GENE_ASSOCIATION: SP10210025V04 PROTEIN_ASSOCIATION: glucokinase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210025V04 PROTEIN_ASSOCIATION: glucokinase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60150017V04 or SP70090036V04 PROTEIN_ASSOCIATION: fructose-1,6-bisphosphatase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 3.1.3.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10240019V04 PROTEIN_ASSOCIATION: fructose-1,6-bisphosphate aldolase class II SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 4.1.2.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150085V04 PROTEIN_ASSOCIATION: triosephosphate isomerase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 5.3.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170051V04 or SP30090011V04 PROTEIN_ASSOCIATION: glyceraldehyde 3-phosphate dehydrogenase 1 (NAD+) SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 1.2.1.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080027V04 PROTEIN_ASSOCIATION: phosphoglycerate kinase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.2.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170004V04 or SP20170005V04 or SP20180101V04 PROTEIN_ASSOCIATION: phosphoglycerate mutase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 5.4.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030049V04 PROTEIN_ASSOCIATION: enolase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 4.2.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110087V04 or SP70130001V04 PROTEIN_ASSOCIATION: pyruvate kinase 1 SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 2.7.1.40 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10430021V04 or SP20240003V04 or SP70150019V04 PROTEIN_ASSOCIATION: phosphoenolpyruvate synthase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 2.7.9.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70150028V04 PROTEIN_ASSOCIATION: glucose-6-phosphate isomerase SUBSYSTEM: S_Glycolysis PROTEIN_CLASS: 5.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70150028V04 PROTEIN_ASSOCIATION: glucose-6-phosphate isomerase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 5.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70150028V04 PROTEIN_ASSOCIATION: glucose-6-phosphate isomerase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 5.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70140037V04 PROTEIN_ASSOCIATION: alpha-amylase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 3.2.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20140017V04 or SP40090065V04 or SP60140021V04 or SP80060231V04 or SP60140022V04 PROTEIN_ASSOCIATION: glycogen phosphorylase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 2.4.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20140017V04 or SP40090065V04 PROTEIN_ASSOCIATION: glycogen phosphorylase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 2.4.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70040042V04 PROTEIN_ASSOCIATION: glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 2.7.7.27 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140021V04 or SP80060231V04 PROTEIN_ASSOCIATION: 1,4-alpha-glucan branching enzyme SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 2.4.1.18 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290048V04 or SP20250076V04 or SP80100003V04 or SP80100004V04 PROTEIN_ASSOCIATION: glycogen synthase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 2.4.1.21 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60130045V04 or SP60160004V04 or SP20110165V04 PROTEIN_ASSOCIATION: Glycogen debranching enzyme SUBSYSTEM: S_Gluconeogenesis PROTEIN_CLASS: 3.2.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090200V04 PROTEIN_ASSOCIATION: UDP-glucose-1,4-beta-glucan glucosyltransferase SUBSYSTEM: S_Gluconeogenesis (exclude glycolysis rxn) PROTEIN_CLASS: 2.4.1.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110005V04 or SP40090039V04 PROTEIN_ASSOCIATION: phosphoglucomutase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 5.4.2.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60150015V04 or SP60150016V04 PROTEIN_ASSOCIATION: glucose-6-phosphate 1-dehydrogenase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 1.1.1.49 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10150033V04 PROTEIN_ASSOCIATION: 6-phosphogluconolactonase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 3.1.1.31 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40090061V04 PROTEIN_ASSOCIATION: 6-phosphogluconate dehydrogenase, decarboxylating SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 1.1.1.44 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250020V04 PROTEIN_ASSOCIATION: pentose-5-phosphate-3-epimerase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 5.1.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090109V04 PROTEIN_ASSOCIATION: ribose 5-phosphate isomerase A SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 5.3.1.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50060003V04 or SP70050013V04 or SP70180120V04 PROTEIN_ASSOCIATION: transketolase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 2.2.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50060003V04 or SP70050013V04 or SP70180120V04 PROTEIN_ASSOCIATION: transketolase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 2.2.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210023V04 PROTEIN_ASSOCIATION: fructose-6-phosphate phosphoketolase SUBSYSTEM: S_Pentose phosphate pathway/ carbon fixation PROTEIN_CLASS: 4.1.2.22 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30090015V04 or SP70050010V04 PROTEIN_ASSOCIATION: transaldolase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 2.2.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80080007V04 PROTEIN_ASSOCIATION: deoxyribose-phosphate aldolase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 4.1.2.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040021V04 PROTEIN_ASSOCIATION: 2-keto-3-deoxygluconate 6-phosphate aldolase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 4.1.2.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: phosphogluconate dehydratase SUBSYSTEM: S_Pentose phosphate pathway PROTEIN_CLASS: 4.2.1.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210023V04 PROTEIN_ASSOCIATION: phosphoketolase SUBSYSTEM: S_Pentose phosphate pathway/ carbon fixation PROTEIN_CLASS: 4.1.2.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090164V04 PROTEIN_ASSOCIATION: citrate synthase SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 2.3.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20160006V04 PROTEIN_ASSOCIATION: malate dehydrogenase SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 1.1.1.37 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240060V04 PROTEIN_ASSOCIATION: aconitate hydratase SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 4.2.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240060V04 PROTEIN_ASSOCIATION: aconitate hydratase SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 4.2.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060069V04 PROTEIN_ASSOCIATION: isocitrate dehydrogenase (NADP) SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 1.1.1.42 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170019V04 PROTEIN_ASSOCIATION: fumarate hydratase SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 4.2.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150008V04 PROTEIN_ASSOCIATION: succinate dehydrogenase iron-sulfur protein SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 1.3.99.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70060044V04 and SP70060045V04 PROTEIN_ASSOCIATION: succinyl-CoA synthetase alpha chain SUBSYSTEM: S_Tricarboxylic Acid Cycle (TCA cycle) / Citric Acid Cycle PROTEIN_CLASS: 6.2.1.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10090051V04 PROTEIN_ASSOCIATION: acetaldehyde dehydrogenase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 1.2.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040021V04 PROTEIN_ASSOCIATION: oxaloacetate decarboxylase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 4.1.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060075V04 PROTEIN_ASSOCIATION: pyruvate formate-lyase activating enzyme SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 1.97.1.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060077V04 PROTEIN_ASSOCIATION: formate C-acetyltransferase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 2.3.1.54 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030050V04 PROTEIN_ASSOCIATION: 2-hydroxyaciddehydrogenase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 1.1.1.28 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190007V04 or SP10190008V04 PROTEIN_ASSOCIATION: acetyl-coenzyme A synthetase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 6.2.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210016V04 and SP20240019V04 and SP10390034V04 PROTEIN_ASSOCIATION: Pyruvate dehydrogenase complex SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 2.7.11.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210020V04 PROTEIN_ASSOCIATION: acetate kinase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 2.7.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70150026V04 PROTEIN_ASSOCIATION: phosphotransacetylase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 2.3.1.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10090050V04 or SP20110060V04 or SP10090051V04 PROTEIN_ASSOCIATION: formaldehyde dehydrogenase (glutathione) / alcohol dehydrogenase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 1.1.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10260027V04 PROTEIN_ASSOCIATION: pyruvate synthase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 1.2.7.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010033V04 PROTEIN_ASSOCIATION: phosphoenolpyruvate carboxylase SUBSYSTEM: S_Anaplerotic Reactions PROTEIN_CLASS: 4.1.1.31 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60150003V04 PROTEIN_ASSOCIATION: malic enzyme SUBSYSTEM: S_Anaplerotic Reactions PROTEIN_CLASS: 1.1.1.38 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20060009V04 PROTEIN_ASSOCIATION: inorganic pyrophosphatase SUBSYSTEM: S_Anaplerotic Reactions PROTEIN_CLASS: 3.6.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110132V04 and SP20180126V04 and SP70050028V04 PROTEIN_ASSOCIATION: acetolactate synthase small subunit SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 2.2.1.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30010023V04 or SP30010024V04 PROTEIN_ASSOCIATION: ketol-acid reductoisomerase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 1.1.1.86 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090293V04 PROTEIN_ASSOCIATION: dihydroxy-acid dehydratase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 4.2.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110132V04 and SP20180126V04 and SP70050028V04 PROTEIN_ASSOCIATION: acetolactate synthase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 2.2.1.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30010023V04 or SP30010024V04 PROTEIN_ASSOCIATION: ketol-acid reductoisomerase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 1.1.1.86 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090293V04 PROTEIN_ASSOCIATION: dihydroxyacid dehydratase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 4.2.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70010008V04 PROTEIN_ASSOCIATION: branched-chain amino acid aminotransferase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 2.6.1.42 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030068V04 PROTEIN_ASSOCIATION: valine-pyruvate aminotransferase SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 2.6.1.66 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090167V04 PROTEIN_ASSOCIATION: alanine racemase SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 5.1.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190073V04 or SP20040127V04 or SP20210004V04 or SP40010032V04 or SP70090029V04 PROTEIN_ASSOCIATION: aspartate aminotransferase SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 2.6.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60070113V04 or SP70130006V04 PROTEIN_ASSOCIATION: asparagine synthetase SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 6.3.5.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80010026V04 PROTEIN_ASSOCIATION: asparaginase SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 3.5.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20060002V04 PROTEIN_ASSOCIATION: aspartate 1-decarboxylase SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 4.1.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20200030V04 PROTEIN_ASSOCIATION: alanine dehydrogenase SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 1.4.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040009V04 or SP30140212V04 or SP30050025V04 or SP10040006V04 or SP20150015V04 or SP80030018V04 PROTEIN_ASSOCIATION: cysteine desulfrase, NifS protein, facilitates iron-sulfur cluster assembly SUBSYSTEM: S_Alanine Aspartate and Asparagine Metabolism PROTEIN_CLASS: 2.8.1.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70010008V04 PROTEIN_ASSOCIATION: branched-chain amino acid aminotransferase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 2.6.1.42 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70010008V04 PROTEIN_ASSOCIATION: branched-chain amino acid aminotransferase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 2.6.1.42 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380065V04 PROTEIN_ASSOCIATION: 3-isopropylmalate dehydrogenase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 1.1.1.85 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380065V04 PROTEIN_ASSOCIATION: 3-isopropylmalate dehydrogenase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: spontaneous2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60070107V04 and SP60070108V04 PROTEIN_ASSOCIATION: 3-isopropylmalate dehydratase large subunit SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 4.2.1.33 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60070107V04 and SP60070108V04 PROTEIN_ASSOCIATION: 3-isopropylmalate dehydratase large subunit SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 4.2.1.33 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60130055V04 or SP70050029V04 PROTEIN_ASSOCIATION: 2-isopropylmalate synthase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 2.3.3.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10330017V04 or SP70090150V04 PROTEIN_ASSOCIATION: L-threonine deaminase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 4.3.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60070103V04 PROTEIN_ASSOCIATION: 3-hydroxyisobutyrate dehydrogenase SUBSYSTEM: S_Valine, Leucine, and Isoleucine Metabolism PROTEIN_CLASS: 1.1.1.31 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040064V04 PROTEIN_ASSOCIATION: ATP phosphoribosyltransferase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 2.4.2.17 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040045V04 or SP20040044V04 PROTEIN_ASSOCIATION: phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 3.6.1.31 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040045V04 or SP20040044V04 PROTEIN_ASSOCIATION: phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 3.5.4.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10240034V04 PROTEIN_ASSOCIATION: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 5.3.1.