Articles

There has been an error retrieving the data. Please try again.
  • Image attributed to: Flickr by Department of Foreign Affairs and Trade

    Safety of tenofovir disoproxil fumarate in combination with emtricitabine (TDF-FTC)

    A pre-exposure trial in African women does not suggest a significant relationship between TDF-FTC and creatinine or phosphorus toxicities, but those randomized to TDF-FTC have higher rates of mild to moderate ALT/AST toxicities, especially those with prior hepatitis B virus exposure.

    BMC Pharmacology and Toxicology 2014, 15:77
  • Image attributed to: BMC Pharmacology and Toxicology 2014, 15:76

    Modeling skin sensitization potential

    The development of a quantum mechanistic model predicts the skin sensitization potential of mechanistically hard-to-be-classified aniline and phenol chemicals and could be useful for the skin sensitization potential predictions of a subset of FDA approved drugs.

    BMC Pharmacology and Toxicology 2014, 15:76
  • Image attributed to: BMC Pharmacology and Toxicology 2014, 15:73

    TXA2R activation does not directly induce cardiomyocyte hypertrophy

    Thromboxane A2 receptor (TXA2R) activation does not induce changes in hypertrophy or genes associated with hypertrophy but is capable of inducing cell death and DNA fragmentation suggesting it may play a role in mediating cell death in cardiomyocytes.

    BMC Pharmacology and Toxicology 2014, 15:73
  • Image attributed to: Flickr by Ed Uthman

    Reducing renal toxicity of cisplatin-based chemotherapy in lung cancer

    Multivariable analysis suggests that high-volume hydration and magnesium supplementation may reduce the renal toxicity induced by cisplatin-based chemotherapy in patients with lung cancer and a low-volume magnesium regimen may be considered for patients with adequate renal function.

    BMC Pharmacology and Toxicology 2014, 15:70
  • Image attributed to: BMC Pharmacology and Toxicology 2014, 15:68

    Substrate specificity and binding of NATs

    Evaluation of the substrate profiles of various native and engineered mammalian arylamine N-acetyltransferases (NATs) in the context of their structures highlights the features which influence substrate selectivity in mammals.

    BMC Pharmacology and Toxicology 2014, 15:68
Submit a manuscript Sign up for article alerts Contact us

Email updates

Receive periodic news and updates relating to BioMed Central .