BMC Structural Biology | Crystallography section

1.

Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment

Joanne E Nettleship, Jingshan Ren, David J Scott, Nahid Rahman, Deborah Hatherley, Yuguang Zhao, David I Stuart, A Barclay, Raymond J Owens BMC Structural Biology 2013, 13:13 (4 July 2013)

Crystallisation of signal regulatory protein SIRPgamma complexed with the Fab fragment of the OX117 antibody reveals conservation of binding domains between members of the SIRP family and dimerization specific to the crystal structure.

2.

The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the β-clamp processivity factor

Atif A Patoli, Jody A Winter, Karen A Bunting BMC Structural Biology 2013, 13:12 (4 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

3.

Crystal structure of the C-terminal globular domain of the third paralog of the Archaeoglobus fulgidus oligosaccharyltransferases

Shunsuke Matsumoto, Atsushi Shimada, Daisuke Kohda BMC Structural Biology 2013, 13:11 (1 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

4.

Crystal structure of putative CbiT from Methanocaldococcus jannaschii: an intermediate enzyme activity in cobalamin (vitamin B₁₂) biosynthesis

Balasundaram Padmanabhan, Shigeyuki Yokoyama, Yoshitaka Bessho BMC Structural Biology 2013, 13:10 (20 May 2013)

Abstract | Full text | PDF | PubMed

5.

A structural role for the PHP domain in E. coli DNA polymerase III

Tiago Barros, Joel Guenther, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O’Donnell, John Kuriyan, Meindert H Lamers BMC Structural Biology 2013, 13:8 (14 May 2013)

Metal binding can be restored to E. coli polymerase III PHP domain with only three point mutations, demonstrating that the domain structure is highly conserved and is a major structural element of this bacterial replicative polymerase.

6.

Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC

Jungwook Kim, Steven C Almo BMC Structural Biology 2013, 13:5 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos, Albert M Berghuis BMC Structural Biology 2012, 12:32 (12 December 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Three crystal structures of human farnesyl pyrophosphate synthase (FPPS) in ternary complex with a novel bisphosphonate inhibitor reveal mechanistic insight of the conformational change in the C-terminal tail closure that is essential for catalysis.

8.

Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface

Sagar Chittori, Handanahal S Savithri, Mathur RN Murthy BMC Structural Biology 2012, 12:24 (2 October 2012)

Abstract | Full text | PDF | PubMed

9.

Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation

Xiuhua Liu, Jing Gong, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu, Lichuan Gu BMC Structural Biology 2012, 12:23 (26 September 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Structural mismatch between the only heme storage protein of Vibrio cholera, HutZ, and its homologous protein HugZ, suggests that deficiency in heme oxygenase activity might derive from a single residue shift.

10.

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart, Kevin Woller, Robert V Talanian BMC Structural Biology 2012, 12:22 (20 September 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

The mouse Tyk2 protein kinase complexed to an ATP-competitive 3-aminoindazole inhibitor is stabilized relative to the unliganded enzyme, with the crystal structure revealing key differences in the glycine-rich loop conformation compared to those in human orthologs.

	All
	1.	Research article Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment Joanne E Nettleship, Jingshan Ren, David J Scott, Nahid Rahman, Deborah Hatherley, Yuguang Zhao, David I Stuart, A Barclay, Raymond J Owens BMC Structural Biology 2013, 13:13 (4 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Crystallisation of signal regulatory protein SIRPgamma complexed with the Fab fragment of the OX117 antibody reveals conservation of binding domains between members of the SIRP family and dimerization specific to the crystal structure.
	2.	Research article The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the β-clamp processivity factor Atif A Patoli, Jody A Winter, Karen A Bunting BMC Structural Biology 2013, 13:12 (4 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	3.	Research article Crystal structure of the C-terminal globular domain of the third paralog of the Archaeoglobus fulgidus oligosaccharyltransferases Shunsuke Matsumoto, Atsushi Shimada, Daisuke Kohda BMC Structural Biology 2013, 13:11 (1 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	4.	Research article Crystal structure of putative CbiT from Methanocaldococcus jannaschii: an intermediate enzyme activity in cobalamin (vitamin B₁₂) biosynthesis Balasundaram Padmanabhan, Shigeyuki Yokoyama, Yoshitaka Bessho BMC Structural Biology 2013, 13:10 (20 May 2013) Abstract \| Full text \| PDF \| PubMed
	5.	Research article A structural role for the PHP domain in E. coli DNA polymerase III Tiago Barros, Joel Guenther, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O’Donnell, John Kuriyan, Meindert H Lamers BMC Structural Biology 2013, 13:8 (14 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Metal binding can be restored to E. coli polymerase III PHP domain with only three point mutations, demonstrating that the domain structure is highly conserved and is a major structural element of this bacterial replicative polymerase.
	6.	Research article Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC Jungwook Kim, Steven C Almo BMC Structural Biology 2013, 13:5 (24 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	7.	Research article Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos, Albert M Berghuis BMC Structural Biology 2012, 12:32 (12 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Three crystal structures of human farnesyl pyrophosphate synthase (FPPS) in ternary complex with a novel bisphosphonate inhibitor reveal mechanistic insight of the conformational change in the C-terminal tail closure that is essential for catalysis.
	8.	Research article Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface Sagar Chittori, Handanahal S Savithri, Mathur RN Murthy BMC Structural Biology 2012, 12:24 (2 October 2012) Abstract \| Full text \| PDF \| PubMed
	9.	Research article Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation Xiuhua Liu, Jing Gong, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu, Lichuan Gu BMC Structural Biology 2012, 12:23 (26 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Structural mismatch between the only heme storage protein of Vibrio cholera, HutZ, and its homologous protein HugZ, suggests that deficiency in heme oxygenase activity might derive from a single residue shift.
	10.	Research article Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart, Kevin Woller, Robert V Talanian BMC Structural Biology 2012, 12:22 (20 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mouse Tyk2 protein kinase complexed to an ATP-competitive 3-aminoindazole inhibitor is stabilized relative to the unliganded enzyme, with the crystal structure revealing key differences in the glycine-rich loop conformation compared to those in human orthologs.

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