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Work published with BioMed Central in the last 12 months by researchers at Novartis Group
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Research
Development and psychometric assessment of the COPD and Asthma Sleep Impact Scale (CASIS) Pokrzywinski RF, Meads DM, McKenna SP, Glendenning GA, Revicki DA Health and Quality of Life Outcomes 2009, 7 :98 (7 December 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research
Expression of complement system components during aging and amyloid deposition in APP transgenic mice Reichwald J, Danner S, Wiederhold KH, Staufenbiel M Journal of Neuroinflammation 2009, 6 :35 (17 November 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Software
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW, Su AI Genome Biology 2009, 10 :R130 (17 November 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Review
Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy Yuan RR, Kay A, Berg WJ, Lebwohl D Journal of Hematology & Oncology 2009, 2 :45 (27 October 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Poster presentation
P19-14. Recombinant alphavirus replicon particles as a platform to evaluate immunogenicity of early transmitted clade C virus envelopes Franti M, Nandi A, Smith L, Lilja A, Balsitis S, Dey A, Zambonelli C, Srivastava I, Barnett SW Retrovirology 2009, 6 (Suppl 3):P334 (22 October 2009) [Abstract ] [Full text ] [PDF ]
Poster presentation
P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers Moscoso CG, Kan E, Poon S, Sun Y, Martin L, Xing L, Green DJ, Lin F, Barnett S, Srivastava I, Cheng R Retrovirology 2009, 6 (Suppl 3):P343 (22 October 2009) [Abstract ] [Full text ] [PDF ]
Poster presentation
P04-25. Exposure of HIV-1 pseudovirus to soluble CD4 increases the breadth of neutralization with sera from macaques immunized with recombinant glycoproteins Davis D, Verschoor E, Mortier D, Fagrouch Z, Deuzing I, Burke B, Srivastava I, Kan E, Sun Y, Barnett S, Heeney J, Bogers W Retrovirology 2009, 6 (Suppl 3):P53 (22 October 2009) [Abstract ] [Full text ] [PDF ]
Poster presentation
P05-10. Sequential immunization with a subtype B HIV-1 envelope quasispecies elicits broader neutralization than vaccination with a single envelope clone Malherbe DC, Doria-Rose N, Misher L, Beckett T, Blay-Puryear W, Barnett S, Srivastava I, Richardson B, Stamatatos L, Haigwood NL Retrovirology 2009, 6 (Suppl 3):P86 (22 October 2009) [Abstract ] [Full text ] [PDF ]
Research article
Transcription factor site dependencies in human, mouse and rat genomes Tomovic A, Stadler M, Oakeley EJ BMC Bioinformatics 2009, 10 :339 (16 October 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Review
Understanding the pharmacokinetics of Coartem® Djimdé A, Lefèvre G Malaria Journal 2009, 8 (Suppl 1):S4 (12 October 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland Stoelzle T, Schwarb P, Trumpp A, Hynes NE BMC Biology 2009, 7 :63 (28 September 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Poster presentation
The first crystal structure of cyclic GMP-dependent protein kinase I Casteel DE, Smith-Nguyen EV, Sankaran B, Spraggon G, Hampton EN, Pilz RB, Taylor SS, Kim C BMC Pharmacology 2009, 9 (Suppl 1):P6 (11 August 2009) [Abstract ] [Full text ] [PDF ]
Research article
Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein Piao L, Li Y, Yang KJ, Park KA, Byun HS, Won M, Hong J, Kim JL, Kweon GR, Hur GM, Seok JH, Cho JY, Chun T, Hess D, Sack R, Maira SM, Brazil DP, Hemmings BA, Park J BMC Cell Biology 2009, 10 :53 (15 July 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Unfractionated heparin and enoxaparin reduce high-stretch ventilation augmented lung injury: a prospective, controlled animal experiment Li LF, Huang CC, Lin HC, Tsai YH, Quinn DA, Liao SK Critical Care 2009, 13 :R108 (6 July 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Socio-cultural factors explaining timely and appropriate use of health facilities for degedege in south-eastern Tanzania Dillip A, Hetzel MW, Gosoniu D, Kessy F, Lengeler C, Mayumana I, Mshana C, Mshinda H, Schulze A, Makemba A, Pfeiffer C, Weiss MG, Obrist B Malaria Journal 2009, 8 :144 (29 June 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancerLykkesfeldt AE, Henriksen KL, Rasmussen BB, Sasano H, Evans DB, Møller S, Ejlertsen B, Mouridsen HT BMC Cancer 2009, 9 :185 (16 June 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis Pollizzi K, Malinowska-Kolodziej I, Stumm M, Lane H, Kwiatkowski D Molecular Cancer 2009, 8 :38 (15 June 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions Ertl P, Schuffenhauer A Journal of Cheminformatics 2009, 1 :8 (10 June 2009) [Abstract ] [Full Text ] [PDF ]
Research
Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice Stowell NC, Seideman J, Raymond HA, Smalley KA, Lamb RJ, Egenolf DD, Bugelski PJ, Murray LA, Marsters PA, Bunting RA, Flavell RA, Alexopoulou L, San Mateo LR, Griswold DE, Sarisky RT, Mbow ML, Das AM Respiratory Research 2009, 10 :43 (1 June 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth Matsuda Y, Schlange T, Oakeley EJ, Boulay A, Hynes NE Breast Cancer Research 2009, 11 :R32 (27 May 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Effectiveness of different methods for delivering tailored nutrition education to low income, ethnically diverse adults Gans KM, Risica PM, Strolla LO, Fournier L, Kirtania U, Upegui D, Zhao J, George T, Acharyya S International Journal of Behavioral Nutrition and Physical Activity 2009, 6 :24 (5 May 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
Evaluation of the in vitro skin permeation of antiviral drugs from penciclovir 1% cream and acyclovir 5% cream used to treat herpes simplex virus infection Hasler-Nguyen N, Shelton D, Ponard G, Bader M, Schaffrik M, Mallefet P BMC Dermatology 2009, 9 :3 (2 April 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study Argiriadi MA, Sousa S, Banach D, Marcotte D, Xiang T, Tomlinson MJ, Demers M, Harris C, Kwak S, Hardman J, Pietras M, Quinn L, DiMauro J, Ni B, Mankovich J, Borhani DW, Talanian RV, Sadhukhan R BMC Structural Biology 2009, 9 :16 (18 March 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats Schweitzer A, Hasler-Nguyen N, Zijlstra J BMC Pharmacology 2009, 9 :5 (16 March 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia Laterre PF, Opal SM, Abraham E, LaRosa SP, Creasey AA, Xie F, Poole L, Wunderink RG Critical Care 2009, 13 :R36 (15 March 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Poster presentation
Defining severe community-acquired pneumonia: a significant barrier to improving patient outcomes Balp MM, Naujoks C Critical Care 2009, 13 (Suppl 1):P348 (13 March 2009) [Full text ] [PDF ]
Research
High sensitivity detection of Plasmodium species reveals positive correlations between infections of different species, shifts in age distribution and reduced local variation in Papua New Guinea Mueller I, Widmer S, Michel D, Maraga S, McNamara DT, Kiniboro B, Sie A, Smith TA, Zimmerman PA Malaria Journal 2009, 8 :41 (11 March 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum Dharia NV, Sidhu ABS, Cassera MB, Westenberger SJ, Bopp SER, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA Genome Biology 2009, 10 :R21 (13 February 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction Weiss A, Roscic A, Paganetti P Molecular Neurodegeneration 2009, 4 :11 (9 February 2009) [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus Pezacki JP, Sagan SM, Tonary AM, Rouleau Y, Bélanger S, Supekova L, Su AI BMC Chemical Biology 2009, 9 :2 (16 January 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue Chène P, Rudloff J, Schoepfer J, Furet P, Meier P, Qian Z, Schlaeppi JM, Schmitz R, Radimerski T BMC Chemical Biology 2009, 9 :1 (7 January 2009) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
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dimerization/docking domain reveals molecular details of isoform-specific anchoring
