browser position chr3:34544983-34545430
track name="m7:vad1:s71:78_" type=bedDetail description="#1 bls=581@[Amniot,Percom]" visibility=3 color=38,153,0 useScore=1 db=mm9 url=http://www.ihop-net.org/UniPub/iHOP/in?syns_1=$$&ncbi_tax_id_1=10090 htmlUrl=http://bio.math-inf.uni-greifswald.de/rexspecies2/getFile/cached/1/p/f/pub/docs/rsDesc.html
chr3 34545319 34545336 [@PolyA-441:15bp] 856 - PolyA About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545320 34545329 [@PU1_SPI1:434:*bp] 859 + PU1 | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
track name="m9:vad1:s71:78_" type=bedDetail description="#2 !bls=549@[Amniot]" visibility=3 color=0,38,153 useScore=1 db=mm9 url=http://www.ihop-net.org/UniPub/iHOP/in?syns_1=$$&ncbi_tax_id_1=10090 htmlUrl=http://bio.math-inf.uni-greifswald.de/rexspecies2/getFile/cached/1/p/f/pub/docs/rsDesc.html
chr3 34545074 34545086 [@GATAX+101:10bp] 891 + GATAX | Model made for | Homo sapiens, Xenopus laevis, Felis silvestris, Mus musculus, Gallus gallus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545041 34545053 [@GATAX-68:10bp] 852 - GATAX | Model made for | Homo sapiens, Xenopus laevis, Felis silvestris, Mus musculus, Gallus gallus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545044 34545055 [@GATA-70:*bp] 836 - GATA1 | Model made for | Homo sapiens, Xenopus laevis, Mus musculus, Gallus gallus |
About the matching model:
Gene 2623 at NCBI
iHOP says (Homo sapiens):
Mutations in GATA1 have been reported in acute megakaryoblastic leukaemia in Down's syndrome. We aimed to investigate changes in GATA1 in patients with Down's syndrome and either transient myeloid disorder (n=10) or acute megakaryoblastic leukaemia (n=6). Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 396450 at NCBI
iHOP says (-):
The enhancers contain binding sites for several ubiquitous and erythroid cell-specific nuclear proteins, including GATA-1, as demonstrated with GATA-1-specific antibodies. Given the T-rich composition of the GATA DNA binding site, it is possible that thymine's unique 5-methyl group may mediate some of these hydrophobic contacts to increase the stability of binding. We demonstrate that the cDNA encodes the specific Eryf1 binding activity found in erythrocytes. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 14460Gene 14460 at NCBI
iHOP says (Mus musculus):
We previously reported that STAT1 expression was significantly downregulated in Gata1-knockdown murine megakaryocytes, which also have impaired terminal maturation. Here, we show that GATA-2 is required for normal megakaryocyte development as well as aberrant megakaryopoiesis in Gata1 mutant cells. In contrast to GATA-1 deficiency, however, megakaryocytes fail to develop in the absence of FOG. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Erythroid transcription factor (GATA-binding factor 1) (GATA-1) (Eryf1) (GF-1) (NF-E1 DNA-binding protein); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells
Entry for target species Mus musculus: Gene 14460STRING says (Mus musculus):
GATA binding protein 1; Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells
chr3 34545072 34545083 [@GATA+99:*bp] 925 + GATA3 | Model made for | Gallus gallus |
About the matching model:
Gene 419106 at NCBI
iHOP says (Gallus gallus):
Two transactivation domains and two zinc finger regions are known to be important for the GATA3 function, whereas the role for other regions remains unclear. Thus, we identified a novel conserved YxKxHxxxRP motif adjacent to the C-terminal zinc finger domain of GATA3 that is indispensable for GATA3 DNA binding and functions. Comparative analysis of Gata3 and Gata2 expression during chicken inner ear development. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Gallus gallus):
GATA-binding factor 3 (GATA-3) (Transcription factor NF-E1C); Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes
Model's TFs' homologs in target species Mus musculus:
14462Gene 14462 at NCBI
iHOP says:
Pax 2/8- regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Introduction of an activated allele of Notch1 into CD4(+) T cells led to the specific and direct upregulation of a developmentally regulated Gata3 transcript that included the exon 1a sequences. We show that Gata3 is a direct target of c- Myb, and propose that c- Myb is an important regulator of Gata3, required for transduction of the T-cell receptor signal for subsequent helper cell lineage differentiation. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'
track name="m1:vad1:s71:78_" type=bedDetail description="#3 bls=360@[Tetrap]" visibility=3 color=158,204,142 useScore=1 db=mm9 url=http://www.ihop-net.org/UniPub/iHOP/in?syns_1=$$&ncbi_tax_id_1=10090 htmlUrl=http://bio.math-inf.uni-greifswald.de/rexspecies2/getFile/cached/1/p/f/pub/docs/rsDesc.html
chr3 34545220 34545227 [@Pdx1:300:5bp] 1000 - Pdx1 | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 18609Gene 18609 at NCBI
iHOP says (Mus musculus):
Together, these data suggest that insulin can act as a master regulator of islet survival by regulating Pdx1. Bridge-1, a Pdx1-binding partner and regulator of beta-cell survival, was increased significantly at low insulin doses. Repression of Pdx1 in adult mice impaired expression of insulin and glucagon, leading to diabetes within 14 days. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 18609STRING says (Mus musculus):
pancreatic and duodenal homeobox 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'- CC[CT]TAATGGG-3'
chr3 34545219 34545228 [@Nobox:300:7bp] 952 + Nobox | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 18291Gene 18291 at NCBI
iHOP says (Mus musculus):
These results suggest that NOBOX directly regulates the transcription of Pou5f1 and Gdf9 in oocytes during early folliculogenesis. In chromatin immunoprecipitation assays, DNA sequences from Pou5f1 and Gdf9 promoters co-precipitated with anti- NOBOX antibody. Nobox deficiency leads to rapid loss of postnatal oocytes. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 18291STRING says (Mus musculus):
NOBOX oogenesis homeobox; Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 aand GDF9 during early folliculogenesis
chr3 34545215 34545232 [@Prrx2_S8:301:*bp] 912 - S8 | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 20204Gene 20204 at NCBI
iHOP says (Mus musculus):
Correspondingly, the expression of Dlx5 and Dlx6, Distalless-related homeobox genes determining the ventral identity of the anterior branchial arches, and of the mandibular marker gene Pitx1 is significantly downregulated in the ET-1(-/-) mutant, whereas the expression of Dlx2 and the maxillary marker gene Prx2 is unaffected or rather upregulated. The aristaless-related homeobox genes Prx1 and Prx2 are required for correct skeletogenesis in many structures. Prx1 and Prx2 are closely related paired-class homeobox genes that are expressed in very similar patterns predominantly in mesenchyme. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 20204STRING says (Mus musculus):
paired related homeobox 2
chr3 34545216 34545231 [@CHX10:301:13bp] 965 + CHX10 | Model made for | Homo sapiens, Mus musculus, Gallus gallus |
About the matching model:
Gene 338917 at NCBI
iHOP says (Homo sapiens):
Human microphthalmia associated with mutations in the retinal homeobox gene CHX10. CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in Arab and Jewish kindreds. Mutations in the CHX10 gene in non-syndromic microphthalmia/ anophthalmia patients from Qatar. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 12677Gene 12677 at NCBI
iHOP says (Mus musculus):
Mutations in Chx10/ Vsx2 cause reduced retinal progenitor cell (RPC) proliferation and an absence of bipolar cells, while mutations in Vsx1 impair differentiation of cone bipolar cells. In the Chx10-null ocular retardation (or(J)) mouse, retinal progenitor cell (RPC) proliferation is impaired, and bipolar neurons, a late born cell type, fail to differentiate. Biochemical analysis also revealed binding of both Chx10 and Brn-2 to an enhancer of the CNS progenitor cell marker, Nestin. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Homeobox protein CHX10 (Ceh-10 homeodomain-containing homolog); Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity)
