BMC Pharmacology and Toxicology

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		Research article First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus Anita Kapur, Robin O¿Connor-Semmes, Elizabeth K Hussey, Robert L Dobbins, Wenli Tao, Marcus Hompesch, Glenn A Smith, Joseph W Polli, Charles D James Jr, Imao Mikoshiba, Derek J Nunez BMC Pharmacology and Toxicology 2013, 14:26 (13 May 2013) Abstract \| Provisional PDF \| PubMed
		Case report Rifampicin-warfarin interaction leading to macroscopic hematuria: a case report and review of the literature Maria AP Martins, Adriano MM Reis, Mariana F Sales, Vandack Nobre, Daniel D Ribeiro, Manoel OC Rocha, Antônio LP Ribeiro BMC Pharmacology and Toxicology 2013, 14:27 (4 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus Elizabeth K Hussey, Anita Kapur, Robin O¿Connor-Semmes, Wenli Tao, Bryan Rafferty, Joseph W Polli, Charles D James, Robert L Dobbins BMC Pharmacology and Toxicology 2013, 14:25 (30 April 2013) Abstract \| Provisional PDF \| PubMed
		Reviewer acknowledgement Annual acknowledgement of manuscript reviewers Christopher Morrey BMC Pharmacology and Toxicology 2013, 14:21 (29 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Pharmaceutical quality of seven generic Levodopa/Benserazide products compared with original Madopar® / Prolopa® Urs E Gasser, Anton Fischer, Jan P Timmermans, Isabelle Arnet BMC Pharmacology and Toxicology 2013, 14:24 (23 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Review Role of astrocytes in manganese mediated neurotoxicity Marta Sidoryk-Wegrzynowicz, Michael Aschner BMC Pharmacology and Toxicology 2013, 14:23 (18 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis Farshad Kajbaf, Jean-Daniel Lalau BMC Pharmacology and Toxicology 2013, 14:22 (12 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Study protocol Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP) H K Ruben Thanacoody, Alasdair Gray, James W Dear, Judy Coyle, Euan A Sandilands, David J Webb, Steff Lewis, Michael Eddleston, Simon HL Thomas, D Nicholas Bateman BMC Pharmacology and Toxicology 2013, 14:20 (4 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Case report Cotrimoxazole plasma levels, dialyzer clearance and total removal by extended dialysis in a patient with acute kidney injury: risk of under-dosing using current dosing recommendations Christian Clajus, W Nikolaus Kühn-Velten, Julius J Schmidt, Johan M Lorenzen, Daniel Pietsch, Gernot Beutel, Jan T Kielstein BMC Pharmacology and Toxicology 2013, 14:19 (3 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Anvirzel™ in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines Panagiotis Apostolou, Maria Toloudi, Marina Chatziioannou, Eleni Ioannou, Dennis R Knocke, Joe Nester, Dimitrios Komiotis, Ioannis Papasotiriou BMC Pharmacology and Toxicology 2013, 14:18 (25 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family Megan Morse, Haiyan Sun, Elizabeth Tran, Robert Levenson, Ye Fang BMC Pharmacology and Toxicology 2013, 14:17 (12 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A label-free integrative pharmacology on-target (iPOT) approach systematically surveys a library of opioid ligands against the opioid receptor family and effectively sorts them into distinct clusters based on their binding and functional selectivity.
		Research article Attitudes among healthcare professionals to the reporting of adverse drug reactions in Nepal Santosh KC, Pramote Tragulpiankit, Sarun Gorsanan, I Edwards BMC Pharmacology and Toxicology 2013, 14:16 (8 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin Ali S Alfazari, Bayan Al-Dabbagh, Saeeda Almarzooqi, Alia Albawardi, Abdul-Kader Souid BMC Pharmacology and Toxicology 2013, 14:15 (28 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study Anthony Cahn, Simon Hodgson, Robert Wilson, Jonathan Robertson, Joanna Watson, Misba Beerahee, Steve C Hughes, Graeme Young, Rebecca Graves, David Hall, Sjoerd van Marle, Roberto Solari BMC Pharmacology and Toxicology 2013, 14:14 (28 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice Kathryn A Ramsey, Alexander N Larcombe, Peter D Sly, Graeme R Zosky BMC Pharmacology and Toxicology 2013, 14:13 (18 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study Ronald G Hall, Kathleen A Hazlewood, Sara D Brouse, Christopher A Giuliano, Krystal K Haase, Chistopher R Frei, Nicolas A Forcade, Todd Bell, Roger J Bedimo, Carlos A Alvarez BMC Pharmacology and Toxicology 2013, 14:12 (13 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models Arkadiusz Gertych, Jin Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary 3D quantitative DNA methylation imaging enables the quantification of dose-dependent drug-induced spatial progression of DNA demethylation in cell nuclei, independent from interphase cell-cycle stages in conjunction with cytotoxicity.
