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Volume 7 (2007) - March 2007

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Research article   Open Access

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase

Tanja Sgraja, Terry K Smith, William N Hunter BMC Structural Biology 2007, 7:20 (30 March 2007)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Leishmania mevalonate kinase has a conserved substrate binding site but a distinct co-factor binding site conformation, which could aid in finding therapeutic targets.

Research article   Open Access

Atomic hydration potentials using a Monte Carlo Reference State (MCRS) for protein solvation modeling

Sergei V Rakhmanov, Vsevolod J Makeev BMC Structural Biology 2007, 7:19 (30 March 2007)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Mechanisms for stabilisation and the maintenance of solubility in proteins from thermophiles

Richard B Greaves, Jim Warwicker BMC Structural Biology 2007, 7:18 (29 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Hyperthermophilic proteins have more charged groups and less burial of aromatic side chains than related proteins in organisms that grow at lower temperatures, which may prevent aggregation and stabilise the proteins.

Research article   Open Access Highly Accessed

On the origin of the histone fold

Vikram Alva, Moritz Ammelburg, Johannes Söding, Andrei N Lupas BMC Structural Biology 2007, 7:17 (28 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A helix-strand-helix motif that probably gave rise to a domain in both Hsp100 and AAA+ proteins was further adapted by 3D domain-swapping to result in the unique histone fold.

Research article   Open Access Highly Accessed

Binding of Sudan II and IV to lecithin liposomes and E. coli membranes: insights into the toxicity of hydrophobic azo dyes

Lu Li, Hong-Wen Gao, Jiao-Rong Ren, Ling Chen, Yu-Cheng Li, Jian-Fu Zhao, He-Ping Zhao, Yuan Yuan BMC Structural Biology 2007, 7:16 (27 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Scoring predictive models using a reduced representation of proteins: model and energy definition

Federico Fogolari, Lidia Pieri, Agostino Dovier, Luca Bortolussi, Gilberto Giugliarelli, Alessandra Corazza, Gennaro Esposito, Paolo Viglino BMC Structural Biology 2007, 7:15 (23 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft

Olgun Guvench, Cheng-Kui Qu, Alexander D MacKerell BMC Structural Biology 2007, 7:14 (22 March 2007)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A tyrosine residue of SHP-2, a tyrosine phosphatase, regulates conformational change in the protein's phosphotyrosine-peptide binding cleft in molecular dynamics simulations, which may pinpoint how mutations in the SHP-2 gene lead to leukemia.

Software   Open Access

Rappertk: a versatile engine for discrete restraint-based conformational sampling of macromolecules

Swanand P Gore, Anjum M Karmali, Tom L Blundell BMC Structural Biology 2007, 7:13 (21 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Protein structure prediction by all-atom free-energy refinement

Abhinav Verma, Wolfgang Wenzel BMC Structural Biology 2007, 7:12 (19 March 2007)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Crystal structures of an Extracytoplasmic Solute Receptor from a TRAP transporter in its open and closed forms reveal a helix-swapped dimer requiring a cation for α-keto acid binding

Sophie Gonin, Pascal Arnoux, Bénédicte Pierru, Jérôme Lavergne, Béatrice Alonso, Monique Sabaty, David Pignol BMC Structural Biology 2007, 7:11 (15 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Crystal structures of a Rhodobacter extracytoplasmic solute receptor (ESR) unexpectedly show dimers linked by helix swapping and the presence of a cation that is apparently central to solute binding.

Research article   Open Access

Structural investigations of the ferredoxin and terminal oxygenase components of the biphenyl 2,3-dioxygenase from Sphingobium yanoikuyae B1

Daniel J Ferraro, Eric N Brown, Chi-Li Yu, Rebecca E Parales, David T Gibson, S Ramaswamy BMC Structural Biology 2007, 7:10 (9 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Evaluation of the structural quality of modeled proteins by using globularity criteria

Susan Costantini, Angelo M Facchiano, Giovanni Colonna BMC Structural Biology 2007, 7:9 (9 March 2007)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Structure and characterization of a novel chicken biotin-binding protein A (BBP-A)

Vesa P Hytönen, Juha AE Määttä, Einari A Niskanen, Juhani Huuskonen, Kaisa J Helttunen, Katrin K Halling, Henri R Nordlund, Kari Rissanen, Mark S Johnson, Tiina A Salminen, Markku S Kulomaa, Olli H Laitinen, Tomi T Airenne BMC Structural Biology 2007, 7:8 (7 March 2007)

Abstract | Full text | PDF | PubMed


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