Ageing, autoimmunity and arthritis

ar_Ageing

Ageing, autoimmunity and arthritis: Senescence of the B cell compartment – implications for humoral immunity

Immunosenescence is associated with a decline in both T and B lymphocyte function. Although aged individuals have normal numbers of B cells in the periphery and are capable of mounting robust humoral responses...

Authors: Sara A Johnson and John C Cambier

Citation: Arthritis Res Ther 2004 6:131

Content type: Review Published on: 10 May 2004
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Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing – a biochemical paradigm for the ageing immune system

It is widely accepted that cell-mediated immune functions decline with age, rendering an individual more susceptible to infection and possibly cancer, as well as to age-associated autoimmune diseases. The exac...

Authors: Tamàs Fülöp Jr, Anis Larbi, Gilles Dupuis and Graham Pawelec

Citation: Arthritis Res Ther 2003 5:290

Content type: Review Published on: 16 October 2003
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Ageing, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation

Rheumatoid arthritis (RA), like many other autoimmune syndromes, is a disease of adults, with the highest incidence rates reported in the elderly. The immune system undergoes profound changes with advancing ag...

Authors: Jörg J Goronzy and Cornelia M Weyand

Citation: Arthritis Res Ther 2003 5:225

Content type: Review Published on: 8 August 2003
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Ageing, autoimmunity and arthritis: An introduction

Authors: Andrew P Cope

Citation: Arthritis Res Ther 2003 5:223

Content type: Review Published on: 8 August 2003
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Ageing, autoimmunity and arthritis

Ageing, autoimmunity and arthritis: Senescence of the B cell compartment – implications for humoral immunity

Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing – a biochemical paradigm for the ageing immune system

Ageing, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation

Ageing, autoimmunity and arthritis: An introduction