BMC Pharmacology | Vol 11

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Volume 11 (2011) - May 2011

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Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo

Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hiroshi Nanjo, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata BMC Pharmacology 2011, 11:4 (28 May 2011)

Abstract | Full text | PDF | PubMed | Editor’s summary

Synthetic analogs of natural curcumin, found in the popular Indian spice turmeric, overcome the compound's low bioavailability and display enhanced chemotherapeutic potential both in vitro and in a mouse model of colorectal carcinogenesis.