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VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG
Marcia R Saban, Carole A Davis, Antonio Avelino, Francisco Cruz, Julie Maier, Dale E Bjorling, Thomas J Sferra, Robert E Hurst, Ricardo Saban BMC Physiology 2011, 11:16 (7 November 2011)
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| F1000 Biology
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Editor’s summary
Instilling Bacillus Calmette-Guerin into the mouse bladder promotes increased peripheral nerve density mimicked by vascular endothelial growth factor (VEGF) and abolished with neutralizing VEGF antibody, implicating the VEGF pathway as a key modulator of inflammation and nerve plasticity.
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Calcium sparks in the intact gerbil spiral modiolar artery
Gayathri Krishnamoorthy, Keil Regehr, Samantha Berge, Elias Q Scherer, Philine Wangemann BMC Physiology 2011, 11:15 (26 August 2011)
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Metabolomic phenotyping of a cloned pig model
Morten R Clausen, Kirstine L Christensen, Mette S Hedemann, Ying Liu, Stig Purup, Mette Schmidt, Henrik Callesen, Jan Stagsted, Hanne C Bertram BMC Physiology 2011, 11:14 (22 August 2011)
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Editor’s summary
The metabolite profile of pigs differs between cloned and normal outbred animals, however cloning does not appear to reduce variability as no significant difference in inter-individual variation is seen.
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Monitoring the wild black bear's reaction to human and environmental stressors
Timothy G Laske, David L Garshelis, Paul A Iaizzo BMC Physiology 2011, 11:13 (17 August 2011)
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Yearlong monitoring of the heart rates of wild black bears shows that during hibernation they are ready to respond to danger, and that a female bear returns to hibernation after giving birth to her cubs.
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Receptors and effects of gut hormones in three osteoblastic cell lines
Elda L Pacheco-Pantoja, Lakshminarayan R Ranganath, James A Gallagher, Peter JM Wilson, William D Fraser BMC Physiology 2011, 11:12 (29 July 2011)
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The expression of gut hormone receptors, biochemical bone markers and viability in three osteosarcoma cell lines in response to gut hormones varies depending on the stage of osteoblastic development represented by each cell line.
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Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms
Ana S DePina, Wendy B Iser, Sung-Soo Park, Stuart Maudsley, Mark A Wilson, Catherine A Wolkow BMC Physiology 2011, 11:11 (12 July 2011)
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| F1000 Biology
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Editor’s summary
The daf-2 pathway suppresses vitellogenesis through distinct transcriptional and posttranscriptional mechanisms, revealing that the pleiotropic effects of insulin-like signaling pathway mutations can converge on a common downstream target to modulate longevity.
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The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes
Petra Gran, David Cameron-Smith BMC Physiology 2011, 11:10 (25 June 2011)
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Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms
John H Lillvis, Robert Erdman, Charles M Schworer, Alicia Golden, Kimberly Derr, Zoran Gatalica, Laura A Cox, Jianbin Shen, Richard S Vander Heide, Guy M Lenk, Leigh Hlavaty, Li Li, James R Elmore, David P Franklin, John L Gray, Robert P Garvin, David J Carey, Wayne D Lancaster, Gerard Tromp, Helena Kuivaniemi BMC Physiology 2011, 11:9 (31 May 2011)
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Editor’s summary
HOXA4 is important for maintaining spatial identity in the adult aorta and the down-regulation of HOXA4 gene expression may increase susceptibility to aortic diseases such as abdominal aortic aneurysms (AAAs).
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Non-endothelial endothelin counteracts hypoxic vasodilation in porcine large coronary arteries
Elise R Hedegaard, Edgaras Stankevicius, Ulf Simonsen, Ole Fröbert BMC Physiology 2011, 11:8 (15 May 2011)
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Nitric oxide contributes to hypoxic vasodilation in porcine coronary arteries, probably through K channel opening, which is reversed by addition of endothelin-1 enhanced by endothelin receptor antagonism, indicating that endothelin receptor activation counteracts hypoxic vasodilation.
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Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakness
Chul Kim, Sapeckshita Srivastava, Marian Rice, Tanja A Godenschwege, Brooke Bentley, Saranya Ravi, Shuang Shao, Craig T Woodard, Lawrence M Schwartz BMC Physiology 2011, 11:7 (25 April 2011)
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Ectopic expression of human amyloid precursor protein (hAPP) in fruit flies leads to age- and activity-dependent behavioral defects but does not compromise muscle development or animal longevity.
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JAK/STAT signaling and human in vitro myogenesis
Marissa K Trenerry, Paul Gatta, David Cameron-Smith BMC Physiology 2011, 11:6 (9 March 2011)
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Fatigue-inducing stimulation resolves myotonia in a drug-induced model
Erik van Lunteren, Sarah E Spiegler, Michelle Moyer BMC Physiology 2011, 11:5 (28 February 2011)
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Sodium selectivity of Reissner's membrane epithelial cells
Muneharu Yamazaki, Kyunghee X Kim, Daniel C Marcus BMC Physiology 2011, 11:4 (1 February 2011)
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Editor’s summary
The benzamil-sensitive current in epithelial cells within the Reissner’s membrane of the cochlea is highly selective for Na+ but not K+, suggesting the membrane maintains low Na+ concentration in normal endolymph but is not involved in K+ homeostasis.
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Athletic humans and horses: Comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest
Stefano Capomaccio, Katia Cappelli, Giacomo Spinsanti, Marzia Mencarelli, Michela Muscettola, Michela Felicetti, Andrea Supplizi, Marco Bonifazi BMC Physiology 2011, 11:3 (21 January 2011)
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Study of multiparameter respiratory pattern complexity in surgical critically ill patients during weaning trials
Vasilios E Papaioannou, Ioanna G Chouvarda, Nikos K Maglaveras, Ioannis A Pneumatikos BMC Physiology 2011, 11:2 (21 January 2011)
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Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps
Yong Qi, Kenneth A Longo, Derek J Giuliana, Samantha Gagne, Tom McDonagh, Elizabeth Govek, Anna Nolan, Chaoseng Zou, Kristen Morgan, Jeffrey Hixon, Jeffrey O Saunders, Peter S DiStefano, Brad J Geddes BMC Physiology 2011, 11:1 (6 January 2011)
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Intestinal barrier function of Atlantic salmon (Salmo salar L.) post smolts is reduced by common sea cage environments and suggested as a possible physiological welfare indicator
Henrik Sundh, Bjørn Kvamme, Frode Fridell, Rolf Olsen, Tim Ellis, Geir Taranger, Kristina Sundell BMC Physiology 2010, 10:22 (9 November 2010)
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Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity
Takehiko Oka, Yuhei Nishimura, Liqing Zang, Minoru Hirano, Yasuhito Shimada, Zhipeng Wang, Noriko Umemoto, Junya Kuroyanagi, Norihiro Nishimura, Toshio Tanaka BMC Physiology 2010, 10:21 (21 October 2010)
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Editor’s summary
A zebrafish model of diet-induced obesity shares common pathophysiological pathways with mammalian obesity, in particular those pathways relating to the blood coagulation cascade and fatty acid metabolism which appear to be conserved in zebrafish and mammals.
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Western diet enhances hepatic inflammation in mice exposed to cecal ligation and puncture
Chantal A Rivera, LaTausha Gaskin, Georg Singer, Jeff Houghton, Monique Allman BMC Physiology 2010, 10:20 (19 October 2010)
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Mice fed a high fat western-style diet experience a dramatic immune system overreaction to sepsis, a condition of systemic bacterial infection, due to the toxic effects of excess saturated fats on the liver.
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Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions
Paul A Watkins, Ann B Moser, Cicely B Toomer, Steven J Steinberg, Hugo W Moser, Mazen W Karaman, Krishna Ramaswamy, Kimberly D Siegmund, D Rick Lee, John J Ely, Oliver A Ryder, Joseph G Hacia BMC Physiology 2010, 10:19 (8 October 2010)
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Increased expression and local accumulation of the Prion Protein, Alzheimer Aβ peptides, superoxide dismutase 1, and Nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes
Claudine L Bitel, Yicheng Feng, Nizar Souayah, Peter H Frederikse BMC Physiology 2010, 10:18 (6 September 2010)
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Editor’s summary
Amyloid and oxidative stress-related proteins, often associated with neurodegenerative disorders, also increase in expression and accumulate in the muscle of diabetic rabbits, an observation also seen in muscle diseases associated with different etiologies.
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Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis
Louis Nadeau, Danielle Arbour, Didier Mouginot BMC Physiology 2010, 10:17 (25 August 2010)
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Development of electrocardiogram intervals during growth of FVB/N neonate mice
Christopher R Heier, Thomas G Hampton, Deli Wang, Christine J DiDonato BMC Physiology 2010, 10:16 (24 August 2010)
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Dual role of nNOS in ischemic injury and preconditioning
Anupama Barua, Nicholas B Standen, Manuel Galiñanes BMC Physiology 2010, 10:15 (13 August 2010)
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Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells
Dennis R LaJeunesse, Brooke Johnson, Jason S Presnell, Kathleen Catignas, Grzegorz Zapotoczny BMC Physiology 2010, 10:14 (10 August 2010)
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