The microRNAs miR-145, miR-126, miR-24 and miR-23a are selectively expressed in microvascular fragments in vivo, and miR-145 blocks migration in response to growth factor gradients, offering a novel therapeutic candidate for vascular disease.

A high throughput 3-D culture system succeeds in establishing glandular acini from a human mammary epithelial cell line, and demonstrates the importance of basal polarity-mediated signals and collagen IV in recapitulating apical polarity.

Technological advances in genome-wide methylation profiling are likely to lead to a better understanding of the importance of DNA methylation in cancer as a disease marker or a tumorigenesis driver.

Mice with a knockout in the PKCI/HINT1 gene display anxiolytic, anti-depressant like and goal-oriented behaviors, that in conjunction with elevated corticosterone levels, suggest a role for this gene in mood regulation.

Single nucleotide polymorphisms of the clock gene RAR-related orphan receptor beta are associated with pediatric bipolar disorder, which suggests a role for circadian clock genes in the development of the condition.