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Added Value Chemicals and Biofuels

Edited by Prof Akihiko Kondo

To ensure a reliable future source of added value chemicals and energy, the utilization of sustainable biomass has considerable advantages over petroleum-based sources. Microbial Cell Factories presents this ongoing series to cover the development of microorganisms for the production of various added value chemicals and advanced biofuels from biomass. Potential topics include, but are not limited, to engineering microbial strains with high biomass hydrolysis activity, high product yield, productivities and titers, ability to use many carbon sources, and resistance to toxic compounds released during the pretreatment of biomass.

Please see here for further details, including how to submit your new work to the series.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

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  1. Research

    Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae

    Microbial production of monoterpenes provides a promising substitute for traditional chemical-based methods, but their production is lagging compared with sesquiterpenes. Geraniol, a valuable monoterpene alcoh...

    Jianzhi Zhao, Chen Li, Yan Zhang, Yu Shen, Jin Hou and Xiaoming Bao

    Microbial Cell Factories 2017 16:17

    Published on: 31 January 2017

  2. Research

    Characterisation of the broad substrate specificity 2-keto acid decarboxylase Aro10p of Saccharomyces kudriavzevii and its implication in aroma development

    The yeast amino acid catabolism plays an important role in flavour generation since higher alcohols and acetate esters, amino acid catabolism end products, are key components of overall flavour and aroma in fe...

    Jiri Stribny, Gabriele Romagnoli, Roberto Pérez-Torrado, Jean-Marc Daran and Amparo Querol

    Microbial Cell Factories 2016 15:51

    Published on: 12 March 2016

  3. Research

    ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae

    With increasing concern about the environmental impact of a petroleum based economy, focus has shifted towards greener production strategies including metabolic engineering of microbes for the conversion of pl...

    Sarah Rodriguez, Charles M. Denby, T. Van Vu, Edward E. K. Baidoo, George Wang and Jay D. Keasling

    Microbial Cell Factories 2016 15:48

    Published on: 3 March 2016

  4. Research

    Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities

    Several plant diterpenes have important biological properties. Among them, forskolin is a complex labdane-type diterpene whose biological activity stems from its ability to activate adenylyl cyclase and to ele...

    Codruta Ignea, Efstathia Ioannou, Panagiota Georgantea, Fotini A. Trikka, Anastasia Athanasakoglou, Sofia Loupassaki, Vassilios Roussis, Antonios M. Makris and Sotirios C. Kampranis

    Microbial Cell Factories 2016 15:46

    Published on: 26 February 2016

  5. Research

    Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

    PM100117 and PM100118 are glycosylated polyketides with remarkable antitumor activity, which derive from the marine symbiotic actinobacteria Streptomyces caniferus GUA-...

    Raúl García Salcedo, Carlos Olano, Cristina Gómez, Rogelio Fernández, Alfredo F. Braña, Carmen Méndez, Fernando de la Calle and José A. Salas

    Microbial Cell Factories 2016 15:44

    Published on: 22 February 2016

  6. Research

    Key role of lipid management in nitrogen and aroma metabolism in an evolved wine yeast strain

    Fermentative aromas play a key role in the organoleptic profile of young wines. Their production depends both on yeast strain and fermentation conditions. A present-day trend in the wine industry consists in d...

    Stéphanie Rollero, Jean-Roch Mouret, Isabelle Sanchez, Carole Camarasa, Anne Ortiz-Julien, Jean-Marie Sablayrolles and Sylvie Dequin

    Microbial Cell Factories 2016 15:32

    Published on: 9 February 2016

  7. Research

    High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii

    Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism. In ...

    Veerle E. T. Maervoet, Sofie L. De Maeseneire, Fatma G. Avci, Joeri Beauprez, Wim K. Soetaert and Marjan De Mey

    Microbial Cell Factories 2016 15:23

    Published on: 28 January 2016

  8. Research

    Metabolic engineering of Escherichia coli for the production of cinnamaldehyde

    Plant parasitic nematodes are harmful to agricultural crops and plants, and may cause severe yield losses. Cinnamaldehyde, a volatile, yellow liquid commonly used as a flavoring or food additive, is increasing...

