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	76. 204 Accesses	Research article Proteomic patterns of cervical cancer cell lines, a network perspective Juan Higareda-Almaraz, María Enríquez-Gasca, Magdalena Hernández-Ortiz, Osbaldo Resendis-Antonio, Sergio Encarnación-Guevara BMC Systems Biology 2011, 5:96 (22 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	77. 203 Accesses	Research article Critical assessment of human metabolic pathway databases: a stepping stone for future integration Miranda D Stobbe, Sander M Houten, Gerbert A Jansen, Antoine HC van Kampen, Perry D Moerland BMC Systems Biology 2011, 5:165 (14 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	78. 202 Accesses	Research article A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle Anthony C Smith, Alan J Robinson BMC Systems Biology 2011, 5:102 (29 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	79. 203 Accesses	Research article MicroRNAs coordinately regulate protein complexes Steffen Sass, Sabine Dietmann, Ulrike C Burk, Simone Brabletz, Dominik Lutter, Andreas Kowarsch, Klaus F Mayer, Thomas Brabletz, Andreas Ruepp, Fabian J Theis, Yu Wang BMC Systems Biology 2011, 5:136 (25 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	80. 203 Accesses	Research article Phenotypic heterogeneity in mycobacterial stringent response Sayantari Ghosh, Kamakshi Sureka, Bhaswar Ghosh, Indrani Bose, Joyoti Basu, Manikuntala Kundu BMC Systems Biology 2011, 5:18 (27 January 2011) Abstract \| Full text \| PDF \| PubMed
	81. 200 Accesses	Research article Impact of receptor clustering on ligand binding Bertrand R Caré, Hédi A Soula BMC Systems Biology 2011, 5:48 (31 March 2011) Abstract \| Full text \| PDF \| PubMed
	82. 200 Accesses	Research article In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae Flavio Amara, Riccardo Colombo, Paolo Cazzaniga, Dario Pescini, Attila Csikász-Nagy, Marco Muzi Falconi, Daniela Besozzi, Paolo Plevani BMC Systems Biology 2013, 7:24 (20 March 2013) Abstract \| Provisional PDF \| PubMed
	83. 200 Accesses	Database SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks Dávid Fazekas, Mihály Koltai, Dénes Türei, Dezső Módos, Máté Pálfy, Zoltán Dúl, Lilian Zsákai, Máté Szalay-Bekő, Katalin Lenti, Illés J Farkas, Tibor Vellai, Péter Csermely, Tamás Korcsmáros BMC Systems Biology 2013, 7:7 (18 January 2013) Abstract \| Full text \| PDF \| PubMed
	84. 198 Accesses	Methodology article From correlation to causation networks: a simple approximate learning algorithm and its application to high-dimensional plant gene expression data Rainer Opgen-Rhein, Korbinian Strimmer BMC Systems Biology 2007, 1:37 (6 August 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	85. 198 Accesses	Methodology article A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data Min Li, Hanhui Zhang, Jian-xin Wang, Yi Pan BMC Systems Biology 2012, 6:15 (10 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	86. 197 Accesses	Research article Identification of functional modules using network topology and high-throughput data Igor Ulitsky, Ron Shamir BMC Systems Biology 2007, 1:8 (26 January 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Connected subnetworks of functionally related proteins are discovered by a novel computational technique integrating analysis of topological properties of gene and protein networks and information obtained from high-throughput experiments.
