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BMC Systems Biology, Volume 3

 
Software
DASMiner: discovering and integrating data from DAS sources
Diogo F T Veiga, Helena F Deus, Caner Akdemir, Ana Tereza R Vasconcelos, Jonas S Almeida
BMC Systems Biology 2009, 3:109 (17November2009)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Research article
Network analysis of the transcriptional pattern of young and old cells of Escherichia coli during lag phase
Carmen Pin, Matthew D Rolfe, Marina Muoz-Cuevas, Jay CD Hinton, Michael W Peck, Nicholas J Walton, Jzsef Baranyi
BMC Systems Biology 2009, 3:108 (16November2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Long-term prediction of fish growth under varying ambient temperatures using a multiscale dynamic model
Nadav S Bar, Nicole Radde
BMC Systems Biology 2009, 3:107 (10November2009)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Methodology article
Using the ratio of means as the effect size measure in combining results of microarray experiments
Pingzhao Hu, Celia MT Greenwood, Joseph Beyene
BMC Systems Biology 2009, 3:106 (5November2009)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Research article
A model invalidation-based approach for elucidating biological signalling pathways, applied to the chemotaxis pathway in R. sphaeroides
Mark AJ Roberts, Elias August, Abdullah Hamadeh, Philip K Maini, Patrick E McSharry, Judith P Armitage, Antonis Papachristodoulou
BMC Systems Biology 2009, 3:105 (31October2009)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Research article
13C-metabolic flux ratio and novel carbon path analyses confirmed that Trichoderma reesei uses primarily the respirative pathway also on the preferred carbon source glucose
Paula Jouhten, Esa Pitknen, Tiina Pakula, Markku Saloheimo, Merja Penttil, Hannu Maaheimo
BMC Systems Biology 2009, 3:104 (29October2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
Inferring branching pathways in genome-scale metabolic networks
Esa Pitkanen, Paula Jouhten, Juho Rousu
BMC Systems Biology 2009, 3:103 (29October2009)
[Abstract] [Provisional PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Research article
How to identify essential genes from molecular networks?
Gabriel del Rio, Dirk Koschtzki, Gerardo Coello
BMC Systems Biology 2009, 3:102 (13October2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments
Ramon Grima
BMC Systems Biology 2009, 3:101 (8October2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway
Richard J Orton, Michiel E Adriaens, Amelie Gormand, Oliver E Sturm, Walter Kolch, David R Gilbert
BMC Systems Biology 2009, 3:100 (5October2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Software
An editor for pathway drawing and data visualization in the Biopathways Workbench
Robert W Byrnes, Dawn Cotter, Andreia Maer, Joshua Li, David Nadeau, Shankar Subramaniam
BMC Systems Biology 2009, 3:99 (2October2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling
Dominik M Wittmann, Jan Krumsiek, Julio Saez-Rodriguez, Douglas A Lauffenburger, Steffen Klamt, Fabian J Theis
BMC Systems Biology 2009, 3:98 (28September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection
Nicole Philippi, Dorothee Walter, Rebekka Schlatter, Karine Ferreira, Michael Ederer, Oliver Sawodny, Jens Timmer, Christoph Borner, Thomas Dandekar
BMC Systems Biology 2009, 3:97 (22September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
The capacity for multistability in small gene regulatory networks
Dan Siegal-Gaskins, Erich Grotewold, Gregory D Smith
BMC Systems Biology 2009, 3:96 (21September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
A method for determining the robustness of bio-molecular oscillator models
Reza Ghaemi, Jing Sun, Pablo A Iglesias, Domitilla Del Vecchio
BMC Systems Biology 2009, 3:95 (21September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Inferring Drosophila gap gene regulatory network: a parameter sensitivity and perturbation analysis
Yves Fomekong-Nanfack, Marten Postma, Jaap A Kaandorp
BMC Systems Biology 2009, 3:94 (21September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Dissecting the fission yeast regulatory network reveals phase-specific control elements of its cell cycle
Pierre R Bushel, Nicholas A Heard, Roee Gutman, Liwen Liu, Shyamal D Peddada, Saumyadipta Pyne
