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Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats
Nagesh Gowda, Anilkumar Dandu, Jaideep Singh, Sanghamitra Biswas, Vijaya Raghav, Mudigere N Lakshmi, Pavagada C Shilpa, Venkategowda Sunil, Ashokkumar Reddy, Manojkumar Sadasivuni, Kumaraswamy Aparna, Mahesh Verma, Yoganand Moolemath, Mammen O Anup, Marikunte V Venkataranganna, Baggavalli P Somesh, Madanahalli R Jagannath BMC Pharmacology and Toxicology 2013, 14:28 (21 May 2013)
Abstract | Full text | PDF
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Editor’s summary
Rats treated with CNX-011-67 demonstrate improved glucose mediated insulin secretion and insulin gene transcription, enhanced glucose oxidation in the form of increased islet ATP content and overall improvement in beta cell health.
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