Entry for target species Mus musculus: Gene 12677STRING says (Mus musculus):
C. elegans ceh-10 homeo domain containing homolog; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells
chr3 34545218 34545231 [@CEBP+303:11bp] 847 + CEBP | Model made for | Homo sapiens, Mus musculus, Gallus gallus, Xenopus laevis, Rattus norvegicus |
About the matching model:
Entry for target species Mus musculus: Gene 12606Gene 12606 at NCBI
iHOP says (Mus musculus):
Previously, we demonstrated that granulocyte colony-stimulating factor ( G-CSF) receptor mRNA was undetectable and granulocyte maturation blocked in CCAAT enhancer binding protein alpha (C/EBPalpha)-deficient mice. RESULTS: In N-1 neurons, VPA induced significant increases in CEBPalpha and socs-3, but inhibited rstn and fiaf gene expression. When this phenotype was compared with that of mice carrying a targeted mutation of the Cebpa gene, the Cebpa-/- mice exhibited a similar developmental phenotype. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 12606STRING says (Mus musculus):
CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers
chr3 34545217 34545234 [@Brn2-304:15bp] 881 - Brn2 | Model made for | Homo sapiens, Rattus norvegicus |
About the matching model:
Gene 5454 at NCBI
iHOP says (Homo sapiens):
Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. We show here that in vivo Brn-2 is expressed in melanocytes but not in embryonic day 11.5 melanoblasts and that its expression is directly controlled by the Wnt/ beta-catenin signaling pathway in melanoma cell lines and in transgenic mice. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 29588 at NCBI
iHOP says (Rattus norvegicus):
We show that Tst-1/Oct6/SCIP, Brn-1, and Brn-2 were all down-regulated during the early phases of oligodendrocyte development both on RNA and protein level. Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. The deduced amino acid sequence of pCSC-1 displayed a striking degree of homology with the eel, rat brain-1, and rat brain-2 Na+ channel, thereby identifying pCSC-1 as a related member of the family of Na+ channel genes. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
POU domain, class 3, transcription factor 2 (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Protein Brn-2); Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)
STRING says (Rattus norvegicus):
POU domain, class 3, transcription factor 2 (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Protein Brn-2); Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters
Model's TFs' homologs in target species Mus musculus:
18992Gene 18992 at NCBI
iHOP says:
Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. We show here that in vivo Brn-2 is expressed in melanocytes but not in embryonic day 11.5 melanoblasts and that its expression is directly controlled by the Wnt/ beta-catenin signaling pathway in melanoma cell lines and in transgenic mice. Sox2 and SF1 may mediate basal nestin expression in undifferentiated P19EC cells, whereas Sox2, Brn1, and Brn2 bind to the enhancer in P19 neural progenitor cells. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
POU domain, class 3, transcription factor 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity)
chr3 34545222 34545233 [@SOX+313:*bp] 837 + SOX5 | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 20678Gene 20678 at NCBI
iHOP says (Mus musculus):
We show that Sox5 can suppress PDGFB-induced glioma development predominantly upon Ink4a-loss. Our data suggest a novel pathway, where Sox5 may suppress the oncogenic effects of PDGFB signaling during glioma development by regulating p27(Kip1) in a p19(Arf)-dependent manner, leading to acute cellular senescence. Loss of Sox5, however, partially rescued the strongly reduced melanoblast generation and marker gene expression in Sox10 heterozygous mice arguing that Sox5 functions in the melanocyte lineage by modulating Sox10 activity. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 20678STRING says (Mus musculus):
SRY-box containing gene 5; Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro
chr3 34545236 34545245 [@STAT5A:330:7bp] 955 + STAT5A | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Gene 6776 at NCBI
iHOP says (Homo sapiens):
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains. However, another mutant that lacked the carboxyl-terminal region retained STAT1alpha activation and nuclear translocation but was unable to fully activate STAT5 proteins, although it mediated their transient phosphorylation. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 20850Gene 20850 at NCBI
iHOP says (Mus musculus):
The few surviving Stat5a/b(null/null) mice lacked CD8(+) T lymphocytes. A massive reduction of CD8(+) T cells was also found in Stat5a/b(fl/fl) lck-cre transgenic animals. Importantly, the expression of suppressor of cytokine signaling (SOCS)3, a potent inhibitor of IL-12-induced Stat4 activation, was decreased in Stat5a(-/-) CD4(+) T cells. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription
Entry for target species Mus musculus: Gene 20850STRING says (Mus musculus):
signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription
chr3 34545236 34545245 [@STAT:334:7bp] 930 + STAT6 | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 20852Gene 20852 at NCBI
iHOP says (Mus musculus):
Furthermore, activated T cells from Stat6(-/)- mice produced more IFN-gamma in response to IL-18 than wild-type controls. Conversely, CD8+ T cells expressing a constitutively active mutant form Stat6 (Stat6VT) failed to express VLA-4 even in the absence of IL-4-stimulation. However, when both Stat4(-/-) and Stat6(-/-) CD4(+) T cells are coinjected into the same hosts, the Stat6(-/-) cells become dominant and out- compete Stat4(-/-) cells. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 6778 at NCBI
iHOP says (Homo sapiens):
Although we did not find any association between STAT6 activation and allergy, we do not exclude a possibility that stronger activation of this transcription factor is associated with an expression of allergic phenotype. The STAT6 G2964A gene polymorphism is not involved in the overall susceptibility or in determining the phenotype of IBD. Mounting evidence, in both patients and mouse models, supports a model where Stat6 is not a mere bystander, but rather, plays an active role in promoting a transformed phenotype. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 20852STRING says (Mus musculus):
signal transducer and activator of transcription 6; Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling
STRING says (Homo sapiens):
Signal transducer and activator of transcription 6 (IL-4 Stat); Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling
chr3 34545235 34545249 [@cEts1p-335:12bp] 859 - cEts1p54 | Model made for | Gallus gallus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545244 34545254 [@SRY+349:8bp] 871 + SRY | Model made for | Homo sapiens |
About the matching model:
Gene 6736 at NCBI
iHOP says (Homo sapiens):
The human Y-linked testis determining gene SRY encodes a protein with a DNA binding domain from the high mobility group box family. A new de novo mutation (A113T) in HMG box of the SRY gene leads to XY gonadal dysgenesis. In humans, mutations in the testis-determining gene SRY result in XY sex reversal with pure gonadal dysgenesis (PGD). Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Sex-determining region Y protein (Testis-determining factor); Transcriptional regulator which control a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Facilitates DNA bending. SRY H [...]