BMC Systems Biology 2009, 3:93 (16September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis
Xin Fang, Anders Wallqvist, Jaques Reifman
BMC Systems Biology 2009, 3:92 (15September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis
Jacob D Feala, Laurence Coquin, Dan Zhou, Gabriel G Haddad, Giovanni Paternostro, Andrew D McCulloch
BMC Systems Biology 2009, 3:91 (9September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
The smallest chemical reaction system with bistability
Thomas Wilhelm
BMC Systems Biology 2009, 3:90 (8September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Hybrid stochastic simplifications for multiscale gene networks
Alina Crudu, Arnaud Debussche, Ovidiu Radulescu
BMC Systems Biology 2009, 3:89 (7September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
The crosstalk between EGF, IGF, and Insulin cell signaling pathways - computational and experimental analysis
Rafal Zielinski, Pawel F Przytycki, Jie Zheng, David Zhang, Teresa M Przytycka, Jacek Capala
BMC Systems Biology 2009, 3:88 (4September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
The genotype-phenotype relationship in multicellular pattern-generating models - the neglected role of pattern descriptors
Harald Martens, Siren R Veflingstad, Erik Plahte, Magni Martens, Dominique Bertrand, Stig W Omholt
BMC Systems Biology 2009, 3:87 (4September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Large-scale analysis of Arabidopsis transcription reveals a basal co-regulation network
Osnat Atias, Benny Chor, Daniel A Chamovitz
BMC Systems Biology 2009, 3:86 (3September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
From gene expression to gene regulatory networks in Arabidopsis thaliana
Chris J Needham, Iain W Manfield, Andrew J Bulpitt, Philip M Gilmartin, David R Westhead
BMC Systems Biology 2009, 3:85 (3September2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Specialized or flexible feed-forward loop motifs: a question of topology
Javier Maca, Stefanie Widder, Ricard Sol
BMC Systems Biology 2009, 3:84 (31August2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Monte Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network
Clemens Khn, Christoph Wierling, Alexander Khn, Edda Klipp, Georgia Panopoulou, Hans Lehrach, Albert J Poustka
BMC Systems Biology 2009, 3:83 (23August2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Software
Visualizing post genomics data-sets on customized pathway maps by ProMeTra aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example
Heiko Neuweger, Marcus Persicke, Stefan P Albaum, Thomas Bekel, Michael Dondrup, Andrea T Hser, Jrn Winnebald, Jessica Schneider, Jrn Kalinowski, Alexander Goesmann
BMC Systems Biology 2009, 3:82 (23August2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Optimal drug combinations and minimal hitting sets
Alexei Vazquez
BMC Systems Biology 2009, 3:81 (6August2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Knowledge based identification of essential signaling from genome-scale siRNA experiments
Armand Bankhead III, Iliana Sach, Chester Ni, Nolwenn LeMeur, Mark Kruger, Marc Ferrer, Robert Gentleman, Carol Rohl
BMC Systems Biology 2009, 3:80 (5August2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
A possibilistic framework for constraint-based metabolic flux analysis
Francisco Llaneras, Antonio Sala, Jess Pic
BMC Systems Biology 2009, 3:79 (31July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
A dynamic network of transcription in LPS-treated human subjects
Junhee Seok, Wenzhong Xiao, Lyle L Moldawer, Ronald W Davis, Markus W Covert
BMC Systems Biology 2009, 3:78 (28July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Adapted Boolean network models for extracellular matrix formation
Johannes Wollbold, Ren Huber, Dirk Pohlers, Dirk Koczan, Reinhard Guthke, Raimund W Kinne, Ulrike Gausmann
BMC Systems Biology 2009, 3:77 (21July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Hierarchical coordination of periodic genes in the cell cycle of Saccharomyces cerevisiae
Frank Emmert-Streib, Matthias Dehmer
BMC Systems Biology 2009, 3:76 (20July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Hypothesis
Calculation of the relative metastabilities of proteins in subcellular compartments of Saccharomyces cerevisiae
Jeffrey M Dick
BMC Systems Biology 2009, 3:75 (18July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditions
Roland A Pache, M Madan Babu, Patrick Aloy
BMC Systems Biology 2009, 3:74 (18July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules
Huaxia Qin, Michael WY Chan, Sandya Liyanarachchi, Curtis Balch, Dustin Potter, Irene J Souriraj, Alfred SL Cheng, Francisco J Agosto-Perez, Elena V Nikonova, Pearlly S Yan, Huey-Jen Lin, Kenneth P Nephew, Joel H Saltz, Louise C Showe, Tim HM Huang, Ramana V Davuluri
BMC Systems Biology 2009, 3:73 (17July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Cascading signaling pathways improve the fidelity of a stochastically and deterministically simulated molecular RS latch
Evan Mills, Kevin Truong
BMC Systems Biology 2009, 3:72 (17July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Mechanism of PP2A-mediated IKK dephosphorylation: a systems biological approach
Johannes Witt, Sandra Barisic, Eva Schumann, Frank Allgwer, Oliver Sawodny, Thomas Sauter, Dagmar Kulms
BMC Systems Biology 2009, 3:71 (16July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae
Thomas Williamson, Jean-Marc Schwartz, Douglas B Kell, Lubomira Stateva
BMC Systems Biology 2009, 3:70 (16July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell
Antonio Marco, Ignacio Marn
BMC Systems Biology 2009, 3:69 (15July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Computing phenomenologic Adair-Klotz constants from microscopic MWC parameters
Melanie I Stefan, Stuart J Edelstein, Nicolas Le Novre
BMC Systems Biology 2009, 3:68 (14July2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
BowTieBuilder: modeling signal transduction pathways
Jochen Supper, Luca Spangenberg, Hannes Planatscher, Andreas Drger, Adrian Schrder, Andreas Zell
BMC Systems Biology 2009, 3:67 (30June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
A systematic design method for robust synthetic biology to satisfy design specifications
Bor-Sen Chen, Chih-Hung Wu
BMC Systems Biology 2009, 3:66 (30June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Clustered microRNAs' coordination in regulating protein-protein interaction network
Xiongying Yuan, Changning Liu, Pengcheng Yang, Shunmin He, Qi Liao, Shuli Kang, Yi Zhao
BMC Systems Biology 2009, 3:65 (26June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Stochastic simulation and analysis of biomolecular reaction networks
John M Frazier, Yaroslav Chushak, Brent Foy
BMC Systems Biology 2009, 3:64 (17June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
The Symbiosis Interactome: a computational approach reveals novel components, functional interactions and modules in Sinorhizobium meliloti
Ignacio Rodriguez-Llorente, Miguel A Caviedes, Mohammed Dary, Antonio J Palomares, Francisco M Cnovas, Jos M Peregrn-Alvarez
BMC Systems Biology 2009, 3:63 (16June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Serial evolutionary networks of within-patient HIV-1 sequences reveal patterns of evolution of X4 strains
Patricia Buendia, Giri Narasimhan
BMC Systems Biology 2009, 3:62 (16June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Intervention in gene regulatory networks via greedy control policies based on long-run behavior
Xiaoning Qian, Ivan Ivanov, Noushin Ghaffari, Edward R Dougherty
BMC Systems Biology 2009, 3:61 (15June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
The mathematics of tanning
Josef Thingnes, Leiv yehaug, Eivind Hovig, Stig W Omholt
BMC Systems Biology 2009, 3:60 (9June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
A system biology approach highlights a hormonal enhancer effect on regulation of genes in a nitrate responsive "biomodule"
Damion Nero, Gabriel Krouk, Daniel Tranchina, Gloria M Coruzzi
BMC Systems Biology 2009, 3:59 (6June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [1 comment]

Software
ChemChains: a platform for simulation and analysis of biochemical networks aimed to laboratory scientists
Tom Helikar, Jim A Rogers
BMC Systems Biology 2009, 3:58 (6June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Database
LeishCyc: a biochemical pathways database for Leishmania major
Maria A Doyle, James I MacRae, David P De Souza, Eleanor C Saunders, Malcolm J McConville, Vladimir A Liki
BMC Systems Biology 2009, 3:57 (5June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Commentary
Computational disease modeling fact or fiction?