		Research article Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units Maria Gustafsson, Stig Karlsson, Hugo Lövheim BMC Pharmacology and Toxicology 2013, 14:10 (8 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.
		Case report Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide Vincenzo Lariccia, Alessandra Moraca, Marco Marini, Annamaria Assunta Nasti, Ilaria Battistoni, Salvatore Amoroso, Gian Piero Perna BMC Pharmacology and Toxicology 2013, 14:8 (24 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate Mohamed A Ibrahim, Diana V Do, Yasir J Sepah, Syed M Shah, Elizabeth Van Anden, Gulnar Hafiz, J Kevin Donahue, Richard Rivers, Jai Balkissoon, James T Handa, Peter A Campochiaro, Quan Dong Nguyen BMC Pharmacology and Toxicology 2013, 14:7 (14 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231 Mariel Núñez, Vanina Medina, Graciela Cricco, Máximo Croci, Claudia Cocca, Elena Rivera, Rosa Bergoc, Gabriela Martín BMC Pharmacology and Toxicology 2013, 14:6 (11 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil Márcia Germana Alves de Araújo Lobo, Sandra Maria Botelho Pinheiro, José Gerley Díaz Castro, Valéria Gomes Momenté, Maria-Cristina S Pranchevicius BMC Pharmacology and Toxicology 2013, 14:5 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Allosteric transition: a comparison of two models Niels Bindslev BMC Pharmacology and Toxicology 2013, 14:4 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Hit identification of IKKβ natural product inhibitor Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma BMC Pharmacology and Toxicology 2013, 14:3 (7 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A benzoic acid derivative, identified by high-throughput virtual screening and molecular modeling, is capable of inhibiting IKKβ phosphorylation activity in vitro, and blocking IκBα protein degradation together with subsequent NF-κB activation in human cells.

	All
		Research article First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus Anita Kapur, Robin O¿Connor-Semmes, Elizabeth K Hussey, Robert L Dobbins, Wenli Tao, Marcus Hompesch, Glenn A Smith, Joseph W Polli, Charles D James Jr, Imao Mikoshiba, Derek J Nunez BMC Pharmacology and Toxicology 2013, 14:26 (13 May 2013) Abstract \| Provisional PDF \| PubMed
		Case report Rifampicin-warfarin interaction leading to macroscopic hematuria: a case report and review of the literature Maria AP Martins, Adriano MM Reis, Mariana F Sales, Vandack Nobre, Daniel D Ribeiro, Manoel OC Rocha, Antônio LP Ribeiro BMC Pharmacology and Toxicology 2013, 14:27 (4 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus Elizabeth K Hussey, Anita Kapur, Robin O¿Connor-Semmes, Wenli Tao, Bryan Rafferty, Joseph W Polli, Charles D James, Robert L Dobbins BMC Pharmacology and Toxicology 2013, 14:25 (30 April 2013) Abstract \| Provisional PDF \| PubMed
		Reviewer acknowledgement Annual acknowledgement of manuscript reviewers Christopher Morrey BMC Pharmacology and Toxicology 2013, 14:21 (29 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Pharmaceutical quality of seven generic Levodopa/Benserazide products compared with original Madopar® / Prolopa® Urs E Gasser, Anton Fischer, Jan P Timmermans, Isabelle Arnet BMC Pharmacology and Toxicology 2013, 14:24 (23 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Review Role of astrocytes in manganese mediated neurotoxicity Marta Sidoryk-Wegrzynowicz, Michael Aschner BMC Pharmacology and Toxicology 2013, 14:23 (18 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis Farshad Kajbaf, Jean-Daniel Lalau BMC Pharmacology and Toxicology 2013, 14:22 (12 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Study protocol Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP) H K Ruben Thanacoody, Alasdair Gray, James W Dear, Judy Coyle, Euan A Sandilands, David J Webb, Steff Lewis, Michael Eddleston, Simon HL Thomas, D Nicholas Bateman BMC Pharmacology and Toxicology 2013, 14:20 (4 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Case report Cotrimoxazole plasma levels, dialyzer clearance and total removal by extended dialysis in a patient with acute kidney injury: risk of under-dosing using current dosing recommendations Christian Clajus, W Nikolaus Kühn-Velten, Julius J Schmidt, Johan M Lorenzen, Daniel Pietsch, Gernot Beutel, Jan T Kielstein BMC Pharmacology and Toxicology 2013, 14:19 (3 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Anvirzel™ in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines Panagiotis Apostolou, Maria Toloudi, Marina Chatziioannou, Eleni Ioannou, Dennis R Knocke, Joe Nester, Dimitrios Komiotis, Ioannis Papasotiriou BMC Pharmacology and Toxicology 2013, 14:18 (25 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family Megan Morse, Haiyan Sun, Elizabeth Tran, Robert Levenson, Ye Fang BMC Pharmacology and Toxicology 2013, 14:17 (12 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A label-free integrative pharmacology on-target (iPOT) approach systematically surveys a library of opioid ligands against the opioid receptor family and effectively sorts them into distinct clusters based on their binding and functional selectivity.
		Research article Attitudes among healthcare professionals to the reporting of adverse drug reactions in Nepal Santosh KC, Pramote Tragulpiankit, Sarun Gorsanan, I Edwards BMC Pharmacology and Toxicology 2013, 14:16 (8 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin Ali S Alfazari, Bayan Al-Dabbagh, Saeeda Almarzooqi, Alia Albawardi, Abdul-Kader Souid BMC Pharmacology and Toxicology 2013, 14:15 (28 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study Anthony Cahn, Simon Hodgson, Robert Wilson, Jonathan Robertson, Joanna Watson, Misba Beerahee, Steve C Hughes, Graeme Young, Rebecca Graves, David Hall, Sjoerd van Marle, Roberto Solari BMC Pharmacology and Toxicology 2013, 14:14 (28 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice Kathryn A Ramsey, Alexander N Larcombe, Peter D Sly, Graeme R Zosky BMC Pharmacology and Toxicology 2013, 14:13 (18 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study Ronald G Hall, Kathleen A Hazlewood, Sara D Brouse, Christopher A Giuliano, Krystal K Haase, Chistopher R Frei, Nicolas A Forcade, Todd Bell, Roger J Bedimo, Carlos A Alvarez BMC Pharmacology and Toxicology 2013, 14:12 (13 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models Arkadiusz Gertych, Jin Oh, Kolja A Wawrowsky, Daniel J Weisenberger, Jian Tajbakhsh BMC Pharmacology and Toxicology 2013, 14:11 (11 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary 3D quantitative DNA methylation imaging enables the quantification of dose-dependent drug-induced spatial progression of DNA demethylation in cell nuclei, independent from interphase cell-cycle stages in conjunction with cytotoxicity.
		Research article Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units Maria Gustafsson, Stig Karlsson, Hugo Lövheim BMC Pharmacology and Toxicology 2013, 14:10 (8 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.
		Case report Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide Vincenzo Lariccia, Alessandra Moraca, Marco Marini, Annamaria Assunta Nasti, Ilaria Battistoni, Salvatore Amoroso, Gian Piero Perna BMC Pharmacology and Toxicology 2013, 14:8 (24 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate Mohamed A Ibrahim, Diana V Do, Yasir J Sepah, Syed M Shah, Elizabeth Van Anden, Gulnar Hafiz, J Kevin Donahue, Richard Rivers, Jai Balkissoon, James T Handa, Peter A Campochiaro, Quan Dong Nguyen BMC Pharmacology and Toxicology 2013, 14:7 (14 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231 Mariel Núñez, Vanina Medina, Graciela Cricco, Máximo Croci, Claudia Cocca, Elena Rivera, Rosa Bergoc, Gabriela Martín BMC Pharmacology and Toxicology 2013, 14:6 (11 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil Márcia Germana Alves de Araújo Lobo, Sandra Maria Botelho Pinheiro, José Gerley Díaz Castro, Valéria Gomes Momenté, Maria-Cristina S Pranchevicius BMC Pharmacology and Toxicology 2013, 14:5 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Allosteric transition: a comparison of two models Niels Bindslev BMC Pharmacology and Toxicology 2013, 14:4 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Hit identification of IKKβ natural product inhibitor Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma BMC Pharmacology and Toxicology 2013, 14:3 (7 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A benzoic acid derivative, identified by high-throughput virtual screening and molecular modeling, is capable of inhibiting IKKβ phosphorylation activity in vitro, and blocking IκBα protein degradation together with subsequent NF-κB activation in human cells.