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Volume 4 (2010) - May 2010

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Research article   Open Access

Co-expression module analysis reveals biological processes, genomic gain, and regulatory mechanisms associated with breast cancer progression

Zhiao Shi, Catherine K Derow, Bing Zhang BMC Systems Biology 2010, 4:74 (27 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Individual fates of mesenchymal stem cells in vitro

Axel Krinner, Martin Hoffmann, Markus Loeffler, Dirk Drasdo, Joerg Galle BMC Systems Biology 2010, 4:73 (27 May 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

An information-flow-based model with dissipation, saturation and direction for active pathway inference

Xianwen Ren, Xiaobo Zhou, Ling-Yun Wu, Xiang-Sun Zhang BMC Systems Biology 2010, 4:72 (27 May 2010)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access

Mathematical modeling of translation initiation for the estimation of its efficiency to computationally design mRNA sequences with desired expression levels in prokaryotes

Dokyun Na, Sunjae Lee, Doheon Lee BMC Systems Biology 2010, 4:71 (26 May 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Inferring the physical connectivity of complex networks from their functional dynamics

Hung Ta, Chang Yoon, Liisa Holm, Seung Han BMC Systems Biology 2010, 4:70 (26 May 2010)

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Methodology article   Open Access

Set-base dynamical parameter estimation and model invalidation for biochemical reaction networks

Philipp Rumschinski, Steffen Borchers, Sandro Bosio, Robert Weismantel, Rolf Findeisen BMC Systems Biology 2010, 4:69 (25 May 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Reconstruction of the yeast protein-protein interaction network involved in nutrient sensing and global metabolic regulation

Subir K Nandy, Paula Jouhten, Jens Nielsen BMC Systems Biology 2010, 4:68 (25 May 2010)

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Research article   Open Access Highly Accessed

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

Raj Chari, Bradley P Coe, Emily A Vucic, William W Lockwood, Wan L Lam BMC Systems Biology 2010, 4:67 (17 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Avoiding transcription factor competition at promoter level increases the chances of obtaining oscillation

Andreea Munteanu, Marco Constante, Mark Isalan, Ricard V Solé BMC Systems Biology 2010, 4:66 (17 May 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The mEPN scheme: an intuitive and flexible graphical system for rendering biological pathways

Tom C Freeman, Sobia Raza, Athanasios Theocharidis, Peter Ghazal BMC Systems Biology 2010, 4:65 (17 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive systems analysis

Marc T Facciotti, Wyming L Pang, Fang-yin Lo, Kenia Whitehead, Tie Koide, Ken-ichi Masumura, Min Pan, Amardeep Kaur, David J Larsen, David J Reiss, Linh Hoang, Ewa Kalisiak, Trent Northen, Sunia A Trauger, Gary Siuzdak, Nitin S Baliga BMC Systems Biology 2010, 4:64 (14 May 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Construction of a large scale integrated map of macrophage pathogen recognition and effector systems

Sobia Raza, Neil McDerment, Paul A Lacaze, Kevin Robertson, Steven Watterson, Ying Chen, Michael Chisholm, George Eleftheriadis, Stephanie Monk, Maire O'Sullivan, Arran Turnbull, Douglas Roy, Athanasios Theocharidis, Peter Ghazal, Tom C Freeman BMC Systems Biology 2010, 4:63 (14 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Correlation Network Analysis reveals a sequential reorganization of metabolic and transcriptional states during germination and gene-metabolite relationships in developing seedlings of Arabidopsis

Elizabeth Allen, Annick Moing, Timothy MD Ebbels, Mickaël Maucourt, A Deri Tomos, Dominique Rolin, Mark A Hooks BMC Systems Biology 2010, 4:62 (13 May 2010)

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Research article   Open Access

Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling

Joachim B Ritter, Aljoscha S Wahl, Susann Freund, Yvonne Genzel, Udo Reichl BMC Systems Biology 2010, 4:61 (13 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

Francisco Azuaje, Yvan Devaux, Daniel R Wagner BMC Systems Biology 2010, 4:60 (12 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Evolution of metabolic network organization

Aurélien Mazurie, Danail Bonchev, Benno Schwikowski, Gregory A Buck BMC Systems Biology 2010, 4:59 (11 May 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited

Alexei Vazquez, Jiangxia Liu, Yi Zhou, Zoltán N Oltvai BMC Systems Biology 2010, 4:58 (6 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

Research article   Open Access

Spatio-temporal modeling of signaling protein recruitment to EGFR

Ming-yu Hsieh, Shujie Yang, Mary Raymond-Stinz, Jeremy S Edwards, Bridget S Wilson BMC Systems Biology 2010, 4:57 (6 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Identifying essential genes in bacterial metabolic networks with machine learning methods

Kitiporn Plaimas, Roland Eils, Rainer König BMC Systems Biology 2010, 4:56 (3 May 2010)

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