Systems Biology Gateway
Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.
Guest Editor Martin Hibberd highlights advances in genomics, metagenomics and other high-throughput approaches for studying human-microbe interactions in health and disease, and the applications for medicine.
From GWAS to Neanderthal genomes: Fisher and Deriziotis review what genomics can teach us about speech, language and their associated disorders
The optimization and visualization of edge weights in optimal assignment methods is a valuable approach for ligandbased virtual screening experiments and provides a useful tool for drug discovery.
Edwards and Thiele define Systems Biology as "an iterative process of computational model-building and experimental model-revision with the aim of understanding or simulating complex biological systems". Further, they highlight the limited number of physiologically relevant perturbations that are ethically acceptable in humans and highlight the value of environmental and exertional stressors in this context.
Serum metabolite profiles differ between smokers and non-smokers, and these changes are reversible after stopping smoking, suggesting the metabolites could be used as biomarkers to measure success of cessation interventions and evaluate disease risk.
News and events
GigaScience, an innovative new journal being launched by BioMed Central and BGI, is now accepting submissions. Edited by Dr Laurie Goodman, GigaScience publishes research relating to biological 'big-data' studies, whilst promoting an integrated database to enable rapid release and permanency of data, and providing a forum for dealing with the difficulties of handling such large-scale data.