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76.

100
Accesses

Research article   Open Access Highly Accessed

Computational analysis of a novel mutation in ETFDH gene highlights its long-range effects on the FAD-binding motif

Tze-Kiong Er, Chih-Chieh Chen, Yen-Yi Liu, Hui-Chiu Chang, Yin-Hsiu Chien, Jan-Gowth Chang, Jenn-Kang Hwang, Yuh-Jyh Jong BMC Structural Biology 2011, 11:43 (21 October 2011)

Abstract | Full text | PDF | PubMed

77.

100
Accesses

Research article   Open Access Highly Accessed

Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation

Xiuhua Liu, Jing Gong, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu, Lichuan Gu BMC Structural Biology 2012, 12:23 (26 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Structural mismatch between the only heme storage protein of Vibrio cholera, HutZ, and its homologous protein HugZ, suggests that deficiency in heme oxygenase activity might derive from a single residue shift.

78.

100
Accesses

Research article   Open Access Highly Accessed

Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications

Laure Gabison, Thierry Prangé, Nathalie Colloc'h, Mohamed El Hajji, Bertrand Castro, Mohamed Chiadmi BMC Structural Biology 2008, 8:32 (20 July 2008)

Abstract | Full text | PDF | PubMed

79.

99
Accesses

Research article   Open Access

Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: Towards the design of higher-affinity inhibitors

Corinne Hazan, François Boudsocq, Virginie Gervais, Olivier Saurel, Marion Ciais, Christophe Cazaux, Jerzy Czaplicki, Alain Milon BMC Structural Biology 2008, 8:22 (16 April 2008)

Abstract | Full text | PDF | PubMed

80.

98
Accesses

Research article   Open Access Highly Accessed

Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach

Chiara Parravicini, Maria P Abbracchio, Piercarlo Fantucci, Graziella Ranghino BMC Structural Biology 2010, 10:8 (16 March 2010)

Abstract | Full text | PDF | PubMed | 1 comment

81.

98
Accesses

Research article   Open Access

Secondary structure of protamine in sperm nuclei: an infrared spectroscopy study

Alicia Roque, Inma Ponte, Pedro Suau BMC Structural Biology 2011, 11:14 (24 March 2011)

Abstract | Full text | PDF | PubMed

82.

98
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Research article   Open Access Highly Accessed

In silico identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex

Lorena Novoa-Aponte, Andrés León-Torres, Miyer Patiño-Ruiz, Jenifer Cuesta-Bernal, Luz-Mary Salazar, David Landsman, Leonardo Mariño-Ramírez, Carlos-Yesid Soto BMC Structural Biology 2012, 12:25 (3 October 2012)

Abstract | Full text | PDF | PubMed

83.

98
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Research article   Open Access Highly Accessed

Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics

Andrew J Antczak, Toshiaki Tsubota, Paul D Kaufman, James M Berger BMC Structural Biology 2006, 6:26 (13 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

84.

96
Accesses

Research article   Open Access Highly Accessed

Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control

Veljko Veljkovic, Nevena Veljkovic, Claude P Muller, Sybille Müller, Sanja Glisic, Vladimir Perovic, Heinz Köhler BMC Structural Biology 2009, 9:21 (7 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

85.

97
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Research article   Open Access Highly Accessed

Structural insight into the substrate- and dioxygen-binding manner in the catalytic cycle of rieske nonheme iron oxygenase system, carbazole 1,9a-dioxygenase

Yuji Ashikawa, Zui Fujimoto, Yusuke Usami, Kengo Inoue, Haruko Noguchi, Hisakazu Yamane, Hideaki Nojiri BMC Structural Biology 2012, 12:15 (24 June 2012)

Abstract | Full text | PDF | PubMed

86.

97
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Research article   Open Access Highly Accessed

Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1α and PKR

Govindarajan Sudha, Subburaj Yamunadevi, Nidhi Tyagi, Saumitra Das, Narayanaswamy Srinivasan BMC Structural Biology 2012, 12:28 (13 November 2012)

Abstract | Full text | PDF | PubMed

87.

97
Accesses

Methodology article   Open Access

MTMDAT-HADDOCK: High-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry

Janosch Hennig, Sjoerd J de Vries, Klaus DM Hennig, Leah Randles, Kylie J Walters, Maria Sunnerhagen, Alexandre MJJ Bonvin BMC Structural Biology 2012, 12:29 (15 November 2012)

Abstract | Full text | PDF | PubMed

88.

95
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Research article   Open Access Highly Accessed

Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE)

Shu Liu, Rao Fu, Xiao Cheng, Sheng-Ping Chen, Li-Hua Zhou BMC Structural Biology 2012, 12:21 (27 August 2012)

Abstract | Full text | PDF | PubMed

89.

92
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Research article   Open Access Highly Accessed

Energetics of the protein-DNA-water interaction

Francesca Spyrakis, Pietro Cozzini, Chiara Bertoli, Anna Marabotti, Glen E Kellogg, Andrea Mozzarelli BMC Structural Biology 2007, 7:4 (10 January 2007)

Abstract | Full text | PDF | PubMed

90.

95
Accesses

Research article   Open Access Highly Accessed

Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain

Jane A Potter, Richard E Randall, Garry L Taylor BMC Structural Biology 2008, 8:11 (28 February 2008)

Abstract | Full text | PDF | PubMed

91.

96
Accesses

Software   Open Access Highly Accessed

PTools: an opensource molecular docking library

Adrien Saladin, Sébastien Fiorucci, Pierre Poulain, Chantal Prévost, Martin Zacharias BMC Structural Biology 2009, 9:27 (1 May 2009)

Abstract | Full text | PDF | PubMed

92.

94
Accesses

Research article   Open Access Highly Accessed

Analysis of proteins with the 'hot dog' fold: Prediction of function and identification of catalytic residues of hypothetical proteins

Lakshmi S Pidugu, Koustav Maity, Karthikeyan Ramaswamy, Namita Surolia, Kaza Suguna BMC Structural Biology 2009, 9:37 (28 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

93.

94
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Research article   Open Access Highly Accessed

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

Jonathan A Winger, Emily R Derbyshire, Meindert H Lamers, Michael A Marletta, John Kuriyan BMC Structural Biology 2008, 8:42 (7 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The first crystal structure of a eukaryotic guanylate cyclase - from the green alga, Chlamydomonas reinhardtii - confirms the expected close structural similarity with adenylate cyclases and provides clues as to how activation of the enzyme could occur.

94.

93
Accesses

Research article   Open Access Highly Accessed

On the origin of the histone fold

Vikram Alva, Moritz Ammelburg, Johannes Söding, Andrei N Lupas BMC Structural Biology 2007, 7:17 (28 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A helix-strand-helix motif that probably gave rise to a domain in both Hsp100 and AAA+ proteins was further adapted by 3D domain-swapping to result in the unique histone fold.

95.

91
Accesses

Research article   Open Access Highly Accessed

Central domain deletions affect the SAXS solution structure and function of Yeast Hsp40 proteins Sis1 and Ydj1

Julio C Silva, Julio C Borges, Douglas M Cyr, Carlos HI Ramos, Iris L Torriani BMC Structural Biology 2011, 11:40 (19 October 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Deletion of the central ZFLR-CTDI domain in the Hsp40 protein Ydj1 changes the relative position of the J-domain, suggesting that interactions between these domains are important in determining the unique quaternary structure of Type I Hsp40s

96.

91
Accesses

Research article   Open Access

Docking studies on novel analogues of 8 methoxy fluoroquinolones against GyrA mutants of Mycobacterium tuberculosis

RS Anand, Sulochana Somasundaram, Mukesh Doble, CN Paramasivan BMC Structural Biology 2011, 11:47 (12 December 2011)

Abstract | Full text | PDF | PubMed

97.

91
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Research article   Open Access Highly Accessed

Binding of Sudan II and IV to lecithin liposomes and E. coli membranes: insights into the toxicity of hydrophobic azo dyes

Lu Li, Hong-Wen Gao, Jiao-Rong Ren, Ling Chen, Yu-Cheng Li, Jian-Fu Zhao, He-Ping Zhao, Yuan Yuan BMC Structural Biology 2007, 7:16 (27 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

98.

91
Accesses

Research article   Open Access

Engineering of PA-IIL lectin from Pseudomonas aeruginosa – Unravelling the role of the specificity loop for sugar preference

Jan Adam, Martina Pokorná, Charles Sabin, Edward P Mitchell, Anne Imberty, Michaela Wimmerová BMC Structural Biology 2007, 7:36 (1 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

99.

90
Accesses

Research article   Open Access Highly Accessed

Solution structure of the human signaling protein RACK1

Kaliandra A Gonçalves, Julio C Borges, Julio C Silva, Priscila F Papa, Gustavo C Bressan, Iris L Torriani, Jörg Kobarg BMC Structural Biology 2010, 10:15 (8 June 2010)

Abstract | Full text | PDF | PubMed

100.

90
Accesses

Research article   Open Access Highly Accessed

Molecular models for intrastrand DNA G-quadruplexes

Federico Fogolari, Haritha Haridas, Alessandra Corazza, Paolo Viglino, Davide Corà, Michele Caselle, Gennaro Esposito, Luigi E Xodo BMC Structural Biology 2009, 9:64 (7 October 2009)

Abstract | Full text | PDF | PubMed

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