Systems Biology Gateway
Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.
Blood transcriptional profiling of patients with sepsis, including survivors and non-survivors, reveals survival is associated with a strong immune response and with missense variants in VPS9D1.
A new database, the most comprehensive and thorough analysis of mitochondrial gene content to date, has implications for the deep phylogeny of eukaryotes and provides an important resource for researchers in genome evolution.
Massey and Read discuss the recent advances and remaining challenges in the field of bacterial GWAS and propose strategies to improve the validation and dissect mechanism.
Nuclear-encoded mitochondrial genes are differentially expressed early in pediatric septic shock compared with healthy controls, indicating the nuclear genome may be an important mechanism contributing to alterations in mitochondrial bioenergetic function and outcomes in pediatric sepsis.
Valerie Mizrahi and Digby Warner discuss genomic insights into tuberculosis, and the challenges that remain for controlling the disease in endemic regions
News and events
Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'
The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.