BMC Pharmacology and Toxicology

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		Research article Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin Ali S Alfazari, Bayan Al-Dabbagh, Saeeda Almarzooqi, Alia Albawardi, Abdul-Kader Souid BMC Pharmacology and Toxicology 2013, 14:15 (28 February 2013) Abstract \| Provisional PDF
		Research article Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study Anthony Cahn, Simon Hodgson, Robert Wilson, Jonathan Robertson, Joanna Watson, Misba Beerahee, Steve C Hughes, Graeme Young, Rebecca Graves, David Hall, Sjoerd van Marle, Roberto Solari BMC Pharmacology and Toxicology 2013, 14:14 (28 February 2013) Abstract \| Provisional PDF
		Research article In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice Kathryn A Ramsey, Alexander N Larcombe, Peter D Sly, Graeme R Zosky BMC Pharmacology and Toxicology 2013, 14:13 (18 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study Ronald G Hall, Kathleen A Hazlewood, Sara D Brouse, Christopher A Giuliano, Krystal K Haase, Chistopher R Frei, Nicolas A Forcade, Todd Bell, Roger J Bedimo, Carlos A Alvarez BMC Pharmacology and Toxicology 2013, 14:12 (13 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models Arkadiusz Gertych, Jin Ho Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013) Abstract \| Provisional PDF \| PubMed
		Research article Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units Maria Gustafsson, Stig Karlsson, Hugo Lövheim BMC Pharmacology and Toxicology 2013, 14:10 (8 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.
		Case report Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide Vincenzo Lariccia, Alessandra Moraca, Marco Marini, Annamaria Assunta Nasti, Ilaria Battistoni, Salvatore Amoroso, Gian Piero Perna BMC Pharmacology and Toxicology 2013, 14:8 (24 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate Mohamed A Ibrahim, Diana V Do, Yasir J Sepah, Syed M Shah, Elizabeth Van Anden, Gulnar Hafiz, J Kevin Donahue, Richard Rivers, Jai Balkissoon, James T Handa, Peter A Campochiaro, Quan Dong Nguyen BMC Pharmacology and Toxicology 2013, 14:7 (14 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231 Mariel Núñez, Vanina Medina, Graciela Cricco, Máximo Croci, Claudia Cocca, Elena Rivera, Rosa Bergoc, Gabriela Martín BMC Pharmacology and Toxicology 2013, 14:6 (11 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil Márcia Germana Alves de Araújo Lobo, Sandra Maria Botelho Pinheiro, José Gerley Díaz Castro, Valéria Gomes Momenté, Maria-Cristina S Pranchevicius BMC Pharmacology and Toxicology 2013, 14:5 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Allosteric transition. A comparison of two models Niels Bindslev BMC Pharmacology and Toxicology 2013, 14:4 (8 January 2013) Abstract \| Provisional PDF \| PubMed
		Research article Hit identification of IKKβ natural product inhibitor Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma BMC Pharmacology and Toxicology 2013, 14:3 (7 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats Rafael Bonfante-Cabarcas, Erlymar López Hincapié, Eliezer Jiménez Hernández, Ruth Fonseca Zambrano, Lady Ferrer Mancini, Marcos Durand Mena, Claudina Rodríguez-Bonfante BMC Pharmacology and Toxicology 2013, 14:2 (7 January 2013) Abstract \| Full text \| PDF \| PubMed
		Review A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study Suzanne Dunne, Bill Shannon, Colum Dunne, Walter Cullen BMC Pharmacology and Toxicology 2013, 14:1 (5 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG(R)) in patients with mycosis fungoides: an open-label trial Yanelda García-Vega, Idrian García-García, Sonia E Collazo-Caballero, Egla E Santely-Pravia, Alieski Cruz-Ramírez, Ángela D Tuero-Iglesias, Cristian Alfonso-Alvarado, Mileidys Cabrera-Placeres, Nailet Castro-Basart, Yaquelín Duncan-Roberts, Tania I Carballo-Treto, Josanne Soto-Matos, Yoandy Izquierdo-Toledo, Dania Vázquez-Blomquist, Elizeth García-Iglesias, Iraldo Bello-Rivero BMC Pharmacology and Toxicology 2012, 13:20 (28 December 2012) Abstract \| Provisional PDF \| PubMed
		Research article Experiences from consumer reports on psychiatric adverse drug reactions with antidepressant medication: a qualitative study of reports to a consumer association Andreas Vilhelmsson, Tommy Svensson, Anna Meeuwisse, Anders Carlsten BMC Pharmacology and Toxicology 2012, 13:19 (23 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Efficacy of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder previously treated with amphetamines: analyses from a randomized, double-blind, multicenter, placebo-controlled titration study Thomas Babcock, Bryan Dirks, Ben Adeyi, Brian Scheckner BMC Pharmacology and Toxicology 2012, 13:18 (19 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats Oluseyi C Ayinde, Sunday Ogunnowo, Rita A Ogedegbe BMC Pharmacology and Toxicology 2012, 13:17 (14 December 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology Lucio G Costa, Michael Aschner BMC Pharmacology and Toxicology 2012, 13:16 (15 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Section Editors Lucio G. Costa and Michael Aschner provide their insights on recent developments in the field of toxicology and discuss their future aspirations for BMC Pharmacology and Toxicology.
