2012)

Abstract | Full text | PDF | PubMed

19.

Research   Open Access Highly Accessed

Modelling the relationship between obesity and mental health in children and adolescents: findings from the Health Survey for England 2007

Paul A Tiffin, Bronia Arnott, Helen J Moore, Carolyn D Summerbell Child and Adolescent Psychiatry and Mental Health 2011, 5:31 (7 October 2011)

Abstract | Full text | PDF | PubMed

20.

Research article   Open Access Highly Accessed

Parasite resistance and the adaptive significance of sleep

Brian T Preston, Isabella Capellini, Patrick McNamara, Robert A Barton, Charles L Nunn BMC Evolutionary Biology 2009, 9:7 (9 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Mammalian species that sleep for longer periods have a better immune system and fewer parasitic infections, suggesting that sleep has an underappreciated role in disease resistance.

21.

Research   Open Access Highly Accessed

An exploratory study of community factors relevant for participatory malaria control on Rusinga Island, western Kenya

Pamela Opiyo, W Richard Mukabana, Ibrahim Kiche, Evan Mathenge, Gerry F Killeen, Ulrike Fillinger Malaria Journal 2007, 6:48 (24 April 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Evidence-based education interventions, utilizing participatory tools, need to be applied at grassroots level, to look at traditional beliefs and enable understanding of causal connections between mosquito ecology, parasite transmission and the diagnosis, treatment and prevention of disease

22.

Research article   Open Access

Anatomy teaching with portable ultrasound to medical students

Meenakshi Swamy, Roger F Searle BMC Medical Education 2012, 12:99 (22 October 2012)

Abstract | Full text | PDF | PubMed

23.

Research   Open Access Highly Accessed

Microbial larvicides for malaria control in The Gambia

Silas Majambere, Steven W Lindsay, Clare Green, Balla Kandeh, Ulrike Fillinger Malaria Journal 2007, 6:76 (7 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Environmentally safe microbial larvicides can significantly reduce larval abundance in the natural habitats of The Gambia and could be a useful tool for inclusion in an integrated vector management programme.

24.

Research article   Open Access

Role of SimMan in teaching clinical skills to preclinical medical students

Meenakshi Swamy, Thomas C Bloomfield, Robert H Thomas, Harnaik Singh, Roger F Searle BMC Medical Education 2013, 13:20 (10 February 2013)

Abstract | Full text | PDF | PubMed

25.

Correspondence   Open Access

Evidence-based development of school-based and family-involved prevention of overweight across Europe: The ENERGY-project's design and conceptual framework

Johannes Brug, Saskia J te Velde, Mai JM Chinapaw, Elling Bere, Ilse de Bourdeaudhuij, Helen Moore, Lea Maes, Jorgen Jensen, Yannis Manios, Nanna Lien, Knut Klepp, Tim Lobstein, Marloes Martens, Jo Salmon, Amika S Singh BMC Public Health 2010, 10:276 (25 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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