biomedcentral.com/bmcstructbiol/article
Bottom,Top,Right1
  • Welcome Stanford University
  • Log on
  •   BioMed Central
  • Journals
  • Gateways
BMC Structural Biology
official impact factor 2.48
Search for
Advanced search
  • Home
  • Articles
  • Authors
  • Reviewers
  • About this journal
  • My BMC Structural Biology

Submit a manuscript Register Sign up for article alerts Contact us Follow us on Twitter

Explore journal

  •  Editorial Board
  •  Instructions for authors
  •  FAQ
Advertisement

Articles

  • All articles
  • Sections
  • Most viewed RSS
      • Last 30 days
      • Last year
      • All time
  • Archive
  • Supplements

Page 1 of 4

1 2 3 4  Next

 Display/download options Articles per page: 25 | 50 | 100

Display options
Download optionsHelp icon

1.

1541
Accesses

Research article   Open Access Highly Accessed

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

Jonathan A Winger, Oliver Hantschel, Giulio Superti-Furga, John Kuriyan BMC Structural Biology 2009, 9:7 (24 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The tyrosine-kinase inhibitor imatinib is revealed by X-ray crystallography to occupy the active site of the oxidoreductase NQO2, a secondary target whose inhibition may be responsible for side effects in leukaemia patients receiving treatment with the drug.

2.

864
Accesses

Research article   Open Access Highly Accessed

An in silico study of the molecular basis of B-RAF activation and conformational stability

Filip F Fratev, Svava Jónsdóttir BMC Structural Biology 2009, 9:47 (22 July 2009)

Abstract | Full text | PDF | PubMed

3.

751
Accesses

Research article   Open Access Highly Accessed

Theoretical investigation on structural, functional and epitope of a 12 kDa excretory-secretory protein from Toxoplasma gondii

Yap Boon Wooi Tommy, Theam Soon Lim, Rahmah Noordin, Geita Saadatnia, Yee Siew Choong BMC Structural Biology 2012, 12:30 (27 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The 3D structure of the 12 kDa excretory-secretory protein of Toxoplasma gondii reveals a thioredoxin-like backbone and three potential epitopes functioning as a single antibody binding site, aiding the development of an antigen detection test for toxoplasmosis.

4.

598
Accesses

Research article   Open Access Highly Accessed

The Ramachandran plots of glycine and pre-proline

Bosco K Ho, Robert Brasseur BMC Structural Biology 2005, 5:14 (16 August 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

517
Accesses

Research article   Open Access

Structural comparison of tRNA m1A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions

Amandine Guelorget, Pierre Barraud, Carine Tisné, Béatrice Golinelli-Pimpaneau BMC Structural Biology 2011, 11:48 (14 December 2011)

Abstract | Full text | PDF | PubMed

6.

459
Accesses

Reviewer acknowledgement   Open Access

Annual acknowledgement of manuscript reviewers

Simon Harold BMC Structural Biology 2013, 13:1 (19 February 2013)

Abstract | Full text | PDF | PubMed

7.

338
Accesses

Research article   Open Access

The possible mechanisms of CYP2E1 interactions with HSP90 and the influence of ethanol on them

Volodymyr O Kitam, Oksana V Maksymchuk, Mykola O Chashchyn BMC Structural Biology 2012, 12:33 (17 December 2012)

Abstract | Full text | PDF | PubMed

8.

320
Accesses

Research article   Open Access Highly Accessed

Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE)

Shu Liu, Rao Fu, Xiao Cheng, Sheng-Ping Chen, Li-Hua Zhou BMC Structural Biology 2012, 12:21 (27 August 2012)

Abstract | Full text | PDF | PubMed

9.

314
Accesses

Research article   Open Access Highly Accessed

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos, Albert M Berghuis BMC Structural Biology 2012, 12:32 (12 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Three crystal structures of human farnesyl pyrophosphate synthase (FPPS) in ternary complex with a novel bisphosphonate inhibitor reveal mechanistic insight of the conformational change in the C-terminal tail closure that is essential for catalysis.

10.

290
Accesses

Software   Open Access Highly Accessed

Protein Nano-Object Integrator (ProNOI) for generating atomic style objects for molecular modeling

Nicholas Smith, Brandon Campbell, Lin Li, Chuan Li, Emil Alexov BMC Structural Biology 2012, 12:31 (5 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Protein Nano-Object Integrator (ProNOI) is a novel software tool for generating atomic-style nano shapes in conjunction with biological macromolecules, allowing users to manipulate shape, dimension and position, and charge objects with user-specified charge density.

11.

273
Accesses

Review   Open Access Highly Accessed

Integrative structural modeling with small angle X-ray scattering profiles

Dina Schneidman-Duhovny, Seung Kim, Andrej Sali BMC Structural Biology 2012, 12:17 (16 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Dina Schneidman-Duhovny and colleagues review the use of Small-Angle X-ray Scattering (SAXS) profiles for the structural modeling of proteins, nucleic acids and their complexes, and propose an integrative approach combining multiple datasets to help discriminate among ambiguous models.

12.

270
Accesses

Research article   Open Access Highly Accessed

Spectrum of disease-causing mutations in protein secondary structures

Sofia Khan, Mauno Vihinen BMC Structural Biology 2007, 7:56 (29 August 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

269
Accesses

Research article   Open Access Highly Accessed

Evolutionarily consistent families in SCOP: sequence, structure and function

Ralph B Pethica, Michael Levitt, Julian Gough BMC Structural Biology 2012, 12:27 (18 October 2012)

Abstract | Full text | PDF | PubMed

14.

267
Accesses

Research article   Open Access Highly Accessed

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine

Matthieu Schapira, Ruben Abagyan, Maxim Totrov BMC Structural Biology 2002, 2:1 (18 January 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

249
Accesses

Research article   Open Access Highly Accessed

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

Gerhard Schenk, Tristan W Elliott, Eleanor Leung, Lyle E Carrington, Nataša Mitić, Lawrence R Gahan, Luke W Guddat BMC Structural Biology 2008, 8:6 (31 January 2008)

Abstract | Full text | PDF | PubMed

16.

243
Accesses

Research article   Open Access Highly Accessed

Dependence of α-helical and β-sheet amino acid propensities on the overall protein fold type

Kazuo Fujiwara, Hiromi Toda, Masamichi Ikeguchi BMC Structural Biology 2012, 12:18 (2 August 2012)

Abstract | Full text | PDF | PubMed

17.

244
Accesses

Research article   Open Access Highly Accessed

In silico identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex

Lorena Novoa-Aponte, Andrés León-Torres, Miyer Patiño-Ruiz, Jenifer Cuesta-Bernal, Luz-Mary Salazar, David Landsman, Leonardo Mariño-Ramírez, Carlos-Yesid Soto BMC Structural Biology 2012, 12:25 (3 October 2012)

Abstract | Full text | PDF | PubMed

18.

240
Accesses

Research article   Open Access Highly Accessed

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart, Kevin Woller, Robert V Talanian BMC Structural Biology 2012, 12:22 (20 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The mouse Tyk2 protein kinase complexed to an ATP-competitive 3-aminoindazole inhibitor is stabilized relative to the unliganded enzyme, with the crystal structure revealing key differences in the glycine-rich loop conformation compared to those in human orthologs.

19.

236
Accesses

Research article   Open Access Highly Accessed

Structural analysis of heme proteins: implications for design and prediction

Ting Li, Herbert L Bonkovsky, Jun-tao Guo BMC Structural Biology 2011, 11:13 (3 March 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Heme binding pockets provide a hydrophobic environment for the heme ring structure, being enriched in aromatic and non-polar amino acids, with most heme proteins undergoing small conformational changes after heme binding.

20.

233
Accesses

Methodology article   Open Access Highly Accessed

Screening of transgenic proteins expressed in transgenic food crops for the presence of short amino acid sequences identical to potential, IgE – binding linear epitopes of allergens

Gijs A Kleter, Ad ACM Peijnenburg BMC Structural Biology 2002, 2:8 (12 December 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

233
Accesses

Research article   Open Access Highly Accessed

Natural history of S-adenosylmethionine-binding proteins

Piotr Z Kozbial, Arcady R Mushegian BMC Structural Biology 2005, 5:19 (14 October 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Analysis of the phyletic distribution and structural similarities of S-adenosylmethionine-binding proteins indicate that two widespread folds, the Rossman fold and TIM barrel, have repeatedly evolved for diverse types of reactions that require S-adenosylmethionine.

22.

230
Accesses

Research article   Open Access Highly Accessed

Crystal structural analysis of human serum albumin complexed with hemin and fatty acid

Patricia A Zunszain, Jamie Ghuman, Teruyuki Komatsu, Eishun Tsuchida, Stephen Curry BMC Structural Biology 2003, 3:6 (7 July 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The structure of a human serum albumin-hemin-myristate complex reveals a new conformation plus key polar and hydrophobic interactions that should be useful in designing HSA-heme complexes with modified oxygen-binding properties.

23.

228
Accesses

Research article   Open Access Highly Accessed

Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface

Alessandro Siglioccolo, Alessandro Paiardini, Maria Piscitelli, Stefano Pascarella BMC Structural Biology 2011, 11:50 (22 December 2011)

Abstract | Full text | PDF | PubMed

24.

212
Accesses

Research article   Open Access Highly Accessed

Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1α and PKR

Govindarajan Sudha, Subburaj Yamunadevi, Nidhi Tyagi, Saumitra Das, Narayanaswamy Srinivasan BMC Structural Biology 2012, 12:28 (13 November 2012)

Abstract | Full text | PDF | PubMed

25.

200
Accesses

Research article   Open Access Highly Accessed

Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation

Xiuhua Liu, Jing Gong, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu, Lichuan Gu BMC Structural Biology 2012, 12:23 (26 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Structural mismatch between the only heme storage protein of Vibrio cholera, HutZ, and its homologous protein HugZ, suggests that deficiency in heme oxygenase activity might derive from a single residue shift.

Page 1 of 4

1 2 3 4  Next


  • Terms and Conditions
  • Privacy statement
  • Press
  • Information for advertisers
  • Jobs at BMC
  • Support
  • Contact us

© 2013 BioMed Central Ltd unless otherwise stated. Part of Springer Science+Business Media.