		Research article Comparison of the anti-inflammatory effects of Cilomilast, Budesonide and a p38 Mitogen activated protein kinase inhibitor in COPD lung tissue macrophages Marianne Jennifer Ratcliffe, Iain Gordon Dougall BMC Pharmacology and Toxicology 2012, 13:15 (13 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article An open prospective study of amikacin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration Deirdre M D’Arcy, Eoin Casey, Caitriona M Gowing, Maria B Donnelly, Owen I Corrigan BMC Pharmacology and Toxicology 2012, 13:14 (8 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph Yoshinori Inagaki, Yasuhiko Matsumoto, Keiko Kataoka, Naoya Matsuhashi, Kazuhisa Sekimizu BMC Pharmacology and Toxicology 2012, 13:13 (8 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Silkworm larvae may represent a useful model of tissue injury induced by cytotoxic drugs through the measurement of alanine aminotransferase activity and could be useful in evaluating drug toxicity prior to tests in mammals.
		Research article R- and S-Equol have equivalent cytoprotective effects in Friedreich’s Ataxia Timothy E Richardson, James W Simpkins BMC Pharmacology and Toxicology 2012, 13:12 (22 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells Warren Winick-Ng, Francesco Leri, Bettina E Kalisch BMC Pharmacology and Toxicology 2012, 13:11 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nitric oxide and histone deacetylase activity regulate cocaine-induced Mu-opioid receptor (MOR) expression at both transcriptional and post-transcriptional levels in PC12 cells, suggesting that epigenetic mechanisms modulate cocaine's action on MOR expression in vivo.

	All
		Research article Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin Ali S Alfazari, Bayan Al-Dabbagh, Saeeda Almarzooqi, Alia Albawardi, Abdul-Kader Souid BMC Pharmacology and Toxicology 2013, 14:15 (28 February 2013) Abstract \| Provisional PDF
		Research article Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study Anthony Cahn, Simon Hodgson, Robert Wilson, Jonathan Robertson, Joanna Watson, Misba Beerahee, Steve C Hughes, Graeme Young, Rebecca Graves, David Hall, Sjoerd van Marle, Roberto Solari BMC Pharmacology and Toxicology 2013, 14:14 (28 February 2013) Abstract \| Provisional PDF
		Research article In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice Kathryn A Ramsey, Alexander N Larcombe, Peter D Sly, Graeme R Zosky BMC Pharmacology and Toxicology 2013, 14:13 (18 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study Ronald G Hall, Kathleen A Hazlewood, Sara D Brouse, Christopher A Giuliano, Krystal K Haase, Chistopher R Frei, Nicolas A Forcade, Todd Bell, Roger J Bedimo, Carlos A Alvarez BMC Pharmacology and Toxicology 2013, 14:12 (13 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models Arkadiusz Gertych, Jin Ho Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013) Abstract \| Provisional PDF \| PubMed
		Research article Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units Maria Gustafsson, Stig Karlsson, Hugo Lövheim BMC Pharmacology and Toxicology 2013, 14:10 (8 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.