	87. 195 Accesses	Software The Systems Biology Research Tool: evolvable open-source software Jeremiah Wright, Andreas Wagner BMC Systems Biology 2008, 2:55 (29 June 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	88. 194 Accesses	Methodology article Novel semantic similarity measure improves an integrative approach to predicting gene functional associations Fatemeh Vafaee, Daniela Rosu, Fiona Broackes-Carter, Igor Jurisica BMC Systems Biology 2013, 7:22 (14 March 2013) Abstract \| Full text \| PDF \| PubMed
	89. 193 Accesses	Methodology article Efficient characterization of high-dimensional parameter spaces for systems biology Elías Zamora-Sillero, Marc Hafner, Ariane Ibig, Joerg Stelling, Andreas Wagner BMC Systems Biology 2011, 5:142 (15 September 2011) Abstract \| Full text \| PDF \| PubMed
	90. 193 Accesses	Methodology article Integrating external biological knowledge in the construction of regulatory networks from time-series expression data Kenneth Lo, Adrian E Raftery, Kenneth M Dombek, Jun Zhu, Eric E Schadt, Roger E Bumgarner, Ka Yeung BMC Systems Biology 2012, 6:101 (16 August 2012) Abstract \| Full text \| PDF \| PubMed
	91. 193 Accesses	Methodology article TIGRESS: Trustful Inference of Gene REgulation using Stability Selection Anne-Claire Haury, Fantine Mordelet, Paola Vera-Licona, Jean-Philippe Vert BMC Systems Biology 2012, 6:145 (22 November 2012) Abstract \| Full text \| PDF \| PubMed
	92. 191 Accesses	Research article Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials Luis Caspeta, Saeed Shoaie, Rasmus Agren, Intawat Nookaew, Jens Nielsen BMC Systems Biology 2012, 6:24 (4 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new genome-scale metabolic model of the industrially important yeast species Pichia stipitis and Pichia pastoris enables the modeling of growth on xylose, which is essential to optimising the production of ethanol from biomass.
	93. 192 Accesses	Research article A Novel microRNA and transcription factor mediated regulatory network in schizophrenia An-Yuan Guo, Jingchun Sun, Peilin Jia, Zhongming Zhao BMC Systems Biology 2010, 4:10 (15 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	94. 192 Accesses	Methodology article Prediction of novel synthetic pathways for the production of desired chemicals Ayoun Cho, Hongseok Yun, Jin Park, Sang Lee, Sunwon Park BMC Systems Biology 2010, 4:35 (28 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	95. 192 Accesses	Research article The evolution of metabolic networks of E. coli David J Baumler, Roman G Peplinski, Jennifer L Reed, Jeremy D Glasner, Nicole T Perna BMC Systems Biology 2011, 5:182 (1 November 2011) Abstract \| Full text \| PDF \| PubMed
	96. 188 Accesses	Research article Similar temperature dependencies of glycolytic enzymes: an evolutionary adaptation to temperature dynamics? Luisa Ana B Cruz, Marit Hebly, Giang-Huong Duong, Sebastian A Wahl, Jack T Pronk, Joseph J Heijnen, Pascale Daran-Lapujade, Walter M van Gulik BMC Systems Biology 2012, 6:151 (7 December 2012) Abstract \| Full text \| PDF \| PubMed
	97. 187 Accesses	Research article Computational modeling of apoptotic signaling pathways induced by cisplatin Ji-Young Hong, Geun-Hong Kim, Jun-Woo Kim, Soon-Sung Kwon, Eisuke F Sato, Kwang-Hyun Cho, Eun Shim BMC Systems Biology 2012, 6:122 (11 September 2012) Abstract \| Full text \| PDF \| PubMed
	98. 186 Accesses	Research article A reconfigurable NAND/NOR genetic logic gate Angel Goñi-Moreno, Martyn Amos BMC Systems Biology 2012, 6:126 (18 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel genetic circuit is proposed and computationally tested that can be dynamically reconfigured to serve as either a NAND or NOR genetic logic gate in either single cells or cell populations.
	99. 188 Accesses	Research article Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo Jesse J Smith, Renée Kenney, David J Gagne, Brian P Frushour, William Ladd, Heidi L Galonek, Kristine Israelian, Jeffrey Song, Giedre Razvadauskaite, Amy V Lynch, David P Carney, Robin J Johnson, Siva Lavu, Andre Iffland, Peter J Elliott, Philip D Lambert, Keith O Elliston, Michael R Jirousek, Jill C Milne, Olivier Boss BMC Systems Biology 2009, 3:31 (10 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	100. 184 Accesses	Research article Genetic and environmental pathways to complex diseases Julia M Gohlke, Reuben Thomas, Yonqing Zhang, Michael C Rosenstein, Allan P Davis, Cynthia Murphy, Kevin G Becker, Carolyn J Mattingly, Christopher J Portier BMC Systems Biology 2009, 3:46 (5 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central