Model's TFs' homologs in target species Mus musculus:
chr3 34545294 34545303 [@STAT5A+402:7bp] 983 + STAT5A | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Gene 6776 at NCBI
iHOP says (Homo sapiens):
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains. However, another mutant that lacked the carboxyl-terminal region retained STAT1alpha activation and nuclear translocation but was unable to fully activate STAT5 proteins, although it mediated their transient phosphorylation. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 20850Gene 20850 at NCBI
iHOP says (Mus musculus):
The few surviving Stat5a/b(null/null) mice lacked CD8(+) T lymphocytes. A massive reduction of CD8(+) T cells was also found in Stat5a/b(fl/fl) lck-cre transgenic animals. Importantly, the expression of suppressor of cytokine signaling (SOCS)3, a potent inhibitor of IL-12-induced Stat4 activation, was decreased in Stat5a(-/-) CD4(+) T cells. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription
Entry for target species Mus musculus: Gene 20850STRING says (Mus musculus):
signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription
chr3 34545286 34545302 [@IRF+403:*bp] 840 + IRF | Model made for | Homo sapiens, Mus musculus, Gallus gallus, Xenopus laevis, Rattus norvegicus |
About the matching model:
Gene 84676 at NCBI
iHOP says (Homo sapiens):
The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy- associated MuRF1 gene. The aim of this work was to analyze the effect of adjuvant-induced arthritis on the muscle-specific ubiquitin ligases muscle ring finger 1 ( MuRF1) and muscle atrophy F-box (MAFbx) as well as on IGF-I and IGF- binding protein-5 ( IGFBP-5) gene expression in the skeletal muscle. Of the MURF family, only MURF-1 interacts with titin repeats A168/A169, whereas MURF-3 has been reported to affect microtubule stability. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein); E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric- associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells
Model's TFs' homologs in target species Mus musculus:
433766Gene 433766 at NCBI
iHOP says:
CONCLUSION: The results of this study demonstrate for the first time that TNF-alpha- induced reduction in skeletal muscle force development depends on the induction of the atrophy-related E3 ubiquitin ligase MuRF1. The GR antagonist RU38486 inhibited the dexamethasone- and corticosterone- induced increases in atrogin-1 and MuRF1 expression in L6 myotubes but not in C2C12 myotubes. Moreover, the mechanism for this inhibition involves Akt-mediated inhibition of the FoxO family of transcription factors; a mutant form of FOXO1, which prevents Akt phosphorylation, thereby prevents Akt- mediated inhibition of MuRF1 and MAFbx upregulation. Content provided by iHOP - Information Hyperlinked over Proteins...
chr3 34545291 34545300 [@GENINI+405:7bp] 945 + GENINI About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545294 34545303 [@STAT+408:7bp] 953 + STAT6 | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 20852Gene 20852 at NCBI
iHOP says (Mus musculus):
Furthermore, activated T cells from Stat6(-/)- mice produced more IFN-gamma in response to IL-18 than wild-type controls. Conversely, CD8+ T cells expressing a constitutively active mutant form Stat6 (Stat6VT) failed to express VLA-4 even in the absence of IL-4-stimulation. However, when both Stat4(-/-) and Stat6(-/-) CD4(+) T cells are coinjected into the same hosts, the Stat6(-/-) cells become dominant and out- compete Stat4(-/-) cells. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 6778 at NCBI
iHOP says (Homo sapiens):
Although we did not find any association between STAT6 activation and allergy, we do not exclude a possibility that stronger activation of this transcription factor is associated with an expression of allergic phenotype. The STAT6 G2964A gene polymorphism is not involved in the overall susceptibility or in determining the phenotype of IBD. Mounting evidence, in both patients and mouse models, supports a model where Stat6 is not a mere bystander, but rather, plays an active role in promoting a transformed phenotype. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 20852STRING says (Mus musculus):
signal transducer and activator of transcription 6; Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling
STRING says (Homo sapiens):
Signal transducer and activator of transcription 6 (IL-4 Stat); Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling
chr3 34545295 34545303 [@NFATC2+409:6bp] 892 + NFATC2 | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 18019Gene 18019 at NCBI
iHOP says (Mus musculus):
Ca2+/calcineurin signaling induces a limited set of anergy-associated genes, distinct from genes induced in the productive immune response; these genes are upregulated in vivo in tolerant T cells and are largely NFAT dependent. The molecular cloning of NFATp should allow detailed analysis of a T cell transcription factor that is central to initiation of the immune response. Whereas stimulated T cells from wild-type mice show a transient increase and then a rapid decline in the steady-state levels of IL-4 mRNA in vitro, the levels of IL-4 gene transcripts in NFAT1-deficient T cells are maintained at high levels under the same conditions. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 18019
chr3 34545292 34545306 [@OCTx+409:12bp] 849 + OCTx | Model made for | Homo sapiens, Xenopus laevis, Hylobates lar, Cercopithecus aethiops, Felis silvestris, Mus musculus, Gallus gallus, Rattus rattus, Rattus norvegicus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545318 34545329 [@MZF+436:*bp] 895 + MZF1513 | Model made for | Homo sapiens |
About the matching model:
Gene 7593 at NCBI
iHOP says (Homo sapiens):
FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1. Overexpression of FHL3 in KU812 cells suppressed the beta-chain promoter activity through the element in the fourth intron in an MZF-1-dependent manner. These results indicate that Sp1/Sp3 and MZF1 are important transcription factors regulating N-cadherin promoter activity and expression in osteoblasts. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Myeloid zinc finger 1 (MZF-1) (Zinc finger protein 42) (Zinc finger and SCAN domain-containing protein 6); May be one regulator of transcriptional events during hemopoietic development
