Systems Biology Gateway

Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.


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  • A phenomic approach to improving drug therapy

    Discussing a novel integrated approach to personalized medicine that begins with phenomic data, is stratified by genomics, and is ultimately refined by metabolomic pathway data.

    Human Genomics 2014, 8:16
  • OrthoClust

    Mark Gerstein and colleagues describe a new orthology-based framework for cross-species clustering

    Genome Biology 2014, 15:R100
  • Copy number evolution

    An analysis of the evolution of DNA copy numbers in the fruit fly

    Genome Biology 2014, 15:R70
  • Image attributed to: Detail of Figure 5 from Deavidsen et al.

    Insights into muscle wasting in COPD

    A systems biology approach comparing muscle transcriptional profiles in the chronic cigarette smoke guinea pig model and COPD patients suggests the involvement of CXCL10 and CXCL9 in muscle wasting.

    Genome Medicine 2014, 6:59
  • Image attributed to: Bro Jeffrey Pioquinto, SJ_Flickr cc

    Next-generation training in biophysics

    An innovative graduate training program in biophysics and structural biology aims to integrate students in activities usually undertaken by more senior faculty members, empowering them to become better prepared for a career in academia.

    BMC Biophysics 2014, 7:6

News and events

Da_Vinci_Vitruvian_man_clip Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'

The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.

Beyond the Genome 2013