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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR. 

Page 2 of 7

  1. The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate 20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to treatment employs multiple mecha...

    Authors: Fengzhi Li, Ieman A. M. Aljahdali, Renyuan Zhang, Kent L. Nastiuk, John J. Krolewski and Xiang Ling
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:254
    Content type: Review Published on:

  2. Primary liver cancer (PLC) is a common malignancy with high morbidity and mortality. Poor prognosis and easy recurrence on PLC patients calls for optimizations of the current conventional treatments and the ex...

    Authors: Yuanyuan Zheng, Yan Li, Jiao Feng, Jingjing Li, Jie Ji, Liwei Wu, Qiang Yu, Weiqi Dai, Jianye Wu, Yingqun Zhou and Chuanyong Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:250
    Content type: Review Published on:

  3. Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, ...

    Authors: Daniel Otero-Albiol and Amancio Carnero
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:243
    Content type: Review Published on:

  4. Immunotherapeutic treatments are gaining attention due to their effective anti-tumor response. Particularly, the revolution of immune checkpoint inhibitors (ICIs) produces promising outcomes for various cancer...

    Authors: Krishnapriya M. Varier, Hemavathi Dhandapani, Wuling Liu, Jialei Song, Chunlin Wang, Anling Hu, Yaacov Ben-David, Xiangchun Shen, Yanmei Li and Babu Gajendran
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:242
    Content type: Review Published on:

  5. As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effec...

    Authors: Wen Jiang, Jin-Wei Hu, Xu-Ran He, Wei-Lin Jin and Xin-Yang He
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:241
    Content type: Review Published on:

  6. The yearly Think Tank Meeting of the Italian Network for Tumor Biotherapy (NIBIT) Foundation, brings together in Siena, Tuscany (Italy), experts in immuno-oncology to review the learnings from current immunoth...

    Authors: Michele Maio, Michael Lahn, Anna Maria Di Giacomo, Alessia Covre, Luana Calabrò, Ramy Ibrahim and Bernard Fox
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:240
    Content type: Meeting Report Published on:

  8. Extracellular vesicles (EVs) containing specific subsets of functional biomolecules are released by all cell types and analysis of circulating EVs can provide diagnostic and prognostic information. To date, li...

    Authors: Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro, Giulia Bertolini, Ilaria Petraroia, Giovanni Centonze, Anna Maria Ferretti, Paola Suatoni, Ugo Pastorino, Orazio Fortunato and Gabriella Sozzi
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:237
    Content type: Research Published on:

  10. Neutrophils are the most abundant type of white blood cells circulating throughout the bloodstream and are often considered the frontline defenders in innate immunity. However, neutrophils are increasingly bei...

    Authors: Livia Ronchetti, Nouha Setti Boubaker, Maddalena Barba, Patrizia Vici, Aymone Gurtner and Giulia Piaggio
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:231
    Content type: Review Published on:

  11. Tumor immunity consists of various types of cells, which serve an important role in antitumor therapy. The gastrointestinal tract is colonized by trillions of microorganisms, which form the gut microbiota. In ...

    Authors: Xinyi Liu, Yanjie Chen, Si Zhang and Ling Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:221
    Content type: Review Published on:

  12. It has been well documented that the tumor microenvironment (TME) plays a key role in the promotion of drug resistance, the support of tumor progression, invasiveness, metastasis, and even the maintenance of a...

    Authors: Pablo Hernández-Camarero, Elena López-Ruiz, Juan Antonio Marchal and Macarena Perán
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:217
    Content type: Review Published on:

  13. Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes...

    Authors: Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters and Evelien L. J. M. Smits
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:213
    Content type: Review Published on:

  14. Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to ...

    Authors: Yali Wang, Kun Zheng, Yongbiao Huang, Hua Xiong, Jinfang Su, Rui Chen and Yanmei Zou
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:211
    Content type: Review Published on:

  15. Nasopharyngeal carcinoma (NPC) represents a molecularly paradigmatic tumor given the complex diversity of environmental as well as host dependent factors that are closely implicated in tissue transformation an...

    Authors: Ramon Yarza, Mateo Bover, Maria Teresa Agulló-Ortuño and Lara Carmen Iglesias-Docampo
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:202
    Content type: Review Published on:

  16. Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical outcome. The significance of hypoxia in the development of resistance to radiotherapy has been recognized for decades...

    Authors: Irma Telarovic, Roland H. Wenger and Martin Pruschy
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:197
    Content type: Review Published on:

  17. Bcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splic...

    Authors: Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin, Xuetian Zhang, Yupei Wang, Xiaodong Xie, Qiang Li, Cuixia Di and Hong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:194
    Content type: Review Published on:

  18. Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcr...

    Authors: Vid Mlakar, Edouard Morel, Simona Jurkovic Mlakar, Marc Ansari and Fabienne Gumy-Pause
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:189
    Content type: Review Published on:

  19. Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its early promising results in decre...