Model's TFs' homologs in target species Mus musculus:
109889Gene 109889 at NCBI
iHOP says:
Finally, we analyzed promoters of regulated genes which where apparently not regulated by c-Myc or other c-Myc targeted TFs and identified overrepresented Oct1, Mzf1, Ppargamma, Plzf, Ets, and HmgIY binding sites when compared against control promoter background. Myeloid-specific transcriptional activation by murine myeloid zinc-finger protein 2. Furthermore, in an in vivo competition assay, the middle region of MZF-2 inhibited the mMZF-2-mediated transcription activation. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
myeloid zinc finger 1
chr3 34545301 34545313 [@ELF5:413:*bp] 863 + ELF5 | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 13711Gene 13711 at NCBI
iHOP says (Mus musculus):
To test the hypothesis that ELF5 represses distal epithelial differentiation, we generated a transgenic mouse model in which a doxycycline inducible HA-tagged mouse Elf5 transgene was placed under the control of the lung epithelium-specific human SFTPC promoter. The loss of one functional allele led to complete developmental arrest of the mammary gland in pregnant Elf5 heterozygous mice. Our data demonstrate that Elf5 is essential for developmental processes in the embryo and in the mammary gland during pregnancy. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 13711STRING says (Mus musculus):
E74-like factor 5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter
chr3 34545109 34545122 [@TFIIA-139:11bp] 850 - TFIIA | Model made for | Homo sapiens |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
track name="m4:vad1:s71:78_" type=bedDetail description="#4 !bls=275@[Boreot,Amniot]" visibility=3 color=188,142,204 useScore=1 db=mm9 url=http://www.ihop-net.org/UniPub/iHOP/in?syns_1=$$&ncbi_tax_id_1=10090 htmlUrl=http://bio.math-inf.uni-greifswald.de/rexspecies2/getFile/cached/1/p/f/pub/docs/rsDesc.html
chr3 34545189 34545197 [@MOVOB-260:6bp] 896 - MOVOB | Model made for | Mus musculus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545156 34545165 [@STAT-224:7bp] 891 - STAT1 | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 20846Gene 20846 at NCBI
iHOP says (Mus musculus):
IL-27 signaling through TCCR/ WSX-1 induces phosphorylation of Stat1, Stat3, Stat4, and Stat5. Stat1 was phosphorylated by IFN-alpha in Tyk2-deficient cells, although the level of phosphorylation was weaker than that observed in wild type mice. Such effects are associated with impaired IFN-dependent phosphorylation of Stat1 on Tyr(701) and Stat3 on Tyr(705) and defective binding of Stat complexes to ISRE or GAS elements. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 6772 at NCBI
iHOP says (Homo sapiens):
Interestingly, no cytoplasmic tyrosines are required for phosphorylation of STAT1. HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines. Phosphorylation at Ser727 in signal transducer and activator of transcription 1 ( STAT1) is essential for its activation and signal transduction. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 20846STRING says (Mus musculus):
signal transducer and activator of transcription 1; Transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element. This multiprotein transcription factor is termed ISGF3
STRING says (Homo sapiens):
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84); Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to ac [...]
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chr3 34545157 34545164 [@TEF1+224:5bp] 1000 + TEF1 | Model made for | Homo sapiens, Mus musculus, Rattus norvegicus |
About the matching model:
Entry for target species Mus musculus: Gene 21676Gene 21676 at NCBI
iHOP says (Mus musculus):
However, the mechanism whereby Vgl-2 regulates TEF-1 factors and the requirement for Vgl-2 for muscle-specific gene expression were not known. Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals. Our data therefore show that p38 MAPKs regulate TEF-1 and C/EBPbeta transcriptional activity in the absence of environmental stress and suggests a role for p38alpha in the expression of extracellular matrix components that maintain organ architecture. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 21676STRING says (Mus musculus):
TEA domain family member 1; Binds specifically and cooperatively to the SPH and GT- IIC "enhansons" (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif
chr3 34545189 34545197 [@MOVOB-260:6bp] 896 - MOVOB | Model made for | Mus musculus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545189 34545199 [@ACAAT-265:8bp] 836 - ACAAT About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545156 34545165 [@STAT-224:7bp] 891 - STAT1 | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 20846Gene 20846 at NCBI
iHOP says (Mus musculus):
IL-27 signaling through TCCR/ WSX-1 induces phosphorylation of Stat1, Stat3, Stat4, and Stat5. Stat1 was phosphorylated by IFN-alpha in Tyk2-deficient cells, although the level of phosphorylation was weaker than that observed in wild type mice. Such effects are associated with impaired IFN-dependent phosphorylation of Stat1 on Tyr(701) and Stat3 on Tyr(705) and defective binding of Stat complexes to ISRE or GAS elements. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 6772 at NCBI
iHOP says (Homo sapiens):
Interestingly, no cytoplasmic tyrosines are required for phosphorylation of STAT1. HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines. Phosphorylation at Ser727 in signal transducer and activator of transcription 1 ( STAT1) is essential for its activation and signal transduction. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 20846STRING says (Mus musculus):
signal transducer and activator of transcription 1; Transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element. This multiprotein transcription factor is termed ISGF3
STRING says (Homo sapiens):
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84); Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to ac [...]