Jesper N Tegnr, Albert Compte, Charles Auffray, Gary An, Gunnar Cedersund, Gilles Clermont, Boris Gutkin, Zoltn N Oltvai, Klaas Enno Stephan, Randy Thomas, Pablo Villoslada
BMC Systems Biology 2009, 3:56 (4June2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphism
Jen-hwa Chu, Scott T Weiss, Vincent J Carey, Benjamin A Raby
BMC Systems Biology 2009, 3:55 (27May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Inference of gene pathways using mixture Bayesian networks
Younhee Ko, ChengXiang Zhai, Sandra Rodriguez-Zas
BMC Systems Biology 2009, 3:54 (19May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
An approach to evaluate the topological significance of motifs and other patterns in regulatory networks
Bjrn Goemann, Edgar Wingender, Anatolij P Potapov
BMC Systems Biology 2009, 3:53 (19May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi
Seth B Roberts, Jennifer L Robichaux, Arvind K Chavali, Patricio A Manque, Vladimir Lee, Ana M Lara, Jason A Papin, Gregory A Buck
BMC Systems Biology 2009, 3:52 (16May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems
Lan K Nguyen, Don Kulasiri
BMC Systems Biology 2009, 3:51 (11May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Systematic identifiability testing for unambiguous mechanistic modeling application to JAK-STAT, MAP kinase, and NF-B signaling pathway models
Tom Quaiser, Martin Mnnigmann
BMC Systems Biology 2009, 3:50 (9May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Comparative analysis of module-based versus direct methods for reverse-engineering transcriptional regulatory networks
Tom Michoel, Riet De Smet, Anagha Joshi, Yves Van de Peer, Kathleen Marchal
BMC Systems Biology 2009, 3:49 (7May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Information flow during gene activation by signaling molecules: ethylene transduction in Arabidopsis cells as a study system
Jos Daz, Elena R Alvarez-Buylla
BMC Systems Biology 2009, 3:48 (5May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Identification of neutral biochemical network models from time series data
Marco Vilela, Susana Vinga, Marco A Grivet Mattoso Maia, Eberhard O Voit, Jonas S Almeida
BMC Systems Biology 2009, 3:47 (5May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Genetic and environmental pathways to complex diseases
Julia M Gohlke, Reuben Thomas, Yonqing Zhang, Michael C Rosenstein, Allan P Davis, Cynthia Murphy, Kevin G Becker, Carolyn J Mattingly, Christopher J Portier
BMC Systems Biology 2009, 3:46 (5May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
miRNA-regulated dynamics in circadian oscillator models
Amitabha Nandi, Candida Vaz, Alok Bhattacharya, Ramakrishna Ramaswamy
BMC Systems Biology 2009, 3:45 (5May2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes
Neema Jamshidi, Bernhard O Palsson
BMC Systems Biology 2009, 3:44 (30April2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
A combinatorial approach to determine the context-dependent role in transcriptional and posttranscriptional regulation in Arabidopsis thaliana
Le Lu, Jinming Li
BMC Systems Biology 2009, 3:43 (28April2009)
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Research article
Simulation-based model checking approach to cell fate specification during Caenorhabditis elegans vulval development by hybrid functional Petri net with extension
Chen Li, Masao Nagasaki, Kazuko Ueno, Satoru Miyano
BMC Systems Biology 2009, 3:42 (27April2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
Recursive regularization for inferring gene networks from time-course gene expression profiles
Teppei Shimamura, Seiya Imoto, Rui Yamaguchi, Andr Fujita, Masao Nagasaki, Satoru Miyano
BMC Systems Biology 2009, 3:41 (22April2009)
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Research article
Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway
Maria Luisa Guerriero, Anna Dudka, Nicholas Underhill-Day, John K Heath, Corrado Priami
BMC Systems Biology 2009, 3:40 (15April2009)
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Research article
Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations
Hossein Zare, Dipen Sangurdekar, Poonam Srivastava, Mostafa Kaveh, Arkady Khodursky
BMC Systems Biology 2009, 3:39 (14April2009)
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Research article
Constraint-based analysis of metabolic capacity of Salmonella typhimurium during host-pathogen interaction
Anu Raghunathan, Jennifer Reed, Sookil Shin, Bernhard Palsson, Simon Daefler
BMC Systems Biology 2009, 3:38 (8April2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Connecting extracellular metabolomic measurements to intracellular flux states in yeast
Monica L Mo, Bernhard Palsson, Markus J Herrgrd
BMC Systems Biology 2009, 3:37 (25March2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Research article
Identifying disease-specific genes based on their topological significance in protein networks
Zoltn Dezs, Yuri Nikolsky, Tatiana Nikolskaya, Jeremy Miller, David Cherba, Craig Webb, Andrej Bugrim
BMC Systems Biology 2009, 3:36 (23March2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [F1000 Biology]

Research article
Information processing in the transcriptional regulatory network of yeast: Functional robustness
Frank Emmert-Streib, Matthias Dehmer
BMC Systems Biology 2009, 3:35 (19March2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Methodology article
Version control of pathway models using XML patches
Peter Saffrey, Richard Orton
BMC Systems Biology 2009, 3:34 (17March2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Reconstruction of metabolic pathways for the cattle genome