    Hyun Bae Bang, Yoon Hyeok Lee, Sun Chang Kim, Chang Keun Sung and Ki Jun Jeong

    Microbial Cell Factories 2016 15:16

    Published on: 19 January 2016

  9. Research

    Metabolic engineering of Clostridium cellulolyticum for the production of n-butanol from crystalline cellulose

    Sustainable alternatives for the production of fuels and chemicals are needed to reduce our dependency on fossil resources and to avoid the negative impact of their excessive use on the global climate. Lignoce...

    Stefan Marcus Gaida, Andrea Liedtke, Andreas Heinz Wilhelm Jentges, Benedikt Engels and Stefan Jennewein

    Microbial Cell Factories 2016 15:6

    Published on: 13 January 2016

  10. Research

    Gallic acid production under anaerobic submerged fermentation by two bacilli strains

    Tannase is an enzyme that catalyses the breakdown of ester bonds in gallotannins such as tannic acid. In recent years, the interest on bacterial tannases has increased b...

    Pedro Aguilar-Zárate, Mario A. Cruz, Julio Montañez, Raúl Rodríguez-Herrera, Jorge E. Wong-Paz, Ruth E. Belmares and Cristóbal N. Aguilar

    Microbial Cell Factories 2015 14:209

    Published on: 30 December 2015

  11. Review

    ATP regulation in bioproduction

    Adenosine-5′-triphosphate (ATP) is consumed as a biological energy source by many intracellular reactions. Thus, the intracellular ATP supply is required to maintain cellular ho...

    Kiyotaka Y. Hara and Akihiko Kondo

    Microbial Cell Factories 2015 14:198

    Published on: 10 December 2015

  12. Research

    Deletion of the 2-acyl-glycerophosphoethanolamine cycle improve glucose metabolism in Escherichia coli strains employed for overproduction of aromatic compounds

    As a metabolic engineering tool, an adaptive laboratory evolution (ALE) experiment was performed to increase the specific growth rate (µ) in an Escherichia coli strain lacking PTS, originally engineered to increa...

    César Aguilar, Noemí Flores, Fernando Riveros-McKay, Diana Sahonero-Canavesi, Susy Beatriz Carmona, Otto Geiger, Adelfo Escalante and Francisco Bolívar

    Microbial Cell Factories 2015 14:194

    Published on: 1 December 2015

  13. Research

    Engineering Corynebacterium glutamicum for the production of 2,3-butanediol

    2,3-Butanediol is an important bulk chemical with a wide range of applications. In bacteria, this metabolite is synthesised from pyruvate via a three-step pathway involving α-acetolactate synthase, α-acetolact...

    Dušica Radoš, Ana Lúcia Carvalho, Stefan Wieschalka, Ana Rute Neves, Bastian Blombach, Bernhard J. Eikmanns and Helena Santos

    Microbial Cell Factories 2015 14:171

    Published on: 29 October 2015

  14. Research

    Genetic and nutrient modulation of acetyl-CoA levels in Synechocystis for n-butanol production

    There is a strong interest in using photosynthetic cyanobacteria as production hosts for biofuels and chemicals. Recent work has shown the benefit of pathway engineering, enzyme tolerance, and co-factor usage ...

    Josefine Anfelt, Danuta Kaczmarzyk, Kiyan Shabestary, Björn Renberg, Johan Rockberg, Jens Nielsen, Mathias Uhlén and Elton P. Hudson

    Microbial Cell Factories 2015 14:167

    Published on: 16 October 2015

  15. Research

    Metabolic engineering of Escherichia coli into a versatile glycosylation platform: production of bio-active quercetin glycosides

    Flavonoids are bio-active specialized plant metabolites which mainly occur as different glycosides. Due to the increasing market demand, various biotechnological approaches have been developed which use Escherich...

    Frederik De Bruyn, Maarten Van Brempt, Jo Maertens, Wouter Van Bellegem, Dries Duchi and Marjan De Mey

    Microbial Cell Factories 2015 14:138

    Published on: 16 September 2015

  16. Research

    Three-pathway combination for glutathione biosynthesis in Saccharomyces cerevisiae

    Glutathione (GSH), a pivotal non-protein thiol, can be biosynthesized through three pathways in different organisms: (1) two consecutive enzymatic reactions catalyzed by γ-glutamylcysteine synthetase (Gsh1 or ...

    Liang Tang, Weiwei Wang, Wenlong Zhou, Kai Cheng, Yan Yang, Minzhi Liu, Kedi Cheng and Wei Wang

    Microbial Cell Factories 2015 14:139

    Published on: 16 September 2015

  17. Research

    Optimization of ethylene glycol production from (d)-xylose via a synthetic pathway implemented in Escherichia coli

    Ethylene glycol (EG) is a bulk chemical that is mainly used as an anti-freezing agent and a raw material in the synthesis of plastics. Production of commercial EG currently exclusively relies on chemical synth...

    Ceren Alkim, Yvan Cam, Debora Trichez, Clément Auriol, Lucie Spina, Amélie Vax, François Bartolo, Philippe Besse, Jean Marie François and Thomas Walther

    Microbial Cell Factories 2015 14:127

    Published on: 4 September 2015

  18. Research

    Developing a high-throughput screening method for threonine overproduction based on an artificial promoter

    l-Threonine is an important amino acid for animal feed. Though the industrial fermentation technology of threonine achieved a very high level, t...

    Ya’nan Liu, Qinggang Li, Ping Zheng, Zhidan Zhang, Yongfei Liu, Cunmin Sun, Guoqiang Cao, Wenjuan Zhou, Xiaowei Wang, Dawei Zhang, Tongcun Zhang, Jibin Sun and Yanhe Ma

    Microbial Cell Factories 2015 14:121

    Published on: 22 August 2015

  19. Research

    Enhanced 2,3-butanediol production from biodiesel-derived glycerol by engineering of cofactor regeneration and manipulating carbon flux in Bacillus amyloliquefaciens

    Bacillus amyloliquefaciens B10-127 exhibited an excellent ability for industrial-scale microbial fermentation of 2,3-butanediol (2,3-BD) from biodiesel-derived glycerol. However, the a...

    Taowei Yang, Zhiming Rao, Xian Zhang, Meijuan Xu, Zhenghong Xu and Shang-Tian Yang

    Microbial Cell Factories 2015 14:122

    Published on: 22 August 2015

  20. Review

    Yeast as a cell factory: current state and perspectives

    The yeast Saccharomyces cerevisiae is one of the oldest and most frequently used microorganisms in biotechnology with successful applications in the production of both bulk and fine chemicals. Yet, yeast research...

    Martin Kavšček, Martin Stražar, Tomaž Curk, Klaus Natter and Uroš Petrovič

    Microbial Cell Factories 2015 14:94

    Published on: 30 June 2015

  21. Research

    Overexpression of a bifunctional enzyme, CrtS, enhances astaxanthin synthesis through two pathways in Phaffia rhodozyma

    A moderate-temperature, astaxanthin-overproducing mutant strain (termed MK19) of Phaffia rhodozyma was generated in our laboratory. The intracellular astaxanthin content of MK19 was 17-fold higher than that of wi...

    Shuang Chi, Yanfeng He, Jie Ren, Qian Su, Xingchao Liu, Zhi Chen, Mingan Wang, Ying Li and Jilun Li

    Microbial Cell Factories 2015 14:90

    Published on: 18 June 2015

  22. Research

    Macaúba (Acrocomia aculeata) cake from biodiesel processing: a low-cost substrate to produce lipases from Moniliella spathulata R25L270 with potential application in the oleochemical industry

    Biodiesel industry wastes were evaluated as supplements for lipase production by Moniliella spathulata R25L270, which is newly identified yeast with great lipolytic potenti...

    Lívia T A Souza, Jamil S Oliveira, Marina Q R B Rodrigues, Vera L dos Santos, Benevides C Pessela and Rodrigo R Resende

    Microbial Cell Factories 2015 14:87

    Published on: 16 June 2015

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