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1.

536
Accesses

Research article   Open Access Highly Accessed

Disease resistance is related to inherent swimming performance in Atlantic salmon

Vicente Castro, Barbara Grisdale-Helland, Sven M Jørgensen, Jan Helgerud, Guy Claireaux, Anthony P Farrell, Aleksei Krasnov, Ståle J Helland, Harald Takle BMC Physiology 2013, 13:1 (21 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Atlantic salmon that have inherently good swimming performance also show better survival rates when challenged with a viral pathogen, indicating that the swimming trait is associated with disease resistance in fish.

2.

457
Accesses

Research article   Open Access

Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107–Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression

Tohru Saeki, Kosuke Sato, Shiho Ito, Keisuke Ikeda, Ryuhei Kanamoto BMC Physiology 2013, 13:4 (4 February 2013)

Abstract | Full text | PDF | PubMed

3.

395
Accesses

Research article   Open Access Highly Accessed

Transitions into and out of daylight saving time compromise sleep and the rest-activity cycles

Tuuli A Lahti, Sami Leppämäki, Jouko Lönnqvist, Timo Partonen BMC Physiology 2008, 8:3 (12 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

387
Accesses

Research article   Open Access

Quinine controls body weight gain without affecting food intake in male C57BL6 mice

Philippe Cettour-Rose, Carole Bezençon, Christian Darimont, Johannes le Coutre, Sami Damak BMC Physiology 2013, 13:5 (8 February 2013)

Abstract | Full text | PDF | PubMed

5.

337
Accesses

Review   Open Access Highly Accessed

Interleukin-1 beta: a potential link between stress and the development of visceral obesity

Kristin J Speaker, Monika Fleshner BMC Physiology 2012, 12:8 (27 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Kristin Speaker and Monika Fleshner review evidence suggesting that stress-evoked interleukin-1 beta signaling within subcutaneous adipose tissue, when repeatedly induced, contributes toward the development of visceral obesity.

6.

342
Accesses

Methodology article   Open Access Highly Accessed

MicroCT for comparative morphology: simple staining methods allow high-contrast 3D imaging of diverse non-mineralized animal tissues

Brian D Metscher BMC Physiology 2009, 9:11 (22 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

New staining procedures based on inorganic iodine and phosphotungstic acid can be used to produce high-contrast, high-resolution, quantitative 3-D images of soft animal tissues by x-ray microtomography (microCT), opening exciting new opportunities for non-destructive studies of animal morphology.

7.

314
Accesses

Research article   Open Access

The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes

Petra Gran, David Cameron-Smith BMC Physiology 2011, 11:10 (25 June 2011)

Abstract | Full text | PDF | PubMed

8.

299
Accesses

Research article   Open Access

The antioxidant response of the liver of male Swiss mice raised on a AIN 93 or commercial diet

Aline C Caetano, Lucimara F da Veiga, Flávia R Capaldi, Severino M de Alencar, Ricardo A Azevedo, Rosangela MN Bezerra BMC Physiology 2013, 13:3 (24 January 2013)

Abstract | Full text | PDF | PubMed

9.

275
Accesses

Research article   Open Access

Contribution of transient and sustained calcium influx, and sensitization to depolarization-induced contractions of the intact mouse aorta

Paul Fransen, Cor E Van Hove, Johanna van Langen, Dorien M Schrijvers, Wim Martinet, Guido R Y De Meyer, Hidde Bult BMC Physiology 2012, 12:9 (3 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Ca2+ influx affects isometric contraction of mouse aortic segments, with a rapid, transient influx corresponding to transient contraction followed by a second sustained phase of influx and contraction contributing to basal and active tension of aortic smooth muscle.

10.

261
Accesses

Research article   Open Access Highly Accessed

Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue

Olessia Kroupa, Evelina Vorrsjö, Rinke Stienstra, Frits Mattijssen, Stefan K Nilsson, Valentina Sukonina, Sander Kersten, Gunilla Olivecrona, Thomas Olivecrona BMC Physiology 2012, 12:13 (23 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Levels of the lipoprotein lipase (LPL) inhibitor ANGPTL4 respond rapidly to changes in nutritional state of rat adipose tissue, which also alters LPL activity, although this response is blunted in older rats that show signs of insulin resistance.

11.

247
Accesses

Research article   Open Access

Mechanisms of pressure-diuresis and pressure-natriuresis in Dahl salt-resistant and Dahl salt-sensitive rats

Daniel A Beard, Muriel Mescam BMC Physiology 2012, 12:6 (14 May 2012)

Abstract | Full text | PDF | PubMed

12.

246
Accesses

Research article   Open Access Highly Accessed

Endurance training of respiratory muscles improves cycling performance in fit young cyclists

Paige Holm, Angela Sattler, Ralph F Fregosi BMC Physiology 2004, 4:9 (6 May 2004)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Experienced cyclists can shave minutes off their race times by regularly putting their respiratory muscles through endurance training, using repetitions of controlled hyperventilation.

13.

235
Accesses

Research article   Open Access Highly Accessed

Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers

Noel N Kim, Miljan Stankovic, Tulay T Cushman, Irwin Goldstein, Ricardo Munarriz, Abdulmaged M Traish BMC Physiology 2006, 6:4 (30 May 2006)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Induction of diabetes in rats using streptozotocin results in vaginal alterations in histology, blood flow and levels of enzymes controlling genital response, which may explain the decline of sexual function in diabetic women.

