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1.

5176
Accesses

Case report   Open Access Highly Accessed

Intrathecal baclofen withdrawal syndrome- a life-threatening complication of baclofen pump: A case report

Imran Mohammed, Asif Hussain BMC Clinical Pharmacology 2004, 4:6 (9 August 2004)

Abstract | Full text | PDF | PubMed

2.

1652
Accesses

Research article   Open Access Highly Accessed

Hit identification of IKKβ natural product inhibitor

Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma BMC Pharmacology and Toxicology 2013, 14:3 (7 January 2013)

Abstract | Full text | PDF | PubMed

3.

993
Accesses

Research article   Open Access

Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units

Maria Gustafsson, Stig Karlsson, Hugo Lövheim BMC Pharmacology and Toxicology 2013, 14:10 (8 February 2013)

Abstract | Full text | PDF | PubMed

4.

790
Accesses

Research article   Open Access Highly Accessed

Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people

MRC/BHF Heart Protection Study Collaborative Group BMC Clinical Pharmacology 2009, 9:6 (31 March 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Simvastatin treatment for patients at high risk of cardiovascular events or with diabetes results in only a minor increase in the risk of myopathy and hepatobiliary diseases over 5 years of use.

5.

764
Accesses

Research article   Open Access

3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

Arkadiusz Gertych, Jin Ho Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013)

Abstract | Provisional PDF | PubMed

6.

587
Accesses

Research article   Open Access Highly Accessed

Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results

James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet, Jane El-Dahr BMC Clinical Pharmacology 2009, 9:16 (23 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

550
Accesses

Research article   Open Access

Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study

Ronald G Hall, Kathleen A Hazlewood, Sara D Brouse, Christopher A Giuliano, Krystal K Haase, Chistopher R Frei, Nicolas A Forcade, Todd Bell, Roger J Bedimo, Carlos A Alvarez BMC Pharmacology and Toxicology 2013, 14:12 (13 February 2013)

Abstract | Full text | PDF | PubMed

8.

532
Accesses

Research article   Open Access Highly Accessed

Finasteride induced depression: a prospective study

Babak Rahimi-Ardabili, Ramin Pourandarjani, Peiman Habibollahi, Amir Mualeki BMC Clinical Pharmacology 2006, 6:7 (7 October 2006)

Abstract | Full text | PDF | PubMed | 1 comment

9.

487
Accesses

Review   Open Access

A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study

Suzanne Dunne, Bill Shannon, Colum Dunne, Walter Cullen BMC Pharmacology and Toxicology 2013, 14:1 (5 January 2013)

Abstract | Full text | PDF | PubMed

10.

467
Accesses

Research article   Open Access

Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans

Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.

11.

398
Accesses

Debate   Open Access Highly Accessed

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

Simon K Mencher, Long G Wang BMC Clinical Pharmacology 2005, 5:3 (26 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Truly selective drugs may be less desirable than more 'promiscuous' drugs which correct the imbalance of several molecules involved in a disease process; this viewpoint has implications for current research trends focused on drug selectivity.

12.

392
Accesses

Research article   Open Access Highly Accessed

Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers

Peter M Dewland, Sandie Reader, Phillip Berry BMC Clinical Pharmacology 2009, 9:19 (4 December 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The time to maximum blood concentration of ibuprofen is cut from 90 minutes to just 35 minutes if ibuprofen sodium dihydrate is taken rather than the standard formulation, but adding poloxamer makes no significant difference to bioavailability.

13.

374
Accesses

Case report   Open Access

Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide

Vincenzo Lariccia, Alessandra Moraca, Marco Marini, Annamaria Assunta Nasti, Ilaria Battistoni, Salvatore Amoroso, Gian Piero Perna BMC Pharmacology and Toxicology 2013, 14:8 (24 January 2013)

Abstract | Full text | PDF | PubMed

14.

365
Accesses

Research article   Open Access

In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice

Kathryn A Ramsey, Alexander N Larcombe, Peter D Sly, Graeme R Zosky BMC Pharmacology and Toxicology 2013, 14:13 (18 February 2013)

Abstract | Full text | PDF | PubMed

15.

