BMC Pharmacology and Toxicology

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		Debate Translational toxicology: a developmental focus for integrated research strategies Claude Hughes, Michael Waters, David Allen, Iyabo Obasanjo BMC Pharmacology and Toxicology 2013, 14:51 (30 September 2013) Abstract \| Provisional PDF \| Editor’s summary The integration of exposure assessment, basic toxicology and models to investigate effective interventions that mitigate or reverse adverse effects of environmental exposures may represent an effective portfolio to improve health by minimizing exposure and producing specific therapeutics.
		Research article Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice Hatem Sallam, Ibrahim El-Serafi, Laurent Meijer, Moustapha Hassan BMC Pharmacology and Toxicology 2013, 14:50 (30 September 2013) Abstract \| Full text \| PDF
		Research article The current status and trend of clinical pharmacology in developing countries Andrew Walubo BMC Pharmacology and Toxicology 2013, 14:49 (28 September 2013) Abstract \| Provisional PDF \| PubMed
		Research article The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells R Preston Mason, Robert F Jacob, J Jose Corbalan, Damian Szczesny, Kinga Matysiak, Tadeusz Malinski BMC Pharmacology and Toxicology 2013, 14:48 (28 September 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The ability of nebivolol to stimulate nitric oxide release appears to be independent of its selective beta1-adrenoceptor blockade properties and dependent on stimulation of beta3-adrenoceptors and ATP-mediated stimulation of P2Y-purinergic receptors in human endothelial cells.
		Research article Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells Maria Luisa Dupuis, Alessandro Ascione, Lucia Palmisano, Stefano Vella, Maurizio Cianfriglia BMC Pharmacology and Toxicology 2013, 14:47 (20 September 2013) Abstract \| Provisional PDF \| PubMed
		Research article Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning Ahmed E Enayetallah, Dinesh Puppala, Daniel Ziemek, James E Fischer, Sheila Kantesaria, Mathew T Pletcher BMC Pharmacology and Toxicology 2013, 14:46 (6 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Case report Tissue concentration of paraquat on day 32 after intoxication and failed bridge to transplantation by extracorporeal membrane oxygenation therapy Anna Bertram, Sascha Sebastian Haenel, Johannes Hadem, Marius M Hoeper, Jens Gottlieb, Gregor Warnecke, Stanislav Kaschinski, Carsten Hafer, W Nikolaus Kühn-Velten, Detlef Günther, Jan T Kielstein BMC Pharmacology and Toxicology 2013, 14:45 (6 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Active post-marketing surveillance of the intralesional administration of human recombinant epidermal growth factor in diabetic foot ulcers Isis B Yera-Alos, Liuba Alonso-Carbonell, Carmen M Valenzuela-Silva, Angela D Tuero-Iglesias, Martha Moreira-Martínez, Ivonne Marrero-Rodríguez, Ernesto López-Mola, Pedro A López-Saura BMC Pharmacology and Toxicology 2013, 14:44 (3 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Tocopheryl acetate 20% spray for elimination of head louse infestation: a randomised controlled trial comparing with 1% permethrin creme rinse Ian F Burgess, Nazma A Burgess, Elizabeth R Brunton BMC Pharmacology and Toxicology 2013, 14:43 (3 September 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial An interview with David H Farb, Section Editor for Basic Pharmacology David H Farb BMC Pharmacology and Toxicology 2013, 14:42 (30 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Section Editor David Farb provides his insights on recent developments in the field of pharmacology and discusses his future aspirations for BMC Pharmacology and Toxicology.