    Authors: Revati Sharma, Elif Kadife, Mark Myers, George Kannourakis, Prashanth Prithviraj and Nuzhat Ahmed
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:186
    Content type: Review Published on:

  20. Colorectal cancer (CRC) is a complex and heterogeneous disease, characterized by dismal prognosis and low survival rate in the advanced (metastatic) stage. During the last decade, the establishment of novel pr...

    Authors: Erika Durinikova, Kristi Buzo and Sabrina Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:185
    Content type: Review Published on:

  21. The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regula...

    Authors: Hao Zhang, Ziyu Dai, Wantao Wu, Zeyu Wang, Nan Zhang, Liyang Zhang, Wen-Jing Zeng, Zhixiong Liu and Quan Cheng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:184
    Content type: Review Published on:

  22. Colorectal cancer (CRC), despite the advances in screening and surveillance, remains the second most common cause of cancer death worldwide. The biological inadequacy of pre-clinical models to fully recapitula...

    Authors: Giulia Rizzo, Andrea Bertotti, Simonetta Maria Leto and Stefania Vetrano
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:178
    Content type: Review Published on:

  23. Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the emergence of chemoresistance in cancer has significant impacts on t...

    Authors: Guo-Hua Li, Qiang Qu, Ting-Ting Qi, Xin-Qi Teng, Hai-Hong Zhu, Jiao-Jiao Wang, Qiong Lu and Jian Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:174
    Content type: Review Published on:

  24. Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide, few drugs are available for its clinical treatment. However, in recent years, major breakthroughs have been made in the...

    Authors: Xiang-Yuan Luo, Kong-Ming Wu and Xing-Xing He
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:172
    Content type: Review Published on:

  25. Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the single-cell level that has been widely used due to its unprecedented high resolution. In the present review, we outline the ...

    Authors: Lvyuan Li, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Qianjin Liao, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:163
    Content type: Review Published on:

  26. Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment and promotes cancer progression and resistance to therapy. Many studies reported the essential role of hypoxia in regul...

    Authors: Simona D’Aguanno, Fabiana Mallone, Marco Marenco, Donatella Del Bufalo and Antonietta Moramarco
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:159
    Content type: Review Published on:

  27. Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death (RCD) or programmed cell death (PCD) is not only essential in embry...

    Authors: Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang and Mei Yi
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:153
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:296

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:219

  28. Transforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic function at early stages of cancer formation and pro-tumorigenic effects at later stages promoting cancer metastasis. A ...

    Authors: Chao-Hui Chang and Siim Pauklin
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:152
    Content type: Review Published on:

  29. BACE1 and BACE2 belong to a class of proteases called β-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as t...

    Authors: Francesco Farris, Vittoria Matafora and Angela Bachi
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:147
    Content type: Review Published on:

  30. The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized b...

    Authors: Fenghua Tan, Mengyao Zhao, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:146
    Content type: Review Published on:

  31. Tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2) are two homologous proteins that are gaining increasing importance due to their implication in multiple pathways and diseases such as cancer. TNKS1/2 interact with a...

    Authors: Esteban Zamudio-Martinez, Ana Belén Herrera-Campos, Alberto Muñoz, José Manuel Rodríguez-Vargas and F. Javier Oliver
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:144
    Content type: Review Published on:

  32. Breast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment ...

    Authors: Xueqi Yan, Yinghong Xie, Fan Yang, Yijia Hua, Tianyu Zeng, Chunxiao Sun, Mengzhu Yang, Xiang Huang, Hao Wu, Ziyi Fu, Wei Li, Shiping Jiao and Yongmei Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:142
    Content type: Review Published on:

  33. The conventional method used to obtain a tumor biopsy for hepatocellular carcinoma (HCC) is invasive and does not evaluate dynamic cancer progression or assess tumor heterogeneity. It is thus imperative to cre...

    Authors: Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu and Chuanyong Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:140
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:229

  34. Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy. Semaphorins, a family of a...

    Authors: Elisabetta Valentini, Marta Di Martile, Donatella Del Bufalo and Simona D’Aguanno
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:131
    Content type: Review Published on:

  35. The circadian system temporally regulates physiology to maintain homeostasis. Co-opting and disrupting circadian signals appear to be distinct attributes that are functionally important for the development of ...

    Authors: Elizabeth Cash, Sandra Sephton, Cassandra Woolley, Attia M. Elbehi, Anu R. I., Bene Ekine-Afolabi and Victor C. Kok
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:119
    Content type: Review Published on:

  36. High grade serous ovarian cancer (HGSOC) is among the deadliest human cancers and its prognosis remains extremely poor. Tumor heterogeneity and rapid acquisition of resistance to conventional chemotherapeutic ...

    Authors: Camilla Nero, Giuseppe Vizzielli, Domenica Lorusso, Eleonora Cesari, Gennaro Daniele, Matteo Loverro, Giovanni Scambia and Claudio Sette
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:116
    Content type: Review Published on:

  37. MicroRNAs (miRNAs) regulate the expression of their target genes post-transcriptionally; thus, they are deeply involved in fundamental biological processes. miRNA clusters contain two or more miRNA-encoding ge...

    Authors: Kosuke Yoshida, Akira Yokoi, Yusuke Yamamoto and Hiroaki Kajiyama
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:112
    Content type: Review Published on:

  38. Deciphering extracellular matrix (ECM) composition and architecture may represent a novel approach to identify diagnostic and therapeutic targets in cancer. Among the ECM components, fibronectin and its fibril...

    Authors: Sheila Spada, Annalisa Tocci, Francesca Di Modugno and Paola Nisticò
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:102
    Content type: Review Published on:

  39. Cancer occurs in a complex tissue environment, and its progression depends largely on the tumour microenvironment (TME). The TME has a highly complex and comprehensive system accompanied by dynamic changes and...

    Authors: Haoze Li, Lihong Zhou, Jing Zhou, Qi Li and Qing Ji
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:97
    Content type: Review Published on:

  40. Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations ...

    Authors: Yijie Zhang, Dan Wang, Miao Peng, Le Tang, Jiawei Ouyang, Fang Xiong, Can Guo, Yanyan Tang, Yujuan Zhou, Qianjin Liao, Xu Wu, Hui Wang, Jianjun Yu, Yong Li, Xiaoling Li, Guiyuan Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:81
    Content type: Review Published on:

  41. Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies. Response rates are however suboptimal, and despite cons...

    Authors: Allan Relecom, Maysaloun Merhi, Varghese Inchakalody, Shahab Uddin, Darawan Rinchai, Davide Bedognetti and Said Dermime
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:74
    Content type: Review Published on:

  42. In hepatocellular carcinoma patients, due to the microenvironmental specificity of liver, the tumor microenvironment exhibits high immunosuppression and drug resistance, resulting in excessive or insufficient ...

    Authors: Jingyi Zhou, Weiyu Wang and Qi Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:73
    Content type: Review Published on:

  43. Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunit...

    Authors: Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:60
    Content type: Review Published on:

  44. Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3’ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a singl...

    Authors: Yi Zhang, Lian Liu, Qiongzi Qiu, Qing Zhou, Jinwang Ding, Yan Lu and Pengyuan Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:51
    Content type: Review Published on:

  45. Recent scientific advances have greatly enhanced our understanding of the complex link between the gut microbiome and cancer. Gut dysbiosis is an imbalance between commensal and pathogenic bacteria and the pro...

    Authors: Yanshan Ge, Xinhui Wang, Yali Guo, Junting Yan, Aliya Abuduwaili, Kasimujiang Aximujiang, Jie Yan and Minghua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:42
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:334

  46. The stimulator of interferon genes (STING) connects microbial cytosolic sensing with host cell effector functions. STING signaling plays a central role in cyclic dinucleotides (CDNs) and DNA sensing to induce ...

    Authors: Qiongyuan Hu, Quan Zhou, Xuefeng Xia, Lihua Shao, Meng Wang, Xiaofeng Lu, Song Liu and Wenxian Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:39
    Content type: Review Published on:

  47. Head and neck squamous cell carcinoma (HNSCC) is one of the main malignant tumours affecting human health, mainly due to delayed diagnosis and high invasiveness. Extracellular vehicles (EVs) are membranous ves...

    Authors: Xueying Wang, Junnan Guo, Pingyang Yu, Lunhua Guo, Xionghui Mao, Junrong Wang, Susheng Miao and Ji Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:35
    Content type: Review Published on:

  48. Solid tumors often grow in a micro-environment characterized by < 2% O2 tension. This condition, together with the aberrant activation of specific oncogenic patwhays, increases the amount and activity of the hypo...

    Authors: Muhlis Akman, Dimas Carolina Belisario, Iris Chiara Salaroglio, Joanna Kopecka, Massimo Donadelli, Enrico De Smaele and Chiara Riganti
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:28
    Content type: Review Published on:

  49. The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progressi...

    Authors: Piera Tocci, Giovanni Blandino and Anna Bagnato
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:27
    Content type: Review Published on:

  50. With the success of immune checkpoint inhibitors (ICIs), significant progress has been made in the field of cancer immunotherapy. Despite the long-lasting outcomes in responders, the majority of patients with ...

    Authors: Bin Wang, Qin Zhao, Yuyu Zhang, Zijing Liu, Zhuangzhuang Zheng, Shiyu Liu, Lingbin Meng, Ying Xin and Xin Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:24
    Content type: Review Published on: