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    Chromatin modification and lysine context

    Molecular modeling of the recognition and modification of histones by the oncogenic NSD class of histone methyl transferases sheds light on the dynamics of these interactions, potentially aiding the design of inhibitors for chemotherapies.

    BMC Structural Biology 2014, 14:25
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    Antibiotic resistance in E. coli

    The structure of polymyxin B resistance protein D from E. coli reveals distinct features differing from those of closely related species that may help determine its mechanisms of antibiotic resistance.

    BMC Structural Biology 2014, 14:24
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    Bacterial pyruvate decarboxylase structure

    The Gluconacetobacter diazotrophicus enzyme responsible for breaking down pyruvate into acetaldehyde and carbon dioxide, an important intermediate step in the production of ethanol, is structurally similar to pyruvate decarboxylases from other bacterial species.

    BMC Structural Biology 2014, 14:21
  • Proteins from deep- vs shallow-water archaea

    Effects of extreme environments, such as high temperature and high pressure, on protein conformation were examined using molecular dynamics simulations, providing insight into the mechanisms of adaptations to deep water conditions in archaea.

    BMC Structural Biology 2014, 14:23
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    Molecular details of translation initiation

    A new model incorporates high resolution structural data from a recently crystallyzed initiation factor to elucidate the direct interactions between initiator tRNA and domain IV of eIF5B in the context of the yeast 80S ribosome.

    BMC Structural Biology 2014, 14:20
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