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Systems physiology, pharmacology and medicine Section edited by Christina CHan

This section covers the analysis and modeling of complex systems to better understand humans and animal biology, in particular with regard to human health and disease.

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1.

Database   Open Access

A comprehensive map of the influenza A virus replication cycle

Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano, Yoshihiro Kawaoka BMC Systems Biology 2013, 7:97 (2 October 2013)

Abstract | Provisional PDF

2.

Research article   Open Access

The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models

Sirus Palsson, Timothy P Hickling, Erica L Bradshaw-Pierce, Michael Zager, Karin Jooss, Peter J O¿Brien, Mary E Spilker, Bernhard O Palsson, Paolo Vicini BMC Systems Biology 2013, 7:95 (28 September 2013)

Abstract | Provisional PDF | PubMed

3.

Research article   Open Access

Identification of upstream regulators for prognostic expression signature genes in colorectal cancer

Taejeong Bae, Kyoohyoung Rho, Jin Woo Choi, Katsuhisa Horimoto, Wankyu Kim, Sunghoon Kim BMC Systems Biology 2013, 7:86 (4 September 2013)

Abstract | Full text | PDF | PubMed

4.

Research article   Open Access

Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25

Asfar S Azmi, Aliccia Bollig-Fischer, Bin Bao, Bum-Joon Park, Sun-Hye Lee, Gyu Yong-Song, Gregory Dyson, Chandan K Reddy, Fazlul H Sarkar, Ramzi M Mohammad BMC Systems Biology 2013, 7:85 (3 September 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

Research article   Open Access

Post-translational regulation enables robust p53 regulation

Yong-Jun Shin, Kai-Yuan Chen, Ali H Sayed, Brandon Hencey, Xiling Shen BMC Systems Biology 2013, 7:83 (30 August 2013)

Abstract | Full text | PDF | PubMed

6.

Methodology article   Open Access

Computational estimation of tricarboxylic acid cycle fluxes using noisy NMR data from cardiac biopsies

Hannes Hettling, David J C Alders, Jaap Heringa, Thomas W Binsl, A B Groeneveld, Johannes H G M van Beek BMC Systems Biology 2013, 7:82 (21 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

Research article   Open Access Highly Accessed

Rule–based regulatory and metabolic model for Quorum sensing in P. aeruginosa

Nadine S Schaadt, Anke Steinbach, Rolf W Hartmann, Volkhard Helms BMC Systems Biology 2013, 7:81 (21 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

Research article   Open Access

Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder

Ruoting Yang, Bernie J Daigle Jr, Seid Y Muhie, Rasha Hammamieh, Marti Jett, Linda Petzold, Francis J Doyle BMC Systems Biology 2013, 7:80 (20 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

Research article   Open Access

Transdifferentiation of pancreatic cells by loss of contact-mediated signaling

Walter de Back, Roland Zimm, Lutz Brusch BMC Systems Biology 2013, 7:77 (13 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

Research article   Open Access

Computational modelling of bovine ovarian follicle development

Dagmar Iber, Christian Geyter BMC Systems Biology 2013, 7:60 (15 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

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