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1.
812 Accesses
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Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans
Hiroshi Tsuneki, Mitsuyo Ishizuka, Miki Terasawa, Jin-Bin Wu, Toshiyasu Sasaoka, Ikuko Kimura BMC Pharmacology 2004, 4:18 (26 August 2004)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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2.
715 Accesses
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Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors
John Cuppoletti, Anthony T Blikslager, Jayati Chakrabarti, Prashant K Nighot, Danuta H Malinowska BMC Pharmacology 2012, 12:3 (3 May 2012)
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3.
499 Accesses
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Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor
Aiying Wang, Charles Dorso, Lisa Kopcho, Gregory Locke, Robert Langish, Eric Harstad, Petia Shipkova, Jovita Marcinkeviciene, Lawrence Hamann, Mark S Kirby BMC Pharmacology 2012, 12:2 (4 April 2012)
Abstract | Provisional PDF
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4.
420 Accesses
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Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers
Peter Bramlage, Adrian Goldis BMC Pharmacology 2008, 8:18 (29 October 2008)
Abstract | Full text | PDF | PubMed
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Editor’s summary
The ibuprofen preparation Eudorlin extra demonstrates the same bioavailability and bioequivalence to Nurofen forte and Migranin at a dose of 400mg, but reaches a higher peak plasma concentration and peaks earlier.
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5.
402 Accesses
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Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
Marie-Laure Volvert, Sandrine Seyen, Marie Piette, Brigitte Evrard, Marjorie Gangolf, Jean-Christophe Plumier, Lucien Bettendorff BMC Pharmacology 2008, 8:10 (12 June 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central |
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Editor’s summary
Benfotiamine, a non-prescription thiamine precursor indicated for a variety of disorders, has poor lipid solubility and is predicted to have little effect in central nervous system thiamine deficiencies compared with other precursors, despite widespread claims regarding its efficacy.
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6.
380 Accesses
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Computational models for in-vitro anti-tubercular activity of molecules based on high-throughput chemical biology screening datasets
Vinita Periwal, Shireesha Kishtapuram, Open Source Drug Discovery Consortium, Vinod Scaria BMC Pharmacology 2012, 12:1 (31 March 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Computational methods based on Machine Learning tools and supervised classifiers generate accurate predictive models for virtual high-throughput screens of large libraries of anti-tubercular molecules, allowing prioritization of good candidates for drug discovery.
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7.
342 Accesses
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Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice
Hossein Hosseinzadeh, Hani M Younesi BMC Pharmacology 2002, 2:7 (15 March 2002)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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8.
318 Accesses
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5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved
Robert P Davis, Jill Pattison, Janice M Thompson, Ruslan Tiniakov, Karie E Scrogin, Stephanie W Watts BMC Pharmacology 2012, 12:4 (6 May 2012)
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9.
221 Accesses
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Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice
Adeline YL Lim, Ignacio Segarra, Srikumar Chakravarthi, Sufyan Akram, John P Judson BMC Pharmacology 2010, 10:14 (15 October 2010)
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10.
216 Accesses
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Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line
Stephanie K Bopp, Teresa Lettieri BMC Pharmacology 2008, 8:8 (30 May 2008)
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11.
215 Accesses
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LCZ696, an angiotensin receptor neprilysin inhibitor (ARNI): clinical development in heart failure and hypertension
Martin P Lefkowitz BMC Pharmacology 2011, 11(Suppl 1):O3 (1 August 2011)
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12.
207 Accesses
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Weight loss dynamics during combined fluoxetine and olanzapine treatment
Jennifer A Perrone, Janet M Chabla, Brian H Hallas, Judith M Horowitz, German Torres BMC Pharmacology 2004, 4:27 (21 October 2004)
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13.
194 Accesses
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Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport
Huiling Liu, Jerry M Farley BMC Pharmacology 2005, 5:8 (24 March 2005)
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14.
193 Accesses
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Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells
Elizabeth Alli, Vandana B Sharma, Anne-Renee Hartman, Patrick S Lin, Lisa McPherson, James M Ford BMC Pharmacology 2011, 11:7 (19 July 2011)
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15.
181 Accesses
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Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney
Naveen Tirkey, Sangeeta Pilkhwal, Anurag Kuhad, Kanwaljit Chopra BMC Pharmacology 2005, 5:2 (31 January 2005)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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16.
179 Accesses
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Effect of dietary palm olein oil on oxidative stress associated with ischemic-reperfusion injury in isolated rat heart
Deepak Narang, Subeena Sood, Mathew Thomas, Amit Dinda, Subir Maulik BMC Pharmacology 2004, 4:29 (9 November 2004)
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17.
167 Accesses
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An evaluation of R2 as an inadequate measure for nonlinear models in pharmacological and biochemical research: a Monte Carlo approach
Andrej-Nikolai Spiess, Natalie Neumeyer BMC Pharmacology 2010, 10:6 (7 June 2010)
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18.
167 Accesses
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6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant
Arkene SA Levy, Oswald Simon, Janet Shelly, Michael Gardener BMC Pharmacology 2006, 6:12 (1 October 2006)
Abstract | Full text | PDF | PubMed
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Editor’s summary
One of the major active components in ginger, 6-shogaol, reduced knee inflammation and cartilage damage in a rat model of arthritis and was associated with decreased leukocyte infiltration and expression of vascular cell adhesion molecule-1.
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19.
162 Accesses
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Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study
Idrian García-García, Carlos A González-Delgado, Carmen M Valenzuela-Silva, Alina Díaz-Machado, Marisol Cruz-Díaz, Hugo Nodarse-Cuní, Orlando Pérez-Pérez, Cimara H Bermúdez-Badell, Joel Ferrero-Bibilonia, Rolando Páez-Meireles, Iraldo Bello-Rivero, Fidel R Castro-Odio, Pedro A López-Saura, for the FarmaPEG Study Group BMC Pharmacology 2010, 10:15 (23 November 2010)
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20.
162 Accesses
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Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro
W Dimpfel, JA Hoffmann BMC Pharmacology 2011, 11:2 (21 February 2011)
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Editor’s summary
The new Parkinson`s disease drug rasagiline and its metabolite aminoindan, affect the glutamate receptor mediated signaling pathway and display dose-dependent neuroprotective activity in the rat hippocampus.
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21.
154 Accesses
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A web server for predicting inhibitors against bacterial target GlmU protein
Deepak Singla, Meenakshi Anurag, Debasis Dash, Gajendra PS Raghava BMC Pharmacology 2011, 11:5 (6 July 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
A Quantitative Structure Activity Relationship (QSAR) model based on docking energy descriptors predicts potential inhibitors of the Mycobacterium tuberculosis drug target GlmU, that could be used in the development of drugs against tuberculosis.
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22.
153 Accesses
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Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors
Jacob D Durrant, J Andrew McCammon BMC Pharmacology 2011, 11:9 (30 August 2011)
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23.
144 Accesses
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Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats
Anthony Josephine, Kalaiselvam Nithya, Ganapathy Amudha, Coothan Veena, Sreenivasan P Preetha, Palaninathan Varalakshmi BMC Pharmacology 2008, 8:4 (20 February 2008)
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24.
142 Accesses
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Amphetamine Dependence and Co-Morbid Alcohol Abuse: Associations to Brain Cortical Thickness
Glenn Lawyer, Petr S Bjerkan, Anders Hammarberg, Nitya Jayaram-Lindström, Johan Franck, Ingrid Agartz BMC Pharmacology 2010, 10:5 (20 May 2010)
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25.
141 Accesses
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The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen
Jessica Stahl, Mareike Wohlert, Manfred Kietzmann BMC Pharmacology 2011, 11:12 (14 December 2011)
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