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76.

Methodology article   Open Access Highly Accessed

Whole genome sequencing analysis of Plasmodium vivax using whole genome capture

A Bright, Ryan Tewhey, Shira Abeles, Raul Chuquiyauri, Alejandro Llanos-Cuentas, Marcelo U Ferreira, Nicholas J Schork, Joseph M Vinetz, Elizabeth A Winzeler BMC Genomics 2012, 13:262 (21 June 2012)

Abstract | Full text | PDF | PubMed

77.

Original clinical investigation   Open Access

Comparison of 3,000 and 5,000 IU aXa/day certoparin in the prevention of deep-vein thrombosis after total hip replacement

Peter Bramlage, Hans-Christoph Michaelis, Nima Melzer Thrombosis Journal 2012, 10:10 (19 June 2012)

Abstract | Full text | PDF | PubMed

78.

Original research   Open Access

PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues

Simone Däpp, Cristina Müller, Elisa Garayoa, Peter Bläuenstein, Veronique Maes, Luc Brans, Dirk A Tourwé, Roger Schibli EJNMMI Research 2012, 2:24 (9 June 2012)

Abstract | Full text | PDF | PubMed

79.

Comment   Open Access

Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science

David J Glass, Bruce M Spiegelman Skeletal Muscle 2012, 2:11 (7 June 2012)

Abstract | Full text | PDF | PubMed

80.

Research article   Open Access

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

Suleiman A Khan, Ali Faisal, John Mpindi, Juuso A Parkkinen, Tuomo Kalliokoski, Antti Poso, Olli P Kallioniemi, Krister Wennerberg, Samuel Kaski BMC Bioinformatics 2012, 13:112 (30 May 2012)

Abstract | Full text | PDF | PubMed

81.

Research article   Open Access

Medical student attitudes towards family medicine in Spain: a statewide analysis

Amando Zurro, Josep Villa, Antonio Hijar, Xavier Tuduri, Ángel Puime, Pablo Alonso-Coello, BMC Family Practice 2012, 13:47 (29 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

82.

Methodology article   Open Access

Natural product-likeness score revisited: an open-source, open-data implementation

Kalai Vanii, Pablo Moreno, Andreas Truszkowski, Peter Ertl, Christoph Steinbeck BMC Bioinformatics 2012, 13:106 (20 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

83.

Research   Open Access

Determination of minimal transcriptional signatures of compounds for target prediction

Florian Nigsch, Janna Hutz, Ben Cornett, Douglas W Selinger, Gregory McAllister, Somnath Bandyopadhyay, Joseph Loureiro, Jeremy L Jenkins EURASIP Journal on Bioinformatics and Systems Biology 2012, 2012:2 (10 May 2012)

Abstract | Full text | PDF | PubMed

84.

Research article   Open Access

Acceptability – a neglected dimension of access to health care: findings from a study on childhood convulsions in rural Tanzania

Angel Dillip, Sandra Alba, Christopher Mshana, Manuel W Hetzel, Christian Lengeler, Iddy Mayumana, Alexander Schulze, Hassan Mshinda, Mitchell G Weiss, Brigit Obrist BMC Health Services Research 2012, 12:113 (9 May 2012)

Abstract | Full text | PDF | PubMed

85.

Review   Open Access Highly Accessed

A systematic review of the safety and efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria during pregnancy

Christine Manyando, Kassoum Kayentao, Umberto D’Alessandro, Henrietta U Okafor, Elizabeth Juma, Kamal Hamed Malaria Journal 2012, 11:141 (1 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

There is evidence to suggest that the pharmacokinetics of anti-malarial drugs may change in pregnancy, although the majority of studies report high cure rates and adequate tolerability. The paper reinforces the WHO recommendation to treat uncomplicated falciparum malaria with quinine plus clindamycin in early pregnancy and ACT in later pregnancy.

86.

Research   Open Access

Therapeutic efficacy of milbemycin oxime/praziquantel oral formulation (Milbemax®) against Thelazia callipaeda in naturally infested dogs and cats

Bruna Motta, Manuela Schnyder, Fabrizio Basano, Fabio Nägeli, Catherine Nägeli, Brigitte Schiessl, Egidio Mallia, Riccardo P Lia, Filipe Dantas-Torres, Domenico Otranto Parasites & Vectors 2012, 5:85 (27 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In a placebo controlled field study conducted with 56 dogs and 31cats from Thelazia callipaeda endemic areas of Switzerland and Italy the commercial formulation Milbemax (milbemycin oxime/praziquantel tablets) showed a high therapeutic efficacy in curing T. callipaeda infestations. Image: Eye of a cat from Basilicata (Italy) infested with several adult specimens of Thelazia callipaeda.

87.