		Case report Memory loss during lenalidomide treatment: a report on two cases Adeline Rollin-Sillaire, Xavier Delbeuck, Marianne Pollet, Marie-Anne Mackowiak, Pierre Lenfant, Marie-Pierre Noel, Thierry Facon, Xavier Leleu, Florence Pasquier, Emilie Le Rhun BMC Pharmacology and Toxicology 2013, 14:41 (12 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes Saik Urien, Christophe Bardin, Brigitte Bader-Meunier, Richard Mouy, Sandrine Compeyrot-Lacassagne, Franz Foissac, Benoît Florkin, Carine Wouters, Bénédicte Neven, Jean-Marc Treluyer, Pierre Quartier BMC Pharmacology and Toxicology 2013, 14:40 (5 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article The association between prescription change frequency, chronic disease score and hospital admissions: a case control study Carolien GM Sino, Rutger Stuffken, Eibert R Heerdink, Marieke J Schuurmans, Patrick C Souverein, Toine (A) CG Egberts BMC Pharmacology and Toxicology 2013, 14:39 (1 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Olanzapine in pregnancy and breastfeeding: a review of data from global safety surveillance Elizabeth Brunner, Deborah M Falk, Meghan Jones, Debashish K Dey, Chetan Shatapathy BMC Pharmacology and Toxicology 2013, 14:38 (1 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity Shamol Saha, Yinghui Hu, Stella C Martin, Sabita Bandyopadhyay, Shelley J Russek, David H Farb BMC Pharmacology and Toxicology 2013, 14:37 (23 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Polycomblike protein PHF1b stimulates GABRB1 promoter activity in primary cultured neurons and chronic GABA exposure regulates PHF1 binding to endogenous Gabrb1 indicating its role as a molecular transducer of GABA-mediated neurotransmission.
		Research article Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2 Shu Liu, David Hsieh, Yi-Lin Yang, Zhidong Xu, Csaba Peto, David M Jablons, Liang You BMC Pharmacology and Toxicology 2013, 14:36 (11 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Cell-free, in vitro and molecular docking studies indicate that the phytoestrogen coumestrol is a novel ATP competitive and cell permeable Casein kinase 2 (CK2) inhibitor with a submicromolar IC₅₀.
		Research article Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine Therese Bredholt, Elisabeth Ersvær, Bjarte Erikstein, André Sulen, Håkon Reikvam, Hans Aarstad, Anne Johannessen, Olav Vintermyr, Øystein Bruserud, Bjørn Gjertsen BMC Pharmacology and Toxicology 2013, 14:35 (11 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Quantitation of small intestinal permeability during normal human drug absorption David G Levitt BMC Pharmacology and Toxicology 2013, 14:34 (24 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Effects of packaging and storage conditions on the quality of amoxicillin-clavulanic acid – an analysis of Cambodian samples Mohiuddin Khan, Kirara Hatanaka, Tey Sovannarith, Nam Nivanna, Lidia Cecilia Cadena Casas, Naoko Yoshida, Hirohito Tsuboi, Tsuyoshi Tanimoto, Kazuko Kimura BMC Pharmacology and Toxicology 2013, 14:33 (18 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells Monica Pallis, Francis Burrows, Abigail Whittall, Nicholas Boddy, Claire Seedhouse, Nigel Russell BMC Pharmacology and Toxicology 2013, 14:32 (15 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl–like molecules binding Adriana Isvoran, Dana Craciun, Virginie Martiny, Olivier Sperandio, Maria A Miteva BMC Pharmacology and Toxicology 2013, 14:31 (14 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Computational analysis of proteins that interact with alpha-helical peptides suggests no sequence requirements for binding and highlights the presence of hydrophobic regions at the protein surface and non-uniform hydrophobicity across binding pockets.
		Research article Adverse drug reactions reported by consumers for nervous system medications in Europe 2007 to 2011 Lise Aagaard, Ebba Hansen BMC Pharmacology and Toxicology 2013, 14:30 (13 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Database Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria Prabakaran Pitchandi, Waheeta Hopper, Rathankar Rao BMC Pharmacology and Toxicology 2013, 14:29 (22 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats Nagesh Gowda, Anilkumar Dandu, Jaideep Singh, Sanghamitra Biswas, Vijaya Raghav, Mudigere N Lakshmi, Pavagada C Shilpa, Venkategowda Sunil, Ashokkumar Reddy, Manojkumar Sadasivuni, Kumaraswamy Aparna, Mahesh Verma, Yoganand Moolemath, Mammen O Anup, Marikunte V Venkataranganna, Baggavalli P Somesh, Madanahalli R Jagannath BMC Pharmacology and Toxicology 2013, 14:28 (21 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Rats treated with CNX-011-67 demonstrate improved glucose mediated insulin secretion and insulin gene transcription, enhanced glucose oxidation in the form of increased islet ATP content and overall improvement in beta cell health.
		Research article First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus Anita Kapur, Robin O’Connor-Semmes, Elizabeth K Hussey, Robert L Dobbins, Wenli Tao, Marcus Hompesch, Glenn A Smith, Joseph W Polli, Charles D James Jr, Imao Mikoshiba, Derek J Nunez BMC Pharmacology and Toxicology 2013, 14:26 (13 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed

	All
		Debate Translational toxicology: a developmental focus for integrated research strategies Claude Hughes, Michael Waters, David Allen, Iyabo Obasanjo BMC Pharmacology and Toxicology 2013, 14:51 (30 September 2013) Abstract \| Provisional PDF \| Editor’s summary The integration of exposure assessment, basic toxicology and models to investigate effective interventions that mitigate or reverse adverse effects of environmental exposures may represent an effective portfolio to improve health by minimizing exposure and producing specific therapeutics.
		Research article Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice Hatem Sallam, Ibrahim El-Serafi, Laurent Meijer, Moustapha Hassan BMC Pharmacology and Toxicology 2013, 14:50 (30 September 2013) Abstract \| Full text \| PDF
		Research article The current status and trend of clinical pharmacology in developing countries Andrew Walubo BMC Pharmacology and Toxicology 2013, 14:49 (28 September 2013) Abstract \| Provisional PDF \| PubMed
		Research article The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells R Preston Mason, Robert F Jacob, J Jose Corbalan, Damian Szczesny, Kinga Matysiak, Tadeusz Malinski BMC Pharmacology and Toxicology 2013, 14:48 (28 September 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The ability of nebivolol to stimulate nitric oxide release appears to be independent of its selective beta1-adrenoceptor blockade properties and dependent on stimulation of beta3-adrenoceptors and ATP-mediated stimulation of P2Y-purinergic receptors in human endothelial cells.
		Research article Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells Maria Luisa Dupuis, Alessandro Ascione, Lucia Palmisano, Stefano Vella, Maurizio Cianfriglia BMC Pharmacology and Toxicology 2013, 14:47 (20 September 2013) Abstract \| Provisional PDF \| PubMed
		Research article Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning Ahmed E Enayetallah, Dinesh Puppala, Daniel Ziemek, James E Fischer, Sheila Kantesaria, Mathew T Pletcher BMC Pharmacology and Toxicology 2013, 14:46 (6 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Case report Tissue concentration of paraquat on day 32 after intoxication and failed bridge to transplantation by extracorporeal membrane oxygenation therapy Anna Bertram, Sascha Sebastian Haenel, Johannes Hadem, Marius M Hoeper, Jens Gottlieb, Gregor Warnecke, Stanislav Kaschinski, Carsten Hafer, W Nikolaus Kühn-Velten, Detlef Günther, Jan T Kielstein BMC Pharmacology and Toxicology 2013, 14:45 (6 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Active post-marketing surveillance of the intralesional administration of human recombinant epidermal growth factor in diabetic foot ulcers Isis B Yera-Alos, Liuba Alonso-Carbonell, Carmen M Valenzuela-Silva, Angela D Tuero-Iglesias, Martha Moreira-Martínez, Ivonne Marrero-Rodríguez, Ernesto López-Mola, Pedro A López-Saura BMC Pharmacology and Toxicology 2013, 14:44 (3 September 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Tocopheryl acetate 20% spray for elimination of head louse infestation: a randomised controlled trial comparing with 1% permethrin creme rinse Ian F Burgess, Nazma A Burgess, Elizabeth R Brunton BMC Pharmacology and Toxicology 2013, 14:43 (3 September 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial An interview with David H Farb, Section Editor for Basic Pharmacology David H Farb BMC Pharmacology and Toxicology 2013, 14:42 (30 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Section Editor David Farb provides his insights on recent developments in the field of pharmacology and discusses his future aspirations for BMC Pharmacology and Toxicology.
		Case report Memory loss during lenalidomide treatment: a report on two cases Adeline Rollin-Sillaire, Xavier Delbeuck, Marianne Pollet, Marie-Anne Mackowiak, Pierre Lenfant, Marie-Pierre Noel, Thierry Facon, Xavier Leleu, Florence Pasquier, Emilie Le Rhun BMC Pharmacology and Toxicology 2013, 14:41 (12 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes Saik Urien, Christophe Bardin, Brigitte Bader-Meunier, Richard Mouy, Sandrine Compeyrot-Lacassagne, Franz Foissac, Benoît Florkin, Carine Wouters, Bénédicte Neven, Jean-Marc Treluyer, Pierre Quartier BMC Pharmacology and Toxicology 2013, 14:40 (5 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article The association between prescription change frequency, chronic disease score and hospital admissions: a case control study Carolien GM Sino, Rutger Stuffken, Eibert R Heerdink, Marieke J Schuurmans, Patrick C Souverein, Toine (A) CG Egberts BMC Pharmacology and Toxicology 2013, 14:39 (1 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Olanzapine in pregnancy and breastfeeding: a review of data from global safety surveillance Elizabeth Brunner, Deborah M Falk, Meghan Jones, Debashish K Dey, Chetan Shatapathy BMC Pharmacology and Toxicology 2013, 14:38 (1 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity Shamol Saha, Yinghui Hu, Stella C Martin, Sabita Bandyopadhyay, Shelley J Russek, David H Farb BMC Pharmacology and Toxicology 2013, 14:37 (23 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Polycomblike protein PHF1b stimulates GABRB1 promoter activity in primary cultured neurons and chronic GABA exposure regulates PHF1 binding to endogenous Gabrb1 indicating its role as a molecular transducer of GABA-mediated neurotransmission.
		Research article Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2 Shu Liu, David Hsieh, Yi-Lin Yang, Zhidong Xu, Csaba Peto, David M Jablons, Liang You BMC Pharmacology and Toxicology 2013, 14:36 (11 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Cell-free, in vitro and molecular docking studies indicate that the phytoestrogen coumestrol is a novel ATP competitive and cell permeable Casein kinase 2 (CK2) inhibitor with a submicromolar IC₅₀.
		Research article Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine Therese Bredholt, Elisabeth Ersvær, Bjarte Erikstein, André Sulen, Håkon Reikvam, Hans Aarstad, Anne Johannessen, Olav Vintermyr, Øystein Bruserud, Bjørn Gjertsen BMC Pharmacology and Toxicology 2013, 14:35 (11 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Quantitation of small intestinal permeability during normal human drug absorption David G Levitt BMC Pharmacology and Toxicology 2013, 14:34 (24 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Effects of packaging and storage conditions on the quality of amoxicillin-clavulanic acid – an analysis of Cambodian samples Mohiuddin Khan, Kirara Hatanaka, Tey Sovannarith, Nam Nivanna, Lidia Cecilia Cadena Casas, Naoko Yoshida, Hirohito Tsuboi, Tsuyoshi Tanimoto, Kazuko Kimura BMC Pharmacology and Toxicology 2013, 14:33 (18 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells Monica Pallis, Francis Burrows, Abigail Whittall, Nicholas Boddy, Claire Seedhouse, Nigel Russell BMC Pharmacology and Toxicology 2013, 14:32 (15 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl–like molecules binding Adriana Isvoran, Dana Craciun, Virginie Martiny, Olivier Sperandio, Maria A Miteva BMC Pharmacology and Toxicology 2013, 14:31 (14 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Computational analysis of proteins that interact with alpha-helical peptides suggests no sequence requirements for binding and highlights the presence of hydrophobic regions at the protein surface and non-uniform hydrophobicity across binding pockets.
		Research article Adverse drug reactions reported by consumers for nervous system medications in Europe 2007 to 2011 Lise Aagaard, Ebba Hansen BMC Pharmacology and Toxicology 2013, 14:30 (13 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Database Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria Prabakaran Pitchandi, Waheeta Hopper, Rathankar Rao BMC Pharmacology and Toxicology 2013, 14:29 (22 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats Nagesh Gowda, Anilkumar Dandu, Jaideep Singh, Sanghamitra Biswas, Vijaya Raghav, Mudigere N Lakshmi, Pavagada C Shilpa, Venkategowda Sunil, Ashokkumar Reddy, Manojkumar Sadasivuni, Kumaraswamy Aparna, Mahesh Verma, Yoganand Moolemath, Mammen O Anup, Marikunte V Venkataranganna, Baggavalli P Somesh, Madanahalli R Jagannath BMC Pharmacology and Toxicology 2013, 14:28 (21 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Rats treated with CNX-011-67 demonstrate improved glucose mediated insulin secretion and insulin gene transcription, enhanced glucose oxidation in the form of increased islet ATP content and overall improvement in beta cell health.
		Research article First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus Anita Kapur, Robin O’Connor-Semmes, Elizabeth K Hussey, Robert L Dobbins, Wenli Tao, Marcus Hompesch, Glenn A Smith, Joseph W Polli, Charles D James Jr, Imao Mikoshiba, Derek J Nunez BMC Pharmacology and Toxicology 2013, 14:26 (13 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed