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1.
Inferring ancient metabolism using ancestral core metabolic models of enterobacteria
David J Baumler, Bing Ma, Jennifer L Reed, Nicole T Perna BMC Systems Biology 2013, 7 :46 (11 June 2013)
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2.
Modular, rule-based modeling for the design of eukaryotic synthetic gene circuits
Mario Marchisio, Moreno Colaiacovo, Ellis Whitehead, Jörg Stelling BMC Systems Biology 2013, 7 :42 (27 May 2013)
Abstract | Full text | PDF
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3.
Probabilistic strain optimization under constraint uncertainty
Mona Yousofshahi, Michael Orshansky, Kyongbum Lee, Soha Hassoun BMC Systems Biology 2013, 7 :29 (29 March 2013)
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4.
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling
Sven EF Borgos, Sergio Bordel, Håvard Sletta, Helga Ertesvåg, Øyvind Jakobsen, Per Bruheim, Trond E Ellingsen, Jens Nielsen, Svein Valla BMC Systems Biology 2013, 7 :19 (11 March 2013)
Abstract | Full text | PDF
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Editor’s summary
Genome-scale metabolic modelling and chemostat experiments identify the genomic features in Pseudomonas fluorescens necessary to develop highly productive strains and optimal conditions for the industrial production of the important polysaccharide gel alginate, currently produced from seaweed.
5.
Glucose-methanol co-utilization in Pichia pastoris studied by metabolomics and instationary 13 C flux analysis
Joel Jordà, Camilo Suarez, Marc Carnicer, Angela ten Pierick, Joseph J Heijnen, Walter van Gulik, Pau Ferrer, Joan Albiol, Aljoscha Wahl BMC Systems Biology 2013, 7 :17 (28 February 2013)
Abstract | Full text | PDF
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6.
Computational codon optimization of synthetic gene for protein expression
Bevan Chung, Dong-Yup Lee BMC Systems Biology 2012, 6 :134 (20 October 2012)
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Editor’s summary
A novel method for codon usage optimization in artificial gene synthesis, optimizing use of both individual codon usage and codon context approaches, is predicted to lead to improved in vitro heterologous protein expression in biotechnology applications.
7.
Gene autoregulation via intronic microRNAs and its functions
Carla Bosia, Matteo Osella, Mariama Baroudi, Davide Corà, Michele Caselle BMC Systems Biology 2012, 6 :131 (10 October 2012)
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8.
Comparative multi-goal tradeoffs in systems engineering of microbial metabolism
David Byrne, Alexandra Dumitriu, Daniel Segrè BMC Systems Biology 2012, 6 :127 (26 September 2012)
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9.
A reconfigurable NAND/NOR genetic logic gate
Angel Goñi-Moreno, Martyn Amos BMC Systems Biology 2012, 6 :126 (18 September 2012)
Abstract | Full text | PDF
| PubMed | Cited on BioMed Central
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Editor’s summary
A novel genetic circuit is proposed and computationally tested that can be dynamically reconfigured to serve as either a NAND or NOR genetic logic gate in either single cells or cell populations.
10.
Designing optimal cell factories: integer programming couples elementary mode analysis with regulation
Christian Jungreuthmayer, Jürgen Zanghellini BMC Systems Biology 2012, 6 :103 (16 August 2012)
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