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	51. 2559 Accesses	Research article A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation Mark T Mc Auley, Darren J Wilkinson, Janette JL Jones, Thomas BL Kirkwood BMC Systems Biology 2012, 6:130 (10 October 2012) Abstract \| Full text \| PDF \| PubMed
	52. 2516 Accesses	Research article The evolution of metabolic networks of E. coli David J Baumler, Roman G Peplinski, Jennifer L Reed, Jeremy D Glasner, Nicole T Perna BMC Systems Biology 2011, 5:182 (1 November 2011) Abstract \| Full text \| PDF \| PubMed
	53. 2509 Accesses	Research article The genetic control of growth rate: a systems biology study in yeast Pınar Pir, Alex Gutteridge, Jian Wu, Bharat Rash, Douglas B Kell, Nianshu Zhang, Stephen G Oliver BMC Systems Biology 2012, 6:4 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	54. 2504 Accesses	Methodology article A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue Walter K Schlage, Jurjen W Westra, Stephan Gebel, Natalie L Catlett, Carole Mathis, Brian P Frushour, Arnd Hengstermann, Aaron Van Hooser, Carine Poussin, Ben Wong, Michael Lietz, Jennifer Park, David Drubin, Emilija Veljkovic, Manuel C Peitsch, Julia Hoeng, Renee Deehan BMC Systems Biology 2011, 5:168 (19 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	55. 2499 Accesses	Research article Proteomic patterns of cervical cancer cell lines, a network perspective Juan Higareda-Almaraz, María Enríquez-Gasca, Magdalena Hernández-Ortiz, Osbaldo Resendis-Antonio, Sergio Encarnación-Guevara BMC Systems Biology 2011, 5:96 (22 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	56. 2489 Accesses	Research article targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis Karthik Raman, Kalidas Yeturu, Nagasuma Chandra BMC Systems Biology 2008, 2:109 (19 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	57. 2473 Accesses	Methodology article Stochastic Boolean networks: An efficient approach to modeling gene regulatory networks Jinghang Liang, Jie Han BMC Systems Biology 2012, 6:113 (28 August 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment
	58. 2463 Accesses	Research article Combinatorial network of transcriptional regulation and microRNA regulation in human cancer Hui Yu, Kang Tu, Yi-Jie Wang, Jun-Zhe Mao, Lu Xie, Yuan-Yuan Li, Yi-Xue Li BMC Systems Biology 2012, 6:61 (12 June 2012) Abstract \| Full text \| PDF \| PubMed
	59. 2419 Accesses	Methodology article From correlation to causation networks: a simple approximate learning algorithm and its application to high-dimensional plant gene expression data Rainer Opgen-Rhein, Korbinian Strimmer BMC Systems Biology 2007, 1:37 (6 August 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	60. 2399 Accesses	Software VANTED v2: a framework for systems biology applications Hendrik Rohn, Astrid Junker, Anja Hartmann, Eva Grafahrend-Belau, Hendrik Treutler, Matthias Klapperstück, Tobias Czauderna, Christian Klukas, Falk Schreiber BMC Systems Biology 2012, 6:139 (10 November 2012) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Cited on BioMed Central
	61. 2391 Accesses	Research article Statistical methods on detecting differentially expressed genes for RNA-seq data Zhongxue Chen, Jianzhong Liu, Hon Ng, Saralees Nadarajah, Howard L Kaufman, Jack Y Yang, Youping Deng BMC Systems Biology 2011, 5(Suppl 3):S1 (23 December 2011) Abstract \| Full text \| PDF
	62. 2387 Accesses	Research article A metabolite-centric view on flux distributions in genome-scale metabolic models S Riemer, René Rex, Dietmar Schomburg BMC Systems Biology 2013, 7:33 (12 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	63. 2354 Accesses	Research article Gene interaction enrichment and network analysis to identify dysregulated pathways and their interactions in complex diseases Yu Liu, Mehmet Koyutürk, Jill S Barnholtz-Sloan, Mark R Chance BMC Systems Biology 2012, 6:65 (13 June 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	64. 2332 Accesses	Methodology article Rule-based multi-level modeling of cell biological systems Carsten Maus, Stefan Rybacki, Adelinde M Uhrmacher BMC Systems Biology 2011, 5:166 (17 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary ML-Rules is a formal modeling language for implementing rule-based modeling of biochemical systems at multiple levels with bidirectional causation between them, simplifying construction of hierarchical multi-level models for general users.
	65. 2328 Accesses	Research article The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape Sylvain Tollis, Anna E Dart, George Tzircotis, Robert G Endres BMC Systems Biology 2010, 4:149 (8 November 2010) Abstract \| Full text \| PDF \| PubMed
	66. 2317 Accesses	Research article Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis Laxman Yetukuri, Mikko Katajamaa, Gema Medina-Gomez, Tuulikki Seppänen-Laakso, Antonio Vidal-Puig, Matej Orešič BMC Systems Biology 2007, 1:12 (15 February 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	67. 2317 Accesses	Database SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks Dávid Fazekas, Mihály Koltai, Dénes Türei, Dezső Módos, Máté Pálfy, Zoltán Dúl, Lilian Zsákai, Máté Szalay-Bekő, Katalin Lenti, Illés J Farkas, Tibor Vellai, Péter Csermely, Tamás Korcsmáros BMC Systems Biology 2013, 7:7 (18 January 2013) Abstract \| Full text \| PDF \| PubMed
	68. 2297 Accesses	Research article Biochemical fluctuations, optimisation and the linear noise approximation Jürgen Pahle, Joseph D Challenger, Pedro Mendes, Alan J McKane BMC Systems Biology 2012, 6:86 (17 July 2012) Abstract \| Full text \| PDF \| PubMed
	69. 2293 Accesses	Research article A genome-scale metabolic model of the lipid-accumulating yeast Yarrowia lipolytica Nicolas Loira, Thierry Dulermo, Jean-Marc Nicaud, David Sherman BMC Systems Biology 2012, 6:35 (4 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	70. 2288 Accesses	Research article Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation Patrik Sahlin, Pontus Melke, Henrik Jönsson BMC Systems Biology 2011, 5:2 (5 January 2011) Abstract \| Full text \| PDF \| PubMed
	71. 2286 Accesses	Research article Modelling the widespread effects of TOC1 signalling on the plant circadian clock and its outputs Alexandra Pokhilko, Paloma Mas, Andrew J Millar BMC Systems Biology 2013, 7:23 (19 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	72. 2284 Accesses	Research article Systems biology of bacterial nitrogen fixation: High-throughput technology and its integrative description with constraint-based modeling Osbaldo Resendis-Antonio, Magdalena Hernández, Emmanuel Salazar, Sandra Contreras, Gabriel Batallar, Yolanda Mora, Sergio Encarnación BMC Systems Biology 2011, 5:120 (29 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	73. 2277 Accesses	Methodology article Network methods for describing sample relationships in genomic datasets: application to Huntington’s disease Michael C Oldham, Peter Langfelder, Steve Horvath BMC Systems Biology 2012, 6:63 (12 June 2012) Abstract \| Full text \| PDF \| PubMed
	74. 2274 Accesses	Research article Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells Hyunju Cho, Ming Wu, Linxia Zhang, Ryan Thompson, Aritro Nath, Christina Chan BMC Systems Biology 2013, 7:9 (22 January 2013) Abstract \| Full text \| PDF \| PubMed
	75. 2254 Accesses	Research article Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention Rainer Poltz, Michael Naumann BMC Systems Biology 2012, 6:125 (15 September 2012) Abstract \| Full text \| PDF \| PubMed