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	1. 1705 Accesses	Methodology article Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0 Michael Weber, Sebastian G Henkel, Sebastian Vlaic, Reinhard Guthke, Everardus J van Zoelen, Dominik Driesch BMC Systems Biology 2013, 7:1 (2 January 2013) Abstract \| Provisional PDF \| PubMed
	2. 1481 Accesses	Research article Time-resolved metabolomics reveals metabolic modulation in rice foliage Shigeru Sato, Masanori Arita, Tomoyoshi Soga, Takaaki Nishioka, Masaru Tomita BMC Systems Biology 2008, 2:51 (18 June 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	3. 1373 Accesses	Research article Understanding network concepts in modules Jun Dong, Steve Horvath BMC Systems Biology 2007, 1:24 (4 June 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	4. 1262 Accesses	Research article Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation Patrik Sahlin, Pontus Melke, Henrik Jönsson BMC Systems Biology 2011, 5:2 (5 January 2011) Abstract \| Full text \| PDF \| PubMed
	5. 821 Accesses	Database AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease Satoshi Mizuno, Risa Iijima, Soichi Ogishima, Masataka Kikuchi, Yukiko Matsuoka, Samik Ghosh, Tadashi Miyamoto, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka BMC Systems Biology 2012, 6:52 (30 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary AlzPathway is a publicly available database collating known Alzheimer's disease intra, inter and extra cellular signalling pathways into a comprehensive pathway map, providing a useful resource in deciphering Alzheimer's disease pathogenesis.
	6. 811 Accesses	Research article Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework Gaurav Kumar, Edmond J Breen, Shoba Ranganathan BMC Systems Biology 2013, 7:12 (6 February 2013) Abstract \| Provisional PDF \| PubMed
	7. 798 Accesses	Research article Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells Hyunju Cho, Ming Wu, Linxia Zhang, Ryan Thompson, Aritro Nath, Christina Chan BMC Systems Biology 2013, 7:9 (22 January 2013) Abstract \| Full text \| PDF \| PubMed
	8. 746 Accesses	Research article Prioritizing cancer-related genes with aberrant methylation based on a weighted protein-protein interaction network Hui Liu, Jianzhong Su, Junhua Li, Hongbo Liu, Jie Lv, Boyan Li, Hong Qiao, Yan Zhang BMC Systems Biology 2011, 5:158 (11 October 2011) Abstract \| Full text \| PDF \| PubMed
	9. 703 Accesses	Methodology article Precise generation of systems biology models from KEGG pathways Clemens Wrzodek, Finja Büchel, Manuel Ruff, Andreas Dräger, Andreas Zell BMC Systems Biology 2013, 7:15 (21 February 2013) Abstract \| Provisional PDF \| PubMed
	10. 698 Accesses	Methodology article Multilevel omic data integration in cancer cell lines: advanced annotation and emergent properties Yuanhua Liu, Valentina Devescovi, Suning Chen, Christine Nardini BMC Systems Biology 2013, 7:14 (19 February 2013) Abstract \| Provisional PDF \| PubMed
	11. 686 Accesses	Proceedings Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis Chuanli Wang, Longyun Guo, Yixue Li, Zhuo Wang BMC Systems Biology 2012, 6(Suppl 2):S9 (12 December 2012) Abstract \| Full text \| PDF \| PubMed
	12. 640 Accesses	Research article Crosstalk between transcription factors and microRNAs in human protein interaction network Chen-Ching Lin, Ya-Jen Chen, Cho-Yi Chen, Yen-Jen Oyang, Hsueh-Fen Juan, Hsuan-Cheng Huang BMC Systems Biology 2012, 6:18 (13 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	13. 631 Accesses	Research article A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis Kamil Erguler, Myrtani Pieri, Constantinos Deltas BMC Systems Biology 2013, 7:16 (21 February 2013) Abstract \| Provisional PDF \| PubMed
	14. 572 Accesses	Review A review of imaging techniques for systems biology Armen R Kherlopian, Ting Song, Qi Duan, Mathew A Neimark, Ming J Po, John K Gohagan, Andrew F Laine BMC Systems Biology 2008, 2:74 (12 August 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	15. 571 Accesses	Research article Reconstruction and analysis of genome-scale metabolic model of a photosynthetic bacterium Arnau Montagud, Emilio Navarro, Pedro Fernández de Córdoba, Javier F Urchueguía, Kiran Patil BMC Systems Biology 2010, 4:156 (17 November 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	16. 553 Accesses	Research article Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT Ulf W Liebal, Thomas Millat, Jon Marles-Wright, Richard J Lewis, Olaf Wolkenhauer BMC Systems Biology 2013, 7:3 (15 January 2013) Abstract \| Full text \| PDF \| PubMed
	17. 515 Accesses	Research article Model composition through model reduction: a combined model of CD95 and NF-kappaB signaling pathways Elena Kutumova, Andrei Zinovyev, Ruslan Sharipov, Fedor Kolpakov BMC Systems Biology 2013, 7:13 (15 February 2013) Abstract \| Provisional PDF \| PubMed
	18. 513 Accesses	Research article Low-complexity regions within protein sequences have position-dependent roles Alain Coletta, John W Pinney, David Solís, James Marsh, Steve R Pettifer, Teresa K Attwood BMC Systems Biology 2010, 4:43 (13 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	19. 507 Accesses	Methodology article Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE Yuliang Wang, James A Eddy, Nathan D Price BMC Systems Biology 2012, 6:153 (13 December 2012) Abstract \| Full text \| PDF \| PubMed
	20. 500 Accesses	Methodology article Computational codon optimization of synthetic gene for protein expression Bevan Chung, Dong-Yup Lee BMC Systems Biology 2012, 6:134 (20 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel method for codon usage optimization in artificial gene synthesis, optimizing use of both individual codon usage and codon context approaches, is predicted to lead to improved in vitro heterologous protein expression in biotechnology applications.
	21. 495 Accesses	Research article A Novel microRNA and transcription factor mediated regulatory network in schizophrenia An-Yuan Guo, Jingchun Sun, Peilin Jia, Zhongming Zhao BMC Systems Biology 2010, 4:10 (15 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	22. 491 Accesses	Research article An investigation of spatial signal transduction in cellular networks Aiman Alam-Nazki, J Krishnan BMC Systems Biology 2012, 6:83 (5 July 2012) Abstract \| Full text \| PDF \| PubMed
	23. 483 Accesses	Research article A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen Galina Lebedeva, Azusa Yamaguchi, Simon P Langdon, Kenneth Macleod, David J Harrison BMC Systems Biology 2012, 6:138 (8 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A minimal mechanistic model of estrogen receptor alpha-dependent gene expression, predicts complex non-linear effects in transcriptional response to natural hormone 17 beta-estradiol and its external competitor tamoxifen under a range of biologically plausible parameter values.
	24. 479 Accesses	Research article A reconfigurable NAND/NOR genetic logic gate Angel Goñi-Moreno, Martyn Amos BMC Systems Biology 2012, 6:126 (18 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel genetic circuit is proposed and computationally tested that can be dynamically reconfigured to serve as either a NAND or NOR genetic logic gate in either single cells or cell populations.
	25. 465 Accesses	Research article Genome-scale reconstruction and system level investigation of the metabolic network of Methylobacterium extorquens AM1 Rémi Peyraud, Kathrin Schneider, Patrick Kiefer, Stéphane Massou, Julia A Vorholt, Jean-Charles Portais BMC Systems Biology 2011, 5:189 (10 November 2011) Abstract \| Full text \| PDF \| PubMed