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	1. 484 Accesses	Methodology article Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish heart Satish Kitambi, Erik S Nilsson, Petra Sekyrova, Cristian Ibarra, Gilbert Tekeoh, Michael Andäng, Patrik Ernfors, Per Uhlén BMC Physiology 2012, 12:3 (26 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Zebrafish hearts can be used for screening the cardiovascular toxicity of small molecules in a new sensitive and reliable method that allows a variety of readouts, such as expression of biomarkers.
	2. 364 Accesses	Methodology article MicroCT for comparative morphology: simple staining methods allow high-contrast 3D imaging of diverse non-mineralized animal tissues Brian D Metscher BMC Physiology 2009, 9:11 (22 June 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary New staining procedures based on inorganic iodine and phosphotungstic acid can be used to produce high-contrast, high-resolution, quantitative 3-D images of soft animal tissues by x-ray microtomography (microCT), opening exciting new opportunities for non-destructive studies of animal morphology.
	3. 340 Accesses	Research article Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels Francisco JOSE Tinahones, Leticia Coin-Araguez, Maria DOLORES Mayas, Eduardo Garcia-Fuentes, Carmen HURTADO Del Pozo, Joan Vendrell, Fernando Cardona, Rosa MARIA Calvo, Maria JESUS Obregon, Rajaa El Bekay BMC Physiology 2012, 12:4 (2 April 2012) Abstract \| Provisional PDF \| PubMed
	4. 332 Accesses	Research article Mechanisms of pressure-diuresis and pressure-natriuresis in Dahl salt-resistant and Dahl salt-sensitive rats Daniel A Beard, Muriel Mescam BMC Physiology 2012, 12:6 (14 May 2012) Abstract \| Provisional PDF \| PubMed
	5. 312 Accesses	Research article Contractile Properties and Movement Behaviour in Neonatal Rats with Axotomy, treated with the NMDA Antagonist DAP5 Konstantinos Petsanis, Athanasios Chatzisotiriou, Dorothea Kapoukranidou, Constantina Simeonidou, Dimitrios Kouvelas, Maria Albani BMC Physiology 2012, 12:5 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Systemic administration of the NMDA antagonist DAP5 has positive effects on recovery of muscle contractile properties and motor behavior after sciatic nerve crush in neonatal rats and may have therapeutic potential in other models of excitotoxic injury.
	6. 297 Accesses	Research article Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers Noel N Kim, Miljan Stankovic, Tulay T Cushman, Irwin Goldstein, Ricardo Munarriz, Abdulmaged M Traish BMC Physiology 2006, 6:4 (30 May 2006) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Induction of diabetes in rats using streptozotocin results in vaginal alterations in histology, blood flow and levels of enzymes controlling genital response, which may explain the decline of sexual function in diabetic women.
	7. 267 Accesses	Research article Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions Paul A Watkins, Ann B Moser, Cicely B Toomer, Steven J Steinberg, Hugo W Moser, Mazen W Karaman, Krishna Ramaswamy, Kimberly D Siegmund, D Rick Lee, John J Ely, Oliver A Ryder, Joseph G Hacia BMC Physiology 2010, 10:19 (8 October 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	8. 237 Accesses	Research article Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure Cristi L Galindo, Michael A Skinner, Mounir Errami, L Danielle Olson, David A Watson, Jing Li, John F McCormick, Lauren J McIver, Neil M Kumar, Thinh Q Pham, Harold R Garner BMC Physiology 2009, 9:23 (9 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The transcriptional profile of cardiac hypertrophy induced by isoprotenol in mice differs significantly from that induced by exercise while cross-study comparisons reveal close parallels to human ischemia and a 64-gene expression signature shared by all failing hearts.
	9. 220 Accesses	Research article Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity Takehiko Oka, Yuhei Nishimura, Liqing Zang, Minoru Hirano, Yasuhito Shimada, Zhipeng Wang, Noriko Umemoto, Junya Kuroyanagi, Norihiro Nishimura, Toshio Tanaka BMC Physiology 2010, 10:21 (21 October 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A zebrafish model of diet-induced obesity shares common pathophysiological pathways with mammalian obesity, in particular those pathways relating to the blood coagulation cascade and fatty acid metabolism which appear to be conserved in zebrafish and mammals.
	10. 202 Accesses	Research article Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion Jennifer A Sanders, Christoph Schorl, Ajay Patel, John M Sedivy, Philip A Gruppuso BMC Physiology 2012, 12:1 (7 March 2012) Abstract \| Full text \| PDF \| PubMed
	11. 199 Accesses	Research article Transitions into and out of daylight saving time compromise sleep and the rest-activity cycles Tuuli A Lahti, Sami Leppämäki, Jouko Lönnqvist, Timo Partonen BMC Physiology 2008, 8:3 (12 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	12. 180 Accesses	Research article Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity Alexandre Dal-Pan, Stéphane Blanc, Fabienne Aujard BMC Physiology 2010, 10:11 (22 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The natural plant compound resveratrol reduces the winter body mass gain of gray mouse lemurs by increasing satiety and resting metabolic rate, highlighting the potential effects of this compound on body mass control in primates.
	13. 162 Accesses	Research article Physiological responses of Daphnia pulex to acid stress Anna K Weber, Ralph Pirow BMC Physiology 2009, 9:9 (21 April 2009) Abstract \| Full text \| PDF \| PubMed
	14. 153 Accesses	Research article VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG Marcia R Saban, Carole A Davis, Antonio Avelino, Francisco Cruz, Julie Maier, Dale E Bjorling, Thomas J Sferra, Robert E Hurst, Ricardo Saban BMC Physiology 2011, 11:16 (7 November 2011) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Instilling Bacillus Calmette-Guerin into the mouse bladder promotes increased peripheral nerve density mimicked by vascular endothelial growth factor (VEGF) and abolished with neutralizing VEGF antibody, implicating the VEGF pathway as a key modulator of inflammation and nerve plasticity.
	15. 151 Accesses	Research article Endurance training of respiratory muscles improves cycling performance in fit young cyclists Paige Holm, Angela Sattler, Ralph F Fregosi BMC Physiology 2004, 4:9 (6 May 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Experienced cyclists can shave minutes off their race times by regularly putting their respiratory muscles through endurance training, using repetitions of controlled hyperventilation.
	16. 144 Accesses	Research article Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk Karin Arinell, Kjeld Christensen, Stéphane Blanc, Anders Larsson, Ole Fröbert BMC Physiology 2011, 11:17 (9 December 2011) Abstract \| Full text \| PDF \| PubMed
	17. 138 Accesses	Research article Acclimatory responses of the Daphnia pulex proteome to environmental changes. II. Chronic exposure to different temperatures (10 and 20°C) mainly affects protein metabolism Susanne Schwerin, Bettina Zeis, Tobias Lamkemeyer, Rüdiger J Paul, Marita Koch, Johannes Madlung, Claudia Fladerer, Ralph Pirow BMC Physiology 2009, 9:8 (21 April 2009) Abstract \| Full text \| PDF \| PubMed
	18. 131 Accesses	Research article The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes Petra Gran, David Cameron-Smith BMC Physiology 2011, 11:10 (25 June 2011) Abstract \| Full text \| PDF \| PubMed
	19. 129 Accesses	Research article Induction of insulin secretion in engineered liver cells by nitric oxide Latha Muniappan, Sabire Özcan BMC Physiology 2007, 7:11 (17 October 2007) Abstract \| Full text \| PDF \| PubMed
	20. 129 Accesses	Research article Impact of gasoline inhalation on some neurobehavioural characteristics of male rats Amal A Kinawy BMC Physiology 2009, 9:21 (24 November 2009) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Chronic exposure to leaded or unleaded gasoline vapors in male rats impaired the levels of monoamine neurotransmitters in their brain, increased lipid peroxidation and was accompanied with a higher tendency towards aggressive behavior.
	21. 127 Accesses	Methodology article A strategy for determining arterial blood gases on the summit of Mt. Everest Thomas F Catron, Frank L Powell, John B West BMC Physiology 2006, 6:3 (8 March 2006) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Arterial blood sampling at high altitudes, with later testing of blood gases within samples at base stations, is technically feasible, allowing research into the physiological implications of climber exposure to hypoxia.
	22. 125 Accesses	Research article Acclimatory responses of the Daphnia pulex proteome to environmental changes. I. Chronic exposure to hypoxia affects the oxygen transport system and carbohydrate metabolism Bettina Zeis, Tobias Lamkemeyer, Rüdiger J Paul, Frank Nunes, Susanne Schwerin, Marita Koch, Wolfgang Schütz, Johannes Madlung, Claudia Fladerer, Ralph Pirow BMC Physiology 2009, 9:7 (21 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	23. 124 Accesses	Research article Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro Eleni Apostolidou, Efrosyni Paraskeva, Konstantinos Gourgoulianis, Paschalis-Adam Molyvdas, Chrissi Hatzoglou BMC Physiology 2012, 12:2 (16 March 2012) Abstract \| Full text \| PDF \| PubMed
	24. 123 Accesses	Research article The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies Robin A Conwit, Shari Ling, Stephen Roth, Daniel Stashuk, Ben Hurley, Robert Ferrell, E Jeffrey Metter BMC Physiology 2005, 5:15 (23 September 2005) Abstract \| Full text \| PDF \| PubMed
	25. 119 Accesses	Research article Extended flow cytometry characterization of normal bone marrow progenitor cells by simultaneous detection of aldehyde dehydrogenase and early hematopoietic antigens: implication for erythroid differentiation studies Peppino Mirabelli, Rosa Di Noto, Catia Lo Pardo, Paolo Morabito, Giovanna Abate, Marisa Gorrese, Maddalena Raia, Caterina Pascariello, Giulia Scalia, Marica Gemei, Elisabetta Mariotti, Luigi Del Vecchio BMC Physiology 2008, 8:13 (29 May 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central