The current healthcare research agenda in Canada is a more balanced one. There is a strong foundation in discovery of new health knowledge and its translation into the healthcare system. The research agenda prior to this was focused almost exclusively on the creation of new knowledge, with little funding emphasis on the actual implementation in practice or policy. Having this new agenda in healthcare, however, is complex; to be effective it needs to span macro (policy, funding), meso (organizational) and individual (researcher, decision-maker, consumer) levels of the health system which is itself a complex system with competing demands from multiple stakeholders. Adding to this complexity, is an agenda also greatly shaped by a degree of societal accountability (e.g., return on investment of tax dollars earmarked for health research) and priorities (e.g., identified needs for healthcare system improvements).

The Canadian movement for addressing how research influences the healthcare system and patient outcomes emerged in the early 1990s with calls in the literature for the adoption of an evidence-based, decision making culture throughout the healthcare system [e.g., 9]; the National Forum on Health swiftly spurred a similar response at a national level 42. Borne out of these early developments, at the macro level, are knowledge translation agendas currently endorsed by Canada's two major health research funding agencies, the Canadian Institutes of Health Research (CIHR) and Canadian Health Services Research Foundation (CHSRF). Each agency offers their respective definition of knowledge translation. For CIHR, knowledge translation involves "... the exchange, synthesis and ethically-sound application of knowledge – within a complex system of interactions among researchers and users – to accelerate the capture of the benefits of research for Canadians" 43. CHSRF uses the phrase knowledge transfer and exchange, defined as "... collaborative problem-solving between researchers and decision makers that happens through linkage and exchange. [It] results in mutual learning through the process of planning, producing, disseminating, and applying existing or new research in decision-making" 44.

Using these definitions, both agencies have established key funding directives to encourage the translation of health research knowledge to ultimately better influence policy and healthcare practice decisions. CIHR stresses accountability in the return on investment of tax dollars that fund Canadian health research 4345. The intent is clear: publicly funded health research should be carried out in the most effective way to facilitate timely translation of research findings into health and fiscal benefits. Since its establishment in 1999, CIHR has increased its funding three-fold in clinical research and twenty-fold in health systems research supporting its knowledge translation mandate 46. Despite these funding increases, there is sentiment that additional funds need to be dedicated to continue to build capacity in the knowledge translation field, and the agency has proposed further developments to its knowledge translation portfolio 247. Consistent with its definition of knowledge transfer and exchange, CHSRF focuses funding on applied health research projects and clearly emphasizes the need for established relationships between researchers, decision- and/or policy-makers to translate research findings to healthcare settings 44. While the role of Canada's funding agencies in the knowledge translation agenda provides a transparent process of tracking health research funds and the impact/outputs of funded research, these positions greatly influence the country's research agenda and shape issues related to timing, translation ethics, and accountability.

While the translation of basic scientific 'bench' discoveries into clinical studies and the translation of clinical studies into improvements in health care practices remain two major obstacles in the health care system, there are no definitive timeframes from Canada's funding agencies to promote research advancement that addresses these limitations. Indeed, it may take years or decades before a body of research accumulates to provide an ethical and sound direction for health system impact. Further, research advances often involve the coordination of contributions from more than one scientific field (e.g., basic and clinical researchers from nanotechnology, engineering, medicine, etc.). CIHR accounts for this important timing issue in its caveat of 'ethically-sound application' in its definition, but the message may not be clear enough to researchers when considered alongside the agency's expectations for knowledge translation. In a recent paper, the notion of judicious translation was brought forth by CIHR which fits well with this dilemma 2. In their article, Graham and Tetroe stress that "while researchers are encouraged to translate the results of their studies, they need to be thoughtful about their message and who the appropriate audience is for this message" [2; pg 21].

We agree with this position; there is indeed an important ethical component to the knowledge translation agenda that should not be diminished in the effort to close the gap between 'bench and bedside'. The knowledge translation movement in healthcare can give rise to good-intentioned researchers, decision-makers, and policy-makers prematurely implementing evidence and/or interventions when there is an insufficient knowledge base to be confident in its impact; a concern and reality already echoed in the literature 345648. The sense of urgency to translate for public greater good and system improvements should be tempered with clear messages that translation is an ethically-bound process that should be judiciously appraised. In this sense, a distinction is made between what knowledge translation is to healthcare (e.g., translating evidence into healthcare practice to promote system improvements) versus what knowledge translation is to health research (e.g., translating research evidence into the scientific community via publication for scrutiny and/or translating evidence into healthcare practice for study). A natural debate that emerges from this distinction, but is debatable beyond the scope of this paper, is the application of best available evidence versus best evidence.

The emphasis by Canada's funding agencies on engaged activities between researchers and decision- and policy-makers to promote research translation into health benefits carries accountability issues and concerns regarding scope of practice. There is potential for considerable impact on these stakeholders. Little research has empirically examined the activities of Canadian health researchers, and whether these actually align with the country's current funding agendas 49. Of concern is the potential tension between funding agency directives and the system that health researchers function in, an environment that expects researchers to ascend through the academic ranks via established publication and grant dollar benchmarks. Effort afforded to establishing connectivity with and products essential to decision- and policy-makers for translation is under-rewarded, if unrewarded, by university tenure and promotion systems carrying the potential of unintended adverse career effects 4150. The same situation can be afforded to decision- and policy-makers who are evaluated by performance standards that are not well-aligned with funding agency directives that encourage/expect involvement in the research process and translation efforts whose products often extend beyond formal, evaluative time spans in healthcare organizations.

To meet the contemporary demands of Canadian funding agencies and those of university tenure and promotion, researchers need to consider a portfolio that includes traditional knowledge translation expectations (scholarly outputs such as peer-reviewed publications) and applied knowledge translation activity (engaged interactions with decision- and policy-makers) 515253. Academic institutions' values need to evolve to become more utilitarian; knowledge discovery cannot be solely regarded and rewarded via traditional knowledge translation activity, but should extend to a more utilitarian standpoint where knowledge discovery is 'hand-in-hand' with potential implementation. The same philosophy can be applied to decision- and policy-makers who find themselves at odds with how to manage their portfolios. This potential solution, however, only targets individual accountability. Accountability targeted at the organizational level should also be expected. Within the knowledge translation agenda are calls for the recognition and examination of organizational factors (e.g., leadership structure, hospital classification) and environmental factors (e.g., the healthcare delivery team, organizational culture, administrative personnel) that shape the innovation implementation 243839565758. This call should also include the examination of institutions that employ the researchers (i.e., academia) and decision- and policy-makers (i.e., hospitals and government) as these stakeholders are also directly embedded in the organizational and environmental systems within the healthcare system. Employer promoted professional development and evaluation systems need to be re-examined and reconstructed to reflect current trends in the healthcare research agenda 5253. Professional development should include organization-created opportunities for relationship development and skill-building related to research application. In Canada, several examples exist to strengthen capacity in developing relationships between researchers and decision-/policy-makers (e.g., community-university partnerships [CUP] programs) and developing leadership and skills to better use research information in the healthcare system, including SEARCH Canada (Swift, Efficient Application of Research in Community Health) 54 and the EXTRA (Executive Training for Research Application) programs 55. These opportunities, however, need to be more consistent in the Canadian system as a means of formal markers for professional development and work scope.