Seongwon Seo, Harris A Lewin
BMC Systems Biology 2009, 3:33 (12March2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Research article
Topological and organizational properties of the products of house-keeping and tissue-specific genes in protein-protein interaction networks
Wen-hsien Lin, Wei-chung Liu, Ming-jing Hwang
BMC Systems Biology 2009, 3:32 (11March2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
Jesse J Smith, Rene Deehan Kenney, David J Gagne, Brian P Frushour, William Ladd, Heidi L Galonek, Kristine Israelian, Jeffrey Song, Giedre Razvadauskaite, Amy V Lynch, David P Carney, Robin J Johnson, Siva Lavu, Andre Iffland, Peter J Elliott, Philip D Lambert, Keith O Elliston, Michael R Jirousek, Jill C Milne, Olivier Boss
BMC Systems Biology 2009, 3:31 (10March2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article
Decomposing complex reaction networks using random sampling, principal component analysis and basis rotation
Christian L Barrett, Markus J Herrgard, Bernhard Palsson
BMC Systems Biology 2009, 3:30 (6March2009)
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Research article
Simple molecular networks that respond optimally to time-periodic stimulation
Axel Cournac, Jacques-Alexandre Sepulchre
BMC Systems Biology 2009, 3:29 (3March2009)
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Research article
Protein-protein interaction as a predictor of subcellular location
Chang Jin Shin, Simon Wong, Melissa J Davis, Mark A Ragan
BMC Systems Biology 2009, 3:28 (25February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Correspondence
A framework for evolutionary systems biology
Laurence Loewe
BMC Systems Biology 2009, 3:27 (24February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Software
FORG3D: Force-directed 3D graph editor for visualization of integrated genome scale data
Jussi Paananen, Garry Wong
BMC Systems Biology 2009, 3:26 (24February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Efficient, sparse biological network determination
Elias August, Antonis Papachristodoulou
BMC Systems Biology 2009, 3:25 (23February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Research article
A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola
Gavin H Thomas, Jeremy Zucker, Sandy J Macdonald, Anatoly Sorokin, Igor Goryanin, Angela E Douglas
BMC Systems Biology 2009, 3:24 (21February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway
Yukuto Sato, Yasuyuki Hashiguchi, Mutsumi Nishida
BMC Systems Biology 2009, 3:23 (20February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Research article
Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
Fan Wu, Daniel A Beard
BMC Systems Biology 2009, 3:22 (19February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Protein evolution on a human signaling network
Qinghua Cui, Enrico O Purisima, Edwin Wang
BMC Systems Biology 2009, 3:21 (18February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation
Albert C Huang, Limei Hu, Stuart A Kauffman, Wei Zhang, Ilya Shmulevich
BMC Systems Biology 2009, 3:20 (18February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation
Reza Mobini, Bengt A Andersson, Jonas Erjeflt, Mirjana Hahn-Zoric, Michael A Langston, Andy D Perkins, Lars Olaf Cardell, Mikael Benson
BMC Systems Biology 2009, 3:19 (12February2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Research article
mRNA stability and the unfolding of gene expression in the long-period yeast metabolic cycle
Nicola Soranzo, Mattia Zampieri, Lorenzo Farina, Claudio Altafini
BMC Systems Biology 2009, 3:18 (6February2009)
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Research article
Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3
Donatella Cimini, Kiran R Patil, Chiara Schiraldi, Jens Nielsen
BMC Systems Biology 2009, 3:17 (6February2009)
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Correspondence
On gene dosage balance in protein complexes: a comment on Semple JI, Vavouri T, Lehner B. A simple principle concerning the robustness of protein complex activity to changes in gene expression.
Reiner A Veitia
BMC Systems Biology 2009, 3:16 (30January2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Genome-scale constraint-based modeling of Geobacter metallireducens
Jun Sun, Bahareh Sayyar, Jessica E Butler, Priti Pharkya, Tom R Fahland, Iman Famili, Christophe H Schilling, Derek R Lovley, Radhakrishnan Mahadevan
BMC Systems Biology 2009, 3:15 (28January2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article
Coordinations between gene modules control the operation of plant amino acid metabolic networks
Hadar Less, Gad Galili
BMC Systems Biology 2009, 3:14 (26January2009)
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Research article
Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting
Amina A Qutub, Aleksander S Popel
BMC Systems Biology 2009, 3:13 (26January2009)
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Catherine F Higham
BMC Systems Biology 2009, 3:12 (26January2009)
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A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs
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BMC Systems Biology 2009, 3:11 (21January2009)
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Software
SNAVI: Desktop application for analysis and visualization of large-scale signaling networks
Avi Ma'ayan, Sherry L Jenkins, Ryan L Webb, Seth I Berger, Sudarshan P Purushothaman, Noura S Abul-Husn, Jeremy M Posner, Tony Flores, Ravi Iyengar
BMC Systems Biology 2009, 3:10 (20January2009)
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