		Case report Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide Vincenzo Lariccia, Alessandra Moraca, Marco Marini, Annamaria Assunta Nasti, Ilaria Battistoni, Salvatore Amoroso, Gian Piero Perna BMC Pharmacology and Toxicology 2013, 14:8 (24 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate Mohamed A Ibrahim, Diana V Do, Yasir J Sepah, Syed M Shah, Elizabeth Van Anden, Gulnar Hafiz, J Kevin Donahue, Richard Rivers, Jai Balkissoon, James T Handa, Peter A Campochiaro, Quan Dong Nguyen BMC Pharmacology and Toxicology 2013, 14:7 (14 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231 Mariel Núñez, Vanina Medina, Graciela Cricco, Máximo Croci, Claudia Cocca, Elena Rivera, Rosa Bergoc, Gabriela Martín BMC Pharmacology and Toxicology 2013, 14:6 (11 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil Márcia Germana Alves de Araújo Lobo, Sandra Maria Botelho Pinheiro, José Gerley Díaz Castro, Valéria Gomes Momenté, Maria-Cristina S Pranchevicius BMC Pharmacology and Toxicology 2013, 14:5 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Allosteric transition. A comparison of two models Niels Bindslev BMC Pharmacology and Toxicology 2013, 14:4 (8 January 2013) Abstract \| Provisional PDF \| PubMed
		Research article Hit identification of IKKβ natural product inhibitor Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma BMC Pharmacology and Toxicology 2013, 14:3 (7 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats Rafael Bonfante-Cabarcas, Erlymar López Hincapié, Eliezer Jiménez Hernández, Ruth Fonseca Zambrano, Lady Ferrer Mancini, Marcos Durand Mena, Claudina Rodríguez-Bonfante BMC Pharmacology and Toxicology 2013, 14:2 (7 January 2013) Abstract \| Full text \| PDF \| PubMed
		Review A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study Suzanne Dunne, Bill Shannon, Colum Dunne, Walter Cullen BMC Pharmacology and Toxicology 2013, 14:1 (5 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG(R)) in patients with mycosis fungoides: an open-label trial Yanelda García-Vega, Idrian García-García, Sonia E Collazo-Caballero, Egla E Santely-Pravia, Alieski Cruz-Ramírez, Ángela D Tuero-Iglesias, Cristian Alfonso-Alvarado, Mileidys Cabrera-Placeres, Nailet Castro-Basart, Yaquelín Duncan-Roberts, Tania I Carballo-Treto, Josanne Soto-Matos, Yoandy Izquierdo-Toledo, Dania Vázquez-Blomquist, Elizeth García-Iglesias, Iraldo Bello-Rivero BMC Pharmacology and Toxicology 2012, 13:20 (28 December 2012) Abstract \| Provisional PDF \| PubMed
		Research article Experiences from consumer reports on psychiatric adverse drug reactions with antidepressant medication: a qualitative study of reports to a consumer association Andreas Vilhelmsson, Tommy Svensson, Anna Meeuwisse, Anders Carlsten BMC Pharmacology and Toxicology 2012, 13:19 (23 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Efficacy of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder previously treated with amphetamines: analyses from a randomized, double-blind, multicenter, placebo-controlled titration study Thomas Babcock, Bryan Dirks, Ben Adeyi, Brian Scheckner BMC Pharmacology and Toxicology 2012, 13:18 (19 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats Oluseyi C Ayinde, Sunday Ogunnowo, Rita A Ogedegbe BMC Pharmacology and Toxicology 2012, 13:17 (14 December 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology Lucio G Costa, Michael Aschner BMC Pharmacology and Toxicology 2012, 13:16 (15 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Section Editors Lucio G. Costa and Michael Aschner provide their insights on recent developments in the field of toxicology and discuss their future aspirations for BMC Pharmacology and Toxicology.
		Research article Comparison of the anti-inflammatory effects of Cilomilast, Budesonide and a p38 Mitogen activated protein kinase inhibitor in COPD lung tissue macrophages Marianne Jennifer Ratcliffe, Iain Gordon Dougall BMC Pharmacology and Toxicology 2012, 13:15 (13 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article An open prospective study of amikacin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration Deirdre M D’Arcy, Eoin Casey, Caitriona M Gowing, Maria B Donnelly, Owen I Corrigan BMC Pharmacology and Toxicology 2012, 13:14 (8 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph Yoshinori Inagaki, Yasuhiko Matsumoto, Keiko Kataoka, Naoya Matsuhashi, Kazuhisa Sekimizu BMC Pharmacology and Toxicology 2012, 13:13 (8 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Silkworm larvae may represent a useful model of tissue injury induced by cytotoxic drugs through the measurement of alanine aminotransferase activity and could be useful in evaluating drug toxicity prior to tests in mammals.
		Research article R- and S-Equol have equivalent cytoprotective effects in Friedreich’s Ataxia Timothy E Richardson, James W Simpkins BMC Pharmacology and Toxicology 2012, 13:12 (22 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells Warren Winick-Ng, Francesco Leri, Bettina E Kalisch BMC Pharmacology and Toxicology 2012, 13:11 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nitric oxide and histone deacetylase activity regulate cocaine-induced Mu-opioid receptor (MOR) expression at both transcriptional and post-transcriptional levels in PC12 cells, suggesting that epigenetic mechanisms modulate cocaine's action on MOR expression in vivo.