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1.
The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells
R Preston Mason, Robert F Jacob, J Jose Corbalan, Damian Szczesny, Kinga Matysiak, Tadeusz Malinski BMC Pharmacology and Toxicology 2013, 14 :48 (28 September 2013)
Abstract | Provisional PDF
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Editor’s summary
The ability of nebivolol to stimulate nitric oxide release appears to be independent of its selective beta1-adrenoceptor blockade properties and dependent on stimulation of beta3-adrenoceptors and ATP-mediated stimulation of P2Y-purinergic receptors in human endothelial cells.
2.
Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
Maria Luisa Dupuis, Alessandro Ascione, Lucia Palmisano, Stefano Vella, Maurizio Cianfriglia BMC Pharmacology and Toxicology 2013, 14 :47 (20 September 2013)
Abstract | Provisional PDF
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3.
Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning
Ahmed E Enayetallah, Dinesh Puppala, Daniel Ziemek, James E Fischer, Sheila Kantesaria, Mathew T Pletcher BMC Pharmacology and Toxicology 2013, 14 :46 (6 September 2013)
Abstract | Full text | PDF
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4.
An interview with David H Farb, Section Editor for Basic Pharmacology
David H Farb BMC Pharmacology and Toxicology 2013, 14 :42 (30 August 2013)
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Editor’s summary
Section Editor David Farb provides his insights on recent developments in the field of pharmacology and discusses his future aspirations for BMC Pharmacology and Toxicology.
5.
Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity
Shamol Saha, Yinghui Hu, Stella C Martin, Sabita Bandyopadhyay, Shelley J Russek, David H Farb BMC Pharmacology and Toxicology 2013, 14 :37 (23 July 2013)
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Editor’s summary
Polycomblike protein PHF1b stimulates GABRB1 promoter activity in primary cultured neurons and chronic GABA exposure regulates PHF1 binding to endogenous Gabrb1 indicating its role as a molecular transducer of GABA-mediated neurotransmission.
6.
Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
Shu Liu, David Hsieh, Yi-Lin Yang, Zhidong Xu, Csaba Peto, David M Jablons, Liang You BMC Pharmacology and Toxicology 2013, 14 :36 (11 July 2013)
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Editor’s summary
Cell-free, in vitro and molecular docking studies indicate that the phytoestrogen coumestrol is a novel ATP competitive and cell permeable Casein kinase 2 (CK2) inhibitor with a submicromolar IC50 .
7.
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
Therese Bredholt, Elisabeth Ersvær, Bjarte Erikstein, André Sulen, Håkon Reikvam, Hans Aarstad, Anne Johannessen, Olav Vintermyr, Øystein Bruserud, Bjørn Gjertsen BMC Pharmacology and Toxicology 2013, 14 :35 (11 July 2013)
Abstract | Full text | PDF
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8.
Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
Monica Pallis, Francis Burrows, Abigail Whittall, Nicholas Boddy, Claire Seedhouse, Nigel Russell BMC Pharmacology and Toxicology 2013, 14 :32 (15 June 2013)
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9.
Anvirzel™ in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines
Panagiotis Apostolou, Maria Toloudi, Marina Chatziioannou, Eleni Ioannou, Dennis R Knocke, Joe Nester, Dimitrios Komiotis, Ioannis Papasotiriou BMC Pharmacology and Toxicology 2013, 14 :18 (25 March 2013)
Abstract | Full text | PDF
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10.
R- and S-Equol have equivalent cytoprotective effects in Friedreich’s Ataxia
Timothy E Richardson, James W Simpkins BMC Pharmacology and Toxicology 2012, 13 :12 (22 October 2012)
Abstract | Full text | PDF
| PubMed