354
Accesses

Research article   Open Access

Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points

Jessica Stahl, Mareike Wohlert, Manfred Kietzmann BMC Pharmacology and Toxicology 2012, 13:5 (13 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Microneedle rollers enhance the delivery of topically applied non-steroidal anti-inflammatory drugs and represent a valuable tool for percutaneous permeation enhancement, particularly for hydrophilic substances or those with high melting points.

16.

349
Accesses

Research article   Open Access Highly Accessed

The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903]

Edward Mills, Jonathan Prousky, Gannady Raskin, Joel Gagnier, Beth Rachlis, Victor M Montori, David Juurlink BMC Clinical Pharmacology 2003, 3:4 (13 November 2003)

Abstract | Full text | PDF | PubMed

17.

344
Accesses

Research article   Open Access

Adherence to medication for the treatment of psychosis: rates and risk factors in an Ethiopian population

Menna Alene, Michael D Wiese, Mulugeta T Angamo, Beata V Bajorek, Elias A Yesuf, Nasir Wabe BMC Clinical Pharmacology 2012, 12:10 (18 June 2012)

Abstract | Full text | PDF | PubMed

18.

342
Accesses

Research article   Open Access

Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil

Márcia Germana Alves de Araújo Lobo, Sandra Maria Botelho Pinheiro, José Gerley Díaz Castro, Valéria Gomes Momenté, Maria-Cristina S Pranchevicius BMC Pharmacology and Toxicology 2013, 14:5 (8 January 2013)

Abstract | Full text | PDF | PubMed

19.

320
Accesses

Research article   Open Access Highly Accessed

Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics

Andres F Zuluaga, Maria Agudelo, Carlos A Rodriguez, Omar Vesga BMC Clinical Pharmacology 2009, 9:1 (16 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Pharmaceutical equivalence of generic intravenous antibiotics can be assessed prior to their clinical use by providing information about potency and efficacy using a new microbiological assay with reference bacteria

20.

318
Accesses

Research article   Open Access

Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231

Mariel Núñez, Vanina Medina, Graciela Cricco, Máximo Croci, Claudia Cocca, Elena Rivera, Rosa Bergoc, Gabriela Martín BMC Pharmacology and Toxicology 2013, 14:6 (11 January 2013)

Abstract | Full text | PDF | PubMed

21.

313
Accesses

Research article   Open Access

Errors in medication history at hospital admission: prevalence and predicting factors

Lina M Hellström, Åsa Bondesson, Peter Höglund, Tommy Eriksson BMC Clinical Pharmacology 2012, 12:9 (3 April 2012)

Abstract | Full text | PDF | PubMed

22.

283
Accesses

Research article   Open Access Highly Accessed

Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis - An open clinical trial-

Kenji Kumagai, Susumu Shirabe, Noriaki Miyata, Masakazu Murata, Atsushi Yamauchi, Yasuhumi Kataoka, Masami Niwa BMC Clinical Pharmacology 2010, 10:7 (28 March 2010)

Abstract | Full text | PDF | PubMed

23.

275
Accesses

Research article   Open Access

Systematic review of dexketoprofen in acute and chronic pain

R Andrew Moore, Jodie Barden BMC Clinical Pharmacology 2008, 8:11 (31 October 2008)

Abstract | Full text | PDF | PubMed

24.

269
Accesses

Research article   Open Access

Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

Howard A Smithline, Michael Donnino, David J Greenblatt BMC Clinical Pharmacology 2012, 12:4 (4 February 2012)

Abstract | Full text | PDF | PubMed

25.

247
Accesses

Research article   Open Access Highly Accessed

The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol

Trevor Tanner, Sue Aspley, Andrew Munn, Tracy Thomas BMC Clinical Pharmacology 2010, 10:10 (5 July 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Paracetemol is absorbed significantly faster when taken in a combination dose with ibuprofen compared to when taken in isolation, with greater blood plasma concentrations of both being reached earlier, offering potentially enhanced pain relief.

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