14.

227
Accesses

Research article   Open Access Highly Accessed

Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity

Takehiko Oka, Yuhei Nishimura, Liqing Zang, Minoru Hirano, Yasuhito Shimada, Zhipeng Wang, Noriko Umemoto, Junya Kuroyanagi, Norihiro Nishimura, Toshio Tanaka BMC Physiology 2010, 10:21 (21 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A zebrafish model of diet-induced obesity shares common pathophysiological pathways with mammalian obesity, in particular those pathways relating to the blood coagulation cascade and fatty acid metabolism which appear to be conserved in zebrafish and mammals.

15.

209
Accesses

Research article   Open Access

Genomic homeostasis is dysregulated in favour of apoptosis in the colonic epithelium of the azoxymethane treated rat

Caroline A Kerr, Barney M Hines, Janet M Shaw, Robert Dunne, Lauren M Bragg, Julie Clarke, Trevor Lockett, Richard Head BMC Physiology 2013, 13:2 (23 January 2013)

Abstract | Full text | PDF | PubMed

16.

191
Accesses

Research article   Open Access Highly Accessed

Impact of gasoline inhalation on some neurobehavioural characteristics of male rats

Amal A Kinawy BMC Physiology 2009, 9:21 (24 November 2009)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Chronic exposure to leaded or unleaded gasoline vapors in male rats impaired the levels of monoamine neurotransmitters in their brain, increased lipid peroxidation and was accompanied with a higher tendency towards aggressive behavior.

17.

188
Accesses

Research article   Open Access Highly Accessed

Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions

Paul A Watkins, Ann B Moser, Cicely B Toomer, Steven J Steinberg, Hugo W Moser, Mazen W Karaman, Krishna Ramaswamy, Kimberly D Siegmund, D Rick Lee, John J Ely, Oliver A Ryder, Joseph G Hacia BMC Physiology 2010, 10:19 (8 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

18.

185
Accesses

Research article   Open Access Highly Accessed

Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity

Alexandre Dal-Pan, Stéphane Blanc, Fabienne Aujard BMC Physiology 2010, 10:11 (22 June 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The natural plant compound resveratrol reduces the winter body mass gain of gray mouse lemurs by increasing satiety and resting metabolic rate, highlighting the potential effects of this compound on body mass control in primates.

19.

176
Accesses

Research article   Open Access Highly Accessed

Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

Cristi L Galindo, Michael A Skinner, Mounir Errami, L Danielle Olson, David A Watson, Jing Li, John F McCormick, Lauren J McIver, Neil M Kumar, Thinh Q Pham, Harold R Garner BMC Physiology 2009, 9:23 (9 December 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The transcriptional profile of cardiac hypertrophy induced by isoprotenol in mice differs significantly from that induced by exercise while cross-study comparisons reveal close parallels to human ischemia and a 64-gene expression signature shared by all failing hearts.

20.

173
Accesses

Research article   Open Access Highly Accessed

Acclimatory responses of the Daphnia pulex proteome to environmental changes. II. Chronic exposure to different temperatures (10 and 20°C) mainly affects protein metabolism

Susanne Schwerin, Bettina Zeis, Tobias Lamkemeyer, Rüdiger J Paul, Marita Koch, Johannes Madlung, Claudia Fladerer, Ralph Pirow BMC Physiology 2009, 9:8 (21 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

171
Accesses

Research article   Open Access

The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa

Torry A Tucker, James A Fortenberry, Akos Zsembery, Lisa M Schwiebert, Erik M Schwiebert BMC Physiology 2012, 12:12 (24 September 2012)

Abstract | Full text | PDF | PubMed

22.

168
Accesses

Research article   Open Access

Receptors and effects of gut hormones in three osteoblastic cell lines

Elda L Pacheco-Pantoja, Lakshminarayan R Ranganath, James A Gallagher, Peter JM Wilson, William D Fraser BMC Physiology 2011, 11:12 (29 July 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The expression of gut hormone receptors, biochemical bone markers and viability in three osteosarcoma cell lines in response to gut hormones varies depending on the stage of osteoblastic development represented by each cell line.

23.

167
Accesses

Research article   Open Access Highly Accessed

Daily and estrous rhythmicity of body temperature in domestic cattle

Giuseppe Piccione, Giovanni Caola, Roberto Refinetti BMC Physiology 2003, 3:7 (28 July 2003)

Abstract | Full text | PDF | PubMed

24.

166
Accesses

Research article   Open Access

Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency

Rakel Nyrén, Chuchun L Chang, Per Lindström, Anastasia Barmina, Evelina Vorrsjö, Yusuf Ali, Lisa Juntti-Berggren, André Bensadoun, Stephen G Young, Thomas Olivecrona, Gunilla Olivecrona BMC Physiology 2012, 12:14 (27 November 2012)

Abstract | Full text | PDF | PubMed

25.

163
Accesses

Research article   Open Access Highly Accessed

Physiological responses of Daphnia pulex to acid stress

Anna K Weber, Ralph Pirow BMC Physiology 2009, 9:9 (21 April 2009)

Abstract | Full text | PDF | PubMed

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