Systems Biology Gateway
Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.
In their open peer reviewed correspondence piece, Tagu and colleagues discuss the opportunities afforded by neoENCODE initiatives to understand how genetic systems react in the natural context of living ecosystems. Do comment!
Corti and colleagues review the experimental approaches for differentiating human embryonic stem cells and human induced pluripotent stem cells towards functional motor neurons, and summarise their potential clinical applications.
Transcriptomic responses to flg22 in wild type, mpk3, mpk4 and mpk6 plants determines how SA signaling and callose deposition are regulated
Variations in human genome sequence have been related to some diseases but little is known about the mechanisms; here Georges St. Laurent and colleagues review non-protein coding functional RNAs and suggest these may play a yet undiscovered role in disease.
With increased understanding that epigenetic modifications and non-coding RNAs play a significant role in determining phenotypes, is it now time to create next generation genetic databases that accurately evaluate heterogeneity?
News and events
Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'
The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.