Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera

A global screen of mutant fitness in Neisseria meningitidis was used to construct a genome-scale metabolic network

Evolution of biological interaction networks: from models to real data

Sun and Kim review progress in the study of biological network evolution, with a focus on the protein-protein interaction network

Metabonomics adds a new dimension to fragile X syndrome

Frank Kooy and colleagues highlight a recent study that provides new insights into the mechanisms underlying Fragile X syndrome through the metabolomics analysis of mouse models.

Genomics in 2011: challenges and opportunities

Several members of the Genome Biology Editorial Board give their views on the state of play in genomics

RNA-seq in grain unveils fate of neo- and paleopolyploidization events in bread wheat (Triticum aestivum L.)

Transcriptomics reveals the evolutionary trajectory of polyploidization, with insights into gene networks and genome organization