Bozdech - Pilot co-coexpression analysis

21 cluster pairs

Cluster Pair #0: 5 gene pairs.

P.falciparumD.melanogasterBlast evalue
PFA0400c ?
beta3 proteasome subunit, putative

endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0026380 ?
proteasome complex (sensu Eukaryota) ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism (IEA) ?
8.96831e-44

BLAST
PF07_0112 ?
proteasome subunit alpha type 5, putative

endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) (IEA) ?
ubiquitin-dependent protein catabolism ?
proteasome core complex, alpha-subunit complex (sensu Eukaryota) ?
FBgn0016697 ?
proteasome complex (sensu Eukaryota) ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism ?
0

BLAST
PFC0745c ?
proteasome component C8, putative

endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0023175 ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
proteolysis and peptidolysis (IEA) ?
ubiquitin-dependent protein catabolism (IEA) ?
5e-32

BLAST
MAL8P1.128 ?
proteasome subunit alpha, putative

endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0026781 ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
proteolysis and peptidolysis (IEA) ?
ubiquitin-dependent protein catabolism (IEA) ?
6.00036e-42

BLAST
PF13_0282 ?
proteasome subunit, putative

endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0003150 ?
proteasome complex (sensu Eukaryota) ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism ?
0

BLAST

Cluster Pair #1: 4 gene pairs.

P.falciparumD.melanogasterBlast evalue
MAL8P1.142 ?
proteasome beta-subunit

endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism (IEA) ?
FBgn0037314 ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
nucleus ?
cytoplasm ?
proteasome core complex (sensu Eukaryota) ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism ?
2e-26

BLAST
PFC0520w ?
26S proteasome regulatory subunit S14, putative

proteasome regulatory particle (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0028693 ?
endopeptidase activity ?
proteasome regulatory particle (sensu Eukaryota) ?
proteolysis and peptidolysis ?
proteasome regulatory particle, lid subcomplex (sensu Eukaryota) ?
6e-27

BLAST
PFE0915c ?
proteasome subunit beta type 1

endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0002284 ?
proteasome complex (sensu Eukaryota) ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism ?
5e-40

BLAST
PFI1545c ?
proteasome precursor, putative

threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) (IEA) ?
ubiquitin-dependent protein catabolism (IEA) ?
FBgn0023174 ?
endopeptidase activity ?
threonine endopeptidase activity (IEA) ?
proteasome core complex (sensu Eukaryota) ?
proteolysis and peptidolysis (IEA) ?
ubiquitin-dependent protein catabolism (IEA) ?
1e-08

BLAST

Cluster Pair #2: 4 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF11_0461 ?
rab6

GTP binding ?
Golgi apparatus ?
intracellular protein transport ?
small GTPase mediated signal transduction (IEA) ?
protein transport (IEA) ?
FBgn0015797 ?
compound eye morphogenesis (sensu Endopterygota) ?
GTPase activity ?
GTP binding (IEA) ?
intracellular protein transport (IEA) ?
receptor mediated endocytosis (IEA) ?
signal transduction (IEA) ?
small GTPase mediated signal transduction (IEA) ?
regulation of exocytosis (IEA) ?
0

BLAST
PF10_0081 ?
26S proteasome regulatory subunit 4, putative

nucleotide binding (IEA) ?
endopeptidase activity ?
ATP binding (IEA) ?
nucleus (IEA) ?
cytoplasm (IEA) ?
proteasome regulatory particle (sensu Eukaryota) ?
proteolysis and peptidolysis ?
hydrolase activity (IEA) ?
ATPase activity (IEA) ?
nucleoside-triphosphatase activity (IEA) ?
protein catabolism (IEA) ?
FBgn0015282 ?
proteasome complex (sensu Eukaryota) ?
endopeptidase activity ?
ATP binding (IEA) ?
nucleus (IEA) ?
cytoplasm (IEA) ?
proteasome regulatory particle (sensu Eukaryota) ?
proteolysis and peptidolysis ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism ?
proteasome regulatory particle, base subcomplex (sensu Eukaryota) ?
ATPase activity ?
0

BLAST
PF08_0109 ?
hypothetical protein

FBgn0015283 ?
proteasome complex (sensu Eukaryota) ?
endopeptidase activity ?
proteasome regulatory particle (sensu Eukaryota) ?
proteolysis and peptidolysis ?
ubiquitin-dependent protein catabolism ?
chromosome segregation ?
proteasome regulatory particle, base subcomplex (sensu Eukaryota) ?
protein metabolism (IEA) ?
3e-30

BLAST
MAL13P1.343 ?
proteasome regulatory subunit, putative

proteasome regulatory particle (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0028694 ?
endopeptidase activity ?
proteasome regulatory particle (sensu Eukaryota) ?
proteolysis and peptidolysis ?
proteasome regulatory particle, lid subcomplex (sensu Eukaryota) ?
0

BLAST

Cluster Pair #3: 9 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF10_0327 ?
Myb2 protein

DNA binding ?
nucleus (IEA) ?
regulation of transcription, DNA-dependent ?
FBgn0035136 ?
regulation of progression through cell cycle (IEA) ?
nuclear mRNA splicing, via spliceosome ?
DNA binding (IEA) ?
spliceosome complex ?
regulation of transcription from RNA polymerase II promoter (IEA) ?
transcription regulator activity (IEA) ?
RNA splicing factor activity, transesterification mechanism ?
0

BLAST
PFE1530c ?
hypothetical protein, conserved

nucleus (IEA) ?
FBgn0039557 ?
nucleus (IEA) ?
5.00264e-43

BLAST
MAL7P1.81 ?
eukaryotic translation initiation factor 3 37.28 kDa subunit, putative

translation initiation factor activity ?
eukaryotic translation initiation factor 3 complex ?
regulation of translational initiation ?
FBgn0015834 ?
translation initiation factor activity ?
cytosol ?
eukaryotic translation initiation factor 3 complex ?
protein biosynthesis ?
translational initiation ?
0

BLAST
PF07_0066 ?
hypothetical protein

nucleic acid binding (IEA) ?
FBgn0005411 ?
nucleotide binding (IEA) ?
spliceosome assembly ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
nuclear mRNA splicing, via spliceosome ?
mRNA binding ?
nucleus ?
spliceosome complex ?
snRNP U2 ?
poly-pyrimidine tract binding ?
RNA splicing factor activity, transesterification mechanism ?
protein heterodimerization activity ?
nuclear export ?
2e-21

BLAST
PFL0815w ?
DNA-binding chaperone, putative

DNA binding (IEA) ?
nucleus (IEA) ?
protein folding (IEA) ?
heat shock protein binding (IEA) ?
unfolded protein binding (IEA) ?
FBgn0037051 ?
nucleic acid binding (IEA) ?
DNA binding (IEA) ?
nucleus (IEA) ?
protein folding ?
heat shock protein binding (IEA) ?
regulation of transcription (IEA) ?
unfolded protein binding ?
1e-19

BLAST
PF11_0200 ?
U2 snRNP auxiliary factor, small subunit, putative

nuclear mRNA splicing, via spliceosome ?
nucleic acid binding (IEA) ?
RNA binding ?
nucleus (IEA) ?
snRNP U2 ?
FBgn0017457 ?
nucleotide binding (IEA) ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
nuclear mRNA splicing, via spliceosome ?
mRNA binding ?
nucleus ?
spliceosome complex ?
snRNP U2 ?
poly-pyrimidine tract binding ?
zinc ion binding (IEA) ?
0

BLAST
PFL1715w ?
hypothetical protein

nucleus (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
methyltransferase activity (IEA) ?
FBgn0032016 ?
transcription factor activity ?
nucleus ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity ?
0

BLAST
MAL13P1.132 ?
microfibril-associated protein homologue, putative

extracellular matrix structural constituent ?
extracellular region (IEA) ?
extracellular matrix (sensu Metazoa) ?
FBgn0035294 ?
microfibril ?
structural molecule activity (IEA) ?
cytoskeleton organization and biogenesis (IEA) ?
3e-18

BLAST
MAL13P1.261 ?
hypothetical protein

FBgn0035249 ?
0.049

BLAST

Cluster Pair #4: 15 gene pairs.

P.falciparumD.melanogasterBlast evalue
PFL2395c ?
dimethyladenosine transferase, putative

rRNA modification ?
rRNA (adenine-N6,N6-)-dimethyltransferase activity ?
mitochondrion ?
rRNA methyltransferase activity (IEA) ?
S-adenosylmethionine-dependent methyltransferase activity (IEA) ?
membrane ?
apicoplast ?
FBgn0036197 ?
rRNA modification (IEA) ?
rRNA (adenine-N6,N6-)-dimethyltransferase activity (IEA) ?
nucleic acid binding (IEA) ?
mitochondrion ?
rRNA processing (IEA) ?
rRNA metabolism (IEA) ?
rRNA (adenine) methyltransferase activity ?
3e-13

BLAST
PFL2445c ?
hypothetical protein

FBgn0035411 ?
0.059

BLAST
PF14_0576 ?
ubiquitin carboxyl-terminal hydrolase, putative

ubiquitin thiolesterase activity ?
intracellular (IEA) ?
ubiquitin-dependent protein catabolism ?
FBgn0010288 ?
ubiquitin thiolesterase activity ?
intracellular (IEA) ?
proteolysis and peptidolysis (IEA) ?
ubiquitin-dependent protein catabolism (IEA) ?
protein deubiquitination ?
1e-15

BLAST
PF14_0378 ?
triose-phosphate isomerase

triose-phosphate isomerase activity ?
gluconeogenesis ?
glycolysis ?
pentose-phosphate shunt ?
fatty acid biosynthesis ?
metabolism (IEA) ?
FBgn0003738 ?
triose-phosphate isomerase activity ?
gluconeogenesis (IEA) ?
glycolysis (IEA) ?
pentose-phosphate shunt (IEA) ?
intramolecular transferase activity (IEA) ?
0

BLAST
PFI1105w ?
Phosphoglycerate kinase

phosphoglycerate kinase activity (IEA) ?
glycolysis (IEA) ?
FBgn0003075 ?
phosphoglycerate kinase activity ?
cytoplasm ?
glycolysis ?
phosphorylation (IEA) ?
carbohydrate kinase activity (IEA) ?
0

BLAST
PF14_0370 ?
RNA helicase, putative

nucleotide binding (IEA) ?
nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
nucleoside-triphosphatase activity (IEA) ?
FBgn0038344 ?
nuclear mRNA splicing, via spliceosome ?
nucleic acid binding (IEA) ?
RNA helicase activity ?
helicase activity ?
ATP binding (IEA) ?
snRNP U5 ?
ATP-dependent helicase activity (IEA) ?
small nuclear ribonucleoprotein complex ?
0

BLAST
PF14_0301 ?
hypothetical protein

mitochondrion ?
FBgn0012066 ?
nucleotide binding (IEA) ?
nucleic acid binding (IEA) ?
DNA binding (IEA) ?
delta DNA polymerase activity ?
phospholipase A2 activity (IEA) ?
transporter activity (IEA) ?
leading strand elongation ?
lagging strand elongation ?
DNA repair (IEA) ?
DNA recombination (IEA) ?
phospholipid metabolism (IEA) ?
transport (IEA) ?
3'-5'-exodeoxyribonuclease activity ?
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity ?
membrane (IEA) ?
lipid catabolism (IEA) ?
0.039

BLAST
MAL13P1.345 ?
hypothetical protein

FBgn0031848 ?
0.003

BLAST
PF14_0598 ?
glyceraldehyde-3-phosphate dehydrogenase

glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity ?
mitochondrion ?
glucose metabolism (IEA) ?
gluconeogenesis ?
glycolysis ?
glyceraldehyde-3-phosphate dehydrogenase activity (IEA) ?
NAD binding (IEA) ?
** also with: FBgn0001091, clust.pair #4
FBgn0001092 ?
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity ?
cytoplasm ?
glycolysis ?
NAD binding (IEA) ?
0

BLAST
PF14_0598 ?
glyceraldehyde-3-phosphate dehydrogenase

glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity ?
mitochondrion ?
glucose metabolism (IEA) ?
gluconeogenesis ?
glycolysis ?
glyceraldehyde-3-phosphate dehydrogenase activity (IEA) ?
NAD binding (IEA) ?
** also with: FBgn0001092, clust.pair #4
FBgn0001091 ?
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity ?
cytoplasm ?
glycolysis ?
NAD binding (IEA) ?
0

BLAST
PFL1545c ?
chaperonin cpn60

protein binding (IEA) ?
ATP binding (IEA) ?
protein folding ?
apicoplast ?
cellular protein metabolism (IEA) ?
unfolded protein binding ?
FBgn0015245 ?
ATP binding (IEA) ?
mitochondrion ?
mitochondrial matrix ?
protein folding ?
'de novo' protein folding ?
protein targeting to mitochondrion ?
response to stress ?
response to heat ?
protein refolding ?
ATPase activity, coupled (IEA) ?
unfolded protein binding ?
0

BLAST
PF13_0232 ?
Casein kinase II regulatory subunit, putative

protein kinase CK2 complex ?
protein amino acid phosphorylation ?
protein kinase CK2 regulator activity ?
FBgn0000259 ?
protein kinase activity ?
casein kinase activity ?
protein kinase CK2 activity ?
receptor signaling protein serine/threonine kinase activity (IEA) ?
nucleus ?
cytosol ?
protein kinase CK2 complex ?
protein amino acid phosphorylation ?
signal transduction (IEA) ?
rhythmic behavior ?
circadian rhythm ?
eclosion rhythm ?
protein kinase CK2 regulator activity ?
mushroom body development ?
7e-37

BLAST
PFA0500w ?
human hepatopoietin-like protein, putative

cell proliferation ?
FBgn0031068 ?
mitochondrion ?
electron transport (IEA) ?
oxidative phosphorylation (IEA) ?
flavin-linked sulfhydryl oxidase activity ?
3e-14

BLAST
PFC0975c ?
PFCYP19, cyclophilin, peptidyl-prolyl cis-trans isomerase

peptidyl-prolyl cis-trans isomerase activity ?
cytosol ?
protein folding ?
cyclosporin A binding ?
FBgn0004432 ?
peptidyl-prolyl cis-trans isomerase activity ?
cytoplasm ?
cytosol ?
protein folding ?
protein targeting (IEA) ?
defense response (IEA) ?
transcription elongation factor complex b ?
cyclin-dependent protein kinase regulator activity ?
nuclear cyclin-dependent protein kinase holoenzyme complex ?
salivary gland cell death ?
autophagic cell death ?
0

BLAST
PFL1710c ?
tetQ family GTPase, putative

translation elongation factor activity ?
GTP binding (IEA) ?
protein biosynthesis (IEA) ?
translational elongation ?
apicoplast ?
FBgn0031898 ?
translation elongation factor activity ?
GTP binding (IEA) ?
mitochondrion ?
translational elongation ?
3e-23

BLAST

Cluster Pair #5: 4 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF13_0334 ?
polynucleotide kinase, putative

damaged DNA binding ?
response to DNA damage stimulus ?
FBgn0037578 ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
DNA metabolism (IEA) ?
DNA repair (IEA) ?
kinase activity (IEA) ?
nucleotide kinase activity (IEA) ?
2e-17

BLAST
PF11_0078 ?
hypothetical protein

FBgn0030354 ?
mRNA catabolism, nonsense-mediated decay ?
nucleic acid binding (IEA) ?
RNA helicase activity (IEA) ?
helicase activity ?
cytoplasm ?
1e-14

BLAST
PFI0650c ?
hypothetical protein

FBgn0033373 ?
0.002

BLAST
PF13_0142 ?
u6 snRNA-associated sm-like protein, putative

nucleus (IEA) ?
spliceosome complex ?
small nucleolar ribonucleoprotein complex (IEA) ?
mRNA processing (IEA) ?
ribonucleoprotein complex (IEA) ?
RNA splicing factor activity, transesterification mechanism ?
FBgn0034564 ?
nuclear mRNA splicing, via spliceosome ?
spliceosome complex ?
snRNP U6 ?
small nuclear ribonucleoprotein complex ?
2e-20

BLAST

Cluster Pair #6: 2 gene pairs.

P.falciparumD.melanogasterBlast evalue
PFI1680w ?
hypothetical protein

FBgn0034068 ?
apoptosis (IEA) ?
induction of apoptosis (IEA) ?
signal transduction (IEA) ?
intracellular signaling cascade (IEA) ?
4e-07

BLAST
PF14_0632 ?
26S proteasome subunit, putative

regulation of progression through cell cycle (IEA) ?
endopeptidase activity ?
proteasome regulatory particle (sensu Eukaryota) ?
ubiquitin-dependent protein catabolism ?
FBgn0028692 ?
regulation of progression through cell cycle (IEA) ?
endopeptidase activity ?
binding (IEA) ?
proteasome regulatory particle (sensu Eukaryota) ?
proteolysis and peptidolysis ?
proteasome regulatory particle, base subcomplex (sensu Eukaryota) ?
enzyme regulator activity (IEA) ?
0

BLAST

Cluster Pair #7: 31 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF13_0014 ?
40S ribosomal protein S7 homologue, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0039757 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
5e-31

BLAST
PF13_0224 ?
60S ribosomal subunit protein L18, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0010409 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
2e-32

BLAST
PF14_0027 ?
ribosomal S27a, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis (IEA) ?
protein modification (IEA) ?
FBgn0003942 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
protein binding ?
nucleus ?
cytoplasm ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
establishment and/or maintenance of chromatin architecture ?
regulation of transcription, DNA-dependent ?
protein biosynthesis ?
protein modification ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism ?
ubiquitin cycle ?
response to stress ?
2e-14

BLAST
PF10_0038 ?
ribosomal protein S20e, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
FBgn0019936 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
2e-35

BLAST
PF13_0132 ?
60S ribosomal protein L23a, putative

structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
rRNA binding ?
FBgn0026372 ?
nucleotide binding (IEA) ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
2e-24

BLAST
PFE0810c ?
40S ribosomal subunit protein S14, putative

RNA binding ?
structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
** also with: FBgn0004404, clust.pair #7
FBgn0004403 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PFE0810c ?
40S ribosomal subunit protein S14, putative

RNA binding ?
structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
** also with: FBgn0004403, clust.pair #7
FBgn0004404 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PFI0190w ?
ribosomal protein L32, putative

structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis (IEA) ?
FBgn0002626 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
4e-28

BLAST
PF13_0213 ?
60S ribosomal subunit protein L6e, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0039857 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis (IEA) ?
1e-15

BLAST
PFB0830w ?
Ribosomal protein S26e, putative

structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrion ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0004413 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
1e-31

BLAST
PF07_0080 ?
40S ribosomal protein S10, putative

structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0031035 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
actin binding (IEA) ?
structural constituent of cytoskeleton (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis (IEA) ?
cytoskeleton organization and biogenesis (IEA) ?
microtubule binding (IEA) ?
intermediate filament binding (IEA) ?
2e-25

BLAST
PFC0295c ?
40S ribosomal protein S12, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0014027 ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
2e-22

BLAST
PFC0300c ?
60S ribosomal protein L7, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
large ribosomal subunit (IEA) ?
transcription regulator activity (IEA) ?
FBgn0005593 ?
mRNA binding ?
structural constituent of ribosome ?
cysteine-type endopeptidase activity (IEA) ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
proteolysis and peptidolysis (IEA) ?
rRNA binding ?
transcription regulator activity (IEA) ?
4e-39

BLAST
PF13_0045 ?
40S ribosomal protein S27, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0039300 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis (IEA) ?
7e-31

BLAST
PF13_0171 ?
60S ribosomal protein L23, putative

structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis (IEA) ?
FBgn0010078 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF14_0231 ?
ribosomal protein L7a, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
ribonucleoprotein complex (IEA) ?
ribosome biogenesis and assembly (IEA) ?
FBgn0014026 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
ribosome biogenesis and assembly (IEA) ?
0

BLAST
PF11_0272 ?
ribosomal protein S18, putative

RNA binding (IEA) ?
structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
small ribosomal subunit ?
FBgn0010411 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
translational initiation ?
0

BLAST
PF14_0579 ?
ribosomal protein L27, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0039359 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
5e-18

BLAST
PF08_0076 ?
40S ribosomal protein S16, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0034743 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
8.40779e-45

BLAST
PF14_0240 ?
ribosomal protein L21e, putative

structural constituent of ribosome ?
mitochondrion ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0032987 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
8e-33

BLAST
PF14_0655 ?
RNA helicase-1, putative

RNA cap binding ?
nucleic acid binding (IEA) ?
mRNA binding ?
translation initiation factor activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
regulation of translational initiation ?
ATP-dependent helicase activity ?
eukaryotic translation initiation factor 4F complex ?
** also with: FBgn0037573, clust.pair #7
FBgn0001942 ?
RNA cap binding ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
larval development (sensu Insecta) ?
RNA helicase activity ?
mRNA binding ?
translation initiation factor activity ?
ATP binding (IEA) ?
nucleus ?
cytosol ?
DNA unwinding ?
translational initiation ?
imaginal disc growth ?
dorsal/ventral axis specification ?
eukaryotic translation initiation factor 4F complex ?
single-stranded DNA-dependent ATP-dependent DNA helicase activity ?
0

BLAST
PF14_0655 ?
RNA helicase-1, putative

RNA cap binding ?
nucleic acid binding (IEA) ?
mRNA binding ?
translation initiation factor activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
regulation of translational initiation ?
ATP-dependent helicase activity ?
eukaryotic translation initiation factor 4F complex ?
** also with: FBgn0001942, clust.pair #7
FBgn0037573 ?
translation initiation factor activity ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
translational initiation ?
eukaryotic translation initiation factor 4F complex ?
0

BLAST
PFL2055w ?
40S ribosomal protein S17, putative

structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrion ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0005533 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
4e-30

BLAST
PFC0441c ?
hypothetical protein

FBgn0034654 ?
translation initiation factor activity ?
nucleus (IEA) ?
eukaryotic translation initiation factor 3 complex ?
translational initiation ?
2e-10

BLAST
PF11_0438 ?
Ribosomal protein, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
large ribosomal subunit ?
FBgn0037328 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
1e-22

BLAST
MAL13P1.92 ?
40S ribosomal protein S15, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
FBgn0034138 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
9.94922e-44

BLAST
PF13_0228 ?
40S ribosomal subunit protein S6, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0004922 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
immune response ?
0

BLAST
PFC0535w ?
60S ribosomal protein L26, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
large ribosomal subunit (IEA) ?
FBgn0036825 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
5e-30

BLAST
PF13_0268 ?
ribosomal protein L17, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
large ribosomal subunit (IEA) ?
FBgn0029897 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PFC0735w ?
40S ribosomal protein S15A, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0033555 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis (IEA) ?
0

BLAST
PFC0775w ?
40S ribosomal protein S11, putative

nucleic acid binding (IEA) ?
structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0033699 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
1.4013e-45

BLAST

Cluster Pair #8: 11 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF14_0661 ?
hypothetical protein, conserved

nucleic acid binding (IEA) ?
FBgn0020305 ?
mRNA binding (IEA) ?
nucleoplasm ?
nucleolus ?
rRNA processing ?
0.0005

BLAST
PF13_0177 ?
ATP-dependent RNA helicase, putative

nucleic acid binding (IEA) ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
FBgn0032919 ?
nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
metal ion transport (IEA) ?
metal ion binding (IEA) ?
0

BLAST
PFB0370c ?
RNA-binding protein, putative

FBgn0020305 ?
mRNA binding (IEA) ?
nucleoplasm ?
nucleolus ?
rRNA processing ?
0

BLAST
PF07_0092 ?
hypothetical protein, conserved

FBgn0030000 ?
0

BLAST
PFB0860c ?
RNA helicase, putative

nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
FBgn0032919 ?
nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
metal ion transport (IEA) ?
metal ion binding (IEA) ?
0

BLAST
PF14_0124 ?
actin II

microfilament motor activity ?
structural constituent of cytoskeleton ?
protein binding (IEA) ?
actin filament ?
cytoskeleton organization and biogenesis ?
** also with: FBgn0000043, clust.pair #9
FBgn0000042 ?
cytokinesis ?
structural constituent of cytoskeleton ?
protein binding (IEA) ?
ATP binding (IEA) ?
actin filament ?
cytoskeleton organization and biogenesis ?
sperm individualization ?
0

BLAST
PF14_0113 ?
hypothetical protein

RNA binding (IEA) ?
FBgn0032678 ?
0.007

BLAST
PF13_0341 ?
DNA-directed RNA polymerase 2, putative

DNA binding ?
DNA-directed RNA polymerase activity ?
DNA-directed RNA polymerase II, core complex ?
transcription (IEA) ?
transcription from RNA polymerase II promoter ?
FBgn0033571 ?
nucleic acid binding (IEA) ?
DNA binding (IEA) ?
DNA-directed RNA polymerase activity ?
DNA-directed RNA polymerase II, core complex ?
transcription from RNA polymerase II promoter ?
mRNA transcription (IEA) ?
0

BLAST
PFI1215w ?
splicesome-associated protein, putative

nucleic acid binding (IEA) ?
nucleus (IEA) ?
FBgn0014366 ?
nuclear mRNA splicing, via spliceosome ?
nucleic acid binding (IEA) ?
spliceosome complex ?
snRNP U2 ?
zinc ion binding (IEA) ?
fertilization ?
1.96182e-44

BLAST
PFE1115c ?
s-adenosylmethionine-dependent methyltransferase, putative

S-adenosylmethionine-dependent methyltransferase activity ?
FBgn0037543 ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
S-adenosylmethionine-dependent methyltransferase activity ?
0

BLAST
PF11_0191 ?
hypothetical protein

FBgn0038964 ?
mRNA binding (IEA) ?
nucleolus ?
rRNA metabolism (IEA) ?
small nuclear ribonucleoprotein complex ?
0

BLAST

Cluster Pair #9: 12 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF11_0250 ?
high mobility group-like protein NHP2, putative

structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
nucleus ?
ribosome (IEA) ?
protein biosynthesis (IEA) ?
ribonucleoprotein complex (IEA) ?
ribosome biogenesis and assembly (IEA) ?
FBgn0014026 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
ribosome biogenesis and assembly (IEA) ?
1e-05

BLAST
PFI0860c ?
ATP-dependant RNA helicase, putative

nucleic acid binding (IEA) ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
FBgn0033160 ?
nuclear mRNA splicing, via spliceosome ?
RNA helicase activity ?
structural constituent of ribosome (IEA) ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
spliceosome complex ?
ribosome (IEA) ?
protein biosynthesis (IEA) ?
ATP-dependent helicase activity ?
RNA splicing factor activity, transesterification mechanism ?
0

BLAST
PF14_0584 ?
ribosomal protein S4, putative

RNA binding (IEA) ?
structural constituent of ribosome ?
mitochondrial small ribosomal subunit ?
protein biosynthesis ?
FBgn0034232 ?
structural constituent of ribosome ?
mitochondrial ribosome ?
protein biosynthesis ?
3e-31

BLAST
PF14_0274 ?
hypothetical protein, conserved

FBgn0038272 ?
defense response (IEA) ?
peptidyl-diphthamide biosynthesis from peptidyl-histidine ?
2e-14

BLAST
PF07_0027 ?
DNA-directed RNA polymerase 2 8.2 kDa polypeptide, putative

DNA-directed RNA polymerase activity ?
DNA-directed RNA polymerase II, core complex ?
transcription (IEA) ?
transcription from RNA polymerase II promoter ?
FBgn0039218 ?
nucleic acid binding (IEA) ?
DNA binding (IEA) ?
DNA-directed RNA polymerase activity ?
nucleus ?
DNA-directed RNA polymerase II, core complex ?
transcription ?
transcription from RNA polymerase II promoter ?
regulation of transcription (IEA) ?
1e-16

BLAST
PF14_0124 ?
actin II

microfilament motor activity ?
structural constituent of cytoskeleton ?
protein binding (IEA) ?
actin filament ?
cytoskeleton organization and biogenesis ?
** also with: FBgn0000042, clust.pair #8
FBgn0000043 ?
cytokinesis ?
structural constituent of cytoskeleton ?
protein binding (IEA) ?
ATP binding (IEA) ?
actin filament ?
cytoskeleton organization and biogenesis ?
0

BLAST
PF10_0068 ?
hypothetical protein

nucleic acid binding (IEA) ?
FBgn0037701 ?
nucleotide binding (IEA) ?
mRNA binding ?
3e-11

BLAST
PF14_0068 ?
fibrillarin, putative

RNA binding (IEA) ?
nucleus (IEA) ?
small nucleolar ribonucleoprotein complex ?
mitochondrion ?
rRNA processing ?
FBgn0003062 ?
dense fibrillar component ?
mRNA binding ?
small nucleolar ribonucleoprotein complex ?
35S primary transcript processing ?
RNA processing ?
rRNA metabolism (IEA) ?
small nuclear ribonucleoprotein complex ?
0

BLAST
PF14_0635 ?
hypothetical protein, conserved

RNA binding (IEA) ?
FBgn0039233 ?
4e-32

BLAST
PFL2310w ?
hypothetical protein, conserved

nucleic acid binding (IEA) ?
FBgn0037220 ?
nucleotide binding (IEA) ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
mRNA binding ?
nucleus ?
zinc ion binding (IEA) ?
0

BLAST
PF14_0221 ?
hypothetical protein, conserved

GTP binding (IEA) ?
FBgn0034243 ?
receptor binding (IEA) ?
GTP binding ?
nucleus ?
intracellular protein transport (IEA) ?
cell surface receptor linked signal transduction (IEA) ?
intracellular signaling cascade (IEA) ?
0

BLAST
PF14_0174 ?
hypothetical protein, conserved

RNA binding (IEA) ?
pseudouridylate synthase activity (IEA) ?
RNA processing (IEA) ?
FBgn0023184 ?
pseudouridine synthesis ?
pseudouridylate synthase activity ?
nucleus ?
nucleolus ?
rRNA processing ?
chromosome segregation (IEA) ?
mitosis (IEA) ?
germ cell development ?
rRNA metabolism (IEA) ?
centromeric DNA binding (IEA) ?
0

BLAST

Cluster Pair #10: 12 gene pairs.

P.falciparumD.melanogasterBlast evalue
PFL2295w ?
hypothetical protein

rRNA processing (IEA) ?
ribonucleoprotein complex (IEA) ?
FBgn0030063 ?
small nucleolar ribonucleoprotein complex ?
rRNA processing ?
protein biosynthesis ?
7e-05

BLAST
PF07_0122 ?
hypothetical protein, conserved

FBgn0035524 ?
nucleolus ?
ribosomal large subunit biogenesis ?
7.00005e-41

BLAST
PF14_0150 ?
RNA polymerase small subunit, putative

DNA binding (IEA) ?
DNA-directed RNA polymerase activity ?
transcription ?
protein dimerization activity (IEA) ?
FBgn0032762 ?
nucleic acid binding (IEA) ?
DNA binding (IEA) ?
DNA-directed RNA polymerase activity ?
DNA-directed RNA polymerase I complex ?
transcription from RNA polymerase I promoter ?
transcription from RNA polymerase II promoter (IEA) ?
mRNA transcription (IEA) ?
protein dimerization activity (IEA) ?
4e-16

BLAST
PFI1085w ?
ubiquitin-like protein, putative

protein modification (IEA) ?
FBgn0003942 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
protein binding ?
nucleus ?
cytoplasm ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
establishment and/or maintenance of chromatin architecture ?
regulation of transcription, DNA-dependent ?
protein biosynthesis ?
protein modification ?
ATP-dependent proteolysis ?
ubiquitin-dependent protein catabolism ?
ubiquitin cycle ?
response to stress ?
0.002

BLAST
PF10_0277 ?
hypothetical protein, conserved

FBgn0039828 ?
nucleolus ?
processing of 27S pre-rRNA ?
8e-06

BLAST
PF10_0278 ?
hypothetical protein, conserved

FBgn0038585 ?
1e-09

BLAST
MAL13P1.341 ?
hypothetical protein, conserved

FBgn0033485 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome (IEA) ?
protein biosynthesis (IEA) ?
protein metabolism (IEA) ?
ribosome biogenesis and assembly (IEA) ?
8e-17

BLAST
PFB0865w ?
small nuclear ribonucleoprotein, putative

nucleus (IEA) ?
spliceosome complex ?
small nucleolar ribonucleoprotein complex (IEA) ?
mRNA processing (IEA) ?
RNA splicing ?
ribonucleoprotein complex (IEA) ?
RNA splicing factor activity, transesterification mechanism ?
FBgn0037434 ?
nuclear mRNA splicing, via spliceosome ?
spliceosome complex ?
small nuclear ribonucleoprotein complex ?
RNA splicing factor activity, transesterification mechanism ?
9e-25

BLAST
PF13_0310 ?
hypothetical protein

FBgn0029755 ?
0.0003

BLAST
PFI1070c ?
hypothetical protein

FBgn0032408 ?
nucleic acid binding (IEA) ?
mRNA binding (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
rRNA metabolism (IEA) ?
6e-31

BLAST
PFE1435c ?
hypothetical protein

FBgn0038473 ?
receptor binding (IEA) ?
hormone activity (IEA) ?
GTP binding (IEA) ?
intracellular (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
transport (IEA) ?
intracellular protein transport (IEA) ?
signal transduction (IEA) ?
cell surface receptor linked signal transduction (IEA) ?
intracellular signaling cascade (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid transport (IEA) ?
protein metabolism (IEA) ?
0.0002

BLAST
PF14_0194 ?
spliceosome-associated protein, putative

nucleic acid binding (IEA) ?
spliceosome complex ?
RNA splicing ?
RNA splicing factor activity, transesterification mechanism ?
FBgn0015818 ?
nucleotide binding (IEA) ?
nuclear mRNA splicing, via spliceosome ?
mRNA binding ?
spliceosome complex ?
snRNP U2 ?
histone mRNA 3'-end processing (IEA) ?
RNA splicing factor activity, transesterification mechanism ?
0

BLAST

Cluster Pair #11: 2 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF13_0318 ?
hypothetical protein, conserved

nucleic acid binding (IEA) ?
FBgn0037342 ?
nucleotide binding (IEA) ?
mRNA binding ?
1e-31

BLAST
PF11_0380 ?
hypothetical protein, conserved

protein folding (IEA) ?
membrane ?
heat shock protein binding (IEA) ?
unfolded protein binding (IEA) ?
FBgn0038195 ?
protein folding (IEA) ?
response to stress (IEA) ?
defense response (IEA) ?
protein metabolism (IEA) ?
heat shock protein binding (IEA) ?
unfolded protein binding (IEA) ?
3e-17

BLAST

Cluster Pair #12: 8 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF14_0563 ?
DEAD-box RNA helicase, putative

nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
** also with: FBgn0001942, clust.pair #12
FBgn0037573 ?
translation initiation factor activity ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
translational initiation ?
eukaryotic translation initiation factor 4F complex ?
0

BLAST
PF14_0563 ?
DEAD-box RNA helicase, putative

nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
** also with: FBgn0037573, clust.pair #12
FBgn0001942 ?
RNA cap binding ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
larval development (sensu Insecta) ?
RNA helicase activity ?
mRNA binding ?
translation initiation factor activity ?
ATP binding (IEA) ?
nucleus ?
cytosol ?
DNA unwinding ?
translational initiation ?
imaginal disc growth ?
dorsal/ventral axis specification ?
eukaryotic translation initiation factor 4F complex ?
single-stranded DNA-dependent ATP-dependent DNA helicase activity ?
0

BLAST
PFL1975c ?
hypothetical protein, conserved

FBgn0034274 ?
cell proliferation (IEA) ?
5e-11

BLAST
PF14_0542 ?
hypothetical protein, conserved

FBgn0035415 ?
3e-06

BLAST
PF14_0587 ?
hypothetical protein

nucleus (IEA) ?
mRNA processing (IEA) ?
FBgn0031493 ?
nuclear mRNA splicing, via spliceosome ?
spliceosome complex ?
snRNP U2 ?
0

BLAST
PFI0930c ?
Nucleosome assembly protein

nucleus (IEA) ?
nucleosome assembly (IEA) ?
FBgn0014879 ?
nucleus ?
DNA replication (IEA) ?
nucleosome assembly (IEA) ?
spermatogenesis (IEA) ?
phosphatase inhibitor activity (IEA) ?
cyclin binding ?
6e-23

BLAST
MAL13P1.172 ?
hypothetical protein, conserved

FBgn0039136 ?
3e-25

BLAST
PFI1435w ?
RNA binding function, putative

nucleic acid binding (IEA) ?
FBgn0037701 ?
nucleotide binding (IEA) ?
mRNA binding ?
0.003

BLAST

Cluster Pair #13: 5 gene pairs.

P.falciparumD.melanogasterBlast evalue
PFB0220w ?
UbiE-like methlytransferase, putative

mitochondrion ?
methyltransferase activity (IEA) ?
S-adenosylmethionine-dependent methyltransferase activity (IEA) ?
coenzyme biosynthesis (IEA) ?
quinone cofactor methyltransferase activity ?
quinone cofactor biosynthesis ?
FBgn0030460 ?
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ?
S-adenosylmethionine-dependent methyltransferase activity (IEA) ?
0

BLAST
PF08_0093 ?
hypothetical protein

binding (IEA) ?
transport (IEA) ?
membrane (IEA) ?
FBgn0033391 ?
carrier activity ?
binding (IEA) ?
mitochondrial membrane ?
mitochondrial inner membrane ?
mitochondrial transport ?
folic acid transporter activity ?
folic acid transport ?
1e-08

BLAST
PFE1265w ?
G-protein coupled receptor, putative

G-protein coupled receptor activity ?
integral to plasma membrane ?
G-protein coupled receptor protein signaling pathway ?
FBgn0027498 ?
G-protein coupled receptor activity ?
G-protein coupled receptor protein signaling pathway ?
integral to membrane (IEA) ?
8e-20

BLAST
PFE0435c ?
single-strand binding protein, putative

nucleic acid binding (IEA) ?
single-stranded DNA binding ?
DNA replication (IEA) ?
apicoplast ?
FBgn0010438 ?
mitochondrial genome maintenance ?
mitochondrial chromosome ?
single-stranded DNA binding ?
mitochondrion ?
DNA replication (IEA) ?
DNA repair (IEA) ?
4e-12

BLAST
PFE1125w ?
50S ribosomal subunit protein L17, putative

structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrial large ribosomal subunit ?
ribosome (IEA) ?
protein biosynthesis ?
FBgn0035122 ?
structural constituent of ribosome ?
mitochondrial large ribosomal subunit ?
protein biosynthesis ?
0.023

BLAST

Cluster Pair #14: 2 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF13_0174 ?
P. falciparum homologue of human mbp-1 interacting protein-2a%3B putative

intracellular transporter activity (IEA) ?
intracellular (IEA) ?
transport (IEA) ?
ER to Golgi transport ?
vesicle-mediated transport ?
FBgn0036573 ?
intracellular transporter activity (IEA) ?
intracellular (IEA) ?
ER to Golgi transport (IEA) ?
cell proliferation (IEA) ?
transcription regulator activity (IEA) ?
6e-22

BLAST
PF14_0243 ?
dynein-associated protein, putative

microtubule motor activity ?
cytoskeleton ?
microtubule-based movement ?
FBgn0036195 ?
motor activity ?
structural constituent of cytoskeleton (IEA) ?
cytoplasmic dynein complex ?
microtubule associated complex ?
RNA localization (IEA) ?
intracellular protein transport (IEA) ?
microtubule-based movement ?
cell cycle (IEA) ?
vesicle-mediated transport (IEA) ?
ATPase activity, coupled ?
0

BLAST

Cluster Pair #15: 11 gene pairs.

P.falciparumD.melanogasterBlast evalue
PFB0635w ?
T-complex protein 1, putative

protein binding (IEA) ?
ATP binding (IEA) ?
protein folding ?
ATPase activity, coupled ?
cellular protein metabolism (IEA) ?
unfolded protein binding (IEA) ?
FBgn0033342 ?
ATP binding (IEA) ?
chaperonin-containing T-complex ?
protein folding ?
ATPase activity, coupled ?
unfolded protein binding (IEA) ?
0

BLAST
PF10_0155 ?
enolase

phosphopyruvate hydratase complex ?
phosphopyruvate hydratase activity ?
gluconeogenesis ?
glycolysis ?
FBgn0000579 ?
phosphopyruvate hydratase complex (IEA) ?
phosphopyruvate hydratase activity ?
glycolysis ?
0

BLAST
PF14_0023 ?
hypothetical protein, conserved

membrane ?
FBgn0031227 ?
6e-09

BLAST
PF08_0096 ?
RNA helicase, putative

nucleic acid binding (IEA) ?
RNA helicase activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
FBgn0003970 ?
nucleic acid binding (IEA) ?
RNA helicase activity ?
ATP binding (IEA) ?
mRNA polyadenylylation ?
pole cell fate determination ?
oocyte fate determination (sensu Insecta) ?
oocyte anterior/posterior axis determination ?
pole plasm assembly ?
pole plasm RNA localization ?
ATP-dependent helicase activity ?
intracellular mRNA localization ?
oogenesis (sensu Insecta) ?
polar granule ?
karyosome formation ?
pole plasm ?
regulation of oskar mRNA translation ?
positive regulation of oskar mRNA translation ?
dorsal appendage formation ?
germ-line cyst formation ?
0

BLAST
PF14_0324 ?
hypothetical protein, conserved

FBgn0024352 ?
protein folding ?
protein complex assembly (IEA) ?
response to stress (IEA) ?
defense response (IEA) ?
unfolded protein binding ?
0

BLAST
PFC0271c ?
glutaredoxin, putative

electron transport (IEA) ?
response to oxidative stress ?
electron carrier activity (IEA) ?
glutathione disulfide oxidoreductase activity ?
cell redox homeostasis (IEA) ?
FBgn0036820 ?
2e-12

BLAST
PF11_0258 ?
co-chaperone GrpE, putative

adenyl-nucleotide exchange factor activity (IEA) ?
protein binding (IEA) ?
mitochondrion ?
mitochondrial matrix ?
protein folding (IEA) ?
mitochondrial matrix protein import ?
protein homodimerization activity (IEA) ?
unfolded protein binding ?
chaperone binding (IEA) ?
FBgn0014877 ?
adenyl-nucleotide exchange factor activity (IEA) ?
mitochondrion ?
mitochondrial matrix ?
protein folding ?
protein targeting to mitochondrion ?
protein homodimerization activity (IEA) ?
unfolded protein binding ?
chaperone binding (IEA) ?
1e-28

BLAST
PF07_0085 ?
ferrodoxin reductase-like protein

electron transport ?
electron carrier activity ?
disulfide oxidoreductase activity ?
oxidoreductase activity (IEA) ?
FBgn0025628 ?
electron transport (IEA) ?
ferredoxin metabolism (IEA) ?
oxygen and reactive oxygen species metabolism (IEA) ?
defense response (IEA) ?
disulfide oxidoreductase activity (IEA) ?
0

BLAST
PFL1425w ?
t-complex protein 1, gamma subunit, putative

protein binding (IEA) ?
ATP binding ?
chaperonin-containing T-complex ?
protein folding ?
cellular protein metabolism (IEA) ?
unfolded protein binding ?
FBgn0015019 ?
ATP binding (IEA) ?
cytoplasm ?
chaperonin-containing T-complex ?
protein folding ?
ATPase activity, coupled ?
unfolded protein binding ?
0

BLAST
PFA0145c ?
aspartyl-tRNA synthetase

nucleic acid binding (IEA) ?
tRNA ligase activity (IEA) ?
aspartate-tRNA ligase activity ?
ATP binding (IEA) ?
cytoplasm (IEA) ?
tRNA aminoacylation for protein translation (IEA) ?
aspartyl-tRNA aminoacylation ?
FBgn0002069 ?
mRNA binding (IEA) ?
aspartate-tRNA ligase activity ?
ATP binding (IEA) ?
cytoplasm (IEA) ?
aspartyl-tRNA aminoacylation ?
growth ?
0

BLAST
PFC0900w ?
T-complex protein 1 epsilon subunit, putative

protein binding (IEA) ?
ATP binding (IEA) ?
chaperonin-containing T-complex ?
protein folding ?
cellular protein metabolism (IEA) ?
unfolded protein binding ?
FBgn0010621 ?
ATP binding (IEA) ?
chaperonin-containing T-complex ?
protein folding ?
ATPase activity, coupled ?
unfolded protein binding ?
0

BLAST

Cluster Pair #16: 6 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF13_0042 ?
fork head domain protein, putative

protein binding ?
nucleus ?
FBgn0038640 ?
anion exchanger adaptor activity ?
0.005

BLAST
PFL2020c ?
hypothetical protein

electron transport (IEA) ?
electron carrier activity (IEA) ?
FBgn0033814 ?
protein modification (IEA) ?
electron carrier activity (IEA) ?
protein disulfide oxidoreductase activity (IEA) ?
glucosidase activity (IEA) ?
flavin-linked sulfhydryl oxidase activity ?
3e-06

BLAST
PF10_0122 ?
phosphoglucomutase, putative

carbohydrate metabolism (IEA) ?
intramolecular transferase activity, phosphotransferases (IEA) ?
FBgn0033377 ?
phosphomannomutase activity ?
monosaccharide metabolism (IEA) ?
0

BLAST
PF13_0358 ?
mitochondrial import inner membrane translocase, putative

mitochondrial intermembrane space ?
protein targeting to mitochondrion ?
protein translocase activity ?
mitochondrial intermembrane space protein transporter complex (IEA) ?
mitochondrial inner membrane protein import (IEA) ?
FBgn0030480 ?
mitochondrial inner membrane presequence translocase complex ?
protein targeting to mitochondrion ?
protein transport ?
protein translocase activity ?
mitochondrial intermembrane space protein transporter complex (IEA) ?
mitochondrial inner membrane protein import (IEA) ?
4e-09

BLAST
PFL0210c ?
eukaryotic initiation factor 5a, putative

nucleic acid binding (IEA) ?
translation initiation factor activity ?
translational initiation ?
FBgn0034967 ?
translation initiation factor activity ?
cytosol ?
translational initiation ?
salivary gland cell death ?
translation regulator activity ?
autophagic cell death ?
0

BLAST
PFL2075c ?
hypothetical protein, conserved

nucleic acid binding (IEA) ?
nucleus (IEA) ?
zinc ion binding (IEA) ?
FBgn0035520 ?
5e-15

BLAST

Cluster Pair #17: 16 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF14_0688 ?
hypothetical protein, conserved

FBgn0037550 ?
4e-21

BLAST
MAL8P1.19 ?
hypothetical protein, conserved

nucleic acid binding (IEA) ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
apicoplast ?
** also with: FBgn0032919, clust.pair #17
FBgn0036104 ?
nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
helicase activity ?
ATP binding (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
1e-27

BLAST
MAL8P1.19 ?
hypothetical protein, conserved

nucleic acid binding (IEA) ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
apicoplast ?
** also with: FBgn0036104, clust.pair #17
FBgn0032919 ?
nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
metal ion transport (IEA) ?
metal ion binding (IEA) ?
7e-27

BLAST
PF14_0546 ?
hypothetical protein, conserved

FBgn0030520 ?
nucleic acid binding (IEA) ?
translation elongation factor activity (IEA) ?
protein biosynthesis (IEA) ?
apoptosis (IEA) ?
induction of apoptosis (IEA) ?
translation factor activity, nucleic acid binding (IEA) ?
protein metabolism (IEA) ?
0.028

BLAST
PF11_0090 ?
hypothetical protein

intracellular (IEA) ?
nucleolus (IEA) ?
cell proliferation (IEA) ?
FBgn0032138 ?
nucleic acid binding (IEA) ?
mRNA binding (IEA) ?
structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
nucleolus (IEA) ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
protein complex assembly (IEA) ?
cell proliferation (IEA) ?
rRNA metabolism (IEA) ?
protein metabolism (IEA) ?
0

BLAST
PF13_0286 ?
methyltransferase, putative

rRNA processing ?
RNA methyltransferase activity ?
FBgn0030720 ?
nucleic acid binding (IEA) ?
nucleolus ?
rRNA processing ?
rRNA methyltransferase activity ?
rRNA metabolism (IEA) ?
0

BLAST
PFA0330w ?
pfAARP2 protein

plasma membrane ?
FBgn0036686 ?
0

BLAST
PFB0630c ?
hypothetical protein

FBgn0032678 ?
4e-08

BLAST
MAL7P1.24 ?
hypothetical protein, conserved

intracellular (IEA) ?
FBgn0025366 ?
0

BLAST
PF08_0054 ?
heat shock 70 kDa protein

ATP binding (IEA) ?
response to unfolded protein ?
response to heat ?
FBgn0001219 ?
embryonic development (sensu Insecta) ?
ATP binding (IEA) ?
nucleus ?
mitochondrion ?
protein folding ?
protein complex assembly (IEA) ?
defense response (IEA) ?
neurotransmitter secretion ?
nervous system development ?
axon guidance ?
axonal fasciculation ?
response to heat ?
vesicle-mediated transport ?
ATPase activity ?
protein refolding ?
synaptic vesicle transport (IEA) ?
unfolded protein binding ?
0

BLAST
PFC0005w ?
PfEMP1

receptor activity (IEA) ?
glycosaminoglycan binding (IEA) ?
pathogenesis (IEA) ?
integral to membrane (IEA) ?
FBgn0025140 ?
nucleic acid binding (IEA) ?
RNA helicase activity ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
nucleus ?
nucleolus ?
nucleobase, nucleoside, nucleotide and nucleic acid metabolism (IEA) ?
0.013

BLAST
PFC0100c ?
regulatory protein, putative

FBgn0030365 ?
cytosol ?
Golgi organization and biogenesis ?
signal transduction (IEA) ?
0

BLAST
PF11_0418 ?
hypothetical protein

chromatin (IEA) ?
chromatin binding (IEA) ?
nucleus (IEA) ?
chromatin assembly or disassembly (IEA) ?
** also with: FBgn0039019, clust.pair #17
FBgn0030082 ?
chromatin (IEA) ?
chromatin binding ?
nucleus (IEA) ?
chromatin assembly or disassembly (IEA) ?
regulation of transcription from RNA polymerase II promoter (IEA) ?
0.006

BLAST
PF11_0418 ?
hypothetical protein

chromatin (IEA) ?
chromatin binding (IEA) ?
nucleus (IEA) ?
chromatin assembly or disassembly (IEA) ?
** also with: FBgn0030082, clust.pair #17
FBgn0039019 ?
chromatin (IEA) ?
chromatin binding ?
nucleus (IEA) ?
chromatin assembly or disassembly (IEA) ?
regulation of transcription from RNA polymerase II promoter (IEA) ?
0.013

BLAST
PF14_0437 ?
helicase, truncated, putative

nucleic acid binding ?
helicase activity ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
FBgn0003261 ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
mRNA binding ?
ATP-dependent RNA helicase activity ?
protein binding ?
ATP binding (IEA) ?
nucleus ?
ATP-dependent helicase activity ?
RNA interference ?
antimicrobial humoral response ?
8e-39

BLAST
PFE0300c ?
60S ribosomal subunit protein L24, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
large ribosomal subunit ?
FBgn0037899 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
ribosome biogenesis and assembly ?
7e-39

BLAST

Cluster Pair #18: 10 gene pairs.

P.falciparumD.melanogasterBlast evalue
PFD0470c ?
replication factor a protein, putative

nucleic acid binding (IEA) ?
DNA replication factor A complex ?
DNA replication ?
DNA-dependent DNA replication ?
FBgn0010173 ?
single-stranded DNA binding ?
nucleus ?
DNA replication factor A complex ?
DNA-dependent DNA replication ?
4.00001e-40

BLAST
PFB0465c ?
hypothetical protein

membrane ?
FBgn0033028 ?
cation transport (IEA) ?
monocarboxylic acid transporter activity ?
9e-08

BLAST
PF14_0133 ?
ATP-dependent transporter, putative

ATP binding (IEA) ?
transport ?
membrane ?
ATPase activity (IEA) ?
apicoplast ?
ATPase activity, coupled to transmembrane movement of substances ?
FBgn0030321 ?
transporter activity ?
ATP binding (IEA) ?
transport (IEA) ?
ATPase activity, coupled to transmembrane movement of substances ?
ATP-binding cassette (ABC) transporter complex ?
1e-07

BLAST
PFB0840w ?
replication factor C, subunit 2

nucleotide binding (IEA) ?
DNA binding (IEA) ?
ATP binding (IEA) ?
DNA replication factor C complex ?
DNA replication ?
nucleoside-triphosphatase activity (IEA) ?
protein complex (IEA) ?
FBgn0030871 ?
DNA binding ?
DNA-directed DNA polymerase activity (IEA) ?
ATP binding (IEA) ?
DNA replication factor C complex ?
DNA replication ?
DNA repair (IEA) ?
nucleoside-triphosphatase activity (IEA) ?
0

BLAST
PF11_0361 ?
hypothetical protein

membrane ?
FBgn0031662 ?
integral to membrane ?
0.042

BLAST
PF10_0316 ?
phosphatidyl inositol glycan, class A, putative

catalytic activity ?
GPI anchor biosynthesis ?
biosynthesis (IEA) ?
membrane ?
FBgn0034270 ?
polysaccharide metabolism (IEA) ?
GPI anchor biosynthesis ?
phosphatidylinositol N-acetylglucosaminyltransferase activity ?
integral to endoplasmic reticulum membrane ?
0

BLAST
PF14_0053 ?
ribonucleotide reductase small subunit

ribonucleoside-diphosphate reductase activity ?
DNA replication ?
deoxyribonucleoside diphosphate metabolism (IEA) ?
FBgn0011704 ?
ribonucleoside-diphosphate reductase activity ?
ribonucleoside-diphosphate reductase complex ?
purine base metabolism (IEA) ?
pyrimidine base metabolism (IEA) ?
DNA replication ?
deoxyribonucleoside diphosphate metabolism (IEA) ?
0

BLAST
MAL13P1.326 ?
ferrochelatase, putative

ferrochelatase activity ?
heme biosynthesis ?
ferrous iron binding ?
FBgn0024891 ?
ferrochelatase activity ?
mitochondrial inner membrane ?
protoporphyrinogen IX biosynthesis ?
5e-19

BLAST
PF14_0376 ?
hypothetical protein

membrane ?
FBgn0028507 ?
3e-31

BLAST
PFE0270c ?
DNA repair protein, putative

damaged DNA binding ?
ATP binding (IEA) ?
DNA metabolism (IEA) ?
DNA repair ?
mismatch repair (IEA) ?
FBgn0036486 ?
damaged DNA binding (IEA) ?
ATP binding (IEA) ?
DNA repair ?
mismatch repair (IEA) ?
postreplication repair ?
0

BLAST

Cluster Pair #19: 39 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF11_0043 ?
60S acidic ribosomal protein p1, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
translational elongation (IEA) ?
large ribosomal subunit ?
FBgn0002593 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
translational elongation ?
1e-10

BLAST
PF08_0019 ?
guanine nucleotide-binding protein, putative

protein kinase C binding ?
heterotrimeric G-protein complex ?
G-protein coupled receptor protein signaling pathway ?
FBgn0020618 ?
protein kinase C binding ?
protein targeting (IEA) ?
signal transduction (IEA) ?
0

BLAST
PF14_0083 ?
ribosomal protein S8e, putative

structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrion ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0039713 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF14_0448 ?
ribosomal protein S2, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
FBgn0004867 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF14_0125 ?
deoxyhypusine synthase

protein biosynthesis ?
hypusine biosynthesis from peptidyl-lysine ?
membrane ?
spermidine catabolism to deoxyhypusine, using deoxyhypusine synthase ?
FBgn0035854 ?
hypusine biosynthesis from peptidyl-lysine ?
spermidine catabolism to deoxyhypusine, using deoxyhypusine synthase ?
7.00649e-43

BLAST
PF13_0316 ?
40S ribosomal protein S13

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0010265 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF10_0326 ?
hypothetical protein

FBgn0034908 ?
4e-21

BLAST
PF07_0043 ?
60S ribosomal protein L34-a, putative

structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis (IEA) ?
FBgn0037686 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
1e-24

BLAST
PF14_0296 ?
ribosomal protein L14, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
apicoplast ?
FBgn0017579 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic ribosome (sensu Eukaryota) ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0.005

BLAST
PFE0750c ?
hypothetical protein, conserved

nucleic acid binding (IEA) ?
FBgn0037220 ?
nucleotide binding (IEA) ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
mRNA binding ?
nucleus ?
zinc ion binding (IEA) ?
2e-06

BLAST
PF08_0039 ?
ribosomal protein, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0015288 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
7e-15

BLAST
PFD0180c ?
CGI-201 protein, short form

spliceosome assembly ?
RNA binding ?
intracellular (IEA) ?
RNA processing (IEA) ?
FBgn0000377 ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
nuclear mRNA splicing, via spliceosome ?
nucleus ?
spliceosome complex ?
neuroblast proliferation ?
central nervous system development ?
peripheral nervous system development ?
Malpighian tubule morphogenesis ?
nuclear speck ?
0

BLAST
PFB0885w ?
40S ribosomal protein S30, putative

structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrion ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0038834 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis (IEA) ?
1e-15

BLAST
PF08_0075 ?
60S ribosomal protein L13, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0011272 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
3e-28

BLAST
PFC0200w ?
60S Ribosomal protein L44, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0031980 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
3e-28

BLAST
PF10_0264 ?
40S ribosomal protein, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
FBgn0003517 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
protein metabolism (IEA) ?
0

BLAST
PF10_0043 ?
ribosomal protein L13, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
large ribosomal subunit (IEA) ?
FBgn0037351 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PFC0290w ?
40S ribosomal protein S23, putative

nucleic acid binding (IEA) ?
structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
FBgn0033912 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF10_0272 ?
ribosomal protein L3, putative

structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrion ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0020910 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic ribosome (sensu Eukaryota) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PFE0975c ?
40S ribosomal subunit protein S24, putative

structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis (IEA) ?
FBgn0034751 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
5e-31

BLAST
PFE1005w ?
40S ribosomal subunit protein S9, putative

RNA binding (IEA) ?
structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis (IEA) ?
small ribosomal subunit (IEA) ?
FBgn0010408 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF11_0260 ?
ribosomal protein L35, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
large ribosomal subunit ?
FBgn0029785 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
2e-08

BLAST
PF11_0106 ?
60S Ribosomal protein L36, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
membrane ?
FBgn0002579 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
4e-12

BLAST
PF11_0313 ?
ribosomal phosphoprotein P0

structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrion ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
translational elongation (IEA) ?
ribosome biogenesis and assembly (IEA) ?
FBgn0000100 ?
mRNA binding (IEA) ?
structural constituent of ribosome ?
DNA-(apurinic or apyrimidinic site) lyase activity ?
nucleus ?
cytoplasm ?
cytosolic ribosome (sensu Eukaryota) ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
DNA repair ?
protein biosynthesis ?
translational elongation (IEA) ?
ribosome biogenesis and assembly (IEA) ?
0

BLAST
PFB0445c ?
helicase, putative

nucleic acid binding (IEA) ?
ATP-dependent RNA helicase activity ?
helicase activity (IEA) ?
ATP binding (IEA) ?
ATP-dependent helicase activity (IEA) ?
FBgn0014189 ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
nuclear mRNA splicing, via spliceosome ?
RNA helicase activity ?
ATP-dependent RNA helicase activity ?
ATP binding (IEA) ?
nucleus ?
spliceosome complex ?
mRNA-nucleus export ?
RNA splicing factor activity, transesterification mechanism ?
0

BLAST
PF14_0627 ?
ribosomal protein S3, putative

nucleic acid binding (IEA) ?
structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
FBgn0002622 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
DNA-(apurinic or apyrimidinic site) lyase activity ?
nucleus ?
cytoplasm ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
DNA repair ?
protein biosynthesis ?
purine-specific oxidized base lesion DNA N-glycosylase activity ?
nuclear matrix ?
0

BLAST
PF14_0585 ?
ribosomal protein S28e, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0030136 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis (IEA) ?
2e-09

BLAST
MAL13P1.209 ?
60S ribosomal subunit porotein L18, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0035753 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF07_0088 ?
40S ribosomal protein S5, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
** also with: FBgn0002590, clust.pair #19
FBgn0038277 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF07_0088 ?
40S ribosomal protein S5, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
small ribosomal subunit (IEA) ?
** also with: FBgn0038277, clust.pair #19
FBgn0002590 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF10_0217 ?
pre-mRNA splicing factor, putative

nucleic acid binding (IEA) ?
mitochondrion ?
RNA splicing ?
RNA splicing factor activity, transesterification mechanism ?
FBgn0004587 ?
nucleotide binding (IEA) ?
regulation of alternative nuclear mRNA splicing, via spliceosome ?
nuclear mRNA splicing, via spliceosome ?
mRNA binding ?
protein binding ?
nucleus ?
spliceosome complex (IEA) ?
mRNA splice site selection ?
nuclear speck ?
RNA splicing factor activity, transesterification mechanism ?
omega speckle ?
regulation of nuclear mRNA splicing, via spliceosome ?
3e-22

BLAST
PFE0845c ?
60S ribosomal subunit protein L8, putative

nucleic acid binding (IEA) ?
structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
large ribosomal subunit ?
FBgn0024939 ?
mRNA binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF13_0129 ?
ribosomal protein L6 homologue, putative

RNA binding ?
structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
large ribosomal subunit ?
FBgn0015756 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF13_0049 ?
60S ribosomal protein L24, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0032518 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
1e-08

BLAST
PFC0400w ?
60S Acidic ribosomal protein P2

structural constituent of ribosome (IEA) ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
translational elongation ?
large ribosomal subunit ?
FBgn0003274 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic ribosome (sensu Eukaryota) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
translational elongation ?
3e-11

BLAST
PF11_0065 ?
ribosomal protein S4, putative

RNA binding ?
structural constituent of ribosome ?
intracellular (IEA) ?
mitochondrion ?
ribosome (IEA) ?
protein biosynthesis ?
small ribosomal subunit ?
FBgn0011284 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
ribosome ?
cytosolic small ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PF07_0079 ?
60S ribosomal protein L11a, putative

structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
FBgn0013325 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
protein binding ?
ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST
PFL0310c ?
eukaryotic translation initiation factor 3 subunit 8, putative

translation initiation factor activity ?
eukaryotic translation initiation factor 3 complex ?
translational initiation (IEA) ?
regulation of translational initiation ?
FBgn0034258 ?
translation initiation factor activity ?
cytosol ?
eukaryotic translation initiation factor 3 complex ?
translational initiation ?
0

BLAST
PFE0350c ?
60S ribosomal subunit protein L4%2FL1, putative

RNA binding ?
structural constituent of ribosome ?
intracellular (IEA) ?
ribosome (IEA) ?
protein biosynthesis ?
large ribosomal subunit ?
FBgn0003279 ?
nucleic acid binding (IEA) ?
structural constituent of ribosome ?
cytosolic large ribosomal subunit (sensu Eukaryota) ?
protein biosynthesis ?
0

BLAST

Cluster Pair #20: 7 gene pairs.

P.falciparumD.melanogasterBlast evalue
PF14_0667 ?
hypothetical protein

FBgn0036685 ?
0.005

BLAST
PFC0515c ?
hypothetical protein

FBgn0024352 ?
protein folding ?
protein complex assembly (IEA) ?
response to stress (IEA) ?
defense response (IEA) ?
unfolded protein binding ?
7e-06

BLAST
PFD0795w ?
hypothetical protein

FBgn0037376 ?
histone acetyltransferase activity ?
chromatin assembly or disassembly (IEA) ?
4e-11

BLAST
PF07_0105 ?
exonuclease i, putative

DNA binding (IEA) ?
nuclease activity (IEA) ?
nucleus ?
DNA repair (IEA) ?
mismatch repair ?
DNA recombination ?
5'-3' exonuclease activity ?
FBgn0015553 ?
nucleic acid binding (IEA) ?
DNA binding (IEA) ?
nuclease activity ?
DNA repair (IEA) ?
exodeoxyribonuclease I activity ?
4e-26

BLAST
PFL0150w ?
origin recognition complex 1 protein

nucleotide binding (IEA) ?
DNA replication origin binding ?
ATP binding (IEA) ?
DNA replication initiation ?
nucleoside-triphosphatase activity (IEA) ?
FBgn0022772 ?
regulation of progression through cell cycle (IEA) ?
DNA binding ?
DNA replication origin binding (IEA) ?
ATP binding (IEA) ?
nucleus ?
nuclear origin of replication recognition complex ?
DNA-dependent DNA replication ?
DNA replication initiation ?
chromatin silencing ?
nucleoside-triphosphatase activity (IEA) ?
0

BLAST
PFC0710w ?
inorganic pyrophosphatase, putative

magnesium ion binding (IEA) ?
inorganic diphosphatase activity (IEA) ?
cytoplasm (IEA) ?
phosphate metabolism (IEA) ?
metabolism ?
pyrophosphatase activity ?
FBgn0016687 ?
magnesium ion binding (IEA) ?
inorganic diphosphatase activity ?
nucleus ?
cytoplasm ?
chromatin remodeling ?
transcription ?
polyphosphate catabolism (IEA) ?
NURF complex ?
ecdysone receptor-mediated signaling pathway ?
nucleosome mobilization ?
9.99995e-41

BLAST
PFC0960c ?
hypothetical protein

FBgn0020503 ?
actin binding ?
structural constituent of cytoskeleton (IEA) ?
protein binding ?
Golgi apparatus ?
microtubule associated complex ?
spindle microtubule ?
cell cortex ?
protein targeting (IEA) ?
microtubule-based process ?
cellularization ?
microtubule binding ?
vesicle-mediated transport (IEA) ?
fusome ?
5e-11

BLAST