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	51. 6801 Accesses	Research article Functional evolution of two subtly different (similar) folds Vishal Agrawal, Radha KV Kishan BMC Structural Biology 2001, 1:5 (21 December 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	52. 6642 Accesses	Research article Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression Laura Piccagli, Enrica Fabbri, Monica Borgatti, Valentino Bezzerri, Irene Mancini, Elena Nicolis, Maria C Dechecchi, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari BMC Structural Biology 2008, 8:38 (3 September 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Predicting the docking of 27 molecules from medicinal plants to NFkb-p50 helped identify a new lead compound shown experimentally to inhibit NFkb-p50 and modulate the expression of the NFkb-regulated gene IL8.
	53. 6565 Accesses	Research article Structural analysis of hemicatenated DNA loops Claire Gaillard, Luda S Shlyakhtenko, Yuri L Lyubchenko, François Strauss BMC Structural Biology 2002, 2:7 (26 November 2002) Abstract \| Full text \| PDF \| PubMed
	54. 6507 Accesses	Research article Spectrum of disease-causing mutations in protein secondary structures Sofia Khan, Mauno Vihinen BMC Structural Biology 2007, 7:56 (29 August 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	55. 6390 Accesses	Research article Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase Sébastien Santini, Vincent Monchois, Nicolas Mouz, Cécile Sigoillot, Tristan Rousselle, Jean-Michel Claverie, Chantal Abergel BMC Structural Biology 2008, 8:33 (24 July 2008) Abstract \| Full text \| PDF \| PubMed
	56. 6321 Accesses	Research article Structural organization and interactions of transmembrane domains in tetraspanin proteins Oleg V Kovalenko, Douglas G Metcalf, William F DeGrado, Martin E Hemler BMC Structural Biology 2005, 5:11 (28 June 2005) Abstract \| Full text \| PDF \| PubMed
	57. 6227 Accesses	Research article Mechanisms for stabilisation and the maintenance of solubility in proteins from thermophiles Richard B Greaves, Jim Warwicker BMC Structural Biology 2007, 7:18 (29 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hyperthermophilic proteins have more charged groups and less burial of aromatic side chains than related proteins in organisms that grow at lower temperatures, which may prevent aggregation and stabilise the proteins.
	58. 6216 Accesses	Research article Sequence and structural features of carbohydrate binding in proteins and assessment of predictability using a neural network Adeel Malik, Shandar Ahmad BMC Structural Biology 2007, 7:1 (3 January 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	59. 6179 Accesses	Research article Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18 Benjamin E Willcox, Leonard M Thomas, Tara L Chapman, Astrid P Heikema, Anthony P West, Pamela J Bjorkman BMC Structural Biology 2002, 2:6 (11 October 2002) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The crystal structure of the cell surface receptor LIR-2 reveals differences that may explain why it binds only weakly to a human cytomegalovirus class I MHC homolog, whereas the highly-related LIR-1 binds strongly.
	60. 6140 Accesses	Research article Energetics of the protein-DNA-water interaction Francesca Spyrakis, Pietro Cozzini, Chiara Bertoli, Anna Marabotti, Glen E Kellogg, Andrea Mozzarelli BMC Structural Biology 2007, 7:4 (10 January 2007) Abstract \| Full text \| PDF \| PubMed
	61. 6108 Accesses	Research article A homology model of restriction endonuclease SfiI in complex with DNA Agnieszka A Chmiel, Janusz M Bujnicki, Krzysztof J Skowronek BMC Structural Biology 2005, 5:2 (24 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The threading approach for fold recognition indicates that the Type IIF restriction enzyme SfiI is more related to BglI, a Type IIP enzyme, than to other Type IIF enzymes, suggesting that tetramer formation evolved at least twice in the PD-DxK superfamily.
	62. 6067 Accesses	Research article Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase Guoyu Meng, Klaus Fütterer BMC Structural Biology 2008, 8:16 (17 March 2008) Abstract \| Full text \| PDF \| PubMed
	63. 6019 Accesses	Software PTools: an opensource molecular docking library Adrien Saladin, Sébastien Fiorucci, Pierre Poulain, Chantal Prévost, Martin Zacharias BMC Structural Biology 2009, 9:27 (1 May 2009) Abstract \| Full text \| PDF \| PubMed
	64. 5988 Accesses	Research article A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor Dionys Weber, Alexander Kotzsch, Joachim Nickel, Stefan Harth, Axel Seher, Uwe Mueller, Walter Sebald, Thomas D Mueller BMC Structural Biology 2007, 7:6 (12 February 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The binding specificity of BMP-2 for its receptors is dramatically changed by mutations in only one or two residues, in particular mutations activating a conserved H-bond that controls a switch from low- to high-affinity binding.
	65. 5923 Accesses	Research article Comparative Analysis of Protein Structure Alignments Gabriele Mayr, Francisco S Domingues, Peter Lackner BMC Structural Biology 2007, 7:50 (26 July 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A rigorous framework for objectively comparing 3D protein structure alignment programs shows that although alignments produced by different methods tend to agree, there is still room for improvement on more challenging protein pairs.
	66. 5896 Accesses	Research article Cα-H···O=C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions Jordi Bella, Martin J Humphries BMC Structural Biology 2005, 5:4 (14 February 2005) Abstract \| Full text \| PDF \| PubMed
	67. 5885 Accesses	Research article Types of inter-atomic interactions at the MHC-peptide interface: Identifying commonality from accumulated data Png Adrian, Ganapathy Rajaseger, Venkatarajan Mathura, Meena Sakharkar, Pandjassarame Kangueane BMC Structural Biology 2002, 2:2 (13 May 2002) Abstract \| Full text \| PDF \| PubMed
	68. 5736 Accesses	Research article On the origin of the histone fold Vikram Alva, Moritz Ammelburg, Johannes Söding, Andrei N Lupas BMC Structural Biology 2007, 7:17 (28 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A helix-strand-helix motif that probably gave rise to a domain in both Hsp100 and AAA+ proteins was further adapted by 3D domain-swapping to result in the unique histone fold.
	69. 5664 Accesses	Research article An in silico study of the molecular basis of B-RAF activation and conformational stability Filip F Fratev, Svava Jónsdóttir BMC Structural Biology 2009, 9:47 (22 July 2009) Abstract \| Full text \| PDF \| PubMed
	70. 5631 Accesses	Research article The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor Marcel Winnig, Bernd Bufe, Nicole A Kratochwil, Jay P Slack, Wolfgang Meyerhof BMC Structural Biology 2007, 7:66 (12 October 2007) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The artificial sweetener neohesperidin dihydrochalcone activates human, but not rat, taste receptors and using chimeric rat-human receptors its binding site was found to overlap that of the sweetener cyclamate and the sweet-taste inhibitor lactisole.
	71. 5502 Accesses	Research article Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center Kumar Saikatendu, Xuejun Zhang, Lisa Kinch, Matthew Leybourne, Nick V Grishin, Hong Zhang BMC Structural Biology 2006, 6:27 (23 December 2006) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mysterious NIF3-like protein family may help regulate nitrogen, a prediction supported by a Staphylococcus aureus protein structure consisting of a hexameric ring of NIF3 domains with a ligand bound at a metal site.
	72. 5494 Accesses	Research article Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetases Balachandran Manavalan, Senthil K Murugapiran, Gwang Lee, Sangdun Choi BMC Structural Biology 2010, 10:1 (12 January 2010) Abstract \| Full text \| PDF \| PubMed
	73. 5431 Accesses	Research article Modelling substrate specificity and enantioselectivity for lipases and esterases by substrate-imprinted docking P Benjamin Juhl, Peter Trodler, Sadhna Tyagi, Jürgen Pleiss BMC Structural Biology 2009, 9:39 (3 June 2009) Abstract \| Full text \| PDF \| PubMed
	74. 5424 Accesses	Research article A comprehensive analysis of 40 blind protein structure predictions Ram Samudrala, Michael Levitt BMC Structural Biology 2002, 2:3 (1 August 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	75. 5394 Accesses	Research article X-ray sequence and crystal structure of luffaculin 1, a novel type 1 ribosome-inactivating protein Xiaomin Hou, Minghuang Chen, Liqing Chen, Edward J Meehan, Jieming Xie, Mingdong Huang BMC Structural Biology 2007, 7:29 (30 April 2007) Abstract \| Full text \| PDF \| PubMed