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	1. 1831 Accesses	Methodology article Prediction of novel synthetic pathways for the production of desired chemicals Ayoun Cho, Hongseok Yun, Jin Park, Sang Lee, Sunwon Park BMC Systems Biology 2010, 4:35 (28 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	2. 1458 Accesses	Research article Spice: discovery of phenotype-determining component interplays Zhengzhang Chen, Kanchana Padmanabhan, Andrea M Rocha, Yekaterina Shpanskaya, James R Mihelcic, Kathleen Scott, Nagiza F Samatova BMC Systems Biology 2012, 6:40 (14 May 2012) Abstract \| Full text \| PDF \| PubMed
	3. 1158 Accesses	Research article Constraint-based modeling analysis of the metabolism of two Pelobacter species Jun Sun, Shelley A Haveman, Olivia Bui, Tom R Fahland, Derek R Lovley BMC Systems Biology 2010, 4:174 (23 December 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	4. 976 Accesses	Research article An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules Huaxia Qin, Michael WY Chan, Sandya Liyanarachchi, Curtis Balch, Dustin Potter, Irene J Souriraj, Alfred SL Cheng, Francisco J Agosto-Perez, Elena V Nikonova, Pearlly S Yan, Huey-Jen Lin, Kenneth P Nephew, Joel H Saltz, Louise C Showe, Tim HM Huang, Ramana V Davuluri BMC Systems Biology 2009, 3:73 (17 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	5. 938 Accesses	Software An online model composition tool for system biology models Sarp A Coskun, A Ercument Cicek, Nicola Lai, Ranjan K Dash, Z Meral Ozsoyoglu, Gultekin Ozsoyoglu BMC Systems Biology 2013, 7:88 (5 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	6. 934 Accesses	Research article The smallest chemical reaction system with bistability Thomas Wilhelm BMC Systems Biology 2009, 3:90 (8 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary The smallest bistable system contains just two reactants and four irreversible reactions, and it reveals that the necessary conditions for bistability are positive feedback, filtering out small stimuli, and a mechanism to prevent 'explosion' of the system.
	7. 846 Accesses	Software COBRApy: COnstraints-Based Reconstruction and Analysis for Python Ali Ebrahim, Joshua A Lerman, Bernhard O Palsson, Daniel R Hyduke BMC Systems Biology 2013, 7:74 (8 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	8. 821 Accesses	Research article The genetic control of growth rate: a systems biology study in yeast Pınar Pir, Alex Gutteridge, Jian Wu, Bharat Rash, Douglas B Kell, Nianshu Zhang, Stephen G Oliver BMC Systems Biology 2012, 6:4 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000
	9. 783 Accesses	Research article Genomic clustering and co-regulation of transcriptional networks in the pathogenic fungus Fusarium graminearum Katherine Lawler, Kim Hammond-Kosack, Alvis Brazma, Richard MR Coulson BMC Systems Biology 2013, 7:52 (27 June 2013) Abstract \| Full text \| PDF \| PubMed
	10. 718 Accesses	Methodology article The systems biology simulation core algorithm Roland Keller, Alexander Dörr, Akito Tabira, Akira Funahashi, Michael J Ziller, Richard Adams, Nicolas Rodriguez, Nicolas Novère, Noriko Hiroi, Hannes Planatscher, Andreas Zell, Andreas Dräger BMC Systems Biology 2013, 7:55 (5 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	11. 716 Accesses	Research article Rule–based regulatory and metabolic model for Quorum sensing in P. aeruginosa Nadine S Schaadt, Anke Steinbach, Rolf W Hartmann, Volkhard Helms BMC Systems Biology 2013, 7:81 (21 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	12. 716 Accesses	Research article Genome-scale reconstruction of metabolic network for a halophilic extremophile, Chromohalobacter salexigens DSM 3043 Özlem Ates, Ebru Oner, Kazim Y Arga BMC Systems Biology 2011, 5:12 (21 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	13. 703 Accesses	Research article Post-translational regulation enables robust p53 regulation Yong-Jun Shin, Kai-Yuan Chen, Ali H Sayed, Brandon Hencey, Xiling Shen BMC Systems Biology 2013, 7:83 (30 August 2013) Abstract \| Full text \| PDF \| PubMed
	14. 703 Accesses	Review Topology of molecular interaction networks Wynand Winterbach, Piet Van Mieghem, Marcel Reinders, Huijuan Wang, Dick de Ridder BMC Systems Biology 2013, 7:90 (16 September 2013) Abstract \| Provisional PDF \| PubMed
	15. 694 Accesses	Methodology article A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells Zheng Li, Shireesh Srivastava, Xuerui Yang, Sheenu Mittal, Paul Norton, James Resau, Brian Haab, Christina Chan BMC Systems Biology 2007, 1:21 (11 May 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	16. 692 Accesses	Research article Crosstalk between transcription factors and microRNAs in human protein interaction network Chen-Ching Lin, Ya-Jen Chen, Cho-Yi Chen, Yen-Jen Oyang, Hsueh-Fen Juan, Hsuan-Cheng Huang BMC Systems Biology 2012, 6:18 (13 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	17. 650 Accesses	Research article Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25 Asfar S Azmi, Aliccia Bollig-Fischer, Bin Bao, Bum-Joon Park, Sun-Hye Lee, Gyu Yong-Song, Gregory Dyson, Chandan K Reddy, Fazlul H Sarkar, Ramzi M Mohammad BMC Systems Biology 2013, 7:85 (3 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	18. 639 Accesses	Research article Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study Yu-Chao Wang, Che Lin, Ming-Ta Chuang, Wen-Ping Hsieh, Chung-Yu Lan, Yung-Jen Chuang, Bor-Sen Chen BMC Systems Biology 2013, 7:79 (16 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	19. 633 Accesses	Research article Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate Marta N Bogdał, Beata Hat, Marek Kochańczyk, Tomasz Lipniacki BMC Systems Biology 2013, 7:67 (24 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	20. 640 Accesses	Research article Identification of upstream regulators for prognostic expression signature genes in colorectal cancer Taejeong Bae, Kyoohyoung Rho, Jin Woo Choi, Katsuhisa Horimoto, Wankyu Kim, Sunghoon Kim BMC Systems Biology 2013, 7:86 (4 September 2013) Abstract \| Full text \| PDF \| PubMed
	21. 629 Accesses	Methodology article Simultaneous model discrimination and parameter estimation in dynamic models of cellular systems Maria Rodriguez-Fernandez, Markus Rehberg, Andreas Kremling, Julio R Banga BMC Systems Biology 2013, 7:76 (12 August 2013) Abstract \| Full text \| PDF \| PubMed
	22. 628 Accesses	Research article Bridging the gap between gene expression and metabolic phenotype via kinetic models Francisco G Vital-Lopez, Anders Wallqvist, Jaques Reifman BMC Systems Biology 2013, 7:63 (22 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	23. 623 Accesses	Research article In silico feasibility of novel biodegradation pathways for 1,2,4-trichlorobenzene Stacey D Finley, Linda J Broadbelt, Vassily Hatzimanikatis BMC Systems Biology 2010, 4:7 (2 February 2010) Abstract \| Full text \| PDF \| PubMed
	24. 621 Accesses	Research article Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder Ruoting Yang, Bernie J Daigle Jr, Seid Y Muhie, Rasha Hammamieh, Marti Jett, Linda Petzold, Francis J Doyle BMC Systems Biology 2013, 7:80 (20 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	25. 606 Accesses	Research article Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design Brett A Boghigian, Hai Shi, Kyongbum Lee, Blaine A Pfeifer BMC Systems Biology 2010, 4:49 (23 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central