BMC Pharmacology and Toxicology | Toxicology section

1.

Translational toxicology: a developmental focus for integrated research strategies

Claude Hughes, Michael Waters, David Allen, Iyabo Obasanjo BMC Pharmacology and Toxicology 2013, 14:51 (30 September 2013)

Abstract | Provisional PDF | Editor’s summary

The integration of exposure assessment, basic toxicology and models to investigate effective interventions that mitigate or reverse adverse effects of environmental exposures may represent an effective portfolio to improve health by minimizing exposure and producing specific therapeutics.

2.

Role of astrocytes in manganese mediated neurotoxicity

Marta Sidoryk-Wegrzynowicz, Michael Aschner BMC Pharmacology and Toxicology 2013, 14:23 (18 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

3.

Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin

Ali S Alfazari, Bayan Al-Dabbagh, Saeeda Almarzooqi, Alia Albawardi, Abdul-Kader Souid BMC Pharmacology and Toxicology 2013, 14:15 (28 February 2013)

Abstract | Full text | PDF | PubMed

4.

3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

Arkadiusz Gertych, Jin Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

3D quantitative DNA methylation imaging enables the quantification of dose-dependent drug-induced spatial progression of DNA demethylation in cell nuclei, independent from interphase cell-cycle stages in conjunction with cytotoxicity.

5.

Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans

Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.

6.

An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology

Lucio G Costa, Michael Aschner BMC Pharmacology and Toxicology 2012, 13:16 (15 November 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Section Editors Lucio G. Costa and Michael Aschner provide their insights on recent developments in the field of toxicology and discuss their future aspirations for BMC Pharmacology and Toxicology.

7.

Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph

Yoshinori Inagaki, Yasuhiko Matsumoto, Keiko Kataoka, Naoya Matsuhashi, Kazuhisa Sekimizu BMC Pharmacology and Toxicology 2012, 13:13 (8 November 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Silkworm larvae may represent a useful model of tissue injury induced by cytotoxic drugs through the measurement of alanine aminotransferase activity and could be useful in evaluating drug toxicity prior to tests in mammals.

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	1.	Debate Translational toxicology: a developmental focus for integrated research strategies Claude Hughes, Michael Waters, David Allen, Iyabo Obasanjo BMC Pharmacology and Toxicology 2013, 14:51 (30 September 2013) Abstract \| Provisional PDF \| Editor’s summary The integration of exposure assessment, basic toxicology and models to investigate effective interventions that mitigate or reverse adverse effects of environmental exposures may represent an effective portfolio to improve health by minimizing exposure and producing specific therapeutics.
	2.	Review Role of astrocytes in manganese mediated neurotoxicity Marta Sidoryk-Wegrzynowicz, Michael Aschner BMC Pharmacology and Toxicology 2013, 14:23 (18 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	3.	Research article Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin Ali S Alfazari, Bayan Al-Dabbagh, Saeeda Almarzooqi, Alia Albawardi, Abdul-Kader Souid BMC Pharmacology and Toxicology 2013, 14:15 (28 February 2013) Abstract \| Full text \| PDF \| PubMed
	4.	Research article 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models Arkadiusz Gertych, Jin Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary 3D quantitative DNA methylation imaging enables the quantification of dose-dependent drug-induced spatial progression of DNA demethylation in cell nuclei, independent from interphase cell-cycle stages in conjunction with cytotoxicity.
	5.	Research article Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.
	6.	Editorial An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology Lucio G Costa, Michael Aschner BMC Pharmacology and Toxicology 2012, 13:16 (15 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Section Editors Lucio G. Costa and Michael Aschner provide their insights on recent developments in the field of toxicology and discuss their future aspirations for BMC Pharmacology and Toxicology.
	7.	Research article Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph Yoshinori Inagaki, Yasuhiko Matsumoto, Keiko Kataoka, Naoya Matsuhashi, Kazuhisa Sekimizu BMC Pharmacology and Toxicology 2012, 13:13 (8 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Silkworm larvae may represent a useful model of tissue injury induced by cytotoxic drugs through the measurement of alanine aminotransferase activity and could be useful in evaluating drug toxicity prior to tests in mammals.