The Drosophila circadian clock protein CLOCK is expressed exclusively in circadian neurons during embryogenesis and is present prior to the period gene PER, suggesting it is a key factor in the early development of the circadian system.

Decreased postnatal neurogenesis increases vulnerability to stress and may result in adults predisposed to develop psychiatric disorders.

Increased expression of cellular retinoic acid binding protein 1 (CRABP1) in response to beta-amyloid peptide over-expression induces cell proliferation and reduced differentiation potential in human neuroblastoma cells, suggesting a potential mechanism for neurogenesis in Alzheimer's disease.

Intranasal administration of transforming growth factor-beta1 (TGF-beta1) results in reduced infarct volume, improved neuroprotection and enhanced neurogenesis in adult mice after stroke, which may have therapeutic potential for cerebrovascular disorders.

Function assertive community treatment (FACT), the Dutch variant of ACT, is a more effective form of treatment than standard therapy in patients with severe mental illness who have an unmet need for care of psychotic symptoms.

Dr Bill Harris
Cambridge University, United Kingdom

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