Systems Biology Gateway

Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.


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  • Image attributed to: Taken from

    Beyond ENCODE?

    In their open peer reviewed correspondence piece, Tagu and colleagues discuss the opportunities afforded by neoENCODE initiatives to understand how genetic systems react in the natural context of living ecosystems. Do comment!

    BMC Genomics 2014, 15:490
  • Motor neuron derivation and application

    Corti and colleagues review the experimental approaches for differentiating human embryonic stem cells and human induced pluripotent stem cells towards functional motor neurons, and summarise their potential clinical applications.

    Stem Cell Research & Therapy 2014, 5:87
  • Plant immune responses

    Transcriptomic responses to flg22 in wild type, mpk3, mpk4 and mpk6 plants determines how SA signaling and callose deposition are regulated

    Genome Biology 2014, 15:R87
  • Image attributed to: Wikimedia;Richard Feldmann, NCI

    Role for non-protein coding RNAs?

    Variations in human genome sequence have been related to some diseases but little is known about the mechanisms; here Georges St. Laurent and colleagues review non-protein coding functional RNAs and suggest these may play a yet undiscovered role in disease.

    BMC Medicine 2014, 12:97
  • Evolving genetic paradigms

    With increased understanding that epigenetic modifications and non-coding RNAs play a significant role in determining phenotypes, is it now time to create next generation genetic databases that accurately evaluate heterogeneity?

    Human Genomics 2014, 8:9

News and events

Da_Vinci_Vitruvian_man_clip Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'

The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.

Beyond the Genome 2013