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Proteomic applications in medicine

 Guest editors: Sabine Bahn and Paul Guest

The application of proteomic technologies to clinical specimens has the potential to revolutionize the treatment of many diseases. From biomarker discovery and validation to personalized therapies, proteomic techniques allow a greater understanding of the dynamic processes involved in disease, increasing the power of prediction, diagnosis and prognosis. Genome Medicine presents a series dedicated to proteomic applications in medicine.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The guest editor declares no competing interests.

  1. Research

    Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy

    Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel ...

    Chantal A Mutsaers, Douglas J Lamont, Gillian Hunter, Thomas M Wishart and Thomas H Gillingwater

    Genome Medicine 2013 5:95

    Published on: 18 October 2013

  2. Opinion

    The emergence of top-down proteomics in clinical research

    Proteomic technology has advanced steadily since the development of 'soft-ionization' techniques for mass-spectrometry-based molecular identification more than two decades ago. Now, the large-scale analysis of...

    John P Savaryn, Adam D Catherman, Paul M Thomas, Michael M Abecassis and Neil L Kelleher

    Genome Medicine 2013 5:53

    Published on: 27 June 2013

  3. Review

    Proteomic profiling in schizophrenia: enabling stratification for more effective treatment

    Schizophrenia is a heterogeneous psychiatric disorder characterized by an array of clinical manifestations. Although the best known manifestations include serious effects on mood and behavior, patients can als...

    Paul C Guest, Daniel Martins-de-Souza, Emanuel Schwarz, Hassan Rahmoune, Murtada Alsaif, Jakub Tomasik, Christoph W Turck and Sabine Bahn

    Genome Medicine 2013 5:25

    Published on: 26 March 2013

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