Systems Biology Gateway

Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.


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  • Mitochondrial transcriptome in pediatric septic shock

    Nuclear-encoded mitochondrial genes are differentially expressed early in pediatric septic shock compared with healthy controls, indicating the nuclear genome may be an important mechanism contributing to alterations in mitochondrial bioenergetic function and outcomes in pediatric sepsis.

    Critical Care 2014, 18:623
  • Translational tuberculosis genomics

    Valerie Mizrahi and Digby Warner discuss genomic insights into tuberculosis, and the challenges that remain for controlling the disease in endemic regions

    Genome Biology 2014, 15:514
  • Image attributed to: From the review by Julian Knight

    From GWAS to function

    Julian Knight describes approaches for identifying and functionally characterizing regulatory variants, covering methods from epigenomic landscape information to the use of quantitative trait mapping.

    Genome Medicine 2014, 6:92
  • CIITA genomic mapping

    CIITA has a broader role beyond the MHC which involves immune related genes and is regulated in an allele specific manner

    Genome Biology 2014, 15:494
  • Modeling histone modification pattern formation

    Cooperative interactions between regulatory proteins and the chromatin state generate complex stochastic dynamics of gene expression regulation.

    Epigenetics & Chromatin 2014, 7:30

News and events

Da_Vinci_Vitruvian_man_clip Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'

The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.

Beyond the Genome 2013