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Volume 10 Supplement 1

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR)

Meeting abstracts

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR)

Vienna, Austria

25-27 November 2010

Edited by Andrea Laslop and Thomas Griesbacher

Additional Information | Conference website

Meeting abstract   Open Access

The trafficking of GPR55 is regulated by the G protein-coupled receptor-associated sorting protein 1

Julia Kargl, Nariman Balenga, Wolfgang Platzer, Lene Martini, Jennifer Whistler, Maria Waldhoer BMC Pharmacology 2010, 10(Suppl 1):A1 (16 November 2010)

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Meeting abstract   Open Access

Effect of rat common carotid artery occlusion on vascular action of adenosine

Miroslav Radenković, Radmila Stevanović, Marko Stojanović, Mirko Topalović, Milica Stojiljković BMC Pharmacology 2010, 10(Suppl 1):A2 (16 November 2010)

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Meeting abstract   Open Access

Resveratrol reduces myofibroblast arrhythmogenicity

Christian Rosker, Nicolò Salvarani, Stephan Rohr BMC Pharmacology 2010, 10(Suppl 1):A3 (16 November 2010)

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Meeting abstract   Open Access

A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids

Muhammad Asim, Gerhard Wolber, Mariana Spetea, Helmut Schmidhammer BMC Pharmacology 2010, 10(Suppl 1):A4 (16 November 2010)

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Meeting abstract   Open Access

Enhanced fear expression in a psychphathological mouse model of trait anxiety: pharmacological interventions

Markus Hauschild, Simone B Sartori, Mirjam Bunck, Stefano Gaburro, Rainer Landgraf, Nicolas Singewald BMC Pharmacology 2010, 10(Suppl 1):A5 (16 November 2010)

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Meeting abstract   Open Access

The interplay of excitatory and inhibitory coupling modes is crucial for the regulation of neuronal electrical activities by L-type calcium channels

Petra Geier, Michael Lagler, Stefan Boehm, Helmut Kubista BMC Pharmacology 2010, 10(Suppl 1):A6 (16 November 2010)

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Meeting abstract   Open Access

Cross-talk of PGD2 receptors: the DP receptor modulates signaling and trafficking of CRTH2

Miriam Sedej, Wolfgang Platzer, Ákos Heinemann, Maria Waldhoer BMC Pharmacology 2010, 10(Suppl 1):A7 (16 November 2010)

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Meeting abstract   Open Access

Signalling and function of the human G protein-coupled receptor 55

Nariman Balenga, Julia Kargl, Ralf Schröder, Ákos Heinemann, Evi Kostenis, Maria Waldhoer BMC Pharmacology 2010, 10(Suppl 1):A8 (16 November 2010)

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Meeting abstract   Open Access

Is thymoquinone an antioxidant?

Katrin Staniek, Lars Gille BMC Pharmacology 2010, 10(Suppl 1):A9 (16 November 2010)

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Meeting abstract   Open Access

Toxicity of ascaridole from Chenopodium ambrosioides in mammalian mitochondria

Lars Gille, Lianet Monzote, Werner Stamberg, Katrin Staniek BMC Pharmacology 2010, 10(Suppl 1):A10 (16 November 2010)

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Meeting abstract   Open Access

Concentrative ER export of the serotonin transporter relies exclusively on an interaction with Sec24C

Sonja Sucic, Ali El-Kasaby, Subhodeep Sarker, Harald H Sitte, Philippe Marin, Michael Freissmuth BMC Pharmacology 2010, 10(Suppl 1):A11 (16 November 2010)

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Meeting abstract   Open Access

Long-term regulation of ATP-binding cassette transporters on mRNA and protein level by simvastatin in human rhabdomyosarcoma and neuroblastoma cells

Bihter Atil, Martin Werner, Evelyn Sieczkowski, Peter Chiba, Martin Hohenegger BMC Pharmacology 2010, 10(Suppl 1):A12 (16 November 2010)

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Meeting abstract   Open Access

Interactions of peripheral and central μ opioid systems during emotional stress

Valentina Bashkatova, Helmut Prast, Alexei Umriukhin, Sergey Sudakov BMC Pharmacology 2010, 10(Suppl 1):A13 (16 November 2010)

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Meeting abstract   Open Access

Effects on cell proliferation and EPR spin trapping studies of Abnormal Savda Munziq and its chromatographic subfractions

Klaus Stolze, Adiljan Ablimit, Alois Strasser BMC Pharmacology 2010, 10(Suppl 1):A14 (16 November 2010)

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Meeting abstract   Open Access

Molecular engineering of the TRPC3 pore structure identifies Ca2+ permeation through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling

Michaela Lichtenegger, Hannes Schleifer, Thomas Stockner, Christoph Romanin, Michael Poteser, Klaus Groschner BMC Pharmacology 2010, 10(Suppl 1):A15 (16 November 2010)

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Meeting abstract   Open Access

Interaction of manganese with striatal dopamine turnover in human alpha-synuclein transgenic mice

Tamara M Peneder, Michael Berger, Petra Scholze, Georg Heinze, Johanna Bertl, Jan Bauer, Oleh Hornykiewicz, Eric K Richfield, Christian Pifl BMC Pharmacology 2010, 10(Suppl 1):A16 (16 November 2010)

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Meeting abstract   Open Access

A biological target for antiplatelet therapy: the prostaglandin E2 receptor EP4

Sonia Philipose, Martina Ofner, Ákos Heinemann, Rufina Schuligoi BMC Pharmacology 2010, 10(Suppl 1):A17 (16 November 2010)

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Meeting abstract   Open Access

The role of the carboxyl terminus in folding of the serotonin transporter

Ali El-Kasaby, Herwig Just, Harald Sitte, Oliver Kudlacek, Michael Freissmuth BMC Pharmacology 2010, 10(Suppl 1):A18 (16 November 2010)

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Meeting abstract   Open Access

Calmodulin kinase II regulates amphetamine-induced reverse transport in the dopamine transporter: implications for the importance of the dopamine transporter in Angelman syndrome

Thomas Steinkellner, Oliver Kudlacek, Michael Freissmuth, Ype Elgersma, Harald Sitte BMC Pharmacology 2010, 10(Suppl 1):A19 (16 November 2010)

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Meeting abstract   Open Access

α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation

Robert Trondl, Christian R Kowol, Vladimir B Arion, Michael A Jakupec, Bernhard K Keppler BMC Pharmacology 2010, 10(Suppl 1):A20 (16 November 2010)

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Meeting abstract   Open Access

The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter

Subhodeep Sarker, René Weissensteiner, Ilka Steiner, Harald H Sitte, Gerhard F Ecker, Michael Freissmuth, Sonja Sucic BMC Pharmacology 2010, 10(Suppl 1):A21 (16 November 2010)

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Meeting abstract   Open Access

4-Methylthioamphetamine (4-MTA) induces mitochondrial-dependent apoptosis in SH-SY5Y cells independently of dopamine and noradrenaline transporters

Therese Montgomery, Harald Sitte, Gethin McBean BMC Pharmacology 2010, 10(Suppl 1):A22 (16 November 2010)

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Meeting abstract   Open Access

A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel

René Cervenka, Péter Lukács, Touran Zarrabi, Xaver Koenig, Agnés Mike, Karlheinz Hilber, Hannes Todt BMC Pharmacology 2010, 10(Suppl 1):A23 (16 November 2010)

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Meeting abstract   Open Access

The permanently charged lidocaine analogue QX222 acts as a blocker from the intracellular side and as an inactivation modulator from the extracellular side in a mutant NaV1.4 channel

Péter Lukács, René Cervenka, Xaver Koenig, Agnés Mike, Touran Zarrabi, Karlheinz Hilber, Hannes Todt BMC Pharmacology 2010, 10(Suppl 1):A24 (16 November 2010)

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Meeting abstract   Open Access

Altered sodium channel function in dystrophin/utrophin-deficient cardiomyocytes

Xaver Koenig, Agnes Mike, Markus Mille, René Cervenka, Péter Lukács, Katrin Nagl, Xuan Dang, Hannes Todt, Reginald E Bittner, Karlheinz Hilber BMC Pharmacology 2010, 10(Suppl 1):A25 (16 November 2010)

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Meeting abstract   Open Access

The interactome of the A2A adenosine receptor in vitro and in vivo

Christian Bergmayr, Christian Nanoff, Oliver Kudlacek, Christian Gruber BMC Pharmacology 2010, 10(Suppl 1):A26 (16 November 2010)

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Meeting abstract   Open Access

Conformation of membrane-inserted P-glycoprotein

Thomas Stockner, Harald H Sitte, Peter Chiba BMC Pharmacology 2010, 10(Suppl 1):A27 (16 November 2010)

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Meeting abstract   Open Access

Selective serotonin reuptake inhibitor-induced cell death: in search of a mechanism

Christina Glöckel, Christoph Minichsdorfer, Gerhard F Ecker, Michael Freissmuth BMC Pharmacology 2010, 10(Suppl 1):A28 (16 November 2010)

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Meeting abstract   Open Access

The pulmonary microvascular endothelial barrier function is controlled by the PGE2-EP4 signaling axis

Viktória Kónya, Andreas Üllen, Eva M Sturm, Petra Luschnig, Wolfgang Sattler, Ákos Heinemann BMC Pharmacology 2010, 10(Suppl 1):A29 (16 November 2010)

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Meeting abstract   Open Access

Tracking the A2A adenosine receptor

Patrick Thurner, Simon Keuerleber, Ingrid Gsandtner, Michael Freissmuth, Jürgen Zezula BMC Pharmacology 2010, 10(Suppl 1):A30 (16 November 2010)

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Meeting abstract   Open Access

Luminescence resonance energy transfer-based intramolecular distance measurements in leucine transporter from Aquifex aeolicus

Azmat Sohail, Peggy Stolt-Bergner, Gerhard F Ecker, Michael Freissmuth, Harald Sitte, Walter Sandtner BMC Pharmacology 2010, 10(Suppl 1):A31 (16 November 2010)

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Meeting abstract   Open Access

Endogenous dynorphin in emotional control and stress response revisited

Christoph Schwarzer, Christian Lutsch, Eduard Schunk, Iris Kastenberger, Herbert Herzog BMC Pharmacology 2010, 10(Suppl 1):A32 (16 November 2010)

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Meeting abstract   Open Access

Neuropeptide Y in the basolateral amygdala modulates the acquisition of conditioned fear

Ramon O Tasan, Dilip Verma, Herbert Herzog, Günther Sperk BMC Pharmacology 2010, 10(Suppl 1):A33 (16 November 2010)

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Meeting abstract   Open Access

Fear learning triggers structural changes at GABAergic synapses in the basal amygdala

Yu Kasugai, Markus Hauschild, Werner Sieghart, Ryuichi Shigemoto, Nicolas Singewald, Francesco Ferraguti BMC Pharmacology 2010, 10(Suppl 1):A34 (16 November 2010)

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Meeting abstract   Open Access

Short-chain methotrexate polyglutamate MTXPG2 as outcome parameter in rheumatoid arthritis

Eva-Luise Hobl, Bernd Jilma, Ludwig Erlacher, Robert Mader BMC Pharmacology 2010, 10(Suppl 1):A35 (16 November 2010)

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Meeting abstract   Open Access

Teicoplanin pharmacokinetics during albumin dialysis

Stefan Weiler, Gerda Falkensammer, Christoph Seger, Michael Joannidis, Romuald Bellmann BMC Pharmacology 2010, 10(Suppl 1):A36 (16 November 2010)

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Meeting abstract   Open Access

Endotoxin-induced microparticle formation is subject to tolerance development in humans

Daniel Nguyen, Stefan Weisshaar, Michael Wolzt BMC Pharmacology 2010, 10(Suppl 1):A37 (16 November 2010)

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Meeting abstract   Open Access

Does VEGF polymorphism play a role in the treatment success with VEGF inhibitors in patients with CNV?

Agnes Boltz, Günther Weigert, Stefan Palkovits, Manuel Ruiß, Martin Weger, Yosuf El-Shabrawi, Gerhard Garhöfer, Jost Jonas, Leopold Schmetterer BMC Pharmacology 2010, 10(Suppl 1):A38 (16 November 2010)

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Meeting abstract   Open Access

Antimicrobial activity of antibiotics in urine under different physiological conditions

Angela Burian, Zeynep Erdogan, Mohammad Manafi, Markus Zeitlinger BMC Pharmacology 2010, 10(Suppl 1):A39 (16 November 2010)

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Meeting abstract   Open Access

The influence of lutein supplementation on macular pigment optical density in patients with dry AMD compared with healthy control subjects

Semira Kaya, Günther Weigert, Nikolaus Dragostinoff, René Werkmeister, Berthold Pemp, Stefan Sacu, Gerhard Garhöfer, Ursula Schmidt-Erfurth, Leopold Schmetterer BMC Pharmacology 2010, 10(Suppl 1):A40 (16 November 2010)

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Meeting abstract   Open Access

BEZ235 impairs gastric cancer growth by inhibition of PI3K/mTOR in vitro and in vivo

Thorsten Füreder, Thomas Wanek, Pamina Pflegerl, Agnes Jaeger-Lansky, Doris Hoeflmayer, Sabine Strommer, Claudia Kuntner, Markus Müller, Oliver Langer, Volker Wacheck BMC Pharmacology 2010, 10(Suppl 1):A41 (16 November 2010)

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Meeting abstract   Open Access

Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo

Johannes Werzowa, Stefan Koehrer, Sabine Strommer, Daniel Cejka, Thorsten Füreder, Volker Wacheck BMC Pharmacology 2010, 10(Suppl 1):A42 (16 November 2010)

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Meeting abstract   Open Access

Thrombus formation is not pH-dependent

Stefan Weisshaar, Ghazaleh Gouya, Michael Wolzt BMC Pharmacology 2010, 10(Suppl 1):A43 (16 November 2010)

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Meeting abstract   Open Access

Inhibition of tissue factor pathway inhibitor (TFPI) by ARC19499 improves clotting of hemophiliac blood

Monika E Gorczyca, Bernd Jilma, Christoph Male, Sylvia Reitter, James C Gilbert, Ingrid Pabinger BMC Pharmacology 2010, 10(Suppl 1):A44 (16 November 2010)

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Meeting abstract   Open Access

Tissue pharmacokinetics of individual macrolides support observed differences in development of bacterial resistance

Shaip Krasniqi, Peter Matzneller, Martina Kinzig, Sven Hüttner, Fritz Sörgel, Markus Müller, Markus Zeitlinger BMC Pharmacology 2010, 10(Suppl 1):A45 (16 November 2010)

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Meeting abstract   Open Access

Small-animal PET evaluation of [11C]MC113 as a PET tracer for P-glycoprotein

Severin Mairinger, Nicola A Colabufo, Thomas Wanek, Claudia Kuntner, Johann Stanek, Thomas Erker, Mariangela Cantore, Francesco Berardi, Roberto Perrone, Markus Müller, Oliver Langer BMC Pharmacology 2010, 10(Suppl 1):A46 (16 November 2010)

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Meeting abstract   Open Access

Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[11C]verapamil PET

Martin Bauer, Markus Zeitlinger, Peter Matzneller, Johann Stanek, Edith Lackner, Wolfgang Wadsak, Markus Müller, Oliver Langer BMC Pharmacology 2010, 10(Suppl 1):A47 (16 November 2010)

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Meeting abstract   Open Access

Heterogeneous penetration of cefpirome and moxifloxacin into abscesses after simultaneous administration in humans

Robert Sauermann, Thomas Feurstein, Rudolf Karch, Andreas Püspök, Herbert Langenberger, Walter Jäger, Michaela Böhmdorfer, Thomas Wild, Stefan Winkler, Maria C Kjellsson, Markus Zeitlinger BMC Pharmacology 2010, 10(Suppl 1):A48 (16 November 2010)

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