track name="m6:vad1:s71:78_" type=bedDetail description="#7 bls=59@[Euther]" visibility=3 color=153,114,0 useScore=1 db=mm9 url=http://www.ihop-net.org/UniPub/iHOP/in?syns_1=$$&ncbi_tax_id_1=10090 htmlUrl=http://bio.math-inf.uni-greifswald.de/rexspecies2/getFile/cached/1/p/f/pub/docs/rsDesc.html
chr3 34545165 34545182 [@CBFcor+226:15bp] 848 + CBFcorebindingfactor About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545167 34545179 [@NFY:237:10bp] 870 - NFY | Model made for | Homo sapiens, Mus musculus, long, Rattus norvegicus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545170 34545179 [@corebi+239:7bp] 869 + corebindingfactor | Model made for | Felis silvestris |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545315 34545326 [@SP1-434:9bp] 847 - SP1 | Model made for | Homo sapiens |
About the matching model:
Gene 6667 at NCBI
iHOP says (Homo sapiens):
Promoter analysis of intestinal genes induced during iron-deprivation reveals enrichment of conserved SP1-like binding sites. Furthermore, analysis of promoter sequences identified many genes with multiple, conserved SP1 and FOX binding sites, the relative location of which within orthologous promoters was highly conserved. Activation requires the binding sites for the ubiquitous transcription factor Sp1 on the proximal promoter. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Transcription factor Sp1; Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter
Model's TFs' homologs in target species Mus musculus:
20683Gene 20683 at NCBI
iHOP says:
We can show that both the Sp1 and the E-box binding sites are necessary for proper regulation of bax transcription and show by genomic DMS footprinting that all these sites are occupied in vivo. Region II is the single most important Sp1/3 binding site in transcriptional activation, and multiple combined mutations in the GC-boxes abolished the hamTERT promoter activity. Mutational analysis revealed that a cluster of predicted binding sites for Sp1, AP-1/CREB/ATF and E box-binding transcription factors is essential for full activity of the p39 promoter. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
trans-acting transcription factor 1; Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites
chr3 34545069 34545076 [@Church+92:5bp] 975 + Churchill | Model made for | Gallus gallus |
About the matching model:
Gene 395448 at NCBI
iHOP says (-):
Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling. These findings reveal a dynamic role for chch in regulating cell movement and fate during early development. The zinc-finger transcription factor, Churchill (ChCh) has been proposed to regulate cell fate by regulating cell movements during gastrulation in the chick. Content provided by iHOP - Information Hyperlinked over Proteins...
Model's TFs' homologs in target species Mus musculus:
chr3 34545067 34545076 [@MZF1+92:7bp] 835 + MZF1 | Model made for | Homo sapiens |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545069 34545076 [@MZF114+93:5bp] 970 + MZF114 | Model made for | Homo sapiens |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545064 34545073 [@E2F:89:*bp] 841 + E2F | Model made for | Homo sapiens |
About the matching model:
Gene 1869 at NCBI
iHOP says (Homo sapiens):
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. These results suggest a new mechanism for controlling the cell-cycle regulatory activity of E2F1. Differential cell cycle effects induced by E2F1 mutants. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1); Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate b [...]
Model's TFs' homologs in target species Mus musculus:
13555Gene 13555 at NCBI
iHOP says:
Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. By targeting the entire subclass of E2F transcriptional activators we provide direct genetic evidence for their essential role in cell cycle progression, proliferation and development. These observations indicate that E2F transcription factors are regulated by a succession of partner proteins with which they associate during defined stages of the cell cycle. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
track name="m3:vad1:s71:78_" type=bedDetail description="#10 !bls=20@[Murina]" visibility=3 color=142,158,204 useScore=1 db=mm9 url=http://www.ihop-net.org/UniPub/iHOP/in?syns_1=$$&ncbi_tax_id_1=10090 htmlUrl=http://bio.math-inf.uni-greifswald.de/rexspecies2/getFile/cached/1/p/f/pub/docs/rsDesc.html
chr3 34545121 34545135 [@Oct1:183:12bp] 901 - Oct1 | Model made for | Homo sapiens, Chinese hamster , Xenopus laevis, Hylobates lar, Cercopithecus aethiops, Mus musculus, Gallus gallus, Rattus norvegicus |
About the matching model:
Gene 399316 at NCBI
Gene 396463 at NCBI
iHOP says (Gallus gallus):
The previously described POU domain (termed POU for its presence in the Pit-1, Oct-1/Oct-2, and Unc-86 genes) and homeobox domain are 100% conserved between the two protein products. Two major DNA-binding proteins that bind in a sequence-specific manner to the octamer DNA sequence have been identified in mammalian species--a ubiquitously expressed protein ( Oct-1) and a lymphoid-specific protein (Oct-2). The predicted protein sequence of the chicken Oct-1 gene demonstrated that the gene for Oct-1 has been highly conserved during vertebrate evolution with an overall 96% amino acid sequence identity between the chicken and human proteins. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Gallus gallus):
POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1); Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity)
Model's TFs' homologs in target species Mus musculus:
18986Gene 18986 at NCBI
iHOP says:
Finally, the cytokine interleukin-6 induces Oct-1 gene expression, providing a biologically relevant means by which NF-kappaB-dependent gene expression can be selectively reverted by Oct-1 to quiescent levels. Thus, Oct-1 binds to the GnRH enhancer in vitro, and this binding is critical to the transcriptional activity of this neuron-specific enhancer in GT1 cells. Finally, Pbx1 is expressed in GnRH neurons in embryonic as well as mature mice, suggesting that the associations between TALE homeodomain proteins and Oct-1 regulate neuron-specific expression of the GnRH gene in vivo. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity)
chr3 34545241 34545252 [@GATA1+344:9bp] 836 + GATA1 | Model made for | Homo sapiens, Xenopus laevis, Mus musculus, Gallus gallus |
About the matching model:
Gene 2623 at NCBI
iHOP says (Homo sapiens):
Mutations in GATA1 have been reported in acute megakaryoblastic leukaemia in Down's syndrome. We aimed to investigate changes in GATA1 in patients with Down's syndrome and either transient myeloid disorder (n=10) or acute megakaryoblastic leukaemia (n=6). Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 396450 at NCBI
iHOP says (-):
The enhancers contain binding sites for several ubiquitous and erythroid cell-specific nuclear proteins, including GATA-1, as demonstrated with GATA-1-specific antibodies. Given the T-rich composition of the GATA DNA binding site, it is possible that thymine's unique 5-methyl group may mediate some of these hydrophobic contacts to increase the stability of binding. We demonstrate that the cDNA encodes the specific Eryf1 binding activity found in erythrocytes. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 14460Gene 14460 at NCBI
iHOP says (Mus musculus):