Research   Open Access

The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases

Liz Hardaker, Parmjit Bahra, Benjamin de Billy, Mark Freeman, Natalia Kupfer, Daniel Wyss, Alexandre Trifilieff Respiratory Research 2012, 13:30 (4 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

88.

Research article   Open Access Highly Accessed

Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor

Aiying Wang, Charles Dorso, Lisa Kopcho, Gregory Locke, Robert Langish, Eric Harstad, Petia Shipkova, Jovita Marcinkeviciene, Lawrence Hamann, Mark S Kirby BMC Pharmacology 2012, 12:2 (4 April 2012)

Abstract | Full text | PDF | PubMed

89.

Research   Open Access Highly Accessed

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

Emmanouil Fokas, Michio Yoshimura, Remko Prevo, Geoff Higgins, Wolfgang Hackl, Sauveur-Michel Maira, Eric J Bernhard, W Gillies McKenna, Ruth J Muschel Radiation Oncology 2012, 7:48 (27 March 2012)

Abstract | Full text | PDF | PubMed

90.

Research article   Open Access Highly Accessed

A patient perspective of the impact of medication side effects on adherence: results of a cross-sectional nationwide survey of patients with schizophrenia

Marco DiBonaventura, Susan Gabriel, Leon Dupclay, Shaloo Gupta, Edward Kim BMC Psychiatry 2012, 12:20 (20 March 2012)

Abstract | Full text | PDF | PubMed

91.

Research article   Open Access Highly Accessed

The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Elisabetta Tabolacci, Filomena Pirozzi, Baltazar Gomez-Mancilla, Fabrizio Gasparini, Giovanni Neri BMC Medical Genetics 2012, 13:13 (7 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The beneficial effect of Fragile X syndrome (FXS) drug AFQ056 for patients with fully methylated FMR1 genes does not act through a secondary effects on FMR1 mRNA production or promoter methylation, in FXS lymphoblastoid cell lines.

92.

Research article   Open Access

Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis

Altan Ercan, Jing Cui, Melissa M Hazen, Franak Batliwalla, Louise Royle, Pauline M Rudd, Jonathan S Coblyn, Nancy Shadick, Michael E Weinblatt, Peter Gregersen, David M Lee, Peter A Nigrovic Arthritis Research & Therapy 2012, 14:R43 (5 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

93.

Research   Open Access

Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices

Pedro A Ruiz, Gabor Jarai Fibrogenesis & Tissue Repair 2012, 5:3 (15 February 2012)

Abstract | Full text | PDF | PubMed

94.

Research   Open Access

TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A

Anne Trendelenburg, Angelika Meyer, Carsten Jacobi, Jerome N Feige, David J Glass Skeletal Muscle 2012, 2:3 (7 February 2012)

Abstract | Full text | PDF | PubMed

95.

Research article   Open Access Highly Accessed

Relationship of orthopedic examination, goniometric measurements, and radiographic signs of degenerative joint disease in cats

B Duncan X Lascelles, Yaa-Hui Dong, Denis J Marcellin-Little, Andrea Thomson, Simon Wheeler, Maria Correa BMC Veterinary Research 2012, 8:10 (27 January 2012)

Abstract | Full text | PDF | PubMed

96.

Research article   Open Access Highly Accessed

Predicting the mechanism of phospholipidosis

Robert Lowe, Hamse Y Mussa, Florian Nigsch, Robert C Glen, John BO Mitchell Journal of Cheminformatics 2012, 4:2 (26 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary | Graphical abstract

An in silico approach was used to predict targets for phospholipidosis, a lysosomal disorder characterized by accumulation of phospholipids in tissues. By predicting targets for a database of compounds, they can be ranked by their potential to cause phospholipidosis

97.

Research   Open Access Highly Accessed

The new pLAI (lux regulon based auto-inducible) expression system for recombinant protein production in Escherichia coli

Salvatore Nocadello, Erwin Swennen Microbial Cell Factories 2012, 11:3 (5 January 2012)

Abstract | Full text | PDF | PubMed

98.

Editorial   Open Access Highly Accessed

Skeletal Muscle - one year on

David Glass, Kevin Campbell, Michael Rudnicki Skeletal Muscle 2012, 2:1 (5 January 2012)

Abstract | Full text | PDF | PubMed

99.

Research   Open Access Highly Accessed

Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: a pooled analysis

Paul W Jones, James F Donohue, Jerry Nedelman, Steve Pascoe, Gregory Pinault, Cheryl Lassen Respiratory Research 2011, 12:161 (29 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

100.

Research article   Open Access

Comparison of resource use by COPD patients on inhaled therapies with long-acting bronchodilators: a database study

Chris M Kozma, Andrew L Paris, Craig A Plauschinat, Terra Slaton, John I Mackowiak BMC Pulmonary Medicine 2011, 11:61 (22 December 2011)

Abstract | Full text | PDF | PubMed

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