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	1. 1541 Accesses	Research article The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2) Jonathan A Winger, Oliver Hantschel, Giulio Superti-Furga, John Kuriyan BMC Structural Biology 2009, 9:7 (24 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The tyrosine-kinase inhibitor imatinib is revealed by X-ray crystallography to occupy the active site of the oxidoreductase NQO2, a secondary target whose inhibition may be responsible for side effects in leukaemia patients receiving treatment with the drug.
	2. 864 Accesses	Research article An in silico study of the molecular basis of B-RAF activation and conformational stability Filip F Fratev, Svava Jónsdóttir BMC Structural Biology 2009, 9:47 (22 July 2009) Abstract \| Full text \| PDF \| PubMed
	3. 751 Accesses	Research article Theoretical investigation on structural, functional and epitope of a 12 kDa excretory-secretory protein from Toxoplasma gondii Yap Boon Wooi Tommy, Theam Soon Lim, Rahmah Noordin, Geita Saadatnia, Yee Siew Choong BMC Structural Biology 2012, 12:30 (27 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The 3D structure of the 12 kDa excretory-secretory protein of Toxoplasma gondii reveals a thioredoxin-like backbone and three potential epitopes functioning as a single antibody binding site, aiding the development of an antigen detection test for toxoplasmosis.
	4. 598 Accesses	Research article The Ramachandran plots of glycine and pre-proline Bosco K Ho, Robert Brasseur BMC Structural Biology 2005, 5:14 (16 August 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	5. 517 Accesses	Research article Structural comparison of tRNA m¹A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions Amandine Guelorget, Pierre Barraud, Carine Tisné, Béatrice Golinelli-Pimpaneau BMC Structural Biology 2011, 11:48 (14 December 2011) Abstract \| Full text \| PDF \| PubMed
	6. 459 Accesses	Reviewer acknowledgement Annual acknowledgement of manuscript reviewers Simon Harold BMC Structural Biology 2013, 13:1 (19 February 2013) Abstract \| Full text \| PDF \| PubMed
	7. 338 Accesses	Research article The possible mechanisms of CYP2E1 interactions with HSP90 and the influence of ethanol on them Volodymyr O Kitam, Oksana V Maksymchuk, Mykola O Chashchyn BMC Structural Biology 2012, 12:33 (17 December 2012) Abstract \| Full text \| PDF \| PubMed
	8. 320 Accesses	Research article Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE) Shu Liu, Rao Fu, Xiao Cheng, Sheng-Ping Chen, Li-Hua Zhou BMC Structural Biology 2012, 12:21 (27 August 2012) Abstract \| Full text \| PDF \| PubMed
	9. 314 Accesses	Research article Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos, Albert M Berghuis BMC Structural Biology 2012, 12:32 (12 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Three crystal structures of human farnesyl pyrophosphate synthase (FPPS) in ternary complex with a novel bisphosphonate inhibitor reveal mechanistic insight of the conformational change in the C-terminal tail closure that is essential for catalysis.
	10. 290 Accesses	Software Protein Nano-Object Integrator (ProNOI) for generating atomic style objects for molecular modeling Nicholas Smith, Brandon Campbell, Lin Li, Chuan Li, Emil Alexov BMC Structural Biology 2012, 12:31 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Protein Nano-Object Integrator (ProNOI) is a novel software tool for generating atomic-style nano shapes in conjunction with biological macromolecules, allowing users to manipulate shape, dimension and position, and charge objects with user-specified charge density.
	11. 273 Accesses	Review Integrative structural modeling with small angle X-ray scattering profiles Dina Schneidman-Duhovny, Seung Kim, Andrej Sali BMC Structural Biology 2012, 12:17 (16 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dina Schneidman-Duhovny and colleagues review the use of Small-Angle X-ray Scattering (SAXS) profiles for the structural modeling of proteins, nucleic acids and their complexes, and propose an integrative approach combining multiple datasets to help discriminate among ambiguous models.
	12. 270 Accesses	Research article Spectrum of disease-causing mutations in protein secondary structures Sofia Khan, Mauno Vihinen BMC Structural Biology 2007, 7:56 (29 August 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	13. 269 Accesses	Research article Evolutionarily consistent families in SCOP: sequence, structure and function Ralph B Pethica, Michael Levitt, Julian Gough BMC Structural Biology 2012, 12:27 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
	14. 267 Accesses	Research article Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine Matthieu Schapira, Ruben Abagyan, Maxim Totrov BMC Structural Biology 2002, 2:1 (18 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	15. 249 Accesses	Research article Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle Gerhard Schenk, Tristan W Elliott, Eleanor Leung, Lyle E Carrington, Nataša Mitić, Lawrence R Gahan, Luke W Guddat BMC Structural Biology 2008, 8:6 (31 January 2008) Abstract \| Full text \| PDF \| PubMed
	16. 243 Accesses	Research article Dependence of α-helical and β-sheet amino acid propensities on the overall protein fold type Kazuo Fujiwara, Hiromi Toda, Masamichi Ikeguchi BMC Structural Biology 2012, 12:18 (2 August 2012) Abstract \| Full text \| PDF \| PubMed
	17. 244 Accesses	Research article In silico identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex Lorena Novoa-Aponte, Andrés León-Torres, Miyer Patiño-Ruiz, Jenifer Cuesta-Bernal, Luz-Mary Salazar, David Landsman, Leonardo Mariño-Ramírez, Carlos-Yesid Soto BMC Structural Biology 2012, 12:25 (3 October 2012) Abstract \| Full text \| PDF \| PubMed
	18. 240 Accesses	Research article Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart, Kevin Woller, Robert V Talanian BMC Structural Biology 2012, 12:22 (20 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mouse Tyk2 protein kinase complexed to an ATP-competitive 3-aminoindazole inhibitor is stabilized relative to the unliganded enzyme, with the crystal structure revealing key differences in the glycine-rich loop conformation compared to those in human orthologs.
	19. 236 Accesses	Research article Structural analysis of heme proteins: implications for design and prediction Ting Li, Herbert L Bonkovsky, Jun-tao Guo BMC Structural Biology 2011, 11:13 (3 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Heme binding pockets provide a hydrophobic environment for the heme ring structure, being enriched in aromatic and non-polar amino acids, with most heme proteins undergoing small conformational changes after heme binding.
	20. 233 Accesses	Methodology article Screening of transgenic proteins expressed in transgenic food crops for the presence of short amino acid sequences identical to potential, IgE – binding linear epitopes of allergens Gijs A Kleter, Ad ACM Peijnenburg BMC Structural Biology 2002, 2:8 (12 December 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	21. 233 Accesses	Research article Natural history of S-adenosylmethionine-binding proteins Piotr Z Kozbial, Arcady R Mushegian BMC Structural Biology 2005, 5:19 (14 October 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analysis of the phyletic distribution and structural similarities of S-adenosylmethionine-binding proteins indicate that two widespread folds, the Rossman fold and TIM barrel, have repeatedly evolved for diverse types of reactions that require S-adenosylmethionine.
	22. 230 Accesses	Research article Crystal structural analysis of human serum albumin complexed with hemin and fatty acid Patricia A Zunszain, Jamie Ghuman, Teruyuki Komatsu, Eishun Tsuchida, Stephen Curry BMC Structural Biology 2003, 3:6 (7 July 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The structure of a human serum albumin-hemin-myristate complex reveals a new conformation plus key polar and hydrophobic interactions that should be useful in designing HSA-heme complexes with modified oxygen-binding properties.
	23. 228 Accesses	Research article Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface Alessandro Siglioccolo, Alessandro Paiardini, Maria Piscitelli, Stefano Pascarella BMC Structural Biology 2011, 11:50 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	24. 212 Accesses	Research article Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1α and PKR Govindarajan Sudha, Subburaj Yamunadevi, Nidhi Tyagi, Saumitra Das, Narayanaswamy Srinivasan BMC Structural Biology 2012, 12:28 (13 November 2012) Abstract \| Full text \| PDF \| PubMed
	25. 200 Accesses	Research article Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation Xiuhua Liu, Jing Gong, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu, Lichuan Gu BMC Structural Biology 2012, 12:23 (26 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Structural mismatch between the only heme storage protein of Vibrio cholera, HutZ, and its homologous protein HugZ, suggests that deficiency in heme oxygenase activity might derive from a single residue shift.