We previously reported that STAT1 expression was significantly downregulated in Gata1-knockdown murine megakaryocytes, which also have impaired terminal maturation. Here, we show that GATA-2 is required for normal megakaryocyte development as well as aberrant megakaryopoiesis in Gata1 mutant cells. In contrast to GATA-1 deficiency, however, megakaryocytes fail to develop in the absence of FOG. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Erythroid transcription factor (GATA-binding factor 1) (GATA-1) (Eryf1) (GF-1) (NF-E1 DNA-binding protein); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells
Entry for target species Mus musculus: Gene 14460STRING says (Mus musculus):
GATA binding protein 1; Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells
chr3 34545251 34545258 [@HNF4+359:5bp] 990 + HNF4 | Model made for | Homo sapiens, Mus musculus, Xenopus laevis, Tamias asiaticus, Rattus norvegicus |
About the matching model:
Gene 25735 at NCBI
iHOP says (Rattus norvegicus):
Our data strongly suggest that the coactivator PGC-1 is involved in the regulation of this gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein ( CREB). CONCLUSIONS/INTERPRETATION: Prenatal dexamethasone exposure caused a permanent increase in hepatic Hnf4a mRNA. RESULTS: Prenatal dexamethasone exposure significantly elevated Hnf4a mRNA expression in foetal and adult liver. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 379762 at NCBI
Gene 3172 at NCBI
iHOP says (Homo sapiens):
Common and rare variants of the hepatocyte nuclear factor 4alpha ( HNF4A) gene have been associated with type 2 diabetes and related traits in several populations suggesting the involvement of this transcription factor in diabetes pathogenesis. Maturity-onset diabetes of the young caused by a balanced translocation where the 20q12 break point results in disruption upstream of the coding region of hepatocyte nuclear factor-4alpha ( HNF4A) gene. Macrosomia and neonatal hypoglycaemia in RW pedigree subjects with a mutation (Q268X) in the gene encoding hepatocyte nuclear factor 4alpha ( HNF4A). Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Rattus norvegicus):
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14); Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine
STRING says (Homo sapiens):
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14); Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine
Model's TFs' homologs in target species Mus musculus:
15378Gene 15378 at NCBI
iHOP says:
Promoter mutation analysis demonstrated that SHP repressed human ANG promoter activity through the element, which has been previously determined as a binding site for hepatocyte nuclear factor-4 ( HNF-4). The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells. In stage one, maximal induction requires a GR-dependent increase in PXR and RXRalpha expression, and stage two is characterized by direct transcriptional activation of CYP3A23, which is dependent on ligand-activated PXR as well as accessory factors bound at the DexRE-1 and HNF-4 sites. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
hepatic nuclear factor 4, alpha; Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine
chr3 34545275 34545285 [@WT1+388:8bp] 852 + WT1 | Model made for | Homo sapiens, Rattus norvegicus, Mus musculus |
About the matching model:
Gene 7490 at NCBI
iHOP says (Homo sapiens):
Frequency and heritability of WT1 mutations in nonsyndromic Wilms' tumor patients: a UK Children's Cancer Study Group Study. The disease is caused by mutations that affect the zinc finger structure of the Wilms' tumor protein ( WT1), but the mechanisms whereby these mutations result in glomerulosclerosis remain largely obscure. A stable cell line was established from MCF10AT3B cells that ectopically expressed the Wilms' tumor suppressor, WT1. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 22431Gene 22431 at NCBI
iHOP says (Mus musculus):
Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1. The Wilms' tumor suppressor Wt1 activates transcription of the erythropoietin receptor in hematopoietic progenitor cells. Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 24883 at NCBI
iHOP says (Rattus norvegicus):
We investigated whether two WT1 splice variants lacking or including a three-amino-acid (KTS) insertion between the third and fourth zinc finger in the DNA- binding domain could repress the IR promoter in vitro. Finally, ectopic expression of WT1 attenuated apoptosis, and coexpression of Par-4 but not a leucine zipperless mutant of Par-4 rescued the cells from the antiapoptotic effect of WT1. Deletional mapping indicated that distinct regions of the IR promoter mediated the effects of the two isoforms and DNaseI footprint analysis identified potential WT1 binding sites within these regions. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Wilms' tumor protein (WT33); Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'
Entry for target species Mus musculus: Gene 22431STRING says (Mus musculus):
Wilms tumor homolog; Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'
STRING says (Rattus norvegicus):
Wilms' tumor protein homolog; Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'
chr3 34545276 34545285 [@MZF1-389:7bp] 852 - MZF1 | Model made for | Homo sapiens |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545293 34545305 [@Oct1:409:*bp] 929 + Oct1 | Model made for | Homo sapiens, Cercopithecus aethiops, Mus musculus, Gallus gallus, Xenopus laevis, Hylobates lar, Rattus norvegicus |
About the matching model:
Gene 399316 at NCBI
Gene 396463 at NCBI
iHOP says (Gallus gallus):
The previously described POU domain (termed POU for its presence in the Pit-1, Oct-1/Oct-2, and Unc-86 genes) and homeobox domain are 100% conserved between the two protein products. Two major DNA-binding proteins that bind in a sequence-specific manner to the octamer DNA sequence have been identified in mammalian species--a ubiquitously expressed protein ( Oct-1) and a lymphoid-specific protein (Oct-2). The predicted protein sequence of the chicken Oct-1 gene demonstrated that the gene for Oct-1 has been highly conserved during vertebrate evolution with an overall 96% amino acid sequence identity between the chicken and human proteins. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Gallus gallus):
POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1); Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity)
Model's TFs' homologs in target species Mus musculus:
18986Gene 18986 at NCBI
iHOP says:
Finally, the cytokine interleukin-6 induces Oct-1 gene expression, providing a biologically relevant means by which NF-kappaB-dependent gene expression can be selectively reverted by Oct-1 to quiescent levels. Thus, Oct-1 binds to the GnRH enhancer in vitro, and this binding is critical to the transcriptional activity of this neuron-specific enhancer in GT1 cells. Finally, Pbx1 is expressed in GnRH neurons in embryonic as well as mature mice, suggesting that the associations between TALE homeodomain proteins and Oct-1 regulate neuron-specific expression of the GnRH gene in vivo. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity)
chr3 34545299 34545310 [@Hltf_RUSH1a-414:9bp] 942 - Hltf | Model made for | Oryctolagus cuniculus |
About the matching model:
Gene 100009232 at NCBI
iHOP says (-):
Rabbit RUSH/ SMARCA3 mRNA is primarily regulated at the proximal promoter (-162/+90) via a PRE ( progesterone-response element) half-site/overlapping Y-box domain (-38/-26) and two Sp (specificity protein) 3 sites centred at -128 and -58. Moreover, progesterone-dependent DNA looping is an adjunct to progesterone induction of the RUSH/ SMARCA3 gene because the availability of RUSH isoforms and relevant binding partners is progesterone-regulated. Progesterone regulation of RUSH/ SMARCA3/ HLTF includes DNA looping. Content provided by iHOP - Information Hyperlinked over Proteins...
Model's TFs' homologs in target species Mus musculus:
chr3 34545303 34545318 [@GATA+420:*bp] 916 + GATA1 | Model made for | Homo sapiens, Xenopus laevis, Mus musculus, Gallus gallus |
About the matching model:
Gene 2623 at NCBI
iHOP says (Homo sapiens):
Mutations in GATA1 have been reported in acute megakaryoblastic leukaemia in Down's syndrome. We aimed to investigate changes in GATA1 in patients with Down's syndrome and either transient myeloid disorder (n=10) or acute megakaryoblastic leukaemia (n=6). Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 396450 at NCBI
iHOP says (-):
The enhancers contain binding sites for several ubiquitous and erythroid cell-specific nuclear proteins, including GATA-1, as demonstrated with GATA-1-specific antibodies. Given the T-rich composition of the GATA DNA binding site, it is possible that thymine's unique 5-methyl group may mediate some of these hydrophobic contacts to increase the stability of binding. We demonstrate that the cDNA encodes the specific Eryf1 binding activity found in erythrocytes. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 14460Gene 14460 at NCBI
iHOP says (Mus musculus):
We previously reported that STAT1 expression was significantly downregulated in Gata1-knockdown murine megakaryocytes, which also have impaired terminal maturation. Here, we show that GATA-2 is required for normal megakaryocyte development as well as aberrant megakaryopoiesis in Gata1 mutant cells. In contrast to GATA-1 deficiency, however, megakaryocytes fail to develop in the absence of FOG. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Erythroid transcription factor (GATA-binding factor 1) (GATA-1) (Eryf1) (GF-1) (NF-E1 DNA-binding protein); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells
Entry for target species Mus musculus: Gene 14460STRING says (Mus musculus):
GATA binding protein 1; Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells
chr3 34545306 34545316 [@GATA3+421:*bp] 891 + GATA3 | Model made for | Homo sapiens |
About the matching model:
Gene 2625 at NCBI
iHOP says (Homo sapiens):
Notch signaling is necessary for GATA3 function in the initiation of T cell development. The transcription factor GATA3 is essential at multiple stages of T cell development, including the earliest double-negative stages, beta-selection and CD4 single-positive thymocytes. GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3); Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'
Model's TFs' homologs in target species Mus musculus:
14462Gene 14462 at NCBI
iHOP says:
Pax 2/8- regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Introduction of an activated allele of Notch1 into CD4(+) T cells led to the specific and direct upregulation of a developmentally regulated Gata3 transcript that included the exon 1a sequences. We show that Gata3 is a direct target of c- Myb, and propose that c- Myb is an important regulator of Gata3, required for transduction of the T-cell receptor signal for subsequent helper cell lineage differentiation. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'
chr3 34545303 34545313 [@T3R-422:8bp] 846 - T3R | Model made for | Homo sapiens, Mus musculus, Rattus norvegicus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545321 34545333 [@NFk:438:*bp] 861 - NFKB1 | Model made for | Homo sapiens |
About the matching model:
Gene 4790 at NCBI
iHOP says (Homo sapiens):
These findings have broadened the role of NF-kappa B from that of a regulator of immune and inflammatory responses to include an involvement in the regulation of apoptosis. NF-kappaB activation conferred resistance to TNF-alpha-induced apoptosis in HCV core-transfected cells. Taken together, our data demonstrate that cFLIP(L) is not only a central antiapoptotic modulator of TRAIL-mediated apoptosis but also an inhibitor of TRAIL-induced NF-kappaB activation and subsequent proinflammatory target gene expression. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit]; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bin [...]
Model's TFs' homologs in target species Mus musculus:
18033Gene 18033 at NCBI
iHOP says:
One of the key proteins that modulates the apoptotic response is NF-kappaB, a transcription factor that can protect or contribute to apoptosis. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. These findings suggest that by inhibiting the antiapoptotic action of NF-kappaB and inducing the proapoptotic activity of JNK, OHPK1 supports apoptosis in T cells. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and [...]
chr3 34545322 34545331 [@STAT-443:7bp] 980 - STAT3 | Model made for | Homo sapiens, Mus musculus |
About the matching model:
Gene 6774 at NCBI
iHOP says (Homo sapiens):
Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Stimulation of human and mouse ES cells with gp130 cytokines resulted in a robust phosphorylation of downstream ERK1, ERK2, and Akt kinases, as well as the STAT3 transcription factor. We further observed that hypoxic exposure significantly increased the phosphorylation of STAT3 (pSTAT3) at the Tyr705 residue in A2780 cell line. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 20848Gene 20848 at NCBI
iHOP says (Mus musculus):
Despite intact expression and phosphorylation of Stat3alpha, overall Stat3 activity was impaired in Stat3beta(-/-) cells. These factors act via receptor complexes involving gp130 and LIFR-beta and ligand binding leads to activation of various signaling pathways, including phosphorylation of Stat3. The ability of GH to activate both Stat1 and Stat3 (i.e. increase their tyrosyl phosphorylation and ability to bind to DNA) suggests that gene regulation by GH involves multiple Stat proteins. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Signal transducer and activator of transcription 3 (Acute-phase response factor); Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA
Entry for target species Mus musculus: Gene 20848STRING says (Mus musculus):
signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way
chr3 34545322 34545332 [@LRF:443:8bp] 844 + LRF | Model made for | Homo sapiens, Rattus norvegicus, Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 16969Gene 16969 at NCBI
iHOP says (Mus musculus):
Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis. Thus, FBI-1, a POZ zinc finger transcription factor, is induced during the early phases of human and murine preadipocyte differentiation where it may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation. Murine cell lines constitutively expressing FBI-1 showed evidence for accelerated adipogenesis with earlier induction of markers of differentiation and enhanced lipid accumulation, suggesting that FBI-1 may be an active participant in the differentiation process. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 117107 at NCBI
iHOP says (Rattus norvegicus):
In addition, OCZF specifically bound to the guanine-rich consensus sequences of Egr-1 and c-Krox. Transient transfection assays indicate that OCZF can repress transcription activity like other POZ domain proteins. Furthermore, antisense but not sense phosphorothioate oligodeoxynucleotides (ODNs) for OCZF cDNA suppressed the formation of osteoclast-like multinucleated cells (MNCs) in bone marrow culture, whereas the same ODNs did not significantly affect the formation of macrophage polykaryons and mononuclear preosteoclast-like cells (POCs). Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 16969STRING says (Mus musculus):
zinc finger and BTB domain containing 7a; Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'
STRING says (Rattus norvegicus):
Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Osteoclast-derived zinc finger protein); Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity)
chr3 34545327 34545335 [@MOVOB-448:6bp] 892 - MOVOB | Model made for | Mus musculus |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545327 34545337 [@Nkx32-449:*bp] 926 - Nkx32 | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 12020Gene 12020 at NCBI
iHOP says (Mus musculus):
By using a retroviral system to overexpress Pax1 in chick presomitic mesoderm explants, we show that Pax1 can substitute for Shh in inducing Bapx1 expression and in initiating chondrogenic differentiation. In the present study, the transcriptional repressor vertebrate homolog of Drosophila bagpipe ( Bapx1) was found to be a direct target of Sox9 for repression of Runx2 expression in chondrocytes. By focusing on vertebral column formation, we found that expressions of Pax1, Nkx3.1, and Bapx1 are regulated by Paraxis and that Pax9 expression was severely affected in the Mesp2/ Paraxis double-null embryo. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 12020STRING says (Mus musculus):
bagpipe homeobox gene 1 homolog (Drosophila)
chr3 34545340 34545350 [@TFIII+463:8bp] 861 + TFIII | Model made for | Homo sapiens |
About the matching model:
Gene 2969 at NCBI
iHOP says (Homo sapiens):
We and others have shown that TFII-I can interact physically and functionally with Bruton's tyrosine kinase ( Btk), a hematopoietic non-receptor protein tyrosine kinase that is critical for B lymphocyte development. Ectopic expression of wild-type Btk enhances TFII-I-mediated transcriptional activation and its tyrosine phosphorylation in transient-transfection assays. Our studies provide a molecular link that connects the c-Src tyrosine kinase transduction pathway to ER stress-induced transcriptional activation of Grp78 mediated by TFII-I. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein); Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene [...]