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50010016V04 or SP60150005V04 or SP70180097V04 or SP80010051V04 or SP10170015V04 PROTEIN_ASSOCIATION: amidotransferase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 2.4.2.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220041V04 or SP30170018V04 PROTEIN_ASSOCIATION: imidazoleglycerol-phosphate dehydratase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 4.2.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030038V04 or SP30050026V04 PROTEIN_ASSOCIATION: histidinol phosphate aminotransferase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 2.6.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220041V04 or SP30170018V04 PROTEIN_ASSOCIATION: histidinol-phosphatase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 3.1.3.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090226V04 PROTEIN_ASSOCIATION: histidinol dehydrogenase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 1.1.1.23 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090226V04 PROTEIN_ASSOCIATION: histidinol dehydrogenase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 1.1.1.23 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40050012V04 PROTEIN_ASSOCIATION: glutamate-ammonia ligase, glutamine synthetase type III SUBSYSTEM: S_Glutamate and Glutamine metabolism PROTEIN_CLASS: 6.3.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70080022V04 PROTEIN_ASSOCIATION: NADP-specific glutamate dehydrogenase SUBSYSTEM: S_Glutamate and Glutamine metabolism PROTEIN_CLASS: 1.4.1.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70080022V04 PROTEIN_ASSOCIATION: NADP-specific glutamate dehydrogenase SUBSYSTEM: S_Glutamate and Glutamine metabolism PROTEIN_CLASS: 1.4.1.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030078V04 PROTEIN_ASSOCIATION: glutaminase SUBSYSTEM: S_Glutamate and Glutamine metabolism PROTEIN_CLASS: 3.5.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190040V04 PROTEIN_ASSOCIATION: ferredoxin-dependent glutamate synthase SUBSYSTEM: S_Glutamate and Glutamine metabolism PROTEIN_CLASS: 1.4.7.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40090019V04 PROTEIN_ASSOCIATION: phosphoadenosine phosphosulfate reductase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 1.8.4.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20210002V04 or SP70180067V04 PROTEIN_ASSOCIATION: alanyl aminopeptidase (cys-gly) SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 3.4.11.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10100018V04 PROTEIN_ASSOCIATION: glutamate 5-kinase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.7.2.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350092V04 or SP10440009V04 PROTEIN_ASSOCIATION: glutamate-5-semialdehyde dehydrogenase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.2.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: spontaneous PROTEIN_ASSOCIATION: L-glutamate 5-semialdehyde dehydratase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: spontaneous1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10020005V04 PROTEIN_ASSOCIATION: pyrroline-5-carboxylate reductase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.5.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10020005V04 PROTEIN_ASSOCIATION: pyrroline-5-carboxylate reductase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.5.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20210011V04 and SP20210012V04 PROTEIN_ASSOCIATION: delta-1-pyrroline-5-carboxylate dehydrogenase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.5.1.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20210011V04 and SP20210012V04 PROTEIN_ASSOCIATION: delta-1-pyrroline-5-carboxylate dehydrogenase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.5.99.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050003V04 PROTEIN_ASSOCIATION: glutamate N-acetyltransferase / amino-acid N-acetyltransferase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.3.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250140V04 PROTEIN_ASSOCIATION: N-acetylglutamate kinase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.7.2.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30170033V04 PROTEIN_ASSOCIATION: N-acetyl-gamma-glutamyl-phosphate reductase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.2.1.38 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140011V04 PROTEIN_ASSOCIATION: acetylornithine aminotransferase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.6.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050003V04 PROTEIN_ASSOCIATION: glutamate N-acetyltransferase / amino-acid N-acetyltransferase SUBSYSTEM: S_Arginine biosynthesis II (acetyl cycle) PROTEIN_CLASS: 2.3.1.35 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30030005V04 and SP50140032V04 PROTEIN_ASSOCIATION: carbamoyl-phosphate synthase small chain SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 6.3.5.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40020016V04 PROTEIN_ASSOCIATION: ornithine carbamoyltransferase chain f SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.1.3.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110155V04 PROTEIN_ASSOCIATION: argininosuccinate synthase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 6.3.4.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20180087V04 PROTEIN_ASSOCIATION: L-argininosuccinate lyase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 4.3.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030116V04 PROTEIN_ASSOCIATION: arginine decarboxylase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 4.1.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240023V04 PROTEIN_ASSOCIATION: agmatine ureohydrolase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 3.5.3.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: diamine transaminase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.6.1.29 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10100016V04 PROTEIN_ASSOCIATION: spermidine synthase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.5.1.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150037V04 PROTEIN_ASSOCIATION: adenosylmethionine decarboxylase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 4.1.1.50 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250080V04 PROTEIN_ASSOCIATION: aminobutyraldehyde dehydrogenase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.2.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: 4-aminobutyrate transaminase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.6.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060247V04 PROTEIN_ASSOCIATION: glutathionylspermidine amidase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 3.5.1.78 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060247V04 PROTEIN_ASSOCIATION: glutathionylspermidine synthase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 6.3.1.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350069V04 PROTEIN_ASSOCIATION: succinate-semialdehyde dehydrogenase (NADP+) SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.2.1.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350069V04 PROTEIN_ASSOCIATION: succinate-semialdehyde dehydrogenase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 1.2.1.24 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10330017V04 or SP70090150V04 PROTEIN_ASSOCIATION: L-threonine deaminase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 4.3.1.17 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110047V04 PROTEIN_ASSOCIATION: phosphoglycerate dehydrogenase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 1.1.1.95 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: phosphoserine aminotransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis --B6 PROTEIN_CLASS: 2.6.1.52 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20140011V04 PROTEIN_ASSOCIATION: phosphoserine phosphatase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 3.1.3.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350102V04 PROTEIN_ASSOCIATION: serine hydroxymethyltransferase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 2.1.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20150017V04 or SP30060027V04 PROTEIN_ASSOCIATION: serine acetyltransferase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 2.3.1.30 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20020013V04 or SP20150018V04 or SP60010008V04 PROTEIN_ASSOCIATION: cysteine synthase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 2.5.1.47 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40090026V04 PROTEIN_ASSOCIATION: sulfate adenylyltransferase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 2.7.7.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60150004V04 PROTEIN_ASSOCIATION: adenylylsulfate 3-phosphotransferase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 2.7.1.25 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40090019V04 PROTEIN_ASSOCIATION: phosphoadenosine phosphosulfate reductase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 1.8.4.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80040012V04 PROTEIN_ASSOCIATION: ferredoxin-sulfite reductase SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 1.8.7.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: hypSP20210020V04 PROTEIN_ASSOCIATION: glycerate kinase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 2.7.1.31 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70140087V04 PROTEIN_ASSOCIATION: homoserine kinase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 2.7.1.39 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140176V04 PROTEIN_ASSOCIATION: homoserine dehydrogenase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 1.1.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140133V04 or SP80050154V04 PROTEIN_ASSOCIATION: threonine synthase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 4.2.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10070022V04 PROTEIN_ASSOCIATION: aspartate beta-semialdehyde dehydrogenese SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 1.2.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10070023V04 PROTEIN_ASSOCIATION: dihydrodipicolinate synthase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 4.2.1.52 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30190006V04 PROTEIN_ASSOCIATION: aspartate kinase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 2.7.2.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090062V04 PROTEIN_ASSOCIATION: dihydrodipicolinate reductase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 1.3.1.26 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030040V04 and SP70030039V04 PROTEIN_ASSOCIATION: N-succinyldiaminopimelate aminotransferase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 2.6.1.17 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70010006V04 PROTEIN_ASSOCIATION: diaminopimelate epimerase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 5.1.1.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140142V04 or SP60070097V04 PROTEIN_ASSOCIATION: diaminopimelate decarboxylase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 4.1.1.20 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060099V04 PROTEIN_ASSOCIATION: lysine decarboxylase SUBSYSTEM: S_Threonine Lysine and Homoserine Metabolism PROTEIN_CLASS: 4.1.1.18 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40100009V04 PROTEIN_ASSOCIATION: phospho-2-dehydro-3-deoxyheptonate aldolase / chorismate mutase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 2.5.1.54 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: ( SP10450053V04 and SP10450054V04 ) or SP70180105V04 PROTEIN_ASSOCIATION: 3-dehydroquinate synthase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.2.3.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350107V04 PROTEIN_ASSOCIATION: carbonic 3-dehydroquinase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.2.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70180090V04 PROTEIN_ASSOCIATION: shikimate 5-dehydrogenase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 1.1.1.25 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440132V04 PROTEIN_ASSOCIATION: shikimate kinase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 2.7.1.71 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10200002V04 PROTEIN_ASSOCIATION: 3-phosphoshikimate 1-carboxyvinyltransferase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 2.5.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440113V04 PROTEIN_ASSOCIATION: chorismate synthase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.2.3.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140017V04 PROTEIN_ASSOCIATION: chorismate mutase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 5.4.99.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040124V04 or SP30060044V04 PROTEIN_ASSOCIATION: anthranilate synthase component II SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.1.3.27 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040124V04 or SP30060044V04 PROTEIN_ASSOCIATION: anthranilate synthase component II SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.1.3.27 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080071V04 PROTEIN_ASSOCIATION: prephenate dehydrogenase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 1.3.1.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190060V04 PROTEIN_ASSOCIATION: prephenate dehydratase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.2.1.51 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030038V04 PROTEIN_ASSOCIATION: aromatic-amino-acid transaminase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 2.6.1.57 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030038V04 PROTEIN_ASSOCIATION: aromatic-amino-acid transaminase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 2.6.1.57 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20010002V04 and SP20250139V04 PROTEIN_ASSOCIATION: tryptophan synthase beta chain SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.2.1.20 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090180V04 PROTEIN_ASSOCIATION: N-(5'-phosphoribosyl)anthranilate isomerase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 5.3.1.24 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030036V04 PROTEIN_ASSOCIATION: indole-3-glycerol phosphate synthase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 4.1.1.48 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050162V04 PROTEIN_ASSOCIATION: anthranilate phosphoribosyltransferase SUBSYSTEM: S_Tyrosine, Tryptophan, and Phenylalanine Metabolism PROTEIN_CLASS: 2.4.2.18 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: homoserine O-succinyltransferase SUBSYSTEM: S_Methionine Metabolism PROTEIN_CLASS: 2.3.1.46 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: cystathionine gamma-synthase SUBSYSTEM: S_Methionine Metabolism PROTEIN_CLASS: 2.5.1.48 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440013V04 PROTEIN_ASSOCIATION: cystathionine beta-lyase SUBSYSTEM: S_Methionine Metabolism PROTEIN_CLASS: 4.4.1.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10100015V04 PROTEIN_ASSOCIATION: 5-methyltetrahydrofolate-homocysteine methyltransferase SUBSYSTEM: S_Methionine Metabolism PROTEIN_CLASS: 2.1.1.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60030026V04 PROTEIN_ASSOCIATION: S-adenosylmethionine synthetase SUBSYSTEM: S_Methionine Metabolism PROTEIN_CLASS: 2.5.1.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250061V04 PROTEIN_ASSOCIATION: pantothenate kinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.1.33 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060020V04 PROTEIN_ASSOCIATION: phosphopantothenate-cysteine ligase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.2.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060020V04 PROTEIN_ASSOCIATION: phosphopantothenoylcysteine decarboxylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.1.36 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080008V04 PROTEIN_ASSOCIATION: pantetheine-phosphate adenylyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.7.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70180137V04 PROTEIN_ASSOCIATION: dephospho-CoA kinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.1.24 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30190012V04 or SP10190026V04 PROTEIN_ASSOCIATION: bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.1.1.107 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30190012V04 or SP10190026V04 PROTEIN_ASSOCIATION: bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.1.1.107 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30190012V04 or SP10190026V04 PROTEIN_ASSOCIATION: sirohydrochlorin dehydrogenase (NAD) SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30190012V04 or SP10190026V04 PROTEIN_ASSOCIATION: sirohydrochlorin ferrochetalase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10010013V04 or SP10110048V04 PROTEIN_ASSOCIATION: prepilin peptidase / N-methyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.1.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: 2-octaprenyl-6-hydroxyphenol methylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140053V04 or SP70090280V04 PROTEIN_ASSOCIATION: 8-amino-7-oxononanoate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.3.1.47 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030100V04 PROTEIN_ASSOCIATION: dethiobiotin synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.3.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: CT04270014V04 PROTEIN_ASSOCIATION: biotin synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.8.1.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140040V04 PROTEIN_ASSOCIATION: coproporphyrinogen III oxidase, aerobic (oxygen-dependent) SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.3.3.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80030021V04 PROTEIN_ASSOCIATION: uroporphyrinogen decarboxylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.1.37 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140093V04 PROTEIN_ASSOCIATION: protoporphyrinogen oxidase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.3.3.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140093V04 PROTEIN_ASSOCIATION: protoporphyrinogen oxidase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.3.3.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10150048V04 or SP20150008V04 PROTEIN_ASSOCIATION: ferrochelatase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.99.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40050025V04 or SP70040031V04 PROTEIN_ASSOCIATION: GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase (dhbp synthase) SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.5.4.25 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220018V04 PROTEIN_ASSOCIATION: diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.5.4.26 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220018V04 PROTEIN_ASSOCIATION: diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.1.1.193 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: pyrimidine phosphatase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30070013V04 or SP70060012V04 PROTEIN_ASSOCIATION: riboflavin synthase alpha chain SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30070013V04 or SP70060012V04 PROTEIN_ASSOCIATION: riboflavin synthase alpha chain SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.99.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040098V04 PROTEIN_ASSOCIATION: riboflavin kinase / FMN adenylyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.1.26 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040098V04 PROTEIN_ASSOCIATION: riboflavin kinase / FMN adenylyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.7.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080017V04 PROTEIN_ASSOCIATION: acid phosphatase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.1.3.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30180034V04 PROTEIN_ASSOCIATION: glutamyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.17 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090038V04 PROTEIN_ASSOCIATION: glutamyl-tRNA reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.2.1.70 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040046V04 PROTEIN_ASSOCIATION: glutamate-1-semialdehyde 2,1-aminomutase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 5.4.3.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30070033V04 PROTEIN_ASSOCIATION: porphobilinogen synthase (5-aminolevulinate dehydratase) SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.2.1.24 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10180001V04 PROTEIN_ASSOCIATION: porphobilinogen deaminase (hydroxymethylbilane synthase, preuroporphyrinogen synthase) SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.61 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190026V04 PROTEIN_ASSOCIATION: bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.2.1.75 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390042V04 or SP20110051V04 or SP50150035V04 PROTEIN_ASSOCIATION: GTP cyclohydrolase I SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.5.4.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30010011V04 PROTEIN_ASSOCIATION: 6-pyruvoyl-tetrahydropterin synthase SUBSYSTEM: S_Folate Metabolism PROTEIN_CLASS: 4.2.3.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210037V04 or SP10250008V04 or SP10290038V04 or SP10350133V04 or SP10440130V04 or SP20250179V04 or SP20250180V04 or SP30140125V04 or SP30150024V04 or SP70070016V04 or SP70180060V04 or SP80050076V04 or SP80050086V04 or SP80060008V04 PROTEIN_ASSOCIATION: cation-transporting p-type ATPase PacL SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.6.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210037V04 or SP10250008V04 or SP10290038V04 or SP10350133V04 or SP10440130V04 or SP20250179V04 or SP20250180V04 or SP30140125V04 or SP30150024V04 or SP70070016V04 or SP70180060V04 or SP80050076V04 or SP80050086V04 or SP80060008V04 PROTEIN_ASSOCIATION: cation-transporting p-type ATPase PacL SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.6.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060004V04 PROTEIN_ASSOCIATION: dihydroneopterin aldolase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.2.25 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10210036V04 PROTEIN_ASSOCIATION: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.6.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060044V04 PROTEIN_ASSOCIATION: aminodeoxychorismate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.6.1.85 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30170015V04 PROTEIN_ASSOCIATION: 4-aminobenzoate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.3.38 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150084V04 PROTEIN_ASSOCIATION: dihydropteroate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250144V04 PROTEIN_ASSOCIATION: folylpolyglutamate synthase / dihydrofolate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.2.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: dihydrofolate reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.5.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440136V04 PROTEIN_ASSOCIATION: 3-methyl-2-oxobutanoate hydroxymethyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.1.2.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170031V04 or SP20260010V04 PROTEIN_ASSOCIATION: 2-dehydropantoate 2-reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.1.1.169 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250113V04 PROTEIN_ASSOCIATION: pantoate-beta-alanine ligase / cytidylate kinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030004V04 or SP70010025V04 or CT01050001V04 PROTEIN_ASSOCIATION: probable 1-deoxyxylulose-5-phosphate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.2.1.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290047V04 PROTEIN_ASSOCIATION: 1-deoxy-D-xylulose 5-phosphate reductoisomerase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.1.1.267 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290047V04 PROTEIN_ASSOCIATION: 1-deoxy-D-xylulose 5-phosphate reductoisomerase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.1.1.267 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250077V04 PROTEIN_ASSOCIATION: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.7.60 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030045V04 PROTEIN_ASSOCIATION: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.1.148 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040009V04 PROTEIN_ASSOCIATION: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.6.1.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80010019V04 PROTEIN_ASSOCIATION: GcpE protein SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.17.4.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20020010V04 PROTEIN_ASSOCIATION: LytB protein homolog SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.17.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20020010V04 PROTEIN_ASSOCIATION: LytB protein homolog SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.17.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10070011V04 PROTEIN_ASSOCIATION: isopentenyl-diphosphate delta-isomerase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 5.3.3.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080023V04 PROTEIN_ASSOCIATION: dimethylallyltranstransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080023V04 PROTEIN_ASSOCIATION: geranyltranstransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140145V04 PROTEIN_ASSOCIATION: undecaprenyl pyrophosphate synthetase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.31 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20090005V04 or SP20170059V04 or SP20260019V04 or SP50110020V04 or SP60010083V04 or SP70080078V04 PROTEIN_ASSOCIATION: 4-hydroxybenzoate-octaprenyl transferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440135V04 or SP60010044V04 PROTEIN_ASSOCIATION: hypothetical protein SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: 2-Octaprenylphenol hydroxylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: phosphomethylpyrimidine kinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.4.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20260010V04 PROTEIN_ASSOCIATION: Thiamine biosynthesis protein SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis -B1 PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60030025V04 and SP10090025V04 PROTEIN_ASSOCIATION: thiazole synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis -B1 PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150096V04 PROTEIN_ASSOCIATION: thiamin-phosphate pyrophosphorylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis -B1 PROTEIN_CLASS: 2.5.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170052V04 PROTEIN_ASSOCIATION: putative thiamine-monophosphate kinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.4.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20210017V04 PROTEIN_ASSOCIATION: 2-oxoglutarate decarboxylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.1.71 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20210017V04 PROTEIN_ASSOCIATION: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.2.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170053V04 or SP20170054V04 PROTEIN_ASSOCIATION: isochorismate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 5.4.4.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10070027V04 PROTEIN_ASSOCIATION: O-succinylbenzoate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.2.1.113 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240008V04 PROTEIN_ASSOCIATION: O-succinylbenzoic acid-CoA ligase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.2.1.26 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250118V04 PROTEIN_ASSOCIATION: 1,4-dihydroxy-2-naphthoate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.3.36 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20090005V04 or SP20170059V04 or SP20260019V04 or SP50110020V04 or SP60010083V04 or SP70080078V04 PROTEIN_ASSOCIATION: 4-hydroxybenzoate-octaprenyl transferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: hypSP20170029V04 PROTEIN_ASSOCIATION: chorismate lyase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.3.40 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060241V04 PROTEIN_ASSOCIATION: L-aspartate oxidase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.4.3.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380058V04 PROTEIN_ASSOCIATION: quinolinate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 4.1.99.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090080V04 PROTEIN_ASSOCIATION: nicotinate-nucleotide pyrophosphorylase (carboxylating) SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.4.2.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150004V04 PROTEIN_ASSOCIATION: nicotinate phosphoribosyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.4.2.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: hypSP30140075V04 PROTEIN_ASSOCIATION: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.4.2.21 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20180101V04 PROTEIN_ASSOCIATION: alpha-ribazole phosphatase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.1.3.73 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140032V04 or SP30030017V04 PROTEIN_ASSOCIATION: NADPH-dependent FMN reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140032V04 or SP30030017V04 PROTEIN_ASSOCIATION: NADPH-dependent FMN reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140032V04 or SP30030017V04 PROTEIN_ASSOCIATION: NADPH-dependent FMN reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.5.1.30 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140032V04 or SP30030017V04 PROTEIN_ASSOCIATION: NADPH-dependent FMN reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.5.1.30 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140032V04 or SP30030017V04 PROTEIN_ASSOCIATION: NADPH-dependent FMN reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10090058V04 PROTEIN_ASSOCIATION: glutathione-disulfide reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.8.1.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: hypSP20230009V04 PROTEIN_ASSOCIATION: glutamate-cysteine ligase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.2.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20180129V04 PROTEIN_ASSOCIATION: glutathione synthetase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.2.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140032V04 or SP30030017V04 PROTEIN_ASSOCIATION: NADPH-dependent FMN reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.5.1.29 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60140032V04 or SP30030017V04 PROTEIN_ASSOCIATION: NADPH-dependent FMN reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.5.1.29 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60170003V04 PROTEIN_ASSOCIATION: guanosine-5'-triphosphate,3'-diphosphate diphosphatase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.6.1.40 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30120025V04 or SP30140100V04 PROTEIN_ASSOCIATION: GTP diphosphokinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.6.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30120025V04 or SP30140100V04 PROTEIN_ASSOCIATION: GTP diphosphokinase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.6.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140100V04 PROTEIN_ASSOCIATION: (p)ppGpp 3-pyrophosphohydrolase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 3.1.7.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20200027V04 or SP20250187V04 PROTEIN_ASSOCIATION: probable inorganic polyphosphate/ATP-NAD kinase 1 SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.1.23 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010175V04 or SP60040015V04 PROTEIN_ASSOCIATION: beta-carotene hydroxylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010175V04 or SP60040015V04 or CT04270017V04 PROTEIN_ASSOCIATION: beta-carotene hydroxylase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.14.13.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30050028V04 PROTEIN_ASSOCIATION: NH(3)-dependent NAD(+) synthetase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.5.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20020004V04 PROTEIN_ASSOCIATION: lactoylglutathione lyase SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 4.4.1.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350014V04 or SP20040131V04 PROTEIN_ASSOCIATION: hypothetical protein SUBSYSTEM: S_Pyruvate Metabolism PROTEIN_CLASS: 3.1.2.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080024V04 PROTEIN_ASSOCIATION: methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase SUBSYSTEM: S_Folate Metabolism PROTEIN_CLASS: 1.5.1.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080024V04 PROTEIN_ASSOCIATION: methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase SUBSYSTEM: S_Folate Metabolism PROTEIN_CLASS: 3.5.4.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40090097V04 PROTEIN_ASSOCIATION: formyltetrahydrofolate deformylase SUBSYSTEM: S_Folate Metabolism PROTEIN_CLASS: 3.5.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70060030V04 PROTEIN_ASSOCIATION: glycine cleavage system protein H SUBSYSTEM: S_Folate Metabolism PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10330013V04 PROTEIN_ASSOCIATION: methylenetetrahydrofolate reductase (NADPH) SUBSYSTEM: S_Folate Metabolism PROTEIN_CLASS: 1.5.1.20 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10330013V04 PROTEIN_ASSOCIATION: methylenetetrahydrofolate reductase NADPH) SUBSYSTEM: S_Folate Metabolism PROTEIN_CLASS: 1.5.1.20 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30180067V04 PROTEIN_ASSOCIATION: cyanate lyase SUBSYSTEM: S_Nitrogen Metabolism PROTEIN_CLASS: 4.2.1.104 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30180067V04 PROTEIN_ASSOCIATION: cyanate lyase SUBSYSTEM: S_Nitrogen Metabolism PROTEIN_CLASS: 4.2.1.104 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140114V04 PROTEIN_ASSOCIATION: adenine phosphoribosyltransferase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.4.2.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50010016V04 or SP60150005V04 or SP70180097V04 or SP80010051V04 or SP10170015V04 PROTEIN_ASSOCIATION: amidotransferase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.4.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50010016V04 or SP60150005V04 or SP70180097V04 or SP80010051V04 or SP10170015V04 PROTEIN_ASSOCIATION: purine-nucleoside phosphorylase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.4.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140114V04 PROTEIN_ASSOCIATION: adenine phosphoribosyltransferase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.4.2.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70180046V04 PROTEIN_ASSOCIATION: dUTP diphosphatase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 3.6.1.23 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250113V04 PROTEIN_ASSOCIATION: pantoate-beta-alanine ligase / cytidylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250113V04 PROTEIN_ASSOCIATION: pantoate-beta-alanine ligase / cytidylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240033V04 or SP20250113V04 PROTEIN_ASSOCIATION: pantoate-beta-alanine ligase / cytidylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240033V04 PROTEIN_ASSOCIATION: pantoate-beta-alanine ligase / cytidylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: CT10640011V04 PROTEIN_ASSOCIATION: adenosine deaminase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 3.5.4.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70180047V04 PROTEIN_ASSOCIATION: thymidylate synthase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.1.1.45 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150020V04 PROTEIN_ASSOCIATION: thymidylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030098V04 PROTEIN_ASSOCIATION: ribose-phosphate pyrophosphokinase SUBSYSTEM: S_Histidine Metabolism PROTEIN_CLASS: 2.7.6.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70050072V04 PROTEIN_ASSOCIATION: (deoxy)adenylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350035V04 and SP10350036V04 and SP10350037V04 and SP10350039V04 and SP10350041V04 PROTEIN_ASSOCIATION: ribonucleoside-diphosphate reductase beta chain SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 1.17.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350035V04 and SP10350036V04 and SP10350037V04 and SP10350039V04 and SP10350041V04 PROTEIN_ASSOCIATION: ribonucleoside-diphosphate reductase beta chain SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 1.17.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350035V04 and SP10350036V04 and SP10350037V04 and SP10350039V04 and SP10350041V04 PROTEIN_ASSOCIATION: ribonucleoside-diphosphate reductase beta chain SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 1.17.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350035V04 and SP10350036V04 and SP10350037V04 and SP10350039V04 and SP10350041V04 PROTEIN_ASSOCIATION: ribonucleoside-diphosphate reductase beta chain SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 1.17.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70050072V04 PROTEIN_ASSOCIATION: adentylate kinase (GTP) SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100018V04 PROTEIN_ASSOCIATION: nucleoside diphosphate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70050072V04 PROTEIN_ASSOCIATION: adenylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70050072V04 PROTEIN_ASSOCIATION: adenosine kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.1.20 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060082V04 PROTEIN_ASSOCIATION: Uridine kinase-like protein SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.1.48 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440060V04 PROTEIN_ASSOCIATION: guanylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440060V04 PROTEIN_ASSOCIATION: guanylate kinase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.4.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110077V04 PROTEIN_ASSOCIATION: nicotinate-nucleotide adenylyltransferase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.7.7.18 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390012V04 PROTEIN_ASSOCIATION: guanine deaminase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 3.5.4.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110138V04 or SP20200026V04 or SP70180124V04 or SP80050187V04 or SP80050185V04 or SP80050185V04 or SP10310020V04 or SP20070010V04 PROTEIN_ASSOCIATION: adenylate cyclase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 4.6.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110138V04 or SP20200026V04 or SP70180124V04 or SP80050187V04 or SP80050185V04 or SP80050185V04 or SP10310020V04 or SP20070010V04 PROTEIN_ASSOCIATION: adenylate cyclase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 4.6.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10070010V04 or SP30150052V04 PROTEIN_ASSOCIATION: pyrimidine operon regulatory protein PyrR SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 2.4.2.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30150031V04 or SP80050182V04 PROTEIN_ASSOCIATION: cytosine deaminase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: 3.5.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: dCTP Deaminase SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50090003V04 PROTEIN_ASSOCIATION: Anaerobic ribonucleoside-triphosphate reductase activating protein SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50090003V04 PROTEIN_ASSOCIATION: Anaerobic ribonucleoside-triphosphate reductase activating protein SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50090003V04 PROTEIN_ASSOCIATION: Anaerobic ribonucleoside-triphosphate reductase activating protein SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50090003V04 PROTEIN_ASSOCIATION: Anaerobic ribonucleoside-triphosphate reductase activating protein SUBSYSTEM: S_Nucleotide Salvage Pathway PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040036V04 PROTEIN_ASSOCIATION: aspartate carbamoyltransferase catalytic chain SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 2.1.3.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350090V04 or SP20180100V04 PROTEIN_ASSOCIATION: dihydroorotase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 3.5.2.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10260028V04 PROTEIN_ASSOCIATION: dihydroorotate oxidase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 1.3.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80010015V04 or SP80060073V04 PROTEIN_ASSOCIATION: orotate phosphoribosyltransferase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 2.4.2.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060073V04 or SP40080004V04 PROTEIN_ASSOCIATION: orotidine 5'-phosphate decarboxylase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 4.1.1.23 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380009V04 PROTEIN_ASSOCIATION: CTP synthase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.4.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380009V04 PROTEIN_ASSOCIATION: CTP synthase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.4.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30100008V04 PROTEIN_ASSOCIATION: adenylosuccinate lyase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 4.3.2.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60020005V04 PROTEIN_ASSOCIATION: adenylosuccinate synthetase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.4.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30100008V04 PROTEIN_ASSOCIATION: adenylosuccinate lyase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 4.3.2.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350074V04 PROTEIN_ASSOCIATION: GMP synthase (glutamine-hydrolysing) SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.5.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040069V04 PROTEIN_ASSOCIATION: IMP dehydrogenase subunit SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 1.1.1.205 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70050016V04 PROTEIN_ASSOCIATION: phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 2.1.2.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70050016V04 PROTEIN_ASSOCIATION: phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 3.5.4.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110009V04 PROTEIN_ASSOCIATION: phosphoribosylamine-glycine ligase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.4.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30050002V04 or SP70090263V04 PROTEIN_ASSOCIATION: phosphoribosyl formylglycinamidine synthase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.5.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60070111V04 PROTEIN_ASSOCIATION: phosphoribosylglycinamide formyltransferase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 2.1.2.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250116V04 PROTEIN_ASSOCIATION: phosphoribosyl formylglycinamidine cyclo-ligase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30050005V04 PROTEIN_ASSOCIATION: amidophosphoribosyltransferase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 2.4.2.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60160005V04 PROTEIN_ASSOCIATION: phosphoribosyl aminoidazole succinocarboxamide synthetase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 6.3.2.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80030034V04 and SP30070041V04 PROTEIN_ASSOCIATION: phosphoribosylaminoimidazole carboxylase ATPase subunit SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 4.1.1.21 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110074V04 or SP20110074V04 PROTEIN_ASSOCIATION: ADP-ribose diphosphatase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 3.6.1.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60070111V04 PROTEIN_ASSOCIATION: phosphoribosylglycinamide formyltransferase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80030034V04 and SP30070041V04 PROTEIN_ASSOCIATION: phosphoribosylaminoimidazole carboxylase ATPase subunit SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80030034V04 and SP30070041V04 PROTEIN_ASSOCIATION: phosphoribosylaminoimidazole carboxylase ATPase subunit SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350074V04 PROTEIN_ASSOCIATION: GMP synthase (glutamine-hydrolysing) SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10450048V04 PROTEIN_ASSOCIATION: Dihydroorotate oxidase SUBSYSTEM: S_Purine and Pyrimidine Biosynthesis PROTEIN_CLASS: 1.3.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40010026V04 PROTEIN_ASSOCIATION: glucose-1-phosphate thymidylyltransferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.7.7.24 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50040013V04 or SP50150108V04 PROTEIN_ASSOCIATION: dTDP-glucose 4,6-dehydratase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 4.2.1.46 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40010024V04 or SP60120006V04 PROTEIN_ASSOCIATION: dTDP-4-dehydrorhamnose 3,5-epimerase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 5.1.3.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40010025V04 PROTEIN_ASSOCIATION: dTDP-6-deoxy-L-mannose-dehydrogenase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 1.1.1.133 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20200033V04 PROTEIN_ASSOCIATION: UDP-N-acetylglucosamine 1-carboxyvinyltransferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.5.1.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170048V04 PROTEIN_ASSOCIATION: UDP-N-acetylmuramate dehydrogenase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 1.1.1.158 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170048V04 PROTEIN_ASSOCIATION: UDP-N-acetylmuramate dehydrogenase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 1.1.1.158 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170049V04 PROTEIN_ASSOCIATION: UDP-N-acetylmuramate-alanine ligase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 6.3.2.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010106V04 PROTEIN_ASSOCIATION: glutamate racemase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 5.1.