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1.
5176 Accesses
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Intrathecal baclofen withdrawal syndrome- a life-threatening complication of baclofen pump: A case report
Imran Mohammed, Asif Hussain BMC Clinical Pharmacology 2004, 4:6 (9 August 2004)
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2.
1652 Accesses
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Hit identification of IKKβ natural product inhibitor
Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma BMC Pharmacology and Toxicology 2013, 14:3 (7 January 2013)
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3.
993 Accesses
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Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units
Maria Gustafsson, Stig Karlsson, Hugo Lövheim BMC Pharmacology and Toxicology 2013, 14:10 (8 February 2013)
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4.
790 Accesses
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Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people
MRC/BHF Heart Protection Study Collaborative Group BMC Clinical Pharmacology 2009, 9:6 (31 March 2009)
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Editor’s summary
Simvastatin treatment for patients at high risk of cardiovascular events or with diabetes results in only a minor increase in the risk of myopathy and hepatobiliary diseases over 5 years of use.
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5.
764 Accesses
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3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models
Arkadiusz Gertych, Jin Ho Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013)
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6.
587 Accesses
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Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results
James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet, Jane El-Dahr BMC Clinical Pharmacology 2009, 9:16 (23 October 2009)
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| PubMed | Cited on BioMed Central
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7.
550 Accesses
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Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study
Ronald G Hall, Kathleen A Hazlewood, Sara D Brouse, Christopher A Giuliano, Krystal K Haase, Chistopher R Frei, Nicolas A Forcade, Todd Bell, Roger J Bedimo, Carlos A Alvarez BMC Pharmacology and Toxicology 2013, 14:12 (13 February 2013)
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8.
532 Accesses
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Finasteride induced depression: a prospective study
Babak Rahimi-Ardabili, Ramin Pourandarjani, Peiman Habibollahi, Amir Mualeki BMC Clinical Pharmacology 2006, 6:7 (7 October 2006)
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9.
487 Accesses
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A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study
Suzanne Dunne, Bill Shannon, Colum Dunne, Walter Cullen BMC Pharmacology and Toxicology 2013, 14:1 (5 January 2013)
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10.
467 Accesses
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Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans
Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013)
Abstract | Provisional PDF
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Editor’s summary
Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.
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11.
398 Accesses
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Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
Simon K Mencher, Long G Wang BMC Clinical Pharmacology 2005, 5:3 (26 April 2005)
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Editor’s summary
Truly selective drugs may be less desirable than more 'promiscuous' drugs which correct the imbalance of several molecules involved in a disease process; this viewpoint has implications for current research trends focused on drug selectivity.
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12.
392 Accesses
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Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers
Peter M Dewland, Sandie Reader, Phillip Berry BMC Clinical Pharmacology 2009, 9:19 (4 December 2009)
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Editor’s summary
The time to maximum blood concentration of ibuprofen is cut from 90 minutes to just 35 minutes if ibuprofen sodium dihydrate is taken rather than the standard formulation, but adding poloxamer makes no significant difference to bioavailability.
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13.
374 Accesses
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Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide
Vincenzo Lariccia, Alessandra Moraca, Marco Marini, Annamaria Assunta Nasti, Ilaria Battistoni, Salvatore Amoroso, Gian Piero Perna BMC Pharmacology and Toxicology 2013, 14:8 (24 January 2013)
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14.
365 Accesses
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In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice
Kathryn A Ramsey, Alexander N Larcombe, Peter D Sly, Graeme R Zosky BMC Pharmacology and Toxicology 2013, 14:13 (18 February 2013)
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15.
354 Accesses
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Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points
Jessica Stahl, Mareike Wohlert, Manfred Kietzmann BMC Pharmacology and Toxicology 2012, 13:5 (13 August 2012)
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Editor’s summary
Microneedle rollers enhance the delivery of topically applied non-steroidal anti-inflammatory drugs and represent a valuable tool for percutaneous permeation enhancement, particularly for hydrophilic substances or those with high melting points.
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16.
349 Accesses
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The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903]
Edward Mills, Jonathan Prousky, Gannady Raskin, Joel Gagnier, Beth Rachlis, Victor M Montori, David Juurlink BMC Clinical Pharmacology 2003, 3:4 (13 November 2003)
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17.
344 Accesses
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Adherence to medication for the treatment of psychosis: rates and risk factors in an Ethiopian population
Menna Alene, Michael D Wiese, Mulugeta T Angamo, Beata V Bajorek, Elias A Yesuf, Nasir Wabe BMC Clinical Pharmacology 2012, 12:10 (18 June 2012)
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18.
342 Accesses
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Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil
Márcia Germana Alves de Araújo Lobo, Sandra Maria Botelho Pinheiro, José Gerley Díaz Castro, Valéria Gomes Momenté, Maria-Cristina S Pranchevicius BMC Pharmacology and Toxicology 2013, 14:5 (8 January 2013)
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19.
320 Accesses
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Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics
Andres F Zuluaga, Maria Agudelo, Carlos A Rodriguez, Omar Vesga BMC Clinical Pharmacology 2009, 9:1 (16 January 2009)
Abstract | Full text | PDF
| PubMed | Cited on BioMed Central
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Editor’s summary
Pharmaceutical equivalence of generic intravenous antibiotics can be assessed prior to their clinical use by providing information about potency and efficacy using a new microbiological assay with reference bacteria
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20.
318 Accesses
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Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231
Mariel Núñez, Vanina Medina, Graciela Cricco, Máximo Croci, Claudia Cocca, Elena Rivera, Rosa Bergoc, Gabriela Martín BMC Pharmacology and Toxicology 2013, 14:6 (11 January 2013)
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21.
313 Accesses
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Errors in medication history at hospital admission: prevalence and predicting factors
Lina M Hellström, Åsa Bondesson, Peter Höglund, Tommy Eriksson BMC Clinical Pharmacology 2012, 12:9 (3 April 2012)
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22.
283 Accesses
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Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis - An open clinical trial-
Kenji Kumagai, Susumu Shirabe, Noriaki Miyata, Masakazu Murata, Atsushi Yamauchi, Yasuhumi Kataoka, Masami Niwa BMC Clinical Pharmacology 2010, 10:7 (28 March 2010)
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23.
275 Accesses
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Systematic review of dexketoprofen in acute and chronic pain
R Andrew Moore, Jodie Barden BMC Clinical Pharmacology 2008, 8:11 (31 October 2008)
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24.
269 Accesses
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Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
Howard A Smithline, Michael Donnino, David J Greenblatt BMC Clinical Pharmacology 2012, 12:4 (4 February 2012)
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25.
247 Accesses
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The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol
Trevor Tanner, Sue Aspley, Andrew Munn, Tracy Thomas BMC Clinical Pharmacology 2010, 10:10 (5 July 2010)
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Editor’s summary
Paracetemol is absorbed significantly faster when taken in a combination dose with ibuprofen compared to when taken in isolation, with greater blood plasma concentrations of both being reached earlier, offering potentially enhanced pain relief.
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