4.0 s446 PROTEIN pr12 s444 PROTEIN pr3 s444 PROTEIN pr1 s446 PROTEIN pr5 s396 PROTEIN pr12 s396 PROTEIN pr10 s396 PROTEIN pr11 s443 PROTEIN pr52 s443 PROTEIN pr14 s390 PROTEIN pr3 s390 PROTEIN pr1 s445 PROTEIN pr16 s444 PROTEIN pr12 s444 PROTEIN pr17 s398 PROTEIN pr3 s396 PROTEIN pr1 s398 PROTEIN pr8 s385 SIMPLE_MOLECULE GTP s365 PROTEIN pr88 s385 PROTEIN pr88 s365 SIMPLE_MOLECULE GDP s387 PROTEIN pr5 s421 PROTEIN pr12 s387 PROTEIN pr6 s446 PROTEIN pr1 s445 PROTEIN pr12 s445 PROTEIN pr3 s445 PROTEIN pr1 s421 PROTEIN pr3 s421 PROTEIN pr1 s428 PROTEIN pr9 s428 PROTEIN pr13 s455 PROTEIN pr1 s455 PROTEIN pr3 s455 PROTEIN pr12 s446 PROTEIN pr3 s398 PROTEIN pr1 s387 PROTEIN pr12 s396 PROTEIN pr3 s398 PROTEIN pr12 s388 PROTEIN pr12 s388 PROTEIN pr6 s664 PROTEIN pr10 s664 PROTEIN pr11 s667 PROTEIN pr1 s667 PROTEIN pr12 s667 PROTEIN pr3 s724 PROTEIN pr110 s724 PROTEIN pr111 s735 PROTEIN pr12 s735 PROTEIN pr3 s735 PROTEIN pr1 s735 PROTEIN pr124 SQUARE_CLOSEUP_NORTH SQUARE SQUARE inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive active active active active active active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive active active active active active inactive inactive inactive active active active active active inactive inactive inactive active inactive inactive inactive inactive inactive active active active active active inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive Catalysis state transition complex association unknown inhibition modulation trigger transcription unknown catalysis inhibition phosphorylation Plasma Membrane Nucleus c5 inside PROTEIN pr50 inside PROTEIN pr56 inside PROTEIN pr48 inside PROTEIN pr45 inside PROTEIN pr44 inside PROTEIN pr43 inside PROTEIN pr22 inside PROTEIN pr35 inside PROTEIN pr28 inside PROTEIN pr21 inside PROTEIN pr29 inside PROTEIN pr27 inside PROTEIN pr20 inside PROTEIN pr47 inside PROTEIN pr33 inside PROTEIN pr14 inside PROTEIN pr16 inside PROTEIN pr25 inside PROTEIN pr23 inside PROTEIN pr24 inside PROTEIN pr6 inside PROTEIN pr37 inside PROTEIN pr41 inside PROTEIN pr31 inside PROTEIN pr5 inside PROTEIN pr42 inside PROTEIN pr13 inside PROTEIN pr40 inside PROTEIN pr8 inside ION Ca++ inside SIMPLE_MOLECULE DAG inside SIMPLE_MOLECULE cAMP inside PROTEIN pr18 inside PROTEIN pr1 inside PROTEIN pr3 inside SIMPLE_MOLECULE IP3 inside SIMPLE_MOLECULE PI3,4,5-P2 inside PROTEIN pr27 inside PROTEIN pr82 inside PROTEIN pr82 inside PROTEIN pr25 inside PROTEIN pr20 inside PROTEIN pr23 inside PROTEIN pr50 inside PROTEIN pr48 inside PROTEIN pr18 inside SIMPLE_MOLECULE ATP inside PROTEIN pr31 inside PROTEIN pr85 inside PROTEIN pr85 inside SIMPLE_MOLECULE GTP inside SIMPLE_MOLECULE GDP inside COMPLEX RHEB-GDP inside PROTEIN pr33 inside PROTEIN pr43 inside COMPLEX RHEB-GTP transmembrane COMPLEX true AKT2_FSHR_APPL1 innerSurface COMPLEX FSHR_APPL1 inside COMPLEX CGA_FSHB transmembrane COMPLEX CGA_FSB_FSHR_ARRB2_ARRB1 transmembrane COMPLEX CGA_FSHB_FSHR_ARR3 inside PROTEIN pr37 inside PROTEIN pr35 outerSurface COMPLEX CGA_FSHB_FSHR inside PROTEIN pr9 inside COMPLEX PRKAR1A_RARA inside PROTEIN pr22 inside PROTEIN pr28 inside PROTEIN pr41 inside PROTEIN pr42 inside PROTEIN pr45 inside PROTEIN pr56 inside PROTEIN pr21 inside COMPLEX TGM2_PLCD1 transmembrane COMPLEX CGA_FSHB_FSHR_GRK6 transmembrane COMPLEX CGA_FSHB_FSHR_GRK4 transmembrane COMPLEX CGA_FSHB_FSHR_AKT2 outerSurface COMPLEX CGA_FSHB_FSHR_CGA_FSHB_FSHR inside PROTEIN pr10 inside PROTEIN pr17 inside PROTEIN pr29 inside PROTEIN pr51 inside PROTEIN pr57 inside PROTEIN pr55 inside PROTEIN pr38 inside PROTEIN pr15 inside PROTEIN pr39 inside PROTEIN pr49 inside PROTEIN pr83 inside PROTEIN pr84 inside PROTEIN pr95 inside PROTEIN pr52 inside PROTEIN pr53 inside PROTEIN pr46 innerSurface PROTEIN pr15 inside PHENOTYPE Steroidogenesis inside PROTEIN pr57 inside PROTEIN pr98 inside PROTEIN pr99 inside COMPLEX ARRB1_ARRB2 transmembrane COMPLEX CGA_FSHB_FSHR inside PROTEIN pr110 inside PROTEIN pr111 inside PROTEIN pr112 inside PHENOTYPE phenotype inside ION ion inside PROTEIN pr113 inside COMPLEX complex inside SIMPLE_MOLECULE simple molecule inside PROTEIN pr118 inside PROTEIN pr119 inside PROTEIN pr13 inside PROTEIN pr44 inside PROTEIN pr97 inside PROTEIN pr123 inside PROTEIN pr12 inside PROTEIN pr11 inside PROTEIN pr11 inside PROTEIN pr39 inside PROTEIN pr40 inside PROTEIN pr24 inside PROTEIN pr46 inside PROTEIN pr95 inside PROTEIN pr123 inside COMPLEX A_B inside PROTEIN pr124 transmembrane COMPLEX CGA_FSHB_FSHR_YWHAQ inside PROTEIN pr47 PMID: 12374801 HETERODIMER_ASSOCIATION 0.20497917440852342,0.4720178372352253 sa57 sa56 csa10 HETERODIMER_ASSOCIATION 0.43131464143915466,0.34280182344002696 sa49 sa50 csa7 PMID: 15662415 PMID: 18199880 HETERODIMER_ASSOCIATION 0.3862362469152112,0.19993842518312466 0.7337983215595067,0.09500395076750756 csa10 sa58 csa2 HETERODIMER_ASSOCIATION 0.7632901526438509,-0.1805295912464312 0.4515758031322239,0.05670368426239336 -11.688739421349268,-2.751394685138271 csa4 csa2 csa3 PMID: 12850288 HETERODIMER_ASSOCIATION 0.5309817116720681,0.31357340694985725 0.5065641481202903,-0.36670092854322056 0.7130701105196844,0.05478426307131734 csa2 sa51 csa1 PMID: 16899567 HETERODIMER_ASSOCIATION 0.8656680093512155,0.11933079602266783 0.5947993450658338,-0.23683679750989495 0.48977723865132794,0.3950355820126812 csa2 csa23 csa6 PMID: 15070827 HETERODIMER_ASSOCIATION 0.7771290339436501,0.39664168116509746 -0.1414662386190333,0.4310825746013376 sa58 sa34 csa8 csa10 PMID: 16709602 HETERODIMER_ASSOCIATION 0.1646870403167391,0.30537164681345264 sa7 sa25 csa9 csa2 HETERODIMER_ASSOCIATION 0.8293932265468371,-0.16574049556491488 0.4928049573158537,-0.2908409397761371 csa2 sa42 csa5 DISSOCIATION 0.3318401592718807,0.3531119643534453 sa60 sa59 sa53 sa25 STATE_TRANSITION sa59 sa52 PMID: 16525034 PMID: 14681202 PMID: 11144213 PMID: 10230816 STATE_TRANSITION sa3 sa61 sa52 sa53 PMID: 19671624 PMID: 16525034 PMID: 11498542 PMID: 20434519 PMID: 18818282 PMID: 17536007 STATE_TRANSITION sa21 sa62 sa66 sa65 sa61 PMID: 16525034 PMID: 11498542 PMID: 20434519 PMID: 18818282 PMID: 17536007 STATE_TRANSITION sa63 sa64 sa61 sa66 sa65 PMID: 16525034 STATE_TRANSITION sa31 sa65 sa68 PMID: 19671624 STATE_TRANSITION sa28 sa66 sa68 PMID: 17536007 STATE_TRANSITION sa22 sa67 csa4 PMID: 16525034 STATE_TRANSITION sa40 sa68 sa69 PMID: 16525034 STATE_TRANSITION sa2 sa69 sa67 PMID: 17536007 STATE_TRANSITION sa18 sa70 csa4 PMID: 16525034 STATE_TRANSITION sa8 sa71 sa62 PMID: 17536007 STATE_TRANSITION sa15 sa72 csa4 PMID: 10379886 HETERODIMER_ASSOCIATION 0.8789006159640773,-0.24430157504661357 0.12853297458041846,-0.6244900963583364 sa27 csa4 csa12 sa27 PMID: 10379886 HETERODIMER_ASSOCIATION 0.8229479439936256,-0.24580492124674147 1.7340001787094814,-0.9097491801431283 csa4 sa41 csa13 sa41 PMID: 12493768 STATE_TRANSITION sa17 sa117 sa62 sa64 PMID: 16525034 STATE_TRANSITION sa55 sa118 csa4 PMID: 16525034 PMID: 7918869 STATE_TRANSITION sa119 sa120 sa61 STATE_TRANSITION sa121 sa54 sa123 STATE_TRANSITION sa122 sa123 csa2 STATE_TRANSITION sa124 sa125 sa54 PMID: 18845636 PMID: 18818282 PMID: 14982927 PMID: 18574502 PMID: 17536007 PMID: 17283241 STATE_TRANSITION sa38 sa126 sa125 PMID: 17510244 PMID: 14982927 STATE_TRANSITION sa129 sa130 sa126 PMID: 14982927 STATE_TRANSITION 0.3654970760234013,0.0065789473684105815 0.6432748538011746,0.0065789473684105815 csa14 sa148 csa17 sa149 sa130 PMID: 17283241 STATE_TRANSITION sa24 sa151 csa14 PMID: 15774499 PMID: 17283241 PMID: 9892015 PMID: 14982927 STATE_TRANSITION sa153 sa154 sa151 PMID: 14982927 PMID: 8603610 STATE_TRANSITION sa35 sa155 sa154 PMID: 11498542 STATE_TRANSITION sa16 sa156 sa151 PMID: 14982927 STATE_TRANSITION sa4 sa158 sa151 PMID: 14982927 STATE_TRANSITION sa30 sa159 sa151 PMID: 15070827 HETERODIMER_ASSOCIATION 0.7018316012946197,-0.019507695254791457 sa42 csa8 csa18 PMID: 10935551 STATE_TRANSITION sa14 sa165 sa126 PMID: 18845636 STATE_TRANSITION sa12 sa166 sa126 PMID: 15070827 PMID: 17536007 PMID: 17283241 STATE_TRANSITION sa36 sa167 sa126 PMID: 17283241 STATE_TRANSITION sa43 sa168 sa126 TRANSPORT sa23 sa294 sa126 PMID:10379886 STATE_TRANSITION 0.8546085303978401,0.03345464976603396 csa4 csa21 sa178 PMID: 9645711 PMID: 20434519 PMID: 19022884 PMID: 17536007 PMID: 10935551 STATE_TRANSITION sa20 sa182 sa61 PMID: 9645711 STATE_TRANSITION sa187 sa13 sa182 STATE_TRANSITION sa37 sa190 sa54 PMID: 20215566 HETERODIMER_ASSOCIATION 0.8513065868327017,0.14340529639417188 0.5309544990877364,0.27555111854371095 sa32 sa46 csa22 csa4 PMID: 16020485 PMID: 11498542 STATE_TRANSITION sa47 sa193 sa190 csa4 PMID: 17261351 STATE_TRANSITION sa1 sa194 csa2 PMID: 17283241 PMID: 12493768 PMID: 11498542 PMID: 19324971 STATE_TRANSITION sa11 sa196 sa190 PMID: 7918869 PMID: 16269516 STATE_TRANSITION sa6 sa197 sa126 PMID: 16474210 STATE_TRANSITION sa48 sa199 sa37 PMID: 18927218 STATE_TRANSITION sa198 sa200 sa126 PMID: 17110429 STATE_TRANSITION sa9 sa201 sa4 TRANSPORT csa7 csa23 TRANSPORT sa44 sa178 csa4 TRIGGER sa197 sa204 TRANSCRIPTION sa196 sa206 TRANSCRIPTION sa196 sa207 TRANSCRIPTION sa196 sa208 state transition STATE_TRANSITION sa253 sa255 STATE_TRANSITION sa252 sa254 sa256 STATE_TRANSITION sa260 sa261 sa265 HETERODIMER_ASSOCIATION 0.25982963040639007,0.41317851096206937 sa259 sa266 csa24 STATE_TRANSITION sa234 sa235 sa236 STATE_TRANSITION sa241 sa240 sa242 TRANSCRIPTION sa239 sa238 STATE_TRANSITION sa279 sa280 sa278 STATE_TRANSITION sa282 sa283 sa281 PMID: 20215566 STATE_TRANSITION sa46 sa286 sa190 PMID: 16899567 STATE_TRANSITION sa288 sa49 csa2 HETERODIMER_ASSOCIATION 0.061260342295092696,0.16020224163783814 0.9131454375799362,0.2400760990237164 0.8038231607319712,0.1064153079127359 csa2 sa289 csa27