Hypoxia and oxidative stress in breast cancer

Roy Bicknell

Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations

Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiothera...

Authors: Kaye J Williams, Rachel L Cowen and Ian J Stratford

Citation: Breast Cancer Research 2001 3:328

Content type: Review Published on: 7 August 2001
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Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer

Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in viv...

Authors: Nicholas S Brown and Roy Bicknell

Citation: Breast Cancer Research 2001 3:323

Content type: Review Published on: 23 July 2001
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Hypoxia and oxidative stress in breast cancer Hypoxia and tumourigenesis

The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apopt...

Authors: Helen J Knowles and Adrian L Harris

Citation: Breast Cancer Research 2001 3:318

Content type: Review Published on: 17 July 2001
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Hypoxia and oxidative stress in breast cancer Hypoxia signalling pathways

Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a r...

Authors: Christopher W Pugh, Jonathan Gleadle and Patrick H Maxwell

Citation: Breast Cancer Research 2001 3:313

Content type: Review Published on: 16 July 2001
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Hypoxia and oxidative stress in breast cancer

Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations

Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer

Hypoxia and oxidative stress in breast cancer Hypoxia and tumourigenesis

Hypoxia and oxidative stress in breast cancer Hypoxia signalling pathways