Systems Biology Gateway
Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.
The DM system, crucial for immune system function in humans and mice, is not present in the MHC class II genes of teleost fish, implying a strong split in immune function between tetrapods and other vertebrates.
A new dense physical map of the wallaby genome provides strong evidence for a karyotype of 2n = 14 for the first marsupials, adding to our understanding of genome evolution in both marsupials and eutherians.
Spectral tuning in the visual system of the Great Bowerbird confirms that UV sensitivity has re-evolved from violet sensitive ancestors several times in birds, something unknown in other vertebrates.
The evolution of novelty has long been a problem for the theory of natural selection. Marc Kirschner, in an interview, reviews the ways in which it can be explained by selection for evolvability without recourse to the heresy of anticipation of function, and why the study of evolvability is of practical importance.
Two novel protein biomarker panels discriminate early and late onset preeclampsia (PE) with better performance than existing markers, suggesting these panels can be used to diagnose PE accurately and monitor disease progression.
News and events
Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'
The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.