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  • Supplements

BMC Pharmacology and Toxicology publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 14 Supplement 1

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Erfurt, Germany

28-30 June 2013

Edited by John C Burnett Jr, Franz Hofmann, Kazuwa Nakao, Harald HHW Schmidt and Johannes-Peter Stasch

Publication of this supplement has been fully funded by Bayer Pharma AG. Johannes-Peter Stasch is an employee of Bayer Pharma AG, Wuppertal, Germany. He holds many patents on sGC stimulators and sGC activators. John C Burnett Jr is the chairman of the advisory board for Nile Therapeutics and is a Co-Founder and the Chief Scientific Officer for Zumbro Discovery. Mayo Clinic has licensed CD-NP to Nile Therapeutics and MANP to Zumbro Discovery. The other Supplement Editors declare that they have no competing interests.

Conference website

Oral presentation   Open Access

Chronic natriuretic peptide protein therapeutics

Horng H Chen, Alessandro Cataliotti, John C Burnett BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O1 (29 August 2013)

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Increased nitrosative/oxidative stress lowers myocardial protein kinase G activity in heart failure with preserved ejection fraction

Loek van Heerebeek, Nazha Hamdani, Inês Falcão-Pires, Adelino F Leite-Moreira, Mark PV Begieneman, Jean GF Bronzwaer, Jolanda van der Velden, Ger JM Stienen, Gerrit J Laarman, Aernout Somsen, Freek WA Verheugt, Hans WM Niessen, Walter J Paulus BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O2 (29 August 2013)

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Abstract not submitted for publication

BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O3 (29 August 2013)

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Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application

Kazuwa Nakao, Koitiro Kuwahara, Hiroaki Yasoda, Goro Katuura, Kazuhiro Nakao, Kazumasa Nakao, Yui Yamasita BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O4 (29 August 2013)

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What have genome-wide association studies taught us about cGMP and blood pressure regulation?

Christopher Newton-Cheh BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O5 (29 August 2013)

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Genetic variants in guanylyl cyclase and phoshodiesterase affecting coronary disease risk

Heribert Schunkert BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O6 (29 August 2013)

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Genetic variants of ANP and cardiometabolic protection: from populations to novel therapeutics

Valentina Cannone, Paul M McKie, Angelo Cefalu, Davide Noto, Giovanni Cavera, Michele Pagano, Michelangelo Sapienza, Timothy M Olson, Denise M Heublein, Christopher G Scott, Kent R Bailey, Maurizio Averna, John C Burnett BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O7 (29 August 2013)

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Genetic modifiers of hypertension in sGC-deficient mice

Emmanuel Buys BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O8 (29 August 2013)

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Pulmonary vascular adaptation to high-altitude living

Martin Wilkins BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O9 (29 August 2013)

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MicroRNA miR-425 is a negative regulator of atrial natriuretic peptide

Pankaj Arora, Connie Wu, Donald B Bloch, Brandi N Davis-Dusenbury, Ester Spagnolli, Akiko Hata, Sara Vandenwijngaert, Melissa Swinnen, Stefan Janssens, Emmanuel S Buys, Kenneth D Bloch, Christopher Newton-Cheh, Thomas J Wang BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O10 (29 August 2013)

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cGMP kinase: past, presence and future

Franz Hofmann, Florian Loga, Katrin Domes, Enrico Patrucco, Jörg W Wegener BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O11 (29 August 2013)

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Conformational changes involved in sGC activation

Michael A Marletta, Eric Underbakke, Melody G Campbell, Bridget Carragher, Clinton S Potter BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O12 (29 August 2013)

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A twenty year journey to understand how ATP activates guanylyl cyclase A and B

Lincoln R Potter BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O13 (29 August 2013)

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Soluble guanylate cyclase crystal clear: 1st crystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity

Franziska Seeger, Elsa D Garcin BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O14 (29 August 2013)

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Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site

Opher Gileadi, Charles Allerston, Frank von Delft BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O15 (29 August 2013)

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Structures of human PKG reveal cGMP-selectived activation mechanisms

Gilbert Y Huang, Jeong J Kim, Albert S Reger, Robin Lorenz, Eui-Whan Moon, Chi Zhao, Darren E Casteel, Daniela Bertinetti, Bryan VanSchouwen, Rajeevan Selvaratnam, James W Pflugrath, Banumathi Sankaran, Giuseppe Melacini, Friedrich W Herberg, Choel Kim BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O16 (29 August 2013)

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Targeting native and apo-sGC

Mary Struthers, Subharekha Raghavan, Ronald Kim, Christopher Sinz, Sophie Roy, Michael Mendelsohn BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O17 (29 August 2013)

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Mechanisms driving heme insertion into apo-sGC during its maturation in cells

Dennis Stuehr, Arnab Ghosh, Anindya Sarkar, Yue Dai BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O18 (29 August 2013)

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Redox signalling by protein kinase G Iα in cardiovascular physiology and pathology

Philip Eaton BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O19 (29 August 2013)

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New mechanisms of normoxic and hypoxic cGMP signalling mediated by the nitrite anion

Hunter Champion BMC Pharmacology and Toxicology 2013, 14(Suppl 1):O20 (29 August 2013)

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