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040063V04 PROTEIN_ASSOCIATION: UDP-N-acetylmuramoylalanine-D-glutamate ligase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 6.3.2.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150119V04 PROTEIN_ASSOCIATION: UDP-MurNac-tripeptide synthetase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 6.3.2.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050020V04 PROTEIN_ASSOCIATION: D-alanine-D-alanine ligase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 6.3.2.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20180038V04 PROTEIN_ASSOCIATION: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 6.3.2.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80030030V04 PROTEIN_ASSOCIATION: phospho-N-acetylmuramoyl-pentapeptide-transferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.7.8.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50010008V04 PROTEIN_ASSOCIATION: UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.4.1.227 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040029V04 PROTEIN_ASSOCIATION: UDP-N-acetylglucosamine 2-epimerase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 5.1.3.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030046V04 or SP10030138V04 or SP10110138V04 or SP20090039V04 or SP20200011V04 or SP30140055V04 or SP60100021V04 or SP60150009V04 or SP70090082V04 or SP70090091V04 PROTEIN_ASSOCIATION: undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.4.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140052V04 or SP70060007V04 PROTEIN_ASSOCIATION: UDP-N-acetyl-D-mannosamine oxidoreductase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 1.1.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030040V04 and SP70030039V04 PROTEIN_ASSOCIATION: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.6.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030095V04 or SP10110139V04 or SP10120004V04 PROTEIN_ASSOCIATION: hemolysin activation protein SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.3.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030118V04 PROTEIN_ASSOCIATION: UTP-glucose-1-phosphate uridylyltransferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.7.7.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50040012V04 PROTEIN_ASSOCIATION: UDP-glucose dehydrogenase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 1.1.1.22 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010119V04 PROTEIN_ASSOCIATION: glucosamine-fructose-6-phosphate aminotransferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.6.1.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110136V04 PROTEIN_ASSOCIATION: Phosphoglucomutase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 5.4.2.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10150061V04 PROTEIN_ASSOCIATION: UDP-N-acetylglucosamine pyrophosphorylase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.3.1.157 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10150061V04 PROTEIN_ASSOCIATION: UDP-N-acetylglucosamine pyrophosphorylase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.7.7.23 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010029V04 PROTEIN_ASSOCIATION: mannose-1-phosphate guanylyltransferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.7.7.22 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60150041V04 or SP30120085V04 PROTEIN_ASSOCIATION: mannose-1-phosphate guanyltransferase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.7.7.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140053V04 or CT05370001V04 PROTEIN_ASSOCIATION: GDP-D-mannose dehydratase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 4.2.1.47 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: 3-beta hydroxysteroid dehydrogenase/isomerase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 1.1.1.271 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70080018V04 PROTEIN_ASSOCIATION: monophosphatase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 3.1.3.25 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140084V04 PROTEIN_ASSOCIATION: inositol-3-phosphate synthase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 5.5.1.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50070008V04 PROTEIN_ASSOCIATION: sucrose synthase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.4.1.13 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250132V04 PROTEIN_ASSOCIATION: ribulose-5-phosphate 4-epimerase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 5.1.3.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110115V04 or SP20110118V04 PROTEIN_ASSOCIATION: glycerol-3-phosphate dehydrogenase (NAD(P)+) SUBSYSTEM: S_Membrane Lipid Metabolism (phospholipid biosynthesis) PROTEIN_CLASS: 1.1.1.94 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090013V04 PROTEIN_ASSOCIATION: glycerol-3-phosphate dehydrogenase SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 1.1.99.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40040002V04 PROTEIN_ASSOCIATION: glycerol kinase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.1.30 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40010031V04 PROTEIN_ASSOCIATION: glycerol dehydrogenase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 1.1.1.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080066V04 PROTEIN_ASSOCIATION: fructokinase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.1.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10150033V04 PROTEIN_ASSOCIATION: 6-phosphogluconolactonase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 3.1.1.31 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190044V04 or SP80050093V04 PROTEIN_ASSOCIATION: mannose-6-phosphate isomerase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 5.3.1.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110053V04 or SP30120085V04 PROTEIN_ASSOCIATION: phosphomannomutase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 5.4.2.8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080066V04 or SP50140027V04 or SP60020003V04 PROTEIN_ASSOCIATION: ribokinase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.1.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30070044V04 PROTEIN_ASSOCIATION: N-acetyl-glucosamine-6-phosphate SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 3.5.1.25 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110015V04 or SP30090013V04 PROTEIN_ASSOCIATION: phosphofructokinase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050118V04 PROTEIN_ASSOCIATION: aldehyde dehydrogenase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 1.2.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110005V04 or SP40090039V04 PROTEIN_ASSOCIATION: phosphopentomutase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 5.4.2.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030119V04 or SP80060092V04 or SP80060093V04 PROTEIN_ASSOCIATION: 4-alpha-glucanotransferase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.4.1.25 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: trehalose-phosphatase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 3.1.3.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110119V04 PROTEIN_ASSOCIATION: alpha-alpha-trehalose-phosphate synthase (UDP-forming) SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.4.1.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110005V04 or SP40090039V04 PROTEIN_ASSOCIATION: phosphoglucomutase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 5.4.2.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010051V04 PROTEIN_ASSOCIATION: UDP-glucose-hexose-1-phosphate uridylyltransferase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.7.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390090V04 or SP30060050V04 or SP30150039V04 PROTEIN_ASSOCIATION: UDP-glucose 4-epimerase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 5.1.3.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30190016V04 or SP50010030V04 or SP60070120V04 PROTEIN_ASSOCIATION: phosphoglycolate phosphatase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 3.1.3.18 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050160V04 PROTEIN_ASSOCIATION: glycolate oxidase subunit GlcD SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 1.1.3.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030039V04 PROTEIN_ASSOCIATION: serine-glyoxylate transaminase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 2.6.1.45 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250192V04 or SP60120003V04 PROTEIN_ASSOCIATION: alpha-D-glucose-1-phosphate cytidylyltransferase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 2.7.7.33 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60120004V04 PROTEIN_ASSOCIATION: CDP-glucose 4,6-dehydratase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 4.2.1.45 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290026V04 and SP50050009V04 PROTEIN_ASSOCIATION: acyl-acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase SUBSYSTEM: S_Lipopolysaccharide Biosynthesis / Recycling PROTEIN_CLASS: 2.3.1.129 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: UDP-3-O-acyl-N-acetylglucosamine deacetylase SUBSYSTEM: S_ PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: UDP-3-O-[3-hydroxymyristoyl]glucosamine N-acetyltransferase SUBSYSTEM: S_ PROTEIN_CLASS: 2.3.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290028V04 PROTEIN_ASSOCIATION: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase SUBSYSTEM: S_Lipopolysaccharide Biosynthesis / Recycling PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290025V04 or SP80050026V04 PROTEIN_ASSOCIATION: lipid A disaccharide synthase SUBSYSTEM: S_Lipopolysaccharide Biosynthesis / Recycling PROTEIN_CLASS: 2.4.1.182 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110048V04 and SP50150125V04 and SP50130016V04 and SP10190019V04 PROTEIN_ASSOCIATION: acetyl-CoA carboxylase subunit SUBSYSTEM: S_Membrane Lipid Metabolism fatty acid biosynthesis) PROTEIN_CLASS: 6.4.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080007V04 PROTEIN_ASSOCIATION: malonyl CoA-acyl carrier protein transacylase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.39 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080008V04 or SP30200034V04 or SP70090272V04 or SP70090277V04 or SP60010108V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 or SP70090272V04 or SP70090277V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 or SP70090272V04 or SP70090277V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 or SP70090272V04 or SP70090277V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 or SP70090272V04 or SP70090277V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 or SP70090272V04 or SP70090277V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 or SP70090272V04 or SP70090277V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 or SP70090272V04 or SP70090277V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier-protein] synthase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 2.3.1.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440081V04 or SP20090028V04 PROTEIN_ASSOCIATION: 3-oxoacyl-[acyl-carrier protein] reductase 2 SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.1.1.100 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: crotonoyl-[acyl-carrier-protein] hydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.58 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: crotonoyl-[acyl-carrier-protein] hydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.58 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: crotonoyl-[acyl-carrier-protein] hydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.58 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.60 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: 3- hydroxypalmitoyl-[acyl-carrier-protein] dehydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.61 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: 3- hydroxypalmitoyl-[acyl-carrier-protein] dehydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.61 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: 3- hydroxypalmitoyl-[acyl-carrier-protein] dehydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.61 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290027V04 PROTEIN_ASSOCIATION: 3- hydroxypalmitoyl-[acyl-carrier-protein] dehydratase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 4.2.1.61 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220040V04 PROTEIN_ASSOCIATION: enoyl-[acyl-carrier-protein] reductase (NADPH, B- specific) SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030095V04 or SP10110139V04 or SP10120004V04 PROTEIN_ASSOCIATION: hemolysin activation protein SUBSYSTEM: S_Membrane Lipid Metabolism PROTEIN_CLASS: 2.3.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200034V04 or SP60010108V04 PROTEIN_ASSOCIATION: malonyl coenzyme A-acyl carrier protein transacylase SUBSYSTEM: S_Membrane Lipid Metabolism PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10090016V04 PROTEIN_ASSOCIATION: acetyl coenzyme A acetyltransferase SUBSYSTEM: S_Membrane Lipid Metabolism PROTEIN_CLASS: 2.3.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350064V04 PROTEIN_ASSOCIATION: putative thioredoxin reductase SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 1.8.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150008V04 or SP20250101V04 PROTEIN_ASSOCIATION: succinate dehydrogenase iron-sulfur protein SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 1.3.99.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150008V04 or SP20250101V04 PROTEIN_ASSOCIATION: succinate dehydrogenase iron-sulfur protein SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 1.3.99.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040075V04 or SP10260019V04 or SP10260021V04 or SP10260023V04 or SP10260024V04 or SP20110132V04 or SP20250005V04 or SP30190030V04 or SP50040010V04 or SP70090155V04 or SP70090158V04 or SP80050146V04 or SP80050147V04 or SP10040077V04 or SP20110135V04 or SP60140040V04 or SP50040009V04 or SP50040011V04 PROTEIN_ASSOCIATION: NADH dehydrogenase I chain H SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 1.6.5.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30110024V04 or SP60010132V04 or SP80050160V04 PROTEIN_ASSOCIATION: D-lactate dehydrogenase (cytochrome) SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 1.1.2.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200027V04 PROTEIN_ASSOCIATION: polyphosphate kinase SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 2.7.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200027V04 PROTEIN_ASSOCIATION: polyphosphate kinase SUBSYSTEM: S_Oxidative Phosphorylation PROTEIN_CLASS: 2.7.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350124V04 PROTEIN_ASSOCIATION: alanyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080013V04 and SP20080014V04 and SP20080030V04 and SP20080031V04 PROTEIN_ASSOCIATION: phenylalanyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.20 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10450101V04 or SP10450102V04 or SP50070013V04 PROTEIN_ASSOCIATION: lysyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250036V04 and SP80070005V04 PROTEIN_ASSOCIATION: glycyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350031V04 PROTEIN_ASSOCIATION: isoleucyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30050021V04 PROTEIN_ASSOCIATION: prolyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30070029V04 PROTEIN_ASSOCIATION: cysteinyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350118V04 PROTEIN_ASSOCIATION: leucyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10290004V04 PROTEIN_ASSOCIATION: Glutamyl-tRNA(Gln) amidotransferase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.3.5.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090123V04 PROTEIN_ASSOCIATION: seryl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80110009V04 PROTEIN_ASSOCIATION: asparaginyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.22 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080005V04 PROTEIN_ASSOCIATION: tyrosyl tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20050003V04 or CT05700001V04 PROTEIN_ASSOCIATION: threonyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030151V04 or SP80050183V04 PROTEIN_ASSOCIATION: aspartyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.12 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50040020V04 or SP80110006V04 PROTEIN_ASSOCIATION: arginyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150071V04 PROTEIN_ASSOCIATION: methionyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080062V04 PROTEIN_ASSOCIATION: histidyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.21 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140108V04 PROTEIN_ASSOCIATION: methionyl-tRNA formyltransferase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 2.1.2.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10330014V04 PROTEIN_ASSOCIATION: tryptophanyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090040V04 PROTEIN_ASSOCIATION: valyl-tRNA synthetase SUBSYSTEM: S_tRNA Charging PROTEIN_CLASS: 6.1.1.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10170007V04 PROTEIN_ASSOCIATION: superoxide dismutase SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 1.15.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20230014V04 PROTEIN_ASSOCIATION: glutathion-dependent peroxidase, type II peroxiredoxin SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 1.11.1.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090140V04 PROTEIN_ASSOCIATION: selenide water dikinase SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 2.7.9.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040069V04 PROTEIN_ASSOCIATION: periplasmic beta-type carbonic anhydrase SUBSYSTEM: S_HCO3 equilibration reaction PROTEIN_CLASS: 4.2.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040069V04 PROTEIN_ASSOCIATION: periplasmic beta-type carbonic anhydrase SUBSYSTEM: S_HCO3 equilibration reaction PROTEIN_CLASS: 4.2.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: 4-hydroxyphenylacetate 3-monooxygenase SUBSYSTEM: S_4-hydroxyphenylacetate degradation PROTEIN_CLASS: 1.14.14.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: 3,4-dihydroxyphenylacetate 2,3-dioxygenase SUBSYSTEM: S_4-hydroxyphenylacetate degradation PROTEIN_CLASS: 1.13.11.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase SUBSYSTEM: S_4-hydroxyphenylacetate degradation PROTEIN_CLASS: 1.2.1.60 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350071V04 PROTEIN_ASSOCIATION: 5-carboxymethyl-2-hydroxymuconate D-isomerase SUBSYSTEM: S_4-hydroxyphenylacetate degradation PROTEIN_CLASS: 5.3.3.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase SUBSYSTEM: S_4-hydroxyphenylacetate degradation PROTEIN_CLASS: 4.1.1.68 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: probable O-succinylbenzoic acid synthase SUBSYSTEM: S_4-hydroxyphenylacetate degradation PROTEIN_CLASS: 4.2.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390095V04 PROTEIN_ASSOCIATION: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase SUBSYSTEM: S_4-hydroxyphenylacetate degradation PROTEIN_CLASS: 4.1.2.20 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40110047V04 PROTEIN_ASSOCIATION: formamidase SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 3.5.1.49 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170032V04 PROTEIN_ASSOCIATION: fatty-acid-CoA thioesterase SUBSYSTEM: S_Membrane Lipid Metabolism PROTEIN_CLASS: 3.1.2.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390031V04 PROTEIN_ASSOCIATION: long-chain-fatty-acid CoA ligase SUBSYSTEM: S_Membrane Lipid Metabolism PROTEIN_CLASS: 6.2.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60020011V04 PROTEIN_ASSOCIATION: acyl-CoA dehydrogenase SUBSYSTEM: S_Membrane Lipid Metabolism PROTEIN_CLASS: 1.3.99.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030125V04 PROTEIN_ASSOCIATION: sirohydrochlorin cobaltochelatase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 4.99.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040053V04 PROTEIN_ASSOCIATION: S-adenosyl-methionine:precorrin-2 methyltransferase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.151 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040054V04 PROTEIN_ASSOCIATION: Precorrin-3B C17-methyltransferase (Precorrin-3 methyltransferase) (Precorrin-3 methylase, necessary for ring contraction in the conversion from precorrin-3B to precorrin-4 SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.131 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220059V04 PROTEIN_ASSOCIATION: precorrin-4 C11-methyltransferase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.133 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040054V04 PROTEIN_ASSOCIATION: Precorrin-3B C17-methyltransferase (Precorrin-3 methyltransferase) (Precorrin-3 methylase, necessary for ring contraction in the conversion from precorrin-3B to precorrin-4 SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.131 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10010013V04 or SP10110048V04 PROTEIN_ASSOCIATION: prepilin peptidase / N-methyltransferase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040047V04 PROTEIN_ASSOCIATION: precorrin-6X reductase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 1.3.1.54 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040049V04 or SP80060098V04 or SP30140153V04 PROTEIN_ASSOCIATION: precorrin-6y C5, 15-methyltransferase (decarboxylating) SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.132 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040049V04 or SP80060098V04 or SP30140153V04 PROTEIN_ASSOCIATION: precorrin-6y C5, 15-methyltransferase (decarboxylating) SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.132 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040052V04 or SP70090058V04 PROTEIN_ASSOCIATION: cobalt-dependent transcriptional regulator CoaR or CorR (MerR (mercuric resistance operon regulatory protein)-like domain in N-terminal half and a domain of precorrin isomerase, Precorrin-8X methylmutase in C-terminal half) SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 5.4.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60170016V04 or SP30110035V04 PROTEIN_ASSOCIATION: hydrogenobyrinic acid a,c-diamide synthase (glutamine -hydrolysing) SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 6.3.5.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: cob(II)yrinic acid a,c-diamide reductase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 1.16.8.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30190012V04 or SP10190026V04 PROTEIN_ASSOCIATION: bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.107 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70080049V04 PROTEIN_ASSOCIATION: cobyric acid synthase SUBSYSTEM: S_Adenosylcobalamin biosynthesis I (early cobalt incorporation) -B12 PROTEIN_CLASS: 6.3.5.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10070007V04 or SP50150010V04 PROTEIN_ASSOCIATION: cobalamin biosynthesis protein SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 6.3.1.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10070007V04 or SP50150010V04 PROTEIN_ASSOCIATION: Bifunctional cobalamin biosynthesis protein catalyzing both reactions of cobinamide kinase and cobinamide phosphate guanylyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.7.62 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010022V04 PROTEIN_ASSOCIATION: cobalamin (5'-phosphate) synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.7.8.26 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060063V04 PROTEIN_ASSOCIATION: cob(I)alamin adenosyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.17 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040053V04 PROTEIN_ASSOCIATION: precorrin-2 C20-methyltransferase SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.130 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: precorrin-3B synthase SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 1.14.13.83 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040054V04 PROTEIN_ASSOCIATION: Precorrin-3B C17-methyltransferase (Precorrin-3 methyltransferase) (Precorrin-3 methylase, necessary for ring contraction in the conversion from precorrin-3B to precorrin-4 SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.131 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20220059V04 PROTEIN_ASSOCIATION: precorrin-4 C11-methyltransferase SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.133 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040053V04 PROTEIN_ASSOCIATION: precorrin-2 C20-methyltransferase SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.130 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040047V04 PROTEIN_ASSOCIATION: precorrin-6X reductase SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 1.3.1.54 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040049V04 or SP80060098V04 or SP30140153V04 PROTEIN_ASSOCIATION: precorrin-6y C5, 15-methyltransferase (decarboxylating) SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 2.1.1.132 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040052V04 or SP70090058V04 PROTEIN_ASSOCIATION: cobalt-dependent transcriptional regulator CoaR or CorR (MerR (mercuric resistance operon regulatory protein)-like domain in N-terminal half and a domain of precorrin isomerase, Precorrin-8X methylmutase in C-terminal half) SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 5.4.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60170016V04 or SP30110035V04 PROTEIN_ASSOCIATION: hydrogenobyrinic acid a,c-diamide synthase (glutamine -hydrolysing) SUBSYSTEM: S_Adenosyl biosynthesis II (late cobalt incorporation) -B12 PROTEIN_CLASS: 6.3.5.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50110015V04 or SP50110016V04 or SP50110018V04 PROTEIN_ASSOCIATION: cytochrome c oxidase subunit II SUBSYSTEM: S_Aerobic respiration - electron donor II PROTEIN_CLASS: 1.9.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60150023V04 or SP60150026V04 or SP60150027V04 PROTEIN_ASSOCIATION: cytochrome bd-type quinol oxidase subunit II SUBSYSTEM: S_Aerobic respiration - electron donor II PROTEIN_CLASS: 1.10.3.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240023V04 PROTEIN_ASSOCIATION: arginase/agmatinase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 3.5.3.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30030018V04 PROTEIN_ASSOCIATION: arsenate reductase SUBSYSTEM: S_arsenate detoxification II PROTEIN_CLASS: 1.20.4.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150075V04 PROTEIN_ASSOCIATION: phosphoribulokinase SUBSYSTEM: S_Calvin cycle PROTEIN_CLASS: 2.7.1.19 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110007V04 or SP10110010V04 or SP70090053V04 PROTEIN_ASSOCIATION: ribulose 1,5-bisphosphate carboxylase/oxygenase small subunit SUBSYSTEM: S_Calvin cycle PROTEIN_CLASS: 4.1.1.39 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090036V04 PROTEIN_ASSOCIATION: fructose-1,6-/sedoheptulose-1,7-bisphosphatase SUBSYSTEM: S_Calvin cycle PROTEIN_CLASS: 3.1.3.37 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080023V04 PROTEIN_ASSOCIATION: geranylgeranyl diphosphate synthase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 2.5.1.29 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20180060V04 PROTEIN_ASSOCIATION: phytoene synthase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 2.5.1.32 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20180060V04 PROTEIN_ASSOCIATION: phytoene synthase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 2.5.1.32 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10250033V04 or SP80050158V04 PROTEIN_ASSOCIATION: acyl-lipid desaturase (delta 12) SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.99.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10250033V04 or SP80050158V04 PROTEIN_ASSOCIATION: acyl-lipid desaturase (delta 12) SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.99.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380050V04 PROTEIN_ASSOCIATION: zeta-carotene desaturase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.99.30 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380050V04 PROTEIN_ASSOCIATION: zeta-carotene desaturase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.99.30 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030043V04 PROTEIN_ASSOCIATION: cytochrome P450, CYP120A1 SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.-.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030043V04 PROTEIN_ASSOCIATION: cytochrome P450, CYP120A1 SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.-.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010175V04 or SP60040015V04 PROTEIN_ASSOCIATION: beta-carotene hydroxylase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.13.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010175V04 or SP60040015V04 PROTEIN_ASSOCIATION: beta-carotene hydroxylase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.13.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030043V04 PROTEIN_ASSOCIATION: cytochrome P450, CYP120A1 SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.-.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030043V04 PROTEIN_ASSOCIATION: cytochrome P450, CYP120A1 SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.-.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010175V04 or SP60040015V04 PROTEIN_ASSOCIATION: beta-carotene hydroxylase SUBSYSTEM: S_Carotenoid biosynthesis PROTEIN_CLASS: 1.14.13.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20200021V04 PROTEIN_ASSOCIATION: chlorophyll a synthase SUBSYSTEM: S_Chlorophyll a biosynthesis I PROTEIN_CLASS: 2.5.1.62 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440091V04 or SP30110035V04 or SP60130069V04 or SP80060104V04 PROTEIN_ASSOCIATION: Magnesium protoporphyrin IX chelatase subunit I SUBSYSTEM: S_Chlorophyllide a biosynthesis PROTEIN_CLASS: 6.6.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250104V04 PROTEIN_ASSOCIATION: S-adenosylmethionine-Mg-protoporphyrin IX methyltransferase SUBSYSTEM: S_Chlorophyllide a biosynthesis PROTEIN_CLASS: 2.1.1.11 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390010V04 PROTEIN_ASSOCIATION: Mg-protoporphyrin IX monomethyl ester oxidative cyclase SUBSYSTEM: S_Chlorophyllide a biosynthesis PROTEIN_CLASS: 1.14.13.81 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390010V04 PROTEIN_ASSOCIATION: Mg-protoporphyrin IX monomethyl ester oxidative cyclase SUBSYSTEM: S_Chlorophyllide a biosynthesis PROTEIN_CLASS: 1.14.13.81 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390010V04 PROTEIN_ASSOCIATION: Mg-protoporphyrin IX monomethyl ester oxidative cyclase SUBSYSTEM: S_Chlorophyllide a biosynthesis PROTEIN_CLASS: 1.14.13.81 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10330020V04 or SP30030028V04 PROTEIN_ASSOCIATION: light-independent protochlorophyllide reductase subunit N SUBSYSTEM: S_Chlorophyllide a biosynthesis PROTEIN_CLASS: 1.18.-.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20180095V04 PROTEIN_ASSOCIATION: light-dependent NADPH-protochlorophyllide oxidoreductase SUBSYSTEM: S_Chlorophyllide a biosynthesis PROTEIN_CLASS: 1.3.1.33 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110039V04 or SP10440110V04 PROTEIN_ASSOCIATION: creatininase SUBSYSTEM: S_creatinine degradation I PROTEIN_CLASS: 3.5.2.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80100002V04 PROTEIN_ASSOCIATION: Sulfotransferase SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 2.8.2.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10240015V04 PROTEIN_ASSOCIATION: aldose 1-epimerase SUBSYSTEM: S_Entner-Doudoroff pathway PROTEIN_CLASS: 5.1.3.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140051V04 PROTEIN_ASSOCIATION: 5-formyltetrahydrofolate cyclo-ligase SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 6.3.3.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70140083V04 PROTEIN_ASSOCIATION: 5-oxoprolinase SUBSYSTEM: S_Glutathione metabolism PROTEIN_CLASS: 3.5.2.9 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150025V04 PROTEIN_ASSOCIATION: gamma-glutamyltranspeptidase precursor SUBSYSTEM: S_Glutathione metabolism PROTEIN_CLASS: 2.3.2.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040019V04 or SP70140075V04 PROTEIN_ASSOCIATION: glutathione transferase SUBSYSTEM: S_glutathione-mediated detoxification PROTEIN_CLASS: 2.5.1.18 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80070020V04-SP80070022V04 PROTEIN_ASSOCIATION: glycine dehydrogenase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 1.4.4.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70180032V04 PROTEIN_ASSOCIATION: glycine cleavage system T SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 2.1.2.10 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20240019V04 PROTEIN_ASSOCIATION: dihydrolipoamide dehydrogenase SUBSYSTEM: S_Glycine and Serine Metabolism PROTEIN_CLASS: 1.8.1.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70060043V04 PROTEIN_ASSOCIATION: monoglucosyldiacylglycerol (MGlcDG) synthase SUBSYSTEM: S_Membrane Lipid Metabolism (Glycolipid biosynthesis) PROTEIN_CLASS: 2.4.1.157 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: UNKNOWN PROTEIN_ASSOCIATION: monogalactosyldiacylglycerol (UDP-Glc epimerase) SUBSYSTEM: S_Membrane Lipid Metabolism (Glycolipid biosynthesis) PROTEIN_CLASS: 2.4.1.46 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30100013V04 PROTEIN_ASSOCIATION: MGDG galactosyltransferase SUBSYSTEM: S_Membrane Lipid Metabolism (Glycolipid biosynthesis) PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10260019V04 or SP10260021V04 or SP10260023V04 or SP10260024V04 or SP10260020V04 PROTEIN_ASSOCIATION: hydrogen dehydrogenase SUBSYSTEM: S_Hydrogen oxidation II (aerobic) PROTEIN_CLASS: 1.12.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060067V04 PROTEIN_ASSOCIATION: S-adenosylhomocysteine hydrolase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 3.3.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010027V04 or SP70060007V04 PROTEIN_ASSOCIATION: aldo-keto reductase SUBSYSTEM: S_Methylglyoxal Metabolism PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010027V04 or SP70060007V04 PROTEIN_ASSOCIATION: aldo-keto reductase SUBSYSTEM: S_Methylglyoxal Metabolism PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30150026V04 PROTEIN_ASSOCIATION: ferredoxin-nitrate reductase SUBSYSTEM: S_Nitrogen Metabolism PROTEIN_CLASS: 1.7.7.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040051V04 or SP30190013V04 PROTEIN_ASSOCIATION: ferredoxin-nitrite reductase SUBSYSTEM: S_Nitrogen Metabolism PROTEIN_CLASS: 1.7.7.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30140099V04 PROTEIN_ASSOCIATION: 4a-hydroxytetrahydrobiopterin dehydratase SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 4.2.1.96 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70180136V04 PROTEIN_ASSOCIATION: heme oxygenase SUBSYSTEM: S_Phycocyanobilin biosynthesis PROTEIN_CLASS: 1.14.99.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70090252V04 PROTEIN_ASSOCIATION: 3Z-phycocyanobilin:ferredoxin oxidoreductase SUBSYSTEM: S_Phycocyanobilin biosynthesis PROTEIN_CLASS: 1.3.7.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20090005V04 or SP20170059V04 or SP20260019V04 or SP50110020V04 or SP60010083V04 or SP70080078V04 PROTEIN_ASSOCIATION: 4-hydroxybenzoate-octaprenyl transferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.5.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10010013V04 or SP10110048V04 PROTEIN_ASSOCIATION: prepilin peptidase / N-methyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.1.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060022V04 PROTEIN_ASSOCIATION: geranylgeranyl reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.3.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060022V04 PROTEIN_ASSOCIATION: geranylgeranyl reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.3.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060022V04 PROTEIN_ASSOCIATION: geranylgeranyl reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.3.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010050V04 PROTEIN_ASSOCIATION: 4-hydroxyphenylpyruvate dioxygenase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.13.11.27 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: homogentisate solanyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80020012V04 or SP10010013V04 or SP10110048V04 PROTEIN_ASSOCIATION: 2-methyl-6-phytylbenzoquinone methyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 2.1.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20170051V04 or SP30090011V04 PROTEIN_ASSOCIATION: Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis --B6 PROTEIN_CLASS: 1.2.1.72 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: phosphoserine aminotransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis --B6 PROTEIN_CLASS: 2.6.1.52 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110047V04 PROTEIN_ASSOCIATION: 4-phosphoerythronate dehydrogenase/D-3-phosphoglycerate dehydrogenase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis --B6 PROTEIN_CLASS: 1.1.1.290 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250194V04 PROTEIN_ASSOCIATION: 4-hydroxythreonine-4-phosphate dehydrogenase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis --B6 PROTEIN_CLASS: 1.1.1.262 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: spontaneous PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis --B6 PROTEIN_CLASS: spontaneous4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP40080017V04 PROTEIN_ASSOCIATION: pyridoxine 5'-phosphate synthase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis --B6 PROTEIN_CLASS: 2.6.99.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70010009V04 PROTEIN_ASSOCIATION: spermine synthase SUBSYSTEM: S_Arginine and Proline Metabolism PROTEIN_CLASS: 2.5.1.22 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050142V04 PROTEIN_ASSOCIATION: sulfolipid biosynthesis protein SUBSYSTEM: S_Sulfolipid biosynthesis PROTEIN_CLASS: 3.1.3.1.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20110140V04 PROTEIN_ASSOCIATION: sulfolipid sulfoquinovosyldiacylglycerol biosynthesis protein SUBSYSTEM: S_Sulfolipid biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10350089V04 PROTEIN_ASSOCIATION: maltose alpha-D-glucosyltransferase SUBSYSTEM: S_Alternate Carbon Metabolism PROTEIN_CLASS: 5.4.99.16 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390090V04 or SP30060050V04 or SP30150039V04 PROTEIN_ASSOCIATION: UDP-N-acetylglucosamine 4-epimerase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 5.1.3.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20040104V04 and SP20040105V04 and SP20040106V04 PROTEIN_ASSOCIATION: urease SUBSYSTEM: S_Nitrogen Metabolism PROTEIN_CLASS: 3.5.1.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20090005V04 or SP20170059V04 or SP20260019V04 or SP50110020V04 or SP60010083V04 or SP70080078V04 PROTEIN_ASSOCIATION: 4-hydroxybenzoate-octaprenyl transferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--Vitamin E PROTEIN_CLASS: 2.5.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10010013V04 or SP10110048V04 PROTEIN_ASSOCIATION: prepilin peptidase / N-methyltransferase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--Vitamin E PROTEIN_CLASS: 2.1.1.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060030V04 PROTEIN_ASSOCIATION: tocopherol cyclase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--Vitamin E PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20140023V04 PROTEIN_ASSOCIATION: gamma-tocopherol methyltransferase, homolog of erg6/sed6 SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--Vitamin E PROTEIN_CLASS: 2.1.1.95 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30060030V04 PROTEIN_ASSOCIATION: tocopherol cyclase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--Vitamin E PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20140023V04 PROTEIN_ASSOCIATION: gamma-tocopherol methyltransferase, homolog of erg6/sed6 SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--Vitamin E PROTEIN_CLASS: 2.1.1.95 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70180009V04 PROTEIN_ASSOCIATION: photosystem II reaction center D1 protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbA3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30010001V04 PROTEIN_ASSOCIATION: photosystem II reaction center D1 protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbA $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150024V04 PROTEIN_ASSOCIATION: photosystem II reaction center D1 protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbA2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010099V04 PROTEIN_ASSOCIATION: photosystem II core light harvesting protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbB $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200028V04 PROTEIN_ASSOCIATION: photosystem II 44 kD reaction centre protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbC $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30200029V04 PROTEIN_ASSOCIATION: photosystem II reaction center D2 protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbD1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: AP05850008 PROTEIN_ASSOCIATION: photosystem II reaction center D2 protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbD2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: AP06110014 PROTEIN_ASSOCIATION: cytochrome b559 alpha chain SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbE $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: AP06110015 PROTEIN_ASSOCIATION: cytochrome b559 beta chain SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbF $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440115V04 PROTEIN_ASSOCIATION: photosystem II PsbH protein, PSII-H SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbH $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010099V04 PROTEIN_ASSOCIATION: photosystem II reaction center PsbI protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbI $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: AP06110016 PROTEIN_ASSOCIATION: photosystem II PsbJ protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbJ $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010017V04 PROTEIN_ASSOCIATION: photosystem II PsbK protein, PSII-K SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbK $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PY01790011V03 PROTEIN_ASSOCIATION: photosystem II PsbL protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbL $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70080075V04 PROTEIN_ASSOCIATION: photosystem II PsbM protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbM $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440114V04 PROTEIN_ASSOCIATION: PsbN protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbN $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250141V04 PROTEIN_ASSOCIATION: photosystem II manganese-stabilizing polypeptide SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbO $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70080075V04 PROTEIN_ASSOCIATION: photosystem II oxygen-evolving complex 23K protein PsbP homolog SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbP $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: photosystem II PsbTc protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbT-ycf8 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10380054V04 PROTEIN_ASSOCIATION: photosystem II 12 kDa extrinsic protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbU $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190022V04 PROTEIN_ASSOCIATION: cytochrome c550 SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbV $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030034V04 PROTEIN_ASSOCIATION: Photosystem II protein PsbW, class I SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbW $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70030034V04 PROTEIN_ASSOCIATION: photosystem II Psb28-2 protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psb28 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50110039V04 PROTEIN_ASSOCIATION: photosystem II PsbX protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbX $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20260016V04 PROTEIN_ASSOCIATION: photosystem II protein Y SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbY $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30070012V04 PROTEIN_ASSOCIATION: photosystem II PsbZ protein SUBSYSTEM: S_Photosynthesis system II PROTEIN_CLASS: psbZ $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70060016V04 and SP70060013V04 PROTEIN_ASSOCIATION: photosystem I reaction center subunit Ia SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: psaA $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010111V04 or SP20040121V04 or SP20160010V04 or SP20180116V04 or SP10150054V04 or SP20180118V04 or SP40050023V04 or SP10150046V04 or SP10150053V04 or SP80100020V04 or SP10430033V04 PROTEIN_ASSOCIATION: photosystem I reaction center subunit VII SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: psaC $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: (SP20110069V04 and SP10430032V04 and SP20110070V04) and SP10380075V04 and (SP30120080V04 or SP30120081V04 or SP30120079V04 or SP30120079V04 or SP30120077V04 or SP30120075V04 or SP30120074V04 or SP10440148V04 or SP70090246V04 or SP70090247V04 or SP70090248V04 or SP10090021V04 or SP60130011V04 or SP40050011V04) PROTEIN_ASSOCIATION: cytochrome b6 SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: petB $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP70020119V04 PROTEIN_ASSOCIATION: ferredoxin-NADP+ oxidoreductase SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: 1.18.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: AP06860007 PROTEIN_ASSOCIATION: ferredoxin-NADP+ oxidoreductase SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: 1.18.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: AP07740004 PROTEIN_ASSOCIATION: ferredoxin-NADP+ oxidoreductase SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: 1.18.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10230007V04 PROTEIN_ASSOCIATION: ferredoxin-NADP+ oxidoreductase SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: 1.18.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10230007V04 PROTEIN_ASSOCIATION: ferredoxin-NADP+ oxidoreductase SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: 1.18.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10230007V04 PROTEIN_ASSOCIATION: ferredoxin-NADP+ oxidoreductase SUBSYSTEM: S_Photosynthesis system I PROTEIN_CLASS: 1.18.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10030073V04 PROTEIN_ASSOCIATION: ferredoxin SUBSYSTEM: S_Unassigned PROTEIN_CLASS: 1.18.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: UDP-glucuronate decarboxylase SUBSYSTEM: S_UDP-D-xylose biosynthesis PROTEIN_CLASS: 4.1.1.35 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP50150099V04 PROTEIN_ASSOCIATION: UDP-glucuronic acid epimerase SUBSYSTEM: S_UDP-D-galacturonate biosynthesis PROTEIN_CLASS: 5.1.3.6 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10430004V04 PROTEIN_ASSOCIATION: adenosine-3'(2'),5'-bisphosphate nucleotidase SUBSYSTEM: S_Cysteine Metabolism PROTEIN_CLASS: 3.1.3.7 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080096V04 PROTEIN_ASSOCIATION: biotin-carboxyl carrier protein SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--biotin PROTEIN_CLASS: 6.3.4.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: FSC_exSpi PROTEIN_ASSOCIATION: N-acetylneuraminate synthase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.5.1.56 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10390094V04 PROTEIN_ASSOCIATION: CMP-N-acetylneuraminic acid synthetase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 2.7.7.43 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010110V04 PROTEIN_ASSOCIATION: CoB-CoM heterodisulfide reductase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--coenzyme B/coenzyme M regeneration PROTEIN_CLASS: 1.8.98.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060227V04 PROTEIN_ASSOCIATION: 2-phosphosulfolactate phosphatase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis--coenzyme M biosynthesis PROTEIN_CLASS: 3.1.3.71 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20250073V04 PROTEIN_ASSOCIATION: undecaprenyl pyrophosphate phosphatase SUBSYSTEM: S_Cell Envelope Biosynthesis PROTEIN_CLASS: 3.6.1.27 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080008V04 or SP30200034V04 or SP70090272V04 or SP70090277V04 or SP60010108V04 PROTEIN_ASSOCIATION: 3-oxoacyl-(acyl carrier protein) synthase SUBSYSTEM: S_Membrane Lipid Metabolism PROTEIN_CLASS: 2.3.1.180 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440011V04 PROTEIN_ASSOCIATION: delta 9 acyl-lipid desaturase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.14.19.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050158V04 PROTEIN_ASSOCIATION: delta 12 acyl-lipid desaturase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.14.99.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10450064V04 PROTEIN_ASSOCIATION: delta 6 acyl-lipid desaturase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid biosynthesis) PROTEIN_CLASS: 1.14.19.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440011V04 PROTEIN_ASSOCIATION: delta 9 acyl-lipid desaturase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid desaturation) PROTEIN_CLASS: 1.14.19.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10440011V04 PROTEIN_ASSOCIATION: delta 9 acyl-lipid desaturase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid desaturation) PROTEIN_CLASS: 1.14.19.1 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80050158V04 PROTEIN_ASSOCIATION: delta 12 acyl-lipid desaturase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid desaturation) PROTEIN_CLASS: 1.14.99.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10450064V04 PROTEIN_ASSOCIATION: delta 6 acyl-lipid desaturase SUBSYSTEM: S_Membrane Lipid Metabolism (fatty acid desaturation) PROTEIN_CLASS: 1.14.19.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60030001V04 PROTEIN_ASSOCIATION: glycerol-3-phosphate acyltransferase SUBSYSTEM: S_Membrane Lipid Metabolism (phospholipid biosynthesis) PROTEIN_CLASS: 2.3.1.15 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10190090V04 or SP60030001V04 PROTEIN_ASSOCIATION: 1-acyl-sn-glycerol-3-phosphate acyltransferase SUBSYSTEM: S_Membrane Lipid Metabolism (phospholipid biosynthesis) PROTEIN_CLASS: 2.3.1.51 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10200036V04 or SP80060097V04 PROTEIN_ASSOCIATION: phosphatidate cytidylyltransferase SUBSYSTEM: S_Membrane Lipid Metabolism (phospholipid biosynthesis) PROTEIN_CLASS: 2.7.7.41 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80060264V04 PROTEIN_ASSOCIATION: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SUBSYSTEM: S_Membrane Lipid Metabolism (phospholipid biosynthesis) PROTEIN_CLASS: 2.7.8.5 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP20080009V04 PROTEIN_ASSOCIATION: phosphatidylglycerophosphate phosphatase SUBSYSTEM: S_Membrane Lipid Metabolism (phospholipid biosynthesis) PROTEIN_CLASS: 3.1.3.27 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10110024V04 or SP40090072V04 PROTEIN_ASSOCIATION: cardiolipin synthase SUBSYSTEM: S_Membrane Lipid Metabolism (phospholipid biosynthesis) PROTEIN_CLASS: 2.7.8.- $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP80020007V04 PROTEIN_ASSOCIATION: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase SUBSYSTEM: S_Methionine Metabolism PROTEIN_CLASS: 2.1.1.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP10040028V04 or SP10450088V04 or SP30200035V04 or SP80080010V04 PROTEIN_ASSOCIATION: SUBSYSTEM: S_Methionine Metabolism PROTEIN_CLASS: 2.1.1.37 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: phosphatidate phosphatase SUBSYSTEM: S_Membrane Lipid Metabolism (Glycolipid biosynthesis) PROTEIN_CLASS: 3.1.3.4 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP60010066V04 or SP60010067V04 or SP60010069V04 PROTEIN_ASSOCIATION: NAD(P) transhydrogenase SUBSYSTEM: S_Cofactor and Prosthetic Group Biosynthesis PROTEIN_CLASS: 1.6.1.2 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: NfC PROTEIN_ASSOCIATION: ATPase SUBSYSTEM: S_ATP maintenance PROTEIN_CLASS: 3.6.1.3 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: SP30050013V04 and SP30050014V04 and SP30050015V04 and SP30050016V04 and SP30050017V04 and SP30050019V04 and SP30200021V04 and SP70090316V04 PROTEIN_ASSOCIATION: ATP synthase SUBSYSTEM: S_ATP synthesis from choloplast --Chla PROTEIN_CLASS: 3.6.3.14 $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Lighting Reaction -- Chen Yang PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Oxidative Phosphorylation--Chen Yange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Oxidative Phosphorylation--Chen Yange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_EPS biosynthesis PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Macromolecules PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: non-gene associated reaction SUBSYSTEM: S_Biomass PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_ PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_ PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Exopolysaccharide transport PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Exopolysaccharide transport PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Light transport PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Light transport PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_O2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_O2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_O2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_O2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_CO2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_CO2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_HCO3- entry PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_HCO3- entry PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Proton transport PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Proton transport PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_H2O exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_H2O exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-glucose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-glucose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-glucose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-glucose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-Fructose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-Fructose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-Lactose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-Lactose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-Galactose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_D-Galactose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Maltose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Maltose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sucrose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sucrose exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Citrate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Citrate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Acetate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Acetate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Phosphate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Phosphate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sulfate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sulfate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Nitrate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Nitrate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Mg exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Mg exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Calcium exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Calcium exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Molybdenum exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Molybdenum exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sodium exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sodium exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_K+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_K+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Mn2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Mn2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ammonia exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ammonia exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cu2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cu2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Fe2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Fe2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_H2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_H2 exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Co2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Co2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cadmium exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cadmium exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Fe3+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Fe3+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Hydrogen peroxide transport via diffusion PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Hydrogen peroxide transport via diffusion PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_H2S transport via diffusion PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_H2S transport via diffusion PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Hg2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Hg2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ni2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ni2+ exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Nitrite exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Nitrite exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Superoxide anion exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Superoxide anion exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sulfite exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Sulfite exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Adenine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Adenine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cytosine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Cytosine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Uracil exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Uracil exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Thymidine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Thymidine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_alpha-ketoglutarate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_alpha-ketoglutarate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Succinate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Succinate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Malate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Malate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Fumarate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Fumarate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Pyruvate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Pyruvate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ethanol exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ethanol exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Lactate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Lactate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ribose transport via diffusion PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Ribose transport via diffusion PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Adenosylcobalamin(coenzymeB12) exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Adenosylcobalamin(coenzymeB12) PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Thiamin exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Thiamin exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Isoleucine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Isoleucine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Leucine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Leucine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Lysine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Lysine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Methionine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Methionine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Phenylalanine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Phenylalanine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Threonine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Threonine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Tryptophan exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Tryptophan exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Valine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Valine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Arginine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Arginine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Histidine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Histidine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Alanine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Alanine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Aspartate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Aspartate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Glutamate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Glutamate exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Cysteine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_L-Cysteine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Glycine exchange PROTEIN_CLASS: $\mathrm{FLUX\_VALUE}$ GENE_ASSOCIATION: PROTEIN_ASSOCIATION: SUBSYSTEM: S_Glycine exchange PROTEIN_CLASS: