Supplementary material for Algorithms for computing parsimonious evolutionary scenarios for genome evolution, the last universal common ancestor and dominance of horizontal gene transfer in the evolution of prokaryotes Boris G. Mirkin, Trevor I. Fenner, Michael Y. Galperin, and Eugene V. Koonin All LUCA reconstruction, except for the last one, are for the genome-tree topology LUCA0.9 Total number of events, gains and losses are 13782 11481 2301 Total inconsistency = 12634 310 COGs number of species/inconsistency (number of events)/number of genes 26 1 44 aompkzyqvdrlbcefghsnujxitw AlaS [J] COG0013 Alanyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw ArgS [J] COG0018 Arginyl-tRNA synthetase 20 5 73 aom--zyqvdrlbc-f---nujxitw GatA [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases 20 5 34 aom--zyqvdrlbc-f---nujxitw GatB [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) 25 2 44 ao-pkzyqvdrlbcefghsnujxitw CysS [J] COG0215 Cysteinyl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw KsgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) 26 1 85 aompkzyqvdrlbcefghsnujxitw TufB [JE] COG0050 GTPases - translation elongation factors 26 1 75 aompkzyqvdrlbcefghsnujxitw GlnS [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases 26 1 58 aompkzyqvdrlbcefghsnujxitw HisS [J] COG0124 Histidyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw IleS [J] COG0060 Isoleucyl-tRNA synthetase 26 1 48 aompkzyqvdrlbcefghsnujxitw LeuS [J] COG0495 Leucyl-tRNA synthetase 26 1 55 aompkzyqvdrlbcefghsnujxitw Map [J] COG0024 Methionine aminopeptidase 26 1 48 aompkzyqvdrlbcefghsnujxitw MetG [J] COG0143 Methionyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw PheS [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit 26 1 46 aompkzyqvdrlbcefghsnujxitw PheT [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit 25 2 58 aompk-yqvdrlbcefghsnujxitw HemK [J] COG2890 Predicted rRNA or tRNA methylase 26 1 47 aompkzyqvdrlbcefghsnujxitw ProS [J] COG0442 Prolyl-tRNA synthetase 26 1 45 aompkzyqvdrlbcefghsnujxitw TruB [J] COG0130 Pseudouridine synthase 25 2 46 aompk-yqvdrlbcefghsnujxitw TruA [J] COG0101 Pseudouridylate synthase (tRNA psi55) 25 2 54 aompkzyqvdrlbcefghsn-jxitw SUA5 [J] COG0009 Putative translation factor (SUA5) 19 6 76 -o--kzyqvdrlbcefghsnuj---- TdcF [J] COG0251 Putative translation initiation inhibitor 26 1 47 aompkzyqvdrlbcefghsnujxitw RplA [J] COG0081 Ribosomal protein L1 26 1 49 aompkzyqvdrlbcefghsnujxitw RplJ [J] COG0244 Ribosomal protein L10 26 1 49 aompkzyqvdrlbcefghsnujxitw RplK [J] COG0080 Ribosomal protein L11 26 1 48 aompkzyqvdrlbcefghsnujxitw RplM [J] COG0102 Ribosomal protein L13 26 1 47 aompkzyqvdrlbcefghsnujxitw RplN [J] COG0093 Ribosomal protein L14 26 1 45 aompkzyqvdrlbcefghsnujxitw RplO [J] COG0200 Ribosomal protein L15 26 1 48 aompkzyqvdrlbcefghsnujxitw RplP [J] COG0197 Ribosomal protein L16/L10E 26 1 44 aompkzyqvdrlbcefghsnujxitw RplR [J] COG0256 Ribosomal protein L18 26 1 45 aompkzyqvdrlbcefghsnujxitw RplB [J] COG0090 Ribosomal protein L2 26 1 48 aompkzyqvdrlbcefghsnujxitw RplV [J] COG0091 Ribosomal protein L22 26 1 43 aompkzyqvdrlbcefghsnujxitw RplW [J] COG0089 Ribosomal protein L23 26 1 44 aompkzyqvdrlbcefghsnujxitw RplX [J] COG0198 Ribosomal protein L24 26 1 44 aompkzyqvdrlbcefghsnujxitw RpmC [J] COG0255 Ribosomal protein L29 26 1 46 aompkzyqvdrlbcefghsnujxitw RplC [J] COG0087 Ribosomal protein L3 22 5 39 aompkzyqvdrlb-efghsn-jx-t- RpmD [J] COG1841 Ribosomal protein L30/L7E 26 1 47 aompkzyqvdrlbcefghsnujxitw RplD [J] COG0088 Ribosomal protein L4 26 1 47 aompkzyqvdrlbcefghsnujxitw RplE [J] COG0094 Ribosomal protein L5 26 1 47 aompkzyqvdrlbcefghsnujxitw RplF [J] COG0097 Ribosomal protein L6 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsJ [J] COG0051 Ribosomal protein S10 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsK [J] COG0100 Ribosomal protein S11 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsL [J] COG0048 Ribosomal protein S12 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsM [J] COG0099 Ribosomal protein S13 26 1 50 aompkzyqvdrlbcefghsnujxitw RpsN [J] COG0199 Ribosomal protein S14 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsO [J] COG0184 Ribosomal protein S15P/S13E 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsQ [J] COG0186 Ribosomal protein S17 26 1 45 aompkzyqvdrlbcefghsnujxitw RpsS [J] COG0185 Ribosomal protein S19 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsB [J] COG0052 Ribosomal protein S2 26 1 44 aompkzyqvdrlbcefghsnujxitw RpsC [J] COG0092 Ribosomal protein S3 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsD [J] COG0522 Ribosomal protein S4 and related proteins 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsE [J] COG0098 Ribosomal protein S5 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsG [J] COG0049 Ribosomal protein S7 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsH [J] COG0096 Ribosomal protein S8 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsI [J] COG0103 Ribosomal protein S9 26 1 46 aompkzyqvdrlbcefghsnujxitw SerS [J] COG0172 Seryl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw ThrS [J] COG0441 Threonyl-tRNA synthetase 26 1 80 aompkzyqvdrlbcefghsnujxitw FusA [J] COG0480 Translation elongation and release factors (GTPases) 26 1 52 aompkzyqvdrlbcefghsnujxitw Efp [J] COG0231 Translation elongation factor P/translation initiation factor eIF-5A 26 1 49 aompkzyqvdrlbcefghsnujxitw InfB [J] COG0532 Translation initiation factor 2 (GTPase) 26 1 46 aompkzyqvdrlbcefghsnujxitw InfA [J] COG0361 Translation initiation factor IF-1 26 1 49 aompkzyqvdrlbcefghsnujxitw TrpS [J] COG0180 Tryptophanyl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw TyrS [J] COG0162 Tyrosyl-tRNA synthetase 26 1 45 aompkzyqvdrlbcefghsnujxitw ValS [J] COG0525 Valyl-tRNA synthetase 21 6 54 aom-kzy-vdrlbcefghsnuj-i-- Sun [J] COG0144 tRNA and rRNA cytosine-C5-methylases 26 1 46 aompkzyqvdrlbcefghsnujxitw RpoA [K] COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw RpoB [K] COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) 26 1 63 aompkzyqvdrlbcefghsnujxitw RpoC [K] COG0086 DNA-directed RNA polymerase beta' subunit/160 kD subunit (split gene in archaea and Syn) 24 3 38 aompkzyqvdrlbcefghsnujx-t- RpoZ [K] COG1758 DNA-directed RNA polymerase subunit K/omega 19 4 48 -o----yqvd-lbcefghsnuj-itw VacB [K] COG0557 Exoribonucleases 24 3 309 aompkzyqvdrlbcefghsnuj-i-w WecD [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases 14 6 22 aompkzy-vd-lbc------u---t- - [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP 26 1 48 aompkzyqvdrlbcefghsnujxitw NusG [K] COG0250 Transcription antiterminator 26 1 61 aompkzyqvdrlbcefghsnujxitw Exo [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 25 2 75 aompkzyqvdrlbcefghsnu-xitw HolB [L] COG0470 ATPase involved in DNA replication 23 2 63 ao-p--yqvdrlbcefghsnujxitw GyrA [L] COG0188 DNA gyrase (topoisomerase II) A subunit 23 2 62 ao-p--yqvdrlbcefghsnujxitw GyrB [L] COG0187 DNA gyrase (topoisomerase II) B subunit 18 5 34 -o----yqvd-lbcefghsn-jxit- MutL [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) 26 1 47 aompkzyqvdrlbcefghsnujxitw DnaN [L] COG0592 DNA polymerase III beta subunit 18 6 27 aompkzyqvdrlbcefg-------t- SbcD [L] COG0420 DNA repair exonuclease 22 5 47 aompkzyqv-rlb-efghsnuj-it- Ada [L] COG0350 Methylated DNA-protein cysteine methyltransferase 19 6 42 -o-p--yqvd-lbcefghsn-jxit- MutS [L] COG0249 MutS-like ATPases involved in mismatch repair, family 2 24 3 198 aomp-zyqvdrlbcefghsnujxit- MutT [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes 25 2 47 aompkzyqvdrlbcefghsnujxit- Nth [L] COG0177 Predicted EndoIII-related endonuclease 26 1 62 aompkzyqvdrlbcefghsnujxitw RecA [L] COG0468 RecA/RadA recombinase 25 2 39 aompkzyqvdrlbcefghsnujxit- RnhB [L] COG0164 Ribonuclease HII 26 1 59 aompkzyqvdrlbcefghsnujxitw TopA [L] COG0550 Topoisomerase IA 22 4 55 aompkzyqvdr-bcefghsnujx--- Mrp [D] COG0489 ATPases involved in chromosome partitioning 19 6 41 aompk-yqvdrlbc-f--sn-j--tw Smc [D] COG1196 Chromosome segregation ATPases 18 7 32 -om-k-yqvdr-bcefghsnuj---- CrcB [D] COG0239 Integral membrane protein possibly involved in chromosome condensation 26 1 79 aompkzyqvdrlbcefghsnujxitw MesJ [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control 26 1 80 aompkzyqvdrlbcefghsnujxitw GroL [O] COG0459 Chaperonin GroEL (HSP60 family) 20 7 57 aom-k-y-vdrlbcefghsn-jx-t- GrxC [O] COG0695 Glutaredoxin and related proteins 24 3 82 aompkzyqvdrlbcefghsnujx-t- HflC [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs 26 1 47 aompkzyqvdrlbcefghsnujxitw QRI7 [O] COG0533 Metal-dependent proteases with possible chaperone activity 24 3 54 aompkzyqvdrlbcefghs-ujxit- AhpC [O] COG0450 Peroxiredoxin 18 7 40 -o-p-zyqvdr-bcefghsnuj---- Bcp [O] COG1225 Peroxiredoxin 20 6 72 aompkzyqv-r-b-efghs-ujx-t- HslV [O] COG0638 Proteasome protease subunit 26 1 239 aompkzyqvdrlbcefghsnujxitw TrxA [OC] COG0526 Thiol-disulfide isomerase and thioredoxins 26 1 76 aompkzyqvdrlbcefghsnujxitw TrxB [O] COG0492 Thioredoxin reductase 21 4 81 -om---yqvdrlbcefghsnujxit- DegQ [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain 23 4 43 -ompkzyqvdrlbcefghsnuj-it- GlmS [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains 25 2 238 aompkzyqvdrlbcefghsnujx-tw WcaA [M] COG0463 Glycosyltransferases involved in cell wall biogenesis 22 5 162 aompk-yqvdrlbcefghsnuj--t- WcaG [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 19 8 56 aompkzyq-dr-bc-f-hsnuj--t- GCD1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylases involved in lipopolysaccharide biosynthesis/translation initiation factor eIF2B subunits 24 3 260 aompkzyqvdrlbcefghsnujx-t- RfaG [M] COG0438 Predicted glycosyltransferases 26 1 46 aompkzyqvdrlbcefghsnujxitw SecY [N] COG0201 Preprotein translocase subunit SecY 25 2 68 aompkzyqvdrlbcefghsnujxit- LepB [N] COG0681 Signal peptidase I 26 1 44 aompkzyqvdrlbcefghsnujxitw Ffh [N] COG0541 Signal recognition particle GTPase 26 1 46 aompkzyqvdrlbcefghsnujxitw FtsY [N] COG0552 Signal recognition particle GTPase 24 3 89 aompkzyqvdrlbcefgh-nuj-itw ZntA [P] COG2217 Cation transport ATPases 16 8 30 ao-p-zyqvd-lbc-f-h-nu----w CopZ [P] COG2608 Copper chaperone 17 8 50 -om-k-yq-d-lbcefghsnu--i-- CitT [P] COG0471 Di- and tricarboxylate transporters 22 5 60 a-mpkzyq-drlbcefghsnujx-t- KefB [P] COG0475 Kef-type K+ transport systems, membrane components 24 2 79 aompkzyqvdrlbcefghsnujx--w Kch [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component 18 9 50 aompk-y-vdr-b-efgh-nuj-i-- PitA [P] COG0306 Phosphate/sulphate permeases 21 6 36 aom-kzyqvdrlbcefgh--ujx-t- MMT1 [P] COG0053 Predicted Co/Zn/Cd cation transporters 14 9 23 -om-kzyqvdr---ef---nu---t- - [P] COG0428 Predicted divalent heavy-metal cations transporter 21 6 95 aomp--yq-drlbcefghsnujx-t- PspE [P] COG0607 Rhodanese-related sulfurtransferases 22 5 49 -omp-zyq-drlbcefghsnujxit- SodA [P] COG0605 Superoxide dismutase 20 6 37 aom-kzyqvd-lbcefgh-nu---tw TrkG [P] COG0168 Trk-type K+ transport systems, membrane components 20 7 334 aom-k-y-vdrlbcefghs-ujx-t- CheY [T] COG0784 CheY-like receiver domains 22 5 549 aom---yqvdrlbcefghsnujxit- BaeS [T] COG0642 Sensory transduction histidine kinases 22 4 51 aomp-zyqvdrlbcefghsnujx--- GltA [C] COG0372 Citrate synthase 23 4 97 aomp-zyqvdrlbcefghsn-jxi-w Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes 26 1 53 aompkzyqvdrlbcefghsnujxitw AtpE [C] COG0636 F0F1-type ATP synthase c subunit/Archaeal/vacuolar-type H+-ATPase subunit K 19 5 36 aompkzyqvdr--cef--snujx--- NuoI [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) 21 6 33 ao-pkzyqvdrlbcefghs--j--tw GlpK [C] COG0554 Glycerol kinase 22 5 41 -ompkzyq-dr-bcefghsnujxi-w Ppa [C] COG0221 Inorganic pyrophosphatase 17 8 28 ao-p-zyqvdrlbcef-h--uj---- Icd [C] COG0538 Isocitrate dehydrogenases 23 4 45 aomp-zyqvdrlbce-ghs-ujxitw Mdh [C] COG0039 Malate/lactate dehydrogenases 18 6 26 ao-pkzyqvdr--cef--snujx--- NuoB [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoC [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoD [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 19 6 37 ao----yqv-rlb-efgh-nujxitw IscU [C] COG0822 NifU homologs involved in Fe-S cluster formation 18 8 94 -o-p-zyqvdrlbcefg-s-uj--t- Tas [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) 18 8 63 aompkzyqv-rlbce-g---uj--t- PorA [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit 18 8 60 aompkzyqv-rlbce-g---uj--t- PorB [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit 21 6 41 aomp-zyq-dr-bcefghsnujxi-- FrdB [C] COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein 23 4 54 aomp-zyqvdrlbcefghsnujxi-- SdhA [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunits 21 6 38 aomp-zyq-dr-bcefghsnujxi-- SucD [C] COG0074 Succinyl-CoA synthetase alpha subunit 21 6 34 aomp-zyq-dr-bcefghsnujxi-- SucC [C] COG0045 Succinyl-CoA synthetase beta subunit 25 2 43 aompkzyqvdrlbcefghsnuj-itw Pgk [G] COG0126 3-phosphoglycerate kinase 23 4 48 aom-kzyqvdrlbcefghsnujx-t- SuhB [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family 25 2 51 aompkzyqvdrlbcefghsnuj-itw Eno [G] COG0148 Enolase 23 4 41 -omp-zyqvdrlbcefghsnuj-itw Pgi [G] COG0166 Glucose-6-phosphate isomerase 25 2 61 aompkzyqvdrlbcefghsnuj-itw GapA [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase 24 3 215 aompkzyqvd-lbcefghsnujxit- RhaT [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily 26 1 925 aompkzyqvdrlbcefghsnujxitw ProP [GEPR]COG0477 Permeases of the major facilitator superfamily 26 1 94 aompkzyqvdrlbcefghsnujxitw CpsG [G] COG1109 Phosphomannomutase 21 5 32 aompkzyqvdrlbcefg-snuj---- - [G] COG0063 Predicted sugar kinase 23 4 53 -ompkzy-vdrlbcefghsnuj-itw PykF [G] COG0469 Pyruvate kinase 21 5 50 aompkzyqv-rlb-efghs-ujx--w AraD [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases 23 4 57 --mpkzyqvdrlbcefghsnuj-itw TktA [G] COG0021 Transketolase 25 2 45 aompkzyqvdrlbcefghsnuj-itw TpiA [G] COG0149 Triosephosphate isomerase 19 8 32 ---pkzy-vdrlbcefghsnuj-i-- AroB [E] COG0337 3-dehydroquinate synthetase 20 6 36 aom-k-yqvdrlbcefghsnuj---- LeuC [E] COG0065 3-isopropylmalate dehydratase large subunit 18 8 30 ---pkzyqvd-lbcefghsnuj---- MetF [E] COG0685 5,10-methylenetetrahydrofolate reductase 23 4 39 aompkzyqvdrlbcefghsnuj-i-- AroA [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase 19 7 29 aom---yqvdrlbcefghsnuj---- HisG [E] COG0040 ATP phosphoribosyltransferase (histidine biosynthesis) 20 6 37 a-m-kzyqvdrlbcefghsnuj---- IlvH [E] COG0440 Acetolactate synthase, small subunit 20 6 38 a-m-kzyqvdrlbcefghsnuj---- ArgB [E] COG0548 Acetylglutamate kinase 20 6 30 a-m-kzyqvdrlbcefghsnuj---- ArgC [E] COG0002 Acetylglutamate semialdehyde dehydrogenase 22 5 108 a-mpkzyqvdrlb-efghsnujxi-- ArgE [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases 22 4 41 aompkzyqvdrlbcefghsnuj---- TrpD [E] COG0547 Anthranilate phosphoribosyltransferase 22 4 69 aompkzyqvdrlbcefghsnuj---- TrpE [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I 22 4 51 aompkzyqvdrlbcefghsnuj---- PabA [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II 20 6 31 aomp--yqvdrlbcefghsnuj---- ArgH [E] COG0165 Argininosuccinate lyase 20 6 30 aomp--yqvdrlbcefghsnuj---- ArgG [E] COG0137 Argininosuccinate synthase 24 3 44 aompkzyqvdrlbcefghsnujxi-- Asd [E] COG0136 Aspartate-semialdehyde dehydrogenase 24 3 56 aompkzyqvdrlbcefghsnujxi-- LysC [E] COG0527 Aspartokinases 20 6 66 aom---yqvdrlbcefghsnujx--- IlvE [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase 20 6 41 aomp--yqvdrlbcefghsnuj---- CarB [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) 20 6 36 aomp--yqvdrlbcefghsnuj---- CarA [EF] COG0505 Carbamoylphosphate synthase small subunit 20 6 43 aomp-zyqvdrlb-efghsnuj---- PheA [E] COG1605 Chorismate mutase 23 4 38 aompkzyqvdrlbcefghsnuj-i-- AroC [E] COG0082 Chorismate synthase 20 5 52 ao----yqvdrlbcefgh-nujxit- NifS [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes 20 6 63 -o-pkzyqvdrlbcefghsnuj---- CysK [E] COG0031 Cysteine synthase 20 6 49 a-m-kzyqvdrlbcefghsnuj---- IlvD [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase 17 10 44 ao-pkzy-vd--bcef-h-nuj-i-- GdhA [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase 19 7 30 aom---yqvdrlbcefghsnuj---- HisH [E] COG0118 Glutamine amidotransferase 23 3 64 aompkzyqvdrlbcefghsnujx--- GlnA [E] COG0174 Glutamine synthase 19 8 34 -o-pkzyqvdrlbcefg-sn-j-i-- GcvH [E] COG0509 Glycine cleavage system H protein (lipoate-binding) 26 1 53 aompkzyqvdrlbcefghsnujxitw GlyA [E] COG0112 Glycine hydroxymethyltransferase 21 6 120 ao-pkzyq--rlbcefghsnuj-it- DadA [E] COG0665 Glycine/D-amino acid oxidases (deaminating) 19 7 31 aom---yqvdrlbcefghsnuj---- HisD [E] COG0141 Histidinol dehydrogenase 22 4 54 aompkzyqvdrlbcefghsnuj---- HisC [E] COG0079 Histidinol-phosphate aminotransferase/Tyrosine aminotransferase 22 4 43 aompkzyqvdrlbcefghsnuj---- ThrA [E] COG0460 Homoserine dehydrogenase 19 7 30 -ompkzyqvdrlbce-ghs-uj---- ThrB [E] COG0083 Homoserine kinase 19 7 28 aom---yqvdrlbcefghsnuj---- HisB [E] COG0131 Imidazoleglycerol-phosphate dehydratase 19 7 30 aom---yqvdrlbcefghsnuj---- HisF [E] COG0107 Imidazoleglycerol-phosphate synthase 22 4 34 aompkzyqvdrlbcefghsnuj---- TrpC [E] COG0134 Indole-3-glycerol phosphate synthase 19 7 58 a-mpk-yqvdr-bcefghsnuj---- LeuA [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases 20 7 40 a-mpkzyqv-rlb-efghsnuj-i-- MetE [E] COG0620 Methionine synthase II (cobalamin-independent) 19 8 48 ---pkzyqvdrlbcefg-s-ujx-t- GltD [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases 22 5 79 aompkzyq-d--bcefghsnujxit- PutP [EHR] COG0591 Na+/proline, Na+/panthothenate symporters and related permeases 24 3 42 aompkzyqvdrlbcefghsnuj--tw ArgF [E] COG0078 Ornithine carbamoyltransferase 22 4 87 aompkzyqvdrlbcefghsnuj---- ArgD [E] COG0160 PLP-dependent aminotransferases 25 2 123 aompkzyqvdrlbcefghsnujxit- AvtA [E] COG0436 PLP-dependent aminotransferases 21 5 61 aompkzyqvdrlbcefghs-uj---- SerA [E] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases 19 7 28 aom---yqvdrlbcefghsnuj---- HisI [E] COG0139 Phosphoribosyl-AMP cyclohydrolase 18 6 27 -om---yqvdrlbcefghsnuj---- HisI [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase 22 5 33 aompkzyqvd-lbcefghsnuj-i-- TrpF [E] COG0135 Phosphoribosylanthranilate isomerase 19 7 28 aom---yqvdrlbcefghsnuj---- HisA [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 20 6 31 aomp--yqvdrlbcefghsnuj---- PheA [E] COG0077 Prephenate dehydratase 21 5 32 aomp-zyqvdrlbcefghsnuj---- TyrA [E] COG0287 Prephenate dehydrogenase 20 7 37 --mp-zyqvdrlbcefghsnuj--t- ProC [E] COG0345 Pyrroline-5-carboxylate reductase 21 5 54 -om-kzy-vdrlbcefghs-uj-itw CsdB [E] COG0520 Selenocysteine lyase 17 8 30 aompkzyqvd-lbc-fg---uj---- - [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase 23 4 45 aompkzyqvdrlbcefghsnuj-i-- AroE [E] COG0169 Shikimate 5-dehydrogenase 17 9 33 a-mpkzyqvdr-b-ef--snuj---- SpeE [E] COG0421 Spermidine synthase 21 5 103 a-mpkzyqvdrlbcefghsnuj---- IlvB [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] 22 4 48 aompkzyqvdrlbcefghsnuj---- ThrC [E] COG0498 Threonine synthase 23 4 35 aompkzyqvdrlbcefghsnuj-i-- TrpA [E] COG0159 Tryptophan synthase alpha chain 21 6 32 aom-k-yqvdrlbcefghsnuj-i-- TrpB [E] COG0133 Tryptophan synthase beta chain 26 1 84 aompkzyqvdrlbcefghsnujxitw PepP [E] COG0006 Xaa-Pro aminopeptidase 16 10 41 aom---yqvd-lbce-gh--uj--t- UshA [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases 19 5 29 ao-p--yqvdrlbcefghsnuj---- PurH [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 20 6 55 -om-kzy-vdrlbcefgh-nuj--tw Apt [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins 21 5 42 aompk-yqvdrlbcefghsnuj---- PurB [F] COG0015 Adenylosuccinate lyase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurA [F] COG0104 Adenylosuccinate synthase 21 5 34 aompkzyqvdrlbcefg-snuj---- PyrB [F] COG0540 Aspartate carbamoyltransferase, catalytic chain 26 1 44 aompkzyqvdrlbcefghsnujxitw PyrG [F] COG0504 CTP synthase (UTP-ammonia lyase) 18 8 53 aompkzyqvd--bcef-hs-uj---- SsnA [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases 25 2 74 aompkzyq-drlbcefghsnujxitw Hit [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases 19 7 44 aompkzyqvdrlbcef--s-uj---- PyrC [F] COG0044 Dihydroorotase 22 4 42 aompkzyqvdrlbcefghsnuj---- PyrD [F] COG0167 Dihydroorotate dehydrogenase 18 6 29 -o-p--yqvdrlbcefghsnuj---- PurN [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN 24 3 52 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0518 GMP synthase - Glutamine amidotransferase domain 24 3 37 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0519 GMP synthase - PP-ATPase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurF [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase 23 4 90 -ompkzyqvdrlbcefghsnuj-it- GuaB [F] COG0516 IMP dehydrogenase/GMP reductase 23 4 38 aompkzyq-dr-bcefghsnujxit- Ndk [F] COG0105 Nucleoside diphosphate kinase 23 4 40 aompkzyqvdrlbcefghsnuj-i-- PyrE [F] COG0461 Orotate phosphoribosyltransferase 22 4 36 aompkzyqvdrlbcefghsnuj---- PyrF [F] COG0284 Orotidine-5'-phosphate decarboxylase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurD [F] COG0151 Phosphoribosylamine-glycine ligase 21 5 33 aompk-yqvdrlbcefghsnuj---- PurM [F] COG0150 Phosphoribosylaminoimidazol (AIR) synthetase 17 7 26 -o-p--yqvdrlbcefghsn-j---- PurK [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 22 4 35 aompk-yqvdrlbcefghsnujx--- PurC [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase 21 5 32 aompk-yqvdrlbcefghsnuj---- PurE [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain 24 3 52 aompkzyqvdrlbcefghsnuj--tw PrsA [FE] COG0462 Phosphoribosylpyrophosphate synthetase 26 1 60 aompkzyqvdrlbcefghsnujxitw NrdA [F] COG0209 Ribonucleotide reductase alpha subunit 20 3 41 -o----yq-drlbcefghsnujxitw NrdF [F] COG0208 Ribonucleotide reductase beta subunit 26 1 48 aompkzyqvdrlbcefghsnujxitw Tmk [F] COG0125 Thymidylate kinase 21 5 32 -om-kzyqvdrlbcefgh-nuj--tw Upp [F] COG0035 Uracil phosphoribosyltransferase 13 6 26 -o----y-vd-lbce-gh-----itw Udk [F] COG0572 Uridine kinase 24 3 38 aompkzyqvdrlbcefghsnuj-it- - [F] COG0127 Xanthosine triphosphate pyrophosphatase 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibB [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 19 8 30 a-mpkzyq-d--bcefgh-nujxi-- UbiX [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase 19 8 34 a-mpkzyq-d--bcefgh-nujxi-- UbiD [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases 21 6 42 aompkzyq-d--bcefghsnujxi-- UbiA [H] COG0382 4-hydroxybenzoate polyprenyltransferase 22 3 42 -o-p--yqvdrlbcefghsnujxitw FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase 22 4 35 -om--zyq-drlbcefghsnujxitw - [H] COG0212 5-formyltetrahydrofolate cyclo-ligase 23 4 38 aom-k-yqvdrlbcefghsnujxit- BirA [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase 21 6 32 aomp-zyq-dr-bcefghsnujxi-- HemB [H] COG0113 Delta-aminolevulinic acid dehydratase 26 1 45 aompkzyqvdrlbcefghsnujxitw CoaE [H] COG0237 Dephospho-CoA kinase 23 4 44 aompkzyqvdrlbcefghsnuj-i-- FolP [H] COG0294 Dihydropteroate synthase 20 5 38 -o-p--yqvdrlbcefghsnujx-t- FolC [H] COG0285 Folylpolyglutamate synthase 25 2 78 aompkzyqvdrlbcefghsnujxit- IspA [H] COG0142 Geranylgeranyl pyrophosphate synthase 22 5 39 aompkzyqvdrlb-efghsnuj--t- ThiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 17 8 30 -o--kzyqvdr-bcefg-snuj---- PanB [H] COG0413 Ketopantoate hydroxymethyltransferase 23 4 41 aompkzyqvdrlbcefg-snuj--tw NadE [H] COG0171 NAD synthase 16 10 36 a---kzyqvdrlb-efgh--uj---- SIR2 [H] COG0846 NAD-dependent protein deacetylases, SIR2 family 19 7 32 aom-k-yqv-rlbcefghsnuj---- NadC [H] COG0157 Nicotinate-nucleotide pyrophosphorylase 23 4 37 ao-pkzyqvdrlbcefghsnuj--tw PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase 23 4 45 aompkzyqvdrlbcefghsnuj--t- Dfp [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase 21 6 33 aomp-zyq-dr-bcefghsnujxi-- HemC [H] COG0181 Porphobilinogen deaminase 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibD [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis 18 5 29 -o----yqvdrlbcefghsnuj-i-- RibC [H] COG0307 Riboflavin synthase alpha chain 21 6 34 aom--zyqvdrlbcefghsnuj-i-- RibH [H] COG0054 Riboflavin synthase beta-chain 19 8 36 aomp--yq-dr-bcefghsnu-xi-- HemD [H] COG1587 Uroporphyrinogen-III synthase 21 6 58 ao--k-yqvdrlbcefghsnujxi-- AccA [I] COG0825 Acetyl-CoA carboxylase alpha subunit 22 5 60 ao--k-yqvdrlbcefghsnujxit- AccB [I] COG0511 Biotin carboxyl carrier protein 21 6 70 aom---yq-drlbcefghsnujxit- AccC [I] COG0439 Biotin carboxylase 26 1 48 aompkzyqvdrlbcefghsnujxitw CdsA [I] COG0575 CDP-diglyceride synthetase 19 7 74 -om-k-yq-drlbcefghs-ujx-t- PgpB [I] COG0671 Membrane-associated phospholipid phosphatase 25 2 71 aompkzyqv-rlbcefghsnujxitw PgsA [I] COG0558 Phosphatidylglycerophosphate synthase 25 2 49 aompkzyqvdrlbcefghsnujxit- UppS [I] COG0020 Undecaprenyl pyrophosphate synthase 24 3 228 aompkzy-vdrlbcefghsnujx-tw CcmA [Q] COG1131 ABC-type multidrug transport system, ATPase component 21 4 204 -o--k-yqvdrlbcefghsnujxi-w MdlB [Q] COG1132 ABC-type multidrug/protein/lipid transport system, ATPase component 19 8 70 ao-pkzyqv-rlb-efg-snuj--t- PncA [Q] COG1335 Amidases related to nicotinamidase 23 4 481 ao-pkzyqvdrlbcefghsnujxi-- FabG [QR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 23 4 83 aom-kzyqvdrlbcefghsnuj--tw NorM [Q] COG0534 Na+-driven multidrug efflux pump 26 1 493 aompkzyqvdrlbcefghsnujxitw SmtA [QR] COG0500 SAM-dependent methyltransferases 23 3 65 aompkzyqvdrlbcefghsnuj---w RimI [R] COG0456 Acetyltransferases 18 8 60 -om-k-y-vdrlbcefgh-nuj-i-- WbbJ [R] COG0110 Acetyltransferases (the isoleucine patch superfamily) 25 2 212 aompkzyqvdrlbcefghsnujxit- - [R] COG0517 CBS domains 19 7 45 a-mpkzyqvdrlbcef-h-n-jx--- - [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family 26 1 81 aompkzyqvdrlbcefghsnujxitw ARC1 [R] COG0073 EMAP domain 18 6 39 aompkzy-vdrlbce--h---j-it- ElaC [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 18 9 31 aompk-yq--r-b-e-ghsnuj-i-w - [R] COG1881 Phospholipid-binding protein 26 1 49 aompkzyqvdrlbcefghsnujxitw - [R] COG0012 Predicted GTPase 19 5 33 aom-k-yqv--lb-efghsnujx--w - [R] COG0218 Predicted GTPases 22 5 64 aom---yqvdrlbcefghsnujxit- - [R] COG0042 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family 21 6 79 aompkzyqvdr-bcefg-snuj--t- - [R] COG0388 Predicted amidohydrolase 19 8 85 -ompk-yqvdrlb-efghsn-j--t- - [R] COG1011 Predicted hydrolases of the HAD superfamily 21 6 90 aompkzy-vdrlbce-gh-n-j-itw Cof [R] COG0561 Predicted hydrolases of the HAD superfamily 22 4 276 ao-p-zyq-drlbcefghsnujx-tw MhpC [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 24 3 48 aompkzyqv-rlbcefghsnujx-tw - [R] COG0061 Predicted kinase 21 6 53 aom-k-yq-drlbcefghsnuj--tw Gph [R] COG0546 Predicted phosphatases 21 6 77 aompkzyq-dr-bcefghs-uj--tw ThiJ [R] COG0693 Putative intracellular protease/amidase 19 6 30 aom--zyqvd---cefghsnuj-it- SurE [R] COG0496 Survival protein, predicted acid phosphatase 23 4 321 aompk-yqvd-lbcefghsnujxit- NrfG [R] COG0457 TPR-repeat-containing proteins 21 2 82 -o----yqvdrlbcefghsnujxitw - [R] COG1253 Uncharacterized CBS domain-containing proteins 21 5 99 aompkzyqvdrlbcefgh---j--tw HcaD [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases 22 5 44 aompkzyqvdrlbcefghs-uj--t- GlpG [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) 17 5 30 -o----yqvdrlbcefg-snuj---w CinA [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) 22 4 157 aompkzyqvdrlbcefghsnuj---- GloB [R] COG0491 Zn-dependent hydrolases, including glyoxylases 18 6 29 aompkzyqvdr--cefg-s-uj---- - [S] COG0062 Uncharacterized ACR LUCA1.0 Total number of events, gains and losses are 13782 8661 5121 Total inconsistency = 13782 572 COGs number of species/inconsistency (number of events)/number of genes 23 4 59 aompkz-qvdr-bcefghsnujxit- MiaB [J] COG0621 2-methylthioadenine synthetase 18 8 99 -o-pk-y-vdrlb-efgh-nujx--w RimL [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw AlaS [J] COG0013 Alanyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw ArgS [J] COG0018 Arginyl-tRNA synthetase 20 5 73 aom--zyqvdrlbc-f---nujxitw GatA [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases 20 5 34 aom--zyqvdrlbc-f---nujxitw GatB [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) 19 6 30 aom--z-qvdrlbc-f---nujxitw GatC [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit 20 2 35 ------yqvdrlbcefghsnujxitw AspS [J] COG0173 Aspartyl-tRNA synthetase 25 2 44 ao-pkzyqvdrlbcefghsnujxitw CysS [J] COG0215 Cysteinyl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw KsgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) 26 1 85 aompkzyqvdrlbcefghsnujxitw TufB [JE] COG0050 GTPases - translation elongation factors 26 1 75 aompkzyqvdrlbcefghsnujxitw GlnS [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases 26 1 58 aompkzyqvdrlbcefghsnujxitw HisS [J] COG0124 Histidyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw IleS [J] COG0060 Isoleucyl-tRNA synthetase 26 1 48 aompkzyqvdrlbcefghsnujxitw LeuS [J] COG0495 Leucyl-tRNA synthetase 17 4 37 ------yqvdrlbcefghsnu--i-w LysU [J] COG1190 Lysyl-tRNA synthetase class II 26 1 55 aompkzyqvdrlbcefghsnujxitw Map [J] COG0024 Methionine aminopeptidase 20 2 40 ------yqvdrlbcefghsnujxitw Fmt [J] COG0223 Methionyl-tRNA formyltransferase 26 1 48 aompkzyqvdrlbcefghsnujxitw MetG [J] COG0143 Methionyl-tRNA synthetase 20 2 37 ------yqvdrlbcefghsnujxitw Pth [J] COG0193 Peptidyl-tRNA hydrolase 26 1 46 aompkzyqvdrlbcefghsnujxitw PheS [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit 26 1 46 aompkzyqvdrlbcefghsnujxitw PheT [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit 10 3 15 aompkzyqv-r--------------- GCD14 [J] COG2519 Predicted SAM-dependent methyltransferase involved in tRNA-Met maturation 25 2 58 aompk-yqvdrlbcefghsnujxitw HemK [J] COG2890 Predicted rRNA or tRNA methylase 20 2 39 ------yqvdrlbcefghsnujxitw TrmU [J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain 26 1 47 aompkzyqvdrlbcefghsnujxitw ProS [J] COG0442 Prolyl-tRNA synthetase 20 2 36 ------yqvdrlbcefghsnujxitw PrfA [J] COG0216 Protein chain release factor A 19 3 41 ------yqvdrlbcefghsnujxit- PrfB [J] COG1186 Protein chain release factor B 26 1 45 aompkzyqvdrlbcefghsnujxitw TruB [J] COG0130 Pseudouridine synthase 25 2 46 aompk-yqvdrlbcefghsnujxitw TruA [J] COG0101 Pseudouridylate synthase (tRNA psi55) 20 2 101 ------yqvdrlbcefghsnujxitw RluA [J] COG0564 Pseudouridylate synthases, 23S RNA-specific 25 2 54 aompkzyqvdrlbcefghsn-jxitw SUA5 [J] COG0009 Putative translation factor (SUA5) 19 6 76 -o--kzyqvdrlbcefghsnuj---- TdcF [J] COG0251 Putative translation initiation inhibitor 23 4 38 aompkz-qvd-lbcefghsnujxit- Tgt [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase 26 1 47 aompkzyqvdrlbcefghsnujxitw RplA [J] COG0081 Ribosomal protein L1 26 1 49 aompkzyqvdrlbcefghsnujxitw RplJ [J] COG0244 Ribosomal protein L10 26 1 49 aompkzyqvdrlbcefghsnujxitw RplK [J] COG0080 Ribosomal protein L11 26 1 48 aompkzyqvdrlbcefghsnujxitw RplM [J] COG0102 Ribosomal protein L13 26 1 47 aompkzyqvdrlbcefghsnujxitw RplN [J] COG0093 Ribosomal protein L14 26 1 45 aompkzyqvdrlbcefghsnujxitw RplO [J] COG0200 Ribosomal protein L15 26 1 48 aompkzyqvdrlbcefghsnujxitw RplP [J] COG0197 Ribosomal protein L16/L10E 20 2 35 ------yqvdrlbcefghsnujxitw RplQ [J] COG0203 Ribosomal protein L17 26 1 44 aompkzyqvdrlbcefghsnujxitw RplR [J] COG0256 Ribosomal protein L18 20 2 35 ------yqvdrlbcefghsnujxitw RplS [J] COG0335 Ribosomal protein L19 26 1 45 aompkzyqvdrlbcefghsnujxitw RplB [J] COG0090 Ribosomal protein L2 26 1 48 aompkzyqvdrlbcefghsnujxitw RplV [J] COG0091 Ribosomal protein L22 26 1 43 aompkzyqvdrlbcefghsnujxitw RplW [J] COG0089 Ribosomal protein L23 26 1 44 aompkzyqvdrlbcefghsnujxitw RplX [J] COG0198 Ribosomal protein L24 20 2 35 ------yqvdrlbcefghsnujxitw RpmA [J] COG0211 Ribosomal protein L27 20 2 35 ------yqvdrlbcefghsnujxitw RpmB [J] COG0227 Ribosomal protein L28 26 1 44 aompkzyqvdrlbcefghsnujxitw RpmC [J] COG0255 Ribosomal protein L29 26 1 46 aompkzyqvdrlbcefghsnujxitw RplC [J] COG0087 Ribosomal protein L3 22 5 39 aompkzyqvdrlb-efghsn-jx-t- RpmD [J] COG1841 Ribosomal protein L30/L7E 19 3 33 ------yqvd-lbcefghsnujxitw RpmF [J] COG0333 Ribosomal protein L32 20 2 40 ------yqvdrlbcefghsnujxitw RpmG [J] COG0267 Ribosomal protein L33 20 2 34 ------yqvdrlbcefghsnujxitw RpmH [J] COG0230 Ribosomal protein L34 20 2 34 ------yqvdrlbcefghsnujxitw RpmI [J] COG0291 Ribosomal protein L35 20 2 39 ------yqvdrlbcefghsnujxitw RpmJ [J] COG0257 Ribosomal protein L36 26 1 47 aompkzyqvdrlbcefghsnujxitw RplD [J] COG0088 Ribosomal protein L4 26 1 47 aompkzyqvdrlbcefghsnujxitw RplE [J] COG0094 Ribosomal protein L5 26 1 47 aompkzyqvdrlbcefghsnujxitw RplF [J] COG0097 Ribosomal protein L6 20 2 36 ------yqvdrlbcefghsnujxitw RplL [J] COG0222 Ribosomal protein L7/L12 19 3 35 ------yqvdrlbcefghsnujxit- RpsA [J] COG0539 Ribosomal protein S1 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsJ [J] COG0051 Ribosomal protein S10 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsK [J] COG0100 Ribosomal protein S11 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsL [J] COG0048 Ribosomal protein S12 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsM [J] COG0099 Ribosomal protein S13 26 1 50 aompkzyqvdrlbcefghsnujxitw RpsN [J] COG0199 Ribosomal protein S14 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsO [J] COG0184 Ribosomal protein S15P/S13E 20 2 35 ------yqvdrlbcefghsnujxitw RpsP [J] COG0228 Ribosomal protein S16 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsQ [J] COG0186 Ribosomal protein S17 20 2 36 ------yqvdrlbcefghsnujxitw RpsR [J] COG0238 Ribosomal protein S18 26 1 45 aompkzyqvdrlbcefghsnujxitw RpsS [J] COG0185 Ribosomal protein S19 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsB [J] COG0052 Ribosomal protein S2 26 1 44 aompkzyqvdrlbcefghsnujxitw RpsC [J] COG0092 Ribosomal protein S3 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsD [J] COG0522 Ribosomal protein S4 and related proteins 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsE [J] COG0098 Ribosomal protein S5 20 2 35 ------yqvdrlbcefghsnujxitw RpsF [J] COG0360 Ribosomal protein S6 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsG [J] COG0049 Ribosomal protein S7 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsH [J] COG0096 Ribosomal protein S8 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsI [J] COG0103 Ribosomal protein S9 20 2 36 ------yqvdrlbcefghsnujxitw Frr [J] COG0233 Ribosome recycling factor 17 7 45 ----k-yqv-rlbcefghsnuj-i-- TrmA [J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase 26 1 46 aompkzyqvdrlbcefghsnujxitw SerS [J] COG0172 Seryl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw ThrS [J] COG0441 Threonyl-tRNA synthetase 26 1 80 aompkzyqvdrlbcefghsnujxitw FusA [J] COG0480 Translation elongation and release factors (GTPases) 26 1 52 aompkzyqvdrlbcefghsnujxitw Efp [J] COG0231 Translation elongation factor P/translation initiation factor eIF-5A 26 1 49 aompkzyqvdrlbcefghsnujxitw InfB [J] COG0532 Translation initiation factor 2 (GTPase) 26 1 46 aompkzyqvdrlbcefghsnujxitw InfA [J] COG0361 Translation initiation factor IF-1 13 8 17 a-mpkzyqv---bc-f--s--j---- GCN3 [J] COG0182 Translation initiation factor eIF-2B alpha subunit 26 1 49 aompkzyqvdrlbcefghsnujxitw TrpS [J] COG0180 Tryptophanyl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw TyrS [J] COG0162 Tyrosyl-tRNA synthetase 26 1 45 aompkzyqvdrlbcefghsnujxitw ValS [J] COG0525 Valyl-tRNA synthetase 21 3 68 a-----yqvdrlbcefghsnujxitw SpoU [J] COG0566 rRNA methylases 21 6 54 aom-kzy-vdrlbcefghsnuj-i-- Sun [J] COG0144 tRNA and rRNA cytosine-C5-methylases 19 3 32 ------yqvdrlbcefghsnujxit- MiaA [J] COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase 19 3 50 ------yqvdrlbcefghsnujxit- PcnB [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase 26 1 46 aompkzyqvdrlbcefghsnujxitw RpoA [K] COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw RpoB [K] COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) 26 1 63 aompkzyqvdrlbcefghsnujxitw RpoC [K] COG0086 DNA-directed RNA polymerase beta' subunit/160 kD subunit (split gene in archaea and Syn) 24 3 38 aompkzyqvdrlbcefghsnujx-t- RpoZ [K] COG1758 DNA-directed RNA polymerase subunit K/omega 19 4 48 -o----yqvd-lbcefghsnuj-itw VacB [K] COG0557 Exoribonucleases 24 3 309 aompkzyqvdrlbcefghsnuj-i-w WecD [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases 16 9 35 aompkz--vdrlb-e---s--j-it- TroR [K] COG1321 Mn-dependent transcriptional regulator 14 6 22 aompkzy-vd-lbc------u---t- - [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP 21 5 148 aompkz-qvdrlbcefghsnuj---- ArsR [K] COG0640 Predicted transcriptional regulators 20 7 57 aom-kz-q-drlb-efg-snujxit- Spo0J [K] COG1475 Predicted transcriptional regulators 19 6 74 ao-pkzy-vdrlbcefghs----i-w HepA [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family 26 1 48 aompkzyqvdrlbcefghsnujxitw NusG [K] COG0250 Transcription antiterminator 25 2 47 aompkz-qvdrlbcefghsnujxitw NusA [K] COG0195 Transcription terminator 20 6 307 aom-k--qvdrlbcefghsnuj---w AcrR [K] COG1309 Transcriptional regulator 16 8 73 ao-p-z-qvdrlbce-gh---j--t- NagC [K] COG1940 Transcriptional regulators 20 2 43 ------yqvdrlbcefghsnujxitw Rnc [K] COG0571 dsRNA-specific ribonuclease 26 1 61 aompkzyqvdrlbcefghsnujxitw Exo [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 16 8 21 aompkz-qvd-lbcefg-------t- SbcC [L] COG0419 ATPase involved in DNA repair 25 2 75 aompkzyqvdrlbcefghsnu-xitw HolB [L] COG0470 ATPase involved in DNA replication 23 2 63 ao-p--yqvdrlbcefghsnujxitw GyrA [L] COG0188 DNA gyrase (topoisomerase II) A subunit 23 2 62 ao-p--yqvdrlbcefghsnujxitw GyrB [L] COG0187 DNA gyrase (topoisomerase II) B subunit 18 5 34 -o----yqvd-lbcefghsn-jxit- MutL [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) 19 3 31 ------yqvdrlbcefghsnujxit- PolA [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains 26 1 47 aompkzyqvdrlbcefghsnujxitw DnaN [L] COG0592 DNA polymerase III beta subunit 21 4 63 a--p--yqvdrlbcefghsnujxit- DnaQ [L] COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonucleases 25 2 46 aompkz-qvdrlbcefghsnujxitw DnaG [L] COG0358 DNA primase (bacterial type) 18 6 27 aompkzyqvdrlbcefg-------t- SbcD [L] COG0420 DNA repair exonuclease 14 9 27 -ompkzyqv-r-b-e-g------i-w Nfo [L] COG0648 Endonuclease IV 25 2 219 aompkz-qvdrlbcefghsnujxitw XerC [L] COG0582 Integrase 22 5 47 aompkzyqv-rlb-efghsnuj-it- Ada [L] COG0350 Methylated DNA-protein cysteine methyltransferase 23 3 58 --m-kzyqvdrlbcefghsnujxitw TatD [L] COG0084 Mg-dependent DNase 12 11 24 -om-k-yq----b--f-h-nuj---w - [L] COG1525 Micrococcal nuclease (thermonuclease) homologs 19 6 42 -o-p--yqvd-lbcefghsn-jxit- MutS [L] COG0249 MutS-like ATPases involved in mismatch repair, family 2 24 3 198 aomp-zyqvdrlbcefghsnujxit- MutT [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes 25 2 47 aompkzyqvdrlbcefghsnujxit- Nth [L] COG0177 Predicted EndoIII-related endonuclease 13 9 88 -ompk--qvdr--ce---s-u---t- - [L] COG0675 Predicted transposases 26 1 62 aompkzyqvdrlbcefghsnujxitw RecA [L] COG0468 RecA/RadA recombinase 16 6 31 -o----y--dr-bcefghsnujx-t- RnhA [L] COG0328 Ribonuclease HI 25 2 39 aompkzyqvdrlbcefghsnujxit- RnhB [L] COG0164 Ribonuclease HII 20 2 50 ------yqvdrlbcefghsnujxitw Ssb [L] COG0629 Single-stranded DNA-binding protein 22 5 48 aompk--qvd-lbcefghsnujxit- RecJ [L] COG0608 Single-stranded DNA-specific exonuclease 23 4 78 -omp--yqvdrlbcefghsnujxitw UvrD [L] COG0210 Superfamily I DNA and RNA helicases 15 9 42 aompk-yqv-r--cef--s-u----w - [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits 21 6 165 a-mp--yq-drlbcefghsnujx-tw SrmB [LKJ] COG0513 Superfamily II DNA and RNA helicases 26 1 59 aompkzyqvdrlbcefghsnujxitw TopA [L] COG0550 Topoisomerase IA 18 9 34 ao-pkz-qvdrl-c--gh-nujx-t- - [L] COG1573 Uracil-DNA glycosylase 18 6 40 aompk---v--lb-efghsnu--itw TopA [L] COG0551 Zn-finger domain associated with topoisomerase type I 20 7 92 -ompk--q-dr-bcefg-snujxitw Soj [D] COG1192 ATPases involved in chromosome partitioning 22 4 55 aompkzyqvdr-bcefghsnujx--- Mrp [D] COG0489 ATPases involved in chromosome partitioning 23 4 57 aompk--qvdrlbcefghsnujx-tw FtsZ [D] COG0206 Cell division GTPase 19 6 41 aompk-yqvdrlbc-f--sn-j--tw Smc [D] COG1196 Chromosome segregation ATPases 17 7 46 a-mp--yqv---b-efghs-ujxit- MreB [D] COG1077 HSP70 class molecular chaperones involved in cell morphogenesis 18 7 32 -om-k-yqvdr-bcefghsnuj---- CrcB [D] COG0239 Integral membrane protein possibly involved in chromosome condensation 19 3 34 ------yqvd-lbcefghsnujxitw GidA [D] COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division 18 6 36 ----k-yqvdr-bcefghsnujxi-- Maf [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation 26 1 79 aompkzyqvdrlbcefghsnujxitw MesJ [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control 17 4 34 ------yqvd--b-efghsnujxitw Lon [O] COG0466 ATP-dependent Lon protease, bacterial type 20 2 50 ------yqvdrlbcefghsnujxitw HflB [O] COG0465 ATP-dependent Zn proteases 19 3 32 ------yqvdrlbcefghsnujxit- ClpX [O] COG1219 ATP-dependent protease Clp, ATPase subunit 21 3 81 --m---yqvdrlbcefghsnujxitw ClpA [O] COG0542 ATPases with chaperone activity, ATP-binding subunit 26 1 80 aompkzyqvdrlbcefghsnujxitw GroL [O] COG0459 Chaperonin GroEL (HSP60 family) 20 2 38 ------yqvdrlbcefghsnujxitw GroS [O] COG0234 Co-chaperonin GroES (HSP10) 18 6 33 -om---y--drlbcefghsnuj--tw - [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase 20 7 57 aom-k-y-vdrlbcefghsn-jx-t- GrxC [O] COG0695 Glutaredoxin and related proteins 24 3 82 aompkzyqvdrlbcefghsnujx-t- HflC [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs 26 1 47 aompkzyqvdrlbcefghsnujxitw QRI7 [O] COG0533 Metal-dependent proteases with possible chaperone activity 23 4 93 -omp--yqvdrlbcefghsnujxitw DnaK [O] COG0443 Molecular chaperone 19 7 52 aompkzyqvdr-bcefg-s--jx--- IbpA [O] COG0071 Molecular chaperone (small heat shock protein) 23 4 40 -omp--yqvdrlbcefghsnujxitw GrpE [O] COG0576 Molecular chaperone GrpE (heat shock protein) 23 4 115 -omp--yqvdrlbcefghsnujxitw DnaJ [O] COG0484 Molecular chaperones (contain C-terminal Zn finger domain) 17 5 68 ------yqvd-lbcefghsnujx-t- SurA [O] COG0760 Parvulin-like peptidyl-prolyl isomerase 18 6 38 -om---y--drlbcefghsnuj--tw MsrA [O] COG0225 Peptide methionine sulfoxide reductase 17 7 58 -om---y--drlbcefghsnuj--t- PpiB [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family 24 3 54 aompkzyqvdrlbcefghs-ujxit- AhpC [O] COG0450 Peroxiredoxin 18 7 40 -o-p-zyqvdr-bcefghsnuj---- Bcp [O] COG1225 Peroxiredoxin 20 6 72 aompkzyqv-r-b-efghs-ujx-t- HslV [O] COG0638 Proteasome protease subunit 17 7 68 ao---zyq-drlbc-fg-snuj---w AprE [O] COG1404 Subtilisin-like serine proteases 26 1 239 aompkzyqvdrlbcefghsnujxitw TrxA [OC] COG0526 Thiol-disulfide isomerase and thioredoxins 26 1 76 aompkzyqvdrlbcefghsnujxitw TrxB [O] COG0492 Thioredoxin reductase 21 4 81 -om---yqvdrlbcefghsnujxit- DegQ [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain 21 5 76 aompkzyq-drlbcefghsnuj---- HtpX [O] COG0501 Zn-dependent protease with chaperone function 23 4 43 -ompkzyqvdrlbcefghsnuj-it- GlmS [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains 25 2 238 aompkzyqvdrlbcefghsnujx-tw WcaA [M] COG0463 Glycosyltransferases involved in cell wall biogenesis 22 5 162 aompk-yqvdrlbcefghsnuj--t- WcaG [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 19 8 56 aompkzyq-dr-bc-f-hsnuj--t- GCD1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylases involved in lipopolysaccharide biosynthesis/translation initiation factor eIF2B subunits 24 3 260 aompkzyqvdrlbcefghsnujx-t- RfaG [M] COG0438 Predicted glycosyltransferases 24 3 52 aompkz-qvdrlbcefghsnujxit- - [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1 16 4 40 ------yqvd---cefghsnujxit- - [M] COG0729 Predicted outer membrane protein 17 7 29 a-m-kzyq----b-efghsnujxi-- GutQ [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation 22 5 80 aompkz-qvdrlbcefg-snujx-t- MscS [M] COG0668 Small-conductance mechanosensitive channel 21 4 56 --m-k-yqvdrlbcefghsnujxit- Rfe [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase 20 2 35 ------yqvdrlbcefghsnujxitw LepA [N] COG0481 Membrane GTPase LepA 23 4 56 aompkz-qvdr-bcefghsnujxit- SppA [NO] COG0616 Periplasmic serine proteases (ClpP class) 26 1 46 aompkzyqvdrlbcefghsnujxitw SecY [N] COG0201 Preprotein translocase subunit SecY 20 2 40 ------yqvdrlbcefghsnujxitw YidC [N] COG0706 Preprotein translocase subunit YidC 25 2 68 aompkzyqvdrlbcefghsnujxit- LepB [N] COG0681 Signal peptidase I 19 7 33 aom-kz-qvd-lbcefghsnuj---- PppA [N] COG1989 Signal peptidase, cleaves prepilin-like proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw Ffh [N] COG0541 Signal recognition particle GTPase 26 1 46 aompkzyqvdrlbcefghsnujxitw FtsY [N] COG0552 Signal recognition particle GTPase 22 5 46 aom-kz-qvdrlbcefgh-nujxit- ZnuA [P] COG0803 ABC-type Mn/Zn transport system, periplasmic Mn/Zn-binding (lipo)protein (surface adhesin A) 21 6 41 aom-kz-qvd-lbcefgh-nujxit- ZnuC [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component 22 5 49 aom-kz-qvdrlbcefgh-nujxit- ZnuB [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components 21 6 38 aom-kz-qvdrlbcefghs-uj--tw PstB [P] COG1117 ABC-type phosphate transport system, ATPase component 21 6 46 aom-kz-qvdrlbcefghs-uj--tw PstS [P] COG0226 ABC-type phosphate transport system, periplasmic component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstA [P] COG0581 ABC-type phosphate transport system, permease component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstC [P] COG0573 ABC-type phosphate transport system, permease component 15 11 23 a---kzyq-dr-bcefg-s-uj---- CysC [P] COG0529 Adenylylsulfate kinase and related kinases 17 9 38 a-mp--yqvdrlbcef--sn-j---w AmtB [P] COG0004 Ammonia permeases 14 7 25 aompk-yqv---bce-gh------t- ECM27 [P] COG0530 Ca2+/Na+ antiporter 24 3 89 aompkzyqvdrlbcefgh-nuj-itw ZntA [P] COG2217 Cation transport ATPases 15 8 28 ----k-yqvdrlb-ef-hsnuj---- CzcD [P] COG1230 Co/Zn/Cd efflux system component 16 8 30 ao-p-zyqvd-lbc-f-h-nu----w CopZ [P] COG2608 Copper chaperone 17 8 50 -om-k-yq-d-lbcefghsnu--i-- CitT [P] COG0471 Di- and tricarboxylate transporters 20 6 46 aom-kz-qvdrlbcefgh-nu---tw TrkA [P] COG0569 K+ transport systems, NAD-binding component 22 5 60 a-mpkzyq-drlbcefghsnujx-t- KefB [P] COG0475 Kef-type K+ transport systems, membrane components 24 2 79 aompkzyqvdrlbcefghsnujx--w Kch [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component 18 8 47 a-m-k-yqvdrlbcefghs-uj---- CorA [P] COG0598 Mg2+ and Co2+ transporters 20 7 50 aompkz-qvdrlbcefg-s--j--tw PhoU [P] COG0704 Phosphate uptake regulator 18 9 50 aompk-y-vdr-b-efgh-nuj-i-- PitA [P] COG0306 Phosphate/sulphate permeases 21 6 36 aom-kzyqvdrlbcefgh--ujx-t- MMT1 [P] COG0053 Predicted Co/Zn/Cd cation transporters 14 9 23 -om-kzyqvdr---ef---nu---t- - [P] COG0428 Predicted divalent heavy-metal cations transporter 21 6 95 aomp--yq-drlbcefghsnujx-t- PspE [P] COG0607 Rhodanese-related sulfurtransferases 22 5 49 -omp-zyq-drlbcefghsnujxit- SodA [P] COG0605 Superoxide dismutase 20 6 37 aom-kzyqvd-lbcefgh-nu---tw TrkG [P] COG0168 Trk-type K+ transport systems, membrane components 20 7 334 aom-k-y-vdrlbcefghs-ujx-t- CheY [T] COG0784 CheY-like receiver domains 20 6 79 aompkzy-vd-lbcefghsnuj---- ApaH [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases 14 10 64 aom---yqvdr-bcefg----j---- FhlA [T] COG2203 GAF domain 14 8 43 ---p--yq-drlbc-f--s-uj-i-w PTC1 [T] COG0631 Protein serine/threonine phosphatases 18 8 42 aom---yq-drlbcefghsnuj---- Wzb [T] COG0394 Protein-tyrosine-phosphatase 11 4 46 aompkzyqv----c-------j---- RAD55 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction 22 5 549 aom---yqvdrlbcefghsnujxit- BaeS [T] COG0642 Sensory transduction histidine kinases 18 8 297 -o-p-zyq-drlbcefghs--j-i-w SPS1 [T] COG0515 Serine/threonine protein kinases 20 6 116 aompkzyq-drlbcefgh-n-jx--- UspA [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins 18 4 90 ------yqvdrlbcefghsnuj-it- Crp [T] COG0664 cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 16 9 30 -o-p-zyq-drlb-efg-sn-jx--- AcnA [C] COG1048 Aconitase A 16 5 35 aompkzyqv--lb-efgh---j---- EutG [C] COG1454 Alcohol dehydrogenase IV 22 4 51 aomp-zyqvdrlbcefghsnujx--- GltA [C] COG0372 Citrate synthase 16 8 30 -o-p-zyq-dr-bc-fg-snujx--- QcrB [C] COG1290 Cytochrome b subunit of the bc complex 16 9 34 ao-p---q--rlbcefgh--ujxi-- CydA [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 16 7 56 aompkzyqv-r--cef--sn-j---- FixC [C] COG0644 Dehydrogenases (flavoproteins) 19 6 77 -o-p-zy--drlbcefghsn-jxi-w AceF [C] COG0508 Dihydrolipoamide acyltransferases 23 4 97 aomp-zyqvdrlbcefghsn-jxi-w Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes 17 4 29 ------yqv-rlbcefghsnujx--w AtpB [C] COG0356 F0F1-type ATP synthase a subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpA [C] COG0056 F0F1-type ATP synthase alpha subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpD [C] COG0055 F0F1-type ATP synthase beta subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw AtpE [C] COG0636 F0F1-type ATP synthase c subunit/Archaeal/vacuolar-type H+-ATPase subunit K 17 4 31 ------yqv-rlbcefghsnujx--w AtpH [C] COG0712 F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) 17 4 30 ------yqv-rlbcefghsnujx--w AtpC [C] COG0355 F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) 17 4 32 ------yqv-rlbcefghsnujx--w AtpG [C] COG0224 F0F1-type ATP synthase gamma subunit 18 7 100 ao-p-zyq-dr-bcefghsnuj---- GlcD [C] COG0277 FAD/FMN-containing dehydrogenases 15 8 49 ao----yq-dr--cefgh-n-jxi-- Fdx [C] COG0633 Ferredoxin 19 5 36 aompkzyqvdr--cef--snujx--- NuoI [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) 17 7 31 -o---zy--dr-bcefghsnujxi-- FumC [C] COG0114 Fumarase 22 4 37 a-m---yqvdrlbcefghsnujxitw GpsA [C] COG0240 Glycerol 3-phosphate dehydrogenase 21 6 33 ao-pkzyqvdrlbcefghs--j--tw GlpK [C] COG0554 Glycerol kinase 17 9 50 -o-pkzy-vdrlb-efgh---j--tw UgpQ [C] COG0584 Glycerophosphoryl diester phosphodiesterase 22 5 41 -ompkzyq-dr-bcefghsnujxi-w Ppa [C] COG0221 Inorganic pyrophosphatase 17 8 28 ao-p-zyqvdrlbcef-h--uj---- Icd [C] COG0538 Isocitrate dehydrogenases 20 6 44 aompkzy--drlbcefgh-n-jx-t- LldD [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases 16 11 57 ---pkzyq---lbcefgh-nuj--t- LdhA [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases 23 4 45 aomp-zyqvdrlbce-ghs-ujxitw Mdh [C] COG0039 Malate/lactate dehydrogenases 21 5 42 ao-pkzy-vdrlbcefghsnujx--- SfcA [C] COG0281 Malic enzyme 19 7 202 -omp-zyq-drlbcefgh-nuj---w PutA [C] COG1012 NAD-dependent aldehyde dehydrogenases 13 6 21 ------yqvdr--cef--snujx--- NuoG [C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) 18 6 26 ao-pkzyqvdr--cef--snujx--- NuoB [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoC [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoD [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 16 10 39 -o--kz-q-dr-b-efg-s-ujxit- GltP [C] COG1301 Na+/H+-dicarboxylate symporters 19 6 37 ao----yqv-rlb-efgh-nujxitw IscU [C] COG0822 NifU homologs involved in Fe-S cluster formation 21 5 89 aompkz-qvdrlbcefghsnuj---- NfnB [C] COG0778 Nitroreductase 18 8 94 -o-p-zyqvdrlbcefg-s-uj--t- Tas [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) 18 8 63 aompkzyqv-rlbce-g---uj--t- PorA [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit 18 8 60 aompkzyqv-rlbce-g---uj--t- PorB [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit 17 9 55 aompkz-qv-rlbce-g---uj--t- PorG [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit 16 8 35 -o-p-zyq-dr-bc-fg-snujx--- QcrA [C] COG0723 Rieske Fe-S protein 21 6 41 aomp-zyq-dr-bcefghsnujxi-- FrdB [C] COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein 17 8 28 ao-p-zy--dr-b-efg-snujxi-- SdhC [C] COG2009 Succinate dehydrogenase/fumarate reductase cytochrome b subunit 23 4 54 aomp-zyqvdrlbcefghsnujxi-- SdhA [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunits 21 6 38 aomp-zyq-dr-bcefghsnujxi-- SucD [C] COG0074 Succinyl-CoA synthetase alpha subunit 21 6 34 aomp-zyq-dr-bcefghsnujxi-- SucC [C] COG0045 Succinyl-CoA synthetase beta subunit 25 2 43 aompkzyqvdrlbcefghsnuj-itw Pgk [G] COG0126 3-phosphoglycerate kinase 16 6 35 ------yqvdrlbce-ghs--j-itw PfkA [G] COG0205 6-phosphofructokinase 16 6 42 ------y-v-rlbcefghsnuj-it- NagB [G] COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase 23 4 175 aompkz-qvdrlbcefghsnuj--tw MalK [G] COG1130 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component 23 4 48 aom-kzyqvdrlbcefghsnujx-t- SuhB [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family 16 6 41 ------y-vdrlbcefghsn-jx-t- BglX [G] COG1472 Beta-glucosidase-related glycosidases 25 2 51 aompkzyqvdrlbcefghsnuj-itw Eno [G] COG0148 Enolase 17 5 42 ------yqvdrlbcefgh-nuj--tw Fba [G] COG0191 Fructose/tagatose bisphosphate aldolase 18 4 31 ------yqvdrlbcefghsnuj-it- Zwf [G] COG0364 Glucose-6-phosphate 1-dehydrogenase 23 4 41 -omp-zyqvdrlbcefghsnuj-itw Pgi [G] COG0166 Glucose-6-phosphate isomerase 25 2 61 aompkzyqvdrlbcefghsnuj-itw GapA [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase 21 5 40 --mp--yqvdrlbcefghsnuj-itw Rpe [G] COG0036 Pentose-5-phosphate-3-epimerase 24 3 215 aompkzyqvd-lbcefghsnujxit- RhaT [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily 26 1 925 aompkzyqvdrlbcefghsnujxitw ProP [GEPR]COG0477 Permeases of the major facilitator superfamily 21 6 43 aompkz-qvdr-bcefg-snujx-t- PpsA [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase 26 1 94 aompkzyqvdrlbcefghsnujxitw CpsG [G] COG1109 Phosphomannomutase 21 5 32 aompkzyqvdrlbcefg-snuj---- - [G] COG0063 Predicted sugar kinase 15 10 30 ao--kzyqv-rlb-ef----ujx--- NagD [G] COG0647 Predicted sugar phosphatases of the HAD superfamily 23 4 53 -ompkzy-vdrlbcefghsnuj-itw PykF [G] COG0469 Pyruvate kinase 19 7 31 aompkzy--d-l-cefghsn-j-it- RpiA [G] COG0120 Ribose 5-phosphate isomerase 21 5 50 aompkzyqv-rlb-efghs-ujx--w AraD [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases 18 8 40 --mp--yqvdrlbcefgh-nuj-i-- MipB [G] COG0176 Transaldolase 23 4 57 --mpkzyqvdrlbcefghsnuj-itw TktA [G] COG0021 Transketolase 25 2 45 aompkzyqvdrlbcefghsnuj-itw TpiA [G] COG0149 Triosephosphate isomerase 19 8 32 ---pkzy-vdrlbcefghsnuj-i-- AroB [E] COG0337 3-dehydroquinate synthetase 20 6 36 aom-k-yqvdrlbcefghsnuj---- LeuC [E] COG0065 3-isopropylmalate dehydratase large subunit 19 7 35 a-m-k-yqvdrlbcefghsnuj---- LeuD [E] COG0066 3-isopropylmalate dehydratase small subunit 18 8 30 ---pkzyqvd-lbcefghsnuj---- MetF [E] COG0685 5,10-methylenetetrahydrofolate reductase 23 4 39 aompkzyqvdrlbcefghsnuj-i-- AroA [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase 19 7 91 ao-pkz-qvd-lb-efgh--uj-itw OppF [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 19 7 87 ao-pkz-qvd-lb-efgh--uj-itw DppD [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 21 6 173 ao-pkz-qvdrlbcefgh--uj-itw OppA [EP] COG0747 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components 21 6 125 ao-pkz-qvdrlbcefgh--uj-itw DppB [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 21 6 124 ao-pkz-qvdrlbcefgh--uj-itw DppC [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 15 10 51 ao---z--vd-l--efgh-nuj--tw PotB [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I 15 10 51 ao---z--vd-l--efgh-nuj--tw PotC [E] COG1177 ABC-type spermidine/putrescine transport system, permease component II 19 7 29 aom---yqvdrlbcefghsnuj---- HisG [E] COG0040 ATP phosphoribosyltransferase (histidine biosynthesis) 20 6 37 a-m-kzyqvdrlbcefghsnuj---- IlvH [E] COG0440 Acetolactate synthase, small subunit 20 6 38 a-m-kzyqvdrlbcefghsnuj---- ArgB [E] COG0548 Acetylglutamate kinase 20 6 30 a-m-kzyqvdrlbcefghsnuj---- ArgC [E] COG0002 Acetylglutamate semialdehyde dehydrogenase 22 5 108 a-mpkzyqvdrlb-efghsnujxi-- ArgE [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases 19 7 170 aomp-zy---rlbcefghs--jxi-w PotE [E] COG0531 Amino acid transporters 22 4 41 aompkzyqvdrlbcefghsnuj---- TrpD [E] COG0547 Anthranilate phosphoribosyltransferase 22 4 69 aompkzyqvdrlbcefghsnuj---- TrpE [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I 22 4 51 aompkzyqvdrlbcefghsnuj---- PabA [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II 20 6 31 aomp--yqvdrlbcefghsnuj---- ArgH [E] COG0165 Argininosuccinate lyase 20 6 30 aomp--yqvdrlbcefghsnuj---- ArgG [E] COG0137 Argininosuccinate synthase 24 3 44 aompkzyqvdrlbcefghsnujxi-- Asd [E] COG0136 Aspartate-semialdehyde dehydrogenase 24 3 56 aompkzyqvdrlbcefghsnujxi-- LysC [E] COG0527 Aspartokinases 20 6 66 aom---yqvdrlbcefghsnujx--- IlvE [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase 20 6 41 aomp--yqvdrlbcefghsnuj---- CarB [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) 20 6 36 aomp--yqvdrlbcefghsnuj---- CarA [EF] COG0505 Carbamoylphosphate synthase small subunit 20 6 43 aomp-zyqvdrlb-efghsnuj---- PheA [E] COG1605 Chorismate mutase 23 4 38 aompkzyqvdrlbcefghsnuj-i-- AroC [E] COG0082 Chorismate synthase 19 7 72 -o-pkzy-vdrlbcefghsnuj---- MetC [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases 20 5 52 ao----yqvdrlbcefgh-nujxit- NifS [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes 20 6 63 -o-pkzyqvdrlbcefghsnuj---- CysK [E] COG0031 Cysteine synthase 19 7 45 a-mp--yqvdrlbcefghsnuj---- LysA [E] COG0019 Diaminopimelate decarboxylase 22 5 57 aompkz-qv-rlbcefghsnujxi-- DapA [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase 20 6 49 a-m-kzyqvdrlbcefghsnuj---- IlvD [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase 17 5 26 ------yqvdrlbcefghsnuj--t- ProA [E] COG0014 Gamma-glutamyl phosphate reductase 17 5 28 ------yqvdrlbcefghsnuj--t- ProB [E] COG0263 Glutamate 5-kinase 17 10 44 ao-pkzy-vd--bcef-h-nuj-i-- GdhA [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase 16 9 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0067 Glutamate synthase domain 1 16 9 30 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0069 Glutamate synthase domain 2 16 9 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0070 Glutamate synthase domain 3 19 7 30 aom---yqvdrlbcefghsnuj---- HisH [E] COG0118 Glutamine amidotransferase 23 3 64 aompkzyqvdrlbcefghsnujx--- GlnA [E] COG0174 Glutamine synthase 19 8 34 -o-pkzyqvdrlbcefg-sn-j-i-- GcvH [E] COG0509 Glycine cleavage system H protein (lipoate-binding) 16 10 48 -o-pkzyqvdr-bcef--sn-j---- GcvT [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase) 16 10 25 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain 16 10 24 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain 26 1 53 aompkzyqvdrlbcefghsnujxitw GlyA [E] COG0112 Glycine hydroxymethyltransferase 21 6 120 ao-pkzyq--rlbcefghsnuj-it- DadA [E] COG0665 Glycine/D-amino acid oxidases (deaminating) 19 7 31 aom---yqvdrlbcefghsnuj---- HisD [E] COG0141 Histidinol dehydrogenase 13 9 24 a-mpk-yqvdrlb-e-g--------- HIS2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family 22 4 54 aompkzyqvdrlbcefghsnuj---- HisC [E] COG0079 Histidinol-phosphate aminotransferase/Tyrosine aminotransferase 22 4 43 aompkzyqvdrlbcefghsnuj---- ThrA [E] COG0460 Homoserine dehydrogenase 19 7 30 -ompkzyqvdrlbce-ghs-uj---- ThrB [E] COG0083 Homoserine kinase 19 7 28 aom---yqvdrlbcefghsnuj---- HisB [E] COG0131 Imidazoleglycerol-phosphate dehydratase 19 7 30 aom---yqvdrlbcefghsnuj---- HisF [E] COG0107 Imidazoleglycerol-phosphate synthase 22 4 34 aompkzyqvdrlbcefghsnuj---- TrpC [E] COG0134 Indole-3-glycerol phosphate synthase 20 6 46 a-m-k-yqvdrlbcefghsnujx--- LeuB [E] COG0473 Isocitrate/isopropylmalate dehydrogenase 19 7 58 a-mpk-yqvdr-bcefghsnuj---- LeuA [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases 19 7 31 a-m-k-yqvdrlbcefghsnuj---- IlvC [EH] COG0059 Ketol-acid reductoisomerase 20 7 40 a-mpkzyqv-rlb-efghsnuj-i-- MetE [E] COG0620 Methionine synthase II (cobalamin-independent) 19 8 48 ---pkzyqvdrlbcefg-s-ujx-t- GltD [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases 22 5 79 aompkzyq-d--bcefghsnujxit- PutP [EHR] COG0591 Na+/proline, Na+/panthothenate symporters and related permeases 11 10 12 -o----y-vdrlb--f-h--uj---- MET17 [E] COG2873 O-acetylhomoserine sulfhydrylase 24 3 42 aompkzyqvdrlbcefghsnuj--tw ArgF [E] COG0078 Ornithine carbamoyltransferase 22 4 87 aompkzyqvdrlbcefghsnuj---- ArgD [E] COG0160 PLP-dependent aminotransferases 25 2 123 aompkzyqvdrlbcefghsnujxit- AvtA [E] COG0436 PLP-dependent aminotransferases 21 5 61 aompkzyqvdrlbcefghs-uj---- SerA [E] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases 19 7 28 aom---yqvdrlbcefghsnuj---- HisI [E] COG0139 Phosphoribosyl-AMP cyclohydrolase 18 6 27 -om---yqvdrlbcefghsnuj---- HisI [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase 22 5 33 aompkzyqvd-lbcefghsnuj-i-- TrpF [E] COG0135 Phosphoribosylanthranilate isomerase 19 7 28 aom---yqvdrlbcefghsnuj---- HisA [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 20 6 31 aomp--yqvdrlbcefghsnuj---- PheA [E] COG0077 Prephenate dehydratase 21 5 32 aomp-zyqvdrlbcefghsnuj---- TyrA [E] COG0287 Prephenate dehydrogenase 20 7 37 --mp-zyqvdrlbcefghsnuj--t- ProC [E] COG0345 Pyrroline-5-carboxylate reductase 21 5 54 -om-kzy-vdrlbcefghs-uj-itw CsdB [E] COG0520 Selenocysteine lyase 17 8 30 aompkzyqvd-lbc-fg---uj---- - [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase 23 4 45 aompkzyqvdrlbcefghsnuj-i-- AroE [E] COG0169 Shikimate 5-dehydrogenase 17 5 33 ------yqvdrlbcefghsnuj-i-- AroK [E] COG0703 Shikimate kinase 17 9 33 a-mpkzyqvdr-b-ef--snuj---- SpeE [E] COG0421 Spermidine synthase 21 5 103 a-mpkzyqvdrlbcefghsnuj---- IlvB [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] 19 6 47 -o-p-zy-vdrlbcefghsnujx--- IlvA [E] COG1171 Threonine dehydratase 19 7 88 ao-pkzy-vdrlb-efghsn-j---w Tdh [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 22 4 48 aompkzyqvdrlbcefghsnuj---- ThrC [E] COG0498 Threonine synthase 23 4 35 aompkzyqvdrlbcefghsnuj-i-- TrpA [E] COG0159 Tryptophan synthase alpha chain 21 6 32 aom-k-yqvdrlbcefghsnuj-i-- TrpB [E] COG0133 Tryptophan synthase beta chain 26 1 84 aompkzyqvdrlbcefghsnujxitw PepP [E] COG0006 Xaa-Pro aminopeptidase 16 10 41 aom---yqvd-lbce-gh--uj--t- UshA [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases 19 5 29 ao-p--yqvdrlbcefghsnuj---- PurH [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 20 6 55 -om-kzy-vdrlbcefgh-nuj--tw Apt [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins 23 4 57 ao--k-yqvdrlbcefghsnujxitw Adk [F] COG0563 Adenylate kinase and related kinases 21 5 42 aompk-yqvdrlbcefghsnuj---- PurB [F] COG0015 Adenylosuccinate lyase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurA [F] COG0104 Adenylosuccinate synthase 21 5 34 aompkzyqvdrlbcefg-snuj---- PyrB [F] COG0540 Aspartate carbamoyltransferase, catalytic chain 26 1 44 aompkzyqvdrlbcefghsnujxitw PyrG [F] COG0504 CTP synthase (UTP-ammonia lyase) 14 9 22 -o---zy-vdrlb-e-gh---j--tw Cdd [F] COG0295 Cytidine deaminase 18 8 53 aompkzyqvd--bcef-hs-uj---- SsnA [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases 16 6 36 ------yq-drlbcefghsn-jxi-- - [FJ] COG0590 Cytosine/adenosine deaminases 17 8 25 -omp-z-qvdrlbce-gh---j--tw DeoC [F] COG0274 Deoxyribose-phosphate aldolase 25 2 74 aompkzyq-drlbcefghsnujxitw Hit [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases 19 7 44 aompkzyqvdrlbcef--s-uj---- PyrC [F] COG0044 Dihydroorotase 22 4 42 aompkzyqvdrlbcefghsnuj---- PyrD [F] COG0167 Dihydroorotate dehydrogenase 16 5 31 ------yqvdr-bcefghsnujx--- GppA [FP] COG0248 Exopolyphosphatase 18 6 29 -o-p--yqvdrlbcefghsnuj---- PurN [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN 24 3 52 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0518 GMP synthase - Glutamine amidotransferase domain 24 3 37 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0519 GMP synthase - PP-ATPase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurF [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase 19 3 39 ------yqvdrlbcefghsnujxi-w Gmk [F] COG0194 Guanylate kinase 23 4 90 -ompkzyqvdrlbcefghsnuj-it- GuaB [F] COG0516 IMP dehydrogenase/GMP reductase 23 4 38 aompkzyq-dr-bcefghsnujxit- Ndk [F] COG0105 Nucleoside diphosphate kinase 23 4 40 aompkzyqvdrlbcefghsnuj-i-- PyrE [F] COG0461 Orotate phosphoribosyltransferase 22 4 36 aompkzyqvdrlbcefghsnuj---- PyrF [F] COG0284 Orotidine-5'-phosphate decarboxylase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurD [F] COG0151 Phosphoribosylamine-glycine ligase 21 5 33 aompk-yqvdrlbcefghsnuj---- PurM [F] COG0150 Phosphoribosylaminoimidazol (AIR) synthetase 17 7 26 -o-p--yqvdrlbcefghsn-j---- PurK [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 22 4 35 aompk-yqvdrlbcefghsnujx--- PurC [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase 21 5 32 aompk-yqvdrlbcefghsnuj---- PurE [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase 14 7 19 aompk--qvdrlbc------uj---- PurS [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain 24 3 52 aompkzyqvdrlbcefghsnuj--tw PrsA [FE] COG0462 Phosphoribosylpyrophosphate synthetase 12 8 19 -o-pkz-qv-r--c------u-xit- THY1 [F] COG1351 Predicted alternative thymidylate synthase 16 9 31 a-mpkzyqv-rlbcef--s--j---- Pnp [F] COG0005 Purine nucleoside phosphorylase 26 1 60 aompkzyqvdrlbcefghsnujxitw NrdA [F] COG0209 Ribonucleotide reductase alpha subunit 20 3 41 -o----yq-drlbcefghsnujxitw NrdF [F] COG0208 Ribonucleotide reductase beta subunit 26 1 48 aompkzyqvdrlbcefghsnujxitw Tmk [F] COG0125 Thymidylate kinase 21 5 32 -om-kzyqvdrlbcefgh-nuj--tw Upp [F] COG0035 Uracil phosphoribosyltransferase 13 6 26 -o----y-vd-lbce-gh-----itw Udk [F] COG0572 Uridine kinase 25 2 42 aompkz-qvdrlbcefghsnujxitw PyrH [F] COG0528 Uridylate kinase 24 3 38 aompkzyqvdrlbcefghsnuj-it- - [F] COG0127 Xanthosine triphosphate pyrophosphatase 15 7 30 ------yq--rlb-ef-hsnujxit- Dut [F] COG0756 dUTPase 15 10 42 a-mpk-yqv-rlb-efg--n----t- UbiB [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibB [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 19 8 30 a-mpkzyq-d--bcefgh-nujxi-- UbiX [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase 19 8 34 a-mpkzyq-d--bcefgh-nujxi-- UbiD [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases 21 6 42 aompkzyq-d--bcefghsnujxi-- UbiA [H] COG0382 4-hydroxybenzoate polyprenyltransferase 22 3 42 -o-p--yqvdrlbcefghsnujxitw FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase 22 4 35 -om--zyq-drlbcefghsnujxitw - [H] COG0212 5-formyltetrahydrofolate cyclo-ligase 17 5 33 ------yqvdrlbcefghsnuj-i-- FolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 19 8 53 --mpk-yq-dr-bcefghsnujxi-- BioF [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes 15 9 51 --m---yq-dr-b-efghsnuj-i-- BioA [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 16 8 34 --m---yqv-r-bcefghsnuj-i-- BioB [H] COG0502 Biotin synthase and related enzymes 23 4 38 aom-k-yqvdrlbcefghsnujxit- BirA [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase 21 6 32 aomp-zyq-dr-bcefghsnujxi-- HemB [H] COG0113 Delta-aminolevulinic acid dehydratase 26 1 45 aompkzyqvdrlbcefghsnujxitw CoaE [H] COG0237 Dephospho-CoA kinase 15 7 40 ------y-vdrlb-efghsn-j-i-w FolA [H] COG0262 Dihydrofolate reductase 23 4 44 aompkzyqvdrlbcefghsnuj-i-- FolP [H] COG0294 Dihydropteroate synthase 20 6 55 aompkzyq-dr-bcefghsnuj---- ThiF [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 19 3 34 ------yqvdrlbcefghsnuj-itw RibF [H] COG0196 FAD synthase 20 5 38 -o-p--yqvdrlbcefghsnujx-t- FolC [H] COG0285 Folylpolyglutamate synthase 19 6 41 a--p--yqvdrlbcefghsnuj-i-- RibA [H] COG0807 GTP cyclohydrolase II 25 2 78 aompkzyqvdrlbcefghsnujxit- IspA [H] COG0142 Geranylgeranyl pyrophosphate synthase 19 8 35 aomp-z-q-dr-bcefghsnuj-i-- AlsD [H] COG0001 Glutamate-1-semialdehyde aminotransferase 18 8 27 aomp-z-q-dr-bcefghsnu--i-- HemA [H] COG0373 Glutamyl-tRNA reductase 22 5 39 aompkzyqvdrlb-efghsnuj--t- ThiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 17 8 30 -o--kzyqvdr-bcefg-snuj---- PanB [H] COG0413 Ketopantoate hydroxymethyltransferase 17 8 27 -o---zyq-dr-bcefghsn-jxi-- LipA [H] COG0320 Lipoate synthase 15 9 42 -o-pkzyqv--lbcefg------i-w LplA [H] COG0095 Lipoate-protein ligase A 18 6 28 ---p--yqvdr-bcefghsnujxi-- UbiE [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis 23 4 41 aompkzyqvdrlbcefg-snuj--tw NadE [H] COG0171 NAD synthase 16 10 36 a---kzyqvdrlb-efgh--uj---- SIR2 [H] COG0846 NAD-dependent protein deacetylases, SIR2 family 19 7 32 aom-k-yqv-rlbcefghsnuj---- NadC [H] COG0157 Nicotinate-nucleotide pyrophosphorylase 16 6 32 ------yqv-rlbcefg-snuj--tw NadD [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase 23 4 37 ao-pkzyqvdrlbcefghsnuj--tw PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase 14 7 24 ------yqvdr-bcefg-snuj---- PanC [H] COG0414 Panthothenate synthetase 23 4 45 aompkzyqvdrlbcefghsnuj--t- Dfp [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase 21 6 33 aomp-zyq-dr-bcefghsnujxi-- HemC [H] COG0181 Porphobilinogen deaminase 18 6 29 ---p--yq-drlbcefghsnujxi-- HemH [H] COG0276 Protoheme ferro-lyase (ferrochelatase) 17 5 28 ------yqvdrlbcefghsnuj-i-- RibD [H] COG0117 Pyrimidine deaminase 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibD [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis 18 5 29 -o----yqvdrlbcefghsnuj-i-- RibC [H] COG0307 Riboflavin synthase alpha chain 21 6 34 aom--zyqvdrlbcefghsnuj-i-- RibH [H] COG0054 Riboflavin synthase beta-chain 14 6 21 aompkzyqv-r--c-f--s--j---- SAM1 [H] COG0499 S-adenosylhomocysteine hydrolase 18 4 34 ------yqvdrlbcefghsnuj--tw MetK [H] COG0192 S-adenosylmethionine synthetase 15 9 42 aomp-z-qvdr-bce-g---u--i-- ThiH [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes 17 9 24 aom-k--qvdr-bcefg-snuj---- ThiC [H] COG0422 Thiamine biosynthesis protein ThiC 17 7 27 ---p--yq-dr-bcefghsnujxi-- HemE [H] COG0407 Uroporphyrinogen-III decarboxylase 19 8 36 aomp--yq-dr-bcefghsnu-xi-- HemD [H] COG1587 Uroporphyrinogen-III synthase 18 4 41 ------yqvdrlbcefghsnujxi-- FabD [I] COG0331 (acyl-carrier-protein) S-malonyltransferase 20 2 81 ------yqvdrlbcefghsnujxitw PlsC [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase 17 9 41 --mp-zyq-drlbcefgh-nuj---- MmsB [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related proteins 18 4 59 ------yqvdrlbcefghsnujxi-- FabB [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase 20 6 120 aompkzy--drlbcefgh--ujx-t- PaaJ [I] COG0183 Acetyl-CoA acetyltransferases 21 6 58 ao--k-yqvdrlbcefghsnujxi-- AccA [I] COG0825 Acetyl-CoA carboxylase alpha subunit 20 2 59 ------yqvdrlbcefghsnujxitw AcpP [IQ] COG0236 Acyl carrier protein 21 5 165 aomp-zy--drlbcefghsnujxi-- CaiC [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 18 8 64 aomp-zyq-dr-bcefghs-uj---- Acs [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases 22 5 60 ao--k-yqvdrlbcefghsnujxit- AccB [I] COG0511 Biotin carboxyl carrier protein 21 6 70 aom---yq-drlbcefghsnujxit- AccC [I] COG0439 Biotin carboxylase 26 1 48 aompkzyqvdrlbcefghsnujxitw CdsA [I] COG0575 CDP-diglyceride synthetase 16 9 151 ao-p-zyq-drlb-efg-s--jx--- CaiD [I] COG1024 Enoyl-CoA hydratase/carnithine racemase 19 7 74 -om-k-yq-drlbcefghs-ujx-t- PgpB [I] COG0671 Membrane-associated phospholipid phosphatase 8 5 12 a-m-kzyqv-r--------------- INO1 [I] COG1260 Myo-inositol-1-phosphate synthase 25 2 71 aompkzyqv-rlbcefghsnujxitw PgsA [I] COG0558 Phosphatidylglycerophosphate synthase 17 9 31 aom---y--dr-b-efghsnujxi-- Psd [I] COG0688 Phosphatidylserine decarboxylase 14 9 24 aom---y---r-b--f--snujxit- PssA [I] COG1183 Phosphatidylserine synthase 18 7 62 a--p--y-v--lbcefghsnujxi-w Cls [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes 16 6 33 ------yqvdrlb-e-g--nujxitw AcpS [I] COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) 25 2 49 aompkzyqvdrlbcefghsnujxit- UppS [I] COG0020 Undecaprenyl pyrophosphate synthase 24 3 228 aompkzy-vdrlbcefghsnujx-tw CcmA [Q] COG1131 ABC-type multidrug transport system, ATPase component 21 4 204 -o--k-yqvdrlbcefghsnujxi-w MdlB [Q] COG1132 ABC-type multidrug/protein/lipid transport system, ATPase component 19 8 70 ao-pkzyqv-rlb-efg-snuj--t- PncA [Q] COG1335 Amidases related to nicotinamidase 23 4 481 ao-pkzyqvdrlbcefghsnujxi-- FabG [QR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 23 4 83 aom-kzyqvdrlbcefghsnuj--tw NorM [Q] COG0534 Na+-driven multidrug efflux pump 26 1 493 aompkzyqvdrlbcefghsnujxitw SmtA [QR] COG0500 SAM-dependent methyltransferases 20 6 129 aompkzy-vdrlbcefghs-uj---- - [R] COG0842 ABC-type multidrug transport system, permease component 23 4 121 aom--z-qvdrlbcefghsnujxitw PhnL [R] COG1136 ABC-type transport systems, involved in lipoprotein release, ATPase components 23 3 65 aompkzyqvdrlbcefghsnuj---w RimI [R] COG0456 Acetyltransferases 18 8 60 -om-k-y-vdrlbcefgh-nuj-i-- WbbJ [R] COG0110 Acetyltransferases (the isoleucine patch superfamily) 25 2 212 aompkzyqvdrlbcefghsnujxit- - [R] COG0517 CBS domains 19 7 45 a-mpkzyqvdrlbcef-h-n-jx--- - [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family 13 8 30 a-----yqvdrlb--f--snuj---- - [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase 26 1 81 aompkzyqvdrlbcefghsnujxitw ARC1 [R] COG0073 EMAP domain 15 6 37 aom-kz-qvdrlbc--g-------tw - [R] COG0618 Exopolyphosphatase-related proteins 19 7 28 -om-kz-qvdrlbcefghsn-j-i-- HflX [R] COG2262 GTPases 16 11 50 ao--kzy-vdrlb-efg-s--j-i-- - [R] COG1073 Hydrolases of the alpha/beta superfamily 17 8 28 aompkz--vdrlbce---s--j-it- - [R] COG0396 Iron-regulated ABC transporter ATPase subunit SufC 18 6 39 aompkzy-vdrlbce--h---j-it- ElaC [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 19 8 79 aompkzyqvdr-bcefg-s--j--t- - [R] COG0714 MoxR-like ATPases 18 9 31 aompk-yq--r-b-e-ghsnuj-i-w - [R] COG1881 Phospholipid-binding protein 13 9 18 -o-pkzyqvd-lb-e-----uj---- - [R] COG1832 Predicted CoA-binding protein 19 3 33 ------yqvd-lbcefghsnujxitw ThdF [R] COG0486 Predicted GTPase 20 2 35 ------yqvdrlbcefghsnujxitw Obg [R] COG0536 Predicted GTPase 26 1 49 aompkzyqvdrlbcefghsnujxitw - [R] COG0012 Predicted GTPase 19 5 33 aom-k-yqv--lb-efghsnujx--w - [R] COG0218 Predicted GTPases 14 7 31 aompk--qvd-lb-e-----u---tw - [R] COG1418 Predicted HD superfamily hydrolase 19 8 35 a--pk-yqvdrlb-efghsnuj-i-- - [R] COG1611 Predicted Rossmann fold nucleotide-binding protein 20 2 34 ------yqvdrlbcefghsnujxitw - [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase 22 5 64 aom---yqvdrlbcefghsnujxit- - [R] COG0042 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family 20 6 41 aompkzy-vdrlbcefghs-uj---- - [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold 18 6 62 -----zyqvdrlbcefghs-ujx-t- PqqL [R] COG0612 Predicted Zn-dependent peptidases 21 6 79 aompkzyqvdr-bcefg-snuj--t- - [R] COG0388 Predicted amidohydrolase 17 9 29 a--pkzy-v-r-bcefg-snuj---w - [R] COG0579 Predicted dehydrogenase 16 10 103 --mpk-yqvd-lbcefgh--uj---- MviM [R] COG0673 Predicted dehydrogenases and related proteins 9 4 14 a-mpkzyqv------------j---- - [R] COG1355 Predicted dioxygenase 16 5 27 ------yqvdrlbcefghsnuj---- - [R] COG0325 Predicted enzyme with a TIM-barrel fold 16 6 41 ------yqv-rlbcefghsn-jx-t- RssA [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily 19 8 85 -ompk-yqvdrlb-efghsn-j--t- - [R] COG1011 Predicted hydrolases of the HAD superfamily 21 6 90 aompkzy-vdrlbce-gh-n-j-itw Cof [R] COG0561 Predicted hydrolases of the HAD superfamily 22 4 276 ao-p-zyq-drlbcefghsnujx-tw MhpC [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 24 3 48 aompkzyqv-rlbcefghsnujx-tw - [R] COG0061 Predicted kinase 17 8 51 aompkz--vdrlbce---s--j-it- - [R] COG0719 Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufB 17 8 48 -om-kz-qvdrlbcefg----j-it- - [R] COG1266 Predicted metal-dependent membrane protease 21 6 71 aom-k--qvdrlbcefghsnujx-t- PerM [R] COG0628 Predicted permease 21 5 93 aompkz-qvdrlbcefghsnuj---- - [R] COG0730 Predicted permeases 16 8 55 ----k-y-vdrlbcefghsn-j-i-- - [R] COG0637 Predicted phosphatase/phosphohexomutase 21 6 53 aom-k-yq-drlbcefghsnuj--tw Gph [R] COG0546 Predicted phosphatases 18 9 43 -omp-z-q-dr-bcefghsnuj--t- FcbC [R] COG0824 Predicted thioesterase 21 6 77 aompkzyq-dr-bcefghs-uj--tw ThiJ [R] COG0693 Putative intracellular protease/amidase 19 6 30 aom--zyqvd---cefghsnuj-it- SurE [R] COG0496 Survival protein, predicted acid phosphatase 23 4 321 aompk-yqvd-lbcefghsnujxit- NrfG [R] COG0457 TPR-repeat-containing proteins 13 9 19 aom-k---vd-lbc-------jxit- BioY [R] COG1268 Uncharacterized ACR 21 2 82 -o----yqvdrlbcefghsnujxitw - [R] COG1253 Uncharacterized CBS domain-containing proteins 21 5 99 aompkzyqvdrlbcefgh---j--tw HcaD [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases 22 5 44 aompkzyqvdrlbcefghs-uj--t- GlpG [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) 17 5 30 -o----yqvdrlbcefg-snuj---w CinA [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) 22 4 157 aompkzyqvdrlbcefghsnuj---- GloB [R] COG0491 Zn-dependent hydrolases, including glyoxylases 16 8 27 aompkz-qvdr-bc--g--nuj---- SpoIVFB [R] COG1994 Zn-dependent proteases 18 6 29 aompkzyqvdr--cefg-s-uj---- - [S] COG0062 Uncharacterized ACR 18 7 28 aompk--qvdrlbc-f--sn-j--tw - [S] COG1354 Uncharacterized ACR 13 7 23 ------y-vd-lb-efgh-nu---tw - [S] COG1739 Uncharacterized ACR 18 7 38 aom-k-y--drlb-efgh-nu--itw - [S] COG0327 Uncharacterized ACR 14 8 23 a-m-kzyqvdr-bcefg--------- - [S] COG0432 Uncharacterized ACR 9 2 13 aompkzyqv----------------- - [S] COG2078 Uncharacterized ACR 11 5 16 aompk-yqv-r-bc------------ - [S] COG0011 Uncharacterized ACR 14 8 22 aom---yqvdrlbce-gh-------- - [S] COG0391 Uncharacterized ACR 13 11 31 aom-k--q-d---c-fg--nuj--t- - [S] COG1432 Uncharacterized ACR 20 2 37 ------yqvdrlbcefghsnujxitw - [S] COG0217 Uncharacterized ACR 12 7 19 aom-k--q-d-lbc---------itw - [S] COG1624 Uncharacterized ACR 13 10 23 a--pkzyqvdrl--ef-----j---- - [S] COG2110 Uncharacterized ACR related to the C-terminal domain of histone macroH2A1 LUCA1.5 Total number of events, gains and losses are 14276 7404 6872 Total inconsistency = 17978 733 COGs number of species/inconsistency (number of events)/number of genes 23 4 59 aompkz-qvdr-bcefghsnujxit- MiaB [J] COG0621 2-methylthioadenine synthetase 18 8 99 -o-pk-y-vdrlb-efgh-nujx--w RimL [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw AlaS [J] COG0013 Alanyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw ArgS [J] COG0018 Arginyl-tRNA synthetase 20 5 73 aom--zyqvdrlbc-f---nujxitw GatA [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases 20 5 34 aom--zyqvdrlbc-f---nujxitw GatB [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) 19 6 30 aom--z-qvdrlbc-f---nujxitw GatC [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit 20 2 35 ------yqvdrlbcefghsnujxitw AspS [J] COG0173 Aspartyl-tRNA synthetase 17 7 43 aompkzy--d-lbce-ghs-----tw AsnS [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases 25 2 44 ao-pkzyqvdrlbcefghsnujxitw CysS [J] COG0215 Cysteinyl-tRNA synthetase 12 8 19 ------yqvdrlb-efgh-n------ Dtd [J] COG1490 D-Tyr-tRNAtyr deacylase 26 1 50 aompkzyqvdrlbcefghsnujxitw KsgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) 26 1 85 aompkzyqvdrlbcefghsnujxitw TufB [JE] COG0050 GTPases - translation elongation factors 26 1 75 aompkzyqvdrlbcefghsnujxitw GlnS [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases 11 6 20 aompkzy--dr-------------tw GRS1 [J] COG0423 Glycyl-tRNA synthetase, class II 26 1 58 aompkzyqvdrlbcefghsnujxitw HisS [J] COG0124 Histidyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw IleS [J] COG0060 Isoleucyl-tRNA synthetase 26 1 48 aompkzyqvdrlbcefghsnujxitw LeuS [J] COG0495 Leucyl-tRNA synthetase 17 4 37 ------yqvdrlbcefghsnu--i-w LysU [J] COG1190 Lysyl-tRNA synthetase class II 26 1 55 aompkzyqvdrlbcefghsnujxitw Map [J] COG0024 Methionine aminopeptidase 20 2 40 ------yqvdrlbcefghsnujxitw Fmt [J] COG0223 Methionyl-tRNA formyltransferase 26 1 48 aompkzyqvdrlbcefghsnujxitw MetG [J] COG0143 Methionyl-tRNA synthetase 20 2 37 ------yqvdrlbcefghsnujxitw Pth [J] COG0193 Peptidyl-tRNA hydrolase 26 1 46 aompkzyqvdrlbcefghsnujxitw PheS [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit 26 1 46 aompkzyqvdrlbcefghsnujxitw PheT [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit 10 3 15 aompkzyqv-r--------------- GCD14 [J] COG2519 Predicted SAM-dependent methyltransferase involved in tRNA-Met maturation 25 2 58 aompk-yqvdrlbcefghsnujxitw HemK [J] COG2890 Predicted rRNA or tRNA methylase 20 2 39 ------yqvdrlbcefghsnujxitw TrmU [J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain 26 1 47 aompkzyqvdrlbcefghsnujxitw ProS [J] COG0442 Prolyl-tRNA synthetase 20 2 36 ------yqvdrlbcefghsnujxitw PrfA [J] COG0216 Protein chain release factor A 19 3 41 ------yqvdrlbcefghsnujxit- PrfB [J] COG1186 Protein chain release factor B 26 1 45 aompkzyqvdrlbcefghsnujxitw TruB [J] COG0130 Pseudouridine synthase 25 2 46 aompk-yqvdrlbcefghsnujxitw TruA [J] COG0101 Pseudouridylate synthase (tRNA psi55) 20 2 101 ------yqvdrlbcefghsnujxitw RluA [J] COG0564 Pseudouridylate synthases, 23S RNA-specific 25 2 54 aompkzyqvdrlbcefghsn-jxitw SUA5 [J] COG0009 Putative translation factor (SUA5) 19 6 76 -o--kzyqvdrlbcefghsnuj---- TdcF [J] COG0251 Putative translation initiation inhibitor 23 4 38 aompkz-qvd-lbcefghsnujxit- Tgt [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase 18 8 31 a-mpkzyq-dr-b-efghsn-jx--- Rph [J] COG0689 RNase PH 17 9 35 -o--kz-qv-r-bcefghsn-jxi-- CafA [J] COG1530 Ribonucleases G and E 26 1 47 aompkzyqvdrlbcefghsnujxitw RplA [J] COG0081 Ribosomal protein L1 26 1 49 aompkzyqvdrlbcefghsnujxitw RplJ [J] COG0244 Ribosomal protein L10 26 1 49 aompkzyqvdrlbcefghsnujxitw RplK [J] COG0080 Ribosomal protein L11 26 1 48 aompkzyqvdrlbcefghsnujxitw RplM [J] COG0102 Ribosomal protein L13 26 1 47 aompkzyqvdrlbcefghsnujxitw RplN [J] COG0093 Ribosomal protein L14 26 1 45 aompkzyqvdrlbcefghsnujxitw RplO [J] COG0200 Ribosomal protein L15 26 1 48 aompkzyqvdrlbcefghsnujxitw RplP [J] COG0197 Ribosomal protein L16/L10E 20 2 35 ------yqvdrlbcefghsnujxitw RplQ [J] COG0203 Ribosomal protein L17 26 1 44 aompkzyqvdrlbcefghsnujxitw RplR [J] COG0256 Ribosomal protein L18 20 2 35 ------yqvdrlbcefghsnujxitw RplS [J] COG0335 Ribosomal protein L19 26 1 45 aompkzyqvdrlbcefghsnujxitw RplB [J] COG0090 Ribosomal protein L2 26 1 48 aompkzyqvdrlbcefghsnujxitw RplV [J] COG0091 Ribosomal protein L22 26 1 43 aompkzyqvdrlbcefghsnujxitw RplW [J] COG0089 Ribosomal protein L23 26 1 44 aompkzyqvdrlbcefghsnujxitw RplX [J] COG0198 Ribosomal protein L24 20 2 35 ------yqvdrlbcefghsnujxitw RpmA [J] COG0211 Ribosomal protein L27 20 2 35 ------yqvdrlbcefghsnujxitw RpmB [J] COG0227 Ribosomal protein L28 26 1 44 aompkzyqvdrlbcefghsnujxitw RpmC [J] COG0255 Ribosomal protein L29 26 1 46 aompkzyqvdrlbcefghsnujxitw RplC [J] COG0087 Ribosomal protein L3 22 5 39 aompkzyqvdrlb-efghsn-jx-t- RpmD [J] COG1841 Ribosomal protein L30/L7E 19 3 33 ------yqvd-lbcefghsnujxitw RpmF [J] COG0333 Ribosomal protein L32 20 2 40 ------yqvdrlbcefghsnujxitw RpmG [J] COG0267 Ribosomal protein L33 20 2 34 ------yqvdrlbcefghsnujxitw RpmH [J] COG0230 Ribosomal protein L34 20 2 34 ------yqvdrlbcefghsnujxitw RpmI [J] COG0291 Ribosomal protein L35 20 2 39 ------yqvdrlbcefghsnujxitw RpmJ [J] COG0257 Ribosomal protein L36 26 1 47 aompkzyqvdrlbcefghsnujxitw RplD [J] COG0088 Ribosomal protein L4 26 1 47 aompkzyqvdrlbcefghsnujxitw RplE [J] COG0094 Ribosomal protein L5 26 1 47 aompkzyqvdrlbcefghsnujxitw RplF [J] COG0097 Ribosomal protein L6 20 2 36 ------yqvdrlbcefghsnujxitw RplL [J] COG0222 Ribosomal protein L7/L12 19 3 35 ------yqvdrlbcefghsnujxit- RpsA [J] COG0539 Ribosomal protein S1 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsJ [J] COG0051 Ribosomal protein S10 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsK [J] COG0100 Ribosomal protein S11 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsL [J] COG0048 Ribosomal protein S12 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsM [J] COG0099 Ribosomal protein S13 26 1 50 aompkzyqvdrlbcefghsnujxitw RpsN [J] COG0199 Ribosomal protein S14 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsO [J] COG0184 Ribosomal protein S15P/S13E 20 2 35 ------yqvdrlbcefghsnujxitw RpsP [J] COG0228 Ribosomal protein S16 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsQ [J] COG0186 Ribosomal protein S17 20 2 36 ------yqvdrlbcefghsnujxitw RpsR [J] COG0238 Ribosomal protein S18 26 1 45 aompkzyqvdrlbcefghsnujxitw RpsS [J] COG0185 Ribosomal protein S19 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsB [J] COG0052 Ribosomal protein S2 26 1 44 aompkzyqvdrlbcefghsnujxitw RpsC [J] COG0092 Ribosomal protein S3 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsD [J] COG0522 Ribosomal protein S4 and related proteins 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsE [J] COG0098 Ribosomal protein S5 20 2 35 ------yqvdrlbcefghsnujxitw RpsF [J] COG0360 Ribosomal protein S6 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsG [J] COG0049 Ribosomal protein S7 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsH [J] COG0096 Ribosomal protein S8 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsI [J] COG0103 Ribosomal protein S9 20 2 36 ------yqvdrlbcefghsnujxitw Frr [J] COG0233 Ribosome recycling factor 17 7 45 ----k-yqv-rlbcefghsnuj-i-- TrmA [J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase 26 1 46 aompkzyqvdrlbcefghsnujxitw SerS [J] COG0172 Seryl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw ThrS [J] COG0441 Threonyl-tRNA synthetase 26 1 80 aompkzyqvdrlbcefghsnujxitw FusA [J] COG0480 Translation elongation and release factors (GTPases) 26 1 52 aompkzyqvdrlbcefghsnujxitw Efp [J] COG0231 Translation elongation factor P/translation initiation factor eIF-5A 26 1 49 aompkzyqvdrlbcefghsnujxitw InfB [J] COG0532 Translation initiation factor 2 (GTPase) 26 1 46 aompkzyqvdrlbcefghsnujxitw InfA [J] COG0361 Translation initiation factor IF-1 13 8 17 a-mpkzyqv---bc-f--s--j---- GCN3 [J] COG0182 Translation initiation factor eIF-2B alpha subunit 26 1 49 aompkzyqvdrlbcefghsnujxitw TrpS [J] COG0180 Tryptophanyl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw TyrS [J] COG0162 Tyrosyl-tRNA synthetase 26 1 45 aompkzyqvdrlbcefghsnujxitw ValS [J] COG0525 Valyl-tRNA synthetase 21 3 68 a-----yqvdrlbcefghsnujxitw SpoU [J] COG0566 rRNA methylases 21 6 54 aom-kzy-vdrlbcefghsnuj-i-- Sun [J] COG0144 tRNA and rRNA cytosine-C5-methylases 19 3 32 ------yqvdrlbcefghsnujxit- MiaA [J] COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase 19 3 50 ------yqvdrlbcefghsnujxit- PcnB [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase 26 1 46 aompkzyqvdrlbcefghsnujxitw RpoA [K] COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw RpoB [K] COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) 26 1 63 aompkzyqvdrlbcefghsnujxitw RpoC [K] COG0086 DNA-directed RNA polymerase beta' subunit/160 kD subunit (split gene in archaea and Syn) 24 3 38 aompkzyqvdrlbcefghsnujx-t- RpoZ [K] COG1758 DNA-directed RNA polymerase subunit K/omega 19 4 48 -o----yqvd-lbcefghsnuj-itw VacB [K] COG0557 Exoribonucleases 24 3 309 aompkzyqvdrlbcefghsnuj-i-w WecD [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases 16 10 35 aompkz--vdrlb-e---s--j-it- TroR [K] COG1321 Mn-dependent transcriptional regulator 14 6 22 aompkzy-vd-lbc------u---t- - [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP 21 5 148 aompkz-qvdrlbcefghsnuj---- ArsR [K] COG0640 Predicted transcriptional regulators 15 11 42 aomp---qv---bcefgh-nuj---- SirA [K] COG0425 Predicted transcriptional regulators 20 7 57 aom-kz-q-drlb-efg-snujxit- Spo0J [K] COG1475 Predicted transcriptional regulators 19 6 74 ao-pkzy-vdrlbcefghs----i-w HepA [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family 26 1 48 aompkzyqvdrlbcefghsnujxitw NusG [K] COG0250 Transcription antiterminator 25 2 47 aompkz-qvdrlbcefghsnujxitw NusA [K] COG0195 Transcription terminator 20 6 307 aom-k--qvdrlbcefghsnuj---w AcrR [K] COG1309 Transcriptional regulator 17 9 149 aompkz--vdrlb-efg-sn-j---- MarR [K] COG1846 Transcriptional regulators 16 8 73 ao-p-z-qvdrlbce-gh---j--t- NagC [K] COG1940 Transcriptional regulators 14 12 63 ---pkzy-vdrlb-efgh---j---- ARO8 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs 20 2 43 ------yqvdrlbcefghsnujxitw Rnc [K] COG0571 dsRNA-specific ribonuclease 26 1 61 aompkzyqvdrlbcefghsnujxitw Exo [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 16 10 40 aompkzyq--r-b--fgh-nuj---- CDC9 [L] COG1793 ATP-dependent DNA ligase 16 8 21 aompkz-qvd-lbcefg-------t- SbcC [L] COG0419 ATPase involved in DNA repair 25 2 75 aompkzyqvdrlbcefghsnu-xitw HolB [L] COG0470 ATPase involved in DNA replication 23 2 63 ao-p--yqvdrlbcefghsnujxitw GyrA [L] COG0188 DNA gyrase (topoisomerase II) A subunit 23 2 62 ao-p--yqvdrlbcefghsnujxitw GyrB [L] COG0187 DNA gyrase (topoisomerase II) B subunit 18 5 34 -o----yqvd-lbcefghsn-jxit- MutL [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) 15 10 41 -ompk---vd-lb-e-ghsnuj---- - [L] COG0863 DNA modification methylase 19 3 31 ------yqvdrlbcefghsnujxit- PolA [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains 26 1 47 aompkzyqvdrlbcefghsnujxitw DnaN [L] COG0592 DNA polymerase III beta subunit 21 4 63 a--p--yqvdrlbcefghsnujxit- DnaQ [L] COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonucleases 25 2 46 aompkz-qvdrlbcefghsnujxitw DnaG [L] COG0358 DNA primase (bacterial type) 18 6 27 aompkzyqvdrlbcefg-------t- SbcD [L] COG0420 DNA repair exonuclease 14 9 27 -ompkzyqv-r-b-e-g------i-w Nfo [L] COG0648 Endonuclease IV 19 7 38 a-mp--y--drlbcefghsnujx-t- XthA [L] COG0708 Exonuclease III 25 2 219 aompkz-qvdrlbcefghsnujxitw XerC [L] COG0582 Integrase 22 5 47 aompkzyqv-rlb-efghsnuj-it- Ada [L] COG0350 Methylated DNA-protein cysteine methyltransferase 23 3 58 --m-kzyqvdrlbcefghsnujxitw TatD [L] COG0084 Mg-dependent DNase 12 11 24 -om-k-yq----b--f-h-nuj---w - [L] COG1525 Micrococcal nuclease (thermonuclease) homologs 11 8 17 -om-k--qvd-lbc------u---t- - [L] COG1193 MutS-like ATPases involved in mismatch repair, family 1 19 6 42 -o-p--yqvd-lbcefghsn-jxit- MutS [L] COG0249 MutS-like ATPases involved in mismatch repair, family 2 24 3 198 aomp-zyqvdrlbcefghsnujxit- MutT [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes 25 2 47 aompkzyqvdrlbcefghsnujxit- Nth [L] COG0177 Predicted EndoIII-related endonuclease 13 9 88 -ompk--qvdr--ce---s-u---t- - [L] COG0675 Predicted transposases 17 9 36 -ompkzyq--rlb-efghsn-j---- DinG [L] COG1199 Rad3-related DNA helicases 26 1 62 aompkzyqvdrlbcefghsnujxitw RecA [L] COG0468 RecA/RadA recombinase 16 6 31 -o----y--dr-bcefghsnujx-t- RnhA [L] COG0328 Ribonuclease HI 25 2 39 aompkzyqvdrlbcefghsnujxit- RnhB [L] COG0164 Ribonuclease HII 20 2 50 ------yqvdrlbcefghsnujxitw Ssb [L] COG0629 Single-stranded DNA-binding protein 22 5 48 aompk--qvd-lbcefghsnujxit- RecJ [L] COG0608 Single-stranded DNA-specific exonuclease 23 4 78 -omp--yqvdrlbcefghsnujxitw UvrD [L] COG0210 Superfamily I DNA and RNA helicases 15 9 42 aompk-yqv-r--cef--s-u----w - [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits 21 6 165 a-mp--yq-drlbcefghsnujx-tw SrmB [LKJ] COG0513 Superfamily II DNA and RNA helicases 26 1 59 aompkzyqvdrlbcefghsnujxitw TopA [L] COG0550 Topoisomerase IA 15 6 26 ------y-vdrlb-efghsnuj---w - [L] COG2256 Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase 18 9 34 ao-pkz-qvdrl-c--gh-nujx-t- - [L] COG1573 Uracil-DNA glycosylase 18 6 40 aompk---v--lb-efghsnu--itw TopA [L] COG0551 Zn-finger domain associated with topoisomerase type I 20 7 92 -ompk--q-dr-bcefg-snujxitw Soj [D] COG1192 ATPases involved in chromosome partitioning 22 4 55 aompkzyqvdr-bcefghsnujx--- Mrp [D] COG0489 ATPases involved in chromosome partitioning 12 12 36 aom-k--qv-r-b--fg---u---t- - [D] COG0455 ATPases involved in chromosome partitioning 23 4 57 aompk--qvdrlbcefghsnujx-tw FtsZ [D] COG0206 Cell division GTPase 19 6 41 aompk-yqvdrlbc-f--sn-j--tw Smc [D] COG1196 Chromosome segregation ATPases 17 7 46 a-mp--yqv---b-efghs-ujxit- MreB [D] COG1077 HSP70 class molecular chaperones involved in cell morphogenesis 18 7 32 -om-k-yqvdr-bcefghsnuj---- CrcB [D] COG0239 Integral membrane protein possibly involved in chromosome condensation 19 3 34 ------yqvd-lbcefghsnujxitw GidA [D] COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division 18 6 36 ----k-yqvdr-bcefghsnujxi-- Maf [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation 26 1 79 aompkzyqvdrlbcefghsnujxitw MesJ [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control 17 4 34 ------yqvd--b-efghsnujxitw Lon [O] COG0466 ATP-dependent Lon protease, bacterial type 20 2 50 ------yqvdrlbcefghsnujxitw HflB [O] COG0465 ATP-dependent Zn proteases 19 3 32 ------yqvdrlbcefghsnujxit- ClpX [O] COG1219 ATP-dependent protease Clp, ATPase subunit 21 3 81 --m---yqvdrlbcefghsnujxitw ClpA [O] COG0542 ATPases with chaperone activity, ATP-binding subunit 26 1 80 aompkzyqvdrlbcefghsnujxitw GroL [O] COG0459 Chaperonin GroEL (HSP60 family) 20 2 38 ------yqvdrlbcefghsnujxitw GroS [O] COG0234 Co-chaperonin GroES (HSP10) 18 6 33 -om---y--drlbcefghsnuj--tw - [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase 20 7 57 aom-k-y-vdrlbcefghsn-jx-t- GrxC [O] COG0695 Glutaredoxin and related proteins 24 3 82 aompkzyqvdrlbcefghsnujx-t- HflC [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs 26 1 47 aompkzyqvdrlbcefghsnujxitw QRI7 [O] COG0533 Metal-dependent proteases with possible chaperone activity 23 4 93 -omp--yqvdrlbcefghsnujxitw DnaK [O] COG0443 Molecular chaperone 19 7 52 aompkzyqvdr-bcefg-s--jx--- IbpA [O] COG0071 Molecular chaperone (small heat shock protein) 23 4 40 -omp--yqvdrlbcefghsnujxitw GrpE [O] COG0576 Molecular chaperone GrpE (heat shock protein) 23 4 115 -omp--yqvdrlbcefghsnujxitw DnaJ [O] COG0484 Molecular chaperones (contain C-terminal Zn finger domain) 18 8 37 aompk--q---lbcefghsnujx--- NrdG [O] COG0602 Organic radical activating enzymes 17 5 68 ------yqvd-lbcefghsnujx-t- SurA [O] COG0760 Parvulin-like peptidyl-prolyl isomerase 18 6 38 -om---y--drlbcefghsnuj--tw MsrA [O] COG0225 Peptide methionine sulfoxide reductase 17 7 58 -om---y--drlbcefghsnuj--t- PpiB [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family 24 3 54 aompkzyqvdrlbcefghs-ujxit- AhpC [O] COG0450 Peroxiredoxin 18 7 40 -o-p-zyqvdr-bcefghsnuj---- Bcp [O] COG1225 Peroxiredoxin 20 7 72 aompkzyqv-r-b-efghs-ujx-t- HslV [O] COG0638 Proteasome protease subunit 17 8 37 ao-----q-dr-bcefghsnujxi-- DsbG [O] COG1651 Protein-disulfide isomerase 17 7 68 ao---zyq-drlbc-fg-snuj---w AprE [O] COG1404 Subtilisin-like serine proteases 26 1 239 aompkzyqvdrlbcefghsnujxitw TrxA [OC] COG0526 Thiol-disulfide isomerase and thioredoxins 26 1 76 aompkzyqvdrlbcefghsnujxitw TrxB [O] COG0492 Thioredoxin reductase 14 10 29 ao----y-----bcefghs-ujxi-- - [O] COG0694 Thioredoxin-like proteins and domains 21 4 81 -om---yqvdrlbcefghsnujxit- DegQ [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain 12 10 17 -o---zyq-dr-bc-f--s--jx--- CtaA [O] COG1612 Uncharacterized protein required for cytochrome oxidase assembly 21 5 76 aompkzyq-drlbcefghsnuj---- HtpX [O] COG0501 Zn-dependent protease with chaperone function 9 10 31 ------yq-dr---efg---uj---- Cfa [M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases 23 4 43 -ompkzyqvdrlbcefghsnuj-it- GlmS [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains 25 2 238 aompkzyqvdrlbcefghsnujx-tw WcaA [M] COG0463 Glycosyltransferases involved in cell wall biogenesis 13 11 21 ao--k--qvd---cefg-s-uj---- CpsB [M] COG0836 Mannose-1-phosphate guanylyltransferase 22 5 162 aompk-yqvdrlbcefghsnuj--t- WcaG [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 19 8 56 aompkzyq-dr-bc-f-hsnuj--t- GCD1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylases involved in lipopolysaccharide biosynthesis/translation initiation factor eIF2B subunits 17 9 30 aom-k--q--rlbcefghs-ujx--- Ugd [M] COG1004 Predicted UDP-glucose 6-dehydrogenase 24 3 260 aompkzyqvdrlbcefghsnujx-t- RfaG [M] COG0438 Predicted glycosyltransferases 24 3 52 aompkz-qvdrlbcefghsnujxit- - [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1 13 9 54 -o----yq-d-lbcefghs--j---- - [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases 16 4 40 ------yqvd---cefghsnujxit- - [M] COG0729 Predicted outer membrane protein 17 7 29 a-m-kzyq----b-efghsnujxi-- GutQ [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation 22 5 80 aompkz-qvdrlbcefg-snujx-t- MscS [M] COG0668 Small-conductance mechanosensitive channel 21 4 56 --m-k-yqvdrlbcefghsnujxit- Rfe [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase 15 8 30 --m---yq-d-lbcefgh-nuj---w GalE [M] COG1087 UDP-glucose 4-epimerase 18 8 26 aompkz-q-drlbcef--sn-jx--- RfbD [M] COG1091 dTDP-4-dehydrorhamnose reductase 17 9 32 aompkz--vdrlbcef--sn-j---- RfbA [M] COG1209 dTDP-glucose pyrophosphorylase 14 13 30 ao--k---vd--bcefg-s-uj--t- CheA [N] COG0643 Chemotaxis protein histidine kinase and related kinases 12 12 23 ao--k---v---b-efg-s-uj--t- CheB [NT] COG2201 Chemotaxis response regulator CheB, consists of CheY-like receiver domain and a methylesterase (demethylase) domain 13 14 53 ao--k---v---bcefg-s-uj--t- CheW [N] COG0835 Chemotaxis signal transduction protein 20 2 35 ------yqvdrlbcefghsnujxitw LepA [N] COG0481 Membrane GTPase LepA 14 13 207 ao--k---vd--bcefg-s-uj--t- Tar [N] COG0840 Methyl-accepting chemotaxis protein 11 13 26 ao--k---v---b-efg---uj--t- CheR [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins 23 4 56 aompkz-qvdr-bcefghsnujxit- SppA [NO] COG0616 Periplasmic serine proteases (ClpP class) 20 6 35 -om-k--qvdr-bcefghsnujxit- SecD [N] COG0342 Preprotein translocase subunit SecD 20 6 32 -om-k--qvdr-bcefghsnujxit- SecF [N] COG0341 Preprotein translocase subunit SecF 26 1 46 aompkzyqvdrlbcefghsnujxitw SecY [N] COG0201 Preprotein translocase subunit SecY 20 2 40 ------yqvdrlbcefghsnujxitw YidC [N] COG0706 Preprotein translocase subunit YidC 18 7 31 ao-p-z-q-dr-bcefghsnujx--- TatC [N] COG0805 Sec-independent protein secretion pathway component TatC 18 7 51 ao-p-z-q-dr-bcefghsnujx--- TatA [N] COG1826 Sec-independent protein secretion pathway components 25 2 68 aompkzyqvdrlbcefghsnujxit- LepB [N] COG0681 Signal peptidase I 19 7 33 aom-kz-qvd-lbcefghsnuj---- PppA [N] COG1989 Signal peptidase, cleaves prepilin-like proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw Ffh [N] COG0541 Signal recognition particle GTPase 26 1 46 aompkzyqvdrlbcefghsnujxitw FtsY [N] COG0552 Signal recognition particle GTPase 12 10 35 ao--kz--vd-lb--f-----j--tw Med [N] COG1744 Surface lipoprotein 13 7 23 ------yq--r--cefghs-ujxi-- CysQ [P] COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase 19 7 91 aompkz--vdrlbcefgh-nuj---- FecB [P] COG0614 ABC-type Fe3+-siderophores transport systems, periplasmic components 22 5 46 aom-kz-qvdrlbcefgh-nujxit- ZnuA [P] COG0803 ABC-type Mn/Zn transport system, periplasmic Mn/Zn-binding (lipo)protein (surface adhesin A) 21 6 41 aom-kz-qvd-lbcefgh-nujxit- ZnuC [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component 22 5 49 aom-kz-qvdrlbcefgh-nujxit- ZnuB [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components 19 7 70 aompk---vdrlbcefgh-nuj---w FepC [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components 19 7 103 aompkz--vd-lbcefgh-nuj---w BtuC [PH] COG0609 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components 16 7 51 aom-kz--vdrlbce-gh------tw CbiO [P] COG1122 ABC-type cobalt transport system, ATPase component 17 9 34 aompkz-q-dr-bcefgh--uj---- ModA [P] COG0725 ABC-type molybdate transport system, periplasmic component 12 12 62 a-----y-vd--bcefgh---j-i-- TauA [P] COG0715 ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components 21 6 38 aom-kz-qvdrlbcefghs-uj--tw PstB [P] COG1117 ABC-type phosphate transport system, ATPase component 21 6 46 aom-kz-qvdrlbcefghs-uj--tw PstS [P] COG0226 ABC-type phosphate transport system, periplasmic component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstA [P] COG0581 ABC-type phosphate transport system, permease component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstC [P] COG0573 ABC-type phosphate transport system, permease component 19 7 55 aompkz-q-dr-bcefghsnuj---- CysU [P] COG0555 ABC-type sulfate/molybdate transport systems, permease components 9 10 13 a---kzyq-d--bc------u----- MET3 [P] COG2046 ATP sulfurylase 15 11 23 a---kzyq-dr-bcefg-s-uj---- CysC [P] COG0529 Adenylylsulfate kinase and related kinases 17 9 38 a-mp--yqvdrlbcef--sn-j---w AmtB [P] COG0004 Ammonia permeases 14 7 25 aompk-yqv---bce-gh------t- ECM27 [P] COG0530 Ca2+/Na+ antiporter 24 3 89 aompkzyqvdrlbcefgh-nuj-itw ZntA [P] COG2217 Cation transport ATPases 18 8 46 aompkzyq-drlbce-gh-n-j---- EriC [P] COG0038 Chloride channel protein EriC 15 8 28 ----k-yqvdrlb-ef-hsnuj---- CzcD [P] COG1230 Co/Zn/Cd efflux system component 16 8 30 ao-p-zyqvd-lbc-f-h-nu----w CopZ [P] COG2608 Copper chaperone 10 11 20 ------yq-dr-b-e-gh-n-j---- SodC [P] COG2032 Cu/Zn superoxide dismutase 17 8 50 -om-k-yq-d-lbcefghsnu--i-- CitT [P] COG0471 Di- and tricarboxylate transporters 12 12 51 -o-p--y-vdr-bcef--s--j---- HcaA1 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases 13 13 21 a----zy-v---bcef-h-nu-x-t- FTR1 [P] COG0672 High-affinity iron permease 20 6 46 aom-kz-qvdrlbcefgh-nu---tw TrkA [P] COG0569 K+ transport systems, NAD-binding component 22 5 60 a-mpkzyq-drlbcefghsnujx-t- KefB [P] COG0475 Kef-type K+ transport systems, membrane components 24 2 79 aompkzyqvdrlbcefghsnujx--w Kch [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component 18 8 47 a-m-k-yqvdrlbcefghs-uj---- CorA [P] COG0598 Mg2+ and Co2+ transporters 20 7 50 aompkz-qvdrlbcefg-s--j--tw PhoU [P] COG0704 Phosphate uptake regulator 18 9 50 aompk-y-vdr-b-efgh-nuj-i-- PitA [P] COG0306 Phosphate/sulphate permeases 21 6 36 aom-kzyqvdrlbcefgh--ujx-t- MMT1 [P] COG0053 Predicted Co/Zn/Cd cation transporters 14 9 23 -om-kzyqvdr---ef---nu---t- - [P] COG0428 Predicted divalent heavy-metal cations transporter 21 6 95 aomp--yq-drlbcefghsnujx-t- PspE [P] COG0607 Rhodanese-related sulfurtransferases 13 9 37 ------yq--rlbcefgh--uj-i-- SUL1 [P] COG0659 Sulfate permease and related transporters (MFS superfamily) 13 10 25 a-----yq-dr-bcefg-sn-j---- CysI [P] COG0155 Sulfite reductase hemoprotein beta-component 22 5 49 -omp-zyq-drlbcefghsnujxit- SodA [P] COG0605 Superoxide dismutase 20 6 37 aom-kzyqvd-lbcefgh-nu---tw TrkG [P] COG0168 Trk-type K+ transport systems, membrane components 20 7 334 aom-k-y-vdrlbcefghs-ujx-t- CheY [T] COG0784 CheY-like receiver domains 14 11 41 aom-kzyq-d--bc-fg--n-j---- AcuC [TQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein 20 6 79 aompkzy-vd-lbcefghsnuj---- ApaH [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases 14 12 64 aom---yqvdr-bcefg----j---- FhlA [T] COG2203 GAF domain 17 10 210 aom----qvdr-bcefg-s-uj-it- AtoS [T] COG2202 PAS/PAC domain 14 8 43 ---p--yq-drlbc-f--s-uj-i-w PTC1 [T] COG0631 Protein serine/threonine phosphatases 18 8 42 aom---yq-drlbcefghsnuj---- Wzb [T] COG0394 Protein-tyrosine-phosphatase 11 4 46 aompkzyqv----c-------j---- RAD55 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction 22 5 549 aom---yqvdrlbcefghsnujxit- BaeS [T] COG0642 Sensory transduction histidine kinases 18 8 297 -o-p-zyq-drlbcefghs--j-i-w SPS1 [T] COG0515 Serine/threonine protein kinases 20 6 116 aompkzyq-drlbcefgh-n-jx--- UspA [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins 18 4 90 ------yqvdrlbcefghsnuj-it- Crp [T] COG0664 cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 16 9 30 -o-p-zyq-drlb-efg-sn-jx--- AcnA [C] COG1048 Aconitase A 16 5 35 aompkzyqv--lb-efgh---j---- EutG [C] COG1454 Alcohol dehydrogenase IV 17 9 94 aompkz-q-dr-bcefgh--uj---- BisC [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing 22 4 51 aomp-zyqvdrlbcefghsnujx--- GltA [C] COG0372 Citrate synthase 16 8 30 -o-p-zyq-dr-bc-fg-snujx--- QcrB [C] COG1290 Cytochrome b subunit of the bc complex 16 9 34 ao-p---q--rlbcefgh--ujxi-- CydA [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 16 8 56 aompkzyqv-r--cef--sn-j---- FixC [C] COG0644 Dehydrogenases (flavoproteins) 19 6 77 -o-p-zy--drlbcefghsn-jxi-w AceF [C] COG0508 Dihydrolipoamide acyltransferases 23 4 97 aomp-zyqvdrlbcefghsn-jxi-w Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes 14 11 32 ao-p-zy-vdr-b-ef--sn-j---- FixB [C] COG2025 Electron transfer flavoprotein alpha-subunit 14 11 31 ao-p-zy-vdr-b-ef--sn-j---- FixA [C] COG2086 Electron transfer flavoprotein beta-subunit 17 4 29 ------yqv-rlbcefghsnujx--w AtpB [C] COG0356 F0F1-type ATP synthase a subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpA [C] COG0056 F0F1-type ATP synthase alpha subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpD [C] COG0055 F0F1-type ATP synthase beta subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw AtpE [C] COG0636 F0F1-type ATP synthase c subunit/Archaeal/vacuolar-type H+-ATPase subunit K 17 4 31 ------yqv-rlbcefghsnujx--w AtpH [C] COG0712 F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) 17 4 30 ------yqv-rlbcefghsnujx--w AtpC [C] COG0355 F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) 17 4 32 ------yqv-rlbcefghsnujx--w AtpG [C] COG0224 F0F1-type ATP synthase gamma subunit 18 7 100 ao-p-zyq-dr-bcefghsnuj---- GlcD [C] COG0277 FAD/FMN-containing dehydrogenases 18 8 77 aomp-z-q-drlbcefgh-nuj---- GlpC [C] COG0247 Fe-S oxidoreductases 15 8 49 ao----yq-dr--cefgh-n-jxi-- Fdx [C] COG0633 Ferredoxin 16 8 59 aompk---vdr--cefg-s-ujx--- - [C] COG1146 Ferredoxin 3 19 5 36 aompkzyqvdr--cef--snujx--- NuoI [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) 17 7 31 -o---zy--dr-bcefghsnujxi-- FumC [C] COG0114 Fumarase 22 5 37 a-m---yqvdrlbcefghsnujxitw GpsA [C] COG0240 Glycerol 3-phosphate dehydrogenase 21 6 33 ao-pkzyqvdrlbcefghs--j--tw GlpK [C] COG0554 Glycerol kinase 15 9 30 -o-p--y--drlbcefghs--j--t- GlpA [C] COG0578 Glycerol-3-phosphate dehydrogenase 17 10 50 -o-pkzy-vdrlb-efgh---j--tw UgpQ [C] COG0584 Glycerophosphoryl diester phosphodiesterase 13 11 27 -o---zyq-dr-bcef--s--jx--- CyoC [C] COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 13 11 30 -o---zyq-dr-bcef--s--jx--- CyoB [C] COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 14 11 33 ao---zyq-dr-bcef--s--jx--- CyoA [C] COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 22 5 41 -ompkzyq-dr-bcefghsnujxi-w Ppa [C] COG0221 Inorganic pyrophosphatase 17 8 28 ao-p-zyqvdrlbcef-h--uj---- Icd [C] COG0538 Isocitrate dehydrogenases 20 6 44 aompkzy--drlbcefgh-n-jx-t- LldD [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases 16 11 57 ---pkzyq---lbcefgh-nuj--t- LdhA [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases 23 4 45 aomp-zyqvdrlbce-ghs-ujxitw Mdh [C] COG0039 Malate/lactate dehydrogenases 21 5 42 ao-pkzy-vdrlbcefghsnujx--- SfcA [C] COG0281 Malic enzyme 19 7 202 -omp-zyq-drlbcefgh-nuj---w PutA [C] COG1012 NAD-dependent aldehyde dehydrogenases 13 6 21 ------yqvdr--cef--snujx--- NuoG [C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) 14 10 54 ao-p--y-vdrlb-efg-s--j---- NemA [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family 18 6 26 ao-pkzyqvdr--cef--snujx--- NuoB [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 13 8 21 --m---yqvdr--cef--sn-jx--- NuoE [C] COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoC [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoD [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 15 8 24 ao-p-z-q-dr--cef--snujx--- NuoH [C] COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H) 14 9 22 -o-p-z-q-dr--cef--snujx--- NuoK [C] COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) 15 8 23 ao-p-z-q-dr--cef--snujx--- NuoN [C] COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N) 18 8 38 ao-pkz-q-dr-bcefg-snujx--- NuoL [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit 15 8 26 ao-p-z-q-dr--cef--snujx--- NuoJ [C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) 13 8 21 --m---yqvdr--cef--sn-jx--- NuoF [C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit 15 10 84 -o-p-zyq-drlb-efghs--j---- Qor [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases 16 10 39 -o--kz-q-dr-b-efg-s-ujxit- GltP [C] COG1301 Na+/H+-dicarboxylate symporters 19 6 37 ao----yqv-rlb-efgh-nujxitw IscU [C] COG0822 NifU homologs involved in Fe-S cluster formation 21 5 89 aompkz-qvdrlbcefghsnuj---- NfnB [C] COG0778 Nitroreductase 18 8 94 -o-p-zyqvdrlbcefg-s-uj--t- Tas [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) 11 12 18 a-m-k-yq--rlb--f----uj---- PycA [C] COG1038 Pyruvate carboxylase, C-terminal domain/subunit 18 8 63 aompkzyqv-rlbce-g---uj--t- PorA [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit 18 8 60 aompkzyqv-rlbce-g---uj--t- PorB [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit 17 9 55 aompkz-qv-rlbce-g---uj--t- PorG [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit 16 8 35 -o-p-zyq-dr-bc-fg-snujx--- QcrA [C] COG0723 Rieske Fe-S protein 21 6 41 aomp-zyq-dr-bcefghsnujxi-- FrdB [C] COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein 17 8 28 ao-p-zy--dr-b-efg-snujxi-- SdhC [C] COG2009 Succinate dehydrogenase/fumarate reductase cytochrome b subunit 23 4 54 aomp-zyqvdrlbcefghsnujxi-- SdhA [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunits 21 6 38 aomp-zyq-dr-bcefghsnujxi-- SucD [C] COG0074 Succinyl-CoA synthetase alpha subunit 21 6 34 aomp-zyq-dr-bcefghsnujxi-- SucC [C] COG0045 Succinyl-CoA synthetase beta subunit 14 8 35 -o-p-zy--drlbc-f-----jxi-w AcoA [C] COG1071 Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunit 14 8 33 -o-p-zy--drlbc-f-----jxi-w AcoB [C] COG0022 Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunit 12 10 20 ------yq-dr-bcefgh---j-i-- GlgB [G] COG0296 1,4-alpha-glucan branching enzyme 25 2 43 aompkzyqvdrlbcefghsnuj-itw Pgk [G] COG0126 3-phosphoglycerate kinase 16 6 35 ------yqvdrlbce-ghs--j-itw PfkA [G] COG0205 6-phosphofructokinase 13 9 23 ------y-v-rlbce-gh-n-j-it- Gnd [G] COG0362 6-phosphogluconate dehydrogenase, family 1 16 6 42 ------y-v-rlbcefghsnuj-it- NagB [G] COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase 15 11 95 ao--kz--vd-lb-efgh---j--tw MglA [G] COG1129 ABC-type sugar (aldose) transport system, ATPase component 18 9 110 -o-pkz--vdrlbcefghs--j--tw MalF [G] COG1175 ABC-type sugar transport systems, permease components 23 4 175 aompkz-qvdrlbcefghsnuj--tw MalK [G] COG1130 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component 23 4 48 aom-kzyqvdrlbcefghsnujx-t- SuhB [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family 16 6 41 ------y-vdrlbcefghsn-jx-t- BglX [G] COG1472 Beta-glucosidase-related glycosidases 25 2 51 aompkzyqvdrlbcefghsnuj-itw Eno [G] COG0148 Enolase 17 5 42 ------yqvdrlbcefgh-nuj--tw Fba [G] COG0191 Fructose/tagatose bisphosphate aldolase 11 11 29 ---p--y-vd-lb-e-gh-n-j---- GalM [G] COG2017 Galactose mutarotase and related enzymes 15 10 25 --m-k-yq-drlbcefgh---j-i-- GlgP [G] COG0058 Glucan phosphorylase 18 4 31 ------yqvdrlbcefghsnuj-it- Zwf [G] COG0364 Glucose-6-phosphate 1-dehydrogenase 23 4 41 -omp-zyqvdrlbcefghsnuj-itw Pgi [G] COG0166 Glucose-6-phosphate isomerase 25 2 61 aompkzyqvdrlbcefghsnuj-itw GapA [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase 15 12 36 a-m---y-vd-lbcef-hs--j--tw GlpF [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) 16 10 39 aom-k--qv-r-bcefg-snuj---- CpsB [G] COG0662 Mannose-6-phosphate isomerase 13 9 23 ------y-vdrlb-efghs--j--t- NagA [G] COG1820 N-acetylglucosamine-6-phosphate deacetylase 21 6 40 --mp--yqvdrlbcefghsnuj-itw Rpe [G] COG0036 Pentose-5-phosphate-3-epimerase 24 3 215 aompkzyqvd-lbcefghsnujxit- RhaT [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily 26 1 925 aompkzyqvdrlbcefghsnujxitw ProP [GEPR]COG0477 Permeases of the major facilitator superfamily 21 6 43 aompkz-qvdr-bcefg-snujx-t- PpsA [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase 15 8 75 ---p--yqvdrlbcefghs--j---- GpmB [G] COG0406 Phosphoglycerate mutase/fructose-2,6-bisphosphatase 26 1 94 aompkzyqvdrlbcefghsnujxitw CpsG [G] COG1109 Phosphomannomutase 11 9 20 a-----y-vdrlb-e-gh------t- ManA [G] COG1482 Phosphomannose isomerase 5 5 8 ----kzyqv----------------- - [G] COG2152 Predicted glycosylase 21 5 32 aompkzyqvdrlbcefg-snuj---- - [G] COG0063 Predicted sugar kinase 15 11 30 ao--kzyqv-rlb-ef----ujx--- NagD [G] COG0647 Predicted sugar phosphatases of the HAD superfamily 15 11 53 ---pk-y-vdrlbcefg-s-uj---- CDA1 [G] COG0726 Predicted xylanase/chitin deacetylase 23 4 53 -ompkzy-vdrlbcefghsnuj-itw PykF [G] COG0469 Pyruvate kinase 19 7 31 aompkzy--d-l-cefghsn-j-it- RpiA [G] COG0120 Ribose 5-phosphate isomerase 21 5 50 aompkzyqv-rlb-efghs-ujx--w AraD [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases 13 13 48 a----zy-v-rlbcef-h---j--t- XylB [G] COG1070 Sugar (pentulose and hexulose) kinases 19 7 112 aompkzy-vdrlbcefghs--j---- RbsK [G] COG0524 Sugar kinases, ribokinase family 18 9 111 -o-pkz--vdrlbcefghs--j--tw MalG [G] COG0395 Sugar permeases 17 10 83 -o-pkz--vdrlbcefghs--j--t- UgpB [G] COG1653 Sugar-binding periplasmic proteins/domains 18 9 40 --mp--yqvdrlbcefgh-nuj-i-- MipB [G] COG0176 Transaldolase 23 4 57 --mpkzyqvdrlbcefghsnuj-itw TktA [G] COG0021 Transketolase 25 2 45 aompkzyqvdrlbcefghsnuj-itw TpiA [G] COG0149 Triosephosphate isomerase 12 8 19 aompk-yq---lb-e----n---i-- AroD [E] COG0710 3-dehydroquinate dehydratase 13 8 21 ------y-vdr-bcefghs-uj---- AroQ [E] COG0757 3-dehydroquinate dehydratase II 19 8 32 ---pkzy-vdrlbcefghsnuj-i-- AroB [E] COG0337 3-dehydroquinate synthetase 20 6 36 aom-k-yqvdrlbcefghsnuj---- LeuC [E] COG0065 3-isopropylmalate dehydratase large subunit 19 7 35 a-m-k-yqvdrlbcefghsnuj---- LeuD [E] COG0066 3-isopropylmalate dehydratase small subunit 18 8 30 ---pkzyqvd-lbcefghsnuj---- MetF [E] COG0685 5,10-methylenetetrahydrofolate reductase 23 4 39 aompkzyqvdrlbcefghsnuj-i-- AroA [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase 12 14 40 aom--z--vd--bcef----uj---- LivK [E] COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component 19 7 91 ao-pkz-qvd-lb-efgh--uj-itw OppF [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 19 7 87 ao-pkz-qvd-lb-efgh--uj-itw DppD [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 21 6 173 ao-pkz-qvdrlbcefgh--uj-itw OppA [EP] COG0747 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components 21 6 125 ao-pkz-qvdrlbcefgh--uj-itw DppB [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 21 6 124 ao-pkz-qvdrlbcefgh--uj-itw DppC [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 15 10 51 ao---z--vd-l--efgh-nuj--tw PotB [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I 15 10 51 ao---z--vd-l--efgh-nuj--tw PotC [E] COG1177 ABC-type spermidine/putrescine transport system, permease component II 19 7 29 aom---yqvdrlbcefghsnuj---- HisG [E] COG0040 ATP phosphoribosyltransferase (histidine biosynthesis) 20 6 37 a-m-kzyqvdrlbcefghsnuj---- IlvH [E] COG0440 Acetolactate synthase, small subunit 20 6 38 a-m-kzyqvdrlbcefghsnuj---- ArgB [E] COG0548 Acetylglutamate kinase 20 6 30 a-m-kzyqvdrlbcefghsnuj---- ArgC [E] COG0002 Acetylglutamate semialdehyde dehydrogenase 22 5 108 a-mpkzyqvdrlb-efghsnujxi-- ArgE [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases 19 7 170 aomp-zy---rlbcefghs--jxi-w PotE [E] COG0531 Amino acid transporters 22 4 41 aompkzyqvdrlbcefghsnuj---- TrpD [E] COG0547 Anthranilate phosphoribosyltransferase 22 4 69 aompkzyqvdrlbcefghsnuj---- TrpE [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I 22 4 51 aompkzyqvdrlbcefghsnuj---- PabA [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II 20 6 31 aomp--yqvdrlbcefghsnuj---- ArgH [E] COG0165 Argininosuccinate lyase 20 6 30 aomp--yqvdrlbcefghsnuj---- ArgG [E] COG0137 Argininosuccinate synthase 24 3 44 aompkzyqvdrlbcefghsnujxi-- Asd [E] COG0136 Aspartate-semialdehyde dehydrogenase 24 3 56 aompkzyqvdrlbcefghsnujxi-- LysC [E] COG0527 Aspartokinases 20 6 66 aom---yqvdrlbcefghsnujx--- IlvE [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase 20 6 41 aomp--yqvdrlbcefghsnuj---- CarB [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) 20 6 36 aomp--yqvdrlbcefghsnuj---- CarA [EF] COG0505 Carbamoylphosphate synthase small subunit 20 6 43 aomp-zyqvdrlb-efghsnuj---- PheA [E] COG1605 Chorismate mutase 23 4 38 aompkzyqvdrlbcefghsnuj-i-- AroC [E] COG0082 Chorismate synthase 19 7 72 -o-pkzy-vdrlbcefghsnuj---- MetC [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases 20 5 52 ao----yqvdrlbcefgh-nujxit- NifS [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes 20 6 63 -o-pkzyqvdrlbcefghsnuj---- CysK [E] COG0031 Cysteine synthase 19 7 45 a-mp--yqvdrlbcefghsnuj---- LysA [E] COG0019 Diaminopimelate decarboxylase 22 5 57 aompkz-qv-rlbcefghsnujxi-- DapA [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase 20 6 49 a-m-kzyqvdrlbcefghsnuj---- IlvD [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase 13 13 35 -o-pkzy-vd--bc-f-hs--j---- DAP2 [E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases 17 5 26 ------yqvdrlbcefghsnuj--t- ProA [E] COG0014 Gamma-glutamyl phosphate reductase 17 5 28 ------yqvdrlbcefghsnuj--t- ProB [E] COG0263 Glutamate 5-kinase 17 10 44 ao-pkzy-vd--bcef-h-nuj-i-- GdhA [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase 16 10 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0067 Glutamate synthase domain 1 16 10 30 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0069 Glutamate synthase domain 2 16 10 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0070 Glutamate synthase domain 3 19 7 30 aom---yqvdrlbcefghsnuj---- HisH [E] COG0118 Glutamine amidotransferase 23 3 64 aompkzyqvdrlbcefghsnujx--- GlnA [E] COG0174 Glutamine synthase 19 8 34 -o-pkzyqvdrlbcefg-sn-j-i-- GcvH [E] COG0509 Glycine cleavage system H protein (lipoate-binding) 16 10 48 -o-pkzyqvdr-bcef--sn-j---- GcvT [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase) 16 10 25 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain 16 10 24 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain 26 1 53 aompkzyqvdrlbcefghsnujxitw GlyA [E] COG0112 Glycine hydroxymethyltransferase 21 6 120 ao-pkzyq--rlbcefghsnuj-it- DadA [E] COG0665 Glycine/D-amino acid oxidases (deaminating) 19 7 31 aom---yqvdrlbcefghsnuj---- HisD [E] COG0141 Histidinol dehydrogenase 13 9 24 a-mpk-yqvdrlb-e-g--------- HIS2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family 22 4 54 aompkzyqvdrlbcefghsnuj---- HisC [E] COG0079 Histidinol-phosphate aminotransferase/Tyrosine aminotransferase 22 4 43 aompkzyqvdrlbcefghsnuj---- ThrA [E] COG0460 Homoserine dehydrogenase 19 7 30 -ompkzyqvdrlbce-ghs-uj---- ThrB [E] COG0083 Homoserine kinase 19 7 28 aom---yqvdrlbcefghsnuj---- HisB [E] COG0131 Imidazoleglycerol-phosphate dehydratase 19 7 30 aom---yqvdrlbcefghsnuj---- HisF [E] COG0107 Imidazoleglycerol-phosphate synthase 22 4 34 aompkzyqvdrlbcefghsnuj---- TrpC [E] COG0134 Indole-3-glycerol phosphate synthase 20 6 46 a-m-k-yqvdrlbcefghsnujx--- LeuB [E] COG0473 Isocitrate/isopropylmalate dehydrogenase 19 7 58 a-mpk-yqvdr-bcefghsnuj---- LeuA [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases 19 7 31 a-m-k-yqvdrlbcefghsnuj---- IlvC [EH] COG0059 Ketol-acid reductoisomerase 20 7 40 a-mpkzyqv-rlb-efghsnuj-i-- MetE [E] COG0620 Methionine synthase II (cobalamin-independent) 11 10 22 a-mp-zyq--r-bc------uj---- HyuA [E] COG0145 N-methylhydaintoinase A 9 10 17 --mp-zyq--r--c------uj---- HyuB [E] COG0146 N-methylhydaintoinase B 19 8 48 ---pkzyqvdrlbcefg-s-ujx-t- GltD [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases 22 5 79 aompkzyq-d--bcefghsnujxit- PutP [EHR] COG0591 Na+/proline, Na+/panthothenate symporters and related permeases 11 11 12 -o----y-vdrlb--f-h--uj---- MET17 [E] COG2873 O-acetylhomoserine sulfhydrylase 24 3 42 aompkzyqvdrlbcefghsnuj--tw ArgF [E] COG0078 Ornithine carbamoyltransferase 22 4 87 aompkzyqvdrlbcefghsnuj---- ArgD [E] COG0160 PLP-dependent aminotransferases 25 2 123 aompkzyqvdrlbcefghsnujxit- AvtA [E] COG0436 PLP-dependent aminotransferases 21 5 61 aompkzyqvdrlbcefghs-uj---- SerA [E] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases 19 7 28 aom---yqvdrlbcefghsnuj---- HisI [E] COG0139 Phosphoribosyl-AMP cyclohydrolase 18 6 27 -om---yqvdrlbcefghsnuj---- HisI [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase 22 5 33 aompkzyqvd-lbcefghsnuj-i-- TrpF [E] COG0135 Phosphoribosylanthranilate isomerase 19 7 28 aom---yqvdrlbcefghsnuj---- HisA [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 20 6 31 aomp--yqvdrlbcefghsnuj---- PheA [E] COG0077 Prephenate dehydratase 21 5 32 aomp-zyqvdrlbcefghsnuj---- TyrA [E] COG0287 Prephenate dehydrogenase 20 7 37 --mp-zyqvdrlbcefghsnuj--t- ProC [E] COG0345 Pyrroline-5-carboxylate reductase 21 5 54 -om-kzy-vdrlbcefghs-uj-itw CsdB [E] COG0520 Selenocysteine lyase 17 8 30 aompkzyqvd-lbc-fg---uj---- - [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase 23 4 45 aompkzyqvdrlbcefghsnuj-i-- AroE [E] COG0169 Shikimate 5-dehydrogenase 17 5 33 ------yqvdrlbcefghsnuj-i-- AroK [E] COG0703 Shikimate kinase 17 9 33 a-mpkzyqvdr-b-ef--snuj---- SpeE [E] COG0421 Spermidine synthase 14 12 69 ao---z--vd-l-cefgh-n-j--t- PotD [E] COG0687 Spermidine/putrescine-binding periplasmic protein 21 5 103 a-mpkzyqvdrlbcefghsnuj---- IlvB [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] 19 6 47 -o-p-zy-vdrlbcefghsnujx--- IlvA [E] COG1171 Threonine dehydratase 19 7 88 ao-pkzy-vdrlb-efghsn-j---w Tdh [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 22 4 48 aompkzyqvdrlbcefghsnuj---- ThrC [E] COG0498 Threonine synthase 23 4 35 aompkzyqvdrlbcefghsnuj-i-- TrpA [E] COG0159 Tryptophan synthase alpha chain 21 6 32 aom-k-yqvdrlbcefghsnuj-i-- TrpB [E] COG0133 Tryptophan synthase beta chain 26 1 84 aompkzyqvdrlbcefghsnujxitw PepP [E] COG0006 Xaa-Pro aminopeptidase 16 10 41 aom---yqvd-lbce-gh--uj--t- UshA [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases 19 5 29 ao-p--yqvdrlbcefghsnuj---- PurH [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 20 6 55 -om-kzy-vdrlbcefgh-nuj--tw Apt [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins 23 4 57 ao--k-yqvdrlbcefghsnujxitw Adk [F] COG0563 Adenylate kinase and related kinases 21 5 42 aompk-yqvdrlbcefghsnuj---- PurB [F] COG0015 Adenylosuccinate lyase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurA [F] COG0104 Adenylosuccinate synthase 21 5 34 aompkzyqvdrlbcefg-snuj---- PyrB [F] COG0540 Aspartate carbamoyltransferase, catalytic chain 26 1 44 aompkzyqvdrlbcefghsnujxitw PyrG [F] COG0504 CTP synthase (UTP-ammonia lyase) 14 9 22 -o---zy-vdrlb-e-gh---j--tw Cdd [F] COG0295 Cytidine deaminase 18 8 53 aompkzyqvd--bcef-hs-uj---- SsnA [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases 16 6 36 ------yq-drlbcefghsn-jxi-- - [FJ] COG0590 Cytosine/adenosine deaminases 19 8 35 aompkz-q--r-bcef-hsnujxi-- Dcd [F] COG0717 Deoxycytidine deaminase 10 10 16 a--pk-y-vd-lb---g-------t- ComEB [F] COG2131 Deoxycytidylate deaminase 17 8 25 -omp-z-qvdrlbce-gh---j--tw DeoC [F] COG0274 Deoxyribose-phosphate aldolase 25 2 74 aompkzyq-drlbcefghsnujxitw Hit [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases 19 7 44 aompkzyqvdrlbcef--s-uj---- PyrC [F] COG0044 Dihydroorotase 22 4 42 aompkzyqvdrlbcefghsnuj---- PyrD [F] COG0167 Dihydroorotate dehydrogenase 16 5 31 ------yqvdr-bcefghsnujx--- GppA [FP] COG0248 Exopolyphosphatase 18 6 29 -o-p--yqvdrlbcefghsnuj---- PurN [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN 24 3 52 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0518 GMP synthase - Glutamine amidotransferase domain 24 3 37 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0519 GMP synthase - PP-ATPase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurF [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase 19 3 39 ------yqvdrlbcefghsnujxi-w Gmk [F] COG0194 Guanylate kinase 23 4 90 -ompkzyqvdrlbcefghsnuj-it- GuaB [F] COG0516 IMP dehydrogenase/GMP reductase 23 4 38 aompkzyq-dr-bcefghsnujxit- Ndk [F] COG0105 Nucleoside diphosphate kinase 23 4 40 aompkzyqvdrlbcefghsnuj-i-- PyrE [F] COG0461 Orotate phosphoribosyltransferase 22 4 36 aompkzyqvdrlbcefghsnuj---- PyrF [F] COG0284 Orotidine-5'-phosphate decarboxylase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurD [F] COG0151 Phosphoribosylamine-glycine ligase 21 5 33 aompk-yqvdrlbcefghsnuj---- PurM [F] COG0150 Phosphoribosylaminoimidazol (AIR) synthetase 17 7 26 -o-p--yqvdrlbcefghsn-j---- PurK [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 22 4 35 aompk-yqvdrlbcefghsnujx--- PurC [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase 21 5 32 aompk-yqvdrlbcefghsnuj---- PurE [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase 14 7 19 aompk--qvdrlbc------uj---- PurS [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain 24 3 52 aompkzyqvdrlbcefghsnuj--tw PrsA [FE] COG0462 Phosphoribosylpyrophosphate synthetase 12 8 19 -o-pkz-qv-r--c------u-xit- THY1 [F] COG1351 Predicted alternative thymidylate synthase 16 10 31 a-mpkzyqv-rlbcef--s--j---- Pnp [F] COG0005 Purine nucleoside phosphorylase 26 1 60 aompkzyqvdrlbcefghsnujxitw NrdA [F] COG0209 Ribonucleotide reductase alpha subunit 20 3 41 -o----yq-drlbcefghsnujxitw NrdF [F] COG0208 Ribonucleotide reductase beta subunit 12 10 18 -o-p----vd-lb-e-gh---j--tw Tdk [F] COG1435 Thymidine kinase 26 1 48 aompkzyqvdrlbcefghsnujxitw Tmk [F] COG0125 Thymidylate kinase 21 5 32 -om-kzyqvdrlbcefgh-nuj--tw Upp [F] COG0035 Uracil phosphoribosyltransferase 13 6 26 -o----y-vd-lbce-gh-----itw Udk [F] COG0572 Uridine kinase 25 2 42 aompkz-qvdrlbcefghsnujxitw PyrH [F] COG0528 Uridylate kinase 24 3 38 aompkzyqvdrlbcefghsnuj-it- - [F] COG0127 Xanthosine triphosphate pyrophosphatase 15 7 30 ------yq--rlb-ef-hsnujxit- Dut [F] COG0756 dUTPase 15 11 42 a-mpk-yqv-rlb-efg--n----t- UbiB [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibB [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 19 8 30 a-mpkzyq-d--bcefgh-nujxi-- UbiX [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase 19 8 34 a-mpkzyq-d--bcefgh-nujxi-- UbiD [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases 21 6 42 aompkzyq-d--bcefghsnujxi-- UbiA [H] COG0382 4-hydroxybenzoate polyprenyltransferase 22 3 42 -o-p--yqvdrlbcefghsnujxitw FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase 22 4 35 -om--zyq-drlbcefghsnujxitw - [H] COG0212 5-formyltetrahydrofolate cyclo-ligase 18 8 33 aompk--qv---bcefghsnujx--- - [H] COG0720 6-pyruvoyl-tetrahydropterin synthase 17 5 33 ------yqvdrlbcefghsnuj-i-- FolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 19 8 53 --mpk-yq-dr-bcefghsnujxi-- BioF [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes 15 9 51 --m---yq-dr-b-efghsnuj-i-- BioA [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 16 8 34 --m---yqv-r-bcefghsnuj-i-- BioB [H] COG0502 Biotin synthase and related enzymes 23 4 38 aom-k-yqvdrlbcefghsnujxit- BirA [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase 21 6 32 aomp-zyq-dr-bcefghsnujxi-- HemB [H] COG0113 Delta-aminolevulinic acid dehydratase 26 1 45 aompkzyqvdrlbcefghsnujxitw CoaE [H] COG0237 Dephospho-CoA kinase 15 9 32 --m---yq--r-bcefghsnuj-i-- BioD [H] COG0132 Dethiobiotin synthetase 15 7 40 ------y-vdrlb-efghsn-j-i-w FolA [H] COG0262 Dihydrofolate reductase 23 4 44 aompkzyqvdrlbcefghsnuj-i-- FolP [H] COG0294 Dihydropteroate synthase 20 6 55 aompkzyq-dr-bcefghsnuj---- ThiF [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 19 3 34 ------yqvdrlbcefghsnuj-itw RibF [H] COG0196 FAD synthase 20 5 38 -o-p--yqvdrlbcefghsnujx-t- FolC [H] COG0285 Folylpolyglutamate synthase 15 6 26 ------yq-drlbcefghs-ujx--- FolE [H] COG0302 GTP cyclohydrolase I 19 6 41 a--p--yqvdrlbcefghsnuj-i-- RibA [H] COG0807 GTP cyclohydrolase II 25 2 78 aompkzyqvdrlbcefghsnujxit- IspA [H] COG0142 Geranylgeranyl pyrophosphate synthase 19 8 35 aomp-z-q-dr-bcefghsnuj-i-- AlsD [H] COG0001 Glutamate-1-semialdehyde aminotransferase 18 8 27 aomp-z-q-dr-bcefghsnu--i-- HemA [H] COG0373 Glutamyl-tRNA reductase 22 5 39 aompkzyqvdrlb-efghsnuj--t- ThiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 17 8 30 -o--kzyqvdr-bcefg-snuj---- PanB [H] COG0413 Ketopantoate hydroxymethyltransferase 17 8 27 -o---zyq-dr-bcefghsn-jxi-- LipA [H] COG0320 Lipoate synthase 15 9 42 -o-pkzyqv--lbcefg------i-w LplA [H] COG0095 Lipoate-protein ligase A 18 6 28 ---p--yqvdr-bcefghsnujxi-- UbiE [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaA [H] COG2896 Molybdenum cofactor biosynthesis enzyme 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaC [H] COG0315 Molybdenum cofactor biosynthesis enzyme 17 9 42 aompkz-q-dr-bcefgh--uj---- MoeA [H] COG0303 Molybdopterin biosynthesis enzyme 16 10 30 aompkz-q-dr-b-efgh--uj---- MoaB [H] COG0521 Molybdopterin biosynthesis enzymes 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaE [H] COG0314 Molybdopterin converting factor, large subunit 15 11 33 ao-pk--q-dr-bcefgh--uj---- MoaD [H] COG1977 Molybdopterin converting factor, small subunit 18 8 29 aompkz-q-dr-bcefgh-nuj---- MobA [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A 23 4 41 aompkzyqvdrlbcefg-snuj--tw NadE [H] COG0171 NAD synthase 16 10 36 a---kzyqvdrlb-efgh--uj---- SIR2 [H] COG0846 NAD-dependent protein deacetylases, SIR2 family 19 7 32 aom-k-yqv-rlbcefghsnuj---- NadC [H] COG0157 Nicotinate-nucleotide pyrophosphorylase 16 6 32 ------yqv-rlbcefg-snuj--tw NadD [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase 23 4 37 ao-pkzyqvdrlbcefghsnuj--tw PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase 14 7 24 ------yqvdr-bcefg-snuj---- PanC [H] COG0414 Panthothenate synthetase 23 4 45 aompkzyqvdrlbcefghsnuj--t- Dfp [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase 15 10 25 ao-p-zyq-dr-bcef--s--jx--- CyoE [H] COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor) 21 6 33 aomp-zyq-dr-bcefghsnujxi-- HemC [H] COG0181 Porphobilinogen deaminase 18 6 29 ---p--yq-drlbcefghsnujxi-- HemH [H] COG0276 Protoheme ferro-lyase (ferrochelatase) 10 11 15 ao--k-yq-dr-b--------j-i-- HemY [H] COG1232 Protoporphyrinogen oxidase 17 5 28 ------yqvdrlbcefghsnuj-i-- RibD [H] COG0117 Pyrimidine deaminase 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibD [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis 16 10 25 aom-k--qv-r-bcefg-snuj---- NadA [H] COG0379 Quinolinate synthase 18 5 29 -o----yqvdrlbcefghsnuj-i-- RibC [H] COG0307 Riboflavin synthase alpha chain 21 6 34 aom--zyqvdrlbcefghsnuj-i-- RibH [H] COG0054 Riboflavin synthase beta-chain 14 6 21 aompkzyqv-r--c-f--s--j---- SAM1 [H] COG0499 S-adenosylhomocysteine hydrolase 18 4 34 ------yqvdrlbcefghsnuj--tw MetK [H] COG0192 S-adenosylmethionine synthetase 17 9 24 aompk--q-dr-bcefg-snuj---- ThiS [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis 15 9 42 aomp-z-qvdr-bce-g---u--i-- ThiH [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes 17 9 24 aom-k--qvdr-bcefg-snuj---- ThiC [H] COG0422 Thiamine biosynthesis protein ThiC 18 8 27 aompkz-q--r-bcefghsnuj---- ThiL [H] COG0611 Thiamine monophosphate kinase 18 8 36 a--pk-yq-drlbcefghsnuj---- ThiE [H] COG0352 Thiamine monophosphate synthase 8 8 11 ------y-vd-lb-------uj--t- THI80 [H] COG1564 Thiamine pyrophosphokinase 17 7 27 ---p--yq-dr-bcefghsnujxi-- HemE [H] COG0407 Uroporphyrinogen-III decarboxylase 17 9 39 aomp-zyq-dr-bcefg-sn-j---- CysG [H] COG0007 Uroporphyrinogen-III methylase 19 8 36 aomp--yq-dr-bcefghsnu-xi-- HemD [H] COG1587 Uroporphyrinogen-III synthase 18 4 41 ------yqvdrlbcefghsnujxi-- FabD [I] COG0331 (acyl-carrier-protein) S-malonyltransferase 20 2 81 ------yqvdrlbcefghsnujxitw PlsC [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase 17 9 41 --mp-zyq-drlbcefgh-nuj---- MmsB [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related proteins 18 4 59 ------yqvdrlbcefghsnujxi-- FabB [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase 20 6 120 aompkzy--drlbcefgh--ujx-t- PaaJ [I] COG0183 Acetyl-CoA acetyltransferases 21 6 58 ao--k-yqvdrlbcefghsnujxi-- AccA [I] COG0825 Acetyl-CoA carboxylase alpha subunit 20 7 56 ao--k--qvdrlbcefghsnujxi-- AccD [I] COG0777 Acetyl-CoA carboxylase beta subunit 20 2 59 ------yqvdrlbcefghsnujxitw AcpP [IQ] COG0236 Acyl carrier protein 14 10 34 -o-p-zy--d--b-efgh-nuj-i-- - [I] COG1607 Acyl-CoA hydrolase 21 5 165 aomp-zy--drlbcefghsnujxi-- CaiC [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 18 8 64 aomp-zyq-dr-bcefghs-uj---- Acs [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases 22 5 60 ao--k-yqvdrlbcefghsnujxit- AccB [I] COG0511 Biotin carboxyl carrier protein 21 6 70 aom---yq-drlbcefghsnujxit- AccC [I] COG0439 Biotin carboxylase 26 1 48 aompkzyqvdrlbcefghsnujxitw CdsA [I] COG0575 CDP-diglyceride synthetase 9 8 19 a-mpk-yq-----c--------x-t- SEC59 [I] COG0170 Dolichol kinase 16 9 151 ao-p-zyq-drlb-efg-s--jx--- CaiD [I] COG1024 Enoyl-CoA hydratase/carnithine racemase 15 10 60 a--p--y-vdrlbcefg-s--j--t- Aes [I] COG0657 Esterase/lipase 11 9 28 ao---zyq--r--c-fgh------t- FAA1 [I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming) 19 7 74 -om-k-yq-drlbcefghs-ujx-t- PgpB [I] COG0671 Membrane-associated phospholipid phosphatase 8 5 12 a-m-kzyqv-r--------------- INO1 [I] COG1260 Myo-inositol-1-phosphate synthase 25 2 71 aompkzyqv-rlbcefghsnujxitw PgsA [I] COG0558 Phosphatidylglycerophosphate synthase 17 9 31 aom---y--dr-b-efghsnujxi-- Psd [I] COG0688 Phosphatidylserine decarboxylase 14 10 24 aom---y---r-b--f--snujxit- PssA [I] COG1183 Phosphatidylserine synthase 18 7 62 a--p--y-v--lbcefghsnujxi-w Cls [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes 16 6 33 ------yqvdrlb-e-g--nujxitw AcpS [I] COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) 25 2 49 aompkzyqvdrlbcefghsnujxit- UppS [I] COG0020 Undecaprenyl pyrophosphate synthase 24 3 228 aompkzy-vdrlbcefghsnujx-tw CcmA [Q] COG1131 ABC-type multidrug transport system, ATPase component 21 4 204 -o--k-yqvdrlbcefghsnujxi-w MdlB [Q] COG1132 ABC-type multidrug/protein/lipid transport system, ATPase component 19 8 70 ao-pkzyqv-rlb-efg-snuj--t- PncA [Q] COG1335 Amidases related to nicotinamidase 23 4 481 ao-pkzyqvdrlbcefghsnujxi-- FabG [QR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 14 11 29 aompk-y-vdrlb--fg----j---- HutI [Q] COG1228 Imidazolonepropionase and related amidohydrolases 23 4 83 aom-kzyqvdrlbcefghsnuj--tw NorM [Q] COG0534 Na+-driven multidrug efflux pump 12 10 35 -o----yq--r-b-ef-hsnuj---- SufI [Q] COG2132 Putative multicopper oxidases 26 1 493 aompkzyqvdrlbcefghsnujxitw SmtA [QR] COG0500 SAM-dependent methyltransferases 15 11 54 ao-pk--q-drlb-efgh--uj---- PaaI [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism 20 6 129 aompkzy-vdrlbcefghs-uj---- - [R] COG0842 ABC-type multidrug transport system, permease component 12 9 33 ao-pkz--vd--bc-f--------tw NosY [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component 23 4 121 aom--z-qvdrlbcefghsnujxitw PhnL [R] COG1136 ABC-type transport systems, involved in lipoprotein release, ATPase components 21 6 104 aom----qvdrlbcefghsnujxit- - [R] COG0577 ABC-type transport systems, involved in lipoprotein release, permease components 23 3 65 aompkzyqvdrlbcefghsnuj---w RimI [R] COG0456 Acetyltransferases 18 8 60 -om-k-y-vdrlbcefgh-nuj-i-- WbbJ [R] COG0110 Acetyltransferases (the isoleucine patch superfamily) 25 2 212 aompkzyqvdrlbcefghsnujxit- - [R] COG0517 CBS domains 17 9 35 --mpk-yq-dr-bcefg-snujx--- PaaY [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 19 7 45 a-mpkzyqvdrlbcef-h-n-jx--- - [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family 13 8 30 a-----yqvdrlb--f--snuj---- - [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase 26 1 81 aompkzyqvdrlbcefghsnujxitw ARC1 [R] COG0073 EMAP domain 15 6 37 aom-kz-qvdrlbc--g-------tw - [R] COG0618 Exopolyphosphatase-related proteins 19 7 28 -om-kz-qvdrlbcefghsn-j-i-- HflX [R] COG2262 GTPases 11 10 16 aomp-z-q-dr-b--------j-i-- - [R] COG1331 Highly conserved protein containing a thioredoxin domain 16 11 50 ao--kzy-vdrlb-efg-s--j-i-- - [R] COG1073 Hydrolases of the alpha/beta superfamily 17 9 28 aompkz--vdrlbce---s--j-it- - [R] COG0396 Iron-regulated ABC transporter ATPase subunit SufC 16 9 55 aompk---vd-lb-efghsn-j---- RfbX [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 14 12 42 -o-pk---vdrlbcef-h--uj---- AbgB [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase 15 12 32 aompk--q---lbcef-----jxit- PhnP [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I 18 6 39 aompkzy-vdrlbce--h---j-it- ElaC [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 19 8 79 aompkzyqvdr-bcefg-s--j--t- - [R] COG0714 MoxR-like ATPases 12 11 34 aom-k--q----b---gh-nu--it- - [R] COG0733 Na+-dependent transporters of the SNF family 15 10 38 -om-k---vd-lb-efgh-nuj--t- - [R] COG2252 Permeases 18 9 31 aompk-yq--r-b-e-ghsnuj-i-w - [R] COG1881 Phospholipid-binding protein 17 9 39 aompkz-qvdrlbcef-h---j---- - [R] COG0433 Predicted ATPase 13 9 18 -o-pkzyqvd-lb-e-----uj---- - [R] COG1832 Predicted CoA-binding protein 15 7 53 aompkz-qvdrlbc-f-----j---- - [R] COG0535 Predicted Fe-S oxidoreductases 19 3 33 ------yqvd-lbcefghsnujxitw ThdF [R] COG0486 Predicted GTPase 20 2 35 ------yqvdrlbcefghsnujxitw Obg [R] COG0536 Predicted GTPase 26 1 49 aompkzyqvdrlbcefghsnujxitw - [R] COG0012 Predicted GTPase 12 10 34 --m-kzy-v--lbc--g--n----tw - [R] COG1161 Predicted GTPases 19 5 33 aom-k-yqv--lb-efghsnujx--w - [R] COG0218 Predicted GTPases 14 7 31 aompk--qvd-lb-e-----u---tw - [R] COG1418 Predicted HD superfamily hydrolase 19 8 35 a--pk-yqvdrlb-efghsnuj-i-- - [R] COG1611 Predicted Rossmann fold nucleotide-binding protein 20 2 34 ------yqvdrlbcefghsnujxitw - [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase 22 5 64 aom---yqvdrlbcefghsnujxit- - [R] COG0042 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family 20 6 41 aompkzy-vdrlbcefghs-uj---- - [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold 18 6 62 -----zyqvdrlbcefghs-ujx-t- PqqL [R] COG0612 Predicted Zn-dependent peptidases 21 6 79 aompkzyqvdr-bcefg-snuj--t- - [R] COG0388 Predicted amidohydrolase 17 9 29 a--pkzy-v-r-bcefg-snuj---w - [R] COG0579 Predicted dehydrogenase 16 10 103 --mpk-yqvd-lbcefgh--uj---- MviM [R] COG0673 Predicted dehydrogenases and related proteins 9 4 14 a-mpkzyqv------------j---- - [R] COG1355 Predicted dioxygenase 16 5 27 ------yqvdrlbcefghsnuj---- - [R] COG0325 Predicted enzyme with a TIM-barrel fold 16 6 41 ------yqv-rlbcefghsn-jx-t- RssA [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily 19 8 85 -ompk-yqvdrlb-efghsn-j--t- - [R] COG1011 Predicted hydrolases of the HAD superfamily 21 6 90 aompkzy-vdrlbce-gh-n-j-itw Cof [R] COG0561 Predicted hydrolases of the HAD superfamily 22 4 276 ao-p-zyq-drlbcefghsnujx-tw MhpC [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 14 12 33 aom-k--qv-r-bcef--s--j---w - [R] COG0392 Predicted integral membrane protein 24 3 48 aompkzyqv-rlbcefghsnujx-tw - [R] COG0061 Predicted kinase 13 11 18 a-m---yqvdrlbc-f---n-j---- ArgJ [R] COG1364 Predicted kinase related to thiamine pyrophosphokinase 17 9 51 aompkz--vdrlbce---s--j-it- - [R] COG0719 Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufB 14 10 28 aom-k--q-d----efg-snuj---w - [R] COG1451 Predicted metal-dependent hydrolase 17 9 48 -om-kz-qvdrlbcefg----j-it- - [R] COG1266 Predicted metal-dependent membrane protease 14 11 23 aom--z-qvd--bcefgh-n------ - [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family) 16 10 24 ao-pkzy-vdrlbce-g--n-j---- CinA [R] COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA 21 6 71 aom-k--qvdrlbcefghsnujx-t- PerM [R] COG0628 Predicted permease 21 5 93 aompkz-qvdrlbcefghsnuj---- - [R] COG0730 Predicted permeases 14 9 30 --m---yqv---bcefghs-ujx--- - [R] COG0679 Predicted permeases 16 8 55 ----k-y-vdrlbcefghsn-j-i-- - [R] COG0637 Predicted phosphatase/phosphohexomutase 21 6 53 aom-k-yq-drlbcefghsnuj--tw Gph [R] COG0546 Predicted phosphatases 15 9 30 aom-kzy-v-rlb-efg-------tw - [R] COG0622 Predicted phosphoesterase 14 9 31 a-m-kzyq--r--cefgh---j-i-- Icc [R] COG1409 Predicted phosphohydrolases 18 9 43 -omp-z-q-dr-bcefghsnuj--t- FcbC [R] COG0824 Predicted thioesterase 13 8 29 ------yq-dr-bcefg-snuj---- - [R] COG0523 Putative GTPases (G3E family) 21 6 77 aompkzyq-dr-bcefghs-uj--tw ThiJ [R] COG0693 Putative intracellular protease/amidase 19 6 30 aom--zyqvd---cefghsnuj-it- SurE [R] COG0496 Survival protein, predicted acid phosphatase 23 4 321 aompk-yqvd-lbcefghsnujxit- NrfG [R] COG0457 TPR-repeat-containing proteins 12 10 48 ao--kz--vd-lb--f-----j--tw - [R] COG1079 Uncharacterized ABC-type transport system, permease component 13 9 19 aom-k---vd-lbc-------jxit- BioY [R] COG1268 Uncharacterized ACR 21 2 82 -o----yqvdrlbcefghsnujxitw - [R] COG1253 Uncharacterized CBS domain-containing proteins 21 6 99 aompkzyqvdrlbcefgh---j--tw HcaD [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases 13 12 21 ao-p-z-q-dr-b-ef-h--uj---- - [R] COG2041 Uncharacterized enzymes, related to nitrate reductase 22 5 44 aompkzyqvdrlbcefghs-uj--t- GlpG [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) 17 5 30 -o----yqvdrlbcefg-snuj---w CinA [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) 13 9 25 -o---zyq-d--b--fg-snujx--- - [R] COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems 10 11 26 a--pk-y-v---b--f--s-uj---- - [R] COG1524 Uncharacterized proteins of the AP superfamily 22 4 157 aompkzyqvdrlbcefghsnuj---- GloB [R] COG0491 Zn-dependent hydrolases, including glyoxylases 16 8 27 aompkz-qvdr-bc--g--nuj---- SpoIVFB [R] COG1994 Zn-dependent proteases 13 13 40 ao---z--vd--bcefgh---j--t- - [S] COG1593 Integral membrane protein, possible transporter 18 6 29 aompkzyqvdr--cefg-s-uj---- - [S] COG0062 Uncharacterized ACR 18 7 28 aompk--qvdrlbc-f--sn-j--tw - [S] COG1354 Uncharacterized ACR 13 7 23 ------y-vd-lb-efgh-nu---tw - [S] COG1739 Uncharacterized ACR 18 7 38 aom-k-y--drlb-efgh-nu--itw - [S] COG0327 Uncharacterized ACR 14 7 51 ------yq-dr-bcefghsn-jx--- IscA [S] COG0316 Uncharacterized ACR 8 7 10 ao---z-qv-r--c---------i-- - [S] COG1259 Uncharacterized ACR 14 11 21 ao---z--vd--b-efgh-n-j-it- - [S] COG1738 Uncharacterized ACR 14 9 23 a-m-kzyqvdr-bcefg--------- - [S] COG0432 Uncharacterized ACR 9 2 13 aompkzyqv----------------- - [S] COG2078 Uncharacterized ACR 11 5 16 aompk-yqv-r-bc------------ - [S] COG0011 Uncharacterized ACR 14 8 22 aom---yqvdrlbce-gh-------- - [S] COG0391 Uncharacterized ACR 13 11 31 aom-k--q-d---c-fg--nuj--t- - [S] COG1432 Uncharacterized ACR 15 11 35 ao-pkz-qvdr-bc-fg----j--t- - [S] COG1721 Uncharacterized ACR 20 2 37 ------yqvdrlbcefghsnujxitw - [S] COG0217 Uncharacterized ACR 12 7 19 aom-k--q-d-lbc---------itw - [S] COG1624 Uncharacterized ACR 13 11 23 a--pkzyqvdrl--ef-----j---- - [S] COG2110 Uncharacterized ACR related to the C-terminal domain of histone macroH2A1 7 6 10 ------yqvd-lb-----------t- - [S] COG1774 Uncharacterized ACR, PSP1 homologs 12 9 23 -ompk--qv-rlbc------uj---- - [S] COG1917 Uncharacterized ACR, double-stranded beta-helix domain 15 11 35 a-mp--y-vdrlbc-f-hsn-j---- - [S] COG0599 Uncharacterized ACR, homolog of gamma-carboxymuconolactone decarboxylase subunit 15 12 34 aom-k---vdr-b-efg-s--jx-t- - [S] COG1520 Uncharacterized proteins of WD40-like repeat family LUCA2.0 Total number of events, gains and losses are 15756 5812 9944 Total inconsistency = 21568 956 COGs number of species/inconsistency (number of events)/number of genes 12 13 21 a-mpkz-qvd--b-ef-----j---- LigT [J] COG1514 2'-5' RNA ligase 23 4 59 aompkz-qvdr-bcefghsnujxit- MiaB [J] COG0621 2-methylthioadenine synthetase 18 8 99 -o-pk-y-vdrlb-efgh-nujx--w RimL [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw AlaS [J] COG0013 Alanyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw ArgS [J] COG0018 Arginyl-tRNA synthetase 20 5 73 aom--zyqvdrlbc-f---nujxitw GatA [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases 20 5 34 aom--zyqvdrlbc-f---nujxitw GatB [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) 19 6 30 aom--z-qvdrlbc-f---nujxitw GatC [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit 20 2 35 ------yqvdrlbcefghsnujxitw AspS [J] COG0173 Aspartyl-tRNA synthetase 17 8 43 aompkzy--d-lbce-ghs-----tw AsnS [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases 25 2 44 ao-pkzyqvdrlbcefghsnujxitw CysS [J] COG0215 Cysteinyl-tRNA synthetase 12 8 19 ------yqvdrlb-efgh-n------ Dtd [J] COG1490 D-Tyr-tRNAtyr deacylase 26 1 50 aompkzyqvdrlbcefghsnujxitw KsgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) 26 1 85 aompkzyqvdrlbcefghsnujxitw TufB [JE] COG0050 GTPases - translation elongation factors 26 1 75 aompkzyqvdrlbcefghsnujxitw GlnS [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases 11 6 20 aompkzy--dr-------------tw GRS1 [J] COG0423 Glycyl-tRNA synthetase, class II 26 1 58 aompkzyqvdrlbcefghsnujxitw HisS [J] COG0124 Histidyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw IleS [J] COG0060 Isoleucyl-tRNA synthetase 26 1 48 aompkzyqvdrlbcefghsnujxitw LeuS [J] COG0495 Leucyl-tRNA synthetase 17 4 37 ------yqvdrlbcefghsnu--i-w LysU [J] COG1190 Lysyl-tRNA synthetase class II 26 1 55 aompkzyqvdrlbcefghsnujxitw Map [J] COG0024 Methionine aminopeptidase 20 2 40 ------yqvdrlbcefghsnujxitw Fmt [J] COG0223 Methionyl-tRNA formyltransferase 26 1 48 aompkzyqvdrlbcefghsnujxitw MetG [J] COG0143 Methionyl-tRNA synthetase 14 7 28 aomp--y-------efghsn-jx-t- FtsJ [J] COG0293 Methyltransferase involved in cell division 8 3 12 aompkzyq------------------ TRM1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase 8 3 12 aompkzyq------------------ eRF1 [J] COG1503 Peptide chain release factor eRF1 20 2 37 ------yqvdrlbcefghsnujxitw Pth [J] COG0193 Peptidyl-tRNA hydrolase 26 1 46 aompkzyqvdrlbcefghsnujxitw PheS [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit 26 1 46 aompkzyqvdrlbcefghsnujxitw PheT [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit 10 3 15 aompkzyqv-r--------------- GCD14 [J] COG2519 Predicted SAM-dependent methyltransferase involved in tRNA-Met maturation 25 2 58 aompk-yqvdrlbcefghsnujxitw HemK [J] COG2890 Predicted rRNA or tRNA methylase 20 2 39 ------yqvdrlbcefghsnujxitw TrmU [J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain 26 1 47 aompkzyqvdrlbcefghsnujxitw ProS [J] COG0442 Prolyl-tRNA synthetase 20 2 36 ------yqvdrlbcefghsnujxitw PrfA [J] COG0216 Protein chain release factor A 19 3 41 ------yqvdrlbcefghsnujxit- PrfB [J] COG1186 Protein chain release factor B 26 1 45 aompkzyqvdrlbcefghsnujxitw TruB [J] COG0130 Pseudouridine synthase 25 2 46 aompk-yqvdrlbcefghsnujxitw TruA [J] COG0101 Pseudouridylate synthase (tRNA psi55) 20 2 101 ------yqvdrlbcefghsnujxitw RluA [J] COG0564 Pseudouridylate synthases, 23S RNA-specific 25 2 54 aompkzyqvdrlbcefghsn-jxitw SUA5 [J] COG0009 Putative translation factor (SUA5) 19 6 76 -o--kzyqvdrlbcefghsnuj---- TdcF [J] COG0251 Putative translation initiation inhibitor 23 4 38 aompkz-qvd-lbcefghsnujxit- Tgt [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase 18 8 31 a-mpkzyq-dr-b-efghsn-jx--- Rph [J] COG0689 RNase PH 17 9 35 -o--kz-qv-r-bcefghsn-jxi-- CafA [J] COG1530 Ribonucleases G and E 10 4 26 aompkzy-v--lb------------- RPL8A [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a) 26 1 47 aompkzyqvdrlbcefghsnujxitw RplA [J] COG0081 Ribosomal protein L1 26 1 49 aompkzyqvdrlbcefghsnujxitw RplJ [J] COG0244 Ribosomal protein L10 26 1 49 aompkzyqvdrlbcefghsnujxitw RplK [J] COG0080 Ribosomal protein L11 26 1 48 aompkzyqvdrlbcefghsnujxitw RplM [J] COG0102 Ribosomal protein L13 26 1 47 aompkzyqvdrlbcefghsnujxitw RplN [J] COG0093 Ribosomal protein L14 26 1 45 aompkzyqvdrlbcefghsnujxitw RplO [J] COG0200 Ribosomal protein L15 26 1 48 aompkzyqvdrlbcefghsnujxitw RplP [J] COG0197 Ribosomal protein L16/L10E 20 2 35 ------yqvdrlbcefghsnujxitw RplQ [J] COG0203 Ribosomal protein L17 26 1 44 aompkzyqvdrlbcefghsnujxitw RplR [J] COG0256 Ribosomal protein L18 20 2 35 ------yqvdrlbcefghsnujxitw RplS [J] COG0335 Ribosomal protein L19 26 1 45 aompkzyqvdrlbcefghsnujxitw RplB [J] COG0090 Ribosomal protein L2 26 1 48 aompkzyqvdrlbcefghsnujxitw RplV [J] COG0091 Ribosomal protein L22 26 1 43 aompkzyqvdrlbcefghsnujxitw RplW [J] COG0089 Ribosomal protein L23 26 1 44 aompkzyqvdrlbcefghsnujxitw RplX [J] COG0198 Ribosomal protein L24 20 2 35 ------yqvdrlbcefghsnujxitw RpmA [J] COG0211 Ribosomal protein L27 20 2 35 ------yqvdrlbcefghsnujxitw RpmB [J] COG0227 Ribosomal protein L28 26 1 44 aompkzyqvdrlbcefghsnujxitw RpmC [J] COG0255 Ribosomal protein L29 26 1 46 aompkzyqvdrlbcefghsnujxitw RplC [J] COG0087 Ribosomal protein L3 22 5 39 aompkzyqvdrlb-efghsn-jx-t- RpmD [J] COG1841 Ribosomal protein L30/L7E 19 3 33 ------yqvd-lbcefghsnujxitw RpmF [J] COG0333 Ribosomal protein L32 20 2 40 ------yqvdrlbcefghsnujxitw RpmG [J] COG0267 Ribosomal protein L33 20 2 34 ------yqvdrlbcefghsnujxitw RpmH [J] COG0230 Ribosomal protein L34 20 2 34 ------yqvdrlbcefghsnujxitw RpmI [J] COG0291 Ribosomal protein L35 20 2 39 ------yqvdrlbcefghsnujxitw RpmJ [J] COG0257 Ribosomal protein L36 26 1 47 aompkzyqvdrlbcefghsnujxitw RplD [J] COG0088 Ribosomal protein L4 26 1 47 aompkzyqvdrlbcefghsnujxitw RplE [J] COG0094 Ribosomal protein L5 26 1 47 aompkzyqvdrlbcefghsnujxitw RplF [J] COG0097 Ribosomal protein L6 20 2 36 ------yqvdrlbcefghsnujxitw RplL [J] COG0222 Ribosomal protein L7/L12 19 3 35 ------yqvdrlbcefghsnujxit- RpsA [J] COG0539 Ribosomal protein S1 5 7 10 ------y-vd-lb------------- VacB [J] COG1098 Ribosomal protein S1 domains 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsJ [J] COG0051 Ribosomal protein S10 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsK [J] COG0100 Ribosomal protein S11 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsL [J] COG0048 Ribosomal protein S12 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsM [J] COG0099 Ribosomal protein S13 26 1 50 aompkzyqvdrlbcefghsnujxitw RpsN [J] COG0199 Ribosomal protein S14 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsO [J] COG0184 Ribosomal protein S15P/S13E 20 2 35 ------yqvdrlbcefghsnujxitw RpsP [J] COG0228 Ribosomal protein S16 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsQ [J] COG0186 Ribosomal protein S17 20 2 36 ------yqvdrlbcefghsnujxitw RpsR [J] COG0238 Ribosomal protein S18 26 1 45 aompkzyqvdrlbcefghsnujxitw RpsS [J] COG0185 Ribosomal protein S19 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsB [J] COG0052 Ribosomal protein S2 26 1 44 aompkzyqvdrlbcefghsnujxitw RpsC [J] COG0092 Ribosomal protein S3 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsD [J] COG0522 Ribosomal protein S4 and related proteins 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsE [J] COG0098 Ribosomal protein S5 20 2 35 ------yqvdrlbcefghsnujxitw RpsF [J] COG0360 Ribosomal protein S6 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsG [J] COG0049 Ribosomal protein S7 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsH [J] COG0096 Ribosomal protein S8 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsI [J] COG0103 Ribosomal protein S9 20 2 36 ------yqvdrlbcefghsnujxitw Frr [J] COG0233 Ribosome recycling factor 17 7 45 ----k-yqv-rlbcefghsnuj-i-- TrmA [J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase 26 1 46 aompkzyqvdrlbcefghsnujxitw SerS [J] COG0172 Seryl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw ThrS [J] COG0441 Threonyl-tRNA synthetase 26 1 80 aompkzyqvdrlbcefghsnujxitw FusA [J] COG0480 Translation elongation and release factors (GTPases) 26 1 52 aompkzyqvdrlbcefghsnujxitw Efp [J] COG0231 Translation elongation factor P/translation initiation factor eIF-5A 26 1 49 aompkzyqvdrlbcefghsnujxitw InfB [J] COG0532 Translation initiation factor 2 (GTPase) 26 1 46 aompkzyqvdrlbcefghsnujxitw InfA [J] COG0361 Translation initiation factor IF-1 13 11 17 a-mpkzyqv---bc-f--s--j---- GCN3 [J] COG0182 Translation initiation factor eIF-2B alpha subunit 8 3 18 aompkzy-v----------------- GCD2 [J] COG1184 Translation initiation factor eIF-2B delta subunit 26 1 49 aompkzyqvdrlbcefghsnujxitw TrpS [J] COG0180 Tryptophanyl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw TyrS [J] COG0162 Tyrosyl-tRNA synthetase 26 1 45 aompkzyqvdrlbcefghsnujxitw ValS [J] COG0525 Valyl-tRNA synthetase 21 4 68 a-----yqvdrlbcefghsnujxitw SpoU [J] COG0566 rRNA methylases 21 6 54 aom-kzy-vdrlbcefghsnuj-i-- Sun [J] COG0144 tRNA and rRNA cytosine-C5-methylases 19 3 32 ------yqvdrlbcefghsnujxit- MiaA [J] COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase 19 3 50 ------yqvdrlbcefghsnujxit- PcnB [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase 15 7 66 -o-----qvdrlb-efghsn-jx--- CspC [K] COG1278 Cold shock proteins 26 1 46 aompkzyqvdrlbcefghsnujxitw RpoA [K] COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw RpoB [K] COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) 26 1 63 aompkzyqvdrlbcefghsnujxitw RpoC [K] COG0086 DNA-directed RNA polymerase beta' subunit/160 kD subunit (split gene in archaea and Syn) 24 3 38 aompkzyqvdrlbcefghsnujx-t- RpoZ [K] COG1758 DNA-directed RNA polymerase subunit K/omega 7 4 11 aompk-y-v----------------- ELP3 [K] COG1243 ELP3 component of the RNA polymerase II complex, consists of an N-terminal BioB/LipA-like domain and a C-terminal histone acetyltransferase domain (only BioB/LipA-like domain in Thermotoga) 19 4 48 -o----yqvd-lbcefghsnuj-itw VacB [K] COG0557 Exoribonucleases 24 3 309 aompkzyqvdrlbcefghsnuj-i-w WecD [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases 16 11 35 aompkz--vdrlb-e---s--j-it- TroR [K] COG1321 Mn-dependent transcriptional regulator 14 6 22 aompkzy-vd-lbc------u---t- - [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP 15 10 29 a--pk---vdrlbc-f--sn-j--tw - [K] COG1386 Predicted transcriptional regulator containing the HTH domain 21 5 148 aompkz-qvdrlbcefghsnuj---- ArsR [K] COG0640 Predicted transcriptional regulators 14 12 65 aompkz--vdrlb-e-g----j---- - [K] COG1695 Predicted transcriptional regulators 15 11 42 aomp---qv---bcefgh-nuj---- SirA [K] COG0425 Predicted transcriptional regulators 20 7 57 aom-kz-q-drlb-efg-snujxit- Spo0J [K] COG1475 Predicted transcriptional regulators 9 7 14 aom-kzyq------ef---------- RCL1 [K] COG0430 RNA phosphate cyclase 19 7 74 ao-pkzy-vdrlbcefghs----i-w HepA [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family 26 1 48 aompkzyqvdrlbcefghsnujxitw NusG [K] COG0250 Transcription antiterminator 25 2 47 aompkz-qvdrlbcefghsnujxitw NusA [K] COG0195 Transcription terminator 20 6 307 aom-k--qvdrlbcefghsnuj---w AcrR [K] COG1309 Transcriptional regulator 12 10 47 -o-----qvdr-b-efgh--uj---- IclR [K] COG1414 Transcriptional regulator 17 9 149 aompkz--vdrlb-efg-sn-j---- MarR [K] COG1846 Transcriptional regulators 16 10 73 ao-p-z-qvdrlbce-gh---j--t- NagC [K] COG1940 Transcriptional regulators 14 12 63 ---pkzy-vdrlb-efgh---j---- ARO8 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs 20 2 43 ------yqvdrlbcefghsnujxitw Rnc [K] COG0571 dsRNA-specific ribonuclease 15 10 25 aom-kzy--dr-bcefg-s--j---- AlkA [L] COG0122 3-Methyladenine DNA glycosylase 26 1 61 aompkzyqvdrlbcefghsnujxitw Exo [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 17 8 28 -om--z---drlb-efghsnuj-it- MutY [L] COG1194 A/G-specific DNA glycosylase 16 10 40 aompkzyq--r-b--fgh-nuj---- CDC9 [L] COG1793 ATP-dependent DNA ligase 15 6 26 ------y---rlb-efghsnujxit- RecB [L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) 16 7 31 --m---y--drlb-efghsnuj-it- RecD [L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member 16 8 21 aompkz-qvd-lbcefg-------t- SbcC [L] COG0419 ATPase involved in DNA repair 25 2 75 aompkzyqvdrlbcefghsnu-xitw HolB [L] COG0470 ATPase involved in DNA replication 23 2 63 ao-p--yqvdrlbcefghsnujxitw GyrA [L] COG0188 DNA gyrase (topoisomerase II) A subunit 23 2 62 ao-p--yqvdrlbcefghsnujxitw GyrB [L] COG0187 DNA gyrase (topoisomerase II) B subunit 18 5 34 -o----yqvd-lbcefghsn-jxit- MutL [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) 15 10 41 -ompk---vd-lb-e-ghsnuj---- - [L] COG0863 DNA modification methylase 12 10 32 ao-pkzy--drl--e-g-------t- SSL2 [L] COG1061 DNA or RNA helicases of superfamily II 19 3 31 ------yqvdrlbcefghsnujxit- PolA [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains 26 1 47 aompkzyqvdrlbcefghsnujxitw DnaN [L] COG0592 DNA polymerase III beta subunit 21 4 63 a--p--yqvdrlbcefghsnujxit- DnaQ [L] COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonucleases 6 11 8 --mp--yq-d--b------------- POL4 [L] COG1796 DNA polymerase IV (family X) 25 2 46 aompkz-qvdrlbcefghsnujxitw DnaG [L] COG0358 DNA primase (bacterial type) 18 6 27 aompkzyqvdrlbcefg-------t- SbcD [L] COG0420 DNA repair exonuclease 11 10 14 ao-pkz-qvd--b-e---s------- Nfi [L] COG1515 Deoxyinosine 3'endonuclease (endonuclease V) 14 9 27 -ompkzyqv-r-b-e-g------i-w Nfo [L] COG0648 Endonuclease IV 21 5 36 -om----qvdrlbcefghsnujxitw UvrA [L] COG0178 Excinuclease ATPase subunit 19 7 38 a-mp--y--drlbcefghsnujx-t- XthA [L] COG0708 Exonuclease III 21 5 35 -om----qvdrlbcefghsnujxitw UvrB [L] COG0556 Helicase subunit of the DNA excision repair complex 10 8 36 ------y--d----efghsn-j--t- HrpA [L] COG1643 HrpA-like helicases 25 2 219 aompkz-qvdrlbcefghsnujxitw XerC [L] COG0582 Integrase 10 8 64 --mpkzyq-dr-bc------------ - [L] COG1372 Inteins 22 5 47 aompkzyqv-rlb-efghsnuj-it- Ada [L] COG0350 Methylated DNA-protein cysteine methyltransferase 23 3 58 --m-kzyqvdrlbcefghsnujxitw TatD [L] COG0084 Mg-dependent DNase 12 11 24 -om-k-yq----b--f-h-nuj---w - [L] COG1525 Micrococcal nuclease (thermonuclease) homologs 11 8 17 -om-k--qvd-lbc------u---t- - [L] COG1193 MutS-like ATPases involved in mismatch repair, family 1 19 6 42 -o-p--yqvd-lbcefghsn-jxit- MutS [L] COG0249 MutS-like ATPases involved in mismatch repair, family 2 24 3 198 aomp-zyqvdrlbcefghsnujxit- MutT [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes 21 5 40 -om----qvdrlbcefghsnujxitw UvrC [L] COG0322 Nuclease subunit of the excinuclease complex 13 8 38 -o----y---rlbcefgh-n-j---w DinP [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair 25 2 47 aompkzyqvdrlbcefghsnujxit- Nth [L] COG0177 Predicted EndoIII-related endonuclease 12 11 56 -o-p----vd--b-efgh-nuj---- - [L] COG1943 Predicted transposase 13 11 88 -ompk--qvdr--ce---s-u---t- - [L] COG0675 Predicted transposases 17 9 36 -ompkzyq--rlb-efghsn-j---- DinG [L] COG1199 Rad3-related DNA helicases 26 1 62 aompkzyqvdrlbcefghsnujxitw RecA [L] COG0468 RecA/RadA recombinase 16 6 31 -o----y--dr-bcefghsnujx-t- RnhA [L] COG0328 Ribonuclease HI 25 2 39 aompkzyqvdrlbcefghsnujxit- RnhB [L] COG0164 Ribonuclease HII 20 2 50 ------yqvdrlbcefghsnujxitw Ssb [L] COG0629 Single-stranded DNA-binding protein 22 5 48 aompk--qvd-lbcefghsnujxit- RecJ [L] COG0608 Single-stranded DNA-specific exonuclease 9 8 17 a-mpk--q---lb-----------tw - [L] COG1658 Small primase-like proteins (Toprim domain) 23 4 78 -omp--yqvdrlbcefghsnujxitw UvrD [L] COG0210 Superfamily I DNA and RNA helicases 15 9 42 aompk-yqv-r--cef--s-u----w - [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits 21 6 165 a-mp--yq-drlbcefghsnujx-tw SrmB [LKJ] COG0513 Superfamily II DNA and RNA helicases 14 10 23 -----zy--d-lbcefghsn-j--t- RecQ [L] COG0514 Superfamily II DNA helicase 26 1 59 aompkzyqvdrlbcefghsnujxitw TopA [L] COG0550 Topoisomerase IA 10 13 29 -omp-----d--b-e----nuj--t- - [L] COG1002 Type II restriction enzyme, methylase subunits 15 6 26 ------y-vdrlb-efghsnuj---w - [L] COG2256 Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase 15 5 28 ------y--drlb-efghsnu--itw Ung [L] COG0692 Uracil DNA glycosylase 18 9 34 ao-pkz-qvdrl-c--gh-nujx-t- - [L] COG1573 Uracil-DNA glycosylase 18 6 40 aompk---v--lb-efghsnu--itw TopA [L] COG0551 Zn-finger domain associated with topoisomerase type I 20 7 92 -ompk--q-dr-bcefg-snujxitw Soj [D] COG1192 ATPases involved in chromosome partitioning 22 4 55 aompkzyqvdr-bcefghsnujx--- Mrp [D] COG0489 ATPases involved in chromosome partitioning 12 13 36 aom-k--qv-r-b--fg---u---t- - [D] COG0455 ATPases involved in chromosome partitioning 23 4 57 aompk--qvdrlbcefghsnujx-tw FtsZ [D] COG0206 Cell division GTPase 19 6 41 aompk-yqvdrlbc-f--sn-j--tw Smc [D] COG1196 Chromosome segregation ATPases 17 8 46 a-mp--yqv---b-efghs-ujxit- MreB [D] COG1077 HSP70 class molecular chaperones involved in cell morphogenesis 18 7 32 -om-k-yqvdr-bcefghsnuj---- CrcB [D] COG0239 Integral membrane protein possibly involved in chromosome condensation 19 3 34 ------yqvd-lbcefghsnujxitw GidA [D] COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division 18 6 36 ----k-yqvdr-bcefghsnujxi-- Maf [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation 26 1 79 aompkzyqvdrlbcefghsnujxitw MesJ [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control 16 9 36 a----z-q-dr-bcefghsnujx--- CcmC [O] COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component 17 4 34 ------yqvd--b-efghsnujxitw Lon [O] COG0466 ATP-dependent Lon protease, bacterial type 20 2 50 ------yqvdrlbcefghsnujxitw HflB [O] COG0465 ATP-dependent Zn proteases 19 3 32 ------yqvdrlbcefghsnujxit- ClpX [O] COG1219 ATP-dependent protease Clp, ATPase subunit 14 9 70 aompkzy--dr-bc-f----uj---- SpoVK [O] COG0464 ATPases of the AAA+ class 21 3 81 --m---yqvdrlbcefghsnujxitw ClpA [O] COG0542 ATPases with chaperone activity, ATP-binding subunit 26 1 80 aompkzyqvdrlbcefghsnujxitw GroL [O] COG0459 Chaperonin GroEL (HSP60 family) 20 2 38 ------yqvdrlbcefghsnujxitw GroS [O] COG0234 Co-chaperonin GroES (HSP10) 18 7 33 -om---y--drlbcefghsnuj--tw - [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase 15 9 22 a-m-kz-qvdrlbc---h--uj--t- CcdA [O] COG0785 Cytochrome c biogenesis protein 12 7 35 ------y--d---cefghsn-j-it- FkpA [O] COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 15 7 28 aompkz---d----efghsnu---t- SlpA [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 20 7 57 aom-k-y-vdrlbcefghsn-jx-t- GrxC [O] COG0695 Glutaredoxin and related proteins 24 3 82 aompkzyqvdrlbcefghsnujx-t- HflC [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs 26 1 47 aompkzyqvdrlbcefghsnujxitw QRI7 [O] COG0533 Metal-dependent proteases with possible chaperone activity 23 4 93 -omp--yqvdrlbcefghsnujxitw DnaK [O] COG0443 Molecular chaperone 19 7 52 aompkzyqvdr-bcefg-s--jx--- IbpA [O] COG0071 Molecular chaperone (small heat shock protein) 23 4 40 -omp--yqvdrlbcefghsnujxitw GrpE [O] COG0576 Molecular chaperone GrpE (heat shock protein) 13 8 24 ------y---r-bcefghs-ujx-t- HtpG [O] COG0326 Molecular chaperone, HSP90 family 23 4 115 -omp--yqvdrlbcefghsnujxitw DnaJ [O] COG0484 Molecular chaperones (contain C-terminal Zn finger domain) 18 8 37 aompk--q---lbcefghsnujx--- NrdG [O] COG0602 Organic radical activating enzymes 17 5 68 ------yqvd-lbcefghsnujx-t- SurA [O] COG0760 Parvulin-like peptidyl-prolyl isomerase 18 7 38 -om---y--drlbcefghsnuj--tw MsrA [O] COG0225 Peptide methionine sulfoxide reductase 17 8 58 -om---y--drlbcefghsnuj--t- PpiB [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family 24 3 54 aompkzyqvdrlbcefghs-ujxit- AhpC [O] COG0450 Peroxiredoxin 18 7 40 -o-p-zyqvdr-bcefghsnuj---- Bcp [O] COG1225 Peroxiredoxin 12 8 24 aompk---v---b-efgh------t- LonB [O] COG1067 Predicted ATP-dependent protease 7 4 12 aompk-yq------------------ GIM5 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding 20 7 72 aompkzyqv-r-b-efghs-ujx-t- HslV [O] COG0638 Proteasome protease subunit 13 8 27 aom-kz--v-----efg-snuj---- Pcm [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase 17 8 37 ao-----q-dr-bcefghsnujxi-- DsbG [O] COG1651 Protein-disulfide isomerase 17 7 68 ao---zyq-drlbc-fg-snuj---w AprE [O] COG1404 Subtilisin-like serine proteases 26 1 239 aompkzyqvdrlbcefghsnujxitw TrxA [OC] COG0526 Thiol-disulfide isomerase and thioredoxins 26 1 76 aompkzyqvdrlbcefghsnujxitw TrxB [O] COG0492 Thioredoxin reductase 14 10 29 ao----y-----bcefghs-ujxi-- - [O] COG0694 Thioredoxin-like proteins and domains 21 5 81 -om---yqvdrlbcefghsnujxit- DegQ [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain 12 10 17 -o---zyq-dr-bc-f--s--jx--- CtaA [O] COG1612 Uncharacterized protein required for cytochrome oxidase assembly 21 5 76 aompkzyq-drlbcefghsnuj---- HtpX [O] COG0501 Zn-dependent protease with chaperone function 13 11 64 ----kzy--drlbcef--s--jx--- AmpC [M] COG1680 Beta-lactamase class C and other penicillin binding proteins 9 10 31 ------yq-dr---efg---uj---- Cfa [M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases 10 4 17 aompkzyq---lb------------- TagD [MI] COG0615 Cytidylyltransferase 23 4 43 -ompkzyqvdrlbcefghsnuj-it- GlmS [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains 25 2 238 aompkzyqvdrlbcefghsnujx-tw WcaA [M] COG0463 Glycosyltransferases involved in cell wall biogenesis 12 14 40 a-mpk-yq---lbcef-----j---- - [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis 13 11 21 ao--k--qvd---cefg-s-uj---- CpsB [M] COG0836 Mannose-1-phosphate guanylyltransferase 22 5 162 aompk-yqvdrlbcefghsnuj--t- WcaG [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 19 8 56 aompkzyq-dr-bc-f-hsnuj--t- GCD1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylases involved in lipopolysaccharide biosynthesis/translation initiation factor eIF2B subunits 10 6 32 ------yq------efghsnuj---- TonB [M] COG0810 Periplasmic protein TonB, links inner and outer membranes 17 9 30 aom-k--q--rlbcefghs-ujx--- Ugd [M] COG1004 Predicted UDP-glucose 6-dehydrogenase 24 3 260 aompkzyqvdrlbcefghsnujx-t- RfaG [M] COG0438 Predicted glycosyltransferases 7 9 12 ------y----lb--f---nu---t- DltB [M] COG1696 Predicted membrane protein involved in D-alanine export 24 3 52 aompkz-qvdrlbcefghsnujxit- - [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1 13 9 54 -o----yq-d-lbcefghs--j---- - [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases 16 4 40 ------yqvd---cefghsnujxit- - [M] COG0729 Predicted outer membrane protein 17 8 29 a-m-kzyq----b-efghsnujxi-- GutQ [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation 22 5 80 aompkz-qvdrlbcefg-snujx-t- MscS [M] COG0668 Small-conductance mechanosensitive channel 13 9 28 -o------vd--bcefghsnuj---- WcaJ [M] COG2148 Sugar transferases involved in lipopolysaccharide synthesis 16 9 22 -om-k---vd-lbcefghsnu-x--- WecB [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 21 5 56 --m-k-yqvdrlbcefghsnujxit- Rfe [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase 15 8 30 --m---yq-d-lbcefgh-nuj---w GalE [M] COG1087 UDP-glucose 4-epimerase 18 8 26 aompkz-q-drlbcef--sn-jx--- RfbD [M] COG1091 dTDP-4-dehydrorhamnose reductase 17 8 29 a-mpkzy--drlbcef-hsn-j---- RfbB [M] COG1088 dTDP-D-glucose 4,6-dehydratase 17 9 32 aompkz--vdrlbcef--sn-j---- RfbA [M] COG1209 dTDP-glucose pyrophosphorylase 8 12 20 ao--k---v---b---g---u---t- CheC [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation 14 13 30 ao--k---vd--bcefg-s-uj--t- CheA [N] COG0643 Chemotaxis protein histidine kinase and related kinases 9 15 11 ao--k---v---b--fg----j--t- CheD [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins 12 13 23 ao--k---v---b-efg-s-uj--t- CheB [NT] COG2201 Chemotaxis response regulator CheB, consists of CheY-like receiver domain and a methylesterase (demethylase) domain 13 14 53 ao--k---v---bcefg-s-uj--t- CheW [N] COG0835 Chemotaxis signal transduction protein 9 13 39 -om---y--dr---ef----uj---- BetA [N] COG2303 Choline dehydrogenase and related flavoproteins 20 2 35 ------yqvdrlbcefghsnujxitw LepA [N] COG0481 Membrane GTPase LepA 14 13 207 ao--k---vd--bcefg-s-uj--t- Tar [N] COG0840 Methyl-accepting chemotaxis protein 11 14 26 ao--k---v---b-efg---uj--t- CheR [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins 23 4 56 aompkz-qvdr-bcefghsnujxit- SppA [NO] COG0616 Periplasmic serine proteases (ClpP class) 20 6 35 -om-k--qvdr-bcefghsnujxit- SecD [N] COG0342 Preprotein translocase subunit SecD 20 6 32 -om-k--qvdr-bcefghsnujxit- SecF [N] COG0341 Preprotein translocase subunit SecF 26 1 46 aompkzyqvdrlbcefghsnujxitw SecY [N] COG0201 Preprotein translocase subunit SecY 20 2 40 ------yqvdrlbcefghsnujxitw YidC [N] COG0706 Preprotein translocase subunit YidC 18 7 31 ao-p-z-q-dr-bcefghsnujx--- TatC [N] COG0805 Sec-independent protein secretion pathway component TatC 18 7 51 ao-p-z-q-dr-bcefghsnujx--- TatA [N] COG1826 Sec-independent protein secretion pathway components 25 2 68 aompkzyqvdrlbcefghsnujxit- LepB [N] COG0681 Signal peptidase I 19 7 33 aom-kz-qvd-lbcefghsnuj---- PppA [N] COG1989 Signal peptidase, cleaves prepilin-like proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw Ffh [N] COG0541 Signal recognition particle GTPase 26 1 46 aompkzyqvdrlbcefghsnujxitw FtsY [N] COG0552 Signal recognition particle GTPase 12 12 35 ao--kz--vd-lb--f-----j--tw Med [N] COG1744 Surface lipoprotein 13 7 23 ------yq--r--cefghs-ujxi-- CysQ [P] COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase 19 7 91 aompkz--vdrlbcefgh-nuj---- FecB [P] COG0614 ABC-type Fe3+-siderophores transport systems, periplasmic components 22 5 46 aom-kz-qvdrlbcefgh-nujxit- ZnuA [P] COG0803 ABC-type Mn/Zn transport system, periplasmic Mn/Zn-binding (lipo)protein (surface adhesin A) 21 6 41 aom-kz-qvd-lbcefgh-nujxit- ZnuC [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component 22 5 49 aom-kz-qvdrlbcefgh-nujxit- ZnuB [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components 19 7 70 aompk---vdrlbcefgh-nuj---w FepC [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components 19 7 103 aompkz--vd-lbcefgh-nuj---w BtuC [PH] COG0609 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components 16 7 51 aom-kz--vdrlbce-gh------tw CbiO [P] COG1122 ABC-type cobalt transport system, ATPase component 14 7 31 aom-kz--vdrlbce--h-------w CbiQ [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters 17 9 34 aompkz-q-dr-bcefgh--uj---- ModA [P] COG0725 ABC-type molybdate transport system, periplasmic component 12 14 49 a-mp----vd--bcef-hs--j---- TauB [P] COG1116 ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, ATPase components 12 13 62 a-----y-vd--bcefgh---j-i-- TauA [P] COG0715 ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components 13 14 50 a-mp----vd--bcef-hs--j-i-- TauC [P] COG0600 ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components 21 6 38 aom-kz-qvdrlbcefghs-uj--tw PstB [P] COG1117 ABC-type phosphate transport system, ATPase component 21 6 46 aom-kz-qvdrlbcefghs-uj--tw PstS [P] COG0226 ABC-type phosphate transport system, periplasmic component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstA [P] COG0581 ABC-type phosphate transport system, permease component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstC [P] COG0573 ABC-type phosphate transport system, permease component 19 7 55 aompkz-q-dr-bcefghsnuj---- CysU [P] COG0555 ABC-type sulfate/molybdate transport systems, permease components 9 10 13 a---kzyq-d--bc------u----- MET3 [P] COG2046 ATP sulfurylase 15 11 23 a---kzyq-dr-bcefg-s-uj---- CysC [P] COG0529 Adenylylsulfate kinase and related kinases 9 14 14 -o--k-y-vd--b-ef--s------- PhoA [P] COG1785 Alkaline phosphatase 17 9 38 a-mp--yqvdrlbcef--sn-j---w AmtB [P] COG0004 Ammonia permeases 10 13 12 a-m-k-y-v-r-bc---h-n------ ACR3 [P] COG0798 Arsenite efflux pump ACR3 and related permeases 10 8 23 -ompkzyq--r-bc------------ ArsA [P] COG0003 Arsenite transporting ATPase 14 9 25 aompk-yqv---bce-gh------t- ECM27 [P] COG0530 Ca2+/Na+ antiporter 16 8 36 -om---y--drlbcefghsnuj---- CynT [P] COG0288 Carbonic anhydrase 10 13 15 ao----y---r-bce-g-s--j---- KatG [P] COG0376 Catalase (peroxidase I) 24 3 89 aompkzyqvdrlbcefgh-nuj-itw ZntA [P] COG2217 Cation transport ATPases 12 14 62 --mp--yq--rlbcef-----j---w MgtA [P] COG0474 Cation transport ATPases 18 8 46 aompkzyq-drlbce-gh-n-j---- EriC [P] COG0038 Chloride channel protein EriC 15 8 28 ----k-yqvdrlb-ef-hsnuj---- CzcD [P] COG1230 Co/Zn/Cd efflux system component 16 8 30 ao-p-zyqvd-lbc-f-h-nu----w CopZ [P] COG2608 Copper chaperone 10 11 20 ------yq-dr-b-e-gh-n-j---- SodC [P] COG2032 Cu/Zn superoxide dismutase 17 8 50 -om-k-yq-d-lbcefghsnu--i-- CitT [P] COG0471 Di- and tricarboxylate transporters 20 6 52 a--p-z-qvdrlbcefghsnuj--tw Fur [P] COG0735 Fe2+/Zn2+ uptake regulation proteins 12 12 51 -o-p--y-vdr-bcef--s--j---- HcaA1 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases 14 12 21 a-m-k--qvd-l-cefg-s-uj---- FeoB [P] COG0370 Ferrous ion uptake system protein FeoB (predicted GTPase) 13 13 21 a----zy-v---bcef-h-nu-x-t- FTR1 [P] COG0672 High-affinity iron permease 20 6 46 aom-kz-qvdrlbcefgh-nu---tw TrkA [P] COG0569 K+ transport systems, NAD-binding component 22 5 60 a-mpkzyq-drlbcefghsnujx-t- KefB [P] COG0475 Kef-type K+ transport systems, membrane components 24 2 79 aompkzyqvdrlbcefghsnujx--w Kch [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component 18 8 47 a-m-k-yqvdrlbcefghs-uj---- CorA [P] COG0598 Mg2+ and Co2+ transporters 10 14 20 -om-k---vd--bc-fg-----x--- MnhC [P] COG1006 Multisubunit Na+/H+ antiporter 9 14 18 -om-k---vd--b--fg-----x--- MnhE [P] COG1863 Multisubunit Na+/H+ antiporter 10 14 26 -om-k---vd--bc-fg-----x--- MnhB [P] COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit 9 14 13 -om-k---vd--b--fg-----x--- MnhF [P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit 15 12 29 a--pkz--v-r-bcefg--nuj-i-- ArsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases 17 8 39 aompk-y--drlbcefghs--j---- NhaP [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters 11 15 19 a-m-k---vd--b--fgh---j-i-- - [P] COG1392 Phosphate transport regulator (distant homolog of PhoU) 20 7 50 aompkz-qvdrlbcefg-s--j--tw PhoU [P] COG0704 Phosphate uptake regulator 18 9 50 aompk-y-vdr-b-efgh-nuj-i-- PitA [P] COG0306 Phosphate/sulphate permeases 21 6 36 aom-kzyqvdrlbcefgh--ujx-t- MMT1 [P] COG0053 Predicted Co/Zn/Cd cation transporters 14 9 23 -om-kzyqvdr---ef---nu---t- - [P] COG0428 Predicted divalent heavy-metal cations transporter 13 13 17 a-m-k---vd-l-cefg-s-uj---- FeoA [P] COG1918 Protein, probably involved in Fe2+ transport 12 13 27 -om--zyq-dr-b-efg----j---- SseA [P] COG2897 Rhodanese-related sulfurtransferases 21 6 95 aomp--yq-drlbcefghsnujx-t- PspE [P] COG0607 Rhodanese-related sulfurtransferases 13 9 37 ------yq--rlbcefgh--uj-i-- SUL1 [P] COG0659 Sulfate permease and related transporters (MFS superfamily) 10 11 23 ------y-----bcefg-sn-j-i-- CysJ [P] COG0369 Sulfite reductase flavoprotein subunit 13 11 25 a-----yq-dr-bcefg-sn-j---- CysI [P] COG0155 Sulfite reductase hemoprotein beta-component 22 5 49 -omp-zyq-drlbcefghsnujxit- SodA [P] COG0605 Superoxide dismutase 20 6 37 aom-kzyqvd-lbcefgh-nu---tw TrkG [P] COG0168 Trk-type K+ transport systems, membrane components 12 12 15 a-mpkz-qvd----e---s---xi-- CutA [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations 20 7 334 aom-k-y-vdrlbcefghs-ujx-t- CheY [T] COG0784 CheY-like receiver domains 14 11 41 aom-kzyq-d--bc-fg--n-j---- AcuC [TQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein 20 6 79 aompkzy-vd-lbcefghsnuj---- ApaH [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases 7 8 30 ------y--dr-bc----s----i-- - [T] COG1716 FHA-domain-containing proteins 14 12 64 aom---yqvdr-bcefg----j---- FhlA [T] COG2203 GAF domain 13 9 20 -o-p--y-v--lb-efghsn-j---- - [T] COG1956 GAF domain-containing proteins 17 10 210 aom----qvdr-bcefg-s-uj-it- AtoS [T] COG2202 PAS/PAC domain 12 11 18 a----z-q--r--cefghs-uj---- SixA [T] COG2062 Phosphohistidine phosphatase SixA 14 9 43 ---p--yq-drlbc-f--s-uj-i-w PTC1 [T] COG0631 Protein serine/threonine phosphatases 18 8 42 aom---yq-drlbcefghsnuj---- Wzb [T] COG0394 Protein-tyrosine-phosphatase 11 4 46 aompkzyqv----c-------j---- RAD55 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction 22 5 549 aom---yqvdrlbcefghsnujxit- BaeS [T] COG0642 Sensory transduction histidine kinases 18 8 297 -o-p-zyq-drlbcefghs--j-i-w SPS1 [T] COG0515 Serine/threonine protein kinases 20 6 116 aompkzyq-drlbcefgh-n-jx--- UspA [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins 18 4 90 ------yqvdrlbcefghsnuj-it- Crp [T] COG0664 cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 11 11 20 aom-kz--vd-lb-----s--j---- NatB [C] COG1668 ABC-type Na+ efflux pump, permease component 16 9 30 -o-p-zyq-drlb-efg-sn-jx--- AcnA [C] COG1048 Aconitase A 15 11 25 a-mpkz--vd-lb-efgh---j--t- AcyP [C] COG1254 Acylphosphatases 16 8 35 aompkzyqv--lb-efgh---j---- EutG [C] COG1454 Alcohol dehydrogenase IV 17 9 94 aompkz-q-dr-bcefgh--uj---- BisC [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing 11 6 23 aompkzy--d-l-----------it- NtpA [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A 11 6 18 aompkzy--d-l-----------it- NtpB [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B 11 6 18 aompkzy--d-l-----------it- NtpD [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D 10 5 16 aompkzy--d-------------it- NtpE [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E 11 6 21 aompkzy--d-l-----------it- NtpI [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I 22 4 51 aomp-zyqvdrlbcefghsnujx--- GltA [C] COG0372 Citrate synthase 12 13 84 aom---y--drlb-ef--s--j---- - [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases 16 8 30 -o-p-zyq-dr-bc-fg-snujx--- QcrB [C] COG1290 Cytochrome b subunit of the bc complex 16 9 34 ao-p---q--rlbcefgh--ujxi-- CydA [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 14 9 28 -o-----q--rlbcefgh--ujxi-- AppB [C] COG1294 Cytochrome bd-type quinol oxidase, subunit 2 10 8 18 ------yq----b--fg-snujx--- CYT1 [C] COG2857 Cytochrome c1 16 8 56 aompkzyqv-r--cef--sn-j---- FixC [C] COG0644 Dehydrogenases (flavoproteins) 19 6 77 -o-p-zy--drlbcefghsn-jxi-w AceF [C] COG0508 Dihydrolipoamide acyltransferases 23 4 97 aomp-zyqvdrlbcefghsn-jxi-w Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes 14 11 32 ao-p-zy-vdr-b-ef--sn-j---- FixB [C] COG2025 Electron transfer flavoprotein alpha-subunit 14 11 31 ao-p-zy-vdr-b-ef--sn-j---- FixA [C] COG2086 Electron transfer flavoprotein beta-subunit 17 4 29 ------yqv-rlbcefghsnujx--w AtpB [C] COG0356 F0F1-type ATP synthase a subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpA [C] COG0056 F0F1-type ATP synthase alpha subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpD [C] COG0055 F0F1-type ATP synthase beta subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw AtpE [C] COG0636 F0F1-type ATP synthase c subunit/Archaeal/vacuolar-type H+-ATPase subunit K 17 4 31 ------yqv-rlbcefghsnujx--w AtpH [C] COG0712 F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) 17 4 30 ------yqv-rlbcefghsnujx--w AtpC [C] COG0355 F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) 17 4 32 ------yqv-rlbcefghsnujx--w AtpG [C] COG0224 F0F1-type ATP synthase gamma subunit 18 7 100 ao-p-zyq-dr-bcefghsnuj---- GlcD [C] COG0277 FAD/FMN-containing dehydrogenases 18 8 77 aomp-z-q-drlbcefgh-nuj---- GlpC [C] COG0247 Fe-S oxidoreductases 10 7 23 aompkzy-v----c------u----- - [C] COG0731 Fe-S oxidoreductases 15 11 54 a-mpkz--vdrlbcefg----j---- - [C] COG1032 Fe-S oxidoreductases family 2 11 10 38 ao--kz-q------efgh--uj---- HybA [C] COG0437 Fe-S-cluster-containing hydrogenase components 1 6 8 6 -o-----qvd--bc------------ - [C] COG3411 Ferredoxin 15 8 49 ao----yq-dr--cefgh-n-jxi-- Fdx [C] COG0633 Ferredoxin 10 8 16 aom-kz--v-rlbc------------ Fer [C] COG1141 Ferredoxin 1 17 9 96 a-mpkz--vd--bcefghsnuj---- NapF [C] COG1145 Ferredoxin 2 16 8 59 aompk---vdr--cefg-s-ujx--- - [C] COG1146 Ferredoxin 3 11 10 46 -o----y--dr-b-efg-sn-j---- Hmp [C] COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 13 12 38 a-m---y----lbcefghs-u---t- FldA [C] COG0716 Flavodoxins 15 11 39 aompkz--vdr-bcefg-----x--- HyfB [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit 19 5 36 aompkzyqvdr--cef--snujx--- NuoI [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) 17 7 31 -o---zy--dr-bcefghsnujxi-- FumC [C] COG0114 Fumarase 8 9 13 a---k-y-v-r---e-gh-------- GalT [C] COG1085 Galactose-1-phosphate uridylyltransferase 22 5 37 a-m---yqvdrlbcefghsnujxitw GpsA [C] COG0240 Glycerol 3-phosphate dehydrogenase 21 6 33 ao-pkzyqvdrlbcefghs--j--tw GlpK [C] COG0554 Glycerol kinase 15 9 30 -o-p--y--drlbcefghs--j--t- GlpA [C] COG0578 Glycerol-3-phosphate dehydrogenase 17 10 50 -o-pkzy-vdrlb-efgh---j--tw UgpQ [C] COG0584 Glycerophosphoryl diester phosphodiesterase 13 11 27 -o---zyq-dr-bcef--s--jx--- CyoC [C] COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 13 11 30 -o---zyq-dr-bcef--s--jx--- CyoB [C] COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 14 11 33 ao---zyq-dr-bcef--s--jx--- CyoA [C] COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 9 10 15 ------yq-d--b-efg-s-u----- Hmp [C] COG1017 Hemoglobin-like flavoprotein 22 5 41 -ompkzyq-dr-bcefghsnujxi-w Ppa [C] COG0221 Inorganic pyrophosphatase 8 11 11 a-m---y-vd-lb---g--------- PPX1 [C] COG1227 Inorganic pyrophosphatase/exopolyphosphatase 17 8 28 ao-p-zyqvdrlbcef-h--uj---- Icd [C] COG0538 Isocitrate dehydrogenases 20 6 44 aompkzy--drlbcefgh-n-jx-t- LldD [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases 11 11 25 ao-------d--b-efgh-nu---t- LldP [C] COG1620 L-lactate permease 16 11 57 ---pkzyq---lbcefgh-nuj--t- LdhA [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases 23 4 45 aomp-zyqvdrlbce-ghs-ujxitw Mdh [C] COG0039 Malate/lactate dehydrogenases 21 5 42 ao-pkzy-vdrlbcefghsnujx--- SfcA [C] COG0281 Malic enzyme 19 7 202 -omp-zyq-drlbcefgh-nuj---w PutA [C] COG1012 NAD-dependent aldehyde dehydrogenases 12 9 28 -o----y--drlbcefgh---j---- Ndh [C] COG1252 NADH dehydrogenase, FAD-containing subunit 13 6 21 ------yqvdr--cef--snujx--- NuoG [C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) 14 10 54 ao-p--y-vdrlb-efg-s--j---- NemA [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family 18 6 26 ao-pkzyqvdr--cef--snujx--- NuoB [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 13 8 21 --m---yqvdr--cef--sn-jx--- NuoE [C] COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoC [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoD [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 15 8 24 ao-p-z-q-dr--cef--snujx--- NuoH [C] COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H) 14 9 22 -o-p-z-q-dr--cef--snujx--- NuoK [C] COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) 15 8 23 ao-p-z-q-dr--cef--snujx--- NuoN [C] COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N) 13 9 22 -o-p---q-dr--cef--snujx--- NuoA [C] COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A) 13 9 24 -o-p---q-dr--cef--snujx--- NuoM [C] COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M) 18 8 38 ao-pkz-q-dr-bcefg-snujx--- NuoL [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit 15 8 26 ao-p-z-q-dr--cef--snujx--- NuoJ [C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) 13 8 21 --m---yqvdr--cef--sn-jx--- NuoF [C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit 15 10 84 -o-p-zyq-drlb-efghs--j---- Qor [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases 9 13 28 -o--kz------b---gh-nu---t- NhaC [C] COG1757 Na+/H+ antiporter 16 10 39 -o--kz-q-dr-b-efg-s-ujxit- GltP [C] COG1301 Na+/H+-dicarboxylate symporters 19 6 37 ao----yqv-rlb-efgh-nujxitw IscU [C] COG0822 NifU homologs involved in Fe-S cluster formation 21 5 89 aompkz-qvdrlbcefghsnuj---- NfnB [C] COG0778 Nitroreductase 18 5 40 -o------vdrlbcefghsnujx-tw Pta [C] COG0280 Phosphotransacetylase 10 15 24 -om---y-----bcef-----j-it- - [C] COG1413 Phycocyanin alpha-subunit phycocyanobilin lyase and related proteins 6 8 8 ----kzy-v---b--------j---- - [C] COG2421 Predicted acetamidase/formamidase 18 8 94 -o-p-zyqvdrlbcefg-s-uj--t- Tas [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) 13 8 24 ------y--dr-b-efghsn-jxi-- SucA [C] COG0567 Pyruvate and 2-oxoglutarate dehydrogenases, E1 component 11 13 18 a-m-k-yq--rlb--f----uj---- PycA [C] COG1038 Pyruvate carboxylase, C-terminal domain/subunit 18 9 63 aompkzyqv-rlbce-g---uj--t- PorA [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit 18 9 60 aompkzyqv-rlbce-g---uj--t- PorB [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit 17 10 55 aompkz-qv-rlbce-g---uj--t- PorG [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit 16 8 35 -o-p-zyq-dr-bc-fg-snujx--- QcrA [C] COG0723 Rieske Fe-S protein 12 13 21 a-m-k---v-r--cef--sn-j--t- - [C] COG1773 Rubredoxin 21 6 41 aomp-zyq-dr-bcefghsnujxi-- FrdB [C] COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein 17 8 28 ao-p-zy--dr-b-efg-snujxi-- SdhC [C] COG2009 Succinate dehydrogenase/fumarate reductase cytochrome b subunit 23 4 54 aomp-zyqvdrlbcefghsnujxi-- SdhA [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunits 21 6 38 aomp-zyq-dr-bcefghsnujxi-- SucD [C] COG0074 Succinyl-CoA synthetase alpha subunit 21 6 34 aomp-zyq-dr-bcefghsnujxi-- SucC [C] COG0045 Succinyl-CoA synthetase beta subunit 14 9 35 -o-p-zy--drlbc-f-----jxi-w AcoA [C] COG1071 Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunit 14 9 33 -o-p-zy--drlbc-f-----jxi-w AcoB [C] COG0022 Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunit 12 10 20 ------yq-dr-bcefgh---j-i-- GlgB [G] COG0296 1,4-alpha-glucan branching enzyme 25 2 43 aompkzyqvdrlbcefghsnuj-itw Pgk [G] COG0126 3-phosphoglycerate kinase 16 6 35 ------yqvdrlbce-ghs--j-itw PfkA [G] COG0205 6-phosphofructokinase 13 9 23 ------y-v-rlbce-gh-n-j-it- Gnd [G] COG0362 6-phosphogluconate dehydrogenase, family 1 16 6 42 ------y-v-rlbcefghsnuj-it- NagB [G] COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase 15 11 95 ao--kz--vd-lb-efgh---j--tw MglA [G] COG1129 ABC-type sugar (aldose) transport system, ATPase component 18 9 110 -o-pkz--vdrlbcefghs--j--tw MalF [G] COG1175 ABC-type sugar transport systems, permease components 23 4 175 aompkz-qvdrlbcefghsnuj--tw MalK [G] COG1130 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component 9 11 14 ---pk-y-v-rlbce----------- AMS1 [G] COG0383 Alpha-mannosidase 23 4 48 aom-kzyqvdrlbcefghsnujx-t- SuhB [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family 16 6 41 ------y-vdrlbcefghsn-jx-t- BglX [G] COG1472 Beta-glucosidase-related glycosidases 12 10 33 aom-kz--vd-lb-ef---------w FrvX [G] COG1363 Cellulase M and related proteins 10 8 19 aom-kz-q------e--h---j-i-- FbaB [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes 25 2 51 aompkzyqvdrlbcefghsnuj-itw Eno [G] COG0148 Enolase 17 5 42 ------yqvdrlbcefgh-nuj--tw Fba [G] COG0191 Fructose/tagatose bisphosphate aldolase 10 10 15 ----k-y-v-rlb-e-gh------t- GalK [G] COG0153 Galactokinase 11 12 29 ---p--y-vd-lb-e-gh-n-j---- GalM [G] COG2017 Galactose mutarotase and related enzymes 15 11 25 --m-k-yq-drlbcefgh---j-i-- GlgP [G] COG0058 Glucan phosphorylase 18 4 31 ------yqvdrlbcefghsnuj-it- Zwf [G] COG0364 Glucose-6-phosphate 1-dehydrogenase 23 4 41 -omp-zyqvdrlbcefghsnuj-itw Pgi [G] COG0166 Glucose-6-phosphate isomerase 25 2 61 aompkzyqvdrlbcefghsnuj-itw GapA [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase 15 12 36 a-m---y-vd-lbcef-hs--j--tw GlpF [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) 12 12 74 ---p--y-vdrlbcefg----j---- AmyA [G] COG0366 Glycosidases 10 9 28 ------y-v--lb-efgh---j---w MtlD [G] COG0246 Mannitol-1-phosphate/altronate dehydrogenases 16 10 39 aom-k--qv-r-bcefg-snuj---- CpsB [G] COG0662 Mannose-6-phosphate isomerase 13 9 23 ------y-vdrlb-efghs--j--t- NagA [G] COG1820 N-acetylglucosamine-6-phosphate deacetylase 21 6 40 --mp--yqvdrlbcefghsnuj-itw Rpe [G] COG0036 Pentose-5-phosphate-3-epimerase 24 3 215 aompkzyqvd-lbcefghsnujxit- RhaT [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily 26 1 925 aompkzyqvdrlbcefghsnujxitw ProP [GEPR]COG0477 Permeases of the major facilitator superfamily 21 6 43 aompkz-qvdr-bcefg-snujx-t- PpsA [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase 10 11 23 ------y---rl--e--hsn-j-it- GpmA [G] COG0588 Phosphoglycerate mutase 1 15 9 75 ---p--yqvdrlbcefghs--j---- GpmB [G] COG0406 Phosphoglycerate mutase/fructose-2,6-bisphosphatase 26 1 94 aompkzyqvdrlbcefghsnujxitw CpsG [G] COG1109 Phosphomannomutase 11 10 20 a-----y-vdrlb-e-gh------t- ManA [G] COG1482 Phosphomannose isomerase 5 5 8 ----kzyqv----------------- - [G] COG2152 Predicted glycosylase 21 5 32 aompkzyqvdrlbcefg-snuj---- - [G] COG0063 Predicted sugar kinase 15 11 30 ao--kzyqv-rlb-ef----ujx--- NagD [G] COG0647 Predicted sugar phosphatases of the HAD superfamily 15 11 53 ---pk-y-vdrlbcefg-s-uj---- CDA1 [G] COG0726 Predicted xylanase/chitin deacetylase 23 4 53 -ompkzy-vdrlbcefghsnuj-itw PykF [G] COG0469 Pyruvate kinase 19 7 31 aompkzy--d-l-cefghsn-j-it- RpiA [G] COG0120 Ribose 5-phosphate isomerase 21 5 50 aompkzyqv-rlb-efghs-ujx--w AraD [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases 13 13 48 a----zy-v-rlbcef-h---j--t- XylB [G] COG1070 Sugar (pentulose and hexulose) kinases 19 7 112 aompkzy-vdrlbcefghs--j---- RbsK [G] COG0524 Sugar kinases, ribokinase family 18 9 111 -o-pkz--vdrlbcefghs--j--tw MalG [G] COG0395 Sugar permeases 17 10 83 -o-pkz--vdrlbcefghs--j--t- UgpB [G] COG1653 Sugar-binding periplasmic proteins/domains 18 9 40 --mp--yqvdrlbcefgh-nuj-i-- MipB [G] COG0176 Transaldolase 23 4 57 --mpkzyqvdrlbcefghsnuj-itw TktA [G] COG0021 Transketolase 25 2 45 aompkzyqvdrlbcefghsnuj-itw TpiA [G] COG0149 Triosephosphate isomerase 17 8 49 -ompkzy--drlbcefg-sn-j---- CysH [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes 10 12 13 ---pkz--vd-lbc-----n---i-- AroA [E] COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase 12 10 19 aompk-yq---lb-e----n---i-- AroD [E] COG0710 3-dehydroquinate dehydratase 13 8 21 ------y-vdr-bcefghs-uj---- AroQ [E] COG0757 3-dehydroquinate dehydratase II 19 8 32 ---pkzy-vdrlbcefghsnuj-i-- AroB [E] COG0337 3-dehydroquinate synthetase 20 6 36 aom-k-yqvdrlbcefghsnuj---- LeuC [E] COG0065 3-isopropylmalate dehydratase large subunit 19 7 35 a-m-k-yqvdrlbcefghsnuj---- LeuD [E] COG0066 3-isopropylmalate dehydratase small subunit 18 8 30 ---pkzyqvd-lbcefghsnuj---- MetF [E] COG0685 5,10-methylenetetrahydrofolate reductase 23 4 39 aompkzyqvdrlbcefghsnuj-i-- AroA [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase 18 8 136 a----z--vdrlbcefgh-nujxit- ArtI [E] COG0834 ABC-type amino acid transport system, periplasmic component 16 10 117 a----z--vd-lbcefgh-nujxi-- ArtM [E] COG0765 ABC-type amino acid transport system, permease component 11 15 30 a-m--z--vd--bcef----uj---- LivF [E] COG0410 ABC-type branched-chain amino acid transport systems, ATPase component 11 15 30 a-m--z--vd--bcef----uj---- LivG [E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component 12 14 40 aom--z--vd--bcef----uj---- LivK [E] COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component 19 7 91 ao-pkz-qvd-lb-efgh--uj-itw OppF [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 19 7 87 ao-pkz-qvd-lb-efgh--uj-itw DppD [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 21 6 173 ao-pkz-qvdrlbcefgh--uj-itw OppA [EP] COG0747 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components 21 6 125 ao-pkz-qvdrlbcefgh--uj-itw DppB [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 21 6 124 ao-pkz-qvdrlbcefgh--uj-itw DppC [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 16 10 67 a----z--vd-lbcefgh-nujxi-- GlnQ [E] COG1126 ABC-type polar amino acid transport system, ATPase component 15 10 51 ao---z--vd-l--efgh-nuj--tw PotB [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I 15 10 51 ao---z--vd-l--efgh-nuj--tw PotC [E] COG1177 ABC-type spermidine/putrescine transport system, permease component II 19 7 29 aom---yqvdrlbcefghsnuj---- HisG [E] COG0040 ATP phosphoribosyltransferase (histidine biosynthesis) 20 6 37 a-m-kzyqvdrlbcefghsnuj---- IlvH [E] COG0440 Acetolactate synthase, small subunit 20 6 38 a-m-kzyqvdrlbcefghsnuj---- ArgB [E] COG0548 Acetylglutamate kinase 20 6 30 a-m-kzyqvdrlbcefghsnuj---- ArgC [E] COG0002 Acetylglutamate semialdehyde dehydrogenase 22 5 108 a-mpkzyqvdrlb-efghsnujxi-- ArgE [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases 8 7 57 ------y-------efgh-nu--i-- SdaC [E] COG0814 Amino acid permeases 19 7 170 aomp-zy---rlbcefghs--jxi-w PotE [E] COG0531 Amino acid transporters 22 4 41 aompkzyqvdrlbcefghsnuj---- TrpD [E] COG0547 Anthranilate phosphoribosyltransferase 22 4 69 aompkzyqvdrlbcefghsnuj---- TrpE [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I 22 4 51 aompkzyqvdrlbcefghsnuj---- PabA [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II 19 6 51 aompkzy--d-lbcefghsnuj---- SpeB [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family 9 14 13 -o-p------rl---fg----j--tw ArcA [E] COG2235 Arginine deiminase 20 6 31 aomp--yqvdrlbcefghsnuj---- ArgH [E] COG0165 Argininosuccinate lyase 20 6 30 aomp--yqvdrlbcefghsnuj---- ArgG [E] COG0137 Argininosuccinate synthase 15 10 38 aompkzy---rlb-efg-s--j---- AsnB [E] COG0367 Asparagine synthase (glutamine-hydrolyzing) 24 3 44 aompkzyqvdrlbcefghsnujxi-- Asd [E] COG0136 Aspartate-semialdehyde dehydrogenase 24 3 56 aompkzyqvdrlbcefghsnujxi-- LysC [E] COG0527 Aspartokinases 5 7 11 ------y-v-r----f--------t- LAP4 [E] COG1362 Aspartyl aminopeptidase 14 12 67 a-m--z--vd-lbcefg---ujx--- LivM [E] COG0559 Branched-chain amino acid ABC-type transport system, permease components 20 6 66 aom---yqvdrlbcefghsnujx--- IlvE [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase 20 6 41 aomp--yqvdrlbcefghsnuj---- CarB [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) 20 6 36 aomp--yqvdrlbcefghsnuj---- CarA [EF] COG0505 Carbamoylphosphate synthase small subunit 20 6 43 aomp-zyqvdrlb-efghsnuj---- PheA [E] COG1605 Chorismate mutase 23 4 38 aompkzyqvdrlbcefghsnuj-i-- AroC [E] COG0082 Chorismate synthase 19 7 72 -o-pkzy-vdrlbcefghsnuj---- MetC [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases 20 5 52 ao----yqvdrlbcefgh-nujxit- NifS [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes 20 6 63 -o-pkzyqvdrlbcefghsnuj---- CysK [E] COG0031 Cysteine synthase 19 7 45 a-mp--yqvdrlbcefghsnuj---- LysA [E] COG0019 Diaminopimelate decarboxylase 22 5 57 aompkz-qv-rlbcefghsnujxi-- DapA [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase 20 6 49 a-m-kzyqvdrlbcefghsnuj---- IlvD [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase 13 13 35 -o-pkzy-vd--bc-f-hs--j---- DAP2 [E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases 17 5 26 ------yqvdrlbcefghsnuj--t- ProA [E] COG0014 Gamma-glutamyl phosphate reductase 14 10 31 ---p-zy--dr-bcefg-snuj---- Ggt [E] COG0405 Gamma-glutamyltranspeptidase 17 5 28 ------yqvdrlbcefghsnuj--t- ProB [E] COG0263 Glutamate 5-kinase 17 10 44 ao-pkzy-vd--bcef-h-nuj-i-- GdhA [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase 16 10 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0067 Glutamate synthase domain 1 16 10 30 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0069 Glutamate synthase domain 2 16 10 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0070 Glutamate synthase domain 3 19 7 30 aom---yqvdrlbcefghsnuj---- HisH [E] COG0118 Glutamine amidotransferase 23 3 64 aompkzyqvdrlbcefghsnujx--- GlnA [E] COG0174 Glutamine synthase 19 8 34 -o-pkzyqvdrlbcefg-sn-j-i-- GcvH [E] COG0509 Glycine cleavage system H protein (lipoate-binding) 16 10 48 -o-pkzyqvdr-bcef--sn-j---- GcvT [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase) 16 10 25 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain 16 10 24 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain 26 1 53 aompkzyqvdrlbcefghsnujxitw GlyA [E] COG0112 Glycine hydroxymethyltransferase 21 6 120 ao-pkzyq--rlbcefghsnuj-it- DadA [E] COG0665 Glycine/D-amino acid oxidases (deaminating) 19 7 31 aom---yqvdrlbcefghsnuj---- HisD [E] COG0141 Histidinol dehydrogenase 13 9 24 a-mpk-yqvdrlb-e-g--------- HIS2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family 22 4 54 aompkzyqvdrlbcefghsnuj---- HisC [E] COG0079 Histidinol-phosphate aminotransferase/Tyrosine aminotransferase 10 12 18 -om---y--dr----f-hsn-j---- MET2 [E] COG2021 Homoserine acetyltransferase 22 4 43 aompkzyqvdrlbcefghsnuj---- ThrA [E] COG0460 Homoserine dehydrogenase 19 7 30 -ompkzyqvdrlbce-ghs-uj---- ThrB [E] COG0083 Homoserine kinase 19 7 28 aom---yqvdrlbcefghsnuj---- HisB [E] COG0131 Imidazoleglycerol-phosphate dehydratase 19 7 30 aom---yqvdrlbcefghsnuj---- HisF [E] COG0107 Imidazoleglycerol-phosphate synthase 22 4 34 aompkzyqvdrlbcefghsnuj---- TrpC [E] COG0134 Indole-3-glycerol phosphate synthase 20 6 46 a-m-k-yqvdrlbcefghsnujx--- LeuB [E] COG0473 Isocitrate/isopropylmalate dehydrogenase 19 7 58 a-mpk-yqvdr-bcefghsnuj---- LeuA [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases 19 7 31 a-m-k-yqvdrlbcefghsnuj---- IlvC [EH] COG0059 Ketol-acid reductoisomerase 18 6 41 aompkzy--drlb-efghsnu----- AnsB [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D 19 6 130 aom-kzy--drlbcefghsnuj---- GloA [E] COG0346 Lactoylglutathione lyase and related lyases 8 12 16 -o--kz-q-d--b--------j--t- AmpS [E] COG2309 Leucyl aminopeptidase (aminopeptidase T) 20 7 40 a-mpkzyqv-rlb-efghsnuj-i-- MetE [E] COG0620 Methionine synthase II (cobalamin-independent) 11 10 22 a-mp-zyq--r-bc------uj---- HyuA [E] COG0145 N-methylhydaintoinase A 9 10 17 --mp-zyq--r--c------uj---- HyuB [E] COG0146 N-methylhydaintoinase B 19 8 48 ---pkzyqvdrlbcefg-s-ujx-t- GltD [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases 22 5 79 aompkzyq-d--bcefghsnujxit- PutP [EHR] COG0591 Na+/proline, Na+/panthothenate symporters and related permeases 11 11 12 -o----y-vdrlb--f-h--uj---- MET17 [E] COG2873 O-acetylhomoserine sulfhydrylase 10 7 26 -o------vd-lb-------uj-itw - [E] COG1164 Oligoendopeptidase F 24 3 42 aompkzyqvdrlbcefghsnuj--tw ArgF [E] COG0078 Ornithine carbamoyltransferase 22 4 87 aompkzyqvdrlbcefghsnuj---- ArgD [E] COG0160 PLP-dependent aminotransferases 25 2 123 aompkzyqvdrlbcefghsnujxit- AvtA [E] COG0436 PLP-dependent aminotransferases 21 5 61 aompkzyqvdrlbcefghs-uj---- SerA [E] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases 19 7 28 aom---yqvdrlbcefghsnuj---- HisI [E] COG0139 Phosphoribosyl-AMP cyclohydrolase 18 7 27 -om---yqvdrlbcefghsnuj---- HisI [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase 22 5 33 aompkzyqvd-lbcefghsnuj-i-- TrpF [E] COG0135 Phosphoribosylanthranilate isomerase 19 7 28 aom---yqvdrlbcefghsnuj---- HisA [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 17 8 48 aompkzy---rl--efghsnuj---- SerB [E] COG0560 Phosphoserine phosphatase 20 6 31 aomp--yqvdrlbcefghsnuj---- PheA [E] COG0077 Prephenate dehydratase 21 5 32 aomp-zyqvdrlbcefghsnuj---- TyrA [E] COG0287 Prephenate dehydrogenase 12 9 22 -o----y--dr-bcef-h-nuj---- PutA [E] COG0506 Proline dehydrogenase 15 11 67 a-mp-z--vd--bcefghs-uj---- RhtB [E] COG1280 Putative threonine efflux protein 20 7 37 --mp-zyqvdrlbcefghsnuj--t- ProC [E] COG0345 Pyrroline-5-carboxylate reductase 12 13 18 a--pkzy--d--bc--gh--uj---- LYS9 [E] COG1748 Saccharopine dehydrogenase and related proteins 21 5 54 -om-kzy-vdrlbcefghs-uj-itw CsdB [E] COG0520 Selenocysteine lyase 13 9 29 -o------v-rlbcefgh-nuj---- CysE [E] COG1045 Serine acetyltransferase 17 8 30 aompkzyqvd-lbc-fg---uj---- - [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase 23 4 45 aompkzyqvdrlbcefghsnuj-i-- AroE [E] COG0169 Shikimate 5-dehydrogenase 17 5 33 ------yqvdrlbcefghsnuj-i-- AroK [E] COG0703 Shikimate kinase 17 9 33 a-mpkzyqvdr-b-ef--snuj---- SpeE [E] COG0421 Spermidine synthase 14 12 69 ao---z--vd-l-cefgh-n-j--t- PotD [E] COG0687 Spermidine/putrescine-binding periplasmic protein 21 5 103 a-mpkzyqvdrlbcefghsnuj---- IlvB [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] 9 12 16 -o----y-vd--b-efg----j---- GLY1 [E] COG2008 Threonine aldolase 19 6 47 -o-p-zy-vdrlbcefghsnujx--- IlvA [E] COG1171 Threonine dehydratase 19 7 88 ao-pkzy-vdrlb-efghsn-j---w Tdh [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 22 4 48 aompkzyqvdrlbcefghsnuj---- ThrC [E] COG0498 Threonine synthase 13 13 44 a-m-k--qvdr-bc-f-hs--j---- - [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases 23 4 35 aompkzyqvdrlbcefghsnuj-i-- TrpA [E] COG0159 Tryptophan synthase alpha chain 21 6 32 aom-k-yqvdrlbcefghsnuj-i-- TrpB [E] COG0133 Tryptophan synthase beta chain 26 1 84 aompkzyqvdrlbcefghsnujxitw PepP [E] COG0006 Xaa-Pro aminopeptidase 16 11 41 aom---yqvd-lbce-gh--uj--t- UshA [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases 12 11 27 a-m-kz-q-dr--c-fg--n-j---- - [F] COG1051 ADP-ribose pyrophosphatase 19 5 29 ao-p--yqvdrlbcefghsnuj---- PurH [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 20 6 55 -om-kzy-vdrlbcefgh-nuj--tw Apt [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins 23 4 57 ao--k-yqvdrlbcefghsnujxitw Adk [F] COG0563 Adenylate kinase and related kinases 21 5 42 aompk-yqvdrlbcefghsnuj---- PurB [F] COG0015 Adenylosuccinate lyase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurA [F] COG0104 Adenylosuccinate synthase 21 5 34 aompkzyqvdrlbcefg-snuj---- PyrB [F] COG0540 Aspartate carbamoyltransferase, catalytic chain 26 1 44 aompkzyqvdrlbcefghsnujxitw PyrG [F] COG0504 CTP synthase (UTP-ammonia lyase) 14 11 22 -o---zy-vdrlb-e-gh---j--tw Cdd [F] COG0295 Cytidine deaminase 18 8 53 aompkzyqvd--bcef-hs-uj---- SsnA [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases 16 6 36 ------yq-drlbcefghsn-jxi-- - [FJ] COG0590 Cytosine/adenosine deaminases 5 9 8 ------y--------f----uj--t- NUC1 [F] COG1864 DNA/RNA endonuclease G, NUC1 19 8 35 aompkz-q--r-bcef-hsnujxi-- Dcd [F] COG0717 Deoxycytidine deaminase 10 10 16 a--pk-y-vd-lb---g-------t- ComEB [F] COG2131 Deoxycytidylate deaminase 17 10 25 -omp-z-qvdrlbce-gh---j--tw DeoC [F] COG0274 Deoxyribose-phosphate aldolase 25 2 74 aompkzyq-drlbcefghsnujxitw Hit [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases 19 7 44 aompkzyqvdrlbcef--s-uj---- PyrC [F] COG0044 Dihydroorotase 22 4 42 aompkzyqvdrlbcefghsnuj---- PyrD [F] COG0167 Dihydroorotate dehydrogenase 16 5 31 ------yqvdr-bcefghsnujx--- GppA [FP] COG0248 Exopolyphosphatase 18 6 29 -o-p--yqvdrlbcefghsnuj---- PurN [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN 13 9 19 -o-----q-dr-bcefghs-uj---- PurU [F] COG0788 Formyltetrahydrofolate hydrolase 8 13 15 ---p--y-v--l----g--n-j---w MIS1 [F] COG2759 Formyltetrahydrofolate synthetase 24 3 52 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0518 GMP synthase - Glutamine amidotransferase domain 24 3 37 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0519 GMP synthase - PP-ATPase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurF [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase 19 3 39 ------yqvdrlbcefghsnujxi-w Gmk [F] COG0194 Guanylate kinase 23 4 90 -ompkzyqvdrlbcefghsnuj-it- GuaB [F] COG0516 IMP dehydrogenase/GMP reductase 23 4 38 aompkzyq-dr-bcefghsnujxit- Ndk [F] COG0105 Nucleoside diphosphate kinase 23 4 40 aompkzyqvdrlbcefghsnuj-i-- PyrE [F] COG0461 Orotate phosphoribosyltransferase 22 4 36 aompkzyqvdrlbcefghsnuj---- PyrF [F] COG0284 Orotidine-5'-phosphate decarboxylase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurD [F] COG0151 Phosphoribosylamine-glycine ligase 21 5 33 aompk-yqvdrlbcefghsnuj---- PurM [F] COG0150 Phosphoribosylaminoimidazol (AIR) synthetase 17 7 26 -o-p--yqvdrlbcefghsn-j---- PurK [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 22 4 35 aompk-yqvdrlbcefghsnujx--- PurC [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase 21 5 32 aompk-yqvdrlbcefghsnuj---- PurE [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase 14 7 19 aompk--qvdrlbc------uj---- PurS [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain 24 3 52 aompkzyqvdrlbcefghsnuj--tw PrsA [FE] COG0462 Phosphoribosylpyrophosphate synthetase 12 8 19 -o-pkz-qv-r--c------u-xit- THY1 [F] COG1351 Predicted alternative thymidylate synthase 16 10 31 a-mpkzyqv-rlbcef--s--j---- Pnp [F] COG0005 Purine nucleoside phosphorylase 26 1 60 aompkzyqvdrlbcefghsnujxitw NrdA [F] COG0209 Ribonucleotide reductase alpha subunit 20 3 41 -o----yq-drlbcefghsnujxitw NrdF [F] COG0208 Ribonucleotide reductase beta subunit 12 12 18 -o-p----vd-lb-e-gh---j--tw Tdk [F] COG1435 Thymidine kinase 26 1 48 aompkzyqvdrlbcefghsnujxitw Tmk [F] COG0125 Thymidylate kinase 15 10 28 a-m---y--drlb-efghsn-j---w ThyA [F] COG0207 Thymidylate synthase 21 5 32 -om-kzyqvdrlbcefgh-nuj--tw Upp [F] COG0035 Uracil phosphoribosyltransferase 13 6 26 -o----y-vd-lbce-gh-----itw Udk [F] COG0572 Uridine kinase 25 2 42 aompkz-qvdrlbcefghsnujxitw PyrH [F] COG0528 Uridylate kinase 11 10 40 ----k-y-vd-lb-efgh-n------ UraA [F] COG2233 Xanthine/uracil permeases 24 3 38 aompkzyqvdrlbcefghsnuj-it- - [F] COG0127 Xanthosine triphosphate pyrophosphatase 15 7 30 ------yq--rlb-ef-hsnujxit- Dut [F] COG0756 dUTPase 15 11 42 a-mpk-yqv-rlb-efg--n----t- UbiB [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibB [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 19 8 30 a-mpkzyq-d--bcefgh-nujxi-- UbiX [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase 19 8 34 a-mpkzyq-d--bcefgh-nujxi-- UbiD [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases 21 6 42 aompkzyq-d--bcefghsnujxi-- UbiA [H] COG0382 4-hydroxybenzoate polyprenyltransferase 22 3 42 -o-p--yqvdrlbcefghsnujxitw FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase 22 4 35 -om--zyq-drlbcefghsnujxitw - [H] COG0212 5-formyltetrahydrofolate cyclo-ligase 18 8 33 aompk--qv---bcefghsnujx--- - [H] COG0720 6-pyruvoyl-tetrahydropterin synthase 17 5 33 ------yqvdrlbcefghsnuj-i-- FolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 19 8 53 --mpk-yq-dr-bcefghsnujxi-- BioF [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes 15 10 45 -o--kz---d-lbcefgh-nuj--t- TbpA [H] COG1840 ABC-type iron/thiamine transport systems, periplasmic component 14 11 38 -o--kz---d--bcefgh-nuj--t- ThiP [H] COG1178 ABC-type thiamine transport system, permease components 11 13 15 -o-pk---vdr--cefg----j---- BtuR [H] COG2109 ATP:corrinoid adenosyltransferase 15 9 51 --m---yq-dr-b-efghsnuj-i-- BioA [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 12 13 19 -o--k--q--r-bcefg-sn-j---- NadB [H] COG0029 Aspartate oxidase 16 8 34 --m---yqv-r-bcefghsnuj-i-- BioB [H] COG0502 Biotin synthase and related enzymes 23 4 38 aom-k-yqvdrlbcefghsnujxit- BirA [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase 21 6 32 aomp-zyq-dr-bcefghsnujxi-- HemB [H] COG0113 Delta-aminolevulinic acid dehydratase 11 14 17 a-m---y--dr-b-efgh---j---- MenG [H] COG0684 Demethylmenaquinone methyltransferase 26 1 45 aompkzyqvdrlbcefghsnujxitw CoaE [H] COG0237 Dephospho-CoA kinase 15 9 32 --m---yq--r-bcefghsnuj-i-- BioD [H] COG0132 Dethiobiotin synthetase 15 7 40 ------y-vdrlb-efghsn-j-i-w FolA [H] COG0262 Dihydrofolate reductase 15 6 29 ------y--drlbcefghsnuj-i-- FolB [H] COG1539 Dihydroneopterin aldolase 23 4 44 aompkzyqvdrlbcefghsnuj-i-- FolP [H] COG0294 Dihydropteroate synthase 20 6 55 aompkzyq-dr-bcefghsnuj---- ThiF [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 19 3 34 ------yqvdrlbcefghsnuj-itw RibF [H] COG0196 FAD synthase 20 5 38 -o-p--yqvdrlbcefghsnujx-t- FolC [H] COG0285 Folylpolyglutamate synthase 15 6 26 ------yq-drlbcefghs-ujx--- FolE [H] COG0302 GTP cyclohydrolase I 19 6 41 a--p--yqvdrlbcefghsnuj-i-- RibA [H] COG0807 GTP cyclohydrolase II 25 2 78 aompkzyqvdrlbcefghsnujxit- IspA [H] COG0142 Geranylgeranyl pyrophosphate synthase 19 8 35 aomp-z-q-dr-bcefghsnuj-i-- AlsD [H] COG0001 Glutamate-1-semialdehyde aminotransferase 18 8 27 aomp-z-q-dr-bcefghsnu--i-- HemA [H] COG0373 Glutamyl-tRNA reductase 22 5 39 aompkzyqvdrlb-efghsnuj--t- ThiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 17 8 30 -o--kzyqvdr-bcefg-snuj---- PanB [H] COG0413 Ketopantoate hydroxymethyltransferase 13 13 27 ao--kzyq--rlb-efg----j---- ApbA [H] COG1893 Ketopantoate reductase 17 8 27 -o---zyq-dr-bcefghsn-jxi-- LipA [H] COG0320 Lipoate synthase 15 9 42 -o-pkzyqv--lbcefg------i-w LplA [H] COG0095 Lipoate-protein ligase A 18 7 28 ---p--yqvdr-bcefghsnujxi-- UbiE [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaA [H] COG2896 Molybdenum cofactor biosynthesis enzyme 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaC [H] COG0315 Molybdenum cofactor biosynthesis enzyme 17 9 42 aompkz-q-dr-bcefgh--uj---- MoeA [H] COG0303 Molybdopterin biosynthesis enzyme 16 10 30 aompkz-q-dr-b-efgh--uj---- MoaB [H] COG0521 Molybdopterin biosynthesis enzymes 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaE [H] COG0314 Molybdopterin converting factor, large subunit 15 11 33 ao-pk--q-dr-bcefgh--uj---- MoaD [H] COG1977 Molybdopterin converting factor, small subunit 13 11 19 aompkz-q----b-e-gh--uj---- MobB [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein 18 8 29 aompkz-q-dr-bcefgh-nuj---- MobA [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A 23 4 41 aompkzyqvdrlbcefg-snuj--tw NadE [H] COG0171 NAD synthase 16 10 36 a---kzyqvdrlb-efgh--uj---- SIR2 [H] COG0846 NAD-dependent protein deacetylases, SIR2 family 19 7 32 aom-k-yqv-rlbcefghsnuj---- NadC [H] COG0157 Nicotinate-nucleotide pyrophosphorylase 16 6 32 ------yqv-rlbcefg-snuj--tw NadD [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase 23 4 37 ao-pkzyqvdrlbcefghsnuj--tw PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase 15 10 61 ao-p-z--vdrlbcefgh---j---- DgoA [H] COG1441 O-succinylbenzoate synthase and related enzymes 14 7 24 ------yqvdr-bcefg-snuj---- PanC [H] COG0414 Panthothenate synthetase 23 4 45 aompkzyqvdrlbcefghsnuj--t- Dfp [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase 15 10 25 ao-p-zyq-dr-bcef--s--jx--- CyoE [H] COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor) 21 6 33 aomp-zyq-dr-bcefghsnujxi-- HemC [H] COG0181 Porphobilinogen deaminase 12 8 21 aompkzy-vdr-b----h-------- PDX2 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis 18 7 29 ---p--yq-drlbcefghsnujxi-- HemH [H] COG0276 Protoheme ferro-lyase (ferrochelatase) 10 12 15 ao--k-yq-dr-b--------j-i-- HemY [H] COG1232 Protoporphyrinogen oxidase 9 10 12 -o----yq--r--c-fg-s--j---- - [H] COG2154 Pterin-4a-carbinolamine dehydratase 8 12 17 ------y--d-l--ef-h---j--t- PdxK [H] COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase 12 8 21 aompkzy-vdr-b----h-------- SNZ1 [H] COG0214 Pyridoxine biosynthesis enzyme 17 5 28 ------yqvdrlbcefghsnuj-i-- RibD [H] COG0117 Pyrimidine deaminase 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibD [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis 16 10 25 aom-k--qv-r-bcefg-snuj---- NadA [H] COG0379 Quinolinate synthase 18 5 29 -o----yqvdrlbcefghsnuj-i-- RibC [H] COG0307 Riboflavin synthase alpha chain 21 6 34 aom--zyqvdrlbcefghsnuj-i-- RibH [H] COG0054 Riboflavin synthase beta-chain 14 8 21 aompkzyqv-r--c-f--s--j---- SAM1 [H] COG0499 S-adenosylhomocysteine hydrolase 18 4 34 ------yqvdrlbcefghsnuj--tw MetK [H] COG0192 S-adenosylmethionine synthetase 15 11 27 aomp-zyq--r-b-efg-sn-j---- CysG [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) 17 9 24 aompk--q-dr-bcefg-snuj---- ThiS [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis 15 7 26 aompkz--v--lb-efgh------tw ThiI [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase 15 9 42 aomp-z-qvdr-bce-g---u--i-- ThiH [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes 17 9 24 aom-k--qvdr-bcefg-snuj---- ThiC [H] COG0422 Thiamine biosynthesis protein ThiC 18 8 27 aompkz-q--r-bcefghsnuj---- ThiL [H] COG0611 Thiamine monophosphate kinase 18 8 36 a--pk-yq-drlbcefghsnuj---- ThiE [H] COG0352 Thiamine monophosphate synthase 8 8 11 ------y-vd-lb-------uj--t- THI80 [H] COG1564 Thiamine pyrophosphokinase 17 8 27 ---p--yq-dr-bcefghsnujxi-- HemE [H] COG0407 Uroporphyrinogen-III decarboxylase 17 9 39 aomp-zyq-dr-bcefg-sn-j---- CysG [H] COG0007 Uroporphyrinogen-III methylase 19 8 36 aomp--yq-dr-bcefghsnu-xi-- HemD [H] COG1587 Uroporphyrinogen-III synthase 18 4 41 ------yqvdrlbcefghsnujxi-- FabD [I] COG0331 (acyl-carrier-protein) S-malonyltransferase 20 2 81 ------yqvdrlbcefghsnujxitw PlsC [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase 17 9 41 --mp-zyq-drlbcefgh-nuj---- MmsB [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related proteins 18 4 59 ------yqvdrlbcefghsnujxi-- FabB [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase 20 6 120 aompkzy--drlbcefgh--ujx-t- PaaJ [I] COG0183 Acetyl-CoA acetyltransferases 21 6 58 ao--k-yqvdrlbcefghsnujxi-- AccA [I] COG0825 Acetyl-CoA carboxylase alpha subunit 20 7 56 ao--k--qvdrlbcefghsnujxi-- AccD [I] COG0777 Acetyl-CoA carboxylase beta subunit 20 2 59 ------yqvdrlbcefghsnujxitw AcpP [IQ] COG0236 Acyl carrier protein 13 11 187 ao-p-zy--dr-b-efg--n-j---- CaiA [I] COG1960 Acyl-CoA dehydrogenases 14 10 34 -o-p-zy--d--b-efgh-nuj-i-- - [I] COG1607 Acyl-CoA hydrolase 21 5 165 aomp-zy--drlbcefghsnujxi-- CaiC [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 14 10 28 ao-p-zy--drlb-ef-h--uj---- AtoD [I] COG1788 Acyl-CoA:acetate CoA transferase alpha subunit 13 11 27 -o-p-zy--drlb-ef-h--uj---- AtoA [I] COG2057 Acyl-CoA:acetate CoA transferase beta subunit 18 8 64 aomp-zyq-dr-bcefghs-uj---- Acs [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases 22 5 60 ao--k-yqvdrlbcefghsnujxit- AccB [I] COG0511 Biotin carboxyl carrier protein 21 6 70 aom---yq-drlbcefghsnujxit- AccC [I] COG0439 Biotin carboxylase 26 1 48 aompkzyqvdrlbcefghsnujxitw CdsA [I] COG0575 CDP-diglyceride synthetase 9 8 19 a-mpk-yq-----c--------x-t- SEC59 [I] COG0170 Dolichol kinase 16 9 151 ao-p-zyq-drlb-efg-s--jx--- CaiD [I] COG1024 Enoyl-CoA hydratase/carnithine racemase 15 10 60 a--p--y-vdrlbcefg-s--j--t- Aes [I] COG0657 Esterase/lipase 11 10 28 ao---zyq--r--c-fgh------t- FAA1 [I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming) 13 13 32 a---k-y-vdrlb-efgh---j---- PldB [I] COG2267 Lysophospholipase 19 7 74 -om-k-yq-drlbcefghs-ujx-t- PgpB [I] COG0671 Membrane-associated phospholipid phosphatase 8 5 12 a-m-kzyqv-r--------------- INO1 [I] COG1260 Myo-inositol-1-phosphate synthase 25 2 71 aompkzyqv-rlbcefghsnujxitw PgsA [I] COG0558 Phosphatidylglycerophosphate synthase 17 9 31 aom---y--dr-b-efghsnujxi-- Psd [I] COG0688 Phosphatidylserine decarboxylase 14 10 24 aom---y---r-b--f--snujxit- PssA [I] COG1183 Phosphatidylserine synthase 18 7 62 a--p--y-v--lbcefghsnujxi-w Cls [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes 16 6 33 ------yqvdrlb-e-g--nujxitw AcpS [I] COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) 9 11 17 -om---y--dr-bc-----n-j---- ERG9 [I] COG1562 Phytoene/squalene synthetase 11 12 48 ao----y--dr-b-efgh---j---- MaoC [I] COG2030 Predicted acyl dehydratase 8 8 16 a--p-zyq----b--f-----j---- - [I] COG3255 Putative sterol carrier protein 25 2 49 aompkzyqvdrlbcefghsnujxit- UppS [I] COG0020 Undecaprenyl pyrophosphate synthase 18 7 53 aompkzy--dr-bcefgh-nuj---- MhpD [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) 24 3 228 aompkzy-vdrlbcefghsnujx-tw CcmA [Q] COG1131 ABC-type multidrug transport system, ATPase component 21 5 204 -o--k-yqvdrlbcefghsnujxi-w MdlB [Q] COG1132 ABC-type multidrug/protein/lipid transport system, ATPase component 19 8 70 ao-pkzyqv-rlb-efg-snuj--t- PncA [Q] COG1335 Amidases related to nicotinamidase 10 9 73 -o----y--dr-bc-f--s-uj---- CypX [Q] COG2124 Cytochrome P450 23 4 481 ao-pkzyqvdrlbcefghsnujxi-- FabG [QR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 9 15 28 ---p--yq--r-bcef-----j---- - [Q] COG0412 Dienelactone hydrolase and related enzymes 14 11 29 aompk-y-vdrlb--fg----j---- HutI [Q] COG1228 Imidazolonepropionase and related amidohydrolases 23 4 83 aom-kzyqvdrlbcefghsnuj--tw NorM [Q] COG0534 Na+-driven multidrug efflux pump 12 10 35 -o----yq--r-b-ef-hsnuj---- SufI [Q] COG2132 Putative multicopper oxidases 26 1 493 aompkzyqvdrlbcefghsnujxitw SmtA [QR] COG0500 SAM-dependent methyltransferases 15 11 54 ao-pk--q-drlb-efgh--uj---- PaaI [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism 20 6 129 aompkzy-vdrlbcefghs-uj---- - [R] COG0842 ABC-type multidrug transport system, permease component 12 9 33 ao-pkz--vd--bc-f--------tw NosY [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component 23 4 121 aom--z-qvdrlbcefghsnujxitw PhnL [R] COG1136 ABC-type transport systems, involved in lipoprotein release, ATPase components 21 6 104 aom----qvdrlbcefghsnujxit- - [R] COG0577 ABC-type transport systems, involved in lipoprotein release, permease components 17 4 93 ------y--drlbcefghsnujxit- Uup [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains 23 3 65 aompkzyqvdrlbcefghsnuj---w RimI [R] COG0456 Acetyltransferases 18 8 60 -om-k-y-vdrlbcefgh-nuj-i-- WbbJ [R] COG0110 Acetyltransferases (the isoleucine patch superfamily) 14 12 56 -o-pkzy-v-rlbcefg----j---- ARA1 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase 14 8 66 ---p--y--d---cefghsnujx-t- Arp [R] COG0666 Ankyrin repeat proteins 25 2 212 aompkzyqvdrlbcefghsnujxit- - [R] COG0517 CBS domains 17 9 35 --mpk-yq-dr-bcefg-snujx--- PaaY [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 19 7 45 a-mpkzyqvdrlbcef-h-n-jx--- - [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family 13 9 30 a-----yqvdrlb--f--snuj---- - [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase 26 1 81 aompkzyqvdrlbcefghsnujxitw ARC1 [R] COG0073 EMAP domain 15 6 37 aom-kz-qvdrlbc--g-------tw - [R] COG0618 Exopolyphosphatase-related proteins 7 4 10 aom-kzy-v----------------- - [R] COG1635 Flavoproteins, possibly involved in thiazole biosynthesis 11 8 97 aompkzyq-d---c-------j---- - [R] COG1100 GTPases 19 7 28 -om-kz-qvdrlbcefghsn-j-i-- HflX [R] COG2262 GTPases 11 5 23 aompkz-qv--lb------------w - [R] COG1078 HD superfamily phosphohydrolases 11 11 16 aomp-z-q-dr-b--------j-i-- - [R] COG1331 Highly conserved protein containing a thioredoxin domain 16 11 50 ao--kzy-vdrlb-efg-s--j-i-- - [R] COG1073 Hydrolases of the alpha/beta superfamily 15 6 28 ------y--d-lbcefgh-nujxit- - [R] COG0670 Integral membrane protein, interacts with FtsH 17 10 28 aompkz--vdrlbce---s--j-it- - [R] COG0396 Iron-regulated ABC transporter ATPase subunit SufC 16 9 55 aompk---vd-lb-efghsn-j---- RfbX [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 14 12 42 -o-pk---vdrlbcef-h--uj---- AbgB [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase 15 12 32 aompk--q---lbcef-----jxit- PhnP [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I 18 7 39 aompkzy-vdrlbce--h---j-it- ElaC [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 19 8 79 aompkzyqvdr-bcefg-s--j--t- - [R] COG0714 MoxR-like ATPases 12 14 31 a-m---yq-dr-b-efg-s--j---- WrbA [R] COG0655 Multimeric flavodoxin WrbA 12 12 34 aom-k--q----b---gh-nu--it- - [R] COG0733 Na+-dependent transporters of the SNF family 15 10 38 -om-k---vd-lb-efgh-nuj--t- - [R] COG2252 Permeases 18 9 31 aompk-yq--r-b-e-ghsnuj-i-w - [R] COG1881 Phospholipid-binding protein 17 9 39 aompkz-qvdrlbcef-h---j---- - [R] COG0433 Predicted ATPase 18 8 31 aompkz-q----bcefghsnujx--- - [R] COG0603 Predicted ATPase (PP-loop superfamily), confers aluminum resistance 13 9 18 -o-pkzyqvd-lb-e-----uj---- - [R] COG1832 Predicted CoA-binding protein 15 9 53 aompkz-qvdrlbc-f-----j---- - [R] COG0535 Predicted Fe-S oxidoreductases 19 3 33 ------yqvd-lbcefghsnujxitw ThdF [R] COG0486 Predicted GTPase 20 2 35 ------yqvdrlbcefghsnujxitw Obg [R] COG0536 Predicted GTPase 26 1 49 aompkzyqvdrlbcefghsnujxitw - [R] COG0012 Predicted GTPase 12 12 34 --m-kzy-v--lbc--g--n----tw - [R] COG1161 Predicted GTPases 19 5 33 aom-k-yqv--lb-efghsnujx--w - [R] COG0218 Predicted GTPases 14 7 31 aompk--qvd-lb-e-----u---tw - [R] COG1418 Predicted HD superfamily hydrolase 9 12 19 ------yq--r-bcef---n-j---- - [R] COG0385 Predicted Na+-dependent transporter 19 8 35 a--pk-yqvdrlb-efghsnuj-i-- - [R] COG1611 Predicted Rossmann fold nucleotide-binding protein 20 2 34 ------yqvdrlbcefghsnujxitw - [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase 22 5 64 aom---yqvdrlbcefghsnujxit- - [R] COG0042 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family 20 6 41 aompkzy-vdrlbcefghs-uj---- - [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold 18 7 62 -----zyqvdrlbcefghs-ujx-t- PqqL [R] COG0612 Predicted Zn-dependent peptidases 18 8 65 a-mpkz-qvdr-bcefghsn-j---- TldD [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs 21 6 79 aompkzyqvdr-bcefg-snuj--t- - [R] COG0388 Predicted amidohydrolase 13 6 21 ------yq-dr--cefghsn-jx--- - [R] COG0354 Predicted aminomethyltransferase related to GcvT 12 13 30 -om-k-yq--r-b-efg-s--j---- Iap [R] COG2234 Predicted aminopeptidases 17 9 29 a--pkzy-v-r-bcefg-snuj---w - [R] COG0579 Predicted dehydrogenase 16 10 103 --mpk-yqvd-lbcefgh--uj---- MviM [R] COG0673 Predicted dehydrogenases and related proteins 9 4 14 a-mpkzyqv------------j---- - [R] COG1355 Predicted dioxygenase 16 5 27 ------yqvdrlbcefghsnuj---- - [R] COG0325 Predicted enzyme with a TIM-barrel fold 11 10 26 -o----y--dr-bcefgh---j---- - [R] COG0384 Predicted epimerase, PhzC/PhzF homolog 11 10 17 ------y--d-lbcef--s--jxi-- - [R] COG0400 Predicted esterase 16 6 41 ------yqv-rlbcefghsn-jx-t- RssA [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily 9 11 13 aom-k---v---b--f----u---t- - [R] COG1033 Predicted exporters of the RND superfamily 14 7 34 -o----y--drlbcefgh-n-j---w - [R] COG0431 Predicted flavoprotein 8 3 18 aompkzyq------------------ - [R] COG1204 Predicted helicases 6 7 8 ------y-vd-lbc------------ - [R] COG2179 Predicted hydrolase of the HAD superfamily 13 7 33 -om-k---vdrlbc------ujx--w - [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily 19 8 85 -ompk-yqvdrlb-efghsn-j--t- - [R] COG1011 Predicted hydrolases of the HAD superfamily 21 6 90 aompkzy-vdrlbce-gh-n-j-itw Cof [R] COG0561 Predicted hydrolases of the HAD superfamily 22 4 276 ao-p-zyq-drlbcefghsnujx-tw MhpC [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 14 12 33 aom-k--qv-r-bcef--s--j---w - [R] COG0392 Predicted integral membrane protein 24 3 48 aompkzyqv-rlbcefghsnujx-tw - [R] COG0061 Predicted kinase 13 11 18 a-m---yqvdrlbc-f---n-j---- ArgJ [R] COG1364 Predicted kinase related to thiamine pyrophosphokinase 17 10 51 aompkz--vdrlbce---s--j-it- - [R] COG0719 Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufB 12 9 23 ------y--drlb-efg-sn-j--t- - [R] COG1272 Predicted membrane proteins, hemolysin III homologs 14 10 28 aom-k--q-d----efg-snuj---w - [R] COG1451 Predicted metal-dependent hydrolase 11 13 17 -o-pkz-qvdr-b--f-----j---- - [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold 10 14 19 ---pkzy-vd--b--fg----j---- - [R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain 17 9 48 -om-kz-qvdrlbcefg----j-it- - [R] COG1266 Predicted metal-dependent membrane protease 14 11 23 aom--z-qvd--bcefgh-n------ - [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family) 16 10 24 ao-pkzy-vdrlbce-g--n-j---- CinA [R] COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA 8 10 12 a--p-z-q-d--b-------u--i-- - [R] COG1427 Predicted periplasmic solute-binding protein 8 10 12 a--p-z-q-d--b-------u--i-- - [R] COG2107 Predicted periplasmic solute-binding protein 21 6 71 aom-k--qvdrlbcefghsnujx-t- PerM [R] COG0628 Predicted permease 21 5 93 aompkz-qvdrlbcefghsnuj---- - [R] COG0730 Predicted permeases 14 9 30 --m---yqv---bcefghs-ujx--- - [R] COG0679 Predicted permeases 16 8 55 ----k-y-vdrlbcefghsn-j-i-- - [R] COG0637 Predicted phosphatase/phosphohexomutase 21 6 53 aom-k-yq-drlbcefghsnuj--tw Gph [R] COG0546 Predicted phosphatases 15 9 30 aom-kzy-v-rlb-efg-------tw - [R] COG0622 Predicted phosphoesterase 14 11 31 a-m-kzyq--r--cefgh---j-i-- Icc [R] COG1409 Predicted phosphohydrolases 9 7 21 ao-pkzy------------nu---t- - [R] COG2236 Predicted phosphoribosyltransferases 18 9 37 a---kz-qvdrlbcefghs--j-it- MazG [R] COG1694 Predicted pyrophosphatase 18 9 43 -omp-z-q-dr-bcefghsnuj--t- FcbC [R] COG0824 Predicted thioesterase 10 11 29 -o-p----vd----efg-s-uj---- - [R] COG2391 Predicted transporter components 15 10 36 -omp--y---r-bcefghsn-jx--- AarF [R] COG0661 Predicted unusual protein kinase 13 8 29 ------yq-dr-bcefg-snuj---- - [R] COG0523 Putative GTPases (G3E family) 12 14 22 --mpkz--vdrlb-e---s--j---- PaaD [R] COG2151 Putative aromatic ring hydroxylating enzyme 21 6 77 aompkzyq-dr-bcefghs-uj--tw ThiJ [R] COG0693 Putative intracellular protease/amidase 12 9 32 -o----y---rlb-ef-hsnuj---- DltE [R] COG0300 Short-chain dehydrogenases of various substrate specificities 19 6 30 aom--zyqvd---cefghsnuj-it- SurE [R] COG0496 Survival protein, predicted acid phosphatase 23 4 321 aompk-yqvd-lbcefghsnujxit- NrfG [R] COG0457 TPR-repeat-containing proteins 12 12 48 ao--kz--vd-lb--f-----j--tw - [R] COG1079 Uncharacterized ABC-type transport system, permease component 13 9 19 aom-k---vd-lbc-------jxit- BioY [R] COG1268 Uncharacterized ACR 12 14 18 aompk---v-r-bc-f-h---j---- - [R] COG1878 Uncharacterized ACR, predicted metal-dependent hydrolases 21 2 82 -o----yqvdrlbcefghsnujxitw - [R] COG1253 Uncharacterized CBS domain-containing proteins 21 6 99 aompkzyqvdrlbcefgh---j--tw HcaD [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases 13 12 21 ao-p-z-q-dr-b-ef-h--uj---- - [R] COG2041 Uncharacterized enzymes, related to nitrate reductase 22 5 44 aompkzyqvdrlbcefghs-uj--t- GlpG [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) 17 5 30 -o----yqvdrlbcefg-snuj---w CinA [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) 13 9 25 -o---zyq-d--b--fg-snujx--- - [R] COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems 10 12 26 a--pk-y-v---b--f--s-uj---- - [R] COG1524 Uncharacterized proteins of the AP superfamily 8 11 16 a-m-k--q-d---ce-----u----- HybF [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) 13 11 45 ---p-zy---rlbcef--snuj---- AdhP [R] COG1064 Zn-dependent alcohol dehydrogenases 22 4 157 aompkzyqvdrlbcefghsnuj---- GloB [R] COG0491 Zn-dependent hydrolases, including glyoxylases 16 9 27 aompkz-qvdr-bc--g--nuj---- SpoIVFB [R] COG1994 Zn-dependent proteases 13 13 40 ao---z--vd--bcefgh---j--t- - [S] COG1593 Integral membrane protein, possible transporter 18 8 41 a-mpkz-q-d--b-efghsnuj-it- MarC [S] COG2095 Integral membrane proteins of the MarC family 18 6 29 aompkzyqvdr--cefg-s-uj---- - [S] COG0062 Uncharacterized ACR 13 10 23 aompkz-qvdr-b-ef---------- RtcB [S] COG1690 Uncharacterized ACR 13 12 24 a--pkz-qvd--b-efgh---j---- - [S] COG1801 Uncharacterized ACR 9 4 12 aompkz-qv-r--------------- - [S] COG1371 Uncharacterized ACR 18 7 28 aompk--qvdrlbc-f--sn-j--tw - [S] COG1354 Uncharacterized ACR 13 7 23 ------y-vd-lb-efgh-nu---tw - [S] COG1739 Uncharacterized ACR 18 7 38 aom-k-y--drlb-efgh-nu--itw - [S] COG0327 Uncharacterized ACR 14 7 51 ------yq-dr-bcefghsn-jx--- IscA [S] COG0316 Uncharacterized ACR 8 8 10 ao---z-qv-r--c---------i-- - [S] COG1259 Uncharacterized ACR 14 11 21 ao---z--vd--b-efgh-n-j-it- - [S] COG1738 Uncharacterized ACR 9 7 11 aom-kz-qv-----e-----u----- - [S] COG1912 Uncharacterized ACR 14 9 23 a-m-kzyqvdr-bcefg--------- - [S] COG0432 Uncharacterized ACR 9 2 13 aompkzyqv----------------- - [S] COG2078 Uncharacterized ACR 14 8 23 aompkzyq-d----efgh--u----- - [S] COG0585 Uncharacterized ACR 12 12 20 aompkz--vd-l-c-f-----j---- - [S] COG2013 Uncharacterized ACR 14 12 22 aompk---v-rlbce-gh---j---- - [S] COG0393 Uncharacterized ACR 11 7 16 aompk-yqv-r-bc------------ - [S] COG0011 Uncharacterized ACR 11 13 31 ---p--y-vdrlbcef-----j---- BmrU [S] COG1597 Uncharacterized ACR 14 8 22 aom---yqvdrlbce-gh-------- - [S] COG0391 Uncharacterized ACR 14 11 21 a-mpkz-qv-rlb-e--h-nu----- - [S] COG1518 Uncharacterized ACR 10 10 12 ------y-v-r-b--fg-snuj---- - [S] COG1610 Uncharacterized ACR 8 7 11 a--pkz-qv-r-------------t- - [S] COG1656 Uncharacterized ACR 8 8 12 ------yq-----c----snujx--- - [S] COG1565 Uncharacterized ACR 13 11 31 aom-k--q-d---c-fg--nuj--t- - [S] COG1432 Uncharacterized ACR 8 13 12 -om-k---v----c----s--j--t- - [S] COG1430 Uncharacterized ACR 10 11 37 -om-k---v-----e-gh-nu----w - [S] COG1479 Uncharacterized ACR 15 11 35 ao-pkz-qvdr-bc-fg----j--t- - [S] COG1721 Uncharacterized ACR 20 2 37 ------yqvdrlbcefghsnujxitw - [S] COG0217 Uncharacterized ACR 12 7 19 aom-k--q-d-lbc---------itw - [S] COG1624 Uncharacterized ACR 13 13 23 a--pkzyqvdrl--ef-----j---- - [S] COG2110 Uncharacterized ACR related to the C-terminal domain of histone macroH2A1 7 6 10 ------yqvd-lb-----------t- - [S] COG1774 Uncharacterized ACR, PSP1 homologs 12 9 23 -ompk--qv-rlbc------uj---- - [S] COG1917 Uncharacterized ACR, double-stranded beta-helix domain 15 11 35 a-mp--y-vdrlbc-f-hsn-j---- - [S] COG0599 Uncharacterized ACR, homolog of gamma-carboxymuconolactone decarboxylase subunit 7 10 9 -o-p-z-q-d--bc------------ - [S] COG1547 Uncharacterized BCR 11 12 21 a-mpkzy-vd-l---f-----j---- - [S] COG1814 Uncharacterized membrane proteins 15 12 34 aom-k---vdr-b-efg-s--jx-t- - [S] COG1520 Uncharacterized proteins of WD40-like repeat family LUCA3.0 Total number of events, gains and losses are 18156 4461 13695 Total inconsistency = 27078 1211 COGs number of species/inconsistency (number of events)/number of genes 12 13 21 a-mpkz-qvd--b-ef-----j---- LigT [J] COG1514 2'-5' RNA ligase 23 4 59 aompkz-qvdr-bcefghsnujxit- MiaB [J] COG0621 2-methylthioadenine synthetase 18 8 99 -o-pk-y-vdrlb-efgh-nujx--w RimL [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw AlaS [J] COG0013 Alanyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw ArgS [J] COG0018 Arginyl-tRNA synthetase 20 5 73 aom--zyqvdrlbc-f---nujxitw GatA [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases 20 5 34 aom--zyqvdrlbc-f---nujxitw GatB [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) 19 6 30 aom--z-qvdrlbc-f---nujxitw GatC [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit 20 2 35 ------yqvdrlbcefghsnujxitw AspS [J] COG0173 Aspartyl-tRNA synthetase 17 8 43 aompkzy--d-lbce-ghs-----tw AsnS [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases 25 2 44 ao-pkzyqvdrlbcefghsnujxitw CysS [J] COG0215 Cysteinyl-tRNA synthetase 12 8 19 ------yqvdrlb-efgh-n------ Dtd [J] COG1490 D-Tyr-tRNAtyr deacylase 26 1 50 aompkzyqvdrlbcefghsnujxitw KsgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) 26 1 85 aompkzyqvdrlbcefghsnujxitw TufB [JE] COG0050 GTPases - translation elongation factors 26 1 75 aompkzyqvdrlbcefghsnujxitw GlnS [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases 11 6 20 aompkzy--dr-------------tw GRS1 [J] COG0423 Glycyl-tRNA synthetase, class II 26 1 58 aompkzyqvdrlbcefghsnujxitw HisS [J] COG0124 Histidyl-tRNA synthetase 26 1 46 aompkzyqvdrlbcefghsnujxitw IleS [J] COG0060 Isoleucyl-tRNA synthetase 26 1 48 aompkzyqvdrlbcefghsnujxitw LeuS [J] COG0495 Leucyl-tRNA synthetase 9 7 14 aompkz---------------jx-t- LysS [J] COG1384 Lysyl-tRNA synthetase class I 17 4 37 ------yqvdrlbcefghsnu--i-w LysU [J] COG1190 Lysyl-tRNA synthetase class II 26 1 55 aompkzyqvdrlbcefghsnujxitw Map [J] COG0024 Methionine aminopeptidase 20 2 40 ------yqvdrlbcefghsnujxitw Fmt [J] COG0223 Methionyl-tRNA formyltransferase 26 1 48 aompkzyqvdrlbcefghsnujxitw MetG [J] COG0143 Methionyl-tRNA synthetase 14 7 28 aomp--y-------efghsn-jx-t- FtsJ [J] COG0293 Methyltransferase involved in cell division 8 3 12 aompkzyq------------------ TRM1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase 8 3 12 aompkzyq------------------ eRF1 [J] COG1503 Peptide chain release factor eRF1 20 2 37 ------yqvdrlbcefghsnujxitw Pth [J] COG0193 Peptidyl-tRNA hydrolase 26 1 46 aompkzyqvdrlbcefghsnujxitw PheS [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit 26 1 46 aompkzyqvdrlbcefghsnujxitw PheT [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit 10 3 15 aompkzyqv-r--------------- GCD14 [J] COG2519 Predicted SAM-dependent methyltransferase involved in tRNA-Met maturation 12 10 20 aompkzy--d---c-fg----j---- YSH1 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing 25 2 58 aompk-yqvdrlbcefghsnujxitw HemK [J] COG2890 Predicted rRNA or tRNA methylase 20 2 39 ------yqvdrlbcefghsnujxitw TrmU [J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain 26 1 47 aompkzyqvdrlbcefghsnujxitw ProS [J] COG0442 Prolyl-tRNA synthetase 20 2 36 ------yqvdrlbcefghsnujxitw PrfA [J] COG0216 Protein chain release factor A 19 3 41 ------yqvdrlbcefghsnujxit- PrfB [J] COG1186 Protein chain release factor B 26 1 45 aompkzyqvdrlbcefghsnujxitw TruB [J] COG0130 Pseudouridine synthase 25 2 46 aompk-yqvdrlbcefghsnujxitw TruA [J] COG0101 Pseudouridylate synthase (tRNA psi55) 20 2 101 ------yqvdrlbcefghsnujxitw RluA [J] COG0564 Pseudouridylate synthases, 23S RNA-specific 25 2 54 aompkzyqvdrlbcefghsn-jxitw SUA5 [J] COG0009 Putative translation factor (SUA5) 19 6 76 -o--kzyqvdrlbcefghsnuj---- TdcF [J] COG0251 Putative translation initiation inhibitor 23 4 38 aompkz-qvd-lbcefghsnujxit- Tgt [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase 18 8 31 a-mpkzyq-dr-b-efghsn-jx--- Rph [J] COG0689 RNase PH 10 8 18 ------y---r--cefghs--jx--- Rnd [J] COG0349 Ribonuclease D 17 9 35 -o--kz-qv-r-bcefghsn-jxi-- CafA [J] COG1530 Ribonucleases G and E 10 6 26 aompkzy-v--lb------------- RPL8A [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a) 26 1 47 aompkzyqvdrlbcefghsnujxitw RplA [J] COG0081 Ribosomal protein L1 26 1 49 aompkzyqvdrlbcefghsnujxitw RplJ [J] COG0244 Ribosomal protein L10 26 1 49 aompkzyqvdrlbcefghsnujxitw RplK [J] COG0080 Ribosomal protein L11 26 1 48 aompkzyqvdrlbcefghsnujxitw RplM [J] COG0102 Ribosomal protein L13 26 1 47 aompkzyqvdrlbcefghsnujxitw RplN [J] COG0093 Ribosomal protein L14 26 1 45 aompkzyqvdrlbcefghsnujxitw RplO [J] COG0200 Ribosomal protein L15 26 1 48 aompkzyqvdrlbcefghsnujxitw RplP [J] COG0197 Ribosomal protein L16/L10E 20 2 35 ------yqvdrlbcefghsnujxitw RplQ [J] COG0203 Ribosomal protein L17 26 1 44 aompkzyqvdrlbcefghsnujxitw RplR [J] COG0256 Ribosomal protein L18 20 2 35 ------yqvdrlbcefghsnujxitw RplS [J] COG0335 Ribosomal protein L19 26 1 45 aompkzyqvdrlbcefghsnujxitw RplB [J] COG0090 Ribosomal protein L2 26 1 48 aompkzyqvdrlbcefghsnujxitw RplV [J] COG0091 Ribosomal protein L22 26 1 43 aompkzyqvdrlbcefghsnujxitw RplW [J] COG0089 Ribosomal protein L23 26 1 44 aompkzyqvdrlbcefghsnujxitw RplX [J] COG0198 Ribosomal protein L24 20 2 35 ------yqvdrlbcefghsnujxitw RpmA [J] COG0211 Ribosomal protein L27 20 2 35 ------yqvdrlbcefghsnujxitw RpmB [J] COG0227 Ribosomal protein L28 26 1 44 aompkzyqvdrlbcefghsnujxitw RpmC [J] COG0255 Ribosomal protein L29 26 1 46 aompkzyqvdrlbcefghsnujxitw RplC [J] COG0087 Ribosomal protein L3 22 5 39 aompkzyqvdrlb-efghsn-jx-t- RpmD [J] COG1841 Ribosomal protein L30/L7E 19 3 33 ------yqvd-lbcefghsnujxitw RpmF [J] COG0333 Ribosomal protein L32 20 2 40 ------yqvdrlbcefghsnujxitw RpmG [J] COG0267 Ribosomal protein L33 20 2 34 ------yqvdrlbcefghsnujxitw RpmH [J] COG0230 Ribosomal protein L34 20 2 34 ------yqvdrlbcefghsnujxitw RpmI [J] COG0291 Ribosomal protein L35 20 2 39 ------yqvdrlbcefghsnujxitw RpmJ [J] COG0257 Ribosomal protein L36 26 1 47 aompkzyqvdrlbcefghsnujxitw RplD [J] COG0088 Ribosomal protein L4 26 1 47 aompkzyqvdrlbcefghsnujxitw RplE [J] COG0094 Ribosomal protein L5 26 1 47 aompkzyqvdrlbcefghsnujxitw RplF [J] COG0097 Ribosomal protein L6 20 2 36 ------yqvdrlbcefghsnujxitw RplL [J] COG0222 Ribosomal protein L7/L12 19 3 35 ------yqvdrlbcefghsnujxit- RpsA [J] COG0539 Ribosomal protein S1 5 7 10 ------y-vd-lb------------- VacB [J] COG1098 Ribosomal protein S1 domains 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsJ [J] COG0051 Ribosomal protein S10 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsK [J] COG0100 Ribosomal protein S11 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsL [J] COG0048 Ribosomal protein S12 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsM [J] COG0099 Ribosomal protein S13 26 1 50 aompkzyqvdrlbcefghsnujxitw RpsN [J] COG0199 Ribosomal protein S14 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsO [J] COG0184 Ribosomal protein S15P/S13E 20 2 35 ------yqvdrlbcefghsnujxitw RpsP [J] COG0228 Ribosomal protein S16 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsQ [J] COG0186 Ribosomal protein S17 20 2 36 ------yqvdrlbcefghsnujxitw RpsR [J] COG0238 Ribosomal protein S18 26 1 45 aompkzyqvdrlbcefghsnujxitw RpsS [J] COG0185 Ribosomal protein S19 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsB [J] COG0052 Ribosomal protein S2 26 1 44 aompkzyqvdrlbcefghsnujxitw RpsC [J] COG0092 Ribosomal protein S3 26 1 49 aompkzyqvdrlbcefghsnujxitw RpsD [J] COG0522 Ribosomal protein S4 and related proteins 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsE [J] COG0098 Ribosomal protein S5 20 2 35 ------yqvdrlbcefghsnujxitw RpsF [J] COG0360 Ribosomal protein S6 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsG [J] COG0049 Ribosomal protein S7 26 1 47 aompkzyqvdrlbcefghsnujxitw RpsH [J] COG0096 Ribosomal protein S8 26 1 46 aompkzyqvdrlbcefghsnujxitw RpsI [J] COG0103 Ribosomal protein S9 20 2 36 ------yqvdrlbcefghsnujxitw Frr [J] COG0233 Ribosome recycling factor 17 9 45 ----k-yqv-rlbcefghsnuj-i-- TrmA [J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase 26 1 46 aompkzyqvdrlbcefghsnujxitw SerS [J] COG0172 Seryl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw ThrS [J] COG0441 Threonyl-tRNA synthetase 26 1 80 aompkzyqvdrlbcefghsnujxitw FusA [J] COG0480 Translation elongation and release factors (GTPases) 26 1 52 aompkzyqvdrlbcefghsnujxitw Efp [J] COG0231 Translation elongation factor P/translation initiation factor eIF-5A 26 1 49 aompkzyqvdrlbcefghsnujxitw InfB [J] COG0532 Translation initiation factor 2 (GTPase) 26 1 46 aompkzyqvdrlbcefghsnujxitw InfA [J] COG0361 Translation initiation factor IF-1 13 11 17 a-mpkzyqv---bc-f--s--j---- GCN3 [J] COG0182 Translation initiation factor eIF-2B alpha subunit 8 3 18 aompkzy-v----------------- GCD2 [J] COG1184 Translation initiation factor eIF-2B delta subunit 26 1 49 aompkzyqvdrlbcefghsnujxitw TrpS [J] COG0180 Tryptophanyl-tRNA synthetase 26 1 50 aompkzyqvdrlbcefghsnujxitw TyrS [J] COG0162 Tyrosyl-tRNA synthetase 26 1 45 aompkzyqvdrlbcefghsnujxitw ValS [J] COG0525 Valyl-tRNA synthetase 14 9 22 aomp-z---d---cefghsn-j---- LasT [J] COG0565 rRNA methylase 21 4 68 a-----yqvdrlbcefghsnujxitw SpoU [J] COG0566 rRNA methylases 21 6 54 aom-kzy-vdrlbcefghsnuj-i-- Sun [J] COG0144 tRNA and rRNA cytosine-C5-methylases 19 3 32 ------yqvdrlbcefghsnujxit- MiaA [J] COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase 19 3 50 ------yqvdrlbcefghsnujxit- PcnB [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase 15 7 66 -o-----qvdrlb-efghsn-jx--- CspC [K] COG1278 Cold shock proteins 26 1 46 aompkzyqvdrlbcefghsnujxitw RpoA [K] COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw RpoB [K] COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) 26 1 63 aompkzyqvdrlbcefghsnujxitw RpoC [K] COG0086 DNA-directed RNA polymerase beta' subunit/160 kD subunit (split gene in archaea and Syn) 24 3 38 aompkzyqvdrlbcefghsnujx-t- RpoZ [K] COG1758 DNA-directed RNA polymerase subunit K/omega 7 4 11 aompk-y-v----------------- ELP3 [K] COG1243 ELP3 component of the RNA polymerase II complex, consists of an N-terminal BioB/LipA-like domain and a C-terminal histone acetyltransferase domain (only BioB/LipA-like domain in Thermotoga) 19 4 48 -o----yqvd-lbcefghsnuj-itw VacB [K] COG0557 Exoribonucleases 24 3 309 aompkzyqvdrlbcefghsnuj-i-w WecD [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases 16 11 35 aompkz--vdrlb-e---s--j-it- TroR [K] COG1321 Mn-dependent transcriptional regulator 14 6 22 aompkzy-vd-lbc------u---t- - [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP 15 10 29 a--pk---vdrlbc-f--sn-j--tw - [K] COG1386 Predicted transcriptional regulator containing the HTH domain 17 8 62 aomp-z---drlbcefghs-uj---- - [K] COG1733 Predicted transcriptional regulators 21 5 148 aompkz-qvdrlbcefghsnuj---- ArsR [K] COG0640 Predicted transcriptional regulators 14 12 65 aompkz--vdrlb-e-g----j---- - [K] COG1695 Predicted transcriptional regulators 6 5 8 a-m-kz-qv----------------- - [K] COG1318 Predicted transcriptional regulators 15 11 42 aomp---qv---bcefgh-nuj---- SirA [K] COG0425 Predicted transcriptional regulators 9 13 19 aom-k----d-lb--f-----j---- - [K] COG1476 Predicted transcriptional regulators 20 7 57 aom-kz-q-drlb-efg-snujxit- Spo0J [K] COG1475 Predicted transcriptional regulators 11 14 22 aompkz----r-b-e---s--j---- - [K] COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain 10 11 19 aom-kz---d--b-e-----uj---- NikR [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain 8 10 21 ---pkzy----lb----h--u----- TenA [K] COG0819 Putative transcription activator 9 7 14 aom-kzyq------ef---------- RCL1 [K] COG0430 RNA phosphate cyclase 5 9 81 ------y------c--g---u---t- - [K] COG0724 RNA-binding proteins (RRM domain) 19 7 74 ao-pkzy-vdrlbcefghs----i-w HepA [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family 26 1 48 aompkzyqvdrlbcefghsnujxitw NusG [K] COG0250 Transcription antiterminator 25 2 47 aompkz-qvdrlbcefghsnujxitw NusA [K] COG0195 Transcription terminator 20 6 307 aom-k--qvdrlbcefghsnuj---w AcrR [K] COG1309 Transcriptional regulator 16 10 443 a-m----q-drlbcefghsnuj---- LysR [K] COG0583 Transcriptional regulator 12 10 47 -o-----qvdr-b-efgh--uj---- IclR [K] COG1414 Transcriptional regulator 6 11 10 ------y--d--b--f--s--j---- PaiB [K] COG2808 Transcriptional regulator 17 9 149 aompkz--vdrlb-efg-sn-j---- MarR [K] COG1846 Transcriptional regulators 16 10 73 ao-p-z-qvdrlbce-gh---j--t- NagC [K] COG1940 Transcriptional regulators 15 10 153 aompkz---dr-b-efgh-n-j---- Lrp [K] COG1522 Transcriptional regulators 14 12 63 ---pkzy-vdrlb-efgh---j---- ARO8 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs 20 2 43 ------yqvdrlbcefghsnujxitw Rnc [K] COG0571 dsRNA-specific ribonuclease 15 10 25 aom-kzy--dr-bcefg-s--j---- AlkA [L] COG0122 3-Methyladenine DNA glycosylase 26 1 61 aompkzyqvdrlbcefghsnujxitw Exo [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 17 8 28 -om--z---drlb-efghsnuj-it- MutY [L] COG1194 A/G-specific DNA glycosylase 16 10 40 aompkzyq--r-b--fgh-nuj---- CDC9 [L] COG1793 ATP-dependent DNA ligase 15 6 26 ------y---rlb-efghsnujxit- RecB [L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) 16 9 31 --m---y--drlb-efghsnuj-it- RecD [L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member 16 10 21 aompkz-qvd-lbcefg-------t- SbcC [L] COG0419 ATPase involved in DNA repair 25 2 75 aompkzyqvdrlbcefghsnu-xitw HolB [L] COG0470 ATPase involved in DNA replication 23 2 63 ao-p--yqvdrlbcefghsnujxitw GyrA [L] COG0188 DNA gyrase (topoisomerase II) A subunit 23 2 62 ao-p--yqvdrlbcefghsnujxitw GyrB [L] COG0187 DNA gyrase (topoisomerase II) B subunit 18 5 34 -o----yqvd-lbcefghsn-jxit- MutL [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) 15 10 41 -ompk---vd-lb-e-ghsnuj---- - [L] COG0863 DNA modification methylase 12 10 32 ao-pkzy--drl--e-g-------t- SSL2 [L] COG1061 DNA or RNA helicases of superfamily II 19 3 31 ------yqvdrlbcefghsnujxit- PolA [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains 26 1 47 aompkzyqvdrlbcefghsnujxitw DnaN [L] COG0592 DNA polymerase III beta subunit 21 4 63 a--p--yqvdrlbcefghsnujxit- DnaQ [L] COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonucleases 6 11 8 --mp--yq-d--b------------- POL4 [L] COG1796 DNA polymerase IV (family X) 25 2 46 aompkz-qvdrlbcefghsnujxitw DnaG [L] COG0358 DNA primase (bacterial type) 18 8 27 aompkzyqvdrlbcefg-------t- SbcD [L] COG0420 DNA repair exonuclease 11 13 20 a-mpkz--v-r-bc-f-----j---- SplB [L] COG1533 DNA repair photolyase 11 13 14 ao-pkz-qvd--b-e---s------- Nfi [L] COG1515 Deoxyinosine 3'endonuclease (endonuclease V) 10 14 17 -om---y----l-cefg--n-j---- PhrB [L] COG0415 Deoxyribodipyrimidine photolyase 5 9 9 --mp---qv-----------u----- - [L] COG2231 Endonuclease III related proteins 14 9 27 -ompkzyqv-r-b-e-g------i-w Nfo [L] COG0648 Endonuclease IV 21 5 36 -om----qvdrlbcefghsnujxitw UvrA [L] COG0178 Excinuclease ATPase subunit 19 7 38 a-mp--y--drlbcefghsnujx-t- XthA [L] COG0708 Exonuclease III 14 6 29 ------y--drlbcefghsn-j---w Nei [L] COG0266 Formamidopyrimidine-DNA glycosylase 7 10 9 ------y--d----e--h-nuj---- Mug [L] COG3663 G:T/U mismatch-specific DNA glycosylase 21 5 35 -om----qvdrlbcefghsnujxitw UvrB [L] COG0556 Helicase subunit of the DNA excision repair complex 10 8 36 ------y--d----efghsn-j--t- HrpA [L] COG1643 HrpA-like helicases 25 2 219 aompkz-qvdrlbcefghsnujxitw XerC [L] COG0582 Integrase 10 8 64 --mpkzyq-dr-bc------------ - [L] COG1372 Inteins 22 5 47 aompkzyqv-rlb-efghsnuj-it- Ada [L] COG0350 Methylated DNA-protein cysteine methyltransferase 23 3 58 --m-kzyqvdrlbcefghsnujxitw TatD [L] COG0084 Mg-dependent DNase 12 11 24 -om-k-yq----b--f-h-nuj---w - [L] COG1525 Micrococcal nuclease (thermonuclease) homologs 11 8 17 -om-k--qvd-lbc------u---t- - [L] COG1193 MutS-like ATPases involved in mismatch repair, family 1 19 6 42 -o-p--yqvd-lbcefghsn-jxit- MutS [L] COG0249 MutS-like ATPases involved in mismatch repair, family 2 8 10 12 ------y--dr---efgh---j---- NPY1 [L] COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding 24 3 198 aomp-zyqvdrlbcefghsnujxit- MutT [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes 21 5 40 -om----qvdrlbcefghsnujxitw UvrC [L] COG0322 Nuclease subunit of the excinuclease complex 13 8 38 -o----y---rlbcefgh-n-j---w DinP [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair 25 2 47 aompkzyqvdrlbcefghsnujxit- Nth [L] COG0177 Predicted EndoIII-related endonuclease 12 11 56 -o-p----vd--b-efgh-nuj---- - [L] COG1943 Predicted transposase 13 11 88 -ompk--qvdr--ce---s-u---t- - [L] COG0675 Predicted transposases 6 12 15 aom----q----------s--j---- - [L] COG3316 Putative transposase 17 9 36 -ompkzyq--rlb-efghsn-j---- DinG [L] COG1199 Rad3-related DNA helicases 26 1 62 aompkzyqvdrlbcefghsnujxitw RecA [L] COG0468 RecA/RadA recombinase 8 8 12 a-m-kz-qv--lb------------- - [L] COG1468 RecB family exonuclease 15 10 50 aompk-----rl--efghs-uj---w HsdS [L] COG0732 Restriction endonuclease S subunits 14 9 32 aom-k------l--efghsnuj---w HsdR [L] COG0610 Restriction enzymes type I helicase subunits and related helicases 6 5 11 a-m-kz-qv----------------- - [L] COG1110 Reverse gyrase 16 6 31 -o----y--dr-bcefghsnujx-t- RnhA [L] COG0328 Ribonuclease HI 25 2 39 aompkzyqvdrlbcefghsnujxit- RnhB [L] COG0164 Ribonuclease HII 20 2 50 ------yqvdrlbcefghsnujxitw Ssb [L] COG0629 Single-stranded DNA-binding protein 22 5 48 aompk--qvd-lbcefghsnujxit- RecJ [L] COG0608 Single-stranded DNA-specific exonuclease 12 13 18 --mpk-------bce-ghsnu---t- Dam [L] COG0338 Site-specific DNA methylase 9 8 17 a-mpk--q---lb-----------tw - [L] COG1658 Small primase-like proteins (Toprim domain) 14 8 23 -o-------d-lbcefghs-ujx-t- Dps [L] COG0783 Starvation-inducible DNA-binding protein 23 4 78 -omp--yqvdrlbcefghsnujxitw UvrD [L] COG0210 Superfamily I DNA and RNA helicases 15 9 42 aompk-yqv-r--cef--s-u----w - [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits 21 6 165 a-mp--yq-drlbcefghsnujx-tw SrmB [LKJ] COG0513 Superfamily II DNA and RNA helicases 14 10 23 -----zy--d-lbcefghsn-j--t- RecQ [L] COG0514 Superfamily II DNA helicase 5 6 6 a-mp---qv----------------- - [L] COG1059 Thermostable 8-oxoguanine DNA glycosylase 26 1 59 aompkzyqvdrlbcefghsnujxitw TopA [L] COG0550 Topoisomerase IA 6 13 46 -o-p-----d-l--e------j---- - [L] COG3436 Transposase 15 10 40 aom-k-----rl--efghsnuj---w HsdM [L] COG0286 Type I restriction-modification system methyltransferase subunit 10 15 29 -omp-----d--b-e----nuj--t- - [L] COG1002 Type II restriction enzyme, methylase subunits 15 6 26 ------y-vdrlb-efghsnuj---w - [L] COG2256 Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase 15 5 28 ------y--drlb-efghsnu--itw Ung [L] COG0692 Uracil DNA glycosylase 18 9 34 ao-pkz-qvdrl-c--gh-nujx-t- - [L] COG1573 Uracil-DNA glycosylase 18 6 40 aompk---v--lb-efghsnu--itw TopA [L] COG0551 Zn-finger domain associated with topoisomerase type I 20 7 92 -ompk--q-dr-bcefg-snujxitw Soj [D] COG1192 ATPases involved in chromosome partitioning 22 4 55 aompkzyqvdr-bcefghsnujx--- Mrp [D] COG0489 ATPases involved in chromosome partitioning 12 13 36 aom-k--qv-r-b--fg---u---t- - [D] COG0455 ATPases involved in chromosome partitioning 23 4 57 aompk--qvdrlbcefghsnujx-tw FtsZ [D] COG0206 Cell division GTPase 19 6 41 aompk-yqvdrlbc-f--sn-j--tw Smc [D] COG1196 Chromosome segregation ATPases 17 8 46 a-mp--yqv---b-efghs-ujxit- MreB [D] COG1077 HSP70 class molecular chaperones involved in cell morphogenesis 18 7 32 -om-k-yqvdr-bcefghsnuj---- CrcB [D] COG0239 Integral membrane protein possibly involved in chromosome condensation 19 3 34 ------yqvd-lbcefghsnujxitw GidA [D] COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division 18 8 36 ----k-yqvdr-bcefghsnujxi-- Maf [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation 26 1 79 aompkzyqvdrlbcefghsnujxitw MesJ [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control 16 9 36 a----z-q-dr-bcefghsnujx--- CcmC [O] COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component 6 14 7 a-m----q-d----e------j---- DraG [O] COG1397 ADP-ribosylglycohydrolase 17 4 34 ------yqvd--b-efghsnujxitw Lon [O] COG0466 ATP-dependent Lon protease, bacterial type 20 2 50 ------yqvdrlbcefghsnujxitw HflB [O] COG0465 ATP-dependent Zn proteases 19 3 32 ------yqvdrlbcefghsnujxit- ClpX [O] COG1219 ATP-dependent protease Clp, ATPase subunit 14 9 70 aompkzy--dr-bc-f----uj---- SpoVK [O] COG0464 ATPases of the AAA+ class 21 5 81 --m---yqvdrlbcefghsnujxitw ClpA [O] COG0542 ATPases with chaperone activity, ATP-binding subunit 26 1 80 aompkzyqvdrlbcefghsnujxitw GroL [O] COG0459 Chaperonin GroEL (HSP60 family) 20 2 38 ------yqvdrlbcefghsnujxitw GroS [O] COG0234 Co-chaperonin GroES (HSP10) 18 7 33 -om---y--drlbcefghsnuj--tw - [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase 15 9 22 a-m-kz-qvdrlbc---h--uj--t- CcdA [O] COG0785 Cytochrome c biogenesis protein 10 8 23 ------y------cefgh-nujx--- DjlA [O] COG1076 DnaJ-domain-containing proteins 1 12 7 35 ------y--d---cefghsn-j-it- FkpA [O] COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 15 7 28 aompkz---d----efghsnu---t- SlpA [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 20 7 57 aom-k-y-vdrlbcefghsn-jx-t- GrxC [O] COG0695 Glutaredoxin and related proteins 11 8 22 -o----y------cefghsn-jx--- - [O] COG0278 Glutaredoxin-related proteins 10 10 25 ------y----lbcef--sn-j---w BtuE [O] COG0386 Glutathione peroxidase 11 9 114 ------y----l-cefghsn-jx--- Gst [O] COG0625 Glutathione-S-transferases 10 9 19 aompkz-q-----ce-----u----- HypE [O] COG0309 Hydrogenase maturation factor 7 12 13 a-m-k--q-----ce-----u----- HypD [O] COG0409 Hydrogenase maturation factor 7 12 12 a-m-k--q-----ce-----u----- HypF [O] COG0068 Hydrogenase maturation factor 24 3 82 aompkzyqvdrlbcefghsnujx-t- HflC [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs 26 1 47 aompkzyqvdrlbcefghsnujxitw QRI7 [O] COG0533 Metal-dependent proteases with possible chaperone activity 23 4 93 -omp--yqvdrlbcefghsnujxitw DnaK [O] COG0443 Molecular chaperone 19 7 52 aompkzyqvdr-bcefg-s--jx--- IbpA [O] COG0071 Molecular chaperone (small heat shock protein) 23 4 40 -omp--yqvdrlbcefghsnujxitw GrpE [O] COG0576 Molecular chaperone GrpE (heat shock protein) 13 8 24 ------y---r-bcefghs-ujx-t- HtpG [O] COG0326 Molecular chaperone, HSP90 family 23 4 115 -omp--yqvdrlbcefghsnujxitw DnaJ [O] COG0484 Molecular chaperones (contain C-terminal Zn finger domain) 13 13 26 a-m----q-dr-bcef-h--uj---w HypB [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase 18 8 37 aompk--q---lbcefghsnujx--- NrdG [O] COG0602 Organic radical activating enzymes 17 5 68 ------yqvd-lbcefghsnujx-t- SurA [O] COG0760 Parvulin-like peptidyl-prolyl isomerase 18 7 38 -om---y--drlbcefghsnuj--tw MsrA [O] COG0225 Peptide methionine sulfoxide reductase 17 8 58 -om---y--drlbcefghsnuj--t- PpiB [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family 24 3 54 aompkzyqvdrlbcefghs-ujxit- AhpC [O] COG0450 Peroxiredoxin 18 7 40 -o-p-zyqvdr-bcefghsnuj---- Bcp [O] COG1225 Peroxiredoxin 12 12 24 aompk---v---b-efgh------t- LonB [O] COG1067 Predicted ATP-dependent protease 7 12 11 -o----y------cefg----j---- ECM4 [O] COG0435 Predicted glutathione S-transferase 7 4 12 aompk-yq------------------ GIM5 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding 20 7 72 aompkzyqv-r-b-efghs-ujx-t- HslV [O] COG0638 Proteasome protease subunit 13 8 27 aom-kz--v-----efg-snuj---- Pcm [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase 17 8 37 ao-----q-dr-bcefghsnujxi-- DsbG [O] COG1651 Protein-disulfide isomerase 9 14 24 a---kzy---r--c--gh---j---- STE14 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase 13 12 38 a-mpkz-qv-rl--efgh-------- PflA [O] COG1180 Pyruvate-formate lyase-activating enzyme 17 7 68 ao---zyq-drlbc-fg-snuj---w AprE [O] COG1404 Subtilisin-like serine proteases 26 1 239 aompkzyqvdrlbcefghsnujxitw TrxA [OC] COG0526 Thiol-disulfide isomerase and thioredoxins 26 1 76 aompkzyqvdrlbcefghsnujxitw TrxB [O] COG0492 Thioredoxin reductase 14 10 29 ao----y-----bcefghs-ujxi-- - [O] COG0694 Thioredoxin-like proteins and domains 21 5 81 -om---yqvdrlbcefghsnujxit- DegQ [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain 12 10 17 -o---zyq-dr-bc-f--s--jx--- CtaA [O] COG1612 Uncharacterized protein required for cytochrome oxidase assembly 21 5 76 aompkzyq-drlbcefghsnuj---- HtpX [O] COG0501 Zn-dependent protease with chaperone function 13 11 64 ----kzy--drlbcef--s--jx--- AmpC [M] COG1680 Beta-lactamase class C and other penicillin binding proteins 9 12 21 -o--------r-b-efgh-n----t- BetT [M] COG1292 Choline-glycine betaine transporter 9 10 31 ------yq-dr---efg---uj---- Cfa [M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases 10 6 17 aompkzyq---lb------------- TagD [MI] COG0615 Cytidylyltransferase 11 13 18 a-m----q--r--cefg-s-uj---- Gmd [M] COG1089 GDP-D-mannose dehydratase 23 4 43 -ompkzyqvdrlbcefghsnuj-it- GlmS [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains 25 2 238 aompkzyqvdrlbcefghsnujx-tw WcaA [M] COG0463 Glycosyltransferases involved in cell wall biogenesis 12 14 40 a-mpk-yq---lbcef-----j---- - [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis 13 11 21 ao--k--qvd---cefg-s-uj---- CpsB [M] COG0836 Mannose-1-phosphate guanylyltransferase 22 5 162 aompk-yqvdrlbcefghsnuj--t- WcaG [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 19 8 56 aompkzyq-dr-bc-f-hsnuj--t- GCD1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylases involved in lipopolysaccharide biosynthesis/translation initiation factor eIF2B subunits 10 13 14 ao-------drlb-ef----uj---- OpuBC [M] COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) 10 6 32 ------yq------efghsnuj---- TonB [M] COG0810 Periplasmic protein TonB, links inner and outer membranes 17 9 30 aom-k--q--rlbcefghs-ujx--- Ugd [M] COG1004 Predicted UDP-glucose 6-dehydrogenase 9 10 18 ------y----lb-e-gh---j--tw CotS [M] COG0510 Predicted choline kinase involved in LPS biosynthesis 24 3 260 aompkzyqvdrlbcefghsnujx-t- RfaG [M] COG0438 Predicted glycosyltransferases 7 9 12 ------y----lb--f---nu---t- DltB [M] COG1696 Predicted membrane protein involved in D-alanine export 24 3 52 aompkz-qvdrlbcefghsnujxit- - [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1 13 9 54 -o----yq-d-lbcefghs--j---- - [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases 16 4 40 ------yqvd---cefghsnujxit- - [M] COG0729 Predicted outer membrane protein 17 8 29 a-m-kzyq----b-efghsnujxi-- GutQ [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation 10 12 19 ----k-y--d-lb-efgh-n------ LrgB [M] COG1346 Putative effector of murein hydrolase 6 7 20 aom-k---v---b------------- - [M] COG1361 S-layer domain 22 5 80 aompkz-qvdrlbcefg-snujx-t- MscS [M] COG0668 Small-conductance mechanosensitive channel 13 9 28 -o------vd--bcefghsnuj---- WcaJ [M] COG2148 Sugar transferases involved in lipopolysaccharide synthesis 16 9 22 -om-k---vd-lbcefghsnu-x--- WecB [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 21 5 56 --m-k-yqvdrlbcefghsnujxit- Rfe [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase 15 10 30 --m---yq-d-lbcefgh-nuj---w GalE [M] COG1087 UDP-glucose 4-epimerase 18 8 26 aompkz-q-drlbcef--sn-jx--- RfbD [M] COG1091 dTDP-4-dehydrorhamnose reductase 17 8 29 a-mpkzy--drlbcef-hsn-j---- RfbB [M] COG1088 dTDP-D-glucose 4,6-dehydratase 17 9 32 aompkz--vdrlbcef--sn-j---- RfbA [M] COG1209 dTDP-glucose pyrophosphorylase 8 12 20 ao--k---v---b---g---u---t- CheC [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation 14 13 30 ao--k---vd--bcefg-s-uj--t- CheA [N] COG0643 Chemotaxis protein histidine kinase and related kinases 9 15 11 ao--k---v---b--fg----j--t- CheD [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins 12 13 23 ao--k---v---b-efg-s-uj--t- CheB [NT] COG2201 Chemotaxis response regulator CheB, consists of CheY-like receiver domain and a methylesterase (demethylase) domain 13 14 53 ao--k---v---bcefg-s-uj--t- CheW [N] COG0835 Chemotaxis signal transduction protein 9 13 39 -om---y--dr---ef----uj---- BetA [N] COG2303 Choline dehydrogenase and related flavoproteins 20 2 35 ------yqvdrlbcefghsnujxitw LepA [N] COG0481 Membrane GTPase LepA 8 14 12 a--pkz-q----b--f-----j---- - [NO] COG1030 Membrane-bound serine protease (ClpP class) 14 13 207 ao--k---vd--bcefg-s-uj--t- Tar [N] COG0840 Methyl-accepting chemotaxis protein 11 14 26 ao--k---v---b-efg---uj--t- CheR [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins 23 4 56 aompkz-qvdr-bcefghsnujxit- SppA [NO] COG0616 Periplasmic serine proteases (ClpP class) 13 10 48 aompkz----r----f-hs-ujx--- VirB11 [N] COG0630 Predicted ATPases involved in pili and flagella biosynthesis, VirB11 family 20 6 35 -om-k--qvdr-bcefghsnujxit- SecD [N] COG0342 Preprotein translocase subunit SecD 20 6 32 -om-k--qvdr-bcefghsnujxit- SecF [N] COG0341 Preprotein translocase subunit SecF 26 1 46 aompkzyqvdrlbcefghsnujxitw SecY [N] COG0201 Preprotein translocase subunit SecY 20 2 40 ------yqvdrlbcefghsnujxitw YidC [N] COG0706 Preprotein translocase subunit YidC 18 7 31 ao-p-z-q-dr-bcefghsnujx--- TatC [N] COG0805 Sec-independent protein secretion pathway component TatC 18 7 51 ao-p-z-q-dr-bcefghsnujx--- TatA [N] COG1826 Sec-independent protein secretion pathway components 25 2 68 aompkzyqvdrlbcefghsnujxit- LepB [N] COG0681 Signal peptidase I 19 7 33 aom-kz-qvd-lbcefghsnuj---- PppA [N] COG1989 Signal peptidase, cleaves prepilin-like proteins 26 1 44 aompkzyqvdrlbcefghsnujxitw Ffh [N] COG0541 Signal recognition particle GTPase 26 1 46 aompkzyqvdrlbcefghsnujxitw FtsY [N] COG0552 Signal recognition particle GTPase 12 12 35 ao--kz--vd-lb--f-----j--tw Med [N] COG1744 Surface lipoprotein 13 7 23 ------yq--r--cefghs-ujxi-- CysQ [P] COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase 19 7 91 aompkz--vdrlbcefgh-nuj---- FecB [P] COG0614 ABC-type Fe3+-siderophores transport systems, periplasmic components 22 5 46 aom-kz-qvdrlbcefgh-nujxit- ZnuA [P] COG0803 ABC-type Mn/Zn transport system, periplasmic Mn/Zn-binding (lipo)protein (surface adhesin A) 21 6 41 aom-kz-qvd-lbcefgh-nujxit- ZnuC [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component 22 5 49 aom-kz-qvdrlbcefgh-nujxit- ZnuB [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components 19 7 70 aompk---vdrlbcefgh-nuj---w FepC [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components 19 7 103 aompkz--vd-lbcefgh-nuj---w BtuC [PH] COG0609 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components 16 7 51 aom-kz--vdrlbce-gh------tw CbiO [P] COG1122 ABC-type cobalt transport system, ATPase component 14 7 31 aom-kz--vdrlbce--h-------w CbiQ [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters 17 9 34 aompkz-q-dr-bcefgh--uj---- ModA [P] COG0725 ABC-type molybdate transport system, periplasmic component 12 14 49 a-mp----vd--bcef-hs--j---- TauB [P] COG1116 ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, ATPase components 12 13 62 a-----y-vd--bcefgh---j-i-- TauA [P] COG0715 ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components 13 14 50 a-mp----vd--bcef-hs--j-i-- TauC [P] COG0600 ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components 21 6 38 aom-kz-qvdrlbcefghs-uj--tw PstB [P] COG1117 ABC-type phosphate transport system, ATPase component 21 6 46 aom-kz-qvdrlbcefghs-uj--tw PstS [P] COG0226 ABC-type phosphate transport system, periplasmic component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstA [P] COG0581 ABC-type phosphate transport system, permease component 21 6 34 aom-kz-qvdrlbcefghs-uj--tw PstC [P] COG0573 ABC-type phosphate transport system, permease component 19 7 55 aompkz-q-dr-bcefghsnuj---- CysU [P] COG0555 ABC-type sulfate/molybdate transport systems, permease components 9 10 13 a---kzyq-d--bc------u----- MET3 [P] COG2046 ATP sulfurylase 15 11 23 a---kzyq-dr-bcefg-s-uj---- CysC [P] COG0529 Adenylylsulfate kinase and related kinases 9 14 14 -o--k-y-vd--b-ef--s------- PhoA [P] COG1785 Alkaline phosphatase 17 9 38 a-mp--yqvdrlbcef--sn-j---w AmtB [P] COG0004 Ammonia permeases 10 15 12 a-m-k-y-v-r-bc---h-n------ ACR3 [P] COG0798 Arsenite efflux pump ACR3 and related permeases 10 8 23 -ompkzyq--r-bc------------ ArsA [P] COG0003 Arsenite transporting ATPase 7 12 26 -o----y---r---ef-h---j---- AslA [P] COG3119 Arylsulfatase A and related enzymes 7 10 12 ------y--dr-bce------j---- ChaA [P] COG0387 Ca2+/H+ antiporter 14 9 25 aompk-yqv---bce-gh------t- ECM27 [P] COG0530 Ca2+/Na+ antiporter 16 8 36 -om---y--drlbcefghsnuj---- CynT [P] COG0288 Carbonic anhydrase 10 9 27 ------y--d--b-efgh-nuj---- KatE [P] COG0753 Catalase 10 13 15 ao----y---r-bce-g-s--j---- KatG [P] COG0376 Catalase (peroxidase I) 24 3 89 aompkzyqvdrlbcefgh-nuj-itw ZntA [P] COG2217 Cation transport ATPases 12 14 62 --mp--yq--rlbcef-----j---w MgtA [P] COG0474 Cation transport ATPases 18 8 46 aompkzyq-drlbce-gh-n-j---- EriC [P] COG0038 Chloride channel protein EriC 15 10 28 ----k-yqvdrlb-ef-hsnuj---- CzcD [P] COG1230 Co/Zn/Cd efflux system component 16 8 30 ao-p-zyqvd-lbc-f-h-nu----w CopZ [P] COG2608 Copper chaperone 10 11 20 ------yq-dr-b-e-gh-n-j---- SodC [P] COG2032 Cu/Zn superoxide dismutase 17 8 50 -om-k-yq-d-lbcefghsnu--i-- CitT [P] COG0471 Di- and tricarboxylate transporters 20 6 52 a--p-z-qvdrlbcefghsnuj--tw Fur [P] COG0735 Fe2+/Zn2+ uptake regulation proteins 12 12 51 -o-p--y-vdr-bcef--s--j---- HcaA1 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases 10 15 18 a-m-----v-r-b-e-gh--u----w Ftn [P] COG1528 Ferritin-like protein 14 12 21 a-m-k--qvd-l-cefg-s-uj---- FeoB [P] COG0370 Ferrous ion uptake system protein FeoB (predicted GTPase) 8 9 12 ------y--d----efgh-n-j---- GntK [P] COG3265 Gluconate kinase 9 12 12 -o-p-----dr--cef----uj---- KdpB [P] COG2216 High-affinity K+ transport system, ATPase chain B 13 13 21 a----zy-v---bcef-h-nu-x-t- FTR1 [P] COG0672 High-affinity iron permease 20 6 46 aom-kz-qvdrlbcefgh-nu---tw TrkA [P] COG0569 K+ transport systems, NAD-binding component 8 13 11 -o-p-----dr--cef-----j---- KdpA [P] COG2060 K+-transporting ATPase, A chain 8 13 11 -o-p-----dr--cef-----j---- KdpC [P] COG2156 K+-transporting ATPase, c chain 22 5 60 a-mpkzyq-drlbcefghsnujx-t- KefB [P] COG0475 Kef-type K+ transport systems, membrane components 24 2 79 aompkzyqvdrlbcefghsnujx--w Kch [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component 18 8 47 a-m-k-yqvdrlbcefghs-uj---- CorA [P] COG0598 Mg2+ and Co2+ transporters 11 12 25 ---p--y--drlb-ef--sn-j---- MntA [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family 10 14 20 -om-k---vd--bc-fg-----x--- MnhC [P] COG1006 Multisubunit Na+/H+ antiporter 9 14 18 -om-k---vd--b--fg-----x--- MnhE [P] COG1863 Multisubunit Na+/H+ antiporter 10 14 26 -om-k---vd--bc-fg-----x--- MnhB [P] COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit 9 14 13 -om-k---vd--b--fg-----x--- MnhF [P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit 15 12 29 a--pkz--v-r-bcefg--nuj-i-- ArsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases 17 8 39 aompk-y--drlbcefghs--j---- NhaP [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters 11 15 19 a-m-k---vd--b--fgh---j-i-- - [P] COG1392 Phosphate transport regulator (distant homolog of PhoU) 20 7 50 aompkz-qvdrlbcefg-s--j--tw PhoU [P] COG0704 Phosphate uptake regulator 18 9 50 aompk-y-vdr-b-efgh-nuj-i-- PitA [P] COG0306 Phosphate/sulphate permeases 21 6 36 aom-kzyqvdrlbcefgh--ujx-t- MMT1 [P] COG0053 Predicted Co/Zn/Cd cation transporters 14 9 23 -om-kzyqvdr---ef---nu---t- - [P] COG0428 Predicted divalent heavy-metal cations transporter 7 11 40 ------y--dr-bc-f-----j---- TrkA [P] COG2072 Predicted flavoprotein involved in K+ transport 13 13 17 a-m-k---vd-l-cefg-s-uj---- FeoA [P] COG1918 Protein, probably involved in Fe2+ transport 12 13 27 -om--zyq-dr-b-efg----j---- SseA [P] COG2897 Rhodanese-related sulfurtransferases 21 6 95 aomp--yq-drlbcefghsnujx-t- PspE [P] COG0607 Rhodanese-related sulfurtransferases 13 9 37 ------yq--rlbcefgh--uj-i-- SUL1 [P] COG0659 Sulfate permease and related transporters (MFS superfamily) 10 11 23 ------y-----bcefg-sn-j-i-- CysJ [P] COG0369 Sulfite reductase flavoprotein subunit 13 11 25 a-----yq-dr-bcefg-sn-j---- CysI [P] COG0155 Sulfite reductase hemoprotein beta-component 22 5 49 -omp-zyq-drlbcefghsnujxit- SodA [P] COG0605 Superoxide dismutase 11 13 19 a-mpk-y---rl--e-gh-n------ TehA [P] COG1275 Tellurite resistance protein and related permeases 20 6 37 aom-kzyqvd-lbcefgh-nu---tw TrkG [P] COG0168 Trk-type K+ transport systems, membrane components 12 12 15 a-mpkz-qvd----e---s---xi-- CutA [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations 6 11 40 ------y---r--c-f-----j--t- CyaA [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) 12 12 21 ----kz-q--rlb-efgh-nu----- CstA [T] COG1966 Carbon starvation protein, predicted membrane protein 20 7 334 aom-k-y-vdrlbcefghs-ujx-t- CheY [T] COG0784 CheY-like receiver domains 14 11 41 aom-kzyq-d--bc-fg--n-j---- AcuC [TQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein 20 6 79 aompkzy-vd-lbcefghsnuj---- ApaH [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases 7 10 30 ------y--dr-bc----s----i-- - [T] COG1716 FHA-domain-containing proteins 14 12 64 aom---yqvdr-bcefg----j---- FhlA [T] COG2203 GAF domain 13 9 20 -o-p--y-v--lb-efghsn-j---- - [T] COG1956 GAF domain-containing proteins 17 10 210 aom----qvdr-bcefg-s-uj-it- AtoS [T] COG2202 PAS/PAC domain 12 11 18 a----z-q--r--cefghs-uj---- SixA [T] COG2062 Phosphohistidine phosphatase SixA 14 9 43 ---p--yq-drlbc-f--s-uj-i-w PTC1 [T] COG0631 Protein serine/threonine phosphatases 6 12 12 ------y--drl---f-----j---- - [T] COG2365 Protein tyrosine/serine phosphatase 18 8 42 aom---yq-drlbcefghsnuj---- Wzb [T] COG0394 Protein-tyrosine-phosphatase 11 8 46 aompkzyqv----c-------j---- RAD55 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction 22 5 549 aom---yqvdrlbcefghsnujxit- BaeS [T] COG0642 Sensory transduction histidine kinases 18 8 297 -o-p-zyq-drlbcefghs--j-i-w SPS1 [T] COG0515 Serine/threonine protein kinases 11 8 32 -o----y------cefghsn-jx--- BolA [T] COG0271 Stress-induced morphogen (activity unknown) 20 6 116 aompkzyq-drlbcefgh-n-jx--- UspA [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins 18 4 90 ------yqvdrlbcefghsnuj-it- Crp [T] COG0664 cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 11 11 20 aom-kz--vd-lb-----s--j---- NatB [C] COG1668 ABC-type Na+ efflux pump, permease component 7 14 12 ao----y------cef-----j---- ACH1 [C] COG0427 Acetyl-CoA hydrolase 16 9 30 -o-p-zyq-drlb-efg-sn-jx--- AcnA [C] COG1048 Aconitase A 15 11 25 a-mpkz--vd-lb-efgh---j--t- AcyP [C] COG1254 Acylphosphatases 16 8 35 aompkzyqv--lb-efgh---j---- EutG [C] COG1454 Alcohol dehydrogenase IV 17 9 94 aompkz-q-dr-bcefgh--uj---- BisC [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing 11 6 23 aompkzy--d-l-----------it- NtpA [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A 11 6 18 aompkzy--d-l-----------it- NtpB [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B 8 8 13 aompk-y--d-l-------------- NtpC [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C 11 6 18 aompkzy--d-l-----------it- NtpD [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D 10 5 16 aompkzy--d-------------it- NtpE [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E 8 7 13 aompk-y--d--------------t- NtpG [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F 11 6 21 aompkzy--d-l-----------it- NtpI [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I 22 4 51 aomp-zyqvdrlbcefghsnujx--- GltA [C] COG0372 Citrate synthase 12 13 84 aom---y--drlb-ef--s--j---- - [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases 16 8 30 -o-p-zyq-dr-bc-fg-snujx--- QcrB [C] COG1290 Cytochrome b subunit of the bc complex 16 9 34 ao-p---q--rlbcefgh--ujxi-- CydA [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 14 9 28 -o-----q--rlbcefgh--ujxi-- AppB [C] COG1294 Cytochrome bd-type quinol oxidase, subunit 2 10 8 18 ------yq----b--fg-snujx--- CYT1 [C] COG2857 Cytochrome c1 16 8 56 aompkzyqv-r--cef--sn-j---- FixC [C] COG0644 Dehydrogenases (flavoproteins) 5 8 8 a-m-k---v---------------t- - [C] COG2033 Desulfoferrodoxin 19 6 77 -o-p-zy--drlbcefghsn-jxi-w AceF [C] COG0508 Dihydrolipoamide acyltransferases 23 4 97 aomp-zyqvdrlbcefghsn-jxi-w Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes 14 11 32 ao-p-zy-vdr-b-ef--sn-j---- FixB [C] COG2025 Electron transfer flavoprotein alpha-subunit 14 11 31 ao-p-zy-vdr-b-ef--sn-j---- FixA [C] COG2086 Electron transfer flavoprotein beta-subunit 17 4 29 ------yqv-rlbcefghsnujx--w AtpB [C] COG0356 F0F1-type ATP synthase a subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpA [C] COG0056 F0F1-type ATP synthase alpha subunit 17 4 31 ------yqv-rlbcefghsnujx--w AtpD [C] COG0055 F0F1-type ATP synthase beta subunit 26 1 53 aompkzyqvdrlbcefghsnujxitw AtpE [C] COG0636 F0F1-type ATP synthase c subunit/Archaeal/vacuolar-type H+-ATPase subunit K 17 4 31 ------yqv-rlbcefghsnujx--w AtpH [C] COG0712 F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) 17 4 30 ------yqv-rlbcefghsnujx--w AtpC [C] COG0355 F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) 17 4 32 ------yqv-rlbcefghsnujx--w AtpG [C] COG0224 F0F1-type ATP synthase gamma subunit 18 7 100 ao-p-zyq-dr-bcefghsnuj---- GlcD [C] COG0277 FAD/FMN-containing dehydrogenases 18 8 77 aomp-z-q-drlbcefgh-nuj---- GlpC [C] COG0247 Fe-S oxidoreductases 10 7 23 aompkzy-v----c------u----- - [C] COG0731 Fe-S oxidoreductases 15 11 54 a-mpkz--vdrlbcefg----j---- - [C] COG1032 Fe-S oxidoreductases family 2 11 10 38 ao--kz-q------efgh--uj---- HybA [C] COG0437 Fe-S-cluster-containing hydrogenase components 1 6 8 6 -o-----qvd--bc------------ - [C] COG3411 Ferredoxin 15 8 49 ao----yq-dr--cefgh-n-jxi-- Fdx [C] COG0633 Ferredoxin 10 8 16 aom-kz--v-rlbc------------ Fer [C] COG1141 Ferredoxin 1 17 9 96 a-mpkz--vd--bcefghsnuj---- NapF [C] COG1145 Ferredoxin 2 16 8 59 aompk---vdr--cefg-s-ujx--- - [C] COG1146 Ferredoxin 3 11 10 46 -o----y--dr-b-efg-sn-j---- Hmp [C] COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 13 12 38 a-m---y----lbcefghs-u---t- FldA [C] COG0716 Flavodoxins 15 11 39 aompkz--vdr-bcefg-----x--- HyfB [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit 19 5 36 aompkzyqvdr--cef--snujx--- NuoI [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) 17 7 31 -o---zy--dr-bcefghsnujxi-- FumC [C] COG0114 Fumarase 8 9 13 a---k-y-v-r---e-gh-------- GalT [C] COG1085 Galactose-1-phosphate uridylyltransferase 22 5 37 a-m---yqvdrlbcefghsnujxitw GpsA [C] COG0240 Glycerol 3-phosphate dehydrogenase 11 9 21 aompkz--v--lbce----------- GldA [C] COG0371 Glycerol dehydrogenase and related enzymes 21 6 33 ao-pkzyqvdrlbcefghs--j--tw GlpK [C] COG0554 Glycerol kinase 15 9 30 -o-p--y--drlbcefghs--j--t- GlpA [C] COG0578 Glycerol-3-phosphate dehydrogenase 17 10 50 -o-pkzy-vdrlb-efgh---j--tw UgpQ [C] COG0584 Glycerophosphoryl diester phosphodiesterase 13 11 27 -o---zyq-dr-bcef--s--jx--- CyoC [C] COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 13 11 30 -o---zyq-dr-bcef--s--jx--- CyoB [C] COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 14 11 33 ao---zyq-dr-bcef--s--jx--- CyoA [C] COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 9 10 15 ------yq-d--b-efg-s-u----- Hmp [C] COG1017 Hemoglobin-like flavoprotein 5 12 8 a-m----q-----c------u----- HdrB [C] COG2048 Heterodisulfide reductase subunit B 22 5 41 -ompkzyq-dr-bcefghsnujxi-w Ppa [C] COG0221 Inorganic pyrophosphatase 8 11 11 a-m---y-vd-lb---g--------- PPX1 [C] COG1227 Inorganic pyrophosphatase/exopolyphosphatase 17 8 28 ao-p-zyqvdrlbcef-h--uj---- Icd [C] COG0538 Isocitrate dehydrogenases 8 12 15 ------y--dr-b-efg----j---- AceA [C] COG2224 Isocitrate lyase 20 6 44 aompkzy--drlbcefgh-n-jx-t- LldD [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases 11 11 25 ao-------d--b-efgh-nu---t- LldP [C] COG1620 L-lactate permease 16 11 57 ---pkzyq---lbcefgh-nuj--t- LdhA [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases 8 12 16 ------y--dr-b-efg----j---- AceB [C] COG2225 Malate synthase 23 4 45 aomp-zyqvdrlbce-ghs-ujxitw Mdh [C] COG0039 Malate/lactate dehydrogenases 21 5 42 ao-pkzy-vdrlbcefghsnujx--- SfcA [C] COG0281 Malic enzyme 19 7 202 -omp-zyq-drlbcefgh-nuj---w PutA [C] COG1012 NAD-dependent aldehyde dehydrogenases 12 9 28 -o----y--drlbcefgh---j---- Ndh [C] COG1252 NADH dehydrogenase, FAD-containing subunit 13 6 21 ------yqvdr--cef--snujx--- NuoG [C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) 14 10 54 ao-p--y-vdrlb-efg-s--j---- NemA [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family 18 6 26 ao-pkzyqvdr--cef--snujx--- NuoB [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 13 10 21 --m---yqvdr--cef--sn-jx--- NuoE [C] COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoC [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 18 6 27 ao-pkzyqvdr--cef--snujx--- NuoD [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 15 8 24 ao-p-z-q-dr--cef--snujx--- NuoH [C] COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H) 14 9 22 -o-p-z-q-dr--cef--snujx--- NuoK [C] COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) 15 8 23 ao-p-z-q-dr--cef--snujx--- NuoN [C] COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N) 13 9 22 -o-p---q-dr--cef--snujx--- NuoA [C] COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A) 13 9 24 -o-p---q-dr--cef--snujx--- NuoM [C] COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M) 18 8 38 ao-pkz-q-dr-bcefg-snujx--- NuoL [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit 15 8 26 ao-p-z-q-dr--cef--snujx--- NuoJ [C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) 13 10 21 --m---yqvdr--cef--sn-jx--- NuoF [C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit 15 10 84 -o-p-zyq-drlb-efghs--j---- Qor [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases 7 14 10 a---k---v--l----gh------t- OadB [C] COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit 9 13 28 -o--kz------b---gh-nu---t- NhaC [C] COG1757 Na+/H+ antiporter 16 10 39 -o--kz-q-dr-b-efg-s-ujxit- GltP [C] COG1301 Na+/H+-dicarboxylate symporters 5 11 12 a-m----q------e-----u----- HyaB [C] COG0374 Ni,Fe-hydrogenase I large subunit 7 12 22 a-m-k--q-----ce-----u----- HyaD [C] COG0680 Ni,Fe-hydrogenase maturation factor 19 6 37 ao----yqv-rlb-efgh-nujxitw IscU [C] COG0822 NifU homologs involved in Fe-S cluster formation 21 5 89 aompkz-qvdrlbcefghsnuj---- NfnB [C] COG0778 Nitroreductase 10 12 14 -----zy--d--b-efgh--uj---- PckA [C] COG1866 Phosphoenolpyruvate carboxykinase (ATP) 18 5 40 -o------vdrlbcefghsnujx-tw Pta [C] COG0280 Phosphotransacetylase 10 15 24 -om---y-----bcef-----j-it- - [C] COG1413 Phycocyanin alpha-subunit phycocyanobilin lyase and related proteins 4 7 8 a-m----qv----------------- - [C] COG1148 Polyferredoxins 6 12 8 ----kzy-v---b--------j---- - [C] COG2421 Predicted acetamidase/formamidase 8 13 33 a--p--y--dr---ef-----j---- CaiB [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase 18 8 94 -o-p-zyqvdrlbcefg-s-uj--t- Tas [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) 13 8 24 ------y--dr-b-efghsn-jxi-- SucA [C] COG0567 Pyruvate and 2-oxoglutarate dehydrogenases, E1 component 11 13 18 a-m-k-yq--rlb--f----uj---- PycA [C] COG1038 Pyruvate carboxylase, C-terminal domain/subunit 18 9 63 aompkzyqv-rlbce-g---uj--t- PorA [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit 18 9 60 aompkzyqv-rlbce-g---uj--t- PorB [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit 7 7 15 a-mpk--qv-----------u----- - [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit 17 10 55 aompkz-qv-rlbce-g---uj--t- PorG [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit 16 8 35 -o-p-zyq-dr-bc-fg-snujx--- QcrA [C] COG0723 Rieske Fe-S protein 12 13 21 a-m-k---v-r--cef--sn-j--t- - [C] COG1773 Rubredoxin 6 11 14 a-m-k---v---b-------u----- - [C] COG1592 Rubrerythrin 13 10 18 a--p-z---dr---efg-sn-jxi-- SdhD [C] COG2142 Succinate dehydrogenase hydrophobic anchor subunit 21 6 41 aomp-zyq-dr-bcefghsnujxi-- FrdB [C] COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein 17 8 28 ao-p-zy--dr-b-efg-snujxi-- SdhC [C] COG2009 Succinate dehydrogenase/fumarate reductase cytochrome b subunit 23 4 54 aomp-zyqvdrlbcefghsnujxi-- SdhA [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunits 21 6 38 aomp-zyq-dr-bcefghsnujxi-- SucD [C] COG0074 Succinyl-CoA synthetase alpha subunit 21 6 34 aomp-zyq-dr-bcefghsnujxi-- SucC [C] COG0045 Succinyl-CoA synthetase beta subunit 12 12 22 a-m-k--qv---b-efg-sn-j---- TtdA [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain 12 12 23 a-m-k--qv---b-efg-sn-j---- FumA [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain 14 9 35 -o-p-zy--drlbc-f-----jxi-w AcoA [C] COG1071 Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunit 14 9 33 -o-p-zy--drlbc-f-----jxi-w AcoB [C] COG0022 Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunit 6 5 7 aom-kz--v----------------- - [C] COG1031 Uncharacterized Fe-S oxidoreductases 12 11 19 aomp-z---d-lb-e--h-nu----- - [C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain 8 10 22 a-m-k--qv----cef---------- - [C] COG0426 Uncharacterized flavoproteins 9 11 19 ------y---r-bcef-h-n-j---- AdhC [C] COG1062 Zn-dependent alcohol dehydrogenases, class III 12 10 20 ------yq-dr-bcefgh---j-i-- GlgB [G] COG0296 1,4-alpha-glucan branching enzyme 25 2 43 aompkzyqvdrlbcefghsnuj-itw Pgk [G] COG0126 3-phosphoglycerate kinase 16 6 35 ------yqvdrlbce-ghs--j-itw PfkA [G] COG0205 6-phosphofructokinase 13 9 23 ------y-v-rlbce-gh-n-j-it- Gnd [G] COG0362 6-phosphogluconate dehydrogenase, family 1 7 10 8 -o-----q-drlb--------j---- Gnd [G] COG1023 6-phosphogluconate dehydrogenase, family 2 16 6 42 ------y-v-rlbcefghsnuj-it- NagB [G] COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase 15 11 95 ao--kz--vd-lb-efgh---j--tw MglA [G] COG1129 ABC-type sugar (aldose) transport system, ATPase component 18 9 110 -o-pkz--vdrlbcefghs--j--tw MalF [G] COG1175 ABC-type sugar transport systems, permease components 23 4 175 aompkz-qvdrlbcefghsnuj--tw MalK [G] COG1130 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component 6 11 10 --mpk--q-----c----------t- - [G] COG1449 Alpha-amylase/alpha-mannosidase 7 12 18 ---p--y-v--lb-e------j---- - [G] COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases 9 11 14 ---pk-y-v-rlbce----------- AMS1 [G] COG0383 Alpha-mannosidase 23 4 48 aom-kzyqvdrlbcefghsnujx-t- SuhB [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family 7 8 10 ------y-v--lb-e-gh-------- SacC [G] COG1621 Beta-fructosidases (levanase/invertase) 6 12 14 ------y-v--lb-e---s------- LacZ [G] COG3250 Beta-galactosidase/beta-glucuronidase 5 11 20 ------y-v-r-b--------j---- SKN1 [G] COG2273 Beta-glucanase/Beta-glucan synthetase 16 6 41 ------y-vdrlbcefghsn-jx-t- BglX [G] COG1472 Beta-glucosidase-related glycosidases 12 12 33 aom-kz--vd-lb-ef---------w FrvX [G] COG1363 Cellulase M and related proteins 10 13 22 -o---z---drl--efgh---j---- CitE [G] COG2301 Citrate lyase beta subunit 10 12 19 aom-kz-q------e--h---j-i-- FbaB [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes 7 12 23 ------y--d-lb-e--h---j---- DAK1 [G] COG2376 Dihydroxyacetone kinase 5 9 17 ----k-y-v---b-----s------- BglC [G] COG2730 Endoglucanase 25 2 51 aompkzyqvdrlbcefghsnuj-itw Eno [G] COG0148 Enolase 10 9 16 -o----y------cefgh-nuj---- Fbp [G] COG0158 Fructose-1,6-biphosphatase 17 5 42 ------yqvdrlbcefgh-nuj--tw Fba [G] COG0191 Fructose/tagatose bisphosphate aldolase 8 10 16 ------y-----b-e--hsnuj---- FucP [G] COG0738 Fucose permease 10 12 15 ----k-y-v-rlb-e-gh------t- GalK [G] COG0153 Galactokinase 11 12 29 ---p--y-vd-lb-e-gh-n-j---- GalM [G] COG2017 Galactose mutarotase and related enzymes 15 11 25 --m-k-yq-drlbcefgh---j-i-- GlgP [G] COG0058 Glucan phosphorylase 8 14 21 ---p--y--d--b--f-hs--j---- - [G] COG3386 Gluconolactonase 18 4 31 ------yqvdrlbcefghsnuj-it- Zwf [G] COG0364 Glucose-6-phosphate 1-dehydrogenase 23 4 41 -omp-zyqvdrlbcefghsnuj-itw Pgi [G] COG0166 Glucose-6-phosphate isomerase 25 2 61 aompkzyqvdrlbcefghsnuj-itw GapA [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase 15 12 36 a-m---y-vd-lbcef-hs--j--tw GlpF [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) 6 13 14 ---pk-y--d--b--------j---- GDB1 [G] COG3408 Glycogen debranching enzyme 12 12 74 ---p--y-vdrlbcefg----j---- AmyA [G] COG0366 Glycosidases 10 14 27 --m---y--dr-bcefg----j---- - [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase 9 12 19 ---pkz--vd-lb-e-g--------- MalE [G] COG2182 Maltose-binding periplasmic proteins/domains 10 9 28 ------y-v--lb-efgh---j---w MtlD [G] COG0246 Mannitol-1-phosphate/altronate dehydrogenases 16 10 39 aom-k--qv-r-bcefg-snuj---- CpsB [G] COG0662 Mannose-6-phosphate isomerase 13 9 23 ------y-vdrlb-efghs--j--t- NagA [G] COG1820 N-acetylglucosamine-6-phosphate deacetylase 21 6 40 --mp--yqvdrlbcefghsnuj-itw Rpe [G] COG0036 Pentose-5-phosphate-3-epimerase 24 3 215 aompkzyqvd-lbcefghsnujxit- RhaT [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily 26 1 925 aompkzyqvdrlbcefghsnujxitw ProP [GEPR]COG0477 Permeases of the major facilitator superfamily 21 6 43 aompkz-qvdr-bcefg-snujx-t- PpsA [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase 7 11 11 ------y--dr--ce-g----j---- Pgm [G] COG0033 Phosphoglucomutase 10 11 23 ------y---rl--e--hsn-j-it- GpmA [G] COG0588 Phosphoglycerate mutase 1 15 9 75 ---p--yqvdrlbcefghs--j---- GpmB [G] COG0406 Phosphoglycerate mutase/fructose-2,6-bisphosphatase 12 12 25 --mp---q--r--cefgh-nuj---- GmhA [G] COG0279 Phosphoheptose isomerase 26 1 94 aompkzyqvdrlbcefghsnujxitw CpsG [G] COG1109 Phosphomannomutase 11 10 20 a-----y-vdrlb-e-gh------t- ManA [G] COG1482 Phosphomannose isomerase 5 5 8 ----kzyqv----------------- - [G] COG2152 Predicted glycosylase 8 7 14 a-mpkz-qvd---------------- - [G] COG3635 Predicted phosphoglycerate mutase, AP superfamily 21 5 32 aompkzyqvdrlbcefg-snuj---- - [G] COG0063 Predicted sugar kinase 15 11 30 ao--kzyqv-rlb-ef----ujx--- NagD [G] COG0647 Predicted sugar phosphatases of the HAD superfamily 15 11 53 ---pk-y-vdrlbcefg-s-uj---- CDA1 [G] COG0726 Predicted xylanase/chitin deacetylase 5 12 6 ------y---rl------s--j---- - [G] COG3537 Putative alpha-1,2-mannosidase 7 14 9 ---pkz--vd-----f-----j---- GckA [G] COG2379 Putative glycerate kinase 23 4 53 -ompkzy-vdrlbcefghsnuj-itw PykF [G] COG0469 Pyruvate kinase 19 7 31 aompkzy--d-l-cefghsn-j-it- RpiA [G] COG0120 Ribose 5-phosphate isomerase 21 5 50 aompkzyqv-rlb-efghs-ujx--w AraD [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases 13 13 48 a----zy-v-rlbcef-h---j--t- XylB [G] COG1070 Sugar (pentulose and hexulose) kinases 13 13 16 a-mp-z-qv---bcefgh---j---- SfsA [G] COG1489 Sugar fermentation stimulation protein (uncharacterized) 19 7 112 aompkzy-vdrlbcefghs--j---- RbsK [G] COG0524 Sugar kinases, ribokinase family 18 9 111 -o-pkz--vdrlbcefghs--j--tw MalG [G] COG0395 Sugar permeases 10 16 51 a-m-k---v-r-bcef-----j---- IolE [G] COG1082 Sugar phosphate isomerases/epimerases 17 10 83 -o-pkz--vdrlbcefghs--j--t- UgpB [G] COG1653 Sugar-binding periplasmic proteins/domains 18 9 40 --mp--yqvdrlbcefgh-nuj-i-- MipB [G] COG0176 Transaldolase 23 4 57 --mpkzyqvdrlbcefghsnuj-itw TktA [G] COG0021 Transketolase 7 16 14 ----k-y---rlb-e----n------ ATH1 [G] COG1554 Trehalose and maltose hydrolases (possible phosphorylases) 25 2 45 aompkzyqvdrlbcefghsnuj-itw TpiA [G] COG0149 Triosephosphate isomerase 9 11 16 ------y----l-cefghs--j---- - [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase 17 8 49 -ompkzy--drlbcefg-sn-j---- CysH [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes 10 9 26 ------y--d-l--efghsn-j---- AroG [E] COG0722 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase 10 12 13 ---pkz--vd-lbc-----n---i-- AroA [E] COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase 12 12 19 aompk-yq---lb-e----n---i-- AroD [E] COG0710 3-dehydroquinate dehydratase 13 8 21 ------y-vdr-bcefghs-uj---- AroQ [E] COG0757 3-dehydroquinate dehydratase II 19 8 32 ---pkzy-vdrlbcefghsnuj-i-- AroB [E] COG0337 3-dehydroquinate synthetase 20 6 36 aom-k-yqvdrlbcefghsnuj---- LeuC [E] COG0065 3-isopropylmalate dehydratase large subunit 19 7 35 a-m-k-yqvdrlbcefghsnuj---- LeuD [E] COG0066 3-isopropylmalate dehydratase small subunit 18 8 30 ---pkzyqvd-lbcefghsnuj---- MetF [E] COG0685 5,10-methylenetetrahydrofolate reductase 23 4 39 aompkzyqvdrlbcefghsnuj-i-- AroA [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase 18 8 136 a----z--vdrlbcefgh-nujxit- ArtI [E] COG0834 ABC-type amino acid transport system, periplasmic component 16 10 117 a----z--vd-lbcefgh-nujxi-- ArtM [E] COG0765 ABC-type amino acid transport system, permease component 11 15 30 a-m--z--vd--bcef----uj---- LivF [E] COG0410 ABC-type branched-chain amino acid transport systems, ATPase component 11 15 30 a-m--z--vd--bcef----uj---- LivG [E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component 12 14 40 aom--z--vd--bcef----uj---- LivK [E] COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component 19 7 91 ao-pkz-qvd-lb-efgh--uj-itw OppF [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 19 7 87 ao-pkz-qvd-lb-efgh--uj-itw DppD [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 21 6 173 ao-pkz-qvdrlbcefgh--uj-itw OppA [EP] COG0747 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components 21 6 125 ao-pkz-qvdrlbcefgh--uj-itw DppB [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 21 6 124 ao-pkz-qvdrlbcefgh--uj-itw DppC [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 16 10 67 a----z--vd-lbcefgh-nujxi-- GlnQ [E] COG1126 ABC-type polar amino acid transport system, ATPase component 15 10 51 ao---z--vd-l--efgh-nuj--tw PotB [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I 15 10 51 ao---z--vd-l--efgh-nuj--tw PotC [E] COG1177 ABC-type spermidine/putrescine transport system, permease component II 19 7 29 aom---yqvdrlbcefghsnuj---- HisG [E] COG0040 ATP phosphoribosyltransferase (histidine biosynthesis) 20 6 37 a-m-kzyqvdrlbcefghsnuj---- IlvH [E] COG0440 Acetolactate synthase, small subunit 20 6 38 a-m-kzyqvdrlbcefghsnuj---- ArgB [E] COG0548 Acetylglutamate kinase 20 6 30 a-m-kzyqvdrlbcefghsnuj---- ArgC [E] COG0002 Acetylglutamate semialdehyde dehydrogenase 22 5 108 a-mpkzyqvdrlb-efghsnujxi-- ArgE [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases 9 10 16 ------y--drlbc--g---uj---- Ald [E] COG0686 Alanine dehydrogenase 12 12 20 ----k-y--dr-b-efgh-nuj---- DUR1 [E] COG2049 Allophanate hydrolase subunit 1 12 12 20 ----k-y--dr-b-efgh-nuj---- DUR1 [E] COG1984 Allophanate hydrolase subunit 2 8 7 57 ------y-------efgh-nu--i-- SdaC [E] COG0814 Amino acid permeases 6 11 64 ------y----lb-ef----u----- LysP [E] COG0833 Amino acid transporters 19 7 170 aomp-zy---rlbcefghs--jxi-w PotE [E] COG0531 Amino acid transporters 13 10 31 ---p--y--drl-cefghsn-j---- PepN [E] COG0308 Aminopeptidase N 22 4 41 aompkzyqvdrlbcefghsnuj---- TrpD [E] COG0547 Anthranilate phosphoribosyltransferase 22 4 69 aompkzyqvdrlbcefghsnuj---- TrpE [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I 22 4 51 aompkzyqvdrlbcefghsnuj---- PabA [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II 19 6 51 aompkzy--d-lbcefghsnuj---- SpeB [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family 9 14 13 -o-p------rl---fg----j--tw ArcA [E] COG2235 Arginine deiminase 20 6 31 aomp--yqvdrlbcefghsnuj---- ArgH [E] COG0165 Argininosuccinate lyase 20 6 30 aomp--yqvdrlbcefghsnuj---- ArgG [E] COG0137 Argininosuccinate synthase 15 10 38 aompkzy---rlb-efg-s--j---- AsnB [E] COG0367 Asparagine synthase (glutamine-hydrolyzing) 24 3 44 aompkzyqvdrlbcefghsnujxi-- Asd [E] COG0136 Aspartate-semialdehyde dehydrogenase 9 7 24 ------y-------efghsn-j-i-- TyrB [E] COG1448 Aspartate/aromatic aminotransferase 24 3 56 aompkzyqvdrlbcefghsnujxi-- LysC [E] COG0527 Aspartokinases 5 9 11 ------y-v-r----f--------t- LAP4 [E] COG1362 Aspartyl aminopeptidase 14 12 67 a-m--z--vd-lbcefg---ujx--- LivM [E] COG0559 Branched-chain amino acid ABC-type transport system, permease components 20 6 66 aom---yqvdrlbcefghsnujx--- IlvE [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase 20 6 41 aomp--yqvdrlbcefghsnuj---- CarB [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) 20 6 36 aomp--yqvdrlbcefghsnuj---- CarA [EF] COG0505 Carbamoylphosphate synthase small subunit 4 10 13 ------y--d--------s--j---- - [E] COG2939 Carboxypeptidase C (cathepsin A) 20 6 43 aomp-zyqvdrlb-efghsnuj---- PheA [E] COG1605 Chorismate mutase 23 4 38 aompkzyqvdrlbcefghsnuj-i-- AroC [E] COG0082 Chorismate synthase 19 7 72 -o-pkzy-vdrlbcefghsnuj---- MetC [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases 20 5 52 ao----yqvdrlbcefgh-nujxit- NifS [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes 20 6 63 -o-pkzyqvdrlbcefghsnuj---- CysK [E] COG0031 Cysteine synthase 19 7 45 a-mp--yqvdrlbcefghsnuj---- LysA [E] COG0019 Diaminopimelate decarboxylase 17 10 28 a-m----qv-r-bcefghsnujxi-- DapF [E] COG0253 Diaminopimelate epimerase 18 9 29 a-m----qv-rlbcefghsnujxi-- DapB [E] COG0289 Dihydrodipicolinate reductase 22 5 57 aompkz-qv-rlbcefghsnujxi-- DapA [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase 20 6 49 a-m-kzyqvdrlbcefghsnuj---- IlvD [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase 8 10 18 ------y----lb-e-g-sn-j---- PTR2 [E] COG3104 Dipeptide/tripeptide permease 13 13 35 -o-pkzy-vd--bc-f-hs--j---- DAP2 [E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases 17 5 26 ------yqvdrlbcefghsnuj--t- ProA [E] COG0014 Gamma-glutamyl phosphate reductase 14 10 31 ---p-zy--dr-bcefg-snuj---- Ggt [E] COG0405 Gamma-glutamyltranspeptidase 17 5 28 ------yqvdrlbcefghsnuj--t- ProB [E] COG0263 Glutamate 5-kinase 14 11 35 aom-kzy---rlbce-gh---j---- GadB [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins 17 10 44 ao-pkzy-vd--bcef-h-nuj-i-- GdhA [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase 16 10 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0067 Glutamate synthase domain 1 16 10 30 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0069 Glutamate synthase domain 2 16 10 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0070 Glutamate synthase domain 3 19 7 30 aom---yqvdrlbcefghsnuj---- HisH [E] COG0118 Glutamine amidotransferase 23 3 64 aompkzyqvdrlbcefghsnujx--- GlnA [E] COG0174 Glutamine synthase 19 8 34 -o-pkzyqvdrlbcefg-sn-j-i-- GcvH [E] COG0509 Glycine cleavage system H protein (lipoate-binding) 16 10 48 -o-pkzyqvdr-bcef--sn-j---- GcvT [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase) 16 10 25 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain 16 10 24 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain 26 1 53 aompkzyqvdrlbcefghsnujxitw GlyA [E] COG0112 Glycine hydroxymethyltransferase 21 6 120 ao-pkzyq--rlbcefghsnuj-it- DadA [E] COG0665 Glycine/D-amino acid oxidases (deaminating) 8 13 15 -o-p-----d-lb--fg----j---- HutH [E] COG2986 Histidine ammonia-lyase 19 7 31 aom---yqvdrlbcefghsnuj---- HisD [E] COG0141 Histidinol dehydrogenase 13 9 24 a-mpk-yqvdrlb-e-g--------- HIS2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family 22 4 54 aompkzyqvdrlbcefghsnuj---- HisC [E] COG0079 Histidinol-phosphate aminotransferase/Tyrosine aminotransferase 6 11 10 ------y---r-bce------j---- MHT1 [E] COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) 10 12 18 -om---y--dr----f-hsn-j---- MET2 [E] COG2021 Homoserine acetyltransferase 22 4 43 aompkzyqvdrlbcefghsnuj---- ThrA [E] COG0460 Homoserine dehydrogenase 19 7 30 -ompkzyqvdrlbce-ghs-uj---- ThrB [E] COG0083 Homoserine kinase 19 7 28 aom---yqvdrlbcefghsnuj---- HisB [E] COG0131 Imidazoleglycerol-phosphate dehydratase 19 7 30 aom---yqvdrlbcefghsnuj---- HisF [E] COG0107 Imidazoleglycerol-phosphate synthase 22 4 34 aompkzyqvdrlbcefghsnuj---- TrpC [E] COG0134 Indole-3-glycerol phosphate synthase 20 6 46 a-m-k-yqvdrlbcefghsnujx--- LeuB [E] COG0473 Isocitrate/isopropylmalate dehydrogenase 19 7 58 a-mpk-yqvdr-bcefghsnuj---- LeuA [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases 19 7 31 a-m-k-yqvdrlbcefghsnuj---- IlvC [EH] COG0059 Ketol-acid reductoisomerase 18 6 41 aompkzy--drlb-efghsnu----- AnsB [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D 19 6 130 aom-kzy--drlbcefghsnuj---- GloA [E] COG0346 Lactoylglutathione lyase and related lyases 8 12 16 -o--kz-q-d--b--------j--t- AmpS [E] COG2309 Leucyl aminopeptidase (aminopeptidase T) 10 10 27 ------y---rlbcefg--n-j---- TesA [E] COG2755 Lysophospholipase L1 and related esterases 12 14 19 a-m-----vdr-bcefgh---j---- MetH [E] COG1410 Methionine synthase I, cobalamin-binding domain 20 7 40 a-mpkzyqv-rlb-efghsnuj-i-- MetE [E] COG0620 Methionine synthase II (cobalamin-independent) 11 10 22 a-mp-zyq--r-bc------uj---- HyuA [E] COG0145 N-methylhydaintoinase A 9 10 17 --mp-zyq--r--c------uj---- HyuB [E] COG0146 N-methylhydaintoinase B 19 8 48 ---pkzyqvdrlbcefg-s-ujx-t- GltD [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases 22 5 79 aompkzyq-d--bcefghsnujxit- PutP [EHR] COG0591 Na+/proline, Na+/panthothenate symporters and related permeases 16 10 35 a-m----qvdrlbcefghsn-j---- GlnK [E] COG0347 Nitrogen regulatory protein PII 11 11 12 -o----y-vdrlb--f-h--uj---- MET17 [E] COG2873 O-acetylhomoserine sulfhydrylase 10 7 26 -o------vd-lb-------uj-itw - [E] COG1164 Oligoendopeptidase F 24 3 42 aompkzyqvdrlbcefghsnuj--tw ArgF [E] COG0078 Ornithine carbamoyltransferase 22 4 87 aompkzyqvdrlbcefghsnuj---- ArgD [E] COG0160 PLP-dependent aminotransferases 25 2 123 aompkzyqvdrlbcefghsnujxit- AvtA [E] COG0436 PLP-dependent aminotransferases 21 5 61 aompkzyqvdrlbcefghs-uj---- SerA [E] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases 19 7 28 aom---yqvdrlbcefghsnuj---- HisI [E] COG0139 Phosphoribosyl-AMP cyclohydrolase 18 7 27 -om---yqvdrlbcefghsnuj---- HisI [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase 22 5 33 aompkzyqvd-lbcefghsnuj-i-- TrpF [E] COG0135 Phosphoribosylanthranilate isomerase 19 7 28 aom---yqvdrlbcefghsnuj---- HisA [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 17 8 48 aompkzy---rl--efghsnuj---- SerB [E] COG0560 Phosphoserine phosphatase 7 13 14 ------y-----bcef---n-j---- - [E] COG2866 Predicted carboxypeptidase 20 6 31 aomp--yqvdrlbcefghsnuj---- PheA [E] COG0077 Prephenate dehydratase 21 5 32 aomp-zyqvdrlbcefghsnuj---- TyrA [E] COG0287 Prephenate dehydrogenase 12 9 22 -o----y--dr-bcef-h-nuj---- PutA [E] COG0506 Proline dehydrogenase 10 12 16 ao-pkz---dr-b-e------j---- ArgK [E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family 15 11 67 a-mp-z--vd--bcefghs-uj---- RhtB [E] COG1280 Putative threonine efflux protein 20 7 37 --mp-zyqvdrlbcefghsnuj--t- ProC [E] COG0345 Pyrroline-5-carboxylate reductase 11 12 19 a-mpkz-qv---b-ef--s------- SpeD [E] COG1586 S-adenosylmethionine decarboxylase 12 13 18 a--pkzy--d--bc--gh--uj---- LYS9 [E] COG1748 Saccharopine dehydrogenase and related proteins 21 5 54 -om-kzy-vdrlbcefghs-uj-itw CsdB [E] COG0520 Selenocysteine lyase 8 13 13 --mp---q------ef-h--uj---- SelA [E] COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase] 13 9 29 -o------v-rlbcefgh-nuj---- CysE [E] COG1045 Serine acetyltransferase 17 8 30 aompkzyqvd-lbc-fg---uj---- - [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase 23 4 45 aompkzyqvdrlbcefghsnuj-i-- AroE [E] COG0169 Shikimate 5-dehydrogenase 17 5 33 ------yqvdrlbcefghsnuj-i-- AroK [E] COG0703 Shikimate kinase 17 9 33 a-mpkzyqvdr-b-ef--snuj---- SpeE [E] COG0421 Spermidine synthase 14 12 69 ao---z--vd-l-cefgh-n-j--t- PotD [E] COG0687 Spermidine/putrescine-binding periplasmic protein 21 5 103 a-mpkzyqvdrlbcefghsnuj---- IlvB [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] 9 12 16 -o----y-vd--b-efg----j---- GLY1 [E] COG2008 Threonine aldolase 19 6 47 -o-p-zy-vdrlbcefghsnujx--- IlvA [E] COG1171 Threonine dehydratase 19 7 88 ao-pkzy-vdrlb-efghsn-j---w Tdh [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 22 4 48 aompkzyqvdrlbcefghsnuj---- ThrC [E] COG0498 Threonine synthase 13 13 44 a-m-k--qvdr-bc-f-hs--j---- - [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases 23 4 35 aompkzyqvdrlbcefghsnuj-i-- TrpA [E] COG0159 Tryptophan synthase alpha chain 21 6 32 aom-k-yqvdrlbcefghsnuj-i-- TrpB [E] COG0133 Tryptophan synthase beta chain 8 13 11 -o-p-----d-lb--fg----j---- HutU [E] COG2987 Urocanate hydratase 26 1 84 aompkzyqvdrlbcefghsnujxitw PepP [E] COG0006 Xaa-Pro aminopeptidase 7 15 9 -o--kz---d--b---g----j---- - [E] COG2317 Zn-dependent carboxypeptidases 10 8 21 ------y--d---cefghsn-j---- Dcp [E] COG0339 Zn-dependent oligopeptidases 16 11 41 aom---yqvd-lbce-gh--uj--t- UshA [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases 12 11 27 a-m-kz-q-dr--c-fg--n-j---- - [F] COG1051 ADP-ribose pyrophosphatase 19 5 29 ao-p--yqvdrlbcefghsnuj---- PurH [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 7 15 12 a-m------d--b-e------j--t- AdeC [F] COG1001 Adenine deaminase 20 6 55 -om-kzy-vdrlbcefgh-nuj--tw Apt [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins 8 12 14 ------y---rlb-efg----j---- Ada [F] COG2169 Adenosine deaminase 8 13 13 ------y---rl--efg----j--t- Add [F] COG1816 Adenosine deaminase 23 4 57 ao--k-yqvdrlbcefghsnujxitw Adk [F] COG0563 Adenylate kinase and related kinases 21 5 42 aompk-yqvdrlbcefghsnuj---- PurB [F] COG0015 Adenylosuccinate lyase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurA [F] COG0104 Adenylosuccinate synthase 10 10 16 aompkz--v-----e-g--n------ PyrI [F] COG1781 Aspartate carbamoyltransferase regulatory subunit 21 5 34 aompkzyqvdrlbcefg-snuj---- PyrB [F] COG0540 Aspartate carbamoyltransferase, catalytic chain 26 1 44 aompkzyqvdrlbcefghsnujxitw PyrG [F] COG0504 CTP synthase (UTP-ammonia lyase) 14 11 22 -o---zy-vdrlb-e-gh---j--tw Cdd [F] COG0295 Cytidine deaminase 18 8 53 aompkzyqvd--bcef-hs-uj---- SsnA [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases 16 6 36 ------yq-drlbcefghsn-jxi-- - [FJ] COG0590 Cytosine/adenosine deaminases 6 15 17 -----zy-----b-ef-----j---- FUI1 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases 5 9 8 ------y--------f----uj--t- NUC1 [F] COG1864 DNA/RNA endonuclease G, NUC1 19 8 35 aompkz-q--r-bcef-hsnujxi-- Dcd [F] COG0717 Deoxycytidine deaminase 10 10 16 a--pk-y-vd-lb---g-------t- ComEB [F] COG2131 Deoxycytidylate deaminase 17 10 25 -omp-z-qvdrlbce-gh---j--tw DeoC [F] COG0274 Deoxyribose-phosphate aldolase 25 2 74 aompkzyq-drlbcefghsnujxitw Hit [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases 7 10 13 ------y------cefg--nu----- PyrC [F] COG0418 Dihydroorotase 19 7 44 aompkzyqvdrlbcef--s-uj---- PyrC [F] COG0044 Dihydroorotase 22 4 42 aompkzyqvdrlbcefghsnuj---- PyrD [F] COG0167 Dihydroorotate dehydrogenase 16 5 31 ------yqvdr-bcefghsnujx--- GppA [FP] COG0248 Exopolyphosphatase 18 6 29 -o-p--yqvdrlbcefghsnuj---- PurN [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN 13 9 19 -o-----q-dr-bcefghs-uj---- PurU [F] COG0788 Formyltetrahydrofolate hydrolase 8 13 15 ---p--y-v--l----g--n-j---w MIS1 [F] COG2759 Formyltetrahydrofolate synthetase 24 3 52 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0518 GMP synthase - Glutamine amidotransferase domain 24 3 37 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0519 GMP synthase - PP-ATPase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurF [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase 19 3 39 ------yqvdrlbcefghsnujxi-w Gmk [F] COG0194 Guanylate kinase 23 4 90 -ompkzyqvdrlbcefghsnuj-it- GuaB [F] COG0516 IMP dehydrogenase/GMP reductase 9 11 18 ------y--dr-b-ef-h--uj---- URH1 [F] COG1957 Inosine-uridine nucleoside N-ribohydrolase 23 4 38 aompkzyq-dr-bcefghsnujxit- Ndk [F] COG0105 Nucleoside diphosphate kinase 8 10 21 ------y----lb-e-gh--uj---- NupC [F] COG1972 Nucleoside permease 23 4 40 aompkzyqvdrlbcefghsnuj-i-- PyrE [F] COG0461 Orotate phosphoribosyltransferase 22 4 36 aompkzyqvdrlbcefghsnuj---- PyrF [F] COG0284 Orotidine-5'-phosphate decarboxylase 21 5 35 aompk-yqvdrlbcefghsnuj---- PurD [F] COG0151 Phosphoribosylamine-glycine ligase 21 5 33 aompk-yqvdrlbcefghsnuj---- PurM [F] COG0150 Phosphoribosylaminoimidazol (AIR) synthetase 17 7 26 -o-p--yqvdrlbcefghsn-j---- PurK [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 22 4 35 aompk-yqvdrlbcefghsnujx--- PurC [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase 21 5 32 aompk-yqvdrlbcefghsnuj---- PurE [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase 14 7 19 aompk--qvdrlbc------uj---- PurS [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain 21 5 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain 24 3 52 aompkzyqvdrlbcefghsnuj--tw PrsA [FE] COG0462 Phosphoribosylpyrophosphate synthetase 12 8 19 -o-pkz-qv-r--c------u-xit- THY1 [F] COG1351 Predicted alternative thymidylate synthase 16 10 31 a-mpkzyqv-rlbcef--s--j---- Pnp [F] COG0005 Purine nucleoside phosphorylase 26 1 60 aompkzyqvdrlbcefghsnujxitw NrdA [F] COG0209 Ribonucleotide reductase alpha subunit 20 3 41 -o----yq-drlbcefghsnujxitw NrdF [F] COG0208 Ribonucleotide reductase beta subunit 12 12 18 -o-p----vd-lb-e-gh---j--tw Tdk [F] COG1435 Thymidine kinase 12 14 18 a-m-k---vdrlb-e-g----j---w DeoA [F] COG0213 Thymidine phosphorylase 26 1 48 aompkzyqvdrlbcefghsnujxitw Tmk [F] COG0125 Thymidylate kinase 15 10 28 a-m---y--drlb-efghsn-j---w ThyA [F] COG0207 Thymidylate synthase 21 5 32 -om-kzyqvdrlbcefgh-nuj--tw Upp [F] COG0035 Uracil phosphoribosyltransferase 13 6 26 -o----y-vd-lbce-gh-----itw Udk [F] COG0572 Uridine kinase 8 12 13 -o---z----rl--e-gh------t- Udp [F] COG2820 Uridine phosphorylase 25 2 42 aompkz-qvdrlbcefghsnujxitw PyrH [F] COG0528 Uridylate kinase 11 12 40 ----k-y-vd-lb-efgh-n------ UraA [F] COG2233 Xanthine/uracil permeases 24 3 38 aompkzyqvdrlbcefghsnuj-it- - [F] COG0127 Xanthosine triphosphate pyrophosphatase 15 7 30 ------yq--rlb-ef-hsnujxit- Dut [F] COG0756 dUTPase 9 9 14 -o------v-rlbce-gh-------- MenA [H] COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase 13 7 60 ------y--dr-bcefghsn-jx--- UbiH [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases 15 11 42 a-mpk-yqv-rlb-efg--n----t- UbiB [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibB [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 19 8 30 a-mpkzyq-d--bcefgh-nujxi-- UbiX [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase 19 8 34 a-mpkzyq-d--bcefgh-nujxi-- UbiD [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases 21 6 42 aompkzyq-d--bcefghsnujxi-- UbiA [H] COG0382 4-hydroxybenzoate polyprenyltransferase 22 3 42 -o-p--yqvdrlbcefghsnujxitw FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase 22 4 35 -om--zyq-drlbcefghsnujxitw - [H] COG0212 5-formyltetrahydrofolate cyclo-ligase 18 8 33 aompk--qv---bcefghsnujx--- - [H] COG0720 6-pyruvoyl-tetrahydropterin synthase 17 5 33 ------yqvdrlbcefghsnuj-i-- FolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 19 8 53 --mpk-yq-dr-bcefghsnujxi-- BioF [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes 15 10 45 -o--kz---d-lbcefgh-nuj--t- TbpA [H] COG1840 ABC-type iron/thiamine transport systems, periplasmic component 14 11 38 -o--kz---d--bcefgh-nuj--t- ThiP [H] COG1178 ABC-type thiamine transport system, permease components 11 13 15 -o-pk---vdr--cefg----j---- BtuR [H] COG2109 ATP:corrinoid adenosyltransferase 15 11 51 --m---yq-dr-b-efghsnuj-i-- BioA [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 12 13 19 -o--k--q--r-bcefg-sn-j---- NadB [H] COG0029 Aspartate oxidase 16 10 34 --m---yqv-r-bcefghsnuj-i-- BioB [H] COG0502 Biotin synthase and related enzymes 23 4 38 aom-k-yqvdrlbcefghsnujxit- BirA [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase 13 11 16 aompkz---dr-bc-fg----j---- CbiB [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB 14 11 19 aompkz---dr-bcefg----j---- CobS [H] COG0368 Cobalamin-5-phosphate synthase 11 13 17 aomp-----dr-bc-fg----j---- CobQ [H] COG1492 Cobyric acid synthase 10 13 12 aomp-----dr-bc-f-----j---- CobB [H] COG1797 Cobyrinic acid a,c-diamide synthase 21 6 32 aomp-zyq-dr-bcefghsnujxi-- HemB [H] COG0113 Delta-aminolevulinic acid dehydratase 11 14 17 a-m---y--dr-b-efgh---j---- MenG [H] COG0684 Demethylmenaquinone methyltransferase 26 1 45 aompkzyqvdrlbcefghsnujxitw CoaE [H] COG0237 Dephospho-CoA kinase 15 11 32 --m---yq--r-bcefghsnuj-i-- BioD [H] COG0132 Dethiobiotin synthetase 15 7 40 ------y-vdrlb-efghsn-j-i-w FolA [H] COG0262 Dihydrofolate reductase 15 6 29 ------y--drlbcefghsnuj-i-- FolB [H] COG1539 Dihydroneopterin aldolase 23 4 44 aompkzyqvdrlbcefghsnuj-i-- FolP [H] COG0294 Dihydropteroate synthase 9 8 18 ------y-----b-efghsnu----- - [H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 20 6 55 aompkzyq-dr-bcefghsnuj---- ThiF [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 19 3 34 ------yqvdrlbcefghsnuj-itw RibF [H] COG0196 FAD synthase 20 5 38 -o-p--yqvdrlbcefghsnujx-t- FolC [H] COG0285 Folylpolyglutamate synthase 15 6 26 ------yq-drlbcefghs-ujx--- FolE [H] COG0302 GTP cyclohydrolase I 19 6 41 a--p--yqvdrlbcefghsnuj-i-- RibA [H] COG0807 GTP cyclohydrolase II 25 2 78 aompkzyqvdrlbcefghsnujxit- IspA [H] COG0142 Geranylgeranyl pyrophosphate synthase 19 8 35 aomp-z-q-dr-bcefghsnuj-i-- AlsD [H] COG0001 Glutamate-1-semialdehyde aminotransferase 18 8 27 aomp-z-q-dr-bcefghsnu--i-- HemA [H] COG0373 Glutamyl-tRNA reductase 16 9 34 aom-kz---d--bcefghsn-j---w RimK [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) 8 11 14 a---k-y----lb-e--h--u----- ThiM [H] COG2145 Hydroxyethylthiazole kinase, sugar kinase family 22 5 39 aompkzyqvdrlb-efghsnuj--t- ThiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 17 8 30 -o--kzyqvdr-bcefg-snuj---- PanB [H] COG0413 Ketopantoate hydroxymethyltransferase 13 13 27 ao--kzyq--rlb-efg----j---- ApbA [H] COG1893 Ketopantoate reductase 17 8 27 -o---zyq-dr-bcefghsn-jxi-- LipA [H] COG0320 Lipoate synthase 15 11 42 -o-pkzyqv--lbcefg------i-w LplA [H] COG0095 Lipoate-protein ligase A 12 6 19 ------y--dr--cefghsn-jx--- LipB [H] COG0321 Lipoate-protein ligase B 18 7 28 ---p--yqvdr-bcefghsnujxi-- UbiE [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaA [H] COG2896 Molybdenum cofactor biosynthesis enzyme 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaC [H] COG0315 Molybdenum cofactor biosynthesis enzyme 17 9 42 aompkz-q-dr-bcefgh--uj---- MoeA [H] COG0303 Molybdopterin biosynthesis enzyme 16 10 30 aompkz-q-dr-b-efgh--uj---- MoaB [H] COG0521 Molybdopterin biosynthesis enzymes 17 9 28 aompkz-q-dr-bcefgh--uj---- MoaE [H] COG0314 Molybdopterin converting factor, large subunit 15 11 33 ao-pk--q-dr-bcefgh--uj---- MoaD [H] COG1977 Molybdopterin converting factor, small subunit 13 11 19 aompkz-q----b-e-gh--uj---- MobB [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein 18 8 29 aompkz-q-dr-bcefgh-nuj---- MobA [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A 23 4 41 aompkzyqvdrlbcefg-snuj--tw NadE [H] COG0171 NAD synthase 16 10 36 a---kzyqvdrlb-efgh--uj---- SIR2 [H] COG0846 NAD-dependent protein deacetylases, SIR2 family 14 11 21 aompkz---dr-bcefg----j---- CobT [H] COG2038 NaMN:DMB phosphoribosyltransferase 19 7 32 aom-k-yqv-rlbcefghsnuj---- NadC [H] COG0157 Nicotinate-nucleotide pyrophosphorylase 16 6 32 ------yqv-rlbcefg-snuj--tw NadD [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase 23 4 37 ao-pkzyqvdrlbcefghsnuj--tw PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase 15 10 61 ao-p-z--vdrlbcefgh---j---- DgoA [H] COG1441 O-succinylbenzoate synthase and related enzymes 8 12 16 ------y---rlb-e-gh---j---- CoaA [H] COG1072 Panthothenate kinase 14 7 24 ------yqvdr-bcefg-snuj---- PanC [H] COG0414 Panthothenate synthetase 23 4 45 aompkzyqvdrlbcefghsnuj--t- Dfp [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase 12 8 20 ------y---rlb-efghsnuj---- SerC [HE] COG1932 Phosphoserine aminotransferase 15 10 25 ao-p-zyq-dr-bcef--s--jx--- CyoE [H] COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor) 21 6 33 aomp-zyq-dr-bcefghsnujxi-- HemC [H] COG0181 Porphobilinogen deaminase 12 8 21 aompkzy-vdr-b----h-------- PDX2 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis 18 7 29 ---p--yq-drlbcefghsnujxi-- HemH [H] COG0276 Protoheme ferro-lyase (ferrochelatase) 10 12 15 ao--k-yq-dr-b--------j-i-- HemY [H] COG1232 Protoporphyrinogen oxidase 9 10 12 -o----yq--r--c-fg-s--j---- - [H] COG2154 Pterin-4a-carbinolamine dehydratase 8 12 17 ------y--d-l--ef-h---j--t- PdxK [H] COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase 11 7 18 ------y--dr--cefghsn-j---- PdxH [H] COG0259 Pyridoxamine phosphate oxidase 12 8 21 aompkzy-vdr-b----h-------- SNZ1 [H] COG0214 Pyridoxine biosynthesis enzyme 17 5 28 ------yqvdrlbcefghsnuj-i-- RibD [H] COG0117 Pyrimidine deaminase 21 6 37 aom--zyqvdrlbcefghsnuj-i-- RibD [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis 16 10 25 aom-k--qv-r-bcefg-snuj---- NadA [H] COG0379 Quinolinate synthase 18 5 29 -o----yqvdrlbcefghsnuj-i-- RibC [H] COG0307 Riboflavin synthase alpha chain 21 6 34 aom--zyqvdrlbcefghsnuj-i-- RibH [H] COG0054 Riboflavin synthase beta-chain 14 8 21 aompkzyqv-r--c-f--s--j---- SAM1 [H] COG0499 S-adenosylhomocysteine hydrolase 18 4 34 ------yqvdrlbcefghsnuj--tw MetK [H] COG0192 S-adenosylmethionine synthetase 15 11 27 aomp-zyq--r-b-efg-sn-j---- CysG [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) 17 9 24 aompk--q-dr-bcefg-snuj---- ThiS [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis 15 9 26 aompkz--v--lb-efgh------tw ThiI [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase 15 11 42 aomp-z-qvdr-bce-g---u--i-- ThiH [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes 17 9 24 aom-k--qvdr-bcefg-snuj---- ThiC [H] COG0422 Thiamine biosynthesis protein ThiC 18 8 27 aompkz-q--r-bcefghsnuj---- ThiL [H] COG0611 Thiamine monophosphate kinase 18 8 36 a--pk-yq-drlbcefghsnuj---- ThiE [H] COG0352 Thiamine monophosphate synthase 8 8 11 ------y-vd-lb-------uj--t- THI80 [H] COG1564 Thiamine pyrophosphokinase 17 8 27 ---p--yq-dr-bcefghsnujxi-- HemE [H] COG0407 Uroporphyrinogen-III decarboxylase 17 9 39 aomp-zyq-dr-bcefg-sn-j---- CysG [H] COG0007 Uroporphyrinogen-III methylase 19 8 36 aomp--yq-dr-bcefghsnu-xi-- HemD [H] COG1587 Uroporphyrinogen-III synthase 18 4 41 ------yqvdrlbcefghsnujxi-- FabD [I] COG0331 (acyl-carrier-protein) S-malonyltransferase 20 2 81 ------yqvdrlbcefghsnujxitw PlsC [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase 12 12 58 ao-p-z---dr-b-efg----jx--- FadB [I] COG1250 3-Hydroxyacyl-CoA dehydrogenase 11 8 17 aompkzy----lb--------j--t- PksG [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase 17 9 41 --mp-zyq-drlbcefgh-nuj---- MmsB [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related proteins 18 4 59 ------yqvdrlbcefghsnujxi-- FabB [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase 8 10 21 ------y---r--ce--h-nuj---- SbmA [I] COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components 20 6 120 aompkzy--drlbcefgh--ujx-t- PaaJ [I] COG0183 Acetyl-CoA acetyltransferases 21 6 58 ao--k-yqvdrlbcefghsnujxi-- AccA [I] COG0825 Acetyl-CoA carboxylase alpha subunit 20 7 56 ao--k--qvdrlbcefghsnujxi-- AccD [I] COG0777 Acetyl-CoA carboxylase beta subunit 6 9 10 a-m----qv--l--e----------- - [I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) 20 2 59 ------yqvdrlbcefghsnujxitw AcpP [IQ] COG0236 Acyl carrier protein 13 11 187 ao-p-zy--dr-b-efg--n-j---- CaiA [I] COG1960 Acyl-CoA dehydrogenases 14 10 34 -o-p-zy--d--b-efgh-nuj-i-- - [I] COG1607 Acyl-CoA hydrolase 21 5 165 aomp-zy--drlbcefghsnujxi-- CaiC [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 14 10 28 ao-p-zy--drlb-ef-h--uj---- AtoD [I] COG1788 Acyl-CoA:acetate CoA transferase alpha subunit 13 11 27 -o-p-zy--drlb-ef-h--uj---- AtoA [I] COG2057 Acyl-CoA:acetate CoA transferase beta subunit 18 8 64 aomp-zyq-dr-bcefghs-uj---- Acs [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases 22 5 60 ao--k-yqvdrlbcefghsnujxit- AccB [I] COG0511 Biotin carboxyl carrier protein 21 6 70 aom---yq-drlbcefghsnujxit- AccC [I] COG0439 Biotin carboxylase 26 1 48 aompkzyqvdrlbcefghsnujxitw CdsA [I] COG0575 CDP-diglyceride synthetase 9 11 19 a-mpk-yq-----c--------x-t- SEC59 [I] COG0170 Dolichol kinase 16 9 151 ao-p-zyq-drlb-efg-s--jx--- CaiD [I] COG1024 Enoyl-CoA hydratase/carnithine racemase 15 10 60 a--p--y-vdrlbcefg-s--j--t- Aes [I] COG0657 Esterase/lipase 6 12 19 ------y---r-bc-f-----j---- DesA [I] COG3239 Fatty acid desaturase 10 8 16 aompkzy----l----g-------t- HMG1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase 11 12 28 ao---zyq--r--c-fgh------t- FAA1 [I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming) 13 13 32 a---k-y-vdrlb-efgh---j---- PldB [I] COG2267 Lysophospholipase 19 7 74 -om-k-yq-drlbcefghs-ujx-t- PgpB [I] COG0671 Membrane-associated phospholipid phosphatase 10 12 24 ao-pkz---dr-b-e------j---- Sbm [I] COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) 10 12 25 ao-pkz---dr-b-e------j---- Sbm [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit 8 8 14 aom-kzy----l------------t- ERG12 [I] COG1577 Mevalonate kinase 5 9 12 -o-p--y----l------------t- MVD1 [I] COG3407 Mevalonate pyrophosphate decarboxylase 8 5 12 a-m-kzyqv-r--------------- INO1 [I] COG1260 Myo-inositol-1-phosphate synthase 13 10 23 --m-kz-q---lb-efgh-nu-x--- PgpA [I] COG1267 Phosphatidylglycerophosphatase A 25 2 71 aompkzyqv-rlbcefghsnujxitw PgsA [I] COG0558 Phosphatidylglycerophosphate synthase 17 9 31 aom---y--dr-b-efghsnujxi-- Psd [I] COG0688 Phosphatidylserine decarboxylase 14 10 24 aom---y---r-b--f--snujxit- PssA [I] COG1183 Phosphatidylserine synthase 18 7 62 a--p--y-v--lbcefghsnujxi-w Cls [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes 16 6 33 ------yqvdrlb-e-g--nujxitw AcpS [I] COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) 9 11 17 -om---y--dr-bc-----n-j---- ERG9 [I] COG1562 Phytoene/squalene synthetase 11 12 48 ao----y--dr-b-efgh---j---- MaoC [I] COG2030 Predicted acyl dehydratase 8 13 16 a--p-zyq----b--f-----j---- - [I] COG3255 Putative sterol carrier protein 6 11 23 ------y---r--c-fg----j---- ERG3 [I] COG3000 Sterol desaturase 25 2 49 aompkzyqvdrlbcefghsnujxit- UppS [I] COG0020 Undecaprenyl pyrophosphate synthase 18 7 53 aompkzy--dr-bcefgh-nuj---- MhpD [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) 24 3 228 aompkzy-vdrlbcefghsnujx-tw CcmA [Q] COG1131 ABC-type multidrug transport system, ATPase component 21 5 204 -o--k-yqvdrlbcefghsnujxi-w MdlB [Q] COG1132 ABC-type multidrug/protein/lipid transport system, ATPase component 19 8 70 ao-pkzyqv-rlb-efg-snuj--t- PncA [Q] COG1335 Amidases related to nicotinamidase 10 9 73 -o----y--dr-bc-f--s-uj---- CypX [Q] COG2124 Cytochrome P450 23 4 481 ao-pkzyqvdrlbcefghsnujxi-- FabG [QR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 9 15 28 ---p--yq--r-bcef-----j---- - [Q] COG0412 Dienelactone hydrolase and related enzymes 14 11 29 aompk-y-vdrlb--fg----j---- HutI [Q] COG1228 Imidazolonepropionase and related amidohydrolases 23 4 83 aom-kzyqvdrlbcefghsnuj--tw NorM [Q] COG0534 Na+-driven multidrug efflux pump 10 10 70 ------y---rlb-efg-s-uj---- EntF [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins 8 11 26 -om--z---dr-bc-------j---- - [Q] COG1233 Phytoene dehydrogenase and related proteins 12 10 35 -o----yq--r-b-ef-hsnuj---- SufI [Q] COG2132 Putative multicopper oxidases 26 1 493 aompkzyqvdrlbcefghsnujxitw SmtA [QR] COG0500 SAM-dependent methyltransferases 5 10 6 ------y-vd----e------j---- IndA [Q] COG2313 Uncharacterized enzyme involved in pigment biosynthesis 15 11 54 ao-pk--q-drlb-efgh--uj---- PaaI [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism 20 6 129 aompkzy-vdrlbcefghs-uj---- - [R] COG0842 ABC-type multidrug transport system, permease component 12 9 33 ao-pkz--vd--bc-f--------tw NosY [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component 23 4 121 aom--z-qvdrlbcefghsnujxitw PhnL [R] COG1136 ABC-type transport systems, involved in lipoprotein release, ATPase components 21 6 104 aom----qvdrlbcefghsnujxit- - [R] COG0577 ABC-type transport systems, involved in lipoprotein release, permease components 17 4 93 ------y--drlbcefghsnujxit- Uup [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains 10 13 39 -omp------r--cefg---uj---- - [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase 23 3 65 aompkzyqvdrlbcefghsnuj---w RimI [R] COG0456 Acetyltransferases 18 8 60 -om-k-y-vdrlbcefgh-nuj-i-- WbbJ [R] COG0110 Acetyltransferases (the isoleucine patch superfamily) 14 12 56 -o-pkzy-v-rlbcefg----j---- ARA1 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase 14 8 66 ---p--y--d---cefghsnujx-t- Arp [R] COG0666 Ankyrin repeat proteins 11 9 18 ao-------dr--cefgh-nu----- Pta [R] COG0857 BioD-like N-terminal domain of phosphotransacetylase 25 2 212 aompkzyqvdrlbcefghsnujxit- - [R] COG0517 CBS domains 17 9 35 --mpk-yq-dr-bcefg-snujx--- PaaY [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 19 7 45 a-mpkzyqvdrlbcef-h-n-jx--- - [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family 13 9 30 a-----yqvdrlb--f--snuj---- - [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase 8 11 15 a-m-k-y--dr-b-e----------- - [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster 26 1 81 aompkzyqvdrlbcefghsnujxitw ARC1 [R] COG0073 EMAP domain 15 6 37 aom-kz-qvdrlbc--g-------tw - [R] COG0618 Exopolyphosphatase-related proteins 7 4 10 aom-kzy-v----------------- - [R] COG1635 Flavoproteins, possibly involved in thiazole biosynthesis 11 8 97 aompkzyq-d---c-------j---- - [R] COG1100 GTPases 19 7 28 -om-kz-qvdrlbcefghsn-j-i-- HflX [R] COG2262 GTPases 11 5 23 aompkz-qv--lb------------w - [R] COG1078 HD superfamily phosphohydrolases 11 11 16 aomp-z-q-dr-b--------j-i-- - [R] COG1331 Highly conserved protein containing a thioredoxin domain 16 11 50 ao--kzy-vdrlb-efg-s--j-i-- - [R] COG1073 Hydrolases of the alpha/beta superfamily 15 6 28 ------y--d-lbcefgh-nujxit- - [R] COG0670 Integral membrane protein, interacts with FtsH 17 10 28 aompkz--vdrlbce---s--j-it- - [R] COG0396 Iron-regulated ABC transporter ATPase subunit SufC 16 9 55 aompk---vd-lb-efghsn-j---- RfbX [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 14 12 42 -o-pk---vdrlbcef-h--uj---- AbgB [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase 15 12 32 aompk--q---lbcef-----jxit- PhnP [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I 18 9 39 aompkzy-vdrlbce--h---j-it- ElaC [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 19 8 79 aompkzyqvdr-bcefg-s--j--t- - [R] COG0714 MoxR-like ATPases 12 14 31 a-m---yq-dr-b-efg-s--j---- WrbA [R] COG0655 Multimeric flavodoxin WrbA 12 12 34 aom-k--q----b---gh-nu--it- - [R] COG0733 Na+-dependent transporters of the SNF family 15 10 38 -om-k---vd-lb-efgh-nuj--t- - [R] COG2252 Permeases 5 11 9 ------yq--r-b--------j---- - [R] COG2270 Permeases of the major facilitator superfamily 18 9 31 aompk-yq--r-b-e-ghsnuj-i-w - [R] COG1881 Phospholipid-binding protein 9 12 24 ---p--y---r--cefgh---j---- - [R] COG1741 Pirin-related protein 10 8 18 ------y--dr---efg-sn-jx--- - [R] COG1485 Predicted ATPase 17 9 39 aompkz-qvdrlbcef-h---j---- - [R] COG0433 Predicted ATPase 18 8 31 aompkz-q----bcefghsnujx--- - [R] COG0603 Predicted ATPase (PP-loop superfamily), confers aluminum resistance 7 4 10 a-mpkz-qv----------------- - [R] COG1618 Predicted ATPases or kinases 13 9 18 -o-pkzyqvd-lb-e-----uj---- - [R] COG1832 Predicted CoA-binding protein 15 9 53 aompkz-qvdrlbc-f-----j---- - [R] COG0535 Predicted Fe-S oxidoreductases 11 13 27 aom-k----d-l-cef--s-u----- - [R] COG0727 Predicted Fe-S-cluster oxidoreductase 19 3 33 ------yqvd-lbcefghsnujxitw ThdF [R] COG0486 Predicted GTPase 20 2 35 ------yqvdrlbcefghsnujxitw Obg [R] COG0536 Predicted GTPase 26 1 49 aompkzyqvdrlbcefghsnujxitw - [R] COG0012 Predicted GTPase 12 12 34 --m-kzy-v--lbc--g--n----tw - [R] COG1161 Predicted GTPases 19 5 33 aom-k-yqv--lb-efghsnujx--w - [R] COG0218 Predicted GTPases 8 11 29 ------y--dr-bcef----u----- - [R] COG0699 Predicted GTPases (dynamin-related) 14 7 31 aompk--qvd-lb-e-----u---tw - [R] COG1418 Predicted HD superfamily hydrolase 9 12 19 ------yq--r-bcef---n-j---- - [R] COG0385 Predicted Na+-dependent transporter 19 8 35 a--pk-yqvdrlb-efghsnuj-i-- - [R] COG1611 Predicted Rossmann fold nucleotide-binding protein 20 2 34 ------yqvdrlbcefghsnujxitw - [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase 16 9 33 --m-kz-qvd-lb-efghsn-j-i-- - [R] COG1092 Predicted SAM-dependent methyltransferases 22 5 64 aom---yqvdrlbcefghsnujxit- - [R] COG0042 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family 20 6 41 aompkzy-vdrlbcefghs-uj---- - [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold 18 7 62 -----zyqvdrlbcefghs-ujx-t- PqqL [R] COG0612 Predicted Zn-dependent peptidases 4 6 10 ------y--d-------------it- - [R] COG1026 Predicted Zn-dependent peptidases, insulinase-like 6 5 9 aom-kz-q------------------ - [R] COG1913 Predicted Zn-dependent proteases 18 8 65 a-mpkz-qvdr-bcefghsn-j---- TldD [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs 9 12 24 a-----y--d--bc-fg-s------w LipA [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold 7 4 10 a-mpkz-qv----------------- - [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 21 6 79 aompkzyqvdr-bcefg-snuj--t- - [R] COG0388 Predicted amidohydrolase 7 12 14 -o----y--dr-b--f-----j---- - [R] COG3173 Predicted aminoglycoside phosphotransferase 13 6 21 ------yq-dr--cefghsn-jx--- - [R] COG0354 Predicted aminomethyltransferase related to GcvT 12 13 30 -om-k-yq--r-b-efg-s--j---- Iap [R] COG2234 Predicted aminopeptidases 17 9 29 a--pkzy-v-r-bcefg-snuj---w - [R] COG0579 Predicted dehydrogenase 16 10 103 --mpk-yqvd-lbcefgh--uj---- MviM [R] COG0673 Predicted dehydrogenases and related proteins 9 4 14 a-mpkzyqv------------j---- - [R] COG1355 Predicted dioxygenase 3 5 8 ------y-v---b------------- - [R] COG3341 Predicted double-stranded RNA/RNA-DNA hybrid binding protein 16 5 27 ------yqvdrlbcefghsnuj---- - [R] COG0325 Predicted enzyme with a TIM-barrel fold 11 10 26 -o----y--dr-bcefgh---j---- - [R] COG0384 Predicted epimerase, PhzC/PhzF homolog 11 10 17 ------y--d-lbcef--s--jxi-- - [R] COG0400 Predicted esterase 9 11 25 ------y---rl-cef-h-n-j---- - [R] COG0627 Predicted esterase 16 6 41 ------yqv-rlbcefghsn-jx-t- RssA [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily 9 13 13 aom-k---v---b--f----u---t- - [R] COG1033 Predicted exporters of the RND superfamily 8 13 15 -omp------rlb------n-j---- - [R] COG3467 Predicted flavin-nucleotide-binding protein 14 7 34 -o----y--drlbcefgh-n-j---w - [R] COG0431 Predicted flavoprotein 12 11 22 --mpk-y---r--cefgh-n-j---- - [R] COG0121 Predicted glutamine amidotransferase 8 3 18 aompkzyq------------------ - [R] COG1204 Predicted helicases 9 9 16 a-m-kz-qv--lb-e----------- - [R] COG1203 Predicted helicases 6 7 8 ------y-vd-lbc------------ - [R] COG2179 Predicted hydrolase of the HAD superfamily 8 10 10 a-mpk--qv-r-b------------- - [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs) 13 7 33 -om-k---vdrlbc------ujx--w - [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily 11 10 18 ao--kzy--d----efgh--u----- - [R] COG1896 Predicted hydrolases of HD superfamily 19 8 85 -ompk-yqvdrlb-efghsn-j--t- - [R] COG1011 Predicted hydrolases of the HAD superfamily 21 6 90 aompkzy-vdrlbce-gh-n-j-itw Cof [R] COG0561 Predicted hydrolases of the HAD superfamily 22 4 276 ao-p-zyq-drlbcefghsnujx-tw MhpC [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 14 12 33 aom-k--qv-r-bcef--s--j---w - [R] COG0392 Predicted integral membrane protein 24 3 48 aompkzyqv-rlbcefghsnujx-tw - [R] COG0061 Predicted kinase 13 11 18 a-m---yqvdrlbc-f---n-j---- ArgJ [R] COG1364 Predicted kinase related to thiamine pyrophosphokinase 17 10 51 aompkz--vdrlbce---s--j-it- - [R] COG0719 Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufB 12 9 23 ------y--drlb-efg-sn-j--t- - [R] COG1272 Predicted membrane proteins, hemolysin III homologs 14 10 28 aom-k--q-d----efg-snuj---w - [R] COG1451 Predicted metal-dependent hydrolase 11 13 17 -o-pkz-qvdr-b--f-----j---- - [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold 10 14 19 ---pkzy-vd--b--fg----j---- - [R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain 17 9 48 -om-kz-qvdrlbcefg----j-it- - [R] COG1266 Predicted metal-dependent membrane protease 14 11 23 aom--z-qvd--bcefgh-n------ - [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family) 6 10 11 ao--k--q--r--c------------ - [R] COG2402 Predicted nucleic acid-binding protein, contains PIN domain 16 10 24 ao-pkzy-vdrlbce-g--n-j---- CinA [R] COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA 7 6 34 a-m-kz-qv--------h-------- - [R] COG1708 Predicted nucleotidyltransferases 7 13 16 a-m-----vd---c-----n-j---- - [R] COG1669 Predicted nucleotidyltransferases 10 14 18 ao---z---d--bc-fgh----x--- - [R] COG2358 Predicted periplasmic binding protein 8 10 12 a--p-z-q-d--b-------u--i-- - [R] COG1427 Predicted periplasmic solute-binding protein 8 10 12 a--p-z-q-d--b-------u--i-- - [R] COG2107 Predicted periplasmic solute-binding protein 21 6 71 aom-k--qvdrlbcefghsnujx-t- PerM [R] COG0628 Predicted permease 10 11 14 a-m----qv-rlbce-----u----- - [R] COG0701 Predicted permeases 21 5 93 aompkz-qvdrlbcefghsnuj---- - [R] COG0730 Predicted permeases 14 11 30 --m---yqv---bcefghs-ujx--- - [R] COG0679 Predicted permeases 16 10 55 ----k-y-vdrlbcefghsn-j-i-- - [R] COG0637 Predicted phosphatase/phosphohexomutase 21 6 53 aom-k-yq-drlbcefghsnuj--tw Gph [R] COG0546 Predicted phosphatases 15 11 30 aom-kzy-v-rlb-efg-------tw - [R] COG0622 Predicted phosphoesterase 6 5 8 aom-kz-q------------------ - [R] COG2129 Predicted phosphoesterases, related to the Icc protein 14 11 31 a-m-kzyq--r--cefgh---j-i-- Icc [R] COG1409 Predicted phosphohydrolases 9 7 21 ao-pkzy------------nu---t- - [R] COG2236 Predicted phosphoribosyltransferases 18 9 37 a---kz-qvdrlbcefghs--j-it- MazG [R] COG1694 Predicted pyrophosphatase 18 9 43 -omp-z-q-dr-bcefghsnuj--t- FcbC [R] COG0824 Predicted thioesterase 10 11 29 -o-p----vd----efg-s-uj---- - [R] COG2391 Predicted transporter components 15 10 36 -omp--y---r-bcefghsn-jx--- AarF [R] COG0661 Predicted unusual protein kinase 4 9 14 ------y-----------s--j-i-- - [R] COG2940 Proteins containing SET domain 13 8 29 ------yq-dr-bcefg-snuj---- - [R] COG0523 Putative GTPases (G3E family) 6 13 12 -o----y-----b-ef-----j---- - [R] COG2130 Putative NADP-dependent oxidoreductases 12 14 22 --mpkz--vdrlb-e---s--j---- PaaD [R] COG2151 Putative aromatic ring hydroxylating enzyme 21 6 77 aompkzyq-dr-bcefghs-uj--tw ThiJ [R] COG0693 Putative intracellular protease/amidase 12 9 32 -o----y---rlb-ef-hsnuj---- DltE [R] COG0300 Short-chain dehydrogenases of various substrate specificities 19 6 30 aom--zyqvd---cefghsnuj-it- SurE [R] COG0496 Survival protein, predicted acid phosphatase 9 8 58 ------y--d----efgh-nuj---- - [R] COG0790 TPR repeat proteins 23 4 321 aompk-yqvd-lbcefghsnujxit- NrfG [R] COG0457 TPR-repeat-containing proteins 7 12 10 ------y--d--b-ef----uj---- - [R] COG2351 Transthyretin-like protein 12 12 48 ao--kz--vd-lb--f-----j--tw - [R] COG1079 Uncharacterized ABC-type transport system, permease component 13 9 19 aom-k---vd-lbc-------jxit- BioY [R] COG1268 Uncharacterized ACR 12 14 18 aompk---v-r-bc-f-h---j---- - [R] COG1878 Uncharacterized ACR, predicted metal-dependent hydrolases 6 13 17 a-m----q-dr--------n------ - [R] COG2018 Uncharacterized ACR; distantly related to eukaryotic homeotic protein bithoraxoid 8 13 23 --mpk---v-r------h--uj---- - [R] COG1373 Uncharacterized ATPases of the AAA superfamily 21 2 82 -o----yqvdrlbcefghsnujxitw - [R] COG1253 Uncharacterized CBS domain-containing proteins 8 17 9 a---k---v--lbc--g----j---- - [R] COG2509 Uncharacterized FAD-dependent dehydrogenases 6 5 9 a-m-kz-qv----------------- PflX [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins 21 6 99 aompkzyqvdrlbcefgh---j--tw HcaD [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases 9 13 19 -o-p-zy--dr-b--f-----j---- - [R] COG2329 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides 13 12 21 ao-p-z-q-dr-b-ef-h--uj---- - [R] COG2041 Uncharacterized enzymes, related to nitrate reductase 22 5 44 aompkzyqvdrlbcefghs-uj--t- GlpG [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) 17 5 30 -o----yqvdrlbcefg-snuj---w CinA [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) 13 9 25 -o---zyq-d--b--fg-snujx--- - [R] COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems 9 16 17 --mp-zy---r-b-ef-----j---- PrpD [R] COG2079 Uncharacterized protein involved in propionate catabolism 8 12 14 -om--z--v-r-bc-------j---- - [R] COG1402 Uncharacterized protein, putative amidase 10 12 26 a--pk-y-v---b--f--s-uj---- - [R] COG1524 Uncharacterized proteins of the AP superfamily 6 12 161 ------y-vd---c--g----j---- - [R] COG2319 WD40 repeat protein 8 11 16 a-m-k--q-d---ce-----u----- HybF [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) 13 11 45 ---p-zy---rlbcef--snuj---- AdhP [R] COG1064 Zn-dependent alcohol dehydrogenases 22 4 157 aompkzyqvdrlbcefghsnuj---- GloB [R] COG0491 Zn-dependent hydrolases, including glyoxylases 16 9 27 aompkz-qvdr-bc--g--nuj---- SpoIVFB [R] COG1994 Zn-dependent proteases 13 13 40 ao---z--vd--bcefgh---j--t- - [S] COG1593 Integral membrane protein, possible transporter 18 8 41 a-mpkz-q-d--b-efghsnuj-it- MarC [S] COG2095 Integral membrane proteins of the MarC family 3 6 5 -o-p----v----------------- - [S] COG3462 Predicted membrane protein 4 9 6 -o-----q-d--b------------- - [S] COG2322 Predicted membrane protein 7 11 8 -om-----v--lb---g-------t- - [S] COG2035 Predicted membrane protein 7 11 11 -o----y---r--c-fg----j---- - [S] COG2119 Predicted membrane protein 5 8 8 -o-pk--q-----c------------ - [S] COG3431 Predicted membrane protein 5 8 9 ------yq--r--ce----------- - [S] COG2149 Predicted membrane protein 4 7 9 -o-p---q-----------n------ - [S] COG3439 Uncharacterized ACR 18 6 29 aompkzyqvdr--cefg-s-uj---- - [S] COG0062 Uncharacterized ACR 13 12 23 aompkz-qvdr-b-ef---------- RtcB [S] COG1690 Uncharacterized ACR 13 12 24 a--pkz-qvd--b-efgh---j---- - [S] COG1801 Uncharacterized ACR 9 12 14 ao-------d-lb-e--h-nu----- - [S] COG1556 Uncharacterized ACR 11 14 19 ---pk--qvd--b-efg--n-j---- - [S] COG1765 Uncharacterized ACR 7 11 9 aomp---q-d-----------j---- - [S] COG1416 Uncharacterized ACR 5 6 12 ao-p---q----b------------- - [S] COG2210 Uncharacterized ACR 9 4 12 aompkz-qv-r--------------- - [S] COG1371 Uncharacterized ACR 18 7 28 aompk--qvdrlbc-f--sn-j--tw - [S] COG1354 Uncharacterized ACR 4 7 5 -omp----v----------------- - [S] COG3367 Uncharacterized ACR 5 8 6 a-m----qv---b------------- - [S] COG1336 Uncharacterized ACR 7 11 9 a-mp----v-rlb------------- - [S] COG1343 Uncharacterized ACR 13 7 23 ------y-vd-lb-efgh-nu---tw - [S] COG1739 Uncharacterized ACR 18 7 38 aom-k-y--drlb-efgh-nu--itw - [S] COG0327 Uncharacterized ACR 14 7 51 ------yq-dr-bcefghsn-jx--- IscA [S] COG0316 Uncharacterized ACR 8 8 10 ao---z-qv-r--c---------i-- - [S] COG1259 Uncharacterized ACR 14 11 21 ao---z--vd--b-efgh-n-j-it- - [S] COG1738 Uncharacterized ACR 6 5 8 aompk---v----------------- - [S] COG1833 Uncharacterized ACR 9 7 11 aom-kz-qv-----e-----u----- - [S] COG1912 Uncharacterized ACR 12 9 20 aom-kz--v-----efgh-n-j---- - [S] COG1720 Uncharacterized ACR 6 12 8 --mp----vd--bc------------ - [S] COG2045 Uncharacterized ACR 14 11 23 a-m-kzyqvdr-bcefg--------- - [S] COG0432 Uncharacterized ACR 9 2 13 aompkzyqv----------------- - [S] COG2078 Uncharacterized ACR 14 8 23 aompkzyq-d----efgh--u----- - [S] COG0585 Uncharacterized ACR 5 6 7 a-m-k--qv----------------- - [S] COG1578 Uncharacterized ACR 12 12 20 aompkz--vd-l-c-f-----j---- - [S] COG2013 Uncharacterized ACR 14 12 22 aompk---v-rlbce-gh---j---- - [S] COG0393 Uncharacterized ACR 11 7 16 aompk-yqv-r-bc------------ - [S] COG0011 Uncharacterized ACR 6 5 13 a-mpk--qv----------------- - [S] COG1583 Uncharacterized ACR 7 13 17 ------y---r-bce-g----j---- - [S] COG0398 Uncharacterized ACR 8 12 11 ------y-----bcefg-s--j---- - [S] COG0397 Uncharacterized ACR 11 13 31 ---p--y-vdrlbcef-----j---- BmrU [S] COG1597 Uncharacterized ACR 14 8 22 aom---yqvdrlbce-gh-------- - [S] COG0391 Uncharacterized ACR 9 15 18 a-mp----v----ce----nuj---- - [S] COG1598 Uncharacterized ACR 14 11 21 a-mpkz-qv-rlb-e--h-nu----- - [S] COG1518 Uncharacterized ACR 10 10 12 ------y-v-r-b--fg-snuj---- - [S] COG1610 Uncharacterized ACR 8 9 11 a--pkz-qv-r-------------t- - [S] COG1656 Uncharacterized ACR 7 14 18 -o----y---r-b-ef-----j---- - [S] COG2135 Uncharacterized ACR 8 8 12 ------yq-----c----snujx--- - [S] COG1565 Uncharacterized ACR 8 5 11 aompkz-q---l-------------- - [S] COG1812 Uncharacterized ACR 13 11 31 aom-k--q-d---c-fg--nuj--t- - [S] COG1432 Uncharacterized ACR 8 13 12 -om-k---v----c----s--j--t- - [S] COG1430 Uncharacterized ACR 6 12 9 aom-------rl-----------i-- - [S] COG1478 Uncharacterized ACR 10 11 37 -om-k---v-----e-gh-nu----w - [S] COG1479 Uncharacterized ACR 15 11 35 ao-pkz-qvdr-bc-fg----j--t- - [S] COG1721 Uncharacterized ACR 5 5 10 -om-kz--v----------------- - [S] COG1992 Uncharacterized ACR 10 13 15 ao-pkz---dr-b--f-----j---- - [S] COG2096 Uncharacterized ACR 4 7 5 aom----q------------------ - [S] COG1465 Uncharacterized ACR 20 2 37 ------yqvdrlbcefghsnujxitw - [S] COG0217 Uncharacterized ACR 3 5 5 ------y-v---------s------- - [S] COG2930 Uncharacterized ACR 12 7 19 aom-k--q-d-lbc---------itw - [S] COG1624 Uncharacterized ACR 11 10 16 aompkz--v---b--f--sn------ - [S] COG1469 Uncharacterized ACR 13 13 23 a--pkzyqvdrl--ef-----j---- - [S] COG2110 Uncharacterized ACR related to the C-terminal domain of histone macroH2A1 12 11 24 aompkz-q-dr--cef---------- - [S] COG1310 Uncharacterized ACR, PAD1/JAB1-related 7 6 10 ------yqvd-lb-----------t- - [S] COG1774 Uncharacterized ACR, PSP1 homologs 5 11 6 ------yq----b--f--s------- - [S] COG1791 Uncharacterized ACR, double-stranded beta-helix domain 12 9 23 -ompk--qv-rlbc------uj---- - [S] COG1917 Uncharacterized ACR, double-stranded beta-helix domain 15 11 35 a-mp--y-vdrlbc-f-hsn-j---- - [S] COG0599 Uncharacterized ACR, homolog of gamma-carboxymuconolactone decarboxylase subunit 7 11 9 -o----------b--f--sn-j-i-- - [S] COG2928 Uncharacterized BCR 7 10 9 -o-p-z-q-d--bc------------ - [S] COG1547 Uncharacterized BCR 8 9 15 -o-----q------ef-h-nuj---- - [S] COG3177 Uncharacterized BCR 3 7 4 -om-----v----------------- - [S] COG3472 Uncharacterized BCR 12 10 43 -o-------drlbcef-h---jx-t- - [S] COG1357 Uncharacterized low-complexity proteins 10 12 14 -o--k-y---r----f-hsnuj---- - [S] COG1297 Uncharacterized membrane protein 6 12 8 -om--z-q-------f-----j---- - [S] COG3174 Uncharacterized membrane protein 11 12 21 a-mpkzy-vd-l---f-----j---- - [S] COG1814 Uncharacterized membrane proteins 7 14 20 a-----y--d--b--f-----j--t- - [S] COG2340 Uncharacterized protein with SCP/PR1 domains 15 12 34 aom-k---vdr-b-efg-s--jx-t- - [S] COG1520 Uncharacterized proteins of WD40-like repeat family 6 13 20 ----k-y--dr-b--------j---- - [S] COG2120 Uncharacterized proteins, LmbE homologs LUCA1.0 - rRNA tree topology Total number of events, gains and losses are 14085 8206 5879 Total inconsistency = 14085 643 COGs 4 23 4 3 59 aompkz-qvdr-bcefghsnujxit- MiaB [J] COG0621 2-methylthioadenine synthetase 5 18 8 - 99 -o-pk-y-vdrlb-efgh-nujx--w RimL [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins 6 26 1 4 44 aompkzyqvdrlbcefghsnujxitw AlaS [J] COG0013 Alanyl-tRNA synthetase 9 26 1 5 46 aompkzyqvdrlbcefghsnujxitw ArgS [J] COG0018 Arginyl-tRNA synthetase 10 20 5 * 73 aom--zyqvdrlbc-f---nujxitw GatA [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases 11 20 5 3 34 aom--zyqvdrlbc-f---nujxitw GatB [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) 12 19 6 - 30 aom--z-qvdrlbc-f---nujxitw GatC [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit 13 20 2 2 35 ------yqvdrlbcefghsnujxitw AspS [J] COG0173 Aspartyl-tRNA synthetase 15 25 2 4 44 ao-pkzyqvdrlbcefghsnujxitw CysS [J] COG0215 Cysteinyl-tRNA synthetase 18 26 1 4 50 aompkzyqvdrlbcefghsnujxitw KsgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) 23 26 1 * 85 aompkzyqvdrlbcefghsnujxitw TufB [JE] COG0050 GTPases - translation elongation factors 24 26 1 6 75 aompkzyqvdrlbcefghsnujxitw GlnS [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases 28 26 1 2 58 aompkzyqvdrlbcefghsnujxitw HisS [J] COG0124 Histidyl-tRNA synthetase 30 26 1 6 46 aompkzyqvdrlbcefghsnujxitw IleS [J] COG0060 Isoleucyl-tRNA synthetase 31 26 1 4 48 aompkzyqvdrlbcefghsnujxitw LeuS [J] COG0495 Leucyl-tRNA synthetase 33 17 4 2 37 ------yqvdrlbcefghsnu--i-w LysU [J] COG1190 Lysyl-tRNA synthetase class II 34 26 1 8 55 aompkzyqvdrlbcefghsnujxitw Map [J] COG0024 Methionine aminopeptidase 35 20 2 3 40 ------yqvdrlbcefghsnujxitw Fmt [J] COG0223 Methionyl-tRNA formyltransferase 36 26 1 3 48 aompkzyqvdrlbcefghsnujxitw MetG [J] COG0143 Methionyl-tRNA synthetase 43 20 2 - 37 ------yqvdrlbcefghsnujxitw Pth [J] COG0193 Peptidyl-tRNA hydrolase 44 26 1 5 46 aompkzyqvdrlbcefghsnujxitw PheS [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit 46 26 1 5 46 aompkzyqvdrlbcefghsnujxitw PheT [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit 52 10 3 2 15 aompkzyqv-r--------------- GCD14 [J] COG2519 Predicted SAM-dependent methyltransferase involved in tRNA-Met maturation 59 25 2 3 58 aompk-yqvdrlbcefghsnujxitw HemK [J] COG2890 Predicted rRNA or tRNA methylase 62 20 2 2 39 ------yqvdrlbcefghsnujxitw TrmU [J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain 63 26 1 4 47 aompkzyqvdrlbcefghsnujxitw ProS [J] COG0442 Prolyl-tRNA synthetase 64 20 2 3 36 ------yqvdrlbcefghsnujxitw PrfA [J] COG0216 Protein chain release factor A 65 19 3 - 41 ------yqvdrlbcefghsnujxit- PrfB [J] COG1186 Protein chain release factor B 69 26 1 3 45 aompkzyqvdrlbcefghsnujxitw TruB [J] COG0130 Pseudouridine synthase 70 25 2 5 46 aompk-yqvdrlbcefghsnujxitw TruA [J] COG0101 Pseudouridylate synthase (tRNA psi55) 71 20 2 4 101 ------yqvdrlbcefghsnujxitw RluA [J] COG0564 Pseudouridylate synthases, 23S RNA-specific 72 25 2 1 54 aompkzyqvdrlbcefghsn-jxitw SUA5 [J] COG0009 Putative translation factor (SUA5) 73 19 6 2 76 -o--kzyqvdrlbcefghsnuj---- TdcF [J] COG0251 Putative translation initiation inhibitor 75 23 4 4 38 aompkz-qvd-lbcefghsnujxit- Tgt [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase 87 26 1 7 47 aompkzyqvdrlbcefghsnujxitw RplA [J] COG0081 Ribosomal protein L1 88 26 1 6 49 aompkzyqvdrlbcefghsnujxitw RplJ [J] COG0244 Ribosomal protein L10 89 26 1 4 49 aompkzyqvdrlbcefghsnujxitw RplK [J] COG0080 Ribosomal protein L11 92 26 1 5 48 aompkzyqvdrlbcefghsnujxitw RplM [J] COG0102 Ribosomal protein L13 93 26 1 4 47 aompkzyqvdrlbcefghsnujxitw RplN [J] COG0093 Ribosomal protein L14 95 26 1 2 45 aompkzyqvdrlbcefghsnujxitw RplO [J] COG0200 Ribosomal protein L15 97 26 1 4 48 aompkzyqvdrlbcefghsnujxitw RplP [J] COG0197 Ribosomal protein L16/L10E 98 20 2 2 35 ------yqvdrlbcefghsnujxitw RplQ [J] COG0203 Ribosomal protein L17 99 26 1 2 44 aompkzyqvdrlbcefghsnujxitw RplR [J] COG0256 Ribosomal protein L18 101 20 2 1 35 ------yqvdrlbcefghsnujxitw RplS [J] COG0335 Ribosomal protein L19 103 26 1 5 45 aompkzyqvdrlbcefghsnujxitw RplB [J] COG0090 Ribosomal protein L2 108 26 1 3 48 aompkzyqvdrlbcefghsnujxitw RplV [J] COG0091 Ribosomal protein L22 109 26 1 4 43 aompkzyqvdrlbcefghsnujxitw RplW [J] COG0089 Ribosomal protein L23 110 26 1 5 44 aompkzyqvdrlbcefghsnujxitw RplX [J] COG0198 Ribosomal protein L24 113 20 2 - 35 ------yqvdrlbcefghsnujxitw RpmA [J] COG0211 Ribosomal protein L27 114 20 2 - 35 ------yqvdrlbcefghsnujxitw RpmB [J] COG0227 Ribosomal protein L28 115 26 1 2 44 aompkzyqvdrlbcefghsnujxitw RpmC [J] COG0255 Ribosomal protein L29 116 26 1 7 46 aompkzyqvdrlbcefghsnujxitw RplC [J] COG0087 Ribosomal protein L3 117 22 5 3 39 aompkzyqvdrlb-efghsn-jx-t- RpmD [J] COG1841 Ribosomal protein L30/L7E 121 19 3 1 33 ------yqvd-lbcefghsnujxitw RpmF [J] COG0333 Ribosomal protein L32 123 20 2 - 40 ------yqvdrlbcefghsnujxitw RpmG [J] COG0267 Ribosomal protein L33 124 20 2 - 34 ------yqvdrlbcefghsnujxitw RpmH [J] COG0230 Ribosomal protein L34 126 20 2 1 34 ------yqvdrlbcefghsnujxitw RpmI [J] COG0291 Ribosomal protein L35 128 20 2 1 39 ------yqvdrlbcefghsnujxitw RpmJ [J] COG0257 Ribosomal protein L36 132 26 1 3 47 aompkzyqvdrlbcefghsnujxitw RplD [J] COG0088 Ribosomal protein L4 135 26 1 3 47 aompkzyqvdrlbcefghsnujxitw RplE [J] COG0094 Ribosomal protein L5 136 26 1 2 47 aompkzyqvdrlbcefghsnujxitw RplF [J] COG0097 Ribosomal protein L6 137 20 2 2 36 ------yqvdrlbcefghsnujxitw RplL [J] COG0222 Ribosomal protein L7/L12 139 19 3 5 35 ------yqvdrlbcefghsnujxit- RpsA [J] COG0539 Ribosomal protein S1 141 26 1 3 47 aompkzyqvdrlbcefghsnujxitw RpsJ [J] COG0051 Ribosomal protein S10 142 26 1 6 46 aompkzyqvdrlbcefghsnujxitw RpsK [J] COG0100 Ribosomal protein S11 143 26 1 4 49 aompkzyqvdrlbcefghsnujxitw RpsL [J] COG0048 Ribosomal protein S12 144 26 1 2 47 aompkzyqvdrlbcefghsnujxitw RpsM [J] COG0099 Ribosomal protein S13 145 26 1 4 50 aompkzyqvdrlbcefghsnujxitw RpsN [J] COG0199 Ribosomal protein S14 146 26 1 4 47 aompkzyqvdrlbcefghsnujxitw RpsO [J] COG0184 Ribosomal protein S15P/S13E 147 20 2 2 35 ------yqvdrlbcefghsnujxitw RpsP [J] COG0228 Ribosomal protein S16 148 26 1 2 46 aompkzyqvdrlbcefghsnujxitw RpsQ [J] COG0186 Ribosomal protein S17 150 20 2 4 36 ------yqvdrlbcefghsnujxitw RpsR [J] COG0238 Ribosomal protein S18 151 26 1 2 45 aompkzyqvdrlbcefghsnujxitw RpsS [J] COG0185 Ribosomal protein S19 153 26 1 4 47 aompkzyqvdrlbcefghsnujxitw RpsB [J] COG0052 Ribosomal protein S2 160 26 1 1 44 aompkzyqvdrlbcefghsnujxitw RpsC [J] COG0092 Ribosomal protein S3 162 26 1 5 49 aompkzyqvdrlbcefghsnujxitw RpsD [J] COG0522 Ribosomal protein S4 and related proteins 164 26 1 3 47 aompkzyqvdrlbcefghsnujxitw RpsE [J] COG0098 Ribosomal protein S5 165 20 2 1 35 ------yqvdrlbcefghsnujxitw RpsF [J] COG0360 Ribosomal protein S6 167 26 1 4 47 aompkzyqvdrlbcefghsnujxitw RpsG [J] COG0049 Ribosomal protein S7 168 26 1 4 47 aompkzyqvdrlbcefghsnujxitw RpsH [J] COG0096 Ribosomal protein S8 170 26 1 4 46 aompkzyqvdrlbcefghsnujxitw RpsI [J] COG0103 Ribosomal protein S9 172 20 2 2 36 ------yqvdrlbcefghsnujxitw Frr [J] COG0233 Ribosome recycling factor 178 17 7 1 45 ----k-yqv-rlbcefghsnuj-i-- TrmA [J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase 180 26 1 4 46 aompkzyqvdrlbcefghsnujxitw SerS [J] COG0172 Seryl-tRNA synthetase 182 26 1 4 50 aompkzyqvdrlbcefghsnujxitw ThrS [J] COG0441 Threonyl-tRNA synthetase 183 26 1 * 80 aompkzyqvdrlbcefghsnujxitw FusA [J] COG0480 Translation elongation and release factors (GTPases) 185 26 1 3 52 aompkzyqvdrlbcefghsnujxitw Efp [J] COG0231 Translation elongation factor P/translation initiation factor eIF-5A 188 26 1 5 49 aompkzyqvdrlbcefghsnujxitw InfB [J] COG0532 Translation initiation factor 2 (GTPase) 189 26 1 2 46 aompkzyqvdrlbcefghsnujxitw InfA [J] COG0361 Translation initiation factor IF-1 192 13 8 3 17 a-mpkzyqv---bc-f--s--j---- GCN3 [J] COG0182 Translation initiation factor eIF-2B alpha subunit 196 26 1 4 49 aompkzyqvdrlbcefghsnujxitw TrpS [J] COG0180 Tryptophanyl-tRNA synthetase 197 26 1 3 50 aompkzyqvdrlbcefghsnujxitw TyrS [J] COG0162 Tyrosyl-tRNA synthetase 199 26 1 4 45 aompkzyqvdrlbcefghsnujxitw ValS [J] COG0525 Valyl-tRNA synthetase 201 21 3 3 68 a-----yqvdrlbcefghsnujxitw SpoU [J] COG0566 rRNA methylases 202 21 6 9 54 aom-kzy-vdrlbcefghsnuj-i-- Sun [J] COG0144 tRNA and rRNA cytosine-C5-methylases 203 19 3 1 32 ------yqvdrlbcefghsnujxit- MiaA [J] COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase 205 19 3 2 50 ------yqvdrlbcefghsnujxit- PcnB [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase 216 26 1 4 46 aompkzyqvdrlbcefghsnujxitw RpoA [K] COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit 217 26 1 6 53 aompkzyqvdrlbcefghsnujxitw RpoB [K] COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) 218 26 1 9 63 aompkzyqvdrlbcefghsnujxitw RpoC [K] COG0086 DNA-directed RNA polymerase beta' subunit/160 kD subunit (split gene in archaea and Syn) 226 24 3 2 38 aompkzyqvdrlbcefghsnujx-t- RpoZ [K] COG1758 DNA-directed RNA polymerase subunit K/omega 233 19 4 5 48 -o----yqvd-lbcefghsnuj-itw VacB [K] COG0557 Exoribonucleases 236 24 3 * 309 aompkzyqvdrlbcefghsnuj-i-w WecD [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases 237 16 9 - 35 aompkz--vdrlb-e---s--j-it- TroR [K] COG1321 Mn-dependent transcriptional regulator 241 14 6 2 22 aompkzy-vd-lbc------u---t- - [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP 266 21 5 - 148 aompkz-qvdrlbcefghsnuj---- ArsR [K] COG0640 Predicted transcriptional regulators 278 20 7 - 57 aom-kz-q-drlb-efg-snujxit- Spo0J [K] COG1475 Predicted transcriptional regulators 292 19 6 * 74 ao-pkzy-vdrlbcefghs----i-w HepA [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family 293 26 1 2 48 aompkzyqvdrlbcefghsnujxitw NusG [K] COG0250 Transcription antiterminator 301 25 2 - 47 aompkz-qvdrlbcefghsnujxitw NusA [K] COG0195 Transcription terminator 302 20 6 - 307 aom-k--qvdrlbcefghsnuj---w AcrR [K] COG1309 Transcriptional regulator 314 16 8 - 73 ao-p-z-qvdrlbce-gh---j--t- NagC [K] COG1940 Transcriptional regulators 323 20 2 * 43 ------yqvdrlbcefghsnujxitw Rnc [K] COG0571 dsRNA-specific ribonuclease 327 26 1 * 61 aompkzyqvdrlbcefghsnujxitw Exo [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 333 16 8 - 21 aompkz-qvd-lbcefg-------t- SbcC [L] COG0419 ATPase involved in DNA repair 334 25 2 * 75 aompkzyqvdrlbcefghsnu-xitw HolB [L] COG0470 ATPase involved in DNA replication 344 23 2 5 63 ao-p--yqvdrlbcefghsnujxitw GyrA [L] COG0188 DNA gyrase (topoisomerase II) A subunit 345 23 2 7 62 ao-p--yqvdrlbcefghsnujxitw GyrB [L] COG0187 DNA gyrase (topoisomerase II) B subunit 348 18 5 5 34 -o----yqvd-lbcefghsn-jxit- MutL [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) 352 19 3 3 31 ------yqvdrlbcefghsnujxit- PolA [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains 355 26 1 3 47 aompkzyqvdrlbcefghsnujxitw DnaN [L] COG0592 DNA polymerase III beta subunit 358 21 4 3 63 a--p--yqvdrlbcefghsnujxit- DnaQ [L] COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonucleases 364 25 2 - 46 aompkz-qvdrlbcefghsnujxitw DnaG [L] COG0358 DNA primase (bacterial type) 366 18 6 2 27 aompkzyqvdrlbcefg-------t- SbcD [L] COG0420 DNA repair exonuclease 380 14 9 1 27 -ompkzyqv-r-b-e-g------i-w Nfo [L] COG0648 Endonuclease IV 401 25 2 - 219 aompkz-qvdrlbcefghsnujxitw XerC [L] COG0582 Integrase 403 22 5 2 47 aompkzyqv-rlb-efghsnuj-it- Ada [L] COG0350 Methylated DNA-protein cysteine methyltransferase 404 23 3 6 58 --m-kzyqvdrlbcefghsnujxitw TatD [L] COG0084 Mg-dependent DNase 405 12 11 1 24 -om-k-yq----b--f-h-nuj---w - [L] COG1525 Micrococcal nuclease (thermonuclease) homologs 407 19 6 7 42 -o-p--yqvd-lbcefghsn-jxit- MutS [L] COG0249 MutS-like ATPases involved in mismatch repair, family 2 411 24 3 * 198 aomp-zyqvdrlbcefghsnujxit- MutT [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes 422 25 2 2 47 aompkzyqvdrlbcefghsnujxit- Nth [L] COG0177 Predicted EndoIII-related endonuclease 443 13 9 - 88 -ompk--qvdr--ce---s-u---t- - [L] COG0675 Predicted transposases 454 26 1 5 62 aompkzyqvdrlbcefghsnujxitw RecA [L] COG0468 RecA/RadA recombinase 471 16 6 4 31 -o----y--dr-bcefghsnujx-t- RnhA [L] COG0328 Ribonuclease HI 472 25 2 2 39 aompkzyqvdrlbcefghsnujxit- RnhB [L] COG0164 Ribonuclease HII 474 20 2 2 50 ------yqvdrlbcefghsnujxitw Ssb [L] COG0629 Single-stranded DNA-binding protein 475 22 5 - 48 aompk--qvd-lbcefghsnujxit- RecJ [L] COG0608 Single-stranded DNA-specific exonuclease 481 23 4 - 78 -omp--yqvdrlbcefghsnujxitw UvrD [L] COG0210 Superfamily I DNA and RNA helicases 482 15 9 * 42 aompk-yqv-r--cef--s-u----w - [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits 483 21 6 * 165 a-mp--yq-drlbcefghsnujx-tw SrmB [LKJ] COG0513 Superfamily II DNA and RNA helicases 486 26 1 2 59 aompkzyqvdrlbcefghsnujxitw TopA [L] COG0550 Topoisomerase IA 501 18 9 - 34 ao-pkz-qvdrl-c--gh-nujx-t- - [L] COG1573 Uracil-DNA glycosylase 502 18 6 - 40 aompk---v--lb-efghsnu--itw TopA [L] COG0551 Zn-finger domain associated with topoisomerase type I 503 20 7 - 92 -ompk--q-dr-bcefg-snujxitw Soj [D] COG1192 ATPases involved in chromosome partitioning 504 22 4 4 55 aompkzyqvdr-bcefghsnujx--- Mrp [D] COG0489 ATPases involved in chromosome partitioning 508 23 4 - 57 aompk--qvdrlbcefghsnujx-tw FtsZ [D] COG0206 Cell division GTPase 514 19 6 * 41 aompk-yqvdrlbc-f--sn-j--tw Smc [D] COG1196 Chromosome segregation ATPases 516 17 7 2 46 a-mp--yqv---b-efghs-ujxit- MreB [D] COG1077 HSP70 class molecular chaperones involved in cell morphogenesis 517 18 7 - 32 -om-k-yqvdr-bcefghsnuj---- CrcB [D] COG0239 Integral membrane protein possibly involved in chromosome condensation 520 19 3 2 34 ------yqvd-lbcefghsnujxitw GidA [D] COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division 521 18 6 2 36 ----k-yqvdr-bcefghsnujxi-- Maf [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation 523 26 1 3 79 aompkzyqvdrlbcefghsnujxitw MesJ [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control 539 17 4 8 34 ------yqvd--b-efghsnujxitw Lon [O] COG0466 ATP-dependent Lon protease, bacterial type 540 20 2 7 50 ------yqvdrlbcefghsnujxitw HflB [O] COG0465 ATP-dependent Zn proteases 541 19 3 3 32 ------yqvdrlbcefghsnujxit- ClpX [O] COG1219 ATP-dependent protease Clp, ATPase subunit 544 21 3 5 81 --m---yqvdrlbcefghsnujxitw ClpA [O] COG0542 ATPases with chaperone activity, ATP-binding subunit 547 26 1 * 80 aompkzyqvdrlbcefghsnujxitw GroL [O] COG0459 Chaperonin GroEL (HSP60 family) 548 20 2 2 38 ------yqvdrlbcefghsnujxitw GroS [O] COG0234 Co-chaperonin GroES (HSP10) 550 18 6 2 33 -om---y--drlbcefghsnuj--tw - [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase 563 20 7 8 57 aom-k-y-vdrlbcefghsn-jx-t- GrxC [O] COG0695 Glutaredoxin and related proteins 576 24 3 * 82 aompkzyqvdrlbcefghsnujx-t- HflC [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs 577 26 1 3 47 aompkzyqvdrlbcefghsnujxitw QRI7 [O] COG0533 Metal-dependent proteases with possible chaperone activity 578 23 4 * 93 -omp--yqvdrlbcefghsnujxitw DnaK [O] COG0443 Molecular chaperone 579 19 7 * 52 aompkzyqvdr-bcefg-s--jx--- IbpA [O] COG0071 Molecular chaperone (small heat shock protein) 580 23 4 2 40 -omp--yqvdrlbcefghsnujxitw GrpE [O] COG0576 Molecular chaperone GrpE (heat shock protein) 582 23 4 * 115 -omp--yqvdrlbcefghsnujxitw DnaJ [O] COG0484 Molecular chaperones (contain C-terminal Zn finger domain) 587 17 5 4 68 ------yqvd-lbcefghsnujx-t- SurA [O] COG0760 Parvulin-like peptidyl-prolyl isomerase 588 18 6 4 38 -om---y--drlbcefghsnuj--tw MsrA [O] COG0225 Peptide methionine sulfoxide reductase 589 17 7 * 58 -om---y--drlbcefghsnuj--t- PpiB [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family 591 24 3 * 54 aompkzyqvdrlbcefghs-ujxit- AhpC [O] COG0450 Peroxiredoxin 592 18 7 - 40 -o-p-zyqvdr-bcefghsnuj---- Bcp [O] COG1225 Peroxiredoxin 606 20 6 * 72 aompkzyqv-r-b-efghs-ujx-t- HslV [O] COG0638 Proteasome protease subunit 617 17 7 * 68 ao---zyq-drlbc-fg-snuj---w AprE [O] COG1404 Subtilisin-like serine proteases 618 26 1 * 239 aompkzyqvdrlbcefghsnujxitw TrxA [OC] COG0526 Thiol-disulfide isomerase and thioredoxins 620 26 1 - 76 aompkzyqvdrlbcefghsnujxitw TrxB [O] COG0492 Thioredoxin reductase 623 21 4 * 81 -om---yqvdrlbcefghsnujxit- DegQ [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain 633 21 5 4 76 aompkzyq-drlbcefghsnuj---- HtpX [O] COG0501 Zn-dependent protease with chaperone function 668 23 4 4 43 -ompkzyqvdrlbcefghsnuj-it- GlmS [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains 671 25 2 * 238 aompkzyqvdrlbcefghsnujx-tw WcaA [M] COG0463 Glycosyltransferases involved in cell wall biogenesis 692 22 5 * 162 aompk-yqvdrlbcefghsnuj--t- WcaG [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 693 19 8 9 56 aompkzyq-dr-bc-f-hsnuj--t- GCD1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylases involved in lipopolysaccharide biosynthesis/translation initiation factor eIF2B subunits 716 24 3 * 260 aompkzyqvdrlbcefghsnujx-t- RfaG [M] COG0438 Predicted glycosyltransferases 718 24 3 2 52 aompkz-qvdrlbcefghsnujxit- - [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1 722 16 4 2 40 ------yqvd---cefghsnujxit- - [M] COG0729 Predicted outer membrane protein 728 17 7 - 29 a-m-kzyq----b-efghsnujxi-- GutQ [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation 745 22 5 - 80 aompkz-qvdrlbcefg-snujx-t- MscS [M] COG0668 Small-conductance mechanosensitive channel 763 21 4 2 56 --m-k-yqvdrlbcefghsnujxit- Rfe [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase 842 20 2 2 35 ------yqvdrlbcefghsnujxitw LepA [N] COG0481 Membrane GTPase LepA 850 23 4 - 56 aompkz-qvdr-bcefghsnujxit- SppA [NO] COG0616 Periplasmic serine proteases (ClpP class) 872 26 1 2 46 aompkzyqvdrlbcefghsnujxitw SecY [N] COG0201 Preprotein translocase subunit SecY 874 20 2 4 40 ------yqvdrlbcefghsnujxitw YidC [N] COG0706 Preprotein translocase subunit YidC 885 25 2 4 68 aompkzyqvdrlbcefghsnujxit- LepB [N] COG0681 Signal peptidase I 886 19 7 - 33 aom-kz-qvd-lbcefghsnuj---- PppA [N] COG1989 Signal peptidase, cleaves prepilin-like proteins 888 26 1 2 44 aompkzyqvdrlbcefghsnujxitw Ffh [N] COG0541 Signal recognition particle GTPase 889 26 1 4 46 aompkzyqvdrlbcefghsnujxitw FtsY [N] COG0552 Signal recognition particle GTPase 901 22 5 - 46 aom-kz-qvdrlbcefgh-nujxit- ZnuA [P] COG0803 ABC-type Mn/Zn transport system, periplasmic Mn/Zn-binding (lipo)protein (surface adhesin A) 902 21 6 - 41 aom-kz-qvd-lbcefgh-nujxit- ZnuC [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component 903 22 5 - 49 aom-kz-qvdrlbcefgh-nujxit- ZnuB [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components 914 21 6 - 38 aom-kz-qvdrlbcefghs-uj--tw PstB [P] COG1117 ABC-type phosphate transport system, ATPase component 915 21 6 - 46 aom-kz-qvdrlbcefghs-uj--tw PstS [P] COG0226 ABC-type phosphate transport system, periplasmic component 916 21 6 - 34 aom-kz-qvdrlbcefghs-uj--tw PstA [P] COG0581 ABC-type phosphate transport system, permease component 917 21 6 - 34 aom-kz-qvdrlbcefghs-uj--tw PstC [P] COG0573 ABC-type phosphate transport system, permease component 924 15 11 3 23 a---kzyq-dr-bcefg-s-uj---- CysC [P] COG0529 Adenylylsulfate kinase and related kinases 926 17 9 8 38 a-mp--yqvdrlbcef--sn-j---w AmtB [P] COG0004 Ammonia permeases 934 14 7 * 25 aompk-yqv---bce-gh------t- ECM27 [P] COG0530 Ca2+/Na+ antiporter 939 24 3 2 89 aompkzyqvdrlbcefgh-nuj-itw ZntA [P] COG2217 Cation transport ATPases 943 15 8 5 28 ----k-yqvdrlb-ef-hsnuj---- CzcD [P] COG1230 Co/Zn/Cd efflux system component 944 16 8 2 30 ao-p-zyqvd-lbc-f-h-nu----w CopZ [P] COG2608 Copper chaperone 949 17 8 7 50 -om-k-yq-d-lbcefghsnu--i-- CitT [P] COG0471 Di- and tricarboxylate transporters 964 20 6 - 46 aom-kz-qvdrlbcefgh-nu---tw TrkA [P] COG0569 K+ transport systems, NAD-binding component 968 22 5 1 60 a-mpkzyq-drlbcefghsnujx-t- KefB [P] COG0475 Kef-type K+ transport systems, membrane components 969 24 2 * 79 aompkzyqvdrlbcefghsnujx--w Kch [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component 974 18 8 - 47 a-m-k-yqvdrlbcefghs-uj---- CorA [P] COG0598 Mg2+ and Co2+ transporters 998 20 7 - 50 aompkz-qvdrlbcefg-s--j--tw PhoU [P] COG0704 Phosphate uptake regulator 999 18 9 8 50 aompk-y-vdr-b-efgh-nuj-i-- PitA [P] COG0306 Phosphate/sulphate permeases 1002 21 6 * 36 aom-kzyqvdrlbcefgh--ujx-t- MMT1 [P] COG0053 Predicted Co/Zn/Cd cation transporters 1003 14 9 * 23 -om-kzyqvdr---ef---nu---t- - [P] COG0428 Predicted divalent heavy-metal cations transporter 1015 21 6 5 95 aomp--yq-drlbcefghsnujx-t- PspE [P] COG0607 Rhodanese-related sulfurtransferases 1021 22 5 3 49 -omp-zyq-drlbcefghsnujxit- SodA [P] COG0605 Superoxide dismutase 1023 20 6 - 37 aom-kzyqvd-lbcefgh-nu---tw TrkG [P] COG0168 Trk-type K+ transport systems, membrane components 1048 20 7 - 334 aom-k-y-vdrlbcefghs-ujx-t- CheY [T] COG0784 CheY-like receiver domains 1050 20 6 * 79 aompkzy-vd-lbcefghsnuj---- ApaH [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases 1056 14 10 - 64 aom---yqvdr-bcefg----j---- FhlA [T] COG2203 GAF domain 1089 14 8 * 43 ---p--yq-drlbc-f--s-uj-i-w PTC1 [T] COG0631 Protein serine/threonine phosphatases 1091 18 8 2 42 aom---yq-drlbcefghsnuj---- Wzb [T] COG0394 Protein-tyrosine-phosphatase 1093 11 4 - 46 aompkzyqv----c-------j---- RAD55 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction 1102 22 5 2 549 aom---yqvdrlbcefghsnujxit- BaeS [T] COG0642 Sensory transduction histidine kinases 1105 18 8 * 297 -o-p-zyq-drlbcefghs--j-i-w SPS1 [T] COG0515 Serine/threonine protein kinases 1112 20 6 - 116 aompkzyq-drlbcefgh-n-jx--- UspA [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins 1113 18 4 * 90 ------yqvdrlbcefghsnuj-it- Crp [T] COG0664 cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 1119 16 9 6 30 -o-p-zyq-drlb-efg-sn-jx--- AcnA [C] COG1048 Aconitase A 1126 16 5 2 35 aompkzyqv--lb-efgh---j---- EutG [C] COG1454 Alcohol dehydrogenase IV 1151 22 4 6 51 aomp-zyqvdrlbcefghsnujx--- GltA [C] COG0372 Citrate synthase 1160 16 8 - 30 -o-p-zyq-dr-bc-fg-snujx--- QcrB [C] COG1290 Cytochrome b subunit of the bc complex 1161 16 9 - 34 ao-p---q--rlbcefgh--ujxi-- CydA [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 1170 16 7 2 56 aompkzyqv-r--cef--sn-j---- FixC [C] COG0644 Dehydrogenases (flavoproteins) 1172 19 6 8 77 -o-p-zy--drlbcefghsn-jxi-w AceF [C] COG0508 Dihydrolipoamide acyltransferases 1173 23 4 8 97 aomp-zyqvdrlbcefghsn-jxi-w Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes 1177 17 4 - 29 ------yqv-rlbcefghsnujx--w AtpB [C] COG0356 F0F1-type ATP synthase a subunit 1178 17 4 3 31 ------yqv-rlbcefghsnujx--w AtpA [C] COG0056 F0F1-type ATP synthase alpha subunit 1180 17 4 3 31 ------yqv-rlbcefghsnujx--w AtpD [C] COG0055 F0F1-type ATP synthase beta subunit 1181 26 1 * 53 aompkzyqvdrlbcefghsnujxitw AtpE [C] COG0636 F0F1-type ATP synthase c subunit/Archaeal/vacuolar-type H+-ATPase subunit K 1182 17 4 2 31 ------yqv-rlbcefghsnujx--w AtpH [C] COG0712 F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) 1183 17 4 2 30 ------yqv-rlbcefghsnujx--w AtpC [C] COG0355 F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) 1184 17 4 1 32 ------yqv-rlbcefghsnujx--w AtpG [C] COG0224 F0F1-type ATP synthase gamma subunit 1185 18 7 8 100 ao-p-zyq-dr-bcefghsnuj---- GlcD [C] COG0277 FAD/FMN-containing dehydrogenases 1193 15 8 3 49 ao----yq-dr--cefgh-n-jxi-- Fdx [C] COG0633 Ferredoxin 1202 19 5 2 36 aompkzyqvdr--cef--snujx--- NuoI [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) 1209 17 7 4 31 -o---zy--dr-bcefghsnujxi-- FumC [C] COG0114 Fumarase 1213 22 4 5 37 a-m---yqvdrlbcefghsnujxitw GpsA [C] COG0240 Glycerol 3-phosphate dehydrogenase 1215 21 6 8 33 ao-pkzyqvdrlbcefghs--j--tw GlpK [C] COG0554 Glycerol kinase 1217 17 9 * 50 -o-pkzy-vdrlb-efgh---j--tw UgpQ [C] COG0584 Glycerophosphoryl diester phosphodiesterase 1226 22 5 2 41 -ompkzyq-dr-bcefghsnujxi-w Ppa [C] COG0221 Inorganic pyrophosphatase 1228 17 8 5 28 ao-p-zyqvdrlbcef-h--uj---- Icd [C] COG0538 Isocitrate dehydrogenases 1230 20 6 2 44 aompkzy--drlbcefgh-n-jx-t- LldD [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases 1232 16 11 3 57 ---pkzyq---lbcefgh-nuj--t- LdhA [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases 1235 23 4 9 45 aomp-zyqvdrlbce-ghs-ujxitw Mdh [C] COG0039 Malate/lactate dehydrogenases 1236 21 5 7 42 ao-pkzy-vdrlbcefghsnujx--- SfcA [C] COG0281 Malic enzyme 1241 19 7 * 202 -omp-zyq-drlbcefgh-nuj---w PutA [C] COG1012 NAD-dependent aldehyde dehydrogenases 1245 13 6 2 21 ------yqvdr--cef--snujx--- NuoG [C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) 1247 18 6 3 26 ao-pkzyqvdr--cef--snujx--- NuoB [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 1249 18 6 2 27 ao-pkzyqvdr--cef--snujx--- NuoC [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 1250 18 6 4 27 ao-pkzyqvdr--cef--snujx--- NuoD [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 1270 16 10 8 39 -o--kz-q-dr-b-efg-s-ujxit- GltP [C] COG1301 Na+/H+-dicarboxylate symporters 1279 19 6 2 37 ao----yqv-rlb-efgh-nujxitw IscU [C] COG0822 NifU homologs involved in Fe-S cluster formation 1285 21 5 2 89 aompkz-qvdrlbcefghsnuj---- NfnB [C] COG0778 Nitroreductase 1299 18 8 2 94 -o-p-zyqvdrlbcefg-s-uj--t- Tas [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) 1305 18 8 - 63 aompkzyqv-rlbce-g---uj--t- PorA [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit 1306 18 8 - 60 aompkzyqv-rlbce-g---uj--t- PorB [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit 1308 17 9 - 55 aompkz-qv-rlbce-g---uj--t- PorG [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit 1310 16 8 3 35 -o-p-zyq-dr-bc-fg-snujx--- QcrA [C] COG0723 Rieske Fe-S protein 1314 21 6 3 41 aomp-zyq-dr-bcefghsnujxi-- FrdB [C] COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein 1315 17 8 2 28 ao-p-zy--dr-b-efg-snujxi-- SdhC [C] COG2009 Succinate dehydrogenase/fumarate reductase cytochrome b subunit 1316 23 4 4 54 aomp-zyqvdrlbcefghsnujxi-- SdhA [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunits 1317 21 6 7 38 aomp-zyq-dr-bcefghsnujxi-- SucD [C] COG0074 Succinyl-CoA synthetase alpha subunit 1318 21 6 7 34 aomp-zyq-dr-bcefghsnujxi-- SucC [C] COG0045 Succinyl-CoA synthetase beta subunit 1335 25 2 3 43 aompkzyqvdrlbcefghsnuj-itw Pgk [G] COG0126 3-phosphoglycerate kinase 1337 16 6 4 35 ------yqvdrlbce-ghs--j-itw PfkA [G] COG0205 6-phosphofructokinase 1340 16 6 4 42 ------y-v-rlbcefghsnuj-it- NagB [G] COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase 1344 23 4 - 175 aompkz-qvdrlbcefghsnuj--tw MalK [G] COG1130 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component 1356 23 4 * 48 aom-kzyqvdrlbcefghsnujx-t- SuhB [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family 1362 16 6 - 41 ------y-vdrlbcefghsn-jx-t- BglX [G] COG1472 Beta-glucosidase-related glycosidases 1377 25 2 2 51 aompkzyqvdrlbcefghsnuj-itw Eno [G] COG0148 Enolase 1382 17 5 - 42 ------yqvdrlbcefgh-nuj--tw Fba [G] COG0191 Fructose/tagatose bisphosphate aldolase 1390 18 4 4 31 ------yqvdrlbcefghsnuj-it- Zwf [G] COG0364 Glucose-6-phosphate 1-dehydrogenase 1391 23 4 2 41 -omp-zyqvdrlbcefghsnuj-itw Pgi [G] COG0166 Glucose-6-phosphate isomerase 1394 25 2 7 61 aompkzyqvdrlbcefghsnuj-itw GapA [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase 1416 21 5 2 40 --mp--yqvdrlbcefghsnuj-itw Rpe [G] COG0036 Pentose-5-phosphate-3-epimerase 1418 24 3 6 215 aompkzyqvd-lbcefghsnujxit- RhaT [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily 1419 26 1 * 925 aompkzyqvdrlbcefghsnujxitw ProP [GEPR]COG0477 Permeases of the major facilitator superfamily 1420 21 6 1 43 aompkz-qvdr-bcefg-snujx-t- PpsA [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase 1427 26 1 5 94 aompkzyqvdrlbcefghsnujxitw CpsG [G] COG1109 Phosphomannomutase 1447 21 5 2 32 aompkzyqvdrlbcefg-snuj---- - [G] COG0063 Predicted sugar kinase 1448 15 10 * 30 ao--kzyqv-rlb-ef----ujx--- NagD [G] COG0647 Predicted sugar phosphatases of the HAD superfamily 1455 23 4 8 53 -ompkzy-vdrlbcefghsnuj-itw PykF [G] COG0469 Pyruvate kinase 1456 19 7 2 31 aompkzy--d-l-cefghsn-j-it- RpiA [G] COG0120 Ribose 5-phosphate isomerase 1460 21 5 5 50 aompkzyqv-rlb-efghs-ujx--w AraD [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases 1470 18 8 1 40 --mp--yqvdrlbcefgh-nuj-i-- MipB [G] COG0176 Transaldolase 1471 23 4 3 57 --mpkzyqvdrlbcefghsnuj-itw TktA [G] COG0021 Transketolase 1475 25 2 2 45 aompkzyqvdrlbcefghsnuj-itw TpiA [G] COG0149 Triosephosphate isomerase 1487 19 8 - 32 ---pkzy-vdrlbcefghsnuj-i-- AroB [E] COG0337 3-dehydroquinate synthetase 1488 20 6 - 36 aom-k-yqvdrlbcefghsnuj---- LeuC [E] COG0065 3-isopropylmalate dehydratase large subunit 1489 19 7 - 35 a-m-k-yqvdrlbcefghsnuj---- LeuD [E] COG0066 3-isopropylmalate dehydratase small subunit 1491 18 8 2 30 ---pkzyqvd-lbcefghsnuj---- MetF [E] COG0685 5,10-methylenetetrahydrofolate reductase 1493 23 4 - 39 aompkzyqvdrlbcefghsnuj-i-- AroA [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase 1499 19 7 - 91 ao-pkz-qvd-lb-efgh--uj-itw OppF [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 1500 19 7 - 87 ao-pkz-qvd-lb-efgh--uj-itw DppD [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 1501 21 6 - 173 ao-pkz-qvdrlbcefgh--uj-itw OppA [EP] COG0747 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components 1502 21 6 - 125 ao-pkz-qvdrlbcefgh--uj-itw DppB [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 1503 21 6 - 124 ao-pkz-qvdrlbcefgh--uj-itw DppC [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 1508 15 10 - 51 ao---z--vd-l--efgh-nuj--tw PotB [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I 1509 15 10 - 51 ao---z--vd-l--efgh-nuj--tw PotC [E] COG1177 ABC-type spermidine/putrescine transport system, permease component II 1511 19 7 - 29 aom---yqvdrlbcefghsnuj---- HisG [E] COG0040 ATP phosphoribosyltransferase (histidine biosynthesis) 1512 20 6 - 37 a-m-kzyqvdrlbcefghsnuj---- IlvH [E] COG0440 Acetolactate synthase, small subunit 1513 20 6 - 38 a-m-kzyqvdrlbcefghsnuj---- ArgB [E] COG0548 Acetylglutamate kinase 1514 20 6 - 30 a-m-kzyqvdrlbcefghsnuj---- ArgC [E] COG0002 Acetylglutamate semialdehyde dehydrogenase 1515 22 5 * 108 a-mpkzyqvdrlb-efghsnujxi-- ArgE [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases 1521 19 7 * 170 aomp-zy---rlbcefghs--jxi-w PotE [E] COG0531 Amino acid transporters 1525 22 4 - 41 aompkzyqvdrlbcefghsnuj---- TrpD [E] COG0547 Anthranilate phosphoribosyltransferase 1526 22 4 - 69 aompkzyqvdrlbcefghsnuj---- TrpE [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I 1527 22 4 - 51 aompkzyqvdrlbcefghsnuj---- PabA [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II 1536 20 6 1 31 aomp--yqvdrlbcefghsnuj---- ArgH [E] COG0165 Argininosuccinate lyase 1537 20 6 1 30 aomp--yqvdrlbcefghsnuj---- ArgG [E] COG0137 Argininosuccinate synthase 1542 24 3 - 44 aompkzyqvdrlbcefghsnujxi-- Asd [E] COG0136 Aspartate-semialdehyde dehydrogenase 1544 24 3 - 56 aompkzyqvdrlbcefghsnujxi-- LysC [E] COG0527 Aspartokinases 1548 20 6 3 66 aom---yqvdrlbcefghsnujx--- IlvE [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase 1551 20 6 3 41 aomp--yqvdrlbcefghsnuj---- CarB [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) 1552 20 6 2 36 aomp--yqvdrlbcefghsnuj---- CarA [EF] COG0505 Carbamoylphosphate synthase small subunit 1554 20 6 - 43 aomp-zyqvdrlb-efghsnuj---- PheA [E] COG1605 Chorismate mutase 1555 23 4 - 38 aompkzyqvdrlbcefghsnuj-i-- AroC [E] COG0082 Chorismate synthase 1556 19 7 4 72 -o-pkzy-vdrlbcefghsnuj---- MetC [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases 1557 20 5 5 52 ao----yqvdrlbcefgh-nujxit- NifS [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes 1558 20 6 * 63 -o-pkzyqvdrlbcefghsnuj---- CysK [E] COG0031 Cysteine synthase 1561 19 7 4 45 a-mp--yqvdrlbcefghsnuj---- LysA [E] COG0019 Diaminopimelate decarboxylase 1564 22 5 - 57 aompkz-qv-rlbcefghsnujxi-- DapA [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase 1565 20 6 - 49 a-m-kzyqvdrlbcefghsnuj---- IlvD [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase 1571 17 5 2 26 ------yqvdrlbcefghsnuj--t- ProA [E] COG0014 Gamma-glutamyl phosphate reductase 1573 17 5 2 28 ------yqvdrlbcefghsnuj--t- ProB [E] COG0263 Glutamate 5-kinase 1575 17 10 3 44 ao-pkzy-vd--bcef-h-nuj-i-- GdhA [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase 1577 16 9 2 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0067 Glutamate synthase domain 1 1578 16 9 4 30 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0069 Glutamate synthase domain 2 1579 16 9 3 26 a-m---yqvdrlbcefg-s-uj---- GltB [E] COG0070 Glutamate synthase domain 3 1581 19 7 - 30 aom---yqvdrlbcefghsnuj---- HisH [E] COG0118 Glutamine amidotransferase 1582 23 3 * 64 aompkzyqvdrlbcefghsnujx--- GlnA [E] COG0174 Glutamine synthase 1584 19 8 4 34 -o-pkzyqvdrlbcefg-sn-j-i-- GcvH [E] COG0509 Glycine cleavage system H protein (lipoate-binding) 1585 16 10 5 48 -o-pkzyqvdr-bcef--sn-j---- GcvT [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase) 1586 16 10 2 25 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain 1587 16 10 2 24 -o-pkzyqvdr-bcef--sn-j---- GcvP [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain 1588 26 1 2 53 aompkzyqvdrlbcefghsnujxitw GlyA [E] COG0112 Glycine hydroxymethyltransferase 1589 21 6 8 120 ao-pkzyq--rlbcefghsnuj-it- DadA [E] COG0665 Glycine/D-amino acid oxidases (deaminating) 1591 19 7 - 31 aom---yqvdrlbcefghsnuj---- HisD [E] COG0141 Histidinol dehydrogenase 1592 13 9 - 24 a-mpk-yqvdrlb-e-g--------- HIS2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family 1594 22 4 - 54 aompkzyqvdrlbcefghsnuj---- HisC [E] COG0079 Histidinol-phosphate aminotransferase/Tyrosine aminotransferase 1597 22 4 - 43 aompkzyqvdrlbcefghsnuj---- ThrA [E] COG0460 Homoserine dehydrogenase 1598 19 7 - 30 -ompkzyqvdrlbce-ghs-uj---- ThrB [E] COG0083 Homoserine kinase 1600 19 7 - 28 aom---yqvdrlbcefghsnuj---- HisB [E] COG0131 Imidazoleglycerol-phosphate dehydratase 1601 19 7 - 30 aom---yqvdrlbcefghsnuj---- HisF [E] COG0107 Imidazoleglycerol-phosphate synthase 1602 22 4 - 34 aompkzyqvdrlbcefghsnuj---- TrpC [E] COG0134 Indole-3-glycerol phosphate synthase 1603 20 6 9 46 a-m-k-yqvdrlbcefghsnujx--- LeuB [E] COG0473 Isocitrate/isopropylmalate dehydrogenase 1604 19 7 1 58 a-mpk-yqvdr-bcefghsnuj---- LeuA [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases 1605 19 7 - 31 a-m-k-yqvdrlbcefghsnuj---- IlvC [EH] COG0059 Ketol-acid reductoisomerase 1617 20 7 - 40 a-mpkzyqv-rlb-efghsnuj-i-- MetE [E] COG0620 Methionine synthase II (cobalamin-independent) 1624 19 8 8 48 ---pkzyqvdrlbcefg-s-ujx-t- GltD [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases 1627 22 5 * 79 aompkzyq-d--bcefghsnujxit- PutP [EHR] COG0591 Na+/proline, Na+/panthothenate symporters and related permeases 1630 11 10 - 12 -o----y-vdrlb--f-h--uj---- MET17 [E] COG2873 O-acetylhomoserine sulfhydrylase 1632 24 3 - 42 aompkzyqvdrlbcefghsnuj--tw ArgF [E] COG0078 Ornithine carbamoyltransferase 1634 22 4 8 87 aompkzyqvdrlbcefghsnuj---- ArgD [E] COG0160 PLP-dependent aminotransferases 1635 25 2 * 123 aompkzyqvdrlbcefghsnujxit- AvtA [E] COG0436 PLP-dependent aminotransferases 1639 21 5 5 61 aompkzyqvdrlbcefghs-uj---- SerA [E] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases 1640 19 7 - 28 aom---yqvdrlbcefghsnuj---- HisI [E] COG0139 Phosphoribosyl-AMP cyclohydrolase 1641 18 6 - 27 -om---yqvdrlbcefghsnuj---- HisI [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase 1642 22 5 - 33 aompkzyqvd-lbcefghsnuj-i-- TrpF [E] COG0135 Phosphoribosylanthranilate isomerase 1643 19 7 - 28 aom---yqvdrlbcefghsnuj---- HisA [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 1654 20 6 2 31 aomp--yqvdrlbcefghsnuj---- PheA [E] COG0077 Prephenate dehydratase 1655 21 5 - 32 aomp-zyqvdrlbcefghsnuj---- TyrA [E] COG0287 Prephenate dehydrogenase 1660 20 7 4 37 --mp-zyqvdrlbcefghsnuj--t- ProC [E] COG0345 Pyrroline-5-carboxylate reductase 1663 21 5 3 54 -om-kzy-vdrlbcefghs-uj-itw CsdB [E] COG0520 Selenocysteine lyase 1668 17 8 2 30 aompkzyqvd-lbc-fg---uj---- - [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase 1669 23 4 - 45 aompkzyqvdrlbcefghsnuj-i-- AroE [E] COG0169 Shikimate 5-dehydrogenase 1670 17 5 - 33 ------yqvdrlbcefghsnuj-i-- AroK [E] COG0703 Shikimate kinase 1671 17 9 9 33 a-mpkzyqvdr-b-ef--snuj---- SpeE [E] COG0421 Spermidine synthase 1675 21 5 4 103 a-mpkzyqvdrlbcefghsnuj---- IlvB [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] 1677 19 6 4 47 -o-p-zy-vdrlbcefghsnujx--- IlvA [E] COG1171 Threonine dehydratase 1678 19 7 5 88 ao-pkzy-vdrlb-efghsn-j---w Tdh [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 1679 22 4 - 48 aompkzyqvdrlbcefghsnuj---- ThrC [E] COG0498 Threonine synthase 1683 23 4 - 35 aompkzyqvdrlbcefghsnuj-i-- TrpA [E] COG0159 Tryptophan synthase alpha chain 1684 21 6 - 32 aom-k-yqvdrlbcefghsnuj-i-- TrpB [E] COG0133 Tryptophan synthase beta chain 1695 26 1 * 84 aompkzyqvdrlbcefghsnujxitw PepP [E] COG0006 Xaa-Pro aminopeptidase 1700 16 10 6 41 aom---yqvd-lbce-gh--uj--t- UshA [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases 1702 19 5 4 29 ao-p--yqvdrlbcefghsnuj---- PurH [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 1704 20 6 2 55 -om-kzy-vdrlbcefgh-nuj--tw Apt [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins 1709 23 4 * 57 ao--k-yqvdrlbcefghsnujxitw Adk [F] COG0563 Adenylate kinase and related kinases 1710 21 5 2 42 aompk-yqvdrlbcefghsnuj---- PurB [F] COG0015 Adenylosuccinate lyase 1711 21 5 2 35 aompk-yqvdrlbcefghsnuj---- PurA [F] COG0104 Adenylosuccinate synthase 1714 21 5 2 34 aompkzyqvdrlbcefg-snuj---- PyrB [F] COG0540 Aspartate carbamoyltransferase, catalytic chain 1715 26 1 3 44 aompkzyqvdrlbcefghsnujxitw PyrG [F] COG0504 CTP synthase (UTP-ammonia lyase) 1716 14 9 5 22 -o---zy-vdrlb-e-gh---j--tw Cdd [F] COG0295 Cytidine deaminase 1719 18 8 2 53 aompkzyqvd--bcef-hs-uj---- SsnA [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases 1720 16 6 5 36 ------yq-drlbcefghsn-jxi-- - [FJ] COG0590 Cytosine/adenosine deaminases 1726 17 8 2 25 -omp-z-qvdrlbce-gh---j--tw DeoC [F] COG0274 Deoxyribose-phosphate aldolase 1727 25 2 7 74 aompkzyq-drlbcefghsnujxitw Hit [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases 1729 19 7 7 44 aompkzyqvdrlbcef--s-uj---- PyrC [F] COG0044 Dihydroorotase 1730 22 4 4 42 aompkzyqvdrlbcefghsnuj---- PyrD [F] COG0167 Dihydroorotate dehydrogenase 1731 16 5 - 31 ------yqvdr-bcefghsnujx--- GppA [FP] COG0248 Exopolyphosphatase 1732 18 6 2 29 -o-p--yqvdrlbcefghsnuj---- PurN [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN 1736 24 3 2 52 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0518 GMP synthase - Glutamine amidotransferase domain 1737 24 3 1 37 aompkzyqvdrlbcefghsnuj-it- GuaA [F] COG0519 GMP synthase - PP-ATPase domain 1738 21 5 3 32 aompk-yqvdrlbcefghsnuj---- PurF [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase 1739 19 3 * 39 ------yqvdrlbcefghsnujxi-w Gmk [F] COG0194 Guanylate kinase 1741 23 4 4 90 -ompkzyqvdrlbcefghsnuj-it- GuaB [F] COG0516 IMP dehydrogenase/GMP reductase 1744 23 4 6 38 aompkzyq-dr-bcefghsnujxit- Ndk [F] COG0105 Nucleoside diphosphate kinase 1748 23 4 3 40 aompkzyqvdrlbcefghsnuj-i-- PyrE [F] COG0461 Orotate phosphoribosyltransferase 1750 22 4 2 36 aompkzyqvdrlbcefghsnuj---- PyrF [F] COG0284 Orotidine-5'-phosphate decarboxylase 1752 21 5 2 35 aompk-yqvdrlbcefghsnuj---- PurD [F] COG0151 Phosphoribosylamine-glycine ligase 1753 21 5 2 33 aompk-yqvdrlbcefghsnuj---- PurM [F] COG0150 Phosphoribosylaminoimidazol (AIR) synthetase 1754 17 7 - 26 -o-p--yqvdrlbcefghsn-j---- PurK [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 1755 22 4 2 35 aompk-yqvdrlbcefghsnujx--- PurC [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase 1756 21 5 1 32 aompk-yqvdrlbcefghsnuj---- PurE [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase 1757 14 7 - 19 aompk--qvdrlbc------uj---- PurS [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component 1758 21 5 2 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain 1759 21 5 2 32 aompk-yqvdrlbcefghsnuj---- PurL [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain 1760 24 3 5 52 aompkzyqvdrlbcefghsnuj--tw PrsA [FE] COG0462 Phosphoribosylpyrophosphate synthetase 1761 12 8 - 19 -o-pkz-qv-r--c------u-xit- THY1 [F] COG1351 Predicted alternative thymidylate synthase 1764 16 9 8 31 a-mpkzyqv-rlbcef--s--j---- Pnp [F] COG0005 Purine nucleoside phosphorylase 1768 26 1 2 60 aompkzyqvdrlbcefghsnujxitw NrdA [F] COG0209 Ribonucleotide reductase alpha subunit 1769 20 3 3 41 -o----yq-drlbcefghsnujxitw NrdF [F] COG0208 Ribonucleotide reductase beta subunit 1772 26 1 2 48 aompkzyqvdrlbcefghsnujxitw Tmk [F] COG0125 Thymidylate kinase 1775 21 5 8 32 -om-kzyqvdrlbcefgh-nuj--tw Upp [F] COG0035 Uracil phosphoribosyltransferase 1776 13 6 9 26 -o----y-vd-lbce-gh-----itw Udk [F] COG0572 Uridine kinase 1778 25 2 - 42 aompkz-qvdrlbcefghsnujxitw PyrH [F] COG0528 Uridylate kinase 1780 24 3 2 38 aompkzyqvdrlbcefghsnuj-it- - [F] COG0127 Xanthosine triphosphate pyrophosphatase 1782 15 7 4 30 ------yq--rlb-ef-hsnujxit- Dut [F] COG0756 dUTPase 1786 15 10 6 42 a-mpk-yqv-rlb-efg--n----t- UbiB [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases 1788 21 6 - 37 aom--zyqvdrlbcefghsnuj-i-- RibB [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 1789 19 8 - 30 a-mpkzyq-d--bcefgh-nujxi-- UbiX [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase 1790 19 8 - 34 a-mpkzyq-d--bcefgh-nujxi-- UbiD [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases 1792 21 6 2 42 aompkzyq-d--bcefghsnujxi-- UbiA [H] COG0382 4-hydroxybenzoate polyprenyltransferase 1793 22 3 2 42 -o-p--yqvdrlbcefghsnujxitw FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase 1794 22 4 3 35 -om--zyq-drlbcefghsnujxitw - [H] COG0212 5-formyltetrahydrofolate cyclo-ligase 1796 17 5 - 33 ------yqvdrlbcefghsnuj-i-- FolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 1797 19 8 8 53 --mpk-yq-dr-bcefghsnujxi-- BioF [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes 1802 15 9 - 51 --m---yq-dr-b-efghsnuj-i-- BioA [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1806 16 8 - 34 --m---yqv-r-bcefghsnuj-i-- BioB [H] COG0502 Biotin synthase and related enzymes 1807 23 4 1 38 aom-k-yqvdrlbcefghsnujxit- BirA [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase 1819 21 6 1 32 aomp-zyq-dr-bcefghsnujxi-- HemB [H] COG0113 Delta-aminolevulinic acid dehydratase 1822 26 1 2 45 aompkzyqvdrlbcefghsnujxitw CoaE [H] COG0237 Dephospho-CoA kinase 1824 15 7 2 40 ------y-vdrlb-efghsn-j-i-w FolA [H] COG0262 Dihydrofolate reductase 1826 23 4 - 44 aompkzyqvdrlbcefghsnuj-i-- FolP [H] COG0294 Dihydropteroate synthase 1829 20 6 * 55 aompkzyq-dr-bcefghsnuj---- ThiF [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 1830 19 3 2 34 ------yqvdrlbcefghsnuj-itw RibF [H] COG0196 FAD synthase 1831 20 5 3 38 -o-p--yqvdrlbcefghsnujx-t- FolC [H] COG0285 Folylpolyglutamate synthase 1833 19 6 - 41 a--p--yqvdrlbcefghsnuj-i-- RibA [H] COG0807 GTP cyclohydrolase II 1837 25 2 7 78 aompkzyqvdrlbcefghsnujxit- IspA [H] COG0142 Geranylgeranyl pyrophosphate synthase 1838 19 8 1 35 aomp-z-q-dr-bcefghsnuj-i-- AlsD [H] COG0001 Glutamate-1-semialdehyde aminotransferase 1839 18 8 - 27 aomp-z-q-dr-bcefghsnu--i-- HemA [H] COG0373 Glutamyl-tRNA reductase 1842 22 5 - 39 aompkzyqvdrlb-efghsnuj--t- ThiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1844 17 8 - 30 -o--kzyqvdr-bcefg-snuj---- PanB [H] COG0413 Ketopantoate hydroxymethyltransferase 1846 17 8 2 27 -o---zyq-dr-bcefghsn-jxi-- LipA [H] COG0320 Lipoate synthase 1847 15 9 2 42 -o-pkzyqv--lbcefg------i-w LplA [H] COG0095 Lipoate-protein ligase A 1851 18 6 2 28 ---p--yqvdr-bcefghsnujxi-- UbiE [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis 1864 23 4 2 41 aompkzyqvdrlbcefg-snuj--tw NadE [H] COG0171 NAD synthase 1865 16 10 7 36 a---kzyqvdrlb-efgh--uj---- SIR2 [H] COG0846 NAD-dependent protein deacetylases, SIR2 family 1870 19 7 - 32 aom-k-yqv-rlbcefghsnuj---- NadC [H] COG0157 Nicotinate-nucleotide pyrophosphorylase 1871 16 6 2 32 ------yqv-rlbcefg-snuj--tw NadD [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase 1872 23 4 1 37 ao-pkzyqvdrlbcefghsnuj--tw PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase 1875 14 7 - 24 ------yqvdr-bcefg-snuj---- PanC [H] COG0414 Panthothenate synthetase 1877 23 4 2 45 aompkzyqvdrlbcefghsnuj--t- Dfp [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase 1882 21 6 1 33 aomp-zyq-dr-bcefghsnujxi-- HemC [H] COG0181 Porphobilinogen deaminase 1892 18 6 1 29 ---p--yq-drlbcefghsnujxi-- HemH [H] COG0276 Protoheme ferro-lyase (ferrochelatase) 1901 17 5 - 28 ------yqvdrlbcefghsnuj-i-- RibD [H] COG0117 Pyrimidine deaminase 1902 21 6 - 37 aom--zyqvdrlbcefghsnuj-i-- RibD [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis 1904 18 5 - 29 -o----yqvdrlbcefghsnuj-i-- RibC [H] COG0307 Riboflavin synthase alpha chain 1905 21 6 - 34 aom--zyqvdrlbcefghsnuj-i-- RibH [H] COG0054 Riboflavin synthase beta-chain 1906 14 6 4 21 aompkzyqv-r--c-f--s--j---- SAM1 [H] COG0499 S-adenosylhomocysteine hydrolase 1907 18 4 * 34 ------yqvdrlbcefghsnuj--tw MetK [H] COG0192 S-adenosylmethionine synthetase 1911 15 9 - 42 aomp-z-qvdr-bce-g---u--i-- ThiH [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes 1912 17 9 - 24 aom-k--qvdr-bcefg-snuj---- ThiC [H] COG0422 Thiamine biosynthesis protein ThiC 1919 17 7 1 27 ---p--yq-dr-bcefghsnujxi-- HemE [H] COG0407 Uroporphyrinogen-III decarboxylase 1921 19 8 1 36 aomp--yq-dr-bcefghsnu-xi-- HemD [H] COG1587 Uroporphyrinogen-III synthase 1922 18 4 8 41 ------yqvdrlbcefghsnujxi-- FabD [I] COG0331 (acyl-carrier-protein) S-malonyltransferase 1923 20 2 * 81 ------yqvdrlbcefghsnujxitw PlsC [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase 1928 17 9 3 41 --mp-zyq-drlbcefgh-nuj---- MmsB [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related proteins 1930 18 4 6 59 ------yqvdrlbcefghsnujxi-- FabB [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase 1935 20 6 * 120 aompkzy--drlbcefgh--ujx-t- PaaJ [I] COG0183 Acetyl-CoA acetyltransferases 1936 21 6 6 58 ao--k-yqvdrlbcefghsnujxi-- AccA [I] COG0825 Acetyl-CoA carboxylase alpha subunit 1939 20 2 5 59 ------yqvdrlbcefghsnujxitw AcpP [IQ] COG0236 Acyl carrier protein 1943 21 5 * 165 aomp-zy--drlbcefghsnujxi-- CaiC [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 1947 18 8 5 64 aomp-zyq-dr-bcefghs-uj---- Acs [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases 1948 22 5 8 60 ao--k-yqvdrlbcefghsnujxit- AccB [I] COG0511 Biotin carboxyl carrier protein 1949 21 6 * 70 aom---yq-drlbcefghsnujxit- AccC [I] COG0439 Biotin carboxylase 1951 26 1 2 48 aompkzyqvdrlbcefghsnujxitw CdsA [I] COG0575 CDP-diglyceride synthetase 1954 16 9 * 151 ao-p-zyq-drlb-efg-s--jx--- CaiD [I] COG1024 Enoyl-CoA hydratase/carnithine racemase 1966 19 7 5 74 -om-k-yq-drlbcefghs-ujx-t- PgpB [I] COG0671 Membrane-associated phospholipid phosphatase 1971 8 5 2 12 a-m-kzyqv-r--------------- INO1 [I] COG1260 Myo-inositol-1-phosphate synthase 1976 25 2 5 71 aompkzyqv-rlbcefghsnujxitw PgsA [I] COG0558 Phosphatidylglycerophosphate synthase 1977 17 9 2 31 aom---y--dr-b-efghsnujxi-- Psd [I] COG0688 Phosphatidylserine decarboxylase 1978 14 9 1 24 aom---y---r-b--f--snujxit- PssA [I] COG1183 Phosphatidylserine synthase 1979 18 7 7 62 a--p--y-v--lbcefghsnujxi-w Cls [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes 1981 16 6 - 33 ------yqvdrlb-e-g--nujxitw AcpS [I] COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) 1993 25 2 3 49 aompkzyqvdrlbcefghsnujxit- UppS [I] COG0020 Undecaprenyl pyrophosphate synthase 1996 24 3 * 228 aompkzy-vdrlbcefghsnujx-tw CcmA [Q] COG1131 ABC-type multidrug transport system, ATPase component 1997 21 4 * 204 -o--k-yqvdrlbcefghsnujxi-w MdlB [Q] COG1132 ABC-type multidrug/protein/lipid transport system, ATPase component 2001 19 8 4 70 ao-pkzyqv-rlb-efg-snuj--t- PncA [Q] COG1335 Amidases related to nicotinamidase 2009 23 4 * 481 ao-pkzyqvdrlbcefghsnujxi-- FabG [QR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 2022 23 4 - 83 aom-kzyqvdrlbcefghsnuj--tw NorM [Q] COG0534 Na+-driven multidrug efflux pump 2041 26 1 * 493 aompkzyqvdrlbcefghsnujxitw SmtA [QR] COG0500 SAM-dependent methyltransferases 2050 20 6 1 129 aompkzy-vdrlbcefghs-uj---- - [R] COG0842 ABC-type multidrug transport system, permease component 2053 23 4 3 121 aom--z-qvdrlbcefghsnujxitw PhnL [R] COG1136 ABC-type transport systems, involved in lipoprotein release, ATPase components 2063 23 3 * 65 aompkzyqvdrlbcefghsnuj---w RimI [R] COG0456 Acetyltransferases 2064 18 8 - 60 -om-k-y-vdrlbcefgh-nuj-i-- WbbJ [R] COG0110 Acetyltransferases (the isoleucine patch superfamily) 2078 25 2 * 212 aompkzyqvdrlbcefghsnujxit- - [R] COG0517 CBS domains 2080 19 7 - 45 a-mpkzyqvdrlbcef-h-n-jx--- - [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family 2085 13 8 - 30 a-----yqvdrlb--f--snuj---- - [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase 2087 26 1 3 81 aompkzyqvdrlbcefghsnujxitw ARC1 [R] COG0073 EMAP domain 2091 15 6 - 37 aom-kz-qvdrlbc--g-------tw - [R] COG0618 Exopolyphosphatase-related proteins 2095 19 7 - 28 -om-kz-qvdrlbcefghsn-j-i-- HflX [R] COG2262 GTPases 2101 16 11 8 50 ao--kzy-vdrlb-efg-s--j-i-- - [R] COG1073 Hydrolases of the alpha/beta superfamily 2103 17 8 - 28 aompkz--vdrlbce---s--j-it- - [R] COG0396 Iron-regulated ABC transporter ATPase subunit SufC 2114 18 6 2 39 aompkzy-vdrlbce--h---j-it- ElaC [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 2115 19 8 6 79 aompkzyqvdr-bcefg-s--j--t- - [R] COG0714 MoxR-like ATPases 2135 18 9 8 31 aompk-yq--r-b-e-ghsnuj-i-w - [R] COG1881 Phospholipid-binding protein 2155 13 9 - 18 -o-pkzyqvd-lb-e-----uj---- - [R] COG1832 Predicted CoA-binding protein 2168 19 3 1 33 ------yqvd-lbcefghsnujxitw ThdF [R] COG0486 Predicted GTPase 2169 20 2 3 35 ------yqvdrlbcefghsnujxitw Obg [R] COG0536 Predicted GTPase 2173 26 1 2 49 aompkzyqvdrlbcefghsnujxitw - [R] COG0012 Predicted GTPase 2179 19 5 - 33 aom-k-yqv--lb-efghsnujx--w - [R] COG0218 Predicted GTPases 2182 14 7 - 31 aompk--qvd-lb-e-----u---tw - [R] COG1418 Predicted HD superfamily hydrolase 2198 19 8 - 35 a--pk-yqvdrlb-efghsnuj-i-- - [R] COG1611 Predicted Rossmann fold nucleotide-binding protein 2199 20 2 2 34 ------yqvdrlbcefghsnujxitw - [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase 2205 22 5 7 64 aom---yqvdrlbcefghsnujxit- - [R] COG0042 Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family 2206 20 6 - 41 aompkzy-vdrlbcefghs-uj---- - [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold 2207 18 6 9 62 -----zyqvdrlbcefghs-ujx-t- PqqL [R] COG0612 Predicted Zn-dependent peptidases 2219 21 6 * 79 aompkzyqvdr-bcefg-snuj--t- - [R] COG0388 Predicted amidohydrolase 2232 17 9 2 29 a--pkzy-v-r-bcefg-snuj---w - [R] COG0579 Predicted dehydrogenase 2233 16 10 4 103 --mpk-yqvd-lbcefgh--uj---- MviM [R] COG0673 Predicted dehydrogenases and related proteins 2236 9 4 2 14 a-mpkzyqv------------j---- - [R] COG1355 Predicted dioxygenase 2243 16 5 2 27 ------yqvdrlbcefghsnuj---- - [R] COG0325 Predicted enzyme with a TIM-barrel fold 2248 16 6 5 41 ------yqv-rlbcefghsn-jx-t- RssA [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily 2273 19 8 6 85 -ompk-yqvdrlb-efghsn-j--t- - [R] COG1011 Predicted hydrolases of the HAD superfamily 2274 21 6 1 90 aompkzy-vdrlbce-gh-n-j-itw Cof [R] COG0561 Predicted hydrolases of the HAD superfamily 2275 22 4 * 276 ao-p-zyq-drlbcefghsnujx-tw MhpC [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 2278 24 3 7 48 aompkzyqv-rlbcefghsnujx-tw - [R] COG0061 Predicted kinase 2283 17 8 - 51 aompkz--vdrlbce---s--j-it- - [R] COG0719 Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufB 2304 17 8 - 48 -om-kz-qvdrlbcefg----j-it- - [R] COG1266 Predicted metal-dependent membrane protease 2342 21 6 1 71 aom-k--qvdrlbcefghsnujx-t- PerM [R] COG0628 Predicted permease 2348 21 5 2 93 aompkz-qvdrlbcefghsnuj---- - [R] COG0730 Predicted permeases 2354 16 8 6 55 ----k-y-vdrlbcefghsn-j-i-- - [R] COG0637 Predicted phosphatase/phosphohexomutase 2355 21 6 3 53 aom-k-yq-drlbcefghsnuj--tw Gph [R] COG0546 Predicted phosphatases 2369 18 9 - 43 -omp-z-q-dr-bcefghsnuj--t- FcbC [R] COG0824 Predicted thioesterase 2387 21 6 4 77 aompkzyq-dr-bcefghs-uj--tw ThiJ [R] COG0693 Putative intracellular protease/amidase 2396 19 6 - 30 aom--zyqvd---cefghsnuj-it- SurE [R] COG0496 Survival protein, predicted acid phosphatase 2398 23 4 * 321 aompk-yqvd-lbcefghsnujxit- NrfG [R] COG0457 TPR-repeat-containing proteins 2404 13 9 - 19 aom-k---vd-lbc-------jxit- BioY [R] COG1268 Uncharacterized ACR 2415 21 2 4 82 -o----yqvdrlbcefghsnujxitw - [R] COG1253 Uncharacterized CBS domain-containing proteins 2423 21 5 * 99 aompkzyqvdrlbcefgh---j--tw HcaD [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases 2433 22 5 * 44 aompkzyqvdrlbcefghs-uj--t- GlpG [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) 2440 17 5 - 30 -o----yqvdrlbcefg-snuj---w CinA [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) 2458 22 4 * 157 aompkzyqvdrlbcefghsnuj---- GloB [R] COG0491 Zn-dependent hydrolases, including glyoxylases 2459 16 8 - 27 aompkz-qvdr-bc--g--nuj---- SpoIVFB [R] COG1994 Zn-dependent proteases 2524 18 6 2 29 aompkzyqvdr--cefg-s-uj---- - [S] COG0062 Uncharacterized ACR 2566 18 7 - 28 aompk--qvdrlbc-f--sn-j--tw - [S] COG1354 Uncharacterized ACR 2587 13 7 1 23 ------y-vd-lb-efgh-nu---tw - [S] COG1739 Uncharacterized ACR 2595 18 7 1 38 aom-k-y--drlb-efgh-nu--itw - [S] COG0327 Uncharacterized ACR 2632 14 8 1 23 a-m-kzyqvdr-bcefg--------- - [S] COG0432 Uncharacterized ACR 2633 9 2 3 13 aompkzyqv----------------- - [S] COG2078 Uncharacterized ACR 2651 11 5 - 16 aompk-yqv-r-bc------------ - [S] COG0011 Uncharacterized ACR 2669 14 8 - 22 aom---yqvdrlbce-gh-------- - [S] COG0391 Uncharacterized ACR 2702 13 11 - 31 aom-k--q-d---c-fg--nuj--t- - [S] COG1432 Uncharacterized ACR 2727 20 2 1 37 ------yqvdrlbcefghsnujxitw - [S] COG0217 Uncharacterized ACR 2730 12 7 - 19 aom-k--q-d-lbc---------itw - [S] COG1624 Uncharacterized ACR 2737 13 10 2 23 a--pkzyqvdrl--ef-----j---- - [S] COG2110 Uncharacterized ACR related to the C-terminal domain of histone macroH2A1