Model's TFs' homologs in target species Mus musculus:
14886Gene 14886 at NCBI
iHOP says:
These data suggest that Bright functions as a three-component protein complex in the immunoglobulin locus and tie together previous data indicating important roles for Btk and TFII-I in B lymphocytes. Our studies provide a molecular link that connects the c-Src tyrosine kinase transduction pathway to ER stress-induced transcriptional activation of Grp78 mediated by TFII-I. In this work, we show that TFII-I directly interacts with human Bright through amino acids in Bright's protein interaction domain and that specific tyrosine residues of TFII-I are essential for Bright-induced activity of an immunoglobulin reporter gene. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
general transcription factor II I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similari [...]
chr3 34545344 34545354 [@WT1-468:8bp] 918 - WT1 | Model made for | Homo sapiens, Rattus norvegicus, Mus musculus |
About the matching model:
Gene 7490 at NCBI
iHOP says (Homo sapiens):
Frequency and heritability of WT1 mutations in nonsyndromic Wilms' tumor patients: a UK Children's Cancer Study Group Study. The disease is caused by mutations that affect the zinc finger structure of the Wilms' tumor protein ( WT1), but the mechanisms whereby these mutations result in glomerulosclerosis remain largely obscure. A stable cell line was established from MCF10AT3B cells that ectopically expressed the Wilms' tumor suppressor, WT1. Content provided by iHOP - Information Hyperlinked over Proteins...Entry for target species Mus musculus: Gene 22431Gene 22431 at NCBI
iHOP says (Mus musculus):
Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1. The Wilms' tumor suppressor Wt1 activates transcription of the erythropoietin receptor in hematopoietic progenitor cells. Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. Content provided by iHOP - Information Hyperlinked over Proteins...Gene 24883 at NCBI
iHOP says (Rattus norvegicus):
We investigated whether two WT1 splice variants lacking or including a three-amino-acid (KTS) insertion between the third and fourth zinc finger in the DNA- binding domain could repress the IR promoter in vitro. Finally, ectopic expression of WT1 attenuated apoptosis, and coexpression of Par-4 but not a leucine zipperless mutant of Par-4 rescued the cells from the antiapoptotic effect of WT1. Deletional mapping indicated that distinct regions of the IR promoter mediated the effects of the two isoforms and DNaseI footprint analysis identified potential WT1 binding sites within these regions. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Wilms' tumor protein (WT33); Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'
Entry for target species Mus musculus: Gene 22431STRING says (Mus musculus):
Wilms tumor homolog; Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'
STRING says (Rattus norvegicus):
Wilms' tumor protein homolog; Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'
chr3 34545163 34545172 [@E2F+232:*bp] 844 + E2F1 | Model made for | Mus musculus |
About the matching model:
Entry for target species Mus musculus: Gene 13555Gene 13555 at NCBI
iHOP says (Mus musculus):
Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. By targeting the entire subclass of E2F transcriptional activators we provide direct genetic evidence for their essential role in cell cycle progression, proliferation and development. These observations indicate that E2F transcription factors are regulated by a succession of partner proteins with which they associate during defined stages of the cell cycle. Content provided by iHOP - Information Hyperlinked over Proteins...
Entry for target species Mus musculus: Gene 13555STRING says (Mus musculus):
E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis
chr3 34545069 34545076 [@Church+92:5bp] 975 + Churchill | Model made for | Gallus gallus |
About the matching model:
Gene 395448 at NCBI
iHOP says (-):
Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling. These findings reveal a dynamic role for chch in regulating cell movement and fate during early development. The zinc-finger transcription factor, Churchill (ChCh) has been proposed to regulate cell fate by regulating cell movements during gastrulation in the chick. Content provided by iHOP - Information Hyperlinked over Proteins...
Model's TFs' homologs in target species Mus musculus:
chr3 34545067 34545076 [@MZF1+92:7bp] 835 + MZF1 | Model made for | Homo sapiens |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545069 34545076 [@MZF114+93:5bp] 970 + MZF114 | Model made for | Homo sapiens |
About the matching model:
Model's TFs' homologs in target species Mus musculus:
chr3 34545064 34545073 [@E2F:89:*bp] 841 + E2F | Model made for | Homo sapiens |
About the matching model:
Gene 1869 at NCBI
iHOP says (Homo sapiens):
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. These results suggest a new mechanism for controlling the cell-cycle regulatory activity of E2F1. Differential cell cycle effects induced by E2F1 mutants. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says (Homo sapiens):
Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1); Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate b [...]
Model's TFs' homologs in target species Mus musculus:
13555Gene 13555 at NCBI
iHOP says:
Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. By targeting the entire subclass of E2F transcriptional activators we provide direct genetic evidence for their essential role in cell cycle progression, proliferation and development. These observations indicate that E2F transcription factors are regulated by a succession of partner proteins with which they associate during defined stages of the cell cycle. Content provided by iHOP - Information Hyperlinked over Proteins...